Incidence rate of atrial fibrillation after dialysis initiation and its relationship with cardiovascular events.
This study aimed to investigate the incidence of atrial fibrillation (AF) and its prognosis in the patients after dialysis initiation. METHODS: A total of 1524 patients with chronic kidney disease who were initiated on dialysis were included. Dialysis was initiated between October 2011 and September 2013. Electrocardiogram was obtained at dialysis initiation, in March 2015, and September 2016. The mortality and cardiovascular disease (CVD) event rates of 1520 patients (1028 men and 492 women; mean age, 67.5 ± 13.1 years) who were followed up were compared, and they were divided into 2 groups: the AF group (...
Source: Acta Cardiologica - February 23, 2019 Category: Cardiology Tags: Acta Cardiol Source Type: research

Validation of the Patient-Reported Outcomes Measurement Information System (PROMIS)-57 and -29 item short forms among kidney transplant recipients
ConclusionsOur results provide evidence that PROMIS-57 and PROMIS-29 are highly reliable and valid instruments among kidney transplant recipients. We propose it as a valuable tool to assess important domains of the illness experience. (Source: Quality of Life Research)
Source: Quality of Life Research - February 22, 2019 Category: Health Management Source Type: research

Association of Thyrotropin Concentration with Chronic Kidney Disease in a Japanese General Population Cohort
Conclusions: Our data indicate that higher TSH concentrations are positively correlated with CKD prevalence and that  a high TSH concentration is a risk factor for CKD development.Nephron (Source: Nephron)
Source: Nephron - February 22, 2019 Category: Urology & Nephrology Source Type: research

Progressive Decline in Estimated GFR in Patients With Sickle Cell Disease: An Observational Cohort Study
Publication date: Available online 21 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Vimal K. Derebail, Emily J. Ciccone, Qingning Zhou, R. Rosina Kilgore, Jianwen Cai, Kenneth I. AtagaRationale & ObjectiveProgression of chronic kidney disease (CKD) in sickle cell disease (SCD) and its risk factors remain poorly defined. We identified characteristics associated with CKD as well as decline in estimated glomerular filtration rate (eGFR) and presence of proteinuria over time in adults with SCD.Study DesignRetrospective observational study.Setting & ParticipantsPatients with SCD 18 years or older in...
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Fracture status in middle-aged individuals with early CKD: cross-sectional analysis of the CARTaGENE survey
ConclusionsCKD stage 3 was not associated with an increase in fracture status. QUS parameters were similarly associated with fracture status in patients with and without CKD. (Source: Osteoporosis International)
Source: Osteoporosis International - February 22, 2019 Category: Orthopaedics Source Type: research

Latent Tuberculosis Infection and Non-Infectious Co-morbidities: Diabetes Mellitus type 2, Chronic Kidney Disease and Rheumatic Arthritis
The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 22, 2019 Category: Infectious Diseases Authors: Cesar Ugarte-Gil, Rodrigo M. Carrillo-Larco, Daniela E. Kirwan Source Type: research

The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patients
Cardiovascular disease (CVD) remains a leading cause of mortality in chronic kidney disease (CKD) patients. Interventions targeting traditional risk factors have largely proven ineffective in CKD patients in part because of the increased role of nontraditional risk factors such as chronic inflammation. Omega-3 fatty acids ( ω3FA) are inexpensive and safe natural agents, which target inflammation and have potential cardioprotective benefits. The aim of the study was to determine the effects of ω3FA supplementation upon serum interleukin (IL)-12, IL-18, and highly sensitive C-reactive protein (hsCRP) in patients ...
Source: Journal of Renal Nutrition - February 22, 2019 Category: Urology & Nephrology Authors: Kenneth Yong, Trevor Mori, Gerard Chew, Lawrence J. Beilin, Ian Puddey, Gerald F. Watts, Ashley Irish, Gursharan Dogra, Neil Boudville, Wai Lim Tags: Original Research Source Type: research

