Long-term functional outcomes in patients undergoing radical nephrectomy for renal cell carcinoma and tumor thrombus
ConclusionsThe presence of TT in RCC patients represents a key risk factor for worse perioperative, as well as long-term renal function. Specifically, patients with TT harbor a significant and early estimated glomerular filtration rate (eGFR) decrease. However, despite TT patients show a greater eGFR decline after surgery, they retain acceptable renal function, which remains stable over time. (Source: World Journal of Urology)
Source: World Journal of Urology - April 27, 2024 Category: Urology & Nephrology Source Type: research
Assessment of regional and total skeletal metabolism using 18F-NaF PET/CT in patients with chronic kidney disease
ConclusionsThe assessment of total skeleton and regional metabolism and bone turnover in CKD patients is feasible with Na[18F]F PET. Na[18F]F can help to detect early changes in bone metabolism and assess the progression of bone disease in this complex condition. Quantification with Na[18F]F PET might provide better assessment of the bone turnover. The difference in Na[18F]F uptake in CKD compared to controls is likely related to a change in bone turnover which, however, requires further validation. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 27, 2024 Category: Nuclear Medicine Source Type: research
Association of soluble suppression of tumorigenicity 2 with mortality and adverse outcomes in chronic kidney disease: a systematic review and meta-analysis
ConclusionsHigh sST2 values are associated with an increased risk of all-cause mortality in pre-dialysis and dialysis patients, as well as with an elevated risk of cardiovascular mortality in the dialysis population. Further studies are needed to elucidate its potential association with cardiovascular events and kidney disease progression. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 27, 2024 Category: Urology & Nephrology Source Type: research
Stroke prevention in atrial fibrillation with chronic kidney disease: a delicate balance of efficacy and safety considerations
Res Pract Thromb Haemost. 2024 Mar 15;8(2):102370. doi: 10.1016/j.rpth.2024.102370. eCollection 2024 Feb.NO ABSTRACTPMID:38666063 | PMC:PMC11043628 | DOI:10.1016/j.rpth.2024.102370 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 26, 2024 Category: Hematology Authors: Geoffrey D Barnes Julie A Wright Nunes Source Type: research
Roles of AhR/CYP1s Signal Pathway Mediated ROS Production in Uremic Cardiomyopathy
CONCLUSION: This study provides evidence that the AhR/CYP1s pathway is activated in UCM rats, and this activation is correlated with the uremic toxin IS. In vitro studies indicate that IS can stimulate the AhR translocation in cardiomyocyte, triggering to the production of intracellular ROS via CYP1s. This process leads to prolonged oxidative stress stimulation and thus contributes to the progression of uremic toxin-mediated cardiomyopathy.PMID:38670245 | DOI:10.1016/j.toxlet.2024.04.005 (Source: Toxicology Letters)
Source: Toxicology Letters - April 26, 2024 Category: Toxicology Authors: Wei Lu Shi Cheng Jiarui Xu Zilong Xiao Yong Yu Qiwen Xie Yi Fang Ruizhen Chen Bo Shen Yeqing Xie Xiaoqiang Ding Source Type: research
Novel insights into the protective effects of leonurine against acute kidney injury: inhibition of ER stress-associated ferroptosis via regulating ATF4/CHOP/ACSL4 pathway
This study aimed to explore the benefits of leonurine on AKI and the possible mechanisms involved, mainly focusing on the regulation of ferroptosis and endoplasmic reticulum (ER) stress. Our results showed that leonurine exhibited prominent protective effects against AKI, as evidenced by the amelioration of histopathological alterations and reduction of renal dysfunction. In addition, leonurine significantly suppressed ferroptosis in AKI both in vivo and in vitro by effectively restoring ultrastructural abnormalities in mitochondria, decreasing ASCL4 and 4-HNE levels, scavenging reactive oxygen species (ROS), as well as in...
Source: Chemico-Biological Interactions - April 26, 2024 Category: Molecular Biology Authors: Ran Cheng Xiaowan Wang Lihua Huang Zhisheng Lu Aijun Wu Shan Guo Chuang Li Wei Mao Ying Xie Peng Xu Ruimin Tian Source Type: research
Metabolically healthy obesity and health risks - a review of meta-analyses
CONCLUSION: Based on the results of meta-analyses, we recommend motivating all obese patients to change their lifestyle regardless of the presence of metabolic defects.PMID:38669161 | DOI:10.21101/cejph.a7806 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Erika Čermáková Martin Forejt Source Type: research
Relationship between arginine methylation and vascular calcification
Cell Signal. 2024 Apr 24:111189. doi: 10.1016/j.cellsig.2024.111189. Online ahead of print.ABSTRACTIn patients on maintenance hemodialysis (MHD), vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD), which is the primary cause of death in chronic kidney disease (CKD). The main component of VC in CKD is the vascular smooth muscle cells (VSMCs). VC is an ordered, dynamic activity. Under the stresses of oxidative stress and calcium‑phosphorus imbalance, VSMCs undergo osteogenic phenotypic transdifferentiation, which promotes the formation of VC. In addition to traditional epigenetics like ...
