Determinants and prevention of coronary disease in patients with chronic kidney disease
Publication date: Available online 25 May 2019Source: Canadian Journal of CardiologyAuthor(s): Rebecca Rodin, Christopher T. ChanAbstractChronic kidney disease (CKD) is associated with premature cardiovascular morbidity and mortality. Traditional Framingham risk factors contribute partially to the malignant form of cardiovascular disease (CVD) in CKD. Uremic specific risk factors including: chronic inflammation, retention of uremic toxins and abnormal bone mineral metabolism have independently been linked to the pathogenesis of premature vascular aging, atherosclerosis, and CVD. This review will explore the mechanisms by w...
Source: Canadian Journal of Cardiology - May 26, 2019 Category: Cardiology Source Type: research

Hypertensive retinopathy and associated factors among nondiabetic chronic kidney disease patients seen at a tertiary hospital in Tanzania: a cross-sectional study.
Authors: Chillo P, Ismail A, Sanyiwa A, Ruggajo P, Kamuhabwa A Abstract Background: Hypertensive retinopathy is a known marker of cardiovascular disease, and among unselected patients with chronic kidney disease (CKD) more severe retinopathy has been associated with lower estimated glomerular filtration rate (eGFR). This association has, however, not been widely studied among nondiabetic hypertensive patients with CKD, especially in sub-Saharan Africa. We aimed to determine the prevalence and severity of hypertensive retinopathy and its relationship with eGFR among nondiabetic CKD patients seen at Muhimbili Nationa...
Source: International Journal of Nephrology and Renovascular Disease - May 25, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Patients with chronic kidney disease and diabetes mellitus: How is health care?
ConclusionsPatients in intermediate stages do not receive follow-up with a multidisciplinary team at the recommended frequency. The preventive approach of the progression of renal disease in the intermediate stage in the studied municipality was not within the recommendations of the Ministry of Health. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 25, 2019 Category: Endocrinology Source Type: research

Growing a new human kidney
There are three reasons to generate a new human kidney. The first is to learn more about the biology of the developing and mature organ. The second is to generate tissues with which to model congenital and acquired kidney diseases. In particular, growing human kidneys in this manner should ultimately help to understand the mechanisms of common chronic kidney diseases such as diabetic nephropathy and others featuring fibrosis, as well as nephrotoxicity. The third is to provide functional kidney tissues that can be directly used in regenerative medicine therapies. (Source: Kidney International)
Source: Kidney International - May 25, 2019 Category: Urology & Nephrology Authors: Adrian S. Woolf. Tags: Review Source Type: research

Mesenchymal Stromal Cells (Cyto-MSC) are Well-tolerated and Associated with Renal Function Improvement in Patients with Chronic Kidney Disease: An Observational Retrospective Study
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1...
Source: Cytotherapy - May 24, 2019 Category: Cytology Source Type: research

GSE121862 A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys
Contributors : Blue B Lake ; Song Chen ; Masato Hoshi ; Nongluk Plongthongkum ; Kun Zhang ; Sanjay JainSeries Type : Expression profiling by high throughput sequencingOrganism :Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (snDrop-Seq) that we use to resolve thirty distinct cell populations in human adult kidney. We define molecular transition states along more than ten nephron segments spanning two major kidney region...
Source: GEO: Gene Expression Omnibus - May 24, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

Lipase and factor V (but not viral load) are prognostic factors for the evolution of severe yellow fever cases.
CONCLUSIONS: YF acute severe cases show a generalised involvement of different organs (liver, spleen, heart, kidneys, intestines and pancreas), and different parameters were related to outcome. Factor V and lipase are independent variables associated with death, reinforcing the importance of hemorrhagic events due to fulminant liver failure and pointing to pancreatitis as a relevant event in the outcome of the disease. PMID: 31116245 [PubMed - in process] (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - May 24, 2019 Category: Infectious Diseases Authors: Casadio LVB, Salles APM, Malta FM, Leite GF, Ho YL, Gomes-Gouvêa MS, Malbouisson LMS, Levin AS, de Azevedo Neto RS, Carrilho FJ, Nastri ACSS, Pinho JRR Tags: Mem Inst Oswaldo Cruz Source Type: research

