Prognostic value of the high-sensitivity troponin T assay after percutaneous intervention of chronic total occlusions
Conclusion In patients undergoing CTO-PCI, postprocedural hs-TnT elevation is frequent, but is not correlated with higher MACCE and mortality rates after 1-year FU in our small study population, suggestive of the limited long-term impact of troponin elevation. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - June 22, 2018 Category: Cardiology Tags: Research articles: Interventional cardiology Source Type: research

Comparison of the effects of tolvaptan and furosemide on renal water and sodium excretion in patients with heart failure and advanced chronic kidney disease: a subanalysis of the K-STAR study
ConclusionsAdd-on TLV may increase both renal water and Na excretion in CHF patients with advanced CKD to a greater degree than increased FUR. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 22, 2018 Category: Urology & Nephrology Source Type: research

Budget Impact Analysis of Oral Fisiogen Ferro Forte ® versus Intravenous Iron for the Management of Iron Deficiency in Chronic Kidney Disease in Spain
ConclusionsThe increase in the use of Fisiogen Ferro Forte® leads to overall budget savings of €775,464 for the Spanish National Health Service over 4 years. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - June 22, 2018 Category: Drugs & Pharmacology Source Type: research

Contemporary rates and predictors of fast progression of chronic kidney disease in adults with and without diabetes mellitus
Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether fac... (Source: BMC Nephrology)
Source: BMC Nephrology - June 22, 2018 Category: Urology & Nephrology Authors: Alan S. Go, Jingrong Yang, Thida C. Tan, Claudia S. Cabrera, Bergur V. Stefansson, Peter J. Greasley and Juan D. Ordonez Tags: Research article Source Type: research

Practice patterns in transitioning patients from chronic kidney disease to dialysis: a survey of United States nephrologists
There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patien... (Source: BMC Nephrology)
Source: BMC Nephrology - June 22, 2018 Category: Urology & Nephrology Authors: Mary C. Mallappallil, Steven Fishbane, Rimda Wanchoo, Edgar Lerma, Andrea Roche-Recinos and Moro Salifu Tags: Research article Source Type: research

Role of Bisphosphonates in Vascular calcification and Bone Metabolism: A Clinical Summary.
Authors: Dayanand P, Sandhyavenu H, Dayanand S, Martinez J, Rangaswami J Abstract Vascular calcification is known to be a strong risk factor for cardiovascular adverse events and mortality. Atherosclerosis, diabetes, aging, abnormal bone mineral homeostasis and high uremic milieu such as chronic kidney disease are major factors that contribute to the progression of vascular calcification. Several mechanisms such as the osteoblastic transition of vascular smooth muscle cells in response to oxidative stress have shed light on the active nature of vascular calcification, which was once thought to be a passive process....
Source: Current Cardiology Reviews - June 21, 2018 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research

Increased Fatty Acid Oxidation in Differentiated Proximal Tubular Cells Surviving a Reversible Episode of Acute Kidney Injury
Conclusions: These data suggest that in differentiated proximal tubules energetic hyperactivity is promoted concurrently with organ fibrogenesis.Cell Physiol Biochem 2018;47:1338 –1351 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - June 21, 2018 Category: Cytology Source Type: research

Primary Versus Secondary Prevention of Chronic Kidney Disease: The Case of Dietary Protein
The proclamation that “the greatest medicine of all is to teach people how not to need it” (Hippocrates. 460-370 BC, Greece) is the basic principle of primary disease prevention, which aims to prevent disease before it ever occurs. Preventing exposures to hazards that cause disease, such as altering unhealthy behavio rs, is one example of primary disease prevention. Secondary or tertiary disease prevention, however, refers to reducing the impact of a disease that has already occurred, or limiting the impact of an ongoing illness that has lasting effects, respectively. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - June 21, 2018 Category: Urology & Nephrology Authors: Jaimon T. Kelly, Katrina L. Campbell, Juan J. Carrero Tags: Editorial Source Type: research

