New understanding of Angelica sinensis polysaccharide improving fatty liver: The dual inhibition of lipid synthesis and CD36-mediated lipid uptake and the regulation of alcohol metabolism
Int J Biol Macromol. 2022 Mar 28:S0141-8130(22)00618-3. doi: 10.1016/j.ijbiomac.2022.03.148. Online ahead of print.ABSTRACTAngelica sinensis polysaccharide (ASP) has presented increasingly recognized lipid regulation and antioxidant abilities. However, there is little direct evidence to explain why ASP possesses the observed lipid-lowering and anti-oxidation effects. In vivo and in vitro models of alcoholic fatty liver disease (AFLD) were established to examine the direct effect of ASP on hepatic fat accumulation. Our results showed that the lipid-lowering effect of ASP might result from the dual inhibition of lipid synthe...
Source: International Journal of Biological Macromolecules - March 31, 2022 Category: Biochemistry Authors: Zihao He Tingting Guo Zheng Cui Jingya Xu Zhijing Wu Xiawen Yang Huiping Hu Hao Mei Jing Zhou Yu Zhang Kaiping Wang Source Type: research
New understanding of Angelica sinensis polysaccharide improving fatty liver: The dual inhibition of lipid synthesis and CD36-mediated lipid uptake and the regulation of alcohol metabolism
Int J Biol Macromol. 2022 Mar 28:S0141-8130(22)00618-3. doi: 10.1016/j.ijbiomac.2022.03.148. Online ahead of print.ABSTRACTAngelica sinensis polysaccharide (ASP) has presented increasingly recognized lipid regulation and antioxidant abilities. However, there is little direct evidence to explain why ASP possesses the observed lipid-lowering and anti-oxidation effects. In vivo and in vitro models of alcoholic fatty liver disease (AFLD) were established to examine the direct effect of ASP on hepatic fat accumulation. Our results showed that the lipid-lowering effect of ASP might result from the dual inhibition of lipid synthe...
Source: International Journal of Biological Macromolecules - March 31, 2022 Category: Biochemistry Authors: Zihao He Tingting Guo Zheng Cui Jingya Xu Zhijing Wu Xiawen Yang Huiping Hu Hao Mei Jing Zhou Yu Zhang Kaiping Wang Source Type: research
Retraction notice to "Angelica sinensis polysaccharide protects rat cardiomyocytes H9c2 from hypoxia-induced injury by down-regulation of microRNA-22" [Biomed. Pharmacother. 106 (2018) 225-231]
Biomed Pharmacother. 2022 Mar 24:112860. doi: 10.1016/j.biopha.2022.112860. Online ahead of print.NO ABSTRACTPMID:35341640 | DOI:10.1016/j.biopha.2022.112860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2022 Category: Drugs & Pharmacology Authors: Hui Pan Linlin Zhu Source Type: research
Retraction notice to "Angelica sinensis polysaccharide protects rat cardiomyocytes H9c2 from hypoxia-induced injury by down-regulation of microRNA-22" [Biomed. Pharmacother. 106 (2018) 225-231]
Biomed Pharmacother. 2022 Mar 24:112860. doi: 10.1016/j.biopha.2022.112860. Online ahead of print.NO ABSTRACTPMID:35341640 | DOI:10.1016/j.biopha.2022.112860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2022 Category: Drugs & Pharmacology Authors: Hui Pan Linlin Zhu Source Type: research
Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota
In this study, the collagen-induced rats were administrated with Angelica sinensis polysaccharide (ASP) at 200 mg/kg (L), 400 mg/kg (M), or 800 mg/kg (H). Results showed that ASP could reduce joint swelling and significantly inhibit anti-CII-antibodies and pro-inflammatory factors in RA, H group showed the best treatment among them. Further analysis using 16S rDNA sequencing suggested that ASP could shape the gut microbiota composition. Several key bacteria, including norank_f__norank_o__Clostridia_UCG-014, Lactobacillus, norank_f__Oscillospiraceae, and norank_f__Desulfovibrionaceae, were found to be related to the develop...