[Number of nephrologists, hemodialysis services, and prevalence trend of chronic kidney disease in the ministry of health of Peru].
Authors: Herrera-Añazco P, Atamari-Anahui N, Flores-Benites V Abstract We conducted a descriptive and ecological study that evaluated the relationship between the prevalence trend of patients with chronic kidney disease (CKD), the number of nephrologists, and the number of hemodialysis services of the Ministry of Health (MINSA). The study was based on a secondary analysis of the care provided by MINSA, the Observatory of Human Resources in Health, and the hemodialysis services registered as Health Service Providers of the Intangible Health Solidarity Fund (FISSAL, in Spanish). The adjusted prevalence of CKD ...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - May 24, 2019 Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research

Intra-individual variability in high density lipoprotein cholesterol and risk of end-stage renal disease: A nationwide population-based study
In this study, the relationship between HDL-C variability and the risk for progression to end-stage renal disease (ESRD) was investigated. (Source: Atherosclerosis)
Source: Atherosclerosis - May 24, 2019 Category: Cardiology Authors: Eun Sil Koh, Minyoung Kim, Mee Kyoung Kim, Kyoungdo Han, Seok Joon Shin, Hyuk-Sang Kwon, Cheol Whee Park, Yong Gyu Park, Sungjin Chung Source Type: research

An in-depth analysis shows a hidden atherogenic lipoprotein profile in non-diabetic chronic kidney disease patients
. (Source: Expert Opinion on Therapeutic Targets)
Source: Expert Opinion on Therapeutic Targets - May 24, 2019 Category: Drugs & Pharmacology Authors: Marcelino Bermudez-Lopez Carles Forne Nuria Amigo Milica Bozic David Arroyo Teresa Bretones Nuria Alonso Serafi Cambray Maria Dolores Del Pino Didac Mauricio Jose Luis Gorriz Elvira Fernandez Jose Manuel Valdivielso Source Type: research

Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study
Conclusions. Our genetic study identified a novel association at NMT2 for CKD and showed for the first time strong associations of the APOL1 variants with ESKD across multi-ethnic populations. Our findings suggest differences in genetic effects across CKD severity and provide information for study design of genetic studies of CKD in diverse populations. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - May 24, 2019 Category: Genetics & Stem Cells Source Type: research

Periodontitis May Be Associated With Chronic Kidney Disease, but Evidence on Causal Association Is Limited
Publication date: Available online 6 May 2019Source: Journal of Evidence Based Dental PracticeAuthor(s): Shanika Nanayakkara, Xiaoyan ZhouArticle Title and Bibliographic InformationThe directional and nondirectional associations of periodontitis with chronic kidney disease: A systematic review and meta-analysis of observational studies. Zhao D, Khawaja AT, Jin L, Li K–Y, Tonetti M, Pelekos G. J Perio Res 2018; 53(5):682-704.Source of FundingThe authors' own institution, University of Hong Kong.Type of Study/DesignSystematic review with meta-analysis of data. (Source: Journal of Evidence Based Dental Practice)
Source: Journal of Evidence Based Dental Practice - May 23, 2019 Category: Dentistry Source Type: research

Thermal disinfection in hemodialysis using the A0 concept as dispenser.
The objective of this review is to know what is available in the literature on the dose of heat disinfection that should be used in hemodialysis and to present our experience with this method at a set dose of 12.000 A0. PMID: 31109712 [PubMed - as supplied by publisher] (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - May 23, 2019 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Management of diabetes mellitus in chronic kidney disease: an overview.
Authors: Garla VV, Kanduri S, Yanes-Cardozo L, Lien LF Abstract Diabetes mellitus (DM) and Chronic Kidney Disease (CKD) are two chronic diseases whose prevalence and co-prevalence are on the rise. CKD is also the most debilitating and expensive complication of DM while management of DM in CKD is most challenging. CKD is developing in much younger patients with DM, and its presentation is also changing. Various methods of glycemic assessment are affected by CKD and dosage of DM medications needs to be adjusted according to the kidney function. One of the significant barriers to glycemic control in DM patients with C...
Source: Minerva Endocrinologica - May 23, 2019 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Mechanism of Glucagon-Like Peptide 1 Improvements in Type 2 Diabetes Mellitus and Obesity
AbstractPurpose of ReviewThe purpose of this review is to emphasize the pivotal role of glucagon-like peptide 1 (GLP-1) in tackling the parallel epidemics of obesity and type 2 diabetes (T2DM).Recent FindingsGLP-1-based therapies and in particular GLP-1 receptor agonists (GLP-1 RA) have proven to be effective in lowering blood glucose and decreasing weight. GLP-1 RA not only mitigate these significant medical burdens but also result in weight loss and weight loss independent factors that decrease cardiovascular disease (CVD) and microvascular complications of T2DM, such as diabetic nephropathy.SummaryGLP-1-based therapies ...
Source: Current Obesity Reports - May 23, 2019 Category: Eating Disorders & Weight Management Source Type: research

