Roles of Type I and III Interferons in COVID-19
Yonsei Med J. 2021 May;62(5):381-390. doi: 10.3349/ymj.2021.62.5.381.ABSTRACTCoronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be i...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hojun Choi Eui Cheol Shin Source Type: research

Valsartan Dosage on Ventriculo-Vascular Coupling Index Dose-Dependency in Heart Failure Patients
Yonsei Med J. 2021 May;62(5):391-399. doi: 10.3349/ymj.2021.62.5.391.ABSTRACTPURPOSE: Heart failure (HF) poses significant morbidity and mortality. Recently, the ventriculo-vascular coupling index (VVI) was introduced as an independent prognostic factor reflective of the overall cardiovascular performance index in HF. We aimed to determine the effectiveness of force-titration of valsartan on VVI values in HF patients.MATERIALS AND METHODS: In this multicenter and prospective observational trial, the effect of valsartan was stratified according to dosages [non-ceiling dose (NCD) vs. ceiling dose (CD)] in HF patients with le...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Kyung Jin Ahn Jongwook Yu Albert Youngwoo Jang Dae Hyeok Kim Jun Kwan Wook Jin Chung Source Type: research

Higher Long-Term Mortality in Patients with Non-ST-Elevation Myocardial Infarction than ST-Elevation Myocardial Infarction after Discharge
This study aimed to compare mortality rates after discharge between the patients with non-ST-elevation myocardial infarction (NSTEMI) and those with ST-elevation myocardial infarction (STEMI), and identify each mortality risk factors in these two types of myocardial infarction.MATERIALS AND METHODS: Between 2011 and 2015, 13105 consecutive patients were enrolled in the Korea Acute Myocardial Infarction-National Institute of Health registry (KAMIR-NIH); 12271 patients with acute myocardial infarction met the inclusion criteria and were further stratified into the STEMI (n=5828) and NSTEMI (n=6443) groups. The occurrence of ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xiongyi Han Liyan Bai Myung Ho Jeong Joon Ho Ahn Dae Young Hyun Kyung Hoon Cho Min Chul Kim Doo Sun Sim Young Joon Hong Ju Han Kim Youngkeun Ahn Other KAMIR-NIH Registry Investigators Source Type: research

Optimal Timing of Radiotherapy after Incomplete Transarterial Chemoembolization for Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma
CONCLUSION: The optimal timing for administering RT after incomplete TACE is within 5 weeks. Early administration of RT is associated with better local control.PMID:33908211 | PMC:PMC8084693 | DOI:10.3349/ymj.2021.62.5.409 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hwa Kyung Byun Nalee Kim Jinsil Seong Source Type: research

Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea
Yonsei Med J. 2021 May;62(5):417-423. doi: 10.3349/ymj.2021.62.5.417.ABSTRACTPURPOSE: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population.MATERIALS AND METHODS: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Beong Ki Kim Sua Kim Chi Young Kim Yu Jin Kim Seung Heon Lee Jae Hyung Cha Je Hyeong Kim Source Type: research

Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
CONCLUSION: The clinicoserologic criteria based on MSA/MAA positivity could reflect more precise clinical features of IIM. Establishment of a laboratory system routinely available to screen for MSA/MAA status will be beneficial to provide precise diagnosis and proper management of IIM patients.PMID:33908213 | PMC:PMC8084694 | DOI:10.3349/ymj.2021.62.5.424 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Sang Wan Chung In Seol Yoo Jinhyun Kim Seong Wook Kang Mihye Kwon Chung Il Joung In Ah Choi Sung Hae Chang Mi Il Kang Seung Jae Hong Yeon Ah Lee Source Type: research

Clinical Features and Brain MRI Findings in Korean Patients with AGel Amyloidosis
CONCLUSION: Our study outlines the clinical manifestations of prominent bulbar palsy and early-onset cutis laxa in 13 Korean patients with AGel amyloidosis and confirms that AGel amyloidosis mainly affects the peripheral nervous system rather than the central nervous system.PMID:33908214 | PMC:PMC8084699 | DOI:10.3349/ymj.2021.62.5.431 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: E Nae Cheong Wooyul Paik Young Chul Choi Young Min Lim Hyunjin Kim Woo Hyun Shim Hyung Jun Park Source Type: research

