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The Tolerability and Safety Profile of Patiromer: A Novel Polymer-Based Potassium Binder for the Treatment of Hyperkalemia.
Authors: Pitt B, Garza D Abstract INTRODUCTION: Hyperkalemia (HK) occurs often among patients with chronic kidney disease (CKD) and heart failure (HF) and those treated with renin-angiotensin-aldosterone system inhibitors (RAASI). Even small deviations from normal potassium levels carry increased risk of mortality. Patiromer is approved for treatment of HK and has been shown in clinical trials to reduce serum potassium among patients with HK and comorbid conditions. Areas covered: We review pooled data from two clinical trials of patiromer in patients with CKD and HK, safety of patiromer in special populations, dru...
Source: Expert Opinion on Drug Safety - April 19, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Initial Management of Colonic Diverticular Bleeding: Observational Study
Conclusions: Contrast-enhanced CT upon arrival is suggested, and patients with extravasation on CT would be good candidates for urgent colonoscopy, as well as patients who have a history of CDB and CKD.Digestion 2018;98:41 –47 (Source: Digestion)
Source: Digestion - April 19, 2018 Category: Gastroenterology Source Type: research

583 Psychometric validation and meaningful change threshold of the worst itching intensity numerical rating scale for use in hemodialysis patients with pruritus
Pruritus associated with chronic kidney disease is a distressing condition which has not been rigorously studied using validated patient-reported outcome (PRO) tools. The purpose of this study was to conduct psychometric validation of the Worst Itching Intensity Numeric Rating Scale (NRS), a single item PRO measuring the worst itching severity in the past 24 h on a 0-10-point scale, and to determine the threshold for a clinically meaningful change for this patient population. This analysis was based on data from a phase II randomized, placebo-controlled study which demonstrated the effectiveness of CR845 at reducing modera...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: C. Munera, M.K. Vernon, J.W. Stauffer, R.H. Spencer, F. Menzaghi Tags: Clinical Research: Patient Outcomes Research Source Type: research

582 Measurement of pruritus associated with chronic kidney disease: A qualitative study of two patient-reported outcome instruments
Chronic kidney disease-associated pruritus (CKD-aP) is a debilitating chronic itching condition frequently reported in end stage renal disease patients, with no approved treatments in the United States (US). As the sensation of itching can only be assessed by patient report, reliable, valid and sensitive patient-reported outcomes (PROs) are required to demonstrate treatment benefits in studies of therapies under development for treatment of pruritus in hemodialysis (HD) patients. The purpose of this study was to conduct qualitative interviews in HD patients to evaluate the content validity of two existing PRO instruments, ...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: F. Menzaghi, M.K. Vernon, M. Mattera, J.W. Stauffer, R.H. Spencer, C. Munera Tags: Clinical Research: Patient Outcomes Research Source Type: research

1089 Antipruritic effect of the novel kappa opioid receptor agonist CR845
Patients with chronic kidney disease are commonly afflicted by pruritus, a condition with no treatment approved in the USA. The etiology of this condition is likely multifactorial, including systemic inflammation and deficiency in the endogenous kappa opioid system. CR845 is a novel and full kappa opioid receptor agonist with no off-target activities, including mu- or delta-opioid receptors. In addition to its unique receptor profile, the peptidic structure of CR845 restricts its entry into the central nervous system. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: R.H. Spencer, C. Munera, J.W. Stauffer, F. Menzaghi Tags: Pharmacology and Drug Development Source Type: research

In this issue
Patients with rheumatoid arthritis have a higher prevalence of chronic kidney disease than the general population. This is attributed to nephrotoxic drugs and systemic inflammation. Biologic agents have revolutionized the treatment of rheumatoid arthritis. Sumida and colleagues retrospectively examined a large rheumatoid arthritis cohort to determine whether treatment with biologics has improved kidney outcomes. Using propensity matched patients, the incidence of chronic kidney disease and change in estimated glomerular filtration rate was compared in 4000 patients treated with a biologic agent to 4000 patients who were no...
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Tags: In This Issue Source Type: research