Attainment of Guideline-Directed Medical Treatment in Stable Ischemic Heart Disease Patients With and Without Chronic Kidney Disease
AbstractBackgroundStable ischemic heart disease (SIHD) is prevalent in patients with chronic kidney disease (CKD); however, whether guideline-directed medical therapy (GDMT) is adequately implemented in patients with SIHD and CKD is unknown.HypothesisUse of GDMT and achievement of treatment targets would be higher in SIHD patients without CKD than in patients with CKD.MethodsThis was a retrospective study of 563 consecutive patients with SIHD (mean age 67.8  years, 84% Caucasians, 40% females). CKD was defined as an estimated glomerular filtration rate (eGFR) of
Source: Cardiovascular Drugs and Therapy - May 23, 2019 Category: Cardiology Source Type: research

Sex-Specific Mechanisms in Inflammation and Hypertension
AbstractPurpose of ReviewDespite enhanced screening and therapeutic management, hypertension remains the most prevalent chronic disease in the United States and the leading cause of heart disease, chronic kidney disease, and stroke in both men and women. It is widely accepted that hypertension is a pro-inflammatory disease and that the immune system plays a vital role in mediating hypertensive outcomes and end organ damage. Despite known discrepancies in the risk of hypertension development between men and women, preclinical models of immune-mediated hypertension were historically developed solely in male animals, leading ...
Source: Current Hypertension Reports - May 23, 2019 Category: Primary Care Source Type: research

Left atrial strain associated with alterations in cardiac diastolic function in patients with end-stage renal disease
AbstractThe purpose of this study was to investigate the correlation between left atrial (LA) strain and alterations in cardiac diastolic function in patients with end-stage renal disease. 59 patients with stage 5 chronic kidney disease  (CKD5) and 30 healthy controls were enrolled in this study. Patients with CKD5 were divided into three groups, from normal to Grade II diastolic dysfunction. LA longitudinal strain was evaluated using two-dimensional speckle tracking echocardiography. The peak LA longitudinal strain values (PALS) and LA stiffness index were recorded as the main parameters. Comparing with control group...
Source: The International Journal of Cardiovascular Imaging - May 23, 2019 Category: Radiology Source Type: research

Strongyloides stercoralis infection in a patient with rheumatoid arthritis and type 2 diabetes mellitus: a case-based review
AbstractStrongyloides stercoralis (S. stercoralis), a human intestinal nematode, can lead to hyper/disseminated (HD) infection in patients treated with corticosteroids. Here, we report a case of strongyloidiasis in a 58-year-old female with a history of rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). The patient presented with abdominal pain and gastrointestinal (GI) bleeding. Stool was negative for parasitic agents in the first direct smear examination, and the patient with the probable diagnosis ofHelicobacter pylori (H. pylori) infection or Crohn ’s disease received antibiotics and corticosteroids. ...
Source: Clinical Rheumatology - May 23, 2019 Category: Rheumatology Source Type: research

Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies
by Rodrigo M. Carrillo-Larco, Carlos Altez-Fernandez, J. Gonzalo Acevedo-Rodriguez, Karol Ortiz-Acha, Cesar Ugarte-Gil BackgroundLeptospirosis is a worldwide prevalent zoonosis and chronic kidney disease (CKD) is a leading global disease burden. Because of pathophysiological changes in the kidney, it has been suggested that these conditions may be associated. However, the extent of this interaction has not been synthetized. We aimed to systematically review and critically appraise the evidence on the association between leptospirosis and CKD. Methodology/Principal findingsObservational studies with a control group were sel...
Source: PLoS Neglected Tropical Diseases - May 23, 2019 Category: Tropical Medicine Authors: Rodrigo M. Carrillo-Larco Source Type: research

Ethambutol-induced optic neuropathy in renal disorder: a clinico-electrophysiological study.
Abstract OBJECTIVE: To report the spectrum of ethambutol induced optic neuropathy in a group of renal patients with tuberculosis and the role of visual evoked response (VER) in evaluating this disorder. METHODS: Twenty-three renal patients who were started on ethambutol as a part of anti-tubercular treatment for tuberculosis in India, were divided into 4 groups based on glomerular filtration rate (GFR): group 1-chronic kidney disease (CKD) with GFR 30 ≤ 60 mL/min; and group 4-GFR> 60
Source: Canadian Journal of Ophthalmology - May 22, 2019 Category: Opthalmology Authors: Kanaujia V, Jain VK, Sharma K, Agarwal R, Mishra P, Sharma RK Tags: Can J Ophthalmol Source Type: research

Enarodustat, Conversion and Maintenance Therapy for Anemia in Hemodialysis Patients: A Randomized, Placebo-Controlled Phase 2b Trial Followed by Long-Term Trial
Conclusions: Enarodustat corrected and maintained Hb levels in anemic patients with hemodialysis-dependent CKD. Phase 3 studies of enarodustat are currently ongoing.Nephron (Source: Nephron)
Source: Nephron - May 22, 2019 Category: Urology & Nephrology Source Type: research

Voiding cystography: an unusual route of induced hypothyroidism by iodine overdose in two newborns with chronic kidney disease
ConclusionsThese two observations suggest that voiding cystourethrography (VCUG) should be carefully considered in newborns with severe uropathy, particularly in the case of renal insufficiency. If indicated, thyroid function should be monitored in the following weeks, and in case of hypothyroidism treatment should be started. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - May 22, 2019 Category: Urology & Nephrology Source Type: research

Body composition and arterial stiffness in pediatric patients with chronic kidney disease
This study investigated the impact of body composition in the arterial stiffness of children with chronic kidney disease (CKD).MethodsFat mass (FM), fat tissue index (FTI), fat-free mass (FFM), fat-free tissue index (FFTI), and FFTI/FTI were measured in 26 patients and 25 healthy controls by bio-impedance analysis. Data on patient ’s body mass index (BMI) for height-age, serum albumin, glomerular filtration rate (GFR), blood pressure status, and pulse wave velocity (PWV) were collected in patients.ResultsPatients presented lower levels of FM and FFM compared to healthy controls (p = 0.04 andp =&t...
Source: Pediatric Nephrology - May 22, 2019 Category: Urology & Nephrology Source Type: research

Radiographic abnormalities, bladder interventions, and bladder surgery in the first decade of life in children with spina bifida
AbstractBackgroundSpina bifida (SB) patients are at increased risk for hydronephrosis, bladder storage and emptying problems, and renal failure that may require multiple bladder surgeries.MethodsWe retrospectively reviewed patients born with SB 2005 –2009, presenting to our institution within 1 year of birth. Outcomes at 8–11 years old included final renal/bladder ultrasound (RBUS) results, clean intermittent catheterization (CIC) use, anticholinergic use, surgical interventions, and final renal function. We excluded those without follow- up past age 8 and/or no RBUS or fluoroscopic urodynamic images ...
Source: Pediatric Nephrology - May 22, 2019 Category: Urology & Nephrology Source Type: research