Prognostic value of the estimated glomerular filtration rate decline in hypertensive patients without chronic kidney disease.
This study comprised 2,516 hypertensive patients who had had at least two serum creatinine measurements over a four-year period. An eGFR reduction of ≥10% per year has been deemed as high-eGFR and a reduction in eGFR of less than 10% per year as a low decline. The end-points were: coronary artery disease, stroke, transitory ischemic accident, peripheral arterial disease, heart failure, atrial fibrillation, death from any cause. Cox regression analyses adjusted for potentially confounding factors were conducted. RESULTS: 2,354 patients with low rate of eGFR decline and 149 with high-rate of eGFR decline were analyze...
Source: American Journal of Hypertension - February 22, 2019 Category: Cardiology Authors: Coll-de-Tuero G, Comas-Cufí M, Rodríguez-Poncelas A, Barrot-de-la Puente J, Blanch J, Figa-Vaello J, Barceló MA, Saez M Tags: Am J Hypertens Source Type: research

Risk factors for hypertension in Canada.
DISCUSSION: Physical activity, diet, body mass index, the presence of diabetes, and the presence of chronic kidney disease were strong risk factors for hypertension. Many of these risk factors are modifiable and highlight targets for future prevention strategies. PMID: 30785634 [PubMed - in process] (Source: Health Reports)
Source: Health Reports - February 21, 2019 Category: International Medicine & Public Health Tags: Health Rep Source Type: research

Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study
Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we exa... (Source: BMC Nephrology)
Source: BMC Nephrology - February 21, 2019 Category: Urology & Nephrology Authors: Xue Bao, Yan Born é, Iram Faqir Muhammad, Christina-Alexandra Schulz, Margaretha Persson, Marju Orho-Melander, Kaijun Niu, Anders Christensson and Gunnar Engström Tags: Research article Source Type: research

Parenteral versus oral iron therapy for adults and children with chronic kidney disease.
CONCLUSIONS: The included studies provide low certainty evidence that IV iron compared with oral iron increases haemoglobin, ferritin and transferrin levels in CKD participants, increases the number of participants who achieve target haemoglobin and reduces ESA requirements. However, there is insufficient evidence to determine whether IV iron compared with oral iron influences death (all causes), cardiovascular death and quality of life though most studies reported only short periods of follow-up. Adverse effects were reported in only 50% of included studies. We therefore suggest that further studies that focus on patient-...
Source: Cochrane Database of Systematic Reviews - February 21, 2019 Category: General Medicine Authors: O'Lone EL, Hodson EM, Nistor I, Bolignano D, Webster AC, Craig JC Tags: Cochrane Database Syst Rev Source Type: research

Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation
Publication date: Available online 19 February 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Laura Ferreras, Anna Moles, Gerhard R. Situmorang, Rana el Masri, Imogen L. Wilson, Katie Cooke, Emily Thompson, Marion Kusche-Gullberg, Romain R. Vivès, Neil S. Sheerin, Simi AliAbstractOne of the main feature of chronic kidney disease is the development of renal fibrosis. Heparan Sulfate (HS) is involved in disease development by modifying the function of growth factors and cytokines and creating chemokine gradients. In this context, we aimed to understand the function of HS sulfation in rena...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 20, 2019 Category: Biochemistry Source Type: research

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics
Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We sought to define the signatures of age on the renal transcriptome using 563 human kidneys. The initial discovery analysis of 260 kidney transcriptomes from the TRANScriptome of renaL humAn TissuE Study (TRANSLATE) and the Cancer Genome Atlas identified 37 age-associated genes. For 19 of those genes, the association with age was replicated in 303 kidney transcriptomes from the Nephroseq resource. (Source: Kidney International)
Source: Kidney International - February 20, 2019 Category: Urology & Nephrology Authors: Joshua Rowland, Artur Akbarov, James Eales, Xiaoguang Xu, John P. Dormer, Hui Guo, Matthew Denniff, Xiao Jiang, Parisa Ranjzad, Alicja Nazgiewicz, Priscilla Ribeiro Prestes, Andrzej Antczak, Monika Szulinska, Ingrid A. Wise, Ewa Zukowska-Szczechowska, Paw Tags: Clinical Investigation Source Type: research

Tubule repair: with a little help from my “unexpected” friends
Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature. (Source: Kidney International)
Source: Kidney International - February 20, 2019 Category: Urology & Nephrology Authors: Letizia De Chiara, Paola Romagnani Tags: Commentary Source Type: research