Accuracy of 2D CT-Based Measurements of Rotational Alignment of the Femoral Component for Total Knee Arthroplasty
CONCLUSION: Mean errors in PCA and CTA values measured using three different methods on 2D-CT were not significantly different. However, PCA and CTA values measured on 2D-CT were approximately 1° smaller than their 3D values. Thus, we suggest that adding 1° to the mean PCA and CTA values obtained from a single plane of 2D-CT would provide values similar to those obtained from 3D reconstruction.PMID:33908215 | PMC:PMC8084701 | DOI:10.3349/ymj.2021.62.5.439 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Jun Young Park Hyuck Min Kwon Byung Woo Cho Woo Suk Lee Ick Hwan Yang Kwan Kyu Park Source Type: research

Association between Hearing Loss and Cognitive Disorder: A Nationwide Population-Based Study
CONCLUSION: Hearing loss has a significant effect on cognitive function in the Korean population. In our study, individuals with bilateral hearing loss showed poorer cognitive function than those with unilateral hearing loss.PMID:33908216 | PMC:PMC8084700 | DOI:10.3349/ymj.2021.62.5.446 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hyun Jin Lee Young Hoon Joo Kyung Do Han Kyoung Ho Park Source Type: research

miRNA-125b Signaling Ameliorates Liver Injury Against Obstructive Jaundice-Induced Excessive Fibrosis in Experimental Rats
CONCLUSION: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity, which slows the progression of injury-induced hepatic deterioration.PMID:33908217 | PMC:PMC8084692 | DOI:10.3349/ymj.2021.62.5.453 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xingyuan Zhang Fang Zhang Changxi Zhang Jie Li Source Type: research

MIR210HG Aggravates Sepsis-Induced Inflammatory Response of Proximal Tubular Epithelial Cell via the NF- κB Signaling Pathway
CONCLUSION: MIR210HG promotes sepsis-induced inflammatory response of HKC-8 cells by activating the NF-κB signaling pathway. This novel discovery may be helpful for the improvement of sepsis-induced AKI.PMID:33908218 | PMC:PMC8084703 | DOI:10.3349/ymj.2021.62.5.461 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Shuai Deng Bin Gu Zheng Yu Zhen Shen Houwei Ren Source Type: research

Therapeutic Lymphatic Embolization in Pediatric Primary Intestinal Lymphangiectasia
Yonsei Med J. 2021 May;62(5):470-473. doi: 10.3349/ymj.2021.62.5.470.ABSTRACTPrimary intestinal lymphangiectasia (IL) can cause leakage of lymphatic fluids into the gastrointestinal tract, eventually leading to protein-losing enteropathy. A 15-year-old male patient, whose disease began at the age of 8 years, recently felt worsening general weakness. After diagnosing abnormal lymphatic lesions in the duodenum through endoscopy with biopsy and contrast-enhanced magnetic resonance lymphangiography, glue embolization of the leaking duodenal lymphatic channel was successfully performed. This procedure is typically reserved for ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Yiyoung Kwon Eun Sil Kim Yon Ho Choe Dongho Hyun Mi Jin Kim Source Type: research

Roles of Type I and III Interferons in COVID-19
Yonsei Med J. 2021 May;62(5):381-390. doi: 10.3349/ymj.2021.62.5.381.ABSTRACTCoronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be i...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hojun Choi Eui Cheol Shin Source Type: research

Valsartan Dosage on Ventriculo-Vascular Coupling Index Dose-Dependency in Heart Failure Patients
Yonsei Med J. 2021 May;62(5):391-399. doi: 10.3349/ymj.2021.62.5.391.ABSTRACTPURPOSE: Heart failure (HF) poses significant morbidity and mortality. Recently, the ventriculo-vascular coupling index (VVI) was introduced as an independent prognostic factor reflective of the overall cardiovascular performance index in HF. We aimed to determine the effectiveness of force-titration of valsartan on VVI values in HF patients.MATERIALS AND METHODS: In this multicenter and prospective observational trial, the effect of valsartan was stratified according to dosages [non-ceiling dose (NCD) vs. ceiling dose (CD)] in HF patients with le...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Kyung Jin Ahn Jongwook Yu Albert Youngwoo Jang Dae Hyeok Kim Jun Kwan Wook Jin Chung Source Type: research