Chronic kidney disease in Spain: Prevalence and impact of accumulation of cardiovascular risk factors.
Authors: Gorostidi M, Sánchez-Martínez M, Ruilope LM, Graciani A, de la Cruz JJ, Santamaría R, Del Pino MD, Guallar-Castillón P, de Álvaro F, Rodríguez-Artalejo F, Banegas JR Abstract BACKGROUND: Chronic kidney disease (CKD) is a public health problem worldwide. We aimed to estimate the CKD prevalence in Spain and to examine the impact of the accumulation of cardiovascular risk factors (CVRF). MATERIAL AND METHODS: We performed a nationwide, population-based survey evaluating 11,505 individuals representative of the Spanish adult population. Information was collected th...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - June 21, 2018 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Improving Global Kidney Health: International Society of Nephrology Initiatives and the Global Kidney Health Atlas
Background: Chronic Kidney Disease (CKD) is a major public health problem and is increasingly being recognized as an important driver of costs in all health care systems. The diversity of outcomes for people living with CKD is in part due to variability in biology, access to care, environmental factors, and health care system differences. The International Society of Nephrology (ISN), working in collaboration with its partners, has evolved into a philanthropic organization, from a traditional medical society, committed to a vision that sees “a future where all people have access to sustainable kidney health”. A...
Source: Annals of Nutrition and Metabolism - June 20, 2018 Category: Nutrition Source Type: research

The Vasopressin System in the Risk of Diabetes and Cardiorenal Disease, and Hydration as a Potential Lifestyle Intervention
Background: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention.Summary: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline. Furthermore, we recently showed that increased plasma copeptin concentration independe...
Source: Annals of Nutrition and Metabolism - June 20, 2018 Category: Nutrition Source Type: research

Vasopressin and Diabetic Kidney Disease
Background: Diabetic nephropathy has become the most common cause of chronic kidney disease (CKD). Despite the progress accomplished in therapy, the prevalence of renal disorders remains high. Some modifiable factors driving the increase in incidence of CKD, in diabetes and other settings, might have been overlooked. Consistent evidence supports a role for vasopressin, hydration state, and urine concentration in kidney health.Summary: Plasma vasopressin is elevated in diabetes, even if metabolic control is good. Several epidemiological studies have pointed to a positive association between markers of vasopressin secretion ...
Source: Annals of Nutrition and Metabolism - June 20, 2018 Category: Nutrition Source Type: research

The estimated glomerular filtration rate graph: another tool in the management of patients with advanced chronic kidney disease
The risk assessment tool from the recent Kidney Disease: Improving Global Outcomes conference adds another prediction model for the risk of developing advanced chronic kidney disease and potential need for dialysis.1 None of the existing prediction models use a patient ’s rate of loss of estimated glomerular filtration rate (eGFR). Both current eGFR and the magnitude of past eGFR decline contribute substantially to the risk of end-stage renal disease.2 Furthermore, a graph of all previous eGFR values is an effective visual aid for shared decision-making and can be a useful predictor of when clinical events and treatm...
Source: Kidney International - June 20, 2018 Category: Urology & Nephrology Authors: Hugh C. Rayner, Steven Jay Rosansky Tags: Letter to the Editor Source Type: research

FGF23 effects on the heart —levels, time, source, and context matter
Fibroblast growth factor 23 (FGF23) has appeared as a hormone that is massively elevated in patients with chronic kidney disease. Whether FGF23 is a risk factor that associates with cardiac pathologies and cardiovascular mortality, as suggested by a variety of clinical studies, or additionally acts as a causative factor that induces cardiac injury, as more recently indicated by cell culture and animal studies, is under debate and the center of many ongoing experimental studies. (Source: Kidney International)
Source: Kidney International - June 20, 2018 Category: Urology & Nephrology Authors: Christian Faul Tags: Commentary Source Type: research