Executive summary for the 2015 Annual Data Report of  the China Kidney Disease Network (CK-NET)
Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. One major output of CK-NET is to generate an Annual Data Report (ADR) providing resourceful information regarding kidney disease in China. (Source: Kidney International)
Source: Kidney International - February 20, 2019 Category: Urology & Nephrology Authors: Fang Wang, Chao Yang, Jianyan Long, Xinju Zhao, Wen Tang, Dongliang Zhang, Kunhao Bai, Zaiming Su, Bixia Gao, Hong Chu, Jinwei Wang, Xiaoyu Sun, Song Wang, Li Zuo, Yue Wang, Feng Yu, Haibo Wang, Luxia Zhang, Ming-Hui Zhao Tags: Executive Summary Source Type: research

Use of GLP-1 receptor agonists in patients with T2DM and chronic kidney disease
Abstract: Diabetes mellitus is the leading cause of chronic kidney disease (CKD) in the US. An increasing number of glucagon-like peptide-1 receptor agonists are available for diabetes management. Differences between medications in this class, as well as limited data on patients with CKD, underscore the importance of a patient-centered approach to care. (Source: The Nurse Practitioner)
Source: The Nurse Practitioner - February 20, 2019 Category: Nursing Tags: Feature: TYPE 2 DIABETES MELLITUS: CE Connection Source Type: research

Use of GLP-1 receptor agonists in patients with T2DM and chronic kidney disease
No abstract available (Source: The Nurse Practitioner)
Source: The Nurse Practitioner - February 20, 2019 Category: Nursing Tags: CE Connection Source Type: research

Morin has protective potential against ER stress induced apoptosis in renal proximal tubular HK-2 cells
In this study, we investigated the protective effects of flavonoid morin against ER stress induced apoptosis in human renal proximal tubular HK-2 cells. Morin downregulated the expression of GRP78, central regulator of ER stress response, induced by ER stress inducer tunicamycin. Interestingly, morin selectively inhibited the IRE1 pathway among the three major arms of the ER stress responses. The increased expression of XBP1-sp, phosphor-IRE-1α, and phosphor-JNK by TM were markedly suppressed by the pretreatment of morin. Morin also decreased the intracellular ROS production and the apoptosis induced by TM in HK-2 ce...
Source: Biomedicine and Pharmacotherapy - February 20, 2019 Category: Drugs & Pharmacology Source Type: research

Does Kidney Longevity Mean Healthy Vegan Food and Less Meat or Is Any Low-Protein Diet Good Enough?
An increasing number of publications and presentations have recently emerged to reinvigorate the discussion about the role of low-protein diets in improving kidney longevity in persons with chronic kidney disease (CKD). It has been known for decades that intake of protein-rich foods results in dilatation of the afferent arterioles of the glomeruli, leading to elevated intraglomerular pressure and increased glomerular filtration rate. Although the increased glomerular filtration rate appears to enhance kidney function in the short term, chronic glomerular hyperfiltration as a result of frequent high protein intake may have ...
Source: Journal of Renal Nutrition - February 20, 2019 Category: Urology & Nephrology Authors: Kamyar Kalantar-Zadeh, Linda W. Moore Tags: Editorial Source Type: research

Adherence to long-term use of renin-angiotensin II-aldosterone system inhibitors in children with chronic kidney disease
This study aimed to evaluate pat... (Source: BMC Pediatrics)
Source: BMC Pediatrics - February 20, 2019 Category: Pediatrics Authors: Chien-Ning Hsu, Shiou-Huei Huang and You-Lin Tain Tags: Research article Source Type: research

Nattokinase-heparin exhibits beneficial efficacy and safety —an optimal strategy for CKD patients on hemodialysis
AbstractHeparin is a widely used anticoagulant in hemodialysis (HD) for patients with chronic kidney disease (CKD); however, it entails the risk of thrombus formation due to heparin-induced thrombocytopenia. Indeed, CKD patients on HD are associated with excessive mortality from cardiovascular disease due to their prothrombotic profile. Therefore, it would be a significant breakthrough to develop a thrombolytic adjuvant that facilitates heparin to achieve its proper anticoagulant efficiency at a much lower dose for greater safety. Nattokinase (NK), a valuable dietary supplement possessing strong fibrinolytic and thrombolyt...
Source: Glycoconjugate Journal - February 20, 2019 Category: Biochemistry Source Type: research

Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study
Insulin resistance contributes to the metabolic syndrome, which is associated with the development of kidney disease. However, it is unclear if insulin resistance independently contributes to an increased risk... (Source: BMC Nephrology)
Source: BMC Nephrology - February 20, 2019 Category: Urology & Nephrology Authors: Sarah J. Schrauben, Christopher Jepson, Jesse Y. Hsu, F. Perry Wilson, Xiaoming Zhang, James P. Lash, Bruce M. Robinson, Raymond R. Townsend, Jing Chen, Leon Fogelfeld, Patricia Kao, J. Richard Landis, Daniel J. Rader, L. Lee Hamm, Amanda H. Anderson and Tags: Research article Source Type: research

Successful management of pregnancy in recurrent immunoglobin A nephropathy and glomerulosclerosis: A case report
Introduction: Like other kidney diseases, immunoglobulin A nephropathy (IgAN) is increasingly encountered in pregnancy, but obstetric and renal outcomes are controversial. Patients with IgAN are at higher risk of hypertension, preeclampsia, and fetal loss, with worse prognosis in advanced chronic kidney disease and high baseline proteinuria. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 19, 2019 Category: OBGYN Authors: Andrea Carosso, Marina Zonca, Loredana Colla, Chiara Benedetto Tags: Movies – Extra Case Reports – Obstetrics and Prenatal Diagnosis Source Type: research

Refractory exudative pleural effusion in patients with chronic kidney disease not receiving dialysis: A case report
Although exudative pleural effusion can be caused by infections, malignancies, and connective tissue diseases, we need to consider uremic pleural effusion and pleuritis in differential diagnosis of exudative lymphocyte predominant pleural effusion in patients with chronic kidney disease not receiving dialysis. Key Clinical MessageAlthough exudative pleural effusion can be caused by infections, malignancies, and connective tissue diseases, we need to consider uremic pleural effusion and pleuritis in differential diagnosis of exudative lymphocyte predominant pleural effusion in patients with chronic kidney disease not receiv...
Source: Clinical Case Reports - February 19, 2019 Category: General Medicine Authors: Hye Mi Seo, Miyeon Kim, Hyunwoo Kim Tags: CASE REPORT Source Type: research

Morin has protective potential against ER stress induced apoptosis in renal proximal tubular HK-2 cells.
In this study, we investigated the protective effects of flavonoid morin against ER stress induced apoptosis in human renal proximal tubular HK-2 cells. Morin downregulated the expression of GRP78, central regulator of ER stress response, induced by ER stress inducer tunicamycin. Interestingly, morin selectively inhibited the IRE1 pathway among the three major arms of the ER stress responses. The increased expression of XBP1-sp, phosphor-IRE-1α, and phosphor-JNK by TM were markedly suppressed by the pretreatment of morin. Morin also decreased the intracellular ROS production and the apoptosis induced by TM in HK-2 ce...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 19, 2019 Category: Drugs & Pharmacology Authors: Mo JS, Choi D, Han YR, Kim N, Jeong HS Tags: Biomed Pharmacother Source Type: research

Burden, Access, and Disparities in Kidney Disease
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight the need for strengthening basic infrastructure for kidney care services for early detec...
Source: Nephron - February 18, 2019 Category: Urology & Nephrology Source Type: research

Prescribing of diabetes medications to people with type 2 diabetes and chronic kidney disease: a national cross-sectional study
Previous studies in general practice and hospital settings have identified that prescribing of non-insulin diabetes medications may be sub-optimal in people with type 2 diabetes (T2D) and renal impairment. Sin... (Source: BMC Family Practice)
Source: BMC Family Practice - February 18, 2019 Category: Primary Care Authors: Jo-Anne Manski-Nankervis, Sharmala Thuraisingam, Janet K. Sluggett, Gary Kilov, John Furler, David O ’Neal and Alicia Jenkins Tags: Research article Source Type: research

Wide QRS Tachycardia in a Man With a Medical History of Atrial Fibrillation
A man in his 70s with stage 4 chronic kidney disease and atrial fibrillation presented with 1 month of progressive dyspnea on exertion, orthopnea, and worsening lower extremity edema. What is your diagnosis? (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - February 18, 2019 Category: Internal Medicine Source Type: research