Higher Long-Term Mortality in Patients with Non-ST-Elevation Myocardial Infarction than ST-Elevation Myocardial Infarction after Discharge
This study aimed to compare mortality rates after discharge between the patients with non-ST-elevation myocardial infarction (NSTEMI) and those with ST-elevation myocardial infarction (STEMI), and identify each mortality risk factors in these two types of myocardial infarction.MATERIALS AND METHODS: Between 2011 and 2015, 13105 consecutive patients were enrolled in the Korea Acute Myocardial Infarction-National Institute of Health registry (KAMIR-NIH); 12271 patients with acute myocardial infarction met the inclusion criteria and were further stratified into the STEMI (n=5828) and NSTEMI (n=6443) groups. The occurrence of ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xiongyi Han Liyan Bai Myung Ho Jeong Joon Ho Ahn Dae Young Hyun Kyung Hoon Cho Min Chul Kim Doo Sun Sim Young Joon Hong Ju Han Kim Youngkeun Ahn Other KAMIR-NIH Registry Investigators Source Type: research

Optimal Timing of Radiotherapy after Incomplete Transarterial Chemoembolization for Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma
CONCLUSION: The optimal timing for administering RT after incomplete TACE is within 5 weeks. Early administration of RT is associated with better local control.PMID:33908211 | PMC:PMC8084693 | DOI:10.3349/ymj.2021.62.5.409 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hwa Kyung Byun Nalee Kim Jinsil Seong Source Type: research

Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea
Yonsei Med J. 2021 May;62(5):417-423. doi: 10.3349/ymj.2021.62.5.417.ABSTRACTPURPOSE: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population.MATERIALS AND METHODS: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Beong Ki Kim Sua Kim Chi Young Kim Yu Jin Kim Seung Heon Lee Jae Hyung Cha Je Hyeong Kim Source Type: research

Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
CONCLUSION: The clinicoserologic criteria based on MSA/MAA positivity could reflect more precise clinical features of IIM. Establishment of a laboratory system routinely available to screen for MSA/MAA status will be beneficial to provide precise diagnosis and proper management of IIM patients.PMID:33908213 | PMC:PMC8084694 | DOI:10.3349/ymj.2021.62.5.424 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Sang Wan Chung In Seol Yoo Jinhyun Kim Seong Wook Kang Mihye Kwon Chung Il Joung In Ah Choi Sung Hae Chang Mi Il Kang Seung Jae Hong Yeon Ah Lee Source Type: research

Clinical Features and Brain MRI Findings in Korean Patients with AGel Amyloidosis
CONCLUSION: Our study outlines the clinical manifestations of prominent bulbar palsy and early-onset cutis laxa in 13 Korean patients with AGel amyloidosis and confirms that AGel amyloidosis mainly affects the peripheral nervous system rather than the central nervous system.PMID:33908214 | PMC:PMC8084699 | DOI:10.3349/ymj.2021.62.5.431 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: E Nae Cheong Wooyul Paik Young Chul Choi Young Min Lim Hyunjin Kim Woo Hyun Shim Hyung Jun Park Source Type: research

Accuracy of 2D CT-Based Measurements of Rotational Alignment of the Femoral Component for Total Knee Arthroplasty
CONCLUSION: Mean errors in PCA and CTA values measured using three different methods on 2D-CT were not significantly different. However, PCA and CTA values measured on 2D-CT were approximately 1° smaller than their 3D values. Thus, we suggest that adding 1° to the mean PCA and CTA values obtained from a single plane of 2D-CT would provide values similar to those obtained from 3D reconstruction.PMID:33908215 | PMC:PMC8084701 | DOI:10.3349/ymj.2021.62.5.439 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Jun Young Park Hyuck Min Kwon Byung Woo Cho Woo Suk Lee Ick Hwan Yang Kwan Kyu Park Source Type: research

Association between Hearing Loss and Cognitive Disorder: A Nationwide Population-Based Study
CONCLUSION: Hearing loss has a significant effect on cognitive function in the Korean population. In our study, individuals with bilateral hearing loss showed poorer cognitive function than those with unilateral hearing loss.PMID:33908216 | PMC:PMC8084700 | DOI:10.3349/ymj.2021.62.5.446 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hyun Jin Lee Young Hoon Joo Kyung Do Han Kyoung Ho Park Source Type: research

miRNA-125b Signaling Ameliorates Liver Injury Against Obstructive Jaundice-Induced Excessive Fibrosis in Experimental Rats
CONCLUSION: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity, which slows the progression of injury-induced hepatic deterioration.PMID:33908217 | PMC:PMC8084692 | DOI:10.3349/ymj.2021.62.5.453 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xingyuan Zhang Fang Zhang Changxi Zhang Jie Li Source Type: research

