Incomplete Distal Renal Tubular Acidosis and Kidney Stones
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Daniel G. Fuster, Orson W. MoeRenal tubular acidosis (RTA) is comprised of a diverse group of congenital or acquired diseases with the common denominator of defective renal acid excretion with protean manifestation, but in adults, recurrent kidney stones and nephrocalcinosis are mainly found in presentation. Calcium phosphate (CaP) stones and nephrocalcinosis are frequently encountered in distal hypokalemic RTA type I. Alkaline urinary pH, hypocitraturia, and, less frequently, hypercalciuria are the tripartite lithogenic fac...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Pseudo-Renal Tubular Acidosis: Conditions Mimicking Renal Tubular Acidosis
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Junior Uduman, Jerry YeeHyperchloremic metabolic acidosis, particularly renal tubular acidosis, can pose diagnostic challenges. The laboratory phenotype of a low total carbon dioxide content, normal anion gap, and hyperchloremia may be misconstrued as hypobicarbonatemia from renal tubular acidosis. Several disorders can mimic renal tubular acidosis, and these must be appropriately diagnosed to prevent inadvertent and inappropriate application of alkali therapy. Key physiologic principles and limitations in the assessment of ...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Clinical Approach to Proximal Renal Tubular Acidosis in Children
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Gal Finer, Daniel LandauProximal renal tubular acidosis (pRTA) is an inherited or acquired clinical syndrome in which there is a decreased bicarbonate reclamation in the proximal tubule resulting in normal anion gap hyperchloremic metabolic acidosis. In children, pRTA may be isolated but is often associated with a general proximal tubular dysfunction known as Fanconi syndrome which frequently heralds an underlying systemic disorder from which it arises. When accompanied by Fanconi syndrome, pRTA is characterized by additiona...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Renal Tubular Acidosis: H+/Base and Ammonia Transport Abnormalities and Clinical Syndromes
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Ira KurtzRenal tubular acidosis (RTA) represents a group of diseases characterized by (1) a normal anion gap metabolic acidosis; (2) abnormalities in renal HCO3− absorption or new renal HCO3− generation; (3) changes in renal NH4+, Ca2+, K+, and H2O homeostasis; and (4) extrarenal manifestations that provide etiologic diagnostic clues. The focus of this review is to give a general overview of the pathogenesis of the various clinical syndromes causing RTA with a particular emphasis on type I (hypokalemic distal RTA...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Hyperkalemic Forms of Renal Tubular Acidosis: Clinical and Pathophysiological Aspects
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Daniel Batlle, Jose ArrudaIn contrast to distal type I or classic renal tubular acidosis (RTA) that is associated with hypokalemia, hyperkalemic forms of RTA also occur usually in the setting of mild-to-moderate CKD. Two pathogenic types of hyperkalemic metabolic acidosis are frequently encountered in adults with underlying CKD. One type, which corresponds to some extent to the animal model of selective aldosterone deficiency (SAD) created experimentally by adrenalectomy and glucocorticoid replacement, is manifested in human...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Hypokalemic Distal Renal Tubular Acidosis
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Patricia G. Vallés, Daniel BatlleDistal renal tubular acidosis (DRTA) is defined as hyperchloremic, non-anion gap metabolic acidosis with impaired urinary acid excretion in the presence of a normal or moderately reduced glomerular filtration rate. Failure in urinary acid excretion results from reduced H+ secretion by intercalated cells in the distal nephron. This results in decreased excretion of NH4+ and other acids collectively referred as titratable acids while urine pH is typically above 5.5 in the face of systemi...
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Renal Tubular Acidosis and the Nephrology Teaching Paradigm
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Daniel Batlle, Jose Arruda (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

It Is Really Time for Ammonium Measurement
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): Kalani L. Raphael, Jerry Yee (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Masthead
Publication date: July 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 4Author(s): (Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - August 21, 2018 Category: Urology & Nephrology Source Type: research

