Development and validation of a machine learning model to predict time to renal replacement therapy in patients with chronic kidney disease
Predicting time to renal replacement therapy (RRT) is important in patients at high risk for end-stage kidney disease. We developed and validated machine learning models for predicting the time to RRT and comp... (Source: BMC Nephrology)
Source: BMC Nephrology - March 16, 2024 Category: Urology & Nephrology Authors: Jun Okita, Takeshi Nakata, Hiroki Uchida, Akiko Kudo, Akihiro Fukuda, Tamio Ueno, Masato Tanigawa, Noboru Sato and Hirotaka Shibata Tags: Research Source Type: research

The moderating role of social support in the relationship between death anxiety and resilience among dialysis patients
Chronic Kidney Disease (CKD) who receive social support can cope with the challenges. Therefore, this study determined the moderating role of social support in the relationship between death anxiety and resili... (Source: BMC Nephrology)
Source: BMC Nephrology - March 16, 2024 Category: Urology & Nephrology Authors: Zahra Shafiei Kisomi, Omid Taherkhani, Mina Mollaei, Hoda Esmaeily, Ghazaleh Shirkhanloo, Zahra Hosseinkhani and Mohammad Amerzadeh Tags: Research Source Type: research

Low C3 in a 4-month-old baby: is it a problem?
AbstractA 4-month-old male baby was admitted because his father and uncles had chronic kidney disease. His father was diagnosed with membranoproliferative glomerulonephritis at the age of 5, underwent a kidney transplant at the age of 22, and lost the graft due to recurrence of the disease. In contrast, the young uncle was diagnosed with C3 glomerulopathy and mycophenolate mofetil and eculizumab were initiated early. It was remarkable that our patient had normal kidney function and urine analyses but low serum C3 level (0.56  g/L; N, 0.9–1.8 g/L). In the disease-associated clinical exome analysis, a heterozygous change...
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Protein energy wasting in children with chronic kidney disease: is lean body mass by DEXA a key diagnostic biomarker?
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Sleep disturbances in children and adolescents after kidney transplantation
ConclusionsA high prevalence of sleep disturbances has been identified in children after kidney transplants, and some risk factors may be modifiable. Further studies are required to understand whether there are other readily modifiable predictors of sleep disturbances.Graphical AbstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Effect of peritoneal dialysate on bioelectrical impedance analysis variability in pediatric patients receiving peritoneal dialysis
ConclusionsA total of 94.1% of BIA parameters exhibited excellent correlations between D  + and D- measurements, especially patients older than 10 years. We recommend that BIA measurements be collected from children regardless of the presence of peritoneal dialysate. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study
ConclusionMMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Complement gene mutations in children with C3 glomerulopathy: do they affect the response to mycophenolate mofetil?
ConclusionsThis study is the largest pediatric C3G study examining the relationship between genotype and phenotype. We showed that the mutation group often presented with asymptomatic urinary abnormalities, was diagnosed relatively late but was not different from the without mutation group in terms of MMF treatment response and kidney survival.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Water-soluble vitamins and trace elements in children with chronic kidney disease stage 5d
AbstractChildren receiving maintenance dialysis (chronic kidney disease (CKD) stage 5d) have unique risk factors for micronutrient deficiency or toxicity. Children receiving chronic dialysis often require specialized diet plans that may provide more than the recommended daily allowance (RDA) of water-soluble vitamins and micronutrients, with or without the addition of a kidney-friendly vitamin. The following is a comprehensive review of current literature on disorders of micronutrients in this population including those of water-soluble vitamins (vitamin C and vitamin B complexes) and trace elements (copper, selenium, and ...
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research

Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
ConclusionThese results demonstrate that aboveCUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum ofCUBN and benefiting our understanding of proteinuria and renal function. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - March 15, 2024 Category: Genetics & Stem Cells Authors: Huihui Yang, Lanfen He, Hongjian Gong, Chunhui Wan, Juanjuan Ding, Panli Liao, Xiaowen Wang Tags: ORIGINAL ARTICLE Source Type: research

“It was classed as a nonemergency”: Women's experiences of kidney disease and preconception decision‐making, family planning, and parenting in the United Kingdom during COVID‐19
ConclusionSome women in the UK with chronic kidney disease lost or missed their opportunity to have children during the pandemic. Future pandemic planners need to look more holistically and longer term at what is and is not classed as an emergency, both in how services are reconfigured and how people with chronic conditions are identified, communicated with, and treated. (Source: Perspectives on Sexual and Reproductive Health)
Source: Perspectives on Sexual and Reproductive Health - March 15, 2024 Category: Sexual Medicine Authors: Leah Mc Laughlin, Jane Noyes, Barbara Neukirchinger, Denitza Williams, Rhiannon Phillips, Sian Griffin Tags: ARTICLE Source Type: research

Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
CONCLUSION: These results demonstrate that above CUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum of CUBN and benefiting our understanding of proteinuria and renal function.PMID:38488435 | DOI:10.1002/mgg3.2353 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Huihui Yang Lanfen He Hongjian Gong Chunhui Wan Juanjuan Ding Panli Liao Xiaowen Wang Source Type: research

Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta-analysis
CONCLUSIONS: There is heterogeneity in the definition of CKD in pregnancy. Future studies should consider ways to standardise its definition and measurement in pregnancy.PMID:38488268 | DOI:10.1111/1471-0528.17807 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - March 15, 2024 Category: OBGYN Authors: Deepthika Jeyaraman Ben Walters Kate Bramham Richard Fish Mark Lambie Pens ée Wu Source Type: research

Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
CONCLUSION: These results demonstrate that above CUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum of CUBN and benefiting our understanding of proteinuria and renal function.PMID:38488435 | PMC:PMC10941600 | DOI:10.1002/mgg3.2353 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Huihui Yang Lanfen He Hongjian Gong Chunhui Wan Juanjuan Ding Panli Liao Xiaowen Wang Source Type: research

Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta-analysis
CONCLUSIONS: There is heterogeneity in the definition of CKD in pregnancy. Future studies should consider ways to standardise its definition and measurement in pregnancy.PMID:38488268 | DOI:10.1111/1471-0528.17807 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - March 15, 2024 Category: OBGYN Authors: Deepthika Jeyaraman Ben Walters Kate Bramham Richard Fish Mark Lambie Pens ée Wu Source Type: research