Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Mohammad Khani Amir Moradi Erfan Ghadirzadeh Seyed Pooria Salehi Mashhad Sari Tooba Akbari Source Type: research
Apparent Mineralocorticoid Excess in Israel: A Case Series and Literature Review
CONCLUSIONS: In this 11-year follow-up report of two Israeli families with AME, patients who presented early maintained long-term normal kidney function, while those who presented late progressed to ESKD. Nevertheless, despite early diagnosis and management, AME is commonly associated with serious complications of the disease or its treatment.PMID:38652803 | DOI:10.1093/ejendo/lvae049 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Asaf Lebel Efrat Ben Shalom Rozan Mokatern Raphael Halevy Yoav Zehavi Daniela Magen Source Type: research
Recent Update on Acute Kidney Injury-to-Chronic Kidney Disease Transition
Yonsei Med J. 2024 May;65(5):247-256. doi: 10.3349/ymj.2023.0306.ABSTRACTAcute kidney injury (AKI) is characterized by an abrupt decline of excretory kidney function. The incidence of AKI has increased in the past decades. Patients diagnosed with AKI often undergo diverse clinical trajectories, such as early or late recovery, relapses, and even a potential transition from AKI to chronic kidney disease (CKD). Although recent clinical studies have demonstrated a strong association between AKI and progression of CKD, our understanding of the complex relationship between AKI and CKD is still evolving. No cohort study has succe...
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Eun Sil Koh Sungjin Chung Source Type: research
Prophylactic Biosynthetic Retrorectus Mesh Placement During Stoma Reversal Reduces the Rate of Stoma Site Incisional Hernia
The objective of this study was to assess the use of prophylactic biosynthetic mesh at the time of stoma reversal on the overall SSIH rate.METHODS: This is an observational retrospective cohort study. A review of 101 consecutive patients who underwent PMR in the retrorectus plane from 2015 to 2020 was compared to 73 consecutive patients who underwent primary stoma closure without mesh from 2011 to 2014. The primary endpoint was the presence of SSIH on clinical examination or computed tomography after ostomy takedown.RESULTS: In total, 174 cases were analyzed with 101 patients in the treatment group (median follow-up 45.2 m...
Source: The Permanente journal - April 23, 2024 Category: General Medicine Authors: Brandon K Vu Jessica Lam Matthew J Sherman Michael S Tam Source Type: research
Calcium signaling induces partial EMT and renal fibrosis in a Wnt4 < sup > mCherry < /sup > knock-in mouse model
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167180. doi: 10.1016/j.bbadis.2024.167180. Online ahead of print.ABSTRACTThe renal tubular epithelial cells (TEC) have a strong capacity for repair after acute injury, but when this mechanism becomes uncontrollable, it leads to chronic kidney diseases (CKD). Indeed, in progress toward CKDs, the TECs may dedifferentiate, undergo epithelial-to-mesenchyme transition (EMT), and promote inflammation and fibrosis. Given the critical role of Wnt4 signaling in kidney ontogenesis, we addressed whether changes in this signaling are connected to renal inflammation and fibrosis by taking...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Florence Naillat Ganga Deshar Anni Hankkila Aleksandra Rak-Raszewska Abhishek Sharma Renata Prunskaite-Hyyrylainen Antti Railo Jingdong Shan Seppo J Vainio Source Type: research
Innovative insights: ITLN1 modulates renal injury in response to radiation
This study highlights the significant role of ITLN1 in regulating kidney injury, providing a novel target for future treatments of radiation-induced kidney injury.PMID:38652961 | DOI:10.1016/j.intimp.2024.111987 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Peng He Ying Guo Shize Wang Siyuan Bu Source Type: research
Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Mohammad Khani Amir Moradi Erfan Ghadirzadeh Seyed Pooria Salehi Mashhad Sari Tooba Akbari Source Type: research
Apparent Mineralocorticoid Excess in Israel: A Case Series and Literature Review
CONCLUSIONS: In this 11-year follow-up report of two Israeli families with AME, patients who presented early maintained long-term normal kidney function, while those who presented late progressed to ESKD. Nevertheless, despite early diagnosis and management, AME is commonly associated with serious complications of the disease or its treatment.PMID:38652803 | DOI:10.1093/ejendo/lvae049 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Asaf Lebel Efrat Ben Shalom Rozan Mokatern Raphael Halevy Yoav Zehavi Daniela Magen Source Type: research
Recent Update on Acute Kidney Injury-to-Chronic Kidney Disease Transition
Yonsei Med J. 2024 May;65(5):247-256. doi: 10.3349/ymj.2023.0306.ABSTRACTAcute kidney injury (AKI) is characterized by an abrupt decline of excretory kidney function. The incidence of AKI has increased in the past decades. Patients diagnosed with AKI often undergo diverse clinical trajectories, such as early or late recovery, relapses, and even a potential transition from AKI to chronic kidney disease (CKD). Although recent clinical studies have demonstrated a strong association between AKI and progression of CKD, our understanding of the complex relationship between AKI and CKD is still evolving. No cohort study has succe...