Creatinine Versus Cystatin C To Estimate Glomerular Filtration Rate In Adults With Congenital Heart DiseaseResults of the Boston Adult Congenital Heart Disease Biobank
Publication date: Available online 22 May 2019Source: American Heart JournalAuthor(s): Alexander R. Opotowsky, Matthew Carazo, Michael N. Singh, Konstantinos Dimopoulos, David A. Cardona-Estrada, Ahmed Elantably, Sushrut S. Waikar, Finnian R. Mc Causland, Gruschen Veldtman, Jasmine Grewal, Catherine Gray, Brittani N. Loukas, Saurabh RajpalAbstractBackgroundGlomerular filtration rate is a key physiologic variable with a central role in clinical decision-making and a strong association with prognosis in diverse populations. Reduced estimated glomerular filtration rate (eGFR) is common among adults with congenital heart disea...
Source: American Heart Journal - May 22, 2019 Category: Cardiology Source Type: research

Factors associated with late presentation of patients with chronic kidney disease in nephrology consultation in Cameroon-a descriptive cross-sectional study.
Authors: Marie Patrice H, Joiven N, Hermine F, Jean Yves B, Folefack François K, Enow Gloria A Abstract BACKGROUND: Late presentation (LP) of chronic kidney disease (CKD) patients to nephrologist is a serious problem worldwide with persistent high prevalence despite known benefits of early nephrology care. OBJECTIVE: Determine the prevalence and factors associated with LP of CKD patients to nephrologists in Cameroon. METHODS: A cross-sectional study from October 2015 to May 2016 at the nephrology units of the Douala General and Laquintinie hospitals, including all consenting incident CKD patients. Da...
Source: Renal Failure - May 22, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Resveratrol inhibits parathyroid hormone-induced apoptosis in human aortic smooth muscle cells by upregulating sirtuin 1.
Authors: Liu Y, Wu Y, Diao Z, Guo W, Liu W Abstract BACKGROUND: Cardiovascular disease is the leading cause of death in patients with chronic kidney disease, so there is an urgent need to identify therapeutic targets to control the progression of cardiovascular disease. Apoptosis of aortic smooth muscle cells can promote cardiovascular disease, but the role of parathyroid hormone (PTH) and sirtuin 1 in the pathophysiology of apoptosis is still unclear. METHODS: Cultured human aortic smooth muscle cells (HASMCs) were stimulated with 10-6, 10-8, or 10-10 mol/L PTH for different days, apoptosis was measured b...
Source: Renal Failure - May 22, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Association of Fitness With Racial Differences in Chronic Kidney Disease
Publication date: Available online 21 May 2019Source: American Journal of Preventive MedicineAuthor(s): Amanda E. Paluch, Lindsay R. Pool, Tamara Isakova, Cora E. Lewis, Rupal Mehta, Pamela J. Schreiner, Stephen Sidney, Myles Wolf, Mercedes R. CarnethonIntroductionNon-white minorities are at higher risk for chronic kidney disease than non-Hispanic whites. Better cardiorespiratory fitness is associated with slower declines in estimated glomerular filtration rate and a lower incidence of chronic kidney disease. Little is known regarding associations of fitness with racial disparities in chronic kidney disease.MethodsA prospe...
Source: American Journal of Preventive Medicine - May 22, 2019 Category: International Medicine & Public Health Source Type: research

Postpartum care of women with renal disease
Publication date: Available online 30 April 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Camilla Pillay, Katherine ClarkAbstractTwenty-three percent of women with known chronic kidney disease (CKD) have been reported to demonstrate the first decline in kidney function between giving birth and six-weeks postpartum. As such, these women warrant close monitoring during the postpartum period irrespective of their pregnancy journey. Substantial haemodynamic variability during pregnancy and postpartum renders estimated glomerular filtration rate inaccurate, and poorly defined normal ra...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - May 22, 2019 Category: OBGYN Source Type: research

Outcomes of Desidustat Treatment in People with Anemia and Chronic Kidney Disease: A Phase 2 Study
Conclusion: There was dose-related increase in Hb across all doses compared to placebo in mITT and per-protocol populations. Desidustat also increased pharmacokinetic parameters Cmax and AUC in dose-related manner. There was no significant change in vital signs, electrocardiographic parameters, or safety laboratory values. Clinical Trial Registration Number CTRI/2017/05/008534 (registered on May 11, 2017).Am J Nephrol 2019;49:470 –478 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 22, 2019 Category: Neurology Source Type: research