Source: International Journal of Biological Macromolecules - March 23, 2022 Category: Biochemistry Authors: Qing Hu Changyu Wu Juntong Yu Jianming Luo Xichun Peng Source Type: research
Polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide promote dendritic cells activation and associated molecular mechanisms
Int J Biol Macromol. 2022 Mar 11:S0141-8130(22)00498-6. doi: 10.1016/j.ijbiomac.2022.03.038. Online ahead of print.ABSTRACTCationic PLGA nanoparticles-based delivery systems have been extensively employed as nanocarriers for drugs and antigens in recent years. Herein, we investigated the effects of polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide (ASP) system (ASP-PLGA-PEI) on dendritic cells (DCs) activation and maturation, and further explore the changes of transcriptome and underlying mechanism of DCs activation based on RNA-seq. Our results demonstrated that ASP-PLGA-PEI obviously ...
Source: International Journal of Biological Macromolecules - March 15, 2022 Category: Biochemistry Authors: Pengfei Gu Gaofeng Cai Yang Yang Yuanliang Hu Jiaguo Liu Deyun Wang Source Type: research
Polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide promote dendritic cells activation and associated molecular mechanisms
Int J Biol Macromol. 2022 Mar 11:S0141-8130(22)00498-6. doi: 10.1016/j.ijbiomac.2022.03.038. Online ahead of print.ABSTRACTCationic PLGA nanoparticles-based delivery systems have been extensively employed as nanocarriers for drugs and antigens in recent years. Herein, we investigated the effects of polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide (ASP) system (ASP-PLGA-PEI) on dendritic cells (DCs) activation and maturation, and further explore the changes of transcriptome and underlying mechanism of DCs activation based on RNA-seq. Our results demonstrated that ASP-PLGA-PEI obviously ...
Source: International Journal of Biological Macromolecules - March 15, 2022 Category: Biochemistry Authors: Pengfei Gu Gaofeng Cai Yang Yang Yuanliang Hu Jiaguo Liu Deyun Wang Source Type: research
Polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide promote dendritic cells activation and associated molecular mechanisms
Int J Biol Macromol. 2022 Mar 12;207:559-569. doi: 10.1016/j.ijbiomac.2022.03.038. Online ahead of print.ABSTRACTCationic PLGA nanoparticles-based delivery systems have been extensively employed as nanocarriers for drugs and antigens in recent years. Herein, we investigated the effects of polyethylenimine-coated PLGA nanoparticles containing Angelica sinensis polysaccharide (ASP) system (ASP-PLGA-PEI) on dendritic cells (DCs) activation and maturation, and further explored the changes of transcriptome and underlying mechanism of DCs activation based on RNA-seq. Our results demonstrated that ASP-PLGA-PEI obviously promoted ...
Source: International Journal of Biological Macromolecules - March 15, 2022 Category: Biochemistry Authors: Pengfei Gu Gaofeng Cai Yang Yang Yuanliang Hu Jiaguo Liu Deyun Wang Source Type: research
Optimal Formula of Angelica sinensis Ameliorates Memory Deficits in β-amyloid Protein-induced Alzheimer’s Disease Rat Model
ConclusionThese experimental findings illustrate that AOF prevents the decrease in cognitive function and A β deposits in Aβ25 –35-treated rats via modulating neuroinflammation and oxidative stress, thus highlighting a potential therapeutic avenue to promote the co-administration of formulas that act on different nodes to maximize beneficial effects and minimize negative side effects. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - February 5, 2022 Category: Research Source Type: research
Comparison of Herbal Medicines Used for Women ’s Menstruation Diseases in Different Areas of the World
Conclusion: Women’s menstruation health is directly related to their health condition. Traditional medicines of most ethnic groups have contributed to women’s health care and treatment of gynecological diseases. Practitioners in this field have gained elaborate experience in treatments and medication, and assembled a large number of effective drugs and prescriptions. These experiences have also been inherited and developed by modern clinical application and scientific research. However, the basic research on these drugs is not sufficient, the knowledge of drug use has not been fully popularized, the advantages of drugs...