MIR210HG Aggravates Sepsis-Induced Inflammatory Response of Proximal Tubular Epithelial Cell via the NF- κB Signaling Pathway
CONCLUSION: MIR210HG promotes sepsis-induced inflammatory response of HKC-8 cells by activating the NF-κB signaling pathway. This novel discovery may be helpful for the improvement of sepsis-induced AKI.PMID:33908218 | PMC:PMC8084703 | DOI:10.3349/ymj.2021.62.5.461 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Shuai Deng Bin Gu Zheng Yu Zhen Shen Houwei Ren Source Type: research

Therapeutic Lymphatic Embolization in Pediatric Primary Intestinal Lymphangiectasia
Yonsei Med J. 2021 May;62(5):470-473. doi: 10.3349/ymj.2021.62.5.470.ABSTRACTPrimary intestinal lymphangiectasia (IL) can cause leakage of lymphatic fluids into the gastrointestinal tract, eventually leading to protein-losing enteropathy. A 15-year-old male patient, whose disease began at the age of 8 years, recently felt worsening general weakness. After diagnosing abnormal lymphatic lesions in the duodenum through endoscopy with biopsy and contrast-enhanced magnetic resonance lymphangiography, glue embolization of the leaking duodenal lymphatic channel was successfully performed. This procedure is typically reserved for ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Yiyoung Kwon Eun Sil Kim Yon Ho Choe Dongho Hyun Mi Jin Kim Source Type: research

Roles of Type I and III Interferons in COVID-19
Yonsei Med J. 2021 May;62(5):381-390. doi: 10.3349/ymj.2021.62.5.381.ABSTRACTCoronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be i...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hojun Choi Eui Cheol Shin Source Type: research

Valsartan Dosage on Ventriculo-Vascular Coupling Index Dose-Dependency in Heart Failure Patients
Yonsei Med J. 2021 May;62(5):391-399. doi: 10.3349/ymj.2021.62.5.391.ABSTRACTPURPOSE: Heart failure (HF) poses significant morbidity and mortality. Recently, the ventriculo-vascular coupling index (VVI) was introduced as an independent prognostic factor reflective of the overall cardiovascular performance index in HF. We aimed to determine the effectiveness of force-titration of valsartan on VVI values in HF patients.MATERIALS AND METHODS: In this multicenter and prospective observational trial, the effect of valsartan was stratified according to dosages [non-ceiling dose (NCD) vs. ceiling dose (CD)] in HF patients with le...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Kyung Jin Ahn Jongwook Yu Albert Youngwoo Jang Dae Hyeok Kim Jun Kwan Wook Jin Chung Source Type: research

Higher Long-Term Mortality in Patients with Non-ST-Elevation Myocardial Infarction than ST-Elevation Myocardial Infarction after Discharge
This study aimed to compare mortality rates after discharge between the patients with non-ST-elevation myocardial infarction (NSTEMI) and those with ST-elevation myocardial infarction (STEMI), and identify each mortality risk factors in these two types of myocardial infarction.MATERIALS AND METHODS: Between 2011 and 2015, 13105 consecutive patients were enrolled in the Korea Acute Myocardial Infarction-National Institute of Health registry (KAMIR-NIH); 12271 patients with acute myocardial infarction met the inclusion criteria and were further stratified into the STEMI (n=5828) and NSTEMI (n=6443) groups. The occurrence of ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xiongyi Han Liyan Bai Myung Ho Jeong Joon Ho Ahn Dae Young Hyun Kyung Hoon Cho Min Chul Kim Doo Sun Sim Young Joon Hong Ju Han Kim Youngkeun Ahn Other KAMIR-NIH Registry Investigators Source Type: research

Optimal Timing of Radiotherapy after Incomplete Transarterial Chemoembolization for Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma
CONCLUSION: The optimal timing for administering RT after incomplete TACE is within 5 weeks. Early administration of RT is associated with better local control.PMID:33908211 | PMC:PMC8084693 | DOI:10.3349/ymj.2021.62.5.409 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hwa Kyung Byun Nalee Kim Jinsil Seong Source Type: research

Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea
Yonsei Med J. 2021 May;62(5):417-423. doi: 10.3349/ymj.2021.62.5.417.ABSTRACTPURPOSE: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population.MATERIALS AND METHODS: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Beong Ki Kim Sua Kim Chi Young Kim Yu Jin Kim Seung Heon Lee Jae Hyung Cha Je Hyeong Kim Source Type: research

Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
CONCLUSION: The clinicoserologic criteria based on MSA/MAA positivity could reflect more precise clinical features of IIM. Establishment of a laboratory system routinely available to screen for MSA/MAA status will be beneficial to provide precise diagnosis and proper management of IIM patients.PMID:33908213 | PMC:PMC8084694 | DOI:10.3349/ymj.2021.62.5.424 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Sang Wan Chung In Seol Yoo Jinhyun Kim Seong Wook Kang Mihye Kwon Chung Il Joung In Ah Choi Sung Hae Chang Mi Il Kang Seung Jae Hong Yeon Ah Lee Source Type: research

Clinical Features and Brain MRI Findings in Korean Patients with AGel Amyloidosis
CONCLUSION: Our study outlines the clinical manifestations of prominent bulbar palsy and early-onset cutis laxa in 13 Korean patients with AGel amyloidosis and confirms that AGel amyloidosis mainly affects the peripheral nervous system rather than the central nervous system.PMID:33908214 | PMC:PMC8084699 | DOI:10.3349/ymj.2021.62.5.431 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: E Nae Cheong Wooyul Paik Young Chul Choi Young Min Lim Hyunjin Kim Woo Hyun Shim Hyung Jun Park Source Type: research

Accuracy of 2D CT-Based Measurements of Rotational Alignment of the Femoral Component for Total Knee Arthroplasty
CONCLUSION: Mean errors in PCA and CTA values measured using three different methods on 2D-CT were not significantly different. However, PCA and CTA values measured on 2D-CT were approximately 1° smaller than their 3D values. Thus, we suggest that adding 1° to the mean PCA and CTA values obtained from a single plane of 2D-CT would provide values similar to those obtained from 3D reconstruction.PMID:33908215 | PMC:PMC8084701 | DOI:10.3349/ymj.2021.62.5.439 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Jun Young Park Hyuck Min Kwon Byung Woo Cho Woo Suk Lee Ick Hwan Yang Kwan Kyu Park Source Type: research

Association between Hearing Loss and Cognitive Disorder: A Nationwide Population-Based Study
CONCLUSION: Hearing loss has a significant effect on cognitive function in the Korean population. In our study, individuals with bilateral hearing loss showed poorer cognitive function than those with unilateral hearing loss.PMID:33908216 | PMC:PMC8084700 | DOI:10.3349/ymj.2021.62.5.446 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hyun Jin Lee Young Hoon Joo Kyung Do Han Kyoung Ho Park Source Type: research

miRNA-125b Signaling Ameliorates Liver Injury Against Obstructive Jaundice-Induced Excessive Fibrosis in Experimental Rats
CONCLUSION: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity, which slows the progression of injury-induced hepatic deterioration.PMID:33908217 | PMC:PMC8084692 | DOI:10.3349/ymj.2021.62.5.453 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xingyuan Zhang Fang Zhang Changxi Zhang Jie Li Source Type: research

MIR210HG Aggravates Sepsis-Induced Inflammatory Response of Proximal Tubular Epithelial Cell via the NF- κB Signaling Pathway
CONCLUSION: MIR210HG promotes sepsis-induced inflammatory response of HKC-8 cells by activating the NF-κB signaling pathway. This novel discovery may be helpful for the improvement of sepsis-induced AKI.PMID:33908218 | PMC:PMC8084703 | DOI:10.3349/ymj.2021.62.5.461 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Shuai Deng Bin Gu Zheng Yu Zhen Shen Houwei Ren Source Type: research

Therapeutic Lymphatic Embolization in Pediatric Primary Intestinal Lymphangiectasia
Yonsei Med J. 2021 May;62(5):470-473. doi: 10.3349/ymj.2021.62.5.470.ABSTRACTPrimary intestinal lymphangiectasia (IL) can cause leakage of lymphatic fluids into the gastrointestinal tract, eventually leading to protein-losing enteropathy. A 15-year-old male patient, whose disease began at the age of 8 years, recently felt worsening general weakness. After diagnosing abnormal lymphatic lesions in the duodenum through endoscopy with biopsy and contrast-enhanced magnetic resonance lymphangiography, glue embolization of the leaking duodenal lymphatic channel was successfully performed. This procedure is typically reserved for ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Yiyoung Kwon Eun Sil Kim Yon Ho Choe Dongho Hyun Mi Jin Kim Source Type: research