Shen Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and Sirt1/Smad3 deacetylation pathway
Excessive activation of NLRP3 inflammasome and down-regulation of Sirt1/Smad3 deacetylation pathway play a significant role in the evolution of renal fibrosis. In China, it has been well known that Chinese her... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 22, 2019 Category: Complementary Medicine Authors: Meng Wang, Liuyi Yang, Jing Yang and Chen Wang Tags: Research article Source Type: research

New Debates Surrounding the Histopathological Findings of Calciphylaxis
Calciphylaxis, most commonly diagnosed in patients with end-stage renal disease (ESRD) but also affecting patients with normal renal function, is a devastating disease characterized by the development of ischemic skin lesions and associated with substantial patient morbidity and high 1-year mortality rates. Calciphylaxis was thought to be a rare disease; however, in recent years, reports and publications on the topic have increased. Whether this increase is due to a rise in incidence or improved recognition is unclear. Calciphylaxis is primarily a clinical diagnosis, made by the presence of livedoid skin changes or retifor...
Source: JAMA Dermatology - May 22, 2019 Category: Dermatology Source Type: research

Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials
Publication date: Available online 20 May 2019Source: Pharmacological ResearchAuthor(s): C. Michael White, Vinay Pasupuleti, Yuani M. Roman, Yangzhou Li, Adrian V. HernandezAbstractTurmeric extract or active component curcumin may have anti-inflammatory effects in people with chronic inflammatory diseases. The effect of turmeric or curcumin on a wide range of inflammatory markers has not been evaluated in a systematic review. We performed a systematic review of randomized controlled trials (RCTs) evaluating the effects of oral turmeric or curcumin on inflammatory markers (CRP, hsCRP, IL-1, IL-6, TNF) in patients with a wid...
Source: Pharmacological Research - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

VMP35 MNC, a novel iron-free supplement, enhances cytoprotection against anemia in human subjects: a novel hypothesis.
Conclusion: Overall, the non-iron containing VMP35 can induce improvements in blood properties and potential benefits for subjects even with compromised digestive systems. No adverse events were reported. Further research studies are in progress to explore the mechanistic insight. PMID: 31105509 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - May 22, 2019 Category: Nutrition Authors: Corbier JR, Downs BW, Kushner S, Aloisio T, Bagchi D, Bagchi M Tags: Food Nutr Res Source Type: research

Identify potentially inappropriate medications in older adults with chronic kidney disease and deprescribe when possible
AbstractOlder adults with chronic kidney disease (CKD) often receive treatment with multiple medications and are vulnerable to adverse treatment-related outcomes. Although specific guidelines for deprescribing (defined as the process of eliminating or reducing the use of unnecessary and/or inappropriate medications) in older patients with CKD are lacking, a systemic process should be used to assess the individual patient, identify the use of potentially inappropriate medications (PIMs), and deprescribe such medications when possible. Dosage tapering is needed when some commonly used PIMs (e.g. proton pump inhibitors and or...
Source: Drugs and Therapy Perspectives - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

The Influence of Aortic Valve Obstruction on the Hyperemic Intracoronary Physiology: Difference Between Resting Pd/Pa and FFR in Aortic Stenosis
AbstractThe reliability of fractional flow reserve (FFR) in aortic stenosis (AS) has been questioned because of the uncertain response to vasodilators. A retrospective multicenter cohort of 114 AS patients who underwent coronary physiology assessment was compared with 154 controls before and after propensity matching adjustment. The difference between resting distal coronary vs aortic pressure ratio (Pd/Pa) and FFR ( ΔPd/Pa-FFR) was tested against the severity of AS. ΔPd/Pa-FFR was not influenced by the severity of AS in terms of aortic valve area (r = − 0.02,p = 0.83) a...
Source: Journal of Cardiovascular Translational Research - May 22, 2019 Category: Cardiology Source Type: research

