Recent advances in the identification and management of inherited hyperoxalurias
AbstractPrimary hyperoxaluria (PH) is caused by genetic mutations resulting in oxalate overproduction leading to nephrolithiasis, nephrocalcinosis, extrarenal manifestations, chronic kidney disease, and end-stage renal disease. Advances in genetic testing techniques have improved our ability to efficiently and effectively obtain a definitive diagnosis of PH as well as easily screen at-risk family members. Similarly, advances in technologies related to intervening at the genetic and molecular level promise to change the way we treat patients with PH. In this review, we provide an update regarding the identification of under...
Source: Urolithiasis - December 10, 2018 Category: Urology & Nephrology Source Type: research

The miRNA-184 drives renal fibrosis by targeting HIF1AN in vitro and in vivo
AbstractProgressive renal fibrosis is the last phase of chronic kidney disease and results in renal failure. Micro-RNA has been demonstrated as important agent to drive organ fibrosis. However, the precise mechanisms are not fully understood. Here, we found miRNA-184 as a critical mediator to promote the renal fibrosis by targeting HIF1AN. In Vivo, miRNA-184 expression levels remarkably increased both in patients ’ serum and in unilateral ureteral obstruction kidneys, as well as induced the expression of COL1A1 and COL3A1. Furthermore, transfection of NRK49F cells with miRNA-184 mimics down-regulated HIF1AN, transfec...
Source: International Urology and Nephrology - December 10, 2018 Category: Urology & Nephrology Source Type: research

Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice
In conclusion, chronic kidney dysfunction causes degradation of sulfatides in the liver to decrease serum sulfatide levels. One explanation of these results is that indoxyl sulfate, a uremic toxin, accelerates the degradation of sulfatides in liver tissue. (Source: Glycoconjugate Journal)
Source: Glycoconjugate Journal - December 10, 2018 Category: Biochemistry Source Type: research

Primary care provider perceptions of enablers and barriers to following guideline-recommended laboratory tests to confirm chronic kidney disease: a qualitative descriptive study
Patients should receive follow-up serum creatinine tests after an initial abnormal result to diagnose chronic kidney disease. However, half of the time this fails to occur in primary care. We interviewed prima... (Source: BMC Family Practice)
Source: BMC Family Practice - December 10, 2018 Category: Primary Care Authors: Danielle M. Nash, Amit X. Garg, K. Scott Brimble and Maureen Markle-Reid Tags: Research article Source Type: research