Roles of Type I and III Interferons in COVID-19
Yonsei Med J. 2021 May;62(5):381-390. doi: 10.3349/ymj.2021.62.5.381.ABSTRACTCoronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be i...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hojun Choi Eui Cheol Shin Source Type: research

Valsartan Dosage on Ventriculo-Vascular Coupling Index Dose-Dependency in Heart Failure Patients
Yonsei Med J. 2021 May;62(5):391-399. doi: 10.3349/ymj.2021.62.5.391.ABSTRACTPURPOSE: Heart failure (HF) poses significant morbidity and mortality. Recently, the ventriculo-vascular coupling index (VVI) was introduced as an independent prognostic factor reflective of the overall cardiovascular performance index in HF. We aimed to determine the effectiveness of force-titration of valsartan on VVI values in HF patients.MATERIALS AND METHODS: In this multicenter and prospective observational trial, the effect of valsartan was stratified according to dosages [non-ceiling dose (NCD) vs. ceiling dose (CD)] in HF patients with le...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Kyung Jin Ahn Jongwook Yu Albert Youngwoo Jang Dae Hyeok Kim Jun Kwan Wook Jin Chung Source Type: research

Higher Long-Term Mortality in Patients with Non-ST-Elevation Myocardial Infarction than ST-Elevation Myocardial Infarction after Discharge
This study aimed to compare mortality rates after discharge between the patients with non-ST-elevation myocardial infarction (NSTEMI) and those with ST-elevation myocardial infarction (STEMI), and identify each mortality risk factors in these two types of myocardial infarction.MATERIALS AND METHODS: Between 2011 and 2015, 13105 consecutive patients were enrolled in the Korea Acute Myocardial Infarction-National Institute of Health registry (KAMIR-NIH); 12271 patients with acute myocardial infarction met the inclusion criteria and were further stratified into the STEMI (n=5828) and NSTEMI (n=6443) groups. The occurrence of ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xiongyi Han Liyan Bai Myung Ho Jeong Joon Ho Ahn Dae Young Hyun Kyung Hoon Cho Min Chul Kim Doo Sun Sim Young Joon Hong Ju Han Kim Youngkeun Ahn Other KAMIR-NIH Registry Investigators Source Type: research

Optimal Timing of Radiotherapy after Incomplete Transarterial Chemoembolization for Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma
CONCLUSION: The optimal timing for administering RT after incomplete TACE is within 5 weeks. Early administration of RT is associated with better local control.PMID:33908211 | PMC:PMC8084693 | DOI:10.3349/ymj.2021.62.5.409 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hwa Kyung Byun Nalee Kim Jinsil Seong Source Type: research

Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea
Yonsei Med J. 2021 May;62(5):417-423. doi: 10.3349/ymj.2021.62.5.417.ABSTRACTPURPOSE: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population.MATERIALS AND METHODS: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Beong Ki Kim Sua Kim Chi Young Kim Yu Jin Kim Seung Heon Lee Jae Hyung Cha Je Hyeong Kim Source Type: research

Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
CONCLUSION: The clinicoserologic criteria based on MSA/MAA positivity could reflect more precise clinical features of IIM. Establishment of a laboratory system routinely available to screen for MSA/MAA status will be beneficial to provide precise diagnosis and proper management of IIM patients.PMID:33908213 | PMC:PMC8084694 | DOI:10.3349/ymj.2021.62.5.424 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Sang Wan Chung In Seol Yoo Jinhyun Kim Seong Wook Kang Mihye Kwon Chung Il Joung In Ah Choi Sung Hae Chang Mi Il Kang Seung Jae Hong Yeon Ah Lee Source Type: research

Clinical Features and Brain MRI Findings in Korean Patients with AGel Amyloidosis
CONCLUSION: Our study outlines the clinical manifestations of prominent bulbar palsy and early-onset cutis laxa in 13 Korean patients with AGel amyloidosis and confirms that AGel amyloidosis mainly affects the peripheral nervous system rather than the central nervous system.PMID:33908214 | PMC:PMC8084699 | DOI:10.3349/ymj.2021.62.5.431 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: E Nae Cheong Wooyul Paik Young Chul Choi Young Min Lim Hyunjin Kim Woo Hyun Shim Hyung Jun Park Source Type: research