The Authors Reply
We thank Fusaro and her colleagues for their comments.1 We concur that there is a sound need for large, well-designed clinical studies to assess the prevalence, risk factors, treatment, and outcome of vertebral fractures in patients with chronic kidney disease (CKD). In our review,2 we did not include quantitative vertebral morphology as assessed by MorphoXpress software to quantify vertebral fractures in CKD. The assessment of vertebral fractures by quantitative vertebral morphology in patients on dialysis and renal transplant recipients resulted in the validation of the tool in osteoporotic patients of the general popula...
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Authors: Pablo Antonio Ure ña-Torres, Martine Cohen-Solal Tags: Letter to the Editor Source Type: research

Clinical relevance and future perspective of fractures in  patients with chronic kidney disease
We read with great interest the article by Pimentel et  al.1 on diagnosis, treatment, and prevention of fractures in patients with chronic kidney disease (CKD). We support the message of the clinical relevance of fracture events in CKD, and we would like to add further comments on the issue, such as to stress the need to better study the likely underes timated prevalence of vertebral fractures in CKD. To do so, a systematic population-based screening with spine plain films and morphometric studies of vertebral deformity2 is needed. (Source: Kidney International)
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Authors: Maria Fusaro, Jorge B. Cannata-And ía, Thomas L. Nickolas, Mario Plebani, Maria Cristina Mereu, Andrea Aghi, Maurizio Gallieni Tags: Letter to the Editor Source Type: research

Age-adjusted global glomerulosclerosis in addition to Oxford histological classification of IgA nephropathy
We thank Hommos et  al. for their robust study that found that only globally sclerotic glomeruli (GSG) exceeding the age-specific 95th percentile for global glomerulosclerosis in healthy adults was associated with progressive chronic kidney disease in glomerulopathies presenting with nephrotic syndrome.1 Earlier, we demonstrated that extent of GSG was independently associated with end-stage renal disease at 30 years in a young cohort (median age, 25 years; interquartile range, 21–30 years) that did not receive immunosuppressants when diagnosed with IgA nephropathy (IgAN) in the 1970s and early 1980s. (Source: Kidney International)
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Authors: Cynthia C. Lim, Jason C.J. Choo, Choong Meng Chan, Keng Thye Woo Tags: Letter to the Editor Source Type: research

Global glomerulosclerosis in primary nephrotic syndrome: including age as a variable to predict renal outcomes
With normal aging, there are increased numbers of globally sclerotic glomeruli. Global glomerulosclerosis is also a feature of chronic kidney disease. In this issue, Hommos and colleagues provide data on the fraction of globally sclerotic glomeruli in healthy kidney donor biopsies. This provides reference for evaluation of whether isolated global glomerulosclerosis is evidence of pathology. (Source: Kidney International)
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Authors: Jeffrey B. Kopp Tags: Commentary Source Type: research

The Authors Reply
We thank Dr. Labriola and Dr. Jadoul for their comments.1 We fully agree with the relevance of falls as a major risk factor of fracture in such patients.2 Falls were mentioned and included in Figure  12 as an important determinant of fractures. However, this issue was not extensively discussed because of few relevant data available in chronic kidney disease (CKD) patients. CKD patients, including those treated by dialysis, may have a high propensity for falls. Several factors are probably invo lved, including accelerated aging with deleterious consequences such as impaired cognitive function, neurological disorders, v...
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Authors: Martine Cohen-Solal, Pablo Antonio Ure ña-Torres Tags: Letter to the Editor Source Type: research

Fractures in CKD patients: action plans should not overlook the prevention of falls!
In their recent review concerning the diagnosis, treatment, and prevention of fractures in chronic kidney disease (CKD) patients, Pimentel et  al.1 point out that the incidence of fractures increases according to CKD stage, with the highest relative risk in patients receiving chronic hemodialysis. The authors underline the high mortality and costs related to fractures in CKD patients and review clinical, biochemical, histological, and st ructural parameters related to bone fragility in CKD. The authors briefly mention but regrettably omit to discuss the occurrence of falls as a crucial determinant for fractures in hem...
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Authors: Laura Labriola, Michel Jadoul Tags: Letter to the Editor Source Type: research