Source: Cellular Signalling - April 26, 2024 Category: Cytology Authors: Chen Chen Yuanyuan Ding Qun Huang Chen Zhang Zixia Zhao Hua Zhou Detian Li Guangyu Zhou Source Type: research
Immunocompromised individuals are at increased risk of COVID ‐19 breakthrough infection, hospitalization, and death in the post‐vaccination era: A systematic review
ConclusionThis demonstrated that vaccination does not offer an adequate level of protection in these groups, necessitating further measures such as Evusheld and further boosters. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 26, 2024 Category: Allergy & Immunology Authors: Jola Bytyci,
Yuxin Ying,
Lennard Y. W. Lee Tags: REVIEW ARTICLE Source Type: research
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis
Chronic kidney disease (CKD) is a serious health problem worldwide, which ultimately leads to end-stage renal disease (ESRD). Renal fibrosis is the common pathway and major pathological manifestation for various CKD proceeding to ESRD. However, the underlying mechanisms and effective therapies are still ambiguous. Early growth response 2 (EGR2) is reportedly involved in organ formation and cell differentiation. To determine the role of EGR2 in renal fibrosis, we respectively confirmed the increased expression of EGR2 in kidney specimens from both CKD patients and mice with location in proximal tubules. (Source: Translational Research)
Source: Translational Research - April 26, 2024 Category: Research Authors: Anni Song, Ruiwei Yan, Wei Xiong, Huiling Xiang, Jing Huang, Anni Jiang, Chun Zhang Source Type: research
Prognostic nutritional index as a predictive marker for acute kidney injury in adult critical illness population: a systematic review and diagnostic test accuracy meta-analysis
ConclusionOur study demonstrated that PNI has practical accuracy for predicting the development of AKI in critically ill populations, with superior diagnostic performance observed in medical and non-CKD populations. However, the diagnostic efficacy of the PNI has significant heterogeneity with different cutoff value, indicating the need for further research. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - April 26, 2024 Category: Intensive Care Source Type: research
CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research
Incorporating genetic testing into a routine kidney clinic
In conclusion, utilizing genetic testing in a routine outpatient renal clinic did not cause any burden to either patients or nephrologists, with minimal administrative effort and no financial cost to our patients. We expect that genetic testing in the right setting should become routine in nephrology to achieve a patient-centered precision medicine with less invasive means of kidney disease diagnosis.PMID:38660889 | DOI:10.5414/CN111138 (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 25, 2024 Category: Urology & Nephrology Authors: Jingjing Zhang Wing Zeng Seyed Hamrahian Omar H Maarouf Source Type: research
Inspiratory Muscle Training in Patients Living with Chronic Kidney Disease and Receiving Hemodialysis: Meta-Analysis of Randomized Controlled Trials
CONCLUSIONS: IMT improves MIP, MEP, and functional capacity in people living with CKD and receiving HD. IMT did not demonstrate significant results for lung function and quality of life. Effects on endothelial function and oxidative capacity remain uncertain.IMPACT: Inspiratory muscle training improves MIP, MEP, and functional capacity in people living with CKD and receiving HD, compared with conventional physical therapy or controls or placebo intervention. Increases in functional capacity in this population are extremely important because of the relationship with the survival of these people.PMID:38662569 | DOI:10.1093/p...
Source: Physical Therapy - April 25, 2024 Category: Physiotherapy Authors: Ana Karla Vieira Br üggemann Jociane Schardong Natiele Camponogara Righi Rodrigo Della M éa Plentz Source Type: research
Survival, cumulative hospital days and infectious complications in urgent-start PD compared with urgent-start HD
CONCLUSIONS: Patient survival, cumulative first-year hospital care days and total KRT-related infection rate at 3 months and 1-year follow-up are similar between urgent-start PD and urgent-start HD patients. Furthermore, CVC insertion rate is associated with incident blood culture-positive bacteraemia and increased cumulative first-year hospital care days.PMID:38661183 | DOI:10.1177/08968608241244939 (Source: Peritoneal Dialysis International)
Source: Peritoneal Dialysis International - April 25, 2024 Category: Urology & Nephrology Authors: Jonna Virtanen Maija Heiro Niina Koivuviita Eliisa L öyttyniemi Mikko J J ärvisalo Risto Tertti Kaj Mets ärinne Tapio Hellman Source Type: research
