Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice.

In this study, we used an aging model, SAMP8 mice to investigate the neuroprotective effect of ligustilide. The behavioral tests (Morris water maze, object recognition task, open field test and elevated plus maze) results showed that ligustilide could improve the memory deficit in SAMP8 mice. For mechanism study, we found that the protein level of P-Drp1 (fission) was decreased and the levels of Mfn1 and Mfn2 (fusion) were increased after ligustilide treatment in animals and cells. Ligustilide increased P-AMPK and ATP levels. Malondialdehyde and superoxide dismutase activity results indicated that ligustilide exerts antioxidant effects by reducing the level of oxidative stress markers. In addition, ligustilide improved neural function and alieved apoptosis and neuroinflammation. These findings have shown that ligustilide treatment improves mitochondrial function in SAMP8 mice, and improves memory loss.
PMID: 32065782 [PubMed - as supplied by publisher]

Source: Aging - February 15, 2020 Category: Biomedical Science Authors: Zhu WL, Zheng JY, Cai WW, Dai Z, Li BY, Xu TT, Liu HF, Liu XQ, Wei SF, Luo Y, Wang H, Pan HF, Wang Q, Zhang SJ Tags: Aging (Albany NY) Source Type: research