Reduced endothelial nitric oxide synthase activation contributes to cardiovascular injury during chronic kidney disease progression.
la NA, Barrera-Chimal J Abstract Major cardiovascular events are a common complication in chronic kidney disease (CKD) patients. Endothelial dysfunction can contribute to the cardiovascular injury observed in CKD. Here, we used a rat model of acute kidney injury to CKD transition to investigate heart alterations in the pathway activating endothelial nitric oxide synthase (eNOS) and its impact on the cardiac injury observed during CKD progression. Fifty male Wistar rats were divided into sham surgery (n=25) or rats subjected to bilateral renal ischemia-reperfusion (IR-CKD) for 45 min (n=25). The rats were studied o...
Source: American Journal of Physiology. Renal Physiology - May 22, 2019 Category: Physiology Authors: Amador-Martínez I, Pérez-Villalva R, Uribe N, Cortés-González C, Bobadilla NA, Barrera-Chimal J Tags: Am J Physiol Renal Physiol Source Type: research

A new mouse model of CKD transitioned from ischemic AKI.
In conclusion, a new model of AKI to CKD transition was generated in C57BL/6 mice. PMID: 31116604 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - May 22, 2019 Category: Physiology Authors: Wei J, Zhang J, Wang L, Jiang S, Fu L, Buggs J, Liu R Tags: Am J Physiol Renal Physiol Source Type: research

Management of hyperkalemia in patients with kidney disease: a position paper endorsed by the Italian Society of Nephrology.
Abstract Hyperkalemia (HK) is the most common electrolyte disturbance observed in patients with kidney disease, particularly in those in whom diabetes and heart failure are present or are on treatment with renin-angiotensin-aldosterone system inhibitors (RAASIs). HK is recognised as a major risk of potentially life threatening cardiac arrhythmic complications. When an acute reduction of renal function manifests, both in patients with chronic kidney disease (CKD) and in those with previously normal renal function, HK is the main indication for the execution of urgent medical treatment and the recourse to extracorpo...
Source: Journal of Nephrology - May 22, 2019 Category: Urology & Nephrology Authors: Bianchi S, Aucella F, De Nicola L, Genovesi S, Paoletti E, Regolisti G Tags: J Nephrol Source Type: research

Association Between Hepatitis C Virus and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
Authors: Fabrizi F, Donato FM, Messa P Abstract INTRODUCTION AND AIM: The role of hepatitis C virus infection as a risk factor for the development and progression of chronic kidney disease in the general population remains unclear. MATERIAL AND METHODS: A systematic review of the published medical literature was performed to assess whether positive anti-HCV serologic status is associated with higher frequency of chronic kidney disease in the adult general population. We used a random-effects model to generate a summary estimate of the relative risk of chronic kidney disease (defined by lowered glomerular filtra...
Source: Annals of Hepatology - May 21, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Wyatt CM, Drueke TB. High-dose IV iron for anemia correction in chronic kidney disease. Kidney Int. 2019;95:727 –730
In the above-stated article, on page 727 at the end of the first paragraph, the sentence “Serum hepcidin levels increase in response to iron overload and decrease in response to inflammation.” should be “Serum hepcidin levels increase in response to iron overload and inflammation.” (Source: Kidney International)
Source: Kidney International - May 21, 2019 Category: Urology & Nephrology Tags: Corrigendum Source Type: research

The Dietary Approaches to Stop Hypertension (DASH) diet in chronic kidney disease: should we embrace it?
The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure and cardiovascular disease risk. In this issue, Banerjee et  al. report that the DASH diet is associated with lower risk of end-stage kidney disease in individuals with stage 3 chronic kidney disease and hypertension. This association was particulary strong among those with diabetes. The DASH diet may have an important role in preventing end-stage kidney di sease in select individuals with chronic kidney disease. (Source: Kidney International)
Source: Kidney International - May 21, 2019 Category: Urology & Nephrology Authors: Kalani L. Raphael Tags: Commentary Source Type: research

In Vivo Detection of Chronic Kidney Disease Using Tissue Deformation Fields From Dynamic MR Imaging
Conclusion: Image registration applied to dynamic time series correlated with structural renal changes and should be further explored as a tool for invasive measurements of arteriosclerosis. Significance: Under the assumption that the proposed framework can be further developed in terms of sensitivity and specificity, it can provide clinicians with a non-invasive tool of high spatial coverage available for characterization of arteriosclerosis and potentially other pathological changes observed in chronic kidney disease. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - May 21, 2019 Category: Biomedical Engineering Source Type: research