Protein carbamylation: a key driver of vascular calcification during chronic kidney disease
Vascular calcification is a frequent complication of advanced chronic kidney disease. Protein carbamylation is implicated in the acceleration of vascular disease in chronic kidney disease, but the mechanisms are not  clear. Mori et al. report that protein carbamylation exacerbates vascular calcification by decreasing ectonucleotide pyrophosphate/phosphodiesterase 1 expression, owing to carbamylation of mitochondrial proteins and oxidative stress. This provides new insight into the pathways responsible for cal cification in chronic kidney disease. (Source: Kidney International)
Source: Kidney International - June 20, 2018 Category: Urology & Nephrology Authors: Clare L. Hawkins Tags: Commentary Source Type: research

AKI in the very elderly patients without preexisting chronic kidney disease: a comparison of 48-hour window and 7-day window for diagnosing AKI using the KDIGO criteria
(Source: Clinical Interventions in Aging)
Source: Clinical Interventions in Aging - June 20, 2018 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research

The role of kidney in the inter-organ coordination of endogenous glucose production during fasting
Conclusions A diminution in renal gluconeogenesis that is accompanied by a decrease in blood vitamin D promotes a novel repartition of EGP among glucose producing organs during fasting, featured by increased intestinal gluconeogenesis that leads to sparing glycogen stores in the liver. Our data suggest a possible involvement of a crosstalk between the intestine and liver (via a neural gut-brain-liver axis) and the kidneys and intestine (via the vitamin D system), which might take place in the situations of deficient renal glucose production, such as chronic kidney disease. (Source: Molecular Metabolism)
Source: Molecular Metabolism - June 20, 2018 Category: Endocrinology Source Type: research

Yonsei nomogram: A predictive model of new ‐onset chronic kidney disease after on‐clamp partial nephrectomy in patients with T1 renal tumors
International Journal of Urology, EarlyView. (Source: International Journal of Urology)
Source: International Journal of Urology - June 20, 2018 Category: Urology & Nephrology Authors: Ali Abdel Raheem , Tae Young Shin , Ki Don Chang , Glen Denmer R Santok , Mohamed Jayed Alenzi , Young Eun Yoon , Won Sik Ham , Woong Kyu Han , Young Deuk Choi , Koon Ho Rha Source Type: research

Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease
Publication date: Available online 19 June 2018 Source:Nitric Oxide Author(s): Xiaoong Liu, Xin Xu, Ruru Shang, Yingjie Chen Patients with chronic kidney disease have an increased cardiovascular morbidity and mortality. It has been recognized that the traditional cardiovascular risk factors could only partially explain the increased cardiovascular morbidity and mortality in patients with chronic kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide production and enhance reactive oxidative specie generation. In...
Source: Nitric Oxide - June 20, 2018 Category: Chemistry Source Type: research

Chronic kidney disease and arrhythmias: highlights from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Patients with chronic kidney disease (CKD) are predisposed to heart rhythm disorders, including atrial fibrillation (AF)/flutter, supraventricular tachycardias, ventricular arrhythmias, and sudden cardiac death (SCD). This population is also historically underrepresented in clinical trials of treatment for heart rhythm disorders.1 (Source: Kidney International)
Source: Kidney International - June 20, 2018 Category: Urology & Nephrology Authors: Christoph Wanner, Charles A. Herzog, Mintu P. Turakhia, Conference Steering Committee Tags: Nephrology Digest Source Type: research

The effect of periodontal disease treatment in patients with continuous ambulatory peritoneal dialysis
ConclusionPeriodontal disease is an important source of inflammation in diabetic CAPD patients and treatment of periodontal disease can be monitored by inflammatory markers including TNF-alpha, PTX-3, IL-6, and Hs-CRP. TNF-alpha may be useful and more sensitive monitoring inflammation in healthy patients and diabetic patients after periodontal treatment. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 20, 2018 Category: Urology & Nephrology Source Type: research

Degludec is effective and safe in real ‐life treatment for patients with type 2 diabetes mellitus and chronic kidney disease stage 3B
International Journal of Clinical Practice,Volume 72, Issue 6, June 2018. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - June 20, 2018 Category: Internal Medicine Authors: Maria Dolores Garcia de Lucas , Julian Olalla Sierra , Beatriz Aviles Bueno Source Type: research