Energy sensor as a new regulator of FGF23 synthesis
Phosphate plays an important role in biological energy cycle, but the interaction of cellular energy metabolism with fibroblast growth factor 23 production has been less well characterized. Glosse and colleagues now demonstrate that AMP-activated protein kinase, a cellular energy sensor, regulates fibroblast growth factor 23 production. Interestingly, AMP-activated protein kinase –deficient mice show high fibroblast growth factor 23 levels, normal phosphate levels, and cardiac hypertrophy, which resemble those seen in patients with moderate chronic kidney disease. (Source: Kidney International)
Source: Kidney International - August 21, 2018 Category: Urology & Nephrology Authors: Hirotaka Komaba Tags: Commentary Source Type: research

Utilization, costs, and outcomes for patients receiving publicly funded hemodialysis in  India
Lifestyle transitions are making chronic conditions such as chronic kidney disease increasingly common in low- and middle-income countries, including India. According to the 2016 Global Burden of Disease Study, chronic kidney disease was the ninth leading cause of death in India, having risen from 15th rank in 2005 (http://www.healthdata.org/india). In a recent analysis of deaths in 1.1 million Indian households, renal failure was responsible for 2.9% of all deaths among 15 –69-year-olds in 2010–2013, an increase of 50% from 2001–2003. (Source: Kidney International)
Source: Kidney International - August 21, 2018 Category: Urology & Nephrology Authors: Maaz Shaikh, Mark Woodward, Oommen John, Abhinav Bassi, Stephen Jan, Manisha Sahay, Gangadhar Taduri, Martin Gallagher, John Knight, Vivekanand Jha Tags: Nephrologists Sans Fronti ères Source Type: research

Hyponatremia Predicts Poor Outcomes in Patients With Chronic Kidney Disease Undergoing Heart Operation
Publication date: September 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 3Author(s): Linda Shavit, Ofer Merin, Tal Grenader, Ehud Jacobson, Chani Waldenberg, Daniel Bitran, Daniel Fink, Shuli SilbermanBackgroundPreoperative hyponatremia adversely affects outcomes of cardiothoracic operation. However, in patients with chronic kidney disease, the association of sodium levels on postoperative events has never been evaluated. We investigated the impact of preoperative hyponatremia on outcomes after cardiac operation in patients with non–dialysis-dependent chronic kidney disease. Primary end points were o...
Source: The Annals of Thoracic Surgery - August 21, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress
Publication date: Available online 20 August 2018Source: Redox BiologyAuthor(s): Ge Chenxu, Xu Minxuan, Qin Yuting, Gu Tingting, Lv Jinxiao, Wang Mingxing, Wang Sujun, Ma Yongjie, Lou Deshuai, Li Qiang, Hu Linfeng, Tan JunAbstractParticulate matter (PM2.5) is a risk factor for organ injury and disease progression, such as lung, brain and liver. However, its effects on renal injury and the underlying molecular mechanism have not been understood. The inactive rhomboid protein 2 (iRhom2), also known as A disintegrin and metalloprotease 17 (ADAM17), is a necessary modulator for shedding of tumor necrosis factor-α (TNF-&a...
Source: Redox Biology - August 21, 2018 Category: Biology Source Type: research

The effect of hemodialysis on the body composition and cardiovascular disease markers in recently diagnosed end stage renal disease patients
CONCLUSIONS: HD significantly improves PWV in patients reaching dry weight. Reduction of fluid excess by ultrafiltration in HD patients may reduce CV mortality by reducing arterial stiffness.RESUMO INTRODU ÇÃO: Em pacientes com doença renal crônica (DRC), toxinas urêmicas e hipervolemia contribuem para aumentar o risco cardiovascular. Nosso objetivo foi determinar o estado de hidratação em pacientes com DRC iniciando hemodiálise (HD) e avaliar os efeitos da correção da hipervolemia sobre o s istema cardiovascular. MÉTODOS: Foram incluídos 52 ...
Source: Revista da Associacao Medica Brasileira - August 21, 2018 Category: General Medicine Source Type: research