Tumoral masses in failed kidneys
A 44-year-old male patient presented with recurrent urinary tract infections (urine cultures negative) for 2 years. He was diagnosed as having a urethral stricture, and he underwent dilatations. However, his renal functions deteriorated, and he developed chronic kidney disease (CKD) requiring dialysis and transplantation. Pretransplant workup revealed 4 –5 leukocytes on urine examination, proteinuria (0.2 g/d), and a serum creatinine level of 6.7 mg/dl. Magnetic resonance imaging of his kidneys showed multifocal hyperintense lesions in both. (Source: Kidney International)
Source: Kidney International - April 19, 2018 Category: Urology & Nephrology Authors: Ritambhra Nada, Raja Ramachandran, Ashwani Kumar, K.L. Gupta, Ashish Sharma Tags: Nephrology Image Source Type: research

TAK1 mediates apoptosis via p38 involve in ischemia-induced renal fibrosis.
Authors: Zhou J, Zhong J, Huang Z, Liao M, Lin S, Chen J, Chen H Abstract Renal fibrosis is a common and characteristic symptom of chronic kidney disease (CKD). However, the molecular mechanisms of renal fibrosis remain elusive. Ischemia injury, as a major cause of AKI, deserves more attention in order to improve the knowledge of AKI-induced fibrosis. Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) interacts directly with TGF-β, which play a critical role in the progression of fibrosis. Therefore, the present study aimed to investigate the role of TAK1 in the pathogenesis of ischemia-i...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 18, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Haemodialysis at home: review of current dialysis machines.
Authors: Haroon S, Davenport A Abstract INTRODUCTION: Only a minority of patients with chronic kidney disease treated by hemodialysis are currently treated at home. Until relatively recently, the only type of hemodialysis machine available for these patients was a slightly smaller version of the standard machines used for in-center dialysis treatments. Areas covered: There are now an alternative generation of dialysis machines specifically designed for home hemodialysis. The home dialysis patient wants a smaller machine, which is intuitive to use, easy to trouble shoot, robust and reliable, quick to set-up and put ...
Source: Expert Review of Medical Devices - April 18, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Chronic kidney disease in persons living with HIV: A systematic review
The purpose of our systematic review of research on chronic kidney disease (CKD) in persons living with HIV (PLWH) was to (a) compare and contrast diagnostic criteria for CKD, (b) identify risk factors of CKD in PLWH, and (c) elucidate the prevalence of CKD in PLWH. Keyword searches of PubMed and PsycInfo databases were followed by manual searches of references from 2000 through 2016; 21 studies met inclusion criteria. Sample sizes ranged from 8 to 15,140 with a mean age of 50 years, and represented diverse ethnicities/races and countries of origin. (Source: Journal of the Association of Nurses in AIDS Care)
Source: Journal of the Association of Nurses in AIDS Care - April 18, 2018 Category: Nursing Authors: Jungmin Park, Julie Ann Zuniga Source Type: research

Vertebral Bone Mineral Density Measured by Quantitative Computed Tomography With and Without a Calibration Phantom: A Comparison Between 2 Different Software Solutions
Quantitative computed tomography (CT) can be used to quantify bone mineral density (BMD) in the spine from clinical CT scans. We aimed to determine agreement and precision of BMD measurements by 2 different methods: phantom-less internal tissue calibration and asynchronous phantom-based calibration in a cohort of patients with chronic kidney disease (CKD). Patients with CKD were recruited for CT angiography of the chest, abdomen, and pelvis. BMD was analyzed by 2 different software solutions using different calibration techniques; phantom-based by QCT Pro (Mindways Inc.) and phantom-less by Extended Brilliance Workspace (P...
Source: Journal of Clinical Densitometry - April 18, 2018 Category: Radiology Authors: Josephine Therkildsen, Jesper Thygesen, Simon Winther, My Svensson, Ellen-Margrethe Hauge, Morten B öttcher, Per Ivarsen, Hanne Skou Jørgensen Tags: Original Article Source Type: research

Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti ‐HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients
American Journal of Transplantation, EarlyView. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - April 17, 2018 Category: Transplant Surgery Authors: Tomas Lorant , Mats Bengtsson , Torsten Eich , Britt ‐Marie Eriksson , Lena Winstedt , Sofia Järnum , Yvonne Stenberg , Anna‐Karin Robertson , Kristina Mosén , Lars Björck , Lars Bäckman , Erik Larss Source Type: research

Correlation of serum levels of fibroblast growth factor 23 and Klotho protein levels with bone mineral density in maintenance hemodialysis patients
AbstractObjectiveThe correlation of serum fibroblast growth factor 23 (FGF-23) and Klotho protein levels with bone mineral density (BMD) in maintenance hemodialysis (MHD) patients was analyzed.MethodsBetween January 2015 and November 2015, 125 MHD patients in our hospital were enrolled. Dual-energy X-ray absorptiometry was used to examine the BMD in the femoral neck and lumbar spine of MHD patients. The patients were divided into three groups: a normal bone mass group, an osteopenia group, and an osteoporosis group. An ELISA was performed to measure serum FGF-23, Klotho protein, and 1,25(OH)2VitD3 levels. Other parameters,...
Source: European Journal of Medical Research - April 17, 2018 Category: Research Source Type: research

Overweight is related to faster decline in annual glomerular filtration rate in kidney transplant
Few studies have examined the relationship between non-immunological factors and glomerular filtration rate (GFR) decline in kidney transplant. Correction of these factors in native kidneys slows progression of chronic kidney disease. The aim of this study was to analyze the association between control of non-immunological factors and annual decline of GFR. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - April 17, 2018 Category: Transplant Surgery Authors: Mariana Seija, Marcelo Nin, Jos é Santiago, Lizeth Apaza, Andrea Castaño, Luciana Poggi, Ines Urioste, Alessandra Chiossoni, Agustina Fernandez, Natalia Navarrine, Mariela Garau, Rossana Astesiano, María Soledad Ferrari, Oscar Noboa Source Type: research

Development of a Screening Tool to Predict Chronic Kidney Disease Risk in Post-nephrectomy Living Kidney Donors
Few studies have examined the long-term risks of kidney removal to donors despite the increase of frequency in kidney transplantation. This is the 1st study to develop prediction models of chronic kidney disease (CKD) for the 1-year period after donor nephrectomy in living donors. A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016, at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR)   (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - April 17, 2018 Category: Transplant Surgery Authors: J.S. Park, H.K. Ahn, J. Na, H.H. Lee, Y.E. Yoon, M.G. Yoon, W.K. Han Source Type: research

Effects of statin therapy on chronic kidney disease patients with coronary artery disease
Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 17, 2018 Category: Lipidology Authors: Hao Shen, Xiaodong Chen, Jingfen Lu, Honglin Yang, Yan Xu, Ao Zhu, Xiao Zhang, Fulong Ye and Yongchun Gu Tags: Research Source Type: research

Assessing known chronic kidney disease associated genetic variants in Saudi Arabian populations
Genome wide association studies of patients with European descent have identified common variants associated with risk of reduced estimated glomerular filtration rate (eGFR). A panel of eight variants were sel... (Source: BMC Nephrology)
Source: BMC Nephrology - April 17, 2018 Category: Urology & Nephrology Authors: Cyril Cyrus, Samir Al-Mueilo, Chittibabu Vatte, Shahanas Chathoth, Yun R. Li, Hatem Qutub, Rudaynah Al Ali, Fahad Al-Muhanna, Matthew B. Lanktree, Khaled Riyad Alkharsah, Abdullah Al-Rubaish, Brian Kim-Mozeleski, Brendan Keating and Amein Al Ali Tags: Research article Source Type: research

Evaluation of quantitative and qualitative renal outcome following nephron sparing surgery
Conclusion: Renal parenchymal loss and duration of ischemia have impact on the follow-up renal function. (Source: Journal of Clinical Imaging Science)
Source: Journal of Clinical Imaging Science - April 16, 2018 Category: Radiology Authors: Gautam Ram Choudhary Arup Kumar Mandal Uttam Mete Ravimohan Mavuduru Anish Bhatacharia Anupam Lal Suresh Goyal Source Type: research