Arterial Stiffness in CKD: A Review
Publication date: Available online 19 June 2018 Source:American Journal of Kidney Diseases Author(s): Raymond R. Townsend This narrative review summarizes a decade of experience examining the cross-sectional and longitudinal relationships of arterial stiffness, as assessed using carotid-femoral pulse wave velocity, with outcomes in patients with chronic kidney disease enrolled in the Chronic Renal Insufficiency Cohort. Our goal is to review the importance of the pulse wave contour and pulse wave velocity and present data on the reproducibility of pulse wave velocity measurements, determinants of pulse wave velocity, and t...
Source: American Journal of Kidney Diseases - June 19, 2018 Category: Urology & Nephrology Source Type: research

Targeting Cardiovascular Disease in Patients with Chronic Kidney Disease: Is Primary Prevention with Aspirin Ready for Prime Time?
(Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - June 19, 2018 Category: Cardiology Source Type: research

A quick scoping review of efficacy, safety, economic, and health-related quality-of-life outcomes of short- and long-acting erythropoiesis-stimulating agents in the treatment of chemotherapy-induced anemia and chronic kidney disease anemia
Anemia is a condition characterized by a deficiency of red blood cells (RBCs) or hemoglobin (Hb), resulting in a diminished capacity of the blood to carry and deliver oxygen to tissues and organs (Abbasi et al., 2014). Anemia is often multifactorial in etiology and may be patient- (e.g., iron-deficiencies, vitamin deficiencies), disease- (e.g., bone marrow diseases, chronic diseases, hemorrhage), or anticancer treatment- (e.g., chemotherapy, radiotherapy, precision therapies) related (Crathorne et al., 2016). (Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - June 19, 2018 Category: Cancer & Oncology Authors: Luiz H. Arantes, Jeffrey Crawford, Pere Gascon, Mark Latymer, Vincent Launay-Vacher, Catherine Rolland, Florian Scotte, Jay Wish Source Type: research

Patterns of glucose-lowering medication use in patients with type 2 diabetes and heart failure. Insights from the diabetes collaborative registry (DCR)
Conclusion In a large US-based outpatient registry, we found that a quarter of adults with T2D had a diagnosis of HF, which was predominantly HFpEF. Although certain T2D medication use in patients with HF appeared consistent with evidence (less use of thiazolidinediones), others appeared contrary to evidence (less use of metformin and SGLT2 inhibitors). (Source: American Heart Journal)
Source: American Heart Journal - June 19, 2018 Category: Cardiology Source Type: research

Representation of Patients With Chronic Kidney Disease in Trials of Cancer Therapy
This study characterizes the exclusion of patients with chronic kidney disease (CKD) in randomized clinical trials of drug treatment for bladder, breast, colorectal, lung, and prostate cancer. (Source: JAMA)
Source: JAMA - June 19, 2018 Category: General Medicine Source Type: research

Biosimilar Approved for Anemia
The first biosimilar to epoetin alfa for patients with anemia from chronic kidney disease, chemotherapy, or zidovudine treatment for HIV infection has receivedFDA approval. (Source: JAMA)
Source: JAMA - June 19, 2018 Category: General Medicine Source Type: research

Progression of Chronic Kidney Disease Affects HDL Impact on Lipoprotein Lipase (LPL)-Mediated VLDL Lipolysis Efficiency
Conclusion: The progression of CKD affects lipoprotein composition and properties, and modulates the positive impact of HDL on VLDL lipolysis efficiency. In CKD patients, HDL deficiency and dysfunction can directly affect hypertriglyceridaemia development.Kidney Blood Press Res 2018;43:970 –978 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 18, 2018 Category: Urology & Nephrology Source Type: research

Short-term weight loss reverses obesity-induced microvascular endothelial dysfunction
AbstractObesity is one of the major risk factors for cardiovascular diseases and its prevalence is increasing in all age groups, with the biggest impact observed in middle-aged and older adults. A critical mechanism by which obesity promotes vascular pathologies in these patients involves impairment of endothelial function. While endothelial dysfunction in large vessels promotes atherogenesis, obesity-induced microvascular endothelial dysfunction impairs organ perfusion and thereby is causally related to the pathogenesis of ischemic heart disease, chronic kidney disease, intermittent claudication, exercise intolerance, and...
Source: AGE - June 18, 2018 Category: Geriatrics Source Type: research