Frailty, Health-Related Quality of Life, Cognition, Depression, Vitamin D and Health-Care Utilization in an Ambulatory Adult Population with Type 1 or Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Cross-Sectional Analysis
Publication date: Available online 20 June 2018Source: Canadian Journal of DiabetesAuthor(s): Stephany I. Adame Perez, Peter A. Senior, Catherine J. Field, Kailash Jindal, Diana R. MagerAbstractObjectivesFrailty can cause increased vulnerability to adverse health outcomes, such as falls, fractures, depression and reduced health-related quality of life (HRQoL). This cross-sectional study compared the differences in body composition, HRQoL, mental health and cognitive and vitamin D (vitD) status with health-care utilization by frail and nonfrail adults with diabetes mellitus (type 1 and type 2) and with chronic kidney diseas...
Source: Canadian Journal of Diabetes - August 21, 2018 Category: Endocrinology Source Type: research

Cardiorenal Interactions Revisited: How to Improve Heart Failure Outcomes in Patients With Chronic Kidney Disease
AbstractPurpose of the ReviewTo summarize current advances in the understanding and management of heart failure (HF) in patients with advanced chronic kidney disease (CKD).Recent FindingsDiagnosis of HF and treatment of congestion are crucial in the management of patients with advanced CKD to reduce symptoms, preserve organ function, and improve outcomes. Echocardiography and cardiovascular biomarkers may help to differentiate cardiac from non-cardiac components of overhydration. Renal replacement therapy or ultrafiltration may be required to treat congestion. Furthermore, patients with advanced CKD are frequently undertre...
Source: Current Heart Failure Reports - August 20, 2018 Category: Cardiology Source Type: research

Prevalence and associated risk factors for osteoporosis in Korean men
AbstractSummaryOsteoporosis has become an important health concern even in men. We aimed to analyze its prevalence and associated factors in Korean men. Low socioeconomic status, unhealthy lifestyle, and chronic kidney disease increased the risk. High-risk men even at young age need to evaluate bone mineral density, and proper interventions should be reinforced.PurposeOwing to an increase in the elderly population, osteoporosis and consequent fractures have become important health concerns even in men. We aimed to analyze the prevalence of osteoporosis in Korean men and identify risk factors associated with male osteoporos...
Source: Archives of Orthopaedic and Trauma Surgery - August 20, 2018 Category: Orthopaedics Source Type: research

Body mass index in an Australian population with chronic kidney disease
Obesity emerged as the leading global health concern in 2017. Although higher body mass index (BMI) is a health risk in the general population, its implications for chronic kidney disease (CKD) are not entirel... (Source: BMC Nephrology)
Source: BMC Nephrology - August 20, 2018 Category: Urology & Nephrology Authors: Samuel Chan, Anne Cameron, Zaimin Wang, Sree K. Venuthurupalli, Ken S. Tan, Helen G. Healy and Wendy E. Hoy Tags: Research article Source Type: research

Chronic kidney disease progression in patients with chronic hepatitis B on tenofovir, entecavir, or no treatment
Alimentary Pharmacology&Therapeutics, EarlyView. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 20, 2018 Category: Drugs & Pharmacology Authors: Grace Lai ‐Hung Wong , Henry Lik‐Yuen Chan , Yee‐Kit Tse , Terry Cheuk‐Fung Yip , Kelvin Long‐Yan Lam , Grace Chung‐Yan Lui , Cheuk‐Chun Szeto , Vincent Wai‐Sun Wong Source Type: research

Correlation of electrophoretic urine protein banding patterns with severity of renal damage in dogs with proteinuric chronic kidney disease
Veterinary Clinical Pathology, EarlyView. (Source: Veterinary Clinical Pathology)
Source: Veterinary Clinical Pathology - August 20, 2018 Category: Veterinary Research Authors: Jessica A. Hokamp , Sidney L. Leidy , Irina Gaynanova , Rachel E. Cianciolo , Mary B. Nabity Source Type: research