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria
Acute kidney injury (AKI) is a recognized complication of pediatric severe malaria, but its long-term consequences are unknown. (Source: BMC Medicine)
Source: BMC Medicine - May 21, 2019 Category: Internal Medicine Authors: Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Richard Idro, John M. Ssenkusu, Dibyadyuti Datta, James S. Hodges, Catherine Morgan and Chandy C. John Tags: Research article Source Type: research

Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function
Conclusions: Bariatric surgery increased miR 192 and miR 200 urinary levels, key anti-fibrotic microRNAs that could contribute to a renal-protective mechanism and may be of value as urinary biomarkers following surgery. These findings suggest that urinary microRNAs may represent potential novel biomarkers for obesity-associated renal function. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - May 21, 2019 Category: Endocrinology Source Type: research

Creating arteriovenous fistulas for children in Guatemala
The Guatemalan Foundation for Children with Kidney Diseases was established in 2003 as the first and only comprehensive pediatric nephrology program and hemodialysis unit in Guatemala. Bridge of Life (BOL) is a not-for-profit charitable organization focused on chronic kidney disease and supplied equipment, training and support during formation of the hemodialysis unit. Pediatric permanent vascular access (VA) expertise had not been established and noncuffed dialysis catheters provided almost all VA, many through subclavian vein access sites. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - May 21, 2019 Category: Surgery Authors: William C. Jennings, Randall Lou-Meda, Nasir Mushtaq, Alexandros Mallios, Sindy M éndez-Soveranis, Raúl Ernesto Sosa Tejada, John F. Lucas, Wayne S. Gradman Source Type: research

Outcomes of Desidustat Treatment in People with Anemia and Chronic Kidney Disease: A Phase 2 Study.
CONCLUSION: There was dose-related increase in Hb across all doses compared to placebo in mITT and per-protocol populations. Desidustat also increased pharmacokinetic parameters Cmax and AUC in dose-related manner. There was no significant change in vital signs, electrocardiographic parameters, or safety laboratory values. Clinical Trial Registration Number CTRI/2017/05/008534 (registered on May 11, 2017). PMID: 31112954 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - May 21, 2019 Category: Urology & Nephrology Authors: Parmar DV, Kansagra KA, Patel JC, Joshi SN, Sharma NS, Shelat AD, Patel NB, Nakrani VB, Shaikh FA, Patel HV, on behalf of the ZYAN1 Trial Investigators Tags: Am J Nephrol Source Type: research

Urinary and Serum Biomarkers for Prediction of Acute Kidney Injury in Patients Undergoing Liver Transplantation.
Abstract Acute kidney injury (AKI) is a frequent and serious complication of orthotopic liver transplantation (OLT), with a significant impact on mortality, graft survival, and chronic kidney disease. Currently, the diagnosis of AKI is based on changes in serum creatinine, which is a late marker, usually rising when there is already significant damage to the renal parenchyma. During the last 2 decades, various biomarkers have been studied in many clinical situations, mostly after cardiac surgery, in drug-induced AKI, or in sepsis. The present article summarizes the data on those biomarkers that have been evaluated...
Source: Annals of Transplantation - May 21, 2019 Category: Transplant Surgery Authors: Lewandowska L, Małyszko J, Joanna Matuszkiewicz-Rowińska J Tags: Ann Transplant Source Type: research

Application of GFR estimation equations in elderly patients with measured GFR below 60  mL/min/1.73 m2.
Application of GFR estimation equations in elderly patients with measured GFR below 60 mL/min/1.73 m2. Aging Clin Exp Res. 2019 May 21;: Authors: Chen A, Sun Y, Li W, Yang J, Yao Z, Shi L, Jia J Abstract BACKGROUND: Estimated glomerular filtration rate (eGFR) equations can be inaccurate when applied to elderly patients. Newly, the full-age-spectrum (FAS) equation was developed for use in elderly patients. AIM: We compared the available eGFR equations in elderly Chinese patients with mGFRs 
Source: Aging Clinical and Experimental Research - May 21, 2019 Category: Geriatrics Authors: Chen A, Sun Y, Li W, Yang J, Yao Z, Shi L, Jia J Tags: Aging Clin Exp Res Source Type: research