Progression of diabetes, ischemic heart disease, and chronic kidney disease in a three chronic conditions multistate model
Diabetes mellitus, ischemic heart disease, and chronic kidney disease are three major chronic conditions that develop with increasing risks among adults as they get older. The interconnectedness of these three... (Source: BMC Public Health)
Source: BMC Public Health - June 18, 2018 Category: Consumer Health News Authors: Chathura Siriwardhana, Eunjung Lim, James Davis and John J. Chen Tags: Research article Source Type: research

The value of the Brazilian a çai fruit as a therapeutic nutritional strategy for chronic kidney disease patients
AbstractA çai (Euterpe oleracea Mart.) fruit from the Amazon region in Brazil contains bioactive compounds such as α-tocopherol, anthocyanins (cyanidin 3-glycoside and cyanidin 3-rutinoside), and other flavonoids with antioxidant and anti-inflammatory properties. Moreover, the prebiotic activity of anthocyanins in modulating the composition of gut microbiota has emerged as an additional mechanism by which antho cyanins exert health-promoting effects. Açai consumption may be a nutritional therapeutic strategy for chronic kidney disease (CKD) patients since these patients present with oxidative stress, in...
Source: International Urology and Nephrology - June 18, 2018 Category: Urology & Nephrology Source Type: research

Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults
Existing evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and the risk of chronic kidney disease (CKD). We prospectively examined the association between ch... (Source: BMC Medicine)
Source: BMC Medicine - June 18, 2018 Category: Internal Medicine Authors: Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Chenxi Qin, Ling Yang, Yiping Chen, Li Yin, Hui Li, Jian Lan, Junshi Chen, Zhengming Chen, Jun Lv and Liming Li Tags: Research article Source Type: research

Acute Kidney Injury Due to Diarrheal Illness Requiring Hospitalization: Data from the National Inpatient Sample
ConclusionAcute kidney injury is common and consequential among patients hospitalized for diarrheal illness. Persons with CKD and hypertension are the most susceptible, possibly due to diminished renal reserve and exacerbating effects of treatment with diuretics and renin-angiotensin-aldosterone system blockers. Proactive management of these unique pharmacologic and physiologic factors is necessary to prevent AKI in this vulnerable population. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - June 18, 2018 Category: Internal Medicine Source Type: research

The impact of preoperative chronic kidney disease on outcomes after Crawford extent II thoracoabdominal aortic aneurysm repairs
Patients with chronic kidney disease (CKD) who undergo thoracoabdominal aortic aneurysm (TAAA) repair are vulnerable to worse postoperative outcomes. We sought to determine whether preoperative CKD predicts poor outcomes in patients who undergo Crawford extent II TAAA repair. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - June 18, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Joseph S. Coselli, Hiruni S. Amarasekara, Qianzi Zhang, Ourania Preventza, Kim I. de la Cruz, Subhasis Chatterjee, Matt D. Price, Susan Y. Green, Scott A. LeMaire Source Type: research

Impact of statin-ezetimibe combination on coronary atheroma plaque in patients with and without chronic kidney disease — Sub-analysis of PRECISE-IVUS trial
Chronic kidney disease (CKD) deteriorates the prognosis of patients undergoing percutaneous coronary intervention (PCI). Because coronary artery disease (CAD) is the major cause of death in CKD patients, cardiovascular risk reduction has been clinically important in CKD. We hypothesized intensive lipid-lowering with statin/ezetimibe attenuated coronary atherosclerotic development even in patients with CKD. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 18, 2018 Category: Cardiology Authors: Koichiro Fujisue, Suguru Nagamatsu, Hideki Shimomura, Takuro Yamashita, Koichi Nakao, Sunao Nakamura, Masaharu Ishihara, Kunihiko Matsui, Nobuyasu Yamamoto, Shunichi Koide, Toshiyuki Matsumura, Kazuteru Fujimoto, Ryusuke Tsunoda, Yasuhiro Morikami, Koshi Tags: Short communication Source Type: research