Proton pump inhibitors and risk of acute and chronic kidney disease: a retrospective cohort study
This study examined the association between PPI use and risk of incident AKI and CKD in a large, population‐based health‐maintenance organization (HMO) cohort.MethodsPatients aged 18 years or older, without evidence of pre ‐existing renal disease, started on PPI therapy, and continuously enrolled for at least 12 months between July 1993 and September 2008 were identified in an HMO database. Incidences of AKI and CKD were defined using documented International Classification of Disease, Ninth Revision, Clinical Modif ication (ICD‐9‐CM) codes or a glomerular filtration rate less than 60 ml/min/1.73 m2 after initiat...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 18, 2019 Category: Drugs & Pharmacology Authors: Emily Hart, Terry E. Dunn, Steven Feuerstein, David M. Jacobs Tags: Original Research Article Source Type: research

Relationship between plasma YKL-40 levels and endothelial dysfunction in chronic kidney disease
This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements PMID: 30763987 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - February 17, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

The role of sodium glucose cotransporter-2 (SGLT-2) inhibitors in heart failure and chronic kidney disease in type 2 diabetes.
CONCLUSIONS: CVOTs and other studies confirm that the SGLT-2 inhibitors, mostly used in combination with other glucose-lowering drugs, offer several clinical benefits beyond improved glycemic control. These include reducing HHF risk and improving renal outcomes. HF and renal benefits are observed in individuals with and without established CVD, which may simplify therapeutic selection. Ongoing SGLT-2 inhibitor CVOTs will help clarify the potential of these drugs to treat T2D comorbid with different forms of HF (HF with preserved vs reduced ejection fraction) and different degrees of renal dysfunction, and in individuals wi...
Source: Current Medical Research and Opinion - February 17, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Outcome of posterior urethral valve in 64 children. Single center experience of 22 years.
CONCLUSIONS: Our results confirm that PUV has a considerable risk for CKD development. Antenatal diagnosis, management of proteinuria and hypertension may modify this progression. But already injured kidneys still have a potential risk. The need for further research to evaluate the impact of any intervention on long term renal outcome is obvious. PMID: 30767491 [PubMed - as supplied by publisher] (Source: Minerva Urologica e Nefrologica)
Source: Minerva Urologica e Nefrologica - February 17, 2019 Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research

Renal disease in pregnancy: fetal, neonatal and long-term outcomes
Publication date: Available online 15 February 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Emily Haesler, Nabil Melhem, Manish D. SinhaAbstractRenal disease in women of childbearing age is estimated to be around 3%, consequently renal disease is not an uncommon co-morbidity in pregnancy. There has been considerable evidence published over the last 20 years to suggest that renal disease in pregnancy is associated with higher maternal, fetal and offspring morbidity. Studies published are largely heterogeneous, include unmatched cohort studies and focus on early neonatal outcomes s...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - February 16, 2019 Category: OBGYN Source Type: research

Unveiling the Role of DNA Methylation in Kidney Transplantation: Novel Perspectives toward Biomarker Identification.
Abstract The burden of chronic kidney disease is dramatically rising, making it a major public health concern worldwide. Kidney transplantation is now the best treatment for patients with end-stage renal disease. Although kidney transplantation may improve survival and quality of life, its long-term results are hampered by immune- and/or non-immune-mediated complications. Thus, the identification of transplanted patients with a higher risk of posttransplant complications has become a big challenge for public health. However, current biomarkers of posttransplant complications have a poor predictive value, rising th...
Source: Biomed Res - February 16, 2019 Category: Research Authors: Agodi A, Barchitta M, Maugeri A, Basile G, Zamboni M, Bernardini G, Corona D, Veroux M Tags: Biomed Res Int Source Type: research

TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy in ischemic disease via PrPC
Publication date: Available online 16 February 2019Source: Redox BiologyAuthor(s): Yeo Min Yoon, SangMin Kim, Yong-Seok Han, Chul Won Yun, Jun Hee Lee, Hyunjin Noh, Sang Hun LeeAbstractAlthough autologous human mesenchymal stem cells (hMSCs) are a promising source for regenerative stem cell therapy in chronic kidney disease (CKD), the barriers associated with pathophysiological conditions limit therapeutic applicability to patients. We confirmed that level of cellular prion protein (PrPC) in serum was decreased and mitochondria function of CKD-derived hMSCs (CKD-hMSCs) was impaired in patients with CKD. We proved that trea...
Source: Redox Biology - February 16, 2019 Category: Biology Source Type: research

Serum fetuin-A is associated with the components of MIAC(malnutrition, inflammation, atherosclerosis, calcification) syndrome in different stages of chronic kidney disease
Authors: Mutluay R, Konca Değertekin C, Işıktaş Sayılar E, Derici Ü, Gültekin S, Gönen S, Arınsoy ST, Sindel MŞ Abstract Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). Materials and methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive pro...
Source: Turkish Journal of Medical Sciences - February 16, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

IJERPH, Vol. 16, Pages 566: Incidence and Risk Factors for Urinary Tract Infection in an Elder Home Care Population in Taiwan: A Retrospective Cohort Study
In conclusion, apart from the unmodifiable factors, avoiding prolonged urinary catheter placement, unnecessary prescriptions, and keeping good nutritional status may help to prevent UTI in home care patients. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - February 16, 2019 Category: Environmental Health Authors: Wei-Yi Shih Chia-Chen Chang Meng-Ting Tsou Hsin-Lung Chan Ying-Ju Chen Lee-Ching Hwang Tags: Article Source Type: research

Challenges and opportunities for nephrology in Western Europe
Forty million people in Western Europe have chronic kidney disease (CKD).1 The number of patients receiving renal replacement therapy (RRT) increased by 23% from 2006 to 2015.2,3 Males predominate on dialysis. The mean age of patients receiving dialysis is 61.3 years, and 19% are over 80 years.3 Hemodialysis and transplantation predominate, costing around €40,000 to €80,000 and €10,000 to €20,000 per patient per year, respectively.1 Overall, 2% of health expenditure is consumed by RRT for 0.1% of the population. (Source: Kidney International)
Source: Kidney International - February 16, 2019 Category: Urology & Nephrology Authors: Eric Rondeau, Valerie A. Luyckx, Hans-Joachim Anders, Kai-Uwe Eckardt, Sandrine Florquin, Hans-Peter Marti, Klaus Ølgaard, Paul Harden, members of the Western Europe Regional Board, International Society of Nephrology Tags: Policy Forum Source Type: research

Predictors of withdrawal from renal replacement therapy among patients with acute kidney injury requiring renal replacement therapy
ConclusionAmong patients with AKI requiring RRT, CKD, ventilator use, hypoalbuminemia, and high MAP were associated with RRT withdrawal. Furthermore, keeping a higher MAP at RRT initiation  can potentially lead to dependence on RRT. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - February 16, 2019 Category: Urology & Nephrology Source Type: research

Influence of dialysis therapies on oral health: a pilot study
Conclusion: HD presented a more adverse impact on oral health than PD, particularly periodontal disease and oral Candida colonization; however, this impact on oral health appears to be reduced or ameliorated when patients change from HD to PD therapy. (Source: Quintessence International)
Source: Quintessence International - February 15, 2019 Category: Dentistry Source Type: research

Amelioration of Uremic Toxin Indoxyl Sulfate-Induced Osteoblastic Calcification by SET Domain Containing Lysine Methyltransferase 7/9 Protein
Conclusions: Our data demonstrated that SET7/9 downregulation and autophagy activation may be the key mechanism of IS-induced VC in CKD.Nephron (Source: Nephron)
Source: Nephron - February 15, 2019 Category: Urology & Nephrology Source Type: research

Diabetes Management in Older Adults With Chronic Kidney Disease
AbstractPurpose of ReviewOlder adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management.Recent FindingsAlthough there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities. These individuals face an increased risk of cognitive impairment and dementia, frailty, dysglycemia, polypharmacy, declin...
Source: Current Diabetes Reports - February 15, 2019 Category: Endocrinology Source Type: research

Clinical and biochemical characteristics and the association of angiotensin type 1 receptor with normoalbuminuric chronic kidney disease among South Indian type 2 diabetes population
AbstractThe aim of the study was to determine the clinical and biochemical characteristics especially cystatin C and the association of angiotensin type I receptor (AT1R) gene polymorphism with normoalbuminuric chronic kidney disease (NACKD) among South Indian type 2 diabetes (T2DM) population.Material and methodsThe study comprised of 308 (M:F 190:118) subjects with T2DM categorized into three groups. Group I: T2DM patients without albuminuria (NA) and estimated glomerular filtration rate (eGFR)>  90 ml/min/1.73m2 (n = 110); group II: T2DM patients with albuminuric chronic kidney disease (CKD) with eGFR
Source: International Journal of Diabetes in Developing Countries - February 15, 2019 Category: Endocrinology Source Type: research

Monogenic causes of chronic kidney disease in adults
Approximately 500 monogenic causes of chronic kidney disease (CKD) have been identified, mainly in pediatric populations. The frequency of monogenic causes among adults with CKD has been less extensively studied. To determine the likelihood of detecting monogenic causes of CKD in adults presenting to nephrology services in Ireland, we conducted whole exome sequencing (WES) in a multi-centre cohort of 114 families including 138 affected individuals with CKD. Affected adults were recruited from 78 families with a positive family history, 16 families with extra-renal features, and 20 families with neither a family history nor...
Source: Kidney International - February 14, 2019 Category: Urology & Nephrology Authors: Dervla M. Connaughton, Claire Kennedy, Shirlee Shril, Nina Mann, Susan L. Murray, Patrick A. Williams, Eoin Conlon, Makiko Nakayama, Amelie T. van der Ven, Hadas Ityel, Franziska Kause, Caroline M. Kolvenbach, Rufeng Dai, Asaf Vivante, Daniela A. Braun, R Tags: Clinical Investigation Source Type: research

Emergence of Cheyne-Stokes Breathing after Hypoglossal Nerve Stimulator Implant in a Patient with Mixed Sleep Apnea
This is a case report of a man in his 60s with stage 3 chronic kidney disease, hypertension, hyperlipidemia, type 2 diabetes, bladder and kidney cancer, and depression who underwent hypoglossal nerve stimulator implantation and subsequently demonstrated a Cheyne-Stokes breathing pattern. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - February 14, 2019 Category: ENT & OMF Source Type: research

Prevalence and predictors of self care practices among hypertensive patients at Jimma University Specialized Hospital, Southwest Ethiopia: cross-sectional study
Hypertension is a major risk factor and precursor of myocardial infarction, chronic kidney disease, heart failure and premature death. These vascular events increased costs of hypertension management. Self-car... (Source: BMC Research Notes)
Source: BMC Research Notes - February 14, 2019 Category: Research Authors: Busha Gamachu Labata, Muktar Beshir Ahmed, Ginenus Fekadu Mekonen and Fekede Bekele Daba Tags: Research note Source Type: research

Reassessing the Safety Profile of Lesinurad in Combination with Xanthine Oxidase Inhibitor Therapy
We examined these risks for each treatment group and the risks stratified by estimated glomerular filtration rate (eGFR).ResultsOverall, the relative risk for sCri was>  1.0 with the 400 mg/day dose of lesinurad and higher with the 200 mg/day dose, but it was
Source: Rheumatology and Therapy - February 14, 2019 Category: Rheumatology Source Type: research

Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study
Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound sol... (Source: BMC Nephrology)
Source: BMC Nephrology - February 14, 2019 Category: Urology & Nephrology Authors: Wenji Wang, Guihua Hao, Yu Pan, Shuai Ma, Tianye Yang, Peng Shi, Qiuyu Zhu, Yingxin Xie, Shaojun Ma, Qi Zhang, Hong Ruan and Feng Ding Tags: Research article Source Type: research

Urinary Potassium Excretion and Progression of Chronic Kidney Disease.
CONCLUSIONS: Low urinary potassium excretion is associated with progression of CKD. PMID: 30765533 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 14, 2019 Category: Urology & Nephrology Authors: Kim HW, Park JT, Yoo TH, Lee J, Chung W, Lee KB, Chae DW, Ahn C, Kang SW, Choi KH, Han SH, KNOW-CKD Study Investigators Tags: Clin J Am Soc Nephrol Source Type: research