Leadership in the Industry Arena: Nephrologists in Nonclinical Leadership Roles
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Akhtar AshfaqOf late, fewer residents are choosing nephrology as a career. Contributing factors may include lack of prestige, uncertain potential of future income, and poor work-life balance. Some current nephrologists are considering transitioning to another career for similar reasons. For those who decide that practicing nephrology is no longer appealing, there are many available avenues where they can use their nephrology expertise and still have a successful future. A leadership role in the pharmaceutical industry is...
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Leading Integrated Kidney Care Entities of the Future
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Douglas S. Johnson, Klemens B. MeyerThe leaders of 20th century kidney failure treatment took chances; 21st century leaders of integrated kidney care must do the same. Some risks are clinical, some are organizational, and some are financial. Decent and constructive leadership entails humility. A working practitioner is a better leader. Effective leaders empower their employees and collaborators to lead and encourage them to work together. Integrated kidney care leadership supports exchange of ideas within and among organ...
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Women in Nephrology Leadership
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Wendy Weinstock Brown, Sharon AndersonWomen and men tend to take different paths to leadership, with men being more intentional. When women do undertake leadership activities, they tend to be surprised by how much they enjoy it. Women's leadership styles tend to be more collaborative and inclusive. Women are used to multitasking and tend to persist under difficult circumstances. The nephrology manpower crisis affects both men and women, although some of the drivers are different. There is a persistent and well-known pay ...
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Mentorship in Medicine and Nephrology: More Important Than Ever
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Belinda Jim, Jerry YeeMentorship has always been important in medicine. In fact, one can argue that that is how doctors are trained. Moreover, mentorship has been proven to preserve and elevate those who wish to pursue academic medicine. In nephrology, mentorship has become paramount, as interest in the field has declined during this decade. In this article, we will delineate how mentorship impacts physician careers, describe different types of mentors and their characteristics, and summarize responsibilities of mentors ...
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Nephrologist Leadership in Advocacy and Public Policy
This article explores the impact of nephrology leadership on government decision making and the important role of the nephrologist in advocacy and public policy at the Federal, state, and regional levels. (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Leading the Dialysis Unit: Role of the Medical Director
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Sharmeela Saha, Jay B. WishThe responsibilities of a dialysis unit medical director are specified in the ESRD Conditions for Coverage and encompass multiple quality, safety, and educational domains. Many of these responsibilities require leadership skills that are neither intuitive nor acquired as part of the medical director's training. An effective medical director is able to shape the culture of the dialysis facility such that patients and staff feel free to communicate their concerns regarding suboptimal processes wi...
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Leadership in a Private Nephrology Practice: Autonomy Is More Than a Dream!
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Nelson Kopyt, Ravindra BolluPrivate practice is entering an era of diminishing reimbursement and increasing overhead associated with federally mandated payment reforms resulting in a need to move from the traditional fee-for-service to a value-based model, changes that place financial and organizational strain on nephrology practices. In addition, the changing geopolitical scene is one of mergers and consolidation of health care networks, which in turn are developing their own insurance plans or partnering with commercia...
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Administrative Leadership: Nephrologists in Non-nephrology Leadership Roles
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Michael Gitman, Alessandro Bellucci, Steven FishbaneNephrologists, perhaps more than other physicians, are drawn to health-care leadership positions. In this article, we consider reasons that nephrologists are uniquely suited to serve in these roles. We briefly review key aspects of leadership principles and skills. Finally, we discuss routes to non-nephrology leadership for younger members of the profession. (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Leading a Dialysis Organization: Role and Responsibilities of the Chief Medical Officer (Nephrologist Leadership in a Dialysis Provider Organization)
This article reviews the roles, responsibilities, and opportunities of the position as established in a midsize nonprofit dialysis provider. (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Leadership as a Division Chief of Nephrology
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Eleanor LedererThe position of chief of a division of nephrology in an academic medical center is a hands-on job, offering the opportunity to influence the future of the field through the creation of unique clinical, research, and education programs. Today, most academic centers face significant financial challenges, thus the division chief must develop a variety of skills to accomplish his or her goals. Interactions and relationships with the leadership of the academic center, including the hospital executives, can faci...
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

A History of Leadership in Dialysis: Perspectives From Seasoned Leaders
This article includes Nephrology Oral History Project excerpts illustrating leadership contributions to dialysis machines, peritoneal dialysis catheters, and treatment best practices. In addition to individual contributions, improvements in treatment also come from patient and provider organizations leading the way and collectively advocating for change. Nephrology leaders continue to play a crucial role in improving dialysis outcomes and quality of life. (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Leadership in Nephrology: Vital to the Future of Our Profession
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Rebecca J. Schmidt (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Leadership as Tribal Leader
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

Masthead
Publication date: November 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 6Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - December 9, 2018 Category: Urology & Nephrology Source Type: research

The Spanish Society of Nephrology (SENEFRO) commentary to the Spain GBD 2016 report: Keeping chronic kidney disease out of sight of health authorities will only magnify the problem.
Authors: Ortiz A, Sanchez-Niño MD, Crespo-Barrio M, De-Sequera-Ortiz P, Fernández-Giráldez E, García-Maset R, Macía-Heras M, Pérez-Fontán M, Rodríguez-Portillo M, Salgueira-Lazo M, Sánchez-Álvarez E, Santamaría-Olmo R, Simal-Blanco F, Pino-Pino MD Abstract The Global Burden of Disease (GBD) study measures the health of populations worldwide and by country on an annual basis and aims at helping guide public policy on health issues. The GBD estimates for Spain in 2016 and recent trends in mortality and morbidity from 2006 to 2016 were recent...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - December 9, 2018 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Association between renal dysfunction and metalloproteinase (MMP)-9 activity in hypertensive patients.
Authors: Rodríguez-Sánchez E, Navarro-García JA, Aceves-Ripoll J, Álvarez-Llamas G, Segura J, Barderas MG, Ruilope LM, Ruiz-Hurtado G Abstract BACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMPs) are involved in deleterious tissue remodeling associated with target organ damage in renal disease. The aim of this study was to study the association between renal dysfunction and activity of the inflammatory metalloproteinase MMP-9 in hypertensive patients with mild-moderate chronic kidney disease (CKD). MATERIAL AND METHODS: Plasmatic active MMP-9, total MMP-9, tissue inhibitor of M...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - December 9, 2018 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Transjugular percutaneous endovascular treatment of dysfunctional hemodialysis access.
CONCLUSION:: For the treatment of dysfunctional or immature hemodialysis access, the transjugular approach is a feasible and effective option that avoids injury to the graft or draining vein, especially in immature fistulas. PMID: 30520334 [PubMed - as supplied by publisher] (Source: The Journal of Vascular Access)
Source: The Journal of Vascular Access - December 8, 2018 Category: Surgery Tags: J Vasc Access Source Type: research

Recirculating peritoneal dialysis system using urease-fixed silk fibroin membrane filter with spherical carbonaceous adsorbent
In this study, we designed the wearable artificial kidney (WAK) system for peritoneal dialysis (PD) using urease-immobilized silk fibroin (SF) membrane and polymer-based spherical carbonaceous adsorbent (PSCA). We evaluated this kit's removal abilities of uremic toxins such as urea, creatinine, uric acid, phosphorus, and β2-microglobulin from the dialysate of end-stage renal disease (ESRD) patients in vitro. The uremic toxins including urea, creatinine, uric acid, and phosphorus were removed about 99% by immobilized SF membrane and PSCA filter after 24 h treatment. However, only 50% of β2-microglobulin was remo...
Source: Materials Science and Engineering: C - December 8, 2018 Category: Materials Science Source Type: research

Identification of salivary peptidomic biomarkers in chronic kidney disease patients undergoing haemodialysis
Publication date: Available online 7 December 2018Source: Clinica Chimica ActaAuthor(s): Peiyuan Tong, Chao Yuan, Xiangyu Sun, Qi Yue, Xiaoling Wang, Shuguo ZhengAbstractBackgroundChronic kidney disease (CKD) is a worldwide public health problem. To detect discriminating salivary peptide profiles between CKD patients undergoing haemodialysis (HD) and healthy controls (HCs) and to screen candidate biomarkers for CKD, we preliminarily explored the diagnostic potentiality of saliva.MethodsSaliva samples from 30 CKD HD patients and 35 HCs were analysed using matrix-assisted laser desorption/ionization time-of-flight mass spect...
Source: Clinica Chimica Acta - December 8, 2018 Category: Laboratory Medicine Source Type: research

Analytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy
Hypertension and chronic kidney disease are inextricably linked. Hypertension is a well-recognized contributor to chronic kidney disease progression and, in turn, renal disease potentiates hypertension. A generalized approach to drug selection and dosage has not proven effective in managing these conditions, in part, because patients with heterogeneous kidney disease and hypertension etiologies are frequently grouped according to functional or severity classifications. Genetic testing may serve as an important tool in the armamentarium of clinicians who embrace precision medicine. Increasing scientific evidence has support...
Source: Pharmacogenetics and Genomics - December 8, 2018 Category: Genetics & Stem Cells Tags: SHORT COMMUNICATION Source Type: research

Renal Dysfunction among Ghanaians Living with Clinically Diagnosed Hypertension in the Asutifi-South District: A Cross-Sectional Descriptive Study at the St. Elizabeth Hospital, Hwidiem.
Conclusion: Renal dysfunction is common among people living with hypertension in the Asutifi-South District of the Brong Ahafo Region. Femininity, older age, disease comorbidity with diabetes, Thiazide diuretic and AR Blocker usage, and increasing duration of medication accounted for higher kidney dysfunction. Regular screening and management are therefore recommended to avert progression to end-stage renal failure (ESRD). PMID: 30519488 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - December 8, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Analysis of prognostic factors affecting poor outcomes in 41 cases of Fournier gangrene.
Conclusion: Fournier gangrene with extensive soft tissue necrosis and pre-existing chronic kidney disease was associated with poor prognosis and complexity of patient management. Early recognition of dissemination and premorbid renal function is essential to reduce mortality and establish a management plan for this disease. PMID: 30505824 [PubMed] (Source: Annals of Surgical Treatment and Research)
Source: Annals of Surgical Treatment and Research - December 7, 2018 Category: Surgery Tags: Ann Surg Treat Res Source Type: research

Left Ventricular Strain and Relaxation Are Independently Associated with Renal Cortical Perfusion in Hypertensive Patients.
The objective of the study was to assess the influence of cardiac function, including left ventricular contractility and relaxation, on renal cortical perfusion in patients with hypertension and chronic kidney disease treated pharmacologically. There were 63 patients (7 F and 56 M; aged 56 ± 14) with hypertension and stable chronic kidney disease enrolled into the study. Serum cystatin C, with estimated glomerular filtration rate (eGFR), ambulatory blood pressure monitoring, carotid intima-media thickness (cIMT), echocardiography with speckle tracking imaging and the calculation of global longitu...
Source: Advances in Experimental Medicine and Biology - December 7, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

The current state of sickle cell trait: implications for reproductive and genetic counseling.
Authors: Pecker LH, Naik RP Abstract Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because of this high frequency, reproductive counseling is of paramount importance. In addition, unlike other carrier states, SCT seems to be a risk factor for several clinical complications, such as extreme exertional injury, chronic kidney disease, and venous thromboembol...
Source: Hematology ASH Education Program - December 7, 2018 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Platelet reactivity in patients with chronic kidney disease undergoing percutaneous coronary intervention.
This study aimed to evaluate the platelet reactivity in real-world patients with different chronic kidney disease (CKD) stages after percutaneous coronary intervention (PCI), and to examine whether high residual platelet reactivity (HRPR) is associated with higher incidence of adverse cardiovascular events in a 2-year follow up. A total of 10 724 consecutive patients receiving DAPT with aspirin and clopidogrel after PCI throughout 2013 were enrolled. We applied modified thromboelastography (mTEG) in 6745 patients. Kaplan-Meier analysis and Cox proportional regression analysis were applied to illustrate end points for patie...
Source: Platelets - December 7, 2018 Category: Hematology Tags: Platelets Source Type: research

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.
Authors: Hamed SA Abstract INTRODUCTION: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Areas covered: This review summarized central and peripheral nervous system complications of uremic syndrome of CKD and their pathogenic mechanisms. They include cognitive deterioration, encephalopathy, seizures, asterixis, myoclonus, restless leg syndrome, central pontine mye...
Source: Expert Review of Clinical Pharmacology - December 7, 2018 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

Blood kidney injury Molecule-1 predicts short and longer-term kidney outcomes in patients undergoing diagnostic coronary and/or peripheral angiography- results from the catheter sampled blood archive in cardiovascular diseases (CASABLANCA) study
Publication date: Available online 7 December 2018Source: American Heart JournalAuthor(s): Nasrien E. Ibrahim, Cian P. McCarthy, Shreya Shrestha, Asya Lyass, Yiwei Li, Hanna K. Gaggin, Mandy L. Simon, Joseph M. Massaro, Ralph B. D'Agostino, Joseph M. Garasic, Roland RJ van Kimmenade, James L. JanuzziAbstractBackgroundKidney injury is common in patients with cardiovascular disease.ObjectivesWe determined whether blood measurement of kidney injury molecule-1 (KIM-1), would predict kidney outcomes in patients undergoing angiographic procedures for various indications.Methods1208 patients undergoing coronary and/or peripheral ...
Source: American Heart Journal - December 7, 2018 Category: Cardiology Source Type: research

[Mortality from chronic kidney disease in Peru: national trends 2003-2015].
Authors: Carrillo-Larco RM, Bernabé-Ortiz A Abstract OBJECTIVES.: To describe the mortality trend due to chronic kidney disease (CKD) in Peru in the period 2003-2015. MATERIALS AND METHODS.: Analysis of secondary data and ecological design. National mortality registries based on death certificates were analyzed. ERC was defined as CIE code 10: N18 in the basic cause. Absolute and relative frequencies of death by ERC are described. To estimate the proportion of deaths by CKD in each region of Peru, a generalized mixed linear model was used. The outcome variable was the proportion of deaths, the independen...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - December 7, 2018 Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research

[Invasive Fusariosis: Report of Three Cases in Peru].
We present three cases that show three different clinical forms of Fusarium spp. disease that affected different types of patients (patients with hematological malignancy, chronic kidney disease in peritoneal dialysis and post-surgical for osteoarticular pathology), each with its own characteristics that merit discussion. These cases show different clinical forms of invasive fusariosis caused by Fusarium solani complex species in patients with different pathologies and therapeutic management that could be risk factors for the development of the disease. The clinical recognition of fusariosis, not only in oncohematological ...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - December 7, 2018 Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research

Serum level vitamin D and parathyroid hormone, and mortality, with or without chronic kidney disease
AbstractLevels of vitamin D and parathyroid hormone (PTH) are closely associated with renal function. We evaluated the associations among 25-hydroxyvitamin D (25OHD) levels, PTH levels, and mortality, and whether these associations varied by renal function. We used data from the Dong-gu Study, a population-based cohort in Korean adults. We analyzed the associations among intact PTH, 25OHD levels and mortality in 8580 participants. Hazard ratios (HRs) for mortality were calculated using Cox proportional hazards regression after adjusting for age, sex, month of sampling, lifestyle, and comorbidities. We also evaluated the ef...
Source: Journal of Bone and Mineral Metabolism - December 7, 2018 Category: Orthopaedics Source Type: research

Body Mass Index, waist circumference, and health-related quality of life in adults with chronic kidney disease
ConclusionsIn adults with CKD, WC is a better indicator of poor physical HRQOL than BMI. The association between WC and physical HRQOL is modified by age, sex, eGFR, and comorbidities such as diabetes and cardiovascular disease. (Source: Quality of Life Research)
Source: Quality of Life Research - December 7, 2018 Category: Health Management Source Type: research

New Markers of Cell Migration and Inflammation in Children with Chronic Kidney Disease.
CONCLUSIONS: Systemic inflammation and cell migration are triggered by CKD and additionally aggravated by chronic dialysis, with more evident negative impact of HD than APD. Discrepancies in MCP1, MCSF and neopterin serum concentrations suggest they may serve as new markers of cellular and inflammatory responses in children with CKD. PMID: 30516070 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 6, 2018 Category: Research Tags: Biomarkers Source Type: research

Chronic Kidney Disease Severity Is Associated With Selective Expansion of a Distinctive Intermediate Monocyte Subpopulation
Serika D. Naicker, Sarah Cormican, Tom ás P. Griffin, Silvia Maretto, William P. Martin, John P. Ferguson, Deirdre Cotter, Eanna P. Connaughton, M. Conall Dennedy, Matthew D. Griffin (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 6, 2018 Category: Allergy & Immunology Source Type: research

Nocturnal blood pressure decrease in patients with chronic kidney disease and in healthy controls - significance of obstructive sleep apnea and renal function.
Authors: Hornstrup BG, Gjoerup PH, Wessels J, Lauridsen TG, Pedersen EB, Bech JN Abstract Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-match...
Source: International Journal of Nephrology and Renovascular Disease - December 6, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Association between breast arterial calcifications found on mammography and coronary artery calcifications in asymptomatic Saudi women
BACKGROUND:Currently, there are no data on the prevalence of breast arterial calcification (BAC) in Saudi women. Furthermore, there are no data on the relationship between BAC and coronary artery calcium score (CACS) as a coronary artery disease (CAD) risk factor in Saudi women who undergo mammography.  OBJECTIVE: Examine the role of BAC as a potential female-specific risk factor for CAD in Saudi women in order to investigate the relationship between BAC and CACS in women who undergo a screening mammography, and study the relationship between BAC and CAD risk factors, including age, diabetes mellitus, hypertensio...
Source: Annals of Saudi Medicine - December 6, 2018 Category: General Medicine Tags: ISSUE 6 Source Type: research

Designing and Implementing an ANFIS Based Medical Decision Support System to Predict Chronic Kidney Disease Progression
Ali Yadollahpour, Jamshid Nourozi, Seyed Ahmad Mirbagheri, Eric Simancas-Acevedo, Francisco R. Trejo-Macotela (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - December 6, 2018 Category: Physiology Source Type: research

Chronic kidney disease in low-middle income populations: a call to action for screening and prevention
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - December 6, 2018 Category: Emergency Medicine Source Type: research

Discrepancy Between Equations Estimating Kidney Function in Geriatric Care: A Study of Implications for Drug Prescription
ConclusionIn acute geriatric care units, recommended drug dose adjustments are frequently discordant according to the equations used to estimate kidney function, notably for benzodiazepines, anticoagulants, and anti-microbial drugs. The consequences for treatment efficacy and safety should be investigated. (Source: Drugs and Aging)
Source: Drugs and Aging - December 6, 2018 Category: Geriatrics Source Type: research

Single-brand dual-chamber discriminators to prevent inappropriate shocks in patients implanted with prophylactic implantable cardioverter defibrillators: a propensity-weighted comparison of single- and dual-chamber devices
AbstractPurposeComparisons of the efficacy of dual- vs. single-chamber implantable cardioverter defibrillators (ICDs) in preventing inappropriate shocks have had contradictory results. We investigated whether dual-chamber devices have a lower risk of inappropriate shocks and the specific role of supraventricular tachycardia (SVT) discriminators.MethodsAll heart failure (HF) patients without an indication for pacing and implanted with a prophylactic ICD were recruited from the nationwide multicenter UMBRELLA registry. Arrhythmic events were collected by remote monitoring and reviewed by a committee of experts.ResultsAmong 7...
Source: Journal of Interventional Cardiac Electrophysiology - December 6, 2018 Category: Cardiology Source Type: research

Efficacy and safety of once-monthly risedronate in osteoporosis subjects with mild-to-moderate chronic kidney disease: a post hoc subgroup analysis of a phase III trial in Japan
AbstractLimited data are available on the safety and efficacy of anti-resorptive agents, particularly once-monthly bisphosphonates, for use in osteoporotic patients with chronic kidney disease (CKD). We conducted a post hoc analysis of data from a 12-month, randomized, double-blind, phase III study to evaluate the safety and efficacy of once-monthly risedronate (RIS-OM) 75  mg tablets in Japanese osteoporosis patients with mild-to-moderate CKD. Patients who received RIS-OM 75 mg were stratified by baseline estimated glomerular filtration rate (eGFR; ≥ 90, ≥ 60 to 
Source: Journal of Bone and Mineral Metabolism - December 6, 2018 Category: Orthopaedics Source Type: research

End-Stage Kidney Patients Require Hemodialysis Therapy Full Start
Recently the concept that prescription of chronic hemodialysis (HD) start should be tailored based on residual renal function (RRF) and urine output (UO) has been revived from the past and called infrequent or incremental dialysis. It mainly consists in prescribing 1 or 2 HD sessions per week instead of what has become the standard thrice-weekly HD. It is both surprising and fascinating that almost 60 years after the first end-stage kidney disease patient was treated by Scribner et al. [Trans Am Soc Artif Intern Organs 1960; 6: 114 –122], the nephrology community still questions the best way to start HD therapy. This...
Source: Blood Purification - December 5, 2018 Category: Hematology Source Type: research

Sickle Cell Nephropathy in the Pediatric Population
Background: Compared to the past, patients with sickle cell disease (SCD) currently live longer due to improvements in diagnosis and comprehensive care. Due to these advances, long-term chronic complications pose a greater challenge in the management of patients with SCD. In particular, sickle cell nephropathy (SCN) is associated with significant morbidity and mortality across all age groups. Furthermore, SCN is an understudied condition with relatively few symptoms and therefore requires close surveillance. In this review, we sought to explore the epidemiology, natural history, and treatment options for SCN with an emphas...
Source: Blood Purification - December 5, 2018 Category: Hematology Source Type: research

Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using UPLC-MS/MS
Publication date: Available online 4 December 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chia-Ni Lin, I-Wen Wu, Yun-Fen Huang, Shu-Yu Peng, Ya-Ching Huang, Hsiao-Chen NingAbstractChronic kidney disease (CKD) is a complex disorder that affects multiple organs and increases the risk of cardiovascular complications. CKD affects approximately 12% of the population in Taiwan. Loss of kidney function leads to accumulation of potentially toxic compounds such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS), two protein-bound uremic solutes that can stimulate the progression of CKD. The aim of this study was to asse...
Source: Journal of Food and Drug Analysis - December 5, 2018 Category: Food Science Source Type: research

The effect of chronic kidney disease on lipid metabolism
AbstractThe major cause of death among chronic kidney disease patients is cardiovascular diseases. Cardiovascular and kidney disease are interrelated and increase the severity of each other. Dyslipidemia is one the major causes of cardiovascular disease among chronic kidney disease patients along with diabetes and hypertension. The relationship between dyslipidemia and chronic kidney disease is reciprocal. Dyslipidemia is known to be a risk factor for chronic kidney disease and chronic kidney disease causes major alterations on lipoprotein profile, defined as the “dyslipidemic profile” of chronic kidney disease...
Source: International Urology and Nephrology - December 5, 2018 Category: Urology & Nephrology Source Type: research