Identification and Stratification of Diabetic Kidney Disease Using Serum Cystatin C and Serum Creatinine Based Estimating Equations in Type 2 Diabetes: A Comparative Analysis.
Authors: Avinash S, Singh VP, Agarwal AK, Chatterjee S, Araya V Abstract Background: Cystatin C is a low molecular weight protein produced by all nucleated human cells, with a stable production rate. Its levels are not influenced by inflammation, infections, hepatic or renal diseases, or by dietary or constitutional factors. We compared serum cystatin C and serum creatinine based predicting equations to estimate glomerular filteration rate (GFR) in type 2 diabetes mellitus, using the staging of chronic kidney disease (CKD) defined by the National Kidney Foundation. We also explored the relationship of urine albumin...
Source: Journal of the Association of Physicians of India - June 17, 2018 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Dietary protein and nutritional supplements in conventional hemodialysis.
Abstract Protein energy wasting (PEW) is a condition commonly occurring among patients with ESRD on hemodialysis. PEW is characterized by depletion of protein and energy stores and is caused by multiple factors related to chronic kidney disease, acute and chronic comorbidities and by renal replacement therapy itself. Anorexia is central in the pathogenesis of PEW; it is frequently observed in these patients whose protein and energy intakes are typically lower than guidelines recommendations. If untreated, PEW invariably leads to major complications, and may activate a vicious circle with further worsening of nutri...
Source: Seminars in Dialysis - June 17, 2018 Category: Urology & Nephrology Authors: Sabatino A, Piotti G, Cosola C, Gandolfini I, Kooman JP, Fiaccadori E Tags: Semin Dial Source Type: research

Acquired hypophosphatemic osteomalacia is easily misdiagnosed or neglected by rheumatologists: A report of 9 cases.
In conclusion, diagnosing HO is challenging for rheumatologists and physicians. Basic examinations of electrolyte balance and bone mineral density should be performed, as should tumor screening and a careful collection of patient medical history and drugs in young patients with unexplained thoracic or back pain and muscle weakness. Removing any secondary etiology, such as drugs may dramatically improve the patients clinical manifestations and result in an improved prognosis. PMID: 29904418 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - June 16, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

The Development of a Machine Learning Inpatient Acute Kidney Injury Prediction Model*
Conclusions: Readily available electronic health record data can be used to predict impending acute kidney injury prior to changes in serum creatinine with excellent accuracy across different patient locations and admission serum creatinine. Real-time use of this model would allow early interventions for those at high risk of acute kidney injury. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 16, 2018 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Mortality Predictors of ARDS in Medical Intensive Care Unit of a Tertiary Care Centre in a Tropical Country
Conclusion: Tropical diseases like malaria, dengue, and leptospirosis were the main factors responsible for ARDS. LIS, Modified LIS and PaO2/FiO2 ratio predicted outcome as well as need for mechanical ventilation. Renal failure, metabolic acidosis appeared to be good predictors of mortality. PMID: 29897698 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - June 16, 2018 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

CKD and Sedentary Time: Results From  the Canadian Health Measures Survey
Conclusions In this cross-sectional survey, reduced eGFR was strongly and independently associated with greater sedentary time. This risk was further heightened by the presence of diabetes and arthritis. Studies to determine causes for sedentary behavior and assess the feasibility and value of interventions to reduce sedentary time in CKD are needed. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - June 16, 2018 Category: Urology & Nephrology Source Type: research

Increased NGAL level associated with iron store in chronic kidney disease with anemia
AbstractAn iron scarcity often occurs in chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of acute kidney injury, is associated with iron metabolism. The present study determined the association between serum NGAL and iron status in chronic kidney disease with anemia. A total of 154 adult CKD patients were divided into anemia and without anemia groups. The anemia groups were further subdivided into two groups based on the presence or absence of iron deficiency, defined as a transferrin saturation (TSAT)  
Source: Clinical and Experimental Medicine - June 16, 2018 Category: Research Source Type: research