Accuracy of 2D CT-Based Measurements of Rotational Alignment of the Femoral Component for Total Knee Arthroplasty
CONCLUSION: Mean errors in PCA and CTA values measured using three different methods on 2D-CT were not significantly different. However, PCA and CTA values measured on 2D-CT were approximately 1° smaller than their 3D values. Thus, we suggest that adding 1° to the mean PCA and CTA values obtained from a single plane of 2D-CT would provide values similar to those obtained from 3D reconstruction.PMID:33908215 | PMC:PMC8084701 | DOI:10.3349/ymj.2021.62.5.439 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Jun Young Park Hyuck Min Kwon Byung Woo Cho Woo Suk Lee Ick Hwan Yang Kwan Kyu Park Source Type: research

Association between Hearing Loss and Cognitive Disorder: A Nationwide Population-Based Study
CONCLUSION: Hearing loss has a significant effect on cognitive function in the Korean population. In our study, individuals with bilateral hearing loss showed poorer cognitive function than those with unilateral hearing loss.PMID:33908216 | PMC:PMC8084700 | DOI:10.3349/ymj.2021.62.5.446 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hyun Jin Lee Young Hoon Joo Kyung Do Han Kyoung Ho Park Source Type: research

miRNA-125b Signaling Ameliorates Liver Injury Against Obstructive Jaundice-Induced Excessive Fibrosis in Experimental Rats
CONCLUSION: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity, which slows the progression of injury-induced hepatic deterioration.PMID:33908217 | PMC:PMC8084692 | DOI:10.3349/ymj.2021.62.5.453 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Xingyuan Zhang Fang Zhang Changxi Zhang Jie Li Source Type: research

MIR210HG Aggravates Sepsis-Induced Inflammatory Response of Proximal Tubular Epithelial Cell via the NF- κB Signaling Pathway
CONCLUSION: MIR210HG promotes sepsis-induced inflammatory response of HKC-8 cells by activating the NF-κB signaling pathway. This novel discovery may be helpful for the improvement of sepsis-induced AKI.PMID:33908218 | PMC:PMC8084703 | DOI:10.3349/ymj.2021.62.5.461 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Shuai Deng Bin Gu Zheng Yu Zhen Shen Houwei Ren Source Type: research

Therapeutic Lymphatic Embolization in Pediatric Primary Intestinal Lymphangiectasia
Yonsei Med J. 2021 May;62(5):470-473. doi: 10.3349/ymj.2021.62.5.470.ABSTRACTPrimary intestinal lymphangiectasia (IL) can cause leakage of lymphatic fluids into the gastrointestinal tract, eventually leading to protein-losing enteropathy. A 15-year-old male patient, whose disease began at the age of 8 years, recently felt worsening general weakness. After diagnosing abnormal lymphatic lesions in the duodenum through endoscopy with biopsy and contrast-enhanced magnetic resonance lymphangiography, glue embolization of the leaking duodenal lymphatic channel was successfully performed. This procedure is typically reserved for ...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Yiyoung Kwon Eun Sil Kim Yon Ho Choe Dongho Hyun Mi Jin Kim Source Type: research

Roles of Type I and III Interferons in COVID-19
Yonsei Med J. 2021 May;62(5):381-390. doi: 10.3349/ymj.2021.62.5.381.ABSTRACTCoronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be i...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Hojun Choi Eui Cheol Shin Source Type: research

Valsartan Dosage on Ventriculo-Vascular Coupling Index Dose-Dependency in Heart Failure Patients
Yonsei Med J. 2021 May;62(5):391-399. doi: 10.3349/ymj.2021.62.5.391.ABSTRACTPURPOSE: Heart failure (HF) poses significant morbidity and mortality. Recently, the ventriculo-vascular coupling index (VVI) was introduced as an independent prognostic factor reflective of the overall cardiovascular performance index in HF. We aimed to determine the effectiveness of force-titration of valsartan on VVI values in HF patients.MATERIALS AND METHODS: In this multicenter and prospective observational trial, the effect of valsartan was stratified according to dosages [non-ceiling dose (NCD) vs. ceiling dose (CD)] in HF patients with le...
Source: Yonsei Medical Journal - April 28, 2021 Category: Universities & Medical Training Authors: Kyung Jin Ahn Jongwook Yu Albert Youngwoo Jang Dae Hyeok Kim Jun Kwan Wook Jin Chung Source Type: research