Whole-body iron transport and metabolism: Mechanistic, multi-scale model to improve treatment of anemia in chronic kidney disease
by Joydeep Sarkar, Alka A. Potdar, Gerald M. Saidel Iron plays vital roles in the human body including enzymatic processes, oxygen-transport via hemoglobin and immune response. Iron metabolism is characterized by ~95% recycling and minor replenishment through diet. Anemia of chronic kidney disease (CKD) is characterized by a lack of synthesis of er ythropoietin leading to reduced red blood cell (RBC) formation and aberrant iron recycling. Treatment of CKD anemia aims to normalize RBC count and serum hemoglobin. Clinically, the various fluxes of iron transport and accumulation are not measured so that changes during diseas...
Source: PLoS Computational Biology - April 16, 2018 Category: Biology Authors: Joydeep Sarkar Source Type: research

Antimalarial Drugs for the Prevention of Chronic Kidney Disease in Patients with Rheumatoid Arthritis: The Importance of Controlling Chronic Inflammation?
PMID: 29661771 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 16, 2018 Category: Urology & Nephrology Authors: Rodrigues JC, Bargman JM Tags: Clin J Am Soc Nephrol Source Type: research

Effects of oral vitamin D3 supplementation in stage 3 chronic kidney disease subjects: insulin resistance syndrome and hormonal disturb interactions.
This study shows that continuous low doses (30.000 IU every month) are recommended for intermittent high doses (200.000 IU every 3 months) vitamin D supplementation. Our study suggests that the serum 25OHD profile can be considered a reliable biomarker in the bioclinic CKD status to stage stabilization and inhibit its evolution. PMID: 29661746 [PubMed - as supplied by publisher] (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - April 16, 2018 Category: Biochemistry Authors: Tahar A, Zerdoumi F, Saidani M, Griene L, Koceir EA Tags: Ann Biol Clin (Paris) Source Type: research

Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom
(Source: Clinical Epidemiology)
Source: Clinical Epidemiology - April 15, 2018 Category: Epidemiology Tags: Clinical Epidemiology Source Type: research

Association between the age-related decline in renal function and lumbar spine bone mineral density in healthy Chinese postmenopausal women
Objectives: The relationship between the decline of renal function and bone mineral density (BMD) in healthy populations is not well-researched. The aim of this study was to investigate the association between the age-related decline in renal function and lumbar spine BMD (LBMD) in a community-based cross-sectional study of 390 healthy postmenopausal women (mean age 62.97 ± 8.79 years) from Shenyang, China. Methods: Dual-energy x-ray absorptiometry was used to measure LBMD. Estimated glomerular filtration rate (eGFR) was calculated using a modified Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)...
Source: Menopause - April 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Elevated extracellular nucleosomes and their relevance to inflammation in stage 5 chronic kidney disease.
Authors: Phan T, McMillan R, Skiadopoulos L, Walborn A, Hoppensteadt D, Fareed J, Bansal V Abstract BACKGROUND: Chronic kidney disease is a disorder characterized by a pro-inflammatory state that is associated with increased morbidity and mortality. Endogenous damage- associated molecular patterns, including nucleosomes, may contribute to this persistent inflammation. The aim of this study was to profile and evaluate the clinical significance of circulating nucleosomes in patients with Stage 5 chronic kidney disease (CKD5) on hemodialysis (HD). METHODS: Under institutional review board approval, plasma samples ...
Source: International Angiology - April 14, 2018 Category: Cardiology Tags: Int Angiol Source Type: research

Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats.
Abstract Ursolic acid (UA), an ursane-type pentacyclic triterpenoid commonly found in apple peels and holy basil has been shown to possess many beneficial effects. Renal fibrosis is a complication of kidney injury and associated with increased risk of morbidity and mortality. In our previous investigation, a lupane-type pentacyclic triterpenoid, betulinic acid (BA) was found to have protective effect on chronic kidney disease (CKD) and renal fibrosis. This prompted us to explore the therapeutic value of UA, a chemically related compound to BA in CKD. CKD was induced by feeding adenine with the feed at a concentrat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2018 Category: Drugs & Pharmacology Authors: Thakur R, Sharma A, Lingaraju MC, Begum J, Kumar D, Mathesh K, Kumar P, Singh TU, Kumar D Tags: Biomed Pharmacother Source Type: research

Copeptin Plasma Levels are Associated With Decline of Renal Function in Patients With Type 2 Diabetes Mellitus
Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 14, 2018 Category: Research Authors: Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel G ómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F. Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar Tags: Original Article Source Type: research

Renal cell carcinoma for the nephrologist
Renal cell carcinoma (RCC), a malignancy whose incidence is increasing, is frequently encountered in general nephrology practice when acute and chronic kidney disease occurs in the course of disease. Importantly, when kidney disease develops in the setting of RCC, mortality is significantly increased with patients often dying of a non-cancer-related complication of kidney disease. As such, practicing nephrologists need to have a working knowledge of this cancer ’s biology, treatment, and complications. (Source: Kidney International)
Source: Kidney International - April 14, 2018 Category: Urology & Nephrology Authors: Mark A. Perazella, Robert Dreicer, Mitchell H. Rosner Tags: Review Source Type: research

Sociodemographic disparities in the occurrence of medical conditions among adolescent and young adult Hodgkin lymphoma survivors
ConclusionStrategies to improve health care utilization for surveillance and secondary prevention among AYA HL survivors at increased risk of medical conditions may improve outcomes. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - April 13, 2018 Category: Cancer & Oncology Source Type: research

Clusterin deficiency induces lipid accumulation and tissue damage in kidney
In this study, we examined the role of clusterin in renal lipid accumulation in clusterin-knockout mice and NRK52e tubular epithelial cells. Clusterin deficiency increased the expression of SREBP1 and its target genes and decreased malonyl-CoA decarboxylase protein levels in the kidney. Expression of the endocytic receptor, megalin, and scavenger receptor class A was increased in clusterin-deficient mice. Functional analysis of lipid metabolism also revealed that lipid uptake and triglyceride synthesis were increased and fatty acid oxidation was reduced, leading to increased lipid accumulation in clusterin-deficient mice. ...
Source: Journal of Endocrinology - April 13, 2018 Category: Endocrinology Authors: Heo, J.-Y., Kim, J.-E., Dan, Y., Kim, Y.-W., Kim, J.-Y., Cho, K. H., Bae, Y. K., Im, S.-S., Liu, K.-H., Song, I.-H., Kim, J.-R., Lee, I.-K., Park, S.-Y. Tags: Research Source Type: research

The association of serum angiogenic growth factors with renal structure and function in patients with adult autosomal dominant polycystic kidney disease
We report here the relationship of serum angiopoietin-1 (Ang-1), Ang-2, and vascular endothelial growth factor (VEGF) with total kidney volume (TKV), total cyst volume (TCV), and renal failure in adult ADPKD patients at various stages of CKD.MethodsThis cross-sectional study was conducted with 50 patients diagnosed with ADPKD and a control group of 45 age-matched healthy volunteers. In patient group, TKV and TCV were determined with upper abdominal magnetic resonance imaging, whereas in controls, TKV was determined with ultrasonography according to ellipsoid formula. Renal function was assessed with serum creatinine, estim...
Source: International Urology and Nephrology - April 13, 2018 Category: Urology & Nephrology Source Type: research

Helping Patients With ESRD and Earlier Stages of CKD to Quit Smoking
Publication date: Available online 13 April 2018 Source:American Journal of Kidney Diseases Author(s): Perry Formanek, Elizabeth Salisbury-Afshar, Majid Afshar Among the many adverse effects of tobacco exposure is the increased risk for progression of kidney disease. Individuals with chronic kidney disease (CKD), who already face increased cardiovascular event rates compared to the general population, are at even greater risk if they smoke. Despite these risks and the increased focus on smoking cessation in the general population in recent years, national guidelines have not specifically targeted individuals with CKD. The...
Source: American Journal of Kidney Diseases - April 13, 2018 Category: Urology & Nephrology Source Type: research