Effects of CoCl2-simulated hypoxia on the expression levels of matrix metalloproteinases in renal adenocarcinoma cells and renal tubular epithelial cells.
Authors: Zhang X, Chen L Abstract Renal cell carcinoma (RCC) and chronic kidney disease (CKD) are associated with hypoxia, but the effects of hypoxia on the process of angiogenesis in the two diseases are dramatically different. Some of matrix metalloproteinases (MMPs), such as MMP2 and MMP9, may have a role because they represent the most prominent family of proteinases associated with angiogenesis. In the present study, the differential response of human renal cell cancer cells (786-0), human renal tubular epithelial cells (HK-2) and human microvascular endothelial cells (HMEC-1) to hypoxia with regards to the ex...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Impact of timing of initiation of dialysis on long-term prognosis of patients undergoing hemodialysis.
Authors: Zhang Y, Hu C, Bian Z, Chen P Abstract There are a lot of controversies pertaining to correctness of timing for the initiation of dialysis in chronic kidney disease (CKD) patients. The present study was conducted to examine the potential association of initiation timing of dialyses with long-term prognosis in CKD patients. In total, 294 patients confirmed as end-stage renal disease (ESRD) were included as study subjects. According to the estimated glomerular filtration rate (eGFR) at initiation time, the patients were classified into four groups based on eGFR: ≥10.5, 8-10.4, 6-8 and
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Safety and efficacy of lithium in children and adolescents: A systematic review in bipolar illness
ConclusionsThough the available literature is mostly short-term, there is evidence that lithium monotherapy is reasonably safe and effective in children and adolescents, specifically for acute mania and for prevention of mood episodes. (Source: European Psychiatry)
Source: European Psychiatry - August 18, 2018 Category: Psychiatry Source Type: research

Projecting the Burden of Chronic Kidney Disease in a Developed Country and Its Implications on Public Health.
Conclusion: By 2035, about one-quarter of the Singapore residents are expected to have CKD. National policies need to focus on primary disease prevention and early disease detection to avoid delayed treatment of CKD which eventually leads to end-stage renal disease. PMID: 30112209 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 18, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Diagnostic concordance between NT-proBNP and BNP for suspected heart failure.
This study sought to assess diagnostic concordance of BNP and NT-proBNP for ruling in and ruling out heart failure (HF). METHODS: Simultaneous BNP and NT-proBNP testing was performed on 2729 patient samples with routinely ordered BNP testing. Hospital location, age, sex, creatinine, BNP and NT-proBNP were also recorded. Recommended cutoffs for BNP and NT-proBNP for ruling in and out HF were used for assessing diagnostic concordance and correlation. RESULTS: In the ED setting, concordance between BNP and NT-proBNP was 0.695 (95% CI, 0.668-0.723) by weighted kappa using the recommended cutoffs for the acute setting...
Source: Clinical Biochemistry - August 18, 2018 Category: Biochemistry Authors: Farnsworth CW, Bailey AL, Jaffe AS, Scott MG Tags: Clin Biochem Source Type: research

mEpoR KO / Tg(hEpoR) Mouse
mEpoR-/- hEpoR+: The mouse Erythropoietin Receptor knockout that contains a human Erythropoietin Receptor transgene can be used to define the potency of recombinant erythropoietin preparations used to treat anemia associated with chronic kidney disease.Erythropoietin, acting by binding to Erythropoietin receptors (EpoR) on erythroid progenitor cells, is required for erythropoiesis. Absence of erythropoietin or the EpoR in mice interrupts erythropoiesis in the fetal liver and result in death at embryonic day 13.5. An 80-kb human EpoR transgene bred onto a mouse EpoR null background (provided by F. Constantini of Columbia Un...
Source: NIDDK Research Resources - August 17, 2018 Category: Endocrinology Source Type: research