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Eun Sil Koh Sungjin Chung Source Type: research
Prophylactic Biosynthetic Retrorectus Mesh Placement During Stoma Reversal Reduces the Rate of Stoma Site Incisional Hernia
The objective of this study was to assess the use of prophylactic biosynthetic mesh at the time of stoma reversal on the overall SSIH rate.METHODS: This is an observational retrospective cohort study. A review of 101 consecutive patients who underwent PMR in the retrorectus plane from 2015 to 2020 was compared to 73 consecutive patients who underwent primary stoma closure without mesh from 2011 to 2014. The primary endpoint was the presence of SSIH on clinical examination or computed tomography after ostomy takedown.RESULTS: In total, 174 cases were analyzed with 101 patients in the treatment group (median follow-up 45.2 m...
Source: The Permanente journal - April 23, 2024 Category: General Medicine Authors: Brandon K Vu Jessica Lam Matthew J Sherman Michael S Tam Source Type: research
Calcium signaling induces partial EMT and renal fibrosis in a Wnt4 < sup > mCherry < /sup > knock-in mouse model
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167180. doi: 10.1016/j.bbadis.2024.167180. Online ahead of print.ABSTRACTThe renal tubular epithelial cells (TEC) have a strong capacity for repair after acute injury, but when this mechanism becomes uncontrollable, it leads to chronic kidney diseases (CKD). Indeed, in progress toward CKDs, the TECs may dedifferentiate, undergo epithelial-to-mesenchyme transition (EMT), and promote inflammation and fibrosis. Given the critical role of Wnt4 signaling in kidney ontogenesis, we addressed whether changes in this signaling are connected to renal inflammation and fibrosis by taking...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Florence Naillat Ganga Deshar Anni Hankkila Aleksandra Rak-Raszewska Abhishek Sharma Renata Prunskaite-Hyyrylainen Antti Railo Jingdong Shan Seppo J Vainio Source Type: research
Apparent Mineralocorticoid Excess in Israel: A Case Series and Literature Review
CONCLUSIONS: In this 11-year follow-up report of two Israeli families with AME, patients who presented early maintained long-term normal kidney function, while those who presented late progressed to ESKD. Nevertheless, despite early diagnosis and management, AME is commonly associated with serious complications of the disease or its treatment.PMID:38652803 | DOI:10.1093/ejendo/lvae049 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 23, 2024 Category: Endocrinology Authors: Asaf Lebel Efrat Ben Shalom Rozan Mokatern Raphael Halevy Yoav Zehavi Daniela Magen Source Type: research
Recent Update on Acute Kidney Injury-to-Chronic Kidney Disease Transition
Yonsei Med J. 2024 May;65(5):247-256. doi: 10.3349/ymj.2023.0306.ABSTRACTAcute kidney injury (AKI) is characterized by an abrupt decline of excretory kidney function. The incidence of AKI has increased in the past decades. Patients diagnosed with AKI often undergo diverse clinical trajectories, such as early or late recovery, relapses, and even a potential transition from AKI to chronic kidney disease (CKD). Although recent clinical studies have demonstrated a strong association between AKI and progression of CKD, our understanding of the complex relationship between AKI and CKD is still evolving. No cohort study has succe...
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Eun Sil Koh Sungjin Chung Source Type: research
Recent Update on Acute Kidney Injury-to-Chronic Kidney Disease Transition
Yonsei Med J. 2024 May;65(5):247-256. doi: 10.3349/ymj.2023.0306.ABSTRACTAcute kidney injury (AKI) is characterized by an abrupt decline of excretory kidney function. The incidence of AKI has increased in the past decades. Patients diagnosed with AKI often undergo diverse clinical trajectories, such as early or late recovery, relapses, and even a potential transition from AKI to chronic kidney disease (CKD). Although recent clinical studies have demonstrated a strong association between AKI and progression of CKD, our understanding of the complex relationship between AKI and CKD is still evolving. No cohort study has succe...
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Eun Sil Koh Sungjin Chung Source Type: research
Recent Update on Acute Kidney Injury-to-Chronic Kidney Disease Transition
Yonsei Med J. 2024 May;65(5):247-256. doi: 10.3349/ymj.2023.0306.ABSTRACTAcute kidney injury (AKI) is characterized by an abrupt decline of excretory kidney function. The incidence of AKI has increased in the past decades. Patients diagnosed with AKI often undergo diverse clinical trajectories, such as early or late recovery, relapses, and even a potential transition from AKI to chronic kidney disease (CKD). Although recent clinical studies have demonstrated a strong association between AKI and progression of CKD, our understanding of the complex relationship between AKI and CKD is still evolving. No cohort study has succe...
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Eun Sil Koh Sungjin Chung Source Type: research