Source: Frontiers in Pharmacology - February 4, 2022 Category: Drugs & Pharmacology Source Type: research
Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates
Biochem Biophys Res Commun. 2022 Jan 13;594:8-14. doi: 10.1016/j.bbrc.2022.01.037. Online ahead of print.ABSTRACTLignin is a highly complex phenolic polymer which is essential for plants, but also makes it difficult for industrial processing. Engineering lignin by introducing relatively labile linkages into the lignin backbone can render it more amenable to chemical depolymerization. It has been reported that introducing a feruloyl-coenzyme A monolignol transferase from Angelica sinensis (AsFMT) into poplar could incorporate monolignol ferulate conjugates (ML-FAs) into lignin polymers, suggesting a promising way to manipul...
Source: Biochemical and Biophysical Research communications - January 23, 2022 Category: Biochemistry Authors: Xi Liu Shuliu Dai Yu Zhou Jinyue Liu Dong Li Jun Zhang Yushan Zhu Qiao Zhao Yue Feng Yi Zhang Source Type: research
Ethnopharmacological Survey of Traditional Chinese Medicine Pharmacy Prescriptions for Dysmenorrhea
This study provides a record of valuable knowledge on TCM pharmacy prescriptions for dysmenorrhea. The rich medicinal knowledge of TCM pharmacies in Taiwan is worthy of further exploration, and the results of this study can serve as a basis for future pharmacological research and the development of naturally derived medications for dysmenorrhea. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 21, 2021 Category: Drugs & Pharmacology Source Type: research
A Traditional Chinese Medicine Plant Extract Prevents Alcohol-Induced Osteopenia
In this study, Balb/c male mice were orally administrated alcohol (3.2 g/kg/day) with/without TCM herbal extracts (0.125 g/kg, 0.25 g/kg, or 0.5 g/kg) by gavage. Our results showed that after 50 days of oral administration, TCM herbal extracts prevented alcohol-induced osteopenia demonstrated by μ-CT bone morphological analysis in young adults and middle-aged/old Balb/c male mice. Biochemical analysis demonstrated that chronic alcohol consumption inhibits bone formation and has a neutral impact on bone resorption, suggesting that TCM herbal extracts (Jing extracts) mitigate the alcohol-induced abnormal bone metabolis...
Source: Frontiers in Pharmacology - December 15, 2021 Category: Drugs & Pharmacology Source Type: research
Dismantling Parkinson's disease with herbs: MAO-B inhibitory activity and quantification of chemical constituents using HPLC-MS/MS of Egyptian local market plants
Nat Prod Res. 2021 Dec 13:1-6. doi: 10.1080/14786419.2021.2013836. Online ahead of print.ABSTRACTWithania somnifera, Angelica sinensis, Glycyrrhiza glabra, and Simmondsia chinensis were acquired from the Egyptian market, profiled for their chemical constituents, screened for the in-vitro MAO-B inhibitory activity and evaluated for the total phenolic content. Thirty compounds were characterized in the selected herbs using HPLC-MS/MS. In-vitro MAO-B inhibitory activity and total phenolic content of the acquired herbs were compared with those of a prepared herbal formula consisting of a mixture of equal amounts of the four me...
Source: Natural Product Research - December 13, 2021 Category: Biochemistry Authors: Soha Ramadan Manal M Sabry Muhammed A Saad Simone Angeloni Omar M Sabry Giovanni Caprioli Soheir M El Zalabani Source Type: research
Induction of PI3K/Akt-Mediated Apoptosis in Osteoclasts Is a Key Approach for Buxue Tongluo Pills to Treat Osteonecrosis of the Femoral Head
This study explored the pharmacodynamic basis and mechanism of BTP against ONFH from the perspective of systemic pharmacology, laying a foundation for further elucidating the therapeutic effects of BTP against ONFH. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 29, 2021 Category: Drugs & Pharmacology Source Type: research
