Exploring the Q-markers of Angelica sinensis (Oliv.) Diels of anti-platelet aggregation activity based on spectrum-effect relationships

In this study, the RAS from geoherb regions showed better efficacy in inhibiting ADP-induced or AA-induced platelet aggregation than those in non-geoherbs. In addition, the HPLC fingerprints of 30 batches of RAS, realizing the comprehensive evaluation of RAS, were established and used for spectral efficiency to screen the quality markers (Q-Markers) on anti-platelet aggregation activities. Five compounds in RAS, senkyunolide I, uridine, guanine, ferulic acid, and adenosine, were demonstrated to contribute significantly to the anti-platelet aggregation activity. These bioactive compounds, especially senkyunolide I and ferulic acid with stronger activities, could be used as Q-Markers of RAS for quality control of RAS. [KEYWORDS: Angelica sinensis; Q-Markers; anti-platelet aggregation; senkyunolide I; ferulic acid.PMID:35677958 | DOI:10.1002/bmc.5422
Source: Biomedical Chromatography : BMC - Category: Biomedical Science Authors: Source Type: research