Higher Prevalence and Progression Rate of Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus.
Authors: Kim KS, Park SW, Cho YW, Kim SK Abstract BACKGROUND: To evaluate the prevalence of chronic kidney disease (CKD) and progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: We investigated the medical records of 190 elderly patients (65 years or older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR)
Source: Diabetes and Metabolism Journal - August 17, 2018 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population
Conclusion: In this single-center study with moderate sample size, the data showed no relationship of PCSK9 levels with normal or decreased eGFR in untreated patients with normal SCr, suggesting that further studies may be needed to understand the relationship between PCSK9 and lipid disorder in different stage of kidney dysfunction.Cardiorenal Med 2018;8:311 –320 (Source: Cardiorenal Medicine)
Source: Cardiorenal Medicine - August 17, 2018 Category: Urology & Nephrology Source Type: research

Radial versus femoral artery access in patients undergoing PCI for left main coronary artery disease: analysis from the EXCEL trial.
CONCLUSIONS: In the EXCEL trial, PCI of LM disease with TRA was associated with comparable early and late clinical outcomes as TFA. PMID: 30111521 [PubMed - as supplied by publisher] (Source: EuroIntervention)
Source: EuroIntervention - August 17, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Assessing benefit versus risk of complex percutaneous coronary intervention in people with chronic kidney disease
Publication date: Available online 16 August 2018Source: Canadian Journal of CardiologyAuthor(s): Bryan J. Har, Matthew T. James (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - August 17, 2018 Category: Cardiology Source Type: research

IJERPH, Vol. 15, Pages 1773: Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies
Seguro Vitamin D (VD) is a pro-hormone essential for life in higher animals. It is present in few types of foods and is produced endogenously in the skin by a photochemical reaction. The final step of VD activation occurs in the kidneys involving a second hydroxylation reaction to generate the biologically active metabolite 1,25(OH)2-VD. Extrarenal 1α-hydroxylation has also been described to have an important role in autocrine and paracrine signaling. Vitamin D deficiency (VDD) has been in the spotlight as a major public healthcare issue with an estimated prevalence of more than a billion people worldwid...
Source: International Journal of Environmental Research and Public Health - August 17, 2018 Category: Environmental Health Authors: Pedro Henrique Franca Gois Martin Wolley Dwarakanathan Ranganathan Antonio Carlos Seguro Tags: Review Source Type: research

O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats [Molecular Bases of Disease]
In conclusion, our results demonstrate a new mechanism involved in hypertension-associated proteinuria. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - August 17, 2018 Category: Chemistry Authors: Rodrigo Pacheco Silva–Aguiar, Nathalia C. F. Bezerra, Miguel C. Lucena, Gabriela M. Sirtoli, Roberto T. Sudo, Gisele Zapata–Sudo, Christina M. Takiya, Ana Acacia S. Pinheiro, Wagner Barbosa Dias, Celso Caruso–Neves Tags: Signal Transduction Source Type: research

The impact of a nutrition intervention program targeting elderly people with chronic kidney disease
Resumo A doen ça renal crônica (DRC) é complexa, exigindo múltiplas abordagens em seu tratamento. O objetivo do presente estudo foi avaliar o impacto de um programa de intervenção nutricional sobre o estado nutricional e a qualidade de vida de idosos com DRC não dialítica. Foi realizada uma coorte prospec tiva com 64 idosos, de ambos os sexos, com DRC estágio 3, atendidos em Unidade Básica de Saúde, em Diadema/SP. A intervenção nutricional consistiu em três encontros coletivos e um individual. O estado nutricional foi avaliado p...
Source: Ciencia e Saude Coletiva - August 16, 2018 Category: Occupational Health Source Type: research

Renal Disorders in Pregnancy: Core Curriculum 2019
Publication date: Available online 16 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Maria L. Gonzalez Suarez, Andrea Kattah, Joseph P. Grande, Vesna GarovicAs the incidence of chronic kidney disease increases and women pursue pregnancy at more advanced ages, the management of kidney disease in pregnancy has become increasingly relevant to the practicing nephrologist. Women with kidney disorders face several challenges in pregnancy due to increased physiologic demands on the kidney and risk for disease progression, the potential teratogenicity of medications, and the increased risk for complications such ...
Source: American Journal of Kidney Diseases - August 16, 2018 Category: Urology & Nephrology Source Type: research

Jian-Pi-Yi-Shen Formula Regulates Inflammatory Cytokines Production in 5/6 Nephrectomized Rats via Suppression of NF- κB Activation.
In conclusion, our data demonstrated that JPYSF remarkably retards development and progression of CKD in a 5/6 Nx rat model, which may be associated with inhibition of inflammation via NF-κB signaling pathway. PMID: 30108662 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Anti VEGF-TKI Treatment and New Renal Adverse Events Not Reported in Phase III Trials
In conclusion, these 2 c ases argue for increased awareness for the possibility of renal failure as a consequence of anti-VEFG treatment. Predisposing conditions like known mild chronic renal insufficiency with only mild proteinuria and with atherosclerosis or precipitating co-medications like zoledronate infusion need to b e accounted for to prevent these severe AEs.Eur Thyroid J (Source: European Thyroid Journal)
Source: European Thyroid Journal - August 16, 2018 Category: Endocrinology Source Type: research

Light Chain Amyloidosis Presenting as Bilateral External Auditory Canal Obstructing Masses
A morbidly-obese 57-year-old diabetic and hypertensive man with chronic kidney disease, diastolic heart failure, and bilateral hearing loss was found to have soft tissue masses/densities in the lateral aspect of both auditory canals on local examination and on imaging. He underwent biopsies of both ear canal masses and histologic examination revealed amyloid deposits in the dermis. These deposits were confirmed as AL (amyloid light chain) kappa-type amyloid by laser mass spectrometry. A systemic work-up showed plasma cell dyscrasia with 9% kappa light chain restricted plasma cells in the bone marrow as well as amyloid depo...
Source: Otology and Neurotology - August 16, 2018 Category: ENT & OMF Tags: Temporal Bone Histopathology Case of the Month Source Type: research

Predictors of bone fractures in a single-centre cohort of hemodialysis patients: a 2-year follow-up study
ConclusionsIn a group of hemodialysis patients from one centre, T-score in proximal femur, low vitamin D, low BMI, and high FRAX for major osteoporotic fracture were associated with low-trauma fractures, however, in multi-variate analysis only low BMI remained a significant predictor of fracture risk. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - August 16, 2018 Category: Urology & Nephrology Source Type: research

Value-based evaluation of dialysis versus conservative care in older patients with advanced chronic kidney disease: a cohort study
Conservative care is argued to be a reasonable treatment alternative for dialysis in older patients with advanced chronic kidney disease (CKD). However, comparisons are scarce and generally focus on survival o... (Source: BMC Nephrology)
Source: BMC Nephrology - August 16, 2018 Category: Urology & Nephrology Authors: Wouter R. Verberne, Janneke Dijkers, Johannes C. Kelder, Anthonius B. M. Geers, Wilbert T. Jellema, Hieronymus H. Vincent, Johannes J. M. van Delden and Willem Jan W. Bos Tags: Research article Source Type: research

Increased risk of deep vein thrombosis in end-stage renal disease patients
Previous studies have shown that chronic kidney disease increases the risk of deep vein thrombosis (DVT). DVT is the risk of pulmonary embolism among persons with end-stage renal disease (ESRD). Information on... (Source: BMC Nephrology)
Source: BMC Nephrology - August 16, 2018 Category: Urology & Nephrology Authors: Hsueh-Yi Lu and Kuang-Ming Liao Tags: Research article Source Type: research

PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition
ConclusionsPAX2 directly increased expression of ADAM10, the presence of which contributed to EMT in renal tubular epithelia and hence plays an important role in renal fibrosis. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - August 16, 2018 Category: Urology & Nephrology Source Type: research

Adequacy of Plant-Based Proteins in Chronic Kidney Disease
Concerns regarding protein and amino acid deficiencies with plant-based proteins have precluded their use in chronic kidney disease (CKD) patients. Many of these concerns were debunked years ago, but recommendations persist regarding the use of “high-biological value” (animal-based) proteins in CKD patients, which may contribute to worsening of other parameters such as blood pressure, metabolic acidosis, and hyperphosphatemia. Plant-based proteins are sufficient in meeting both quantity and quality requirements. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - August 16, 2018 Category: Urology & Nephrology Authors: Shivam Joshi, Sanjeev Shah, Kamyar Kalantar-Zadeh Tags: Practical Aspects Source Type: research

Long ‐term views on chronic kidney disease research priorities among stakeholders engaged in a priority‐setting partnership: A qualitative study
Health Expectations, EarlyView. (Source: Health Expectations)
Source: Health Expectations - August 16, 2018 Category: Health Management Authors: Meghan J. Elliott MD, MSc , Joanna E. M. Sale PhD , Zahra Goodarzi MD, MSc , Linda Wilhelm , Andreas Laupacis MD, MSc , Brenda R. Hemmelgarn MD, PhD , Sharon E. Straus MD, MSc Source Type: research

Progression to chronic kidney disease in patients undergoing nephrectomy for small renal masses: a price to pay for a therapeutic success?
Authors: Charytoniuk T, Małyszko M, Bączek J, Fiedorczyk P, Siedlaczek K, Małyszko J Abstract Nephrectomy, which constitutes a gold-standard procedure for the treatment of renal-cell carcinoma (RCC), has been widely discussed in the past decade as a significant risk factor of the development of chronic kidney disease (CKD). RCC is the third most common genitourinary cancer in the United States, with an estimated more than 65,000 new cases and 14,970 deaths. The aim of this review was to precisely and comprehensively summarize the status of current knowledge in chronic kidney disease risk factors after nephrectom...
Source: Postgraduate Medicine - August 15, 2018 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Serum Creatinine and Chronic Kidney Disease-Epidemiology Estimated Glomerular Filtration Rate: Independent Predictors of Renal Replacement Therapy following Cardiac Surgery
Conclusion: Preoperative renal function, defined by serum creatinine or eGFR by CKD-EPI, NYHA class II –IV, and the number of blood units transfused were all independent predictors of RRT postoperatively.Am J Nephrol 2018;48:108 –117 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Neurology Source Type: research

Clinical and Pathological Characteristics of Elderly Japanese Patients with IgA Vasculitis with Nephritis: A Case Series.
Conclusion IgAVN in elderly patients is characterized by severe renal involvement. Elderly patients are at higher risk than adults for treatment-related adverse events. PMID: 30101942 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - August 15, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Blood pressure components and incident cardiovascular disease and mortality events among Iranian adults with chronic kidney disease during over a decade long follow-up: a prospective cohort study
To explore the association between systolic and diastolic blood pressure (SBP and DBP respectively) and pulse pressure (PP) with cardiovascular disease (CVD) and mortality events among Iranian patients with pr... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 15, 2018 Category: Research Authors: Ashkan Hashemi, Sormeh Nourbakhsh, Samaneh Asgari, Mohammadhassan Mirbolouk, Fereidoun Azizi and Farzad Hadaegh Tags: Research Source Type: research

Serum Creatinine and Chronic Kidney Disease-Epidemiology Estimated Glomerular Filtration Rate: Independent Predictors of Renal Replacement Therapy following Cardiac Surgery.
CONCLUSION: Preoperative renal function, defined by serum creatinine or eGFR by CKD-EPI, NYHA class II-IV, and the number of blood units transfused were all independent predictors of RRT postoperatively. PMID: 30110680 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 15, 2018 Category: Urology & Nephrology Authors: Drosos G, Ampatzidou F, Sarafidis P, Karaiskos T, Madesis A, Boutou AK Tags: Am J Nephrol Source Type: research