What is the Role of Soluble Urokinase-Type Plasminogen Activator in Renal Disease?
Context: Soluble urokinase-type plasminogen activator ­(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945–953] it has been found that there is a link between suPAR and renal disease in several guises, and a key question is whe ther it is a driver or a marker of renal disease, and if so of which types of kidney damage.Subject of Review: Circulating suPAR has been postulated to cause acute proteinuric kidney disease, specifically focal segmental glomerulosclerosis (FSGS), though both the anim...
Source: Nephron - June 15, 2018 Category: Urology & Nephrology Source Type: research

Comments on Chronic Kidney Disease, Basal Insulin Glargine, and Health Outcomes in People with Dysglycemia: The Origin Study
I was interested to read the paper by Papademetriou et al1 published in the December 2017 issue of The American Journal of Medicine. I would like to congratulate the authors on their published results in the high-quality journal The American Journal of Medicine. However, several methodological issues should be considered. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - June 15, 2018 Category: General Medicine Authors: Saeid Safiri Tags: Letter Source Type: research

Association of renal function with bone mineral density and fracture risk in the Longitudinal Aging Study Amsterdam
ConclusionsIn men and women, early decreased renal function (eGFR
Source: Osteoporosis International - June 15, 2018 Category: Orthopaedics Source Type: research

Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation
Publication date: Available online 15 June 2018 Source:Pharmacological Research Author(s): Gregory J. Weber, Jaleyea Foster, Sathnur B. Pushpakumar, Utpal Sen Hypertension affects nearly one third of the adult US population and is a significant risk factor for chronic kidney disease (CKD). An expanding body of recent studies indicates that gut microbiome has crucial roles in regulating physiological processes through, among other mechanisms, one mode of short chain fatty acids (SCFA) and their target receptors. In addition, these SCFA receptors are potential targets of regulation by host miRNAs, however, the mechanisms th...
Source: Pharmacological Research - June 15, 2018 Category: Drugs & Pharmacology Source Type: research

Prognostic effect of renal function in ambulatory patients with HFrEF: the kidney is a marker of cardiac function
Conclusion Time-varying kidney function is not independently related to poor prognosis in HF. Rather than directly affecting survival, renal impairment is probably a surrogate marker of HF severity. Teaser Renal impairment has been considered a negative prognostic factor in heart failure (HF). The evidence comes from studies investigating the role of baseline kidney function (KF) or comparing KF and worsening renal function at different time points. We studied the impact of KF on long term prognosis of ambulatory HF patients, taking into account its time-varying effect. We found an association between poorer KF over time a...
Source: Canadian Journal of Cardiology - June 15, 2018 Category: Cardiology Source Type: research

Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial
This study is registered with ClinicalTrials.gov, number NCT01621178. Findings Between Aug 15, 2012, and Nov 30, 2015, 577 patients were randomly assigned, 193 to dulaglutide 1·5 mg, 190 to dulaglutide 0·75 mg, and 194 to insulin glargine. The effects on HbA1c change at 26 weeks of dulaglutide 1·5 mg and 0·75 mg were non-inferior to those of insulin glargine (least squares mean [LSM] −1·2% [SE 0·1] with dulaglutide 1·5 mg [183 patients]; −1·1% [0·1] with dulaglutide 0·75 mg [180 patients]; −1·1% [0·1] with insulin glargine...
Source: The Lancet Diabetes and Endocrinology - June 15, 2018 Category: Endocrinology Source Type: research

Depression and psychological distress in patients with chronic renal failure: Prevalence and associated factors in a rural district in Sri Lanka
Chronic Kidney Disease (CKD) is known to adversely affect mental health. The study was aimed at estimating the prevalence of depression and psychological distress and the associated factors among CKD patients living in Anuradhapura, a rural district in Sri Lanka. (Source: Journal of Psychosomatic Research)
Source: Journal of Psychosomatic Research - June 15, 2018 Category: Psychiatry & Psychology Authors: Sameera Senanayake, Nalika Gunawardena, Paba Palihawadana, Chathurie Suraweera, R. Karunarathna, Priyantha Kumara Source Type: research