Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma.
Abstract Various molecular targeted therapies and diagnostic modalities have been developed for the treatment of hepatocellular carcinoma (HCC); however, HCC still remains a difficult malignancy to cure. Recently, the focus has shifted to cancer metabolism for the diagnosis and treatment of various cancers, including HCC. In addition to conventional diagnostics, the measurement of enhanced tumor cell metabolism using F-18 fluorodeoxyglucose (18F-FDG) for increased glycolysis or C-11 acetate for fatty acid synthesis by positron emission tomography/computed tomography (PET/CT) is well established for clinical manage...
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Lee M, Ko H, Yun M Tags: Yonsei Med J Source Type: research

Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches.
Abstract Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC stem-like cells (GCSCs), with unlimited self-renewal, differentiation, and tumor-regenerating capacities, contribute significantly to the refractory features of GC and have gained increasing attention for their role in GC drug resistance, relapse, and metastasis. Therapies targeting GCSCs seem to be one of the most promising methods to improve the outcomes of GC patients. Extensive investigations have attempted to outline the regulatory mechanisms in GCSCs and to develop GCSCs-targeting therapies with which to diminish G...
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Fu Y, Du P, Zhao J, Hu C, Qin Y, Huang G Tags: Yonsei Med J Source Type: research

PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKC α/NF-κB Pathway.
CONCLUSION: PLCE1 activated NF-κB signaling by up-regulating PKCα, which could promote invasion and migration of esophageal cancer cells. PMID: 30450849 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Li Y, Luan C Tags: Yonsei Med J Source Type: research

RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer.
CONCLUSION: The present study found RPS15a expression to be higher in gastric tumors and its silencing in gastric cancer cells to inhibit the proliferation, growth, and migration thereof. Accordingly, RPS15a may be considered as a potential therapeutic target in gastric cancer. PMID: 30450850 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Shi D, Liu J Tags: Yonsei Med J Source Type: research

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats.
CONCLUSION: Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST in the hypothalamus. Further studies are needed to overcome the observed desensitization to GHS. PMID: 30450851 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS Tags: Yonsei Med J Source Type: research

Depletion of MicroRNA-373 Represses the Replication of Hepatitis C Virus via Activation of Type 1 Interferon Response by Targeting IRF5.
CONCLUSION: miR-373 abrogation reduced HCV replication via activation of type 1 IFN responses by targeting IRF5 in JFH1-infected Huh 7.5 cells, suggesting a promising therapeutic for treating HCV infection. PMID: 30450852 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Gong W, Guo X, Zhang Y Tags: Yonsei Med J Source Type: research

Ophthalmoplegia in Mitochondrial Disease.
Abstract PURPOSE: To evaluate the classification, diagnosis, and natural course of ophthalmoplegia associated with mitochondrial disease. MATERIALS AND METHODS: Among 372 patients with mitochondrial disease who visited our hospital between January 2006 and January 2016, 21 patients with ophthalmoplegia were retrospectively identified. Inclusion criteria included onset before 20 years of age, pigmentary retinopathy, and cardiac involvement. The 16 patients who were finally included in the study were divided into three groups according to disease type: Kearns-Sayre syndrome (KSS), KSS-like, and chronic progress...
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Lee SJ, Na JH, Han J, Lee YM Tags: Yonsei Med J Source Type: research

The Brain Donation Program in South Korea.
CONCLUSION: The clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea. PMID: 30450854 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Kim Y, Suh YL, Kim SJ, Bae MH, Kim JB, Kim Y, Choi KC, Huh GY, Kim EJ, Lee JS, Kang HW, Shim SM, Lim HJ, Koh YH, Kim BC, Lee KH, Lee MC, Lee HW, Lim TS, Seeley WW, Kim HJ, Na DL, Lee KH, Seo SW Tags: Yonsei Med J Source Type: research

miR-34a Inhibitor May Effectively Protect against Sevoflurane-Induced Hippocampal Apoptosis through the Wnt/ β-Catenin Pathway by Targeting Wnt1.
CONCLUSION: miR-34a inhibitor may effectively protect against sevoflurane-induced hippocampal apoptosis via activation of the Wnt/β-catenin pathway by targeting Wnt1. PMID: 30450855 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Zhao X, Sun Y, Ding Y, Zhang J, Li K Tags: Yonsei Med J Source Type: research

Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma.
Abstract PURPOSE: Toluene diisocyanate (TDI) is a leading cause of occupational asthma (OA). Periostin is a matricellular protein implicated in type 2 immunity-driven asthma. Its pathogenic role in TDI-OA has not been completely elucidated. The present study was performed to investigate the role of periostin in TDI-OA. MATERIALS AND METHODS: Serum periostin levels were measured in subjects with TDI-OA, asymptomatic TDI-exposure controls (AECs), non-occupational asthmatics (NAs), and unexposed normal controls (NCs). To understand the mechanism by which TDI induces periostin production, primary small airway epi...
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Lee JH, Kim SH, Choi Y, Trinh HKT, Yang EM, Ban GY, Shin YS, Ye YM, Izuhara K, Park HS Tags: Yonsei Med J Source Type: research

German Cockroach Extract Induces Matrix Metalloproteinase-1 Expression, Leading to Tight Junction Disruption in Human Airway Epithelial Cells.
CONCLUSION: GCE treatment increases MMP1 expression, leading to tight junction disruption, which is transcriptionally regulated and influenced by the ERK/MAPK pathway in airway epithelial cells. These findings may contribute to developing novel therapeutic strategies for airway diseases. PMID: 30450857 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Lee KE, Jee HM, Hong JY, Kim MN, Oh MS, Kim YS, Kim KW, Kim KE, Sohn MH Tags: Yonsei Med J Source Type: research

Single Ventilation during Cardiopulmonary Resuscitation Results in Better Neurological Outcomes in a Porcine Model of Cardiac Arrest.
In this study, we compared the short-term outcomes among CC, CV2, and 30:1 CV ratio (CV1). MATERIALS AND METHODS: In total, 42 pigs were randomly assigned to CC, CV1, or CV2 groups. After induction of ventricular fibrillation (VF), we observed pigs for 2 minutes without any intervention. Thereafter, BLS was started according to the assigned method and performed for 8 minutes. Defibrillation was performed after BLS and repeated every 2 minutes, followed by rhythm analysis. Advanced cardiac life support, including continuous chest compression with ventilation every 6 seconds and intravenous injection of 1 mg epinephrine...
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Kim YW, Kim HI, Hwang SO, Kim YS, An GJ, Cha KC Tags: Yonsei Med J Source Type: research

Concerns for Older Adult Patients with Acute Hip Fracture.
CONCLUSION: Older adult patients reported fear of falling from bed and re-fracture as primary concerns. To overcome these concerns, fracture liaison services to prevent re-fracture should be introduced and enforced. PMID: 30450859 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Yoo JI, Lee YK, Koo KH, Park YJ, Ha YC Tags: Yonsei Med J Source Type: research

Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.
This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART). MATERIALS AND METHODS: From a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertension at baseline were analyzed. The use of ART was treated as a time-varying covariate measured as a daily unit. Incidence rate of hypertension was calculated, and Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) with 95% confidence interval (CI) of incident hypertension overall and among subgroups. RESULTS: From the 6493 participants, 24...
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Kim J, Bang JH, Shin JY, Yang BR, Lee J, Park BJ Tags: Yonsei Med J Source Type: research

Identification of Anti-Gerbich Antibody in an Emirati Marrow Hematopoietic Progenitor Cell Donor with Fy(a-b-) Phenotype.
In this study, we report a case of anti-Gerbich (Ge) alloantibody to a high-prevalence Ge antigen in a donor with Fy(a-b-) phenotype. The alloantibody was detected in an Emirati boy who was admitted to a Korean tertiary hospital for marrow hematopoietic progenitor cell donation. He did not have a history of transfusion. His blood type was A, RhD+, and findings from the antibody screening and identification test showed 2+ reactivity in all panel cells except autologous cells. We concluded that it would be very difficult to find compatible blood components for the donor and requested further tests from external laboratories....
Source: Yonsei Medical Journal - November 21, 2018 Category: Universities & Medical Training Authors: Choi SJ, Lee E, Kim S, Lyu CJ, Kim HO Tags: Yonsei Med J Source Type: research

Indoor Radon and Lung Cancer: National Radon Action Plans Are Urgently Required.
PMID: 30328314 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Nam HS, Ryu JS Tags: Yonsei Med J Source Type: research

Bioactive Compounds for the Treatment of Renal Disease.
Abstract Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and mult...
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Cho KS, Ko IK, Yoo JJ Tags: Yonsei Med J Source Type: research

Socioeconomic Inequalities in Cervical and Breast Cancer Screening among Women in Korea, 2005-2015.
CONCLUSION: Our study identified significant inequalities among socioeconomically deprived women in cervical and breast cancer screening in Korea. Especially, income-related inequalities were greater than education-related inequalities, and these were constant from 2005 to 2015 for both cervical and breast cancer screening. PMID: 30328316 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Choi E, Lee YY, Suh M, Lee EY, Mai TTX, Ki M, Oh JK, Cho H, Park B, Jun JK, Kim Y, Choi KS Tags: Yonsei Med J Source Type: research