CKD and ESRD in US Hispanics
Publication date: Available online 13 April 2018 Source:American Journal of Kidney Diseases Author(s): Nisa Desai, Claudia M. Lora, James P. Lash, Ana C. Ricardo Hispanics are the largest racial/ethnic minority group in the United States, and they experience a substantial burden of kidney disease. Although the prevalence of chronic kidney disease (CKD) is similar or slightly lower in Hispanics than non-Hispanic whites, the age- and sex-adjusted prevalence rate of end-stage renal disease is almost 50% higher in Hispanics compared with non-Hispanic whites. This has been attributed in part to faster CKD progression among His...
Source: American Journal of Kidney Diseases - April 13, 2018 Category: Urology & Nephrology Source Type: research

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease
CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease, Published online: 13 April 2018; doi:10.1038/s41581-018-0001-yPatients who present with chronic kidney disease and diabetes mellitus can have true diabetic kidney disease (DKD), nondiabetic kidney disease (NDKD), or a combination of both DKD and NDKD. Here, Anders and colleagues discuss the mechanisms underlying these entities and how greater appreciation of distinctions between these entities might facilitate the development of new treatments. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 13, 2018 Category: Urology & Nephrology Authors: Hans-Joachim Anders Tobias B. Huber Berend Isermann Mario Schiffer Source Type: research

Retinal capillary and arteriolar changes in patients with chronic kidney disease
Conclusion Patients with moderately severe CKD show retinal signs of end-organ damage indicated by an increased wall-to-lumen ratio and capillary rarefaction. (Source: Microvascular Research)
Source: Microvascular Research - April 13, 2018 Category: Biochemistry Source Type: research

The Impact of Preexisting Chronic Kidney Disease on the Severity and Recovery of Acute Kidney Injury
Conclusion: Taken together, reduced nephron mass have a negative effect on the repair process that is partially mediated by the disruption of the cell cycle regulation.Nephron (Source: Nephron)
Source: Nephron - April 12, 2018 Category: Urology & Nephrology Source Type: research

Urinary Angiotensinogen Excretion in Australian Indigenous and Non-Indigenous Pregnant Women
Publication date: Available online 11 April 2018 Source:Pregnancy Hypertension Author(s): Kirsty G. Pringle, Celine Corbisier de Meaultsart, Shane D. Sykes, Loretta J. Weatherall, Lyniece Keogh, Don C. Clausen, Gus A. Dekker, Roger Smith, Claire T. Roberts, Kym M. Rae, Eugenie R. Lumbers The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal diseas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - April 12, 2018 Category: OBGYN Source Type: research

Prevalence of Multiple Chronic Conditions Among Older Adults in Florida and the United States: Comparative Analysis of the OneFlorida Data Trust and National Inpatient Sample
Conclusions: The results showed that chronic conditions and multiple chronic conditions are prevalent in older adults across Florida and the United States. Even though slight differences were observed, the similar estimates of prevalence of chronic conditions and multiple chronic conditions across OneFlorida and HCUP NIS suggested that clinical research data networks such as OneFlorida, built from heterogeneous data sources, can provide rich data resources for conducting large-scale secondary data analyses. (Source: Journal of Medical Internet Research)
Source: Journal of Medical Internet Research - April 12, 2018 Category: General Medicine Authors: Zhe He Jiang Bian Henry J Carretta Jiwon Lee William R Hogan Elizabeth Shenkman Neil Charness Source Type: research

Physiology and pathophysiology of renal erythropoietin-producing cells
Publication date: Available online 11 April 2018 Source:Journal of the Formosan Medical Association Author(s): Hong-Mou Shih, Chih-Jen Wu, Shuei-Liong Lin Anemia is a common complication and contributes to increased morbidity and mortality in chronic kidney disease (CKD) patients. Whereas there has been a significant improvement of understanding the underlying mechanism of erythropoiesis, the treatment of renal anemia is still restricted to erythropoietin (EPO)-stimulating agents. The purpose of this article is to review the physiology of erythropoiesis, functional role of EPO and underlying molecular and cellular basis t...
Source: Journal of the Formosan Medical Association - April 12, 2018 Category: General Medicine Source Type: research

Sagittal abdominal diameter and Framingham risk score in non-dialysis chronic kidney disease patients
AbstractBackgroundChronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that abdominal obesity is a risk factor for cardiovascular mortality. We investigated the link between sagittal abdominal diameter (SAD) and Framingham risk score in non-dialysis CKD patients.MethodsIn a cross-sectional study, we enrolled 307 prevalent non-dialysis CKD patients (175 males, aged 50.7  ± 17.04 years). SAD and Framingham risk score were measured.ResultsFramingham cardiovascular disease risk score was independently predicted by SAD (P 
Source: International Urology and Nephrology - April 12, 2018 Category: Urology & Nephrology Source Type: research

Diversity of the midstream urine microbiome in adults with chronic kidney disease
AbstractPurposeTo examine the characteristics of the midstream urine microbiome in adults with stage 3 –5 non-dialysis-dependent chronic kidney disease (CKD).MethodsPatients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR]    50% reads) by the generaCorynebacterium (n = 11),Staphylococcus (n = 9),Streptococcus (n = 7),Lactobacillus (n = 7),Gardnerella (n = 7),Prevotella (n = 4),Escherichia_Shigella (n = 3), andEnterobacteriaceae (n = 2); the rest lacked a dominant g...
Source: International Urology and Nephrology - April 12, 2018 Category: Urology & Nephrology Source Type: research

Off-pump technique reduces operative mortality after elective coronary artery bypass grafting in patients with preoperative renal failure
This study was performed to evaluate the association between the clinical benefit of the off-pump technique and chronic kidney disease (CKD) stage. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 12, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Chikara Ueki, Hiroaki Miyata, Noboru Motomura, Ryuzo Sakata, Genichi Sakaguchi, Takehide Akimoto, Shinichi Takamoto Source Type: research

Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure
Conclusions Compared with enalapril, sacubitril/valsartan led to a slower rate of decrease in the eGFR and improved cardiovascular outcomes, even in patients with chronic kidney disease, despite causing a modest increase in UACR. Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 12, 2018 Category: Cardiology Source Type: research

Improving the prognosis of patients with severely decreased glomerular filtration rate (CKD G4+): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Patients with severely decreased glomerular filtration rate (GFR) (i.e., chronic kidney disease [CKD] G4+) are at increased risk for kidney failure, cardiovascular disease (CVD) events (including heart failure), and death. However, little is known about the variability of outcomes and optimal therapeutic strategies, including initiation of kidney replacement therapy (KRT). Kidney Disease: Improving Global Outcomes (KDIGO) organized a Controversies Conference with an international expert group in December 2016 to address this gap in knowledge. (Source: Kidney International)
Source: Kidney International - April 12, 2018 Category: Urology & Nephrology Authors: Kai-Uwe Eckardt, Nisha Bansal, Josef Coresh, Marie Evans, Morgan E. Grams, Charles A. Herzog, Matthew T. James, Hiddo J.L. Heerspink, Carol A. Pollock, Paul E. Stevens, Manjula Kurella Tamura, Marcello A. Tonelli, David C. Wheeler, Wolfgang C. Winkelmayer Tags: KDIGO Executive Conclusions Source Type: research

Different rates of progression and mortality in patients with chronic kidney disease at outpatient nephrology clinics across Europe
The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correct...
Source: Kidney International - April 12, 2018 Category: Urology & Nephrology Authors: Katharina Br ück, Kitty J. Jager, Carmine Zoccali, Aminu K. Bello, Roberto Minutolo, Kyriakos Ioannou, Francis Verbeke, Henry Völzke, Johan Arnlöv, Daniela Leonardis, Pietro Manuel Ferraro, Hermann Brenner, Ben Caplin, Philip A. Kalra, Christoph Wanner Tags: Clinical Investigation Source Type: research