Socioeconomic Inequalities in Colorectal Cancer Screening in Korea, 2005-2015: After the Introduction of the National Cancer Screening Program.
CONCLUSION: Education inequalities in CRC screening among men and women aged 50 to 74 years were observed in Korea. No apparent pattern, however, was found for income inequalities. Further studies are needed to thoroughly outline socio-economic inequalities in CRC screening. PMID: 30328317 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Mai TTX, Lee YY, Suh M, Choi E, Lee EY, Ki M, Cho H, Park B, Jun JK, Kim Y, Oh JK, Choi KS Tags: Yonsei Med J Source Type: research

Heat Shock Factor 1 Predicts Poor Prognosis of Gastric Cancer.
CONCLUSION: HSF1 may be closely associated with the proliferation and motility of gastric cancer cells and poor prognosis of patients with gastric cancer. Accordingly, HSF1 could serve as a prognostic marker for gastric cancer. PMID: 30328318 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Kim SJ, Lee SC, Kang HG, Gim J, Lee KH, Lee SH, Chun KH Tags: Yonsei Med J Source Type: research

Efficacy of Postoperative Radiotherapy Using Modern Techniques in Patients with Retroperitoneal Soft Tissue Sarcoma.
Abstract PURPOSE: Local recurrence is the most common cause of failure in retroperitoneal soft tissue sarcoma patients after surgical resection. Postoperative radiotherapy (PORT) is infrequently used due to its high complication risk. We investigated the efficacy of PORT using modern techniques in patients with retroperitoneal soft tissue sarcoma. MATERIALS AND METHODS: Eighty patients, who underwent surgical resection for non-metastatic primary retroperitoneal soft tissue sarcoma at the Yonsei Cancer Center between 1994 and 2015, were retrospectively reviewed. Thirty-eight (47.5%) patients received PORT: thr...
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Kim HJ, Koom WS, Cho J, Kim HS, Suh CO Tags: Yonsei Med J Source Type: research

Impact of Insulin Resistance on Acetylcholine-Induced Coronary Artery Spasm in Non-Diabetic Patients.
Abstract PURPOSE: Coronary artery spasm (CAS) and diabetes mellitus (DM) are implicated in endothelial dysfunction, and insulin resistance (IR) is a major etiological cause of type 2 DM. However, the association between CAS and IR in non-diabetic individuals has not been elucidated. The aim of the present study was to evaluate the impact of IR on CAS in patients without DM. MATERIALS AND METHODS: A total of 330 eligible patients without DM and coronary artery disease who underwent acetylcholine (Ach) provocation test were enrolled in this study. Inclusion criteria included both hemoglobin A1c
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Kang KW, Choi BG, Rha SW Tags: Yonsei Med J Source Type: research

S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.
CONCLUSION: S100A4 was detected to be upregulated in NAFLD, while S100A4 KO alleviated liver fibrosis and inflammation, in addition to inhibiting hepatocyte apoptosis. PMID: 30328321 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Zhang YH, Ma Q, Ding P, Li J, Chen LL, Ao KJ, Tian YY Tags: Yonsei Med J Source Type: research

Seroepidemiology of Hepatitis Viruses and Hepatitis B Genotypes of Female Marriage Immigrants in Korea.
CONCLUSION: Testing for hepatitis viral marker (hepatitis A virus IgG and HBsAg/anti-HBs) is needed for female marriage immigrants. Especially, HBV genotype B is different from genotype C of Koreans. Therefore, interest and attention to vaccination programs for female marriage immigrants are necessary for both clinicians and public health institutes. PMID: 30328322 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Kwon JC, Chang HY, Kwon OY, Park JH, Oh IS, Kim HJ, Lee JH, Roh HJ, Lee HW Tags: Yonsei Med J Source Type: research

Effects of Antioxidant Tempol on Systematic Inflammation and Endothelial Apoptosis in Emphysematous Rats Exposed to Intermittent Hypoxia.
Abstract PURPOSE: Obstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease (CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the initial stage of CVD; however, underlying mechanisms linking OS and CVD are not well understood. The aim of this study was to explore whether OS can lead to more severe inflammation and endothelial apoptosis by promoting endothelial dysfunction, and to assess the intervention effects of antioxidant tempol. MATERIALS AND METHODS: Male Wistar rats (n=66) were exposed to normal oxyg...
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Zhao H, Zhao Y, Li X, Xu L, Jiang F, Hou W, Dong L, Cao J Tags: Yonsei Med J Source Type: research

Factors Associated with Lung Function Recovery at the First Year after Lung Transplantation.
Abstract PURPOSE: Post-operative pulmonary function is an important prognostic factor for lung transplantation. The purpose of this study was to identify factors affecting recovery of forced expiratory volume in 1 second (FEV1) at the first year after lung transplantation. MATERIALS AND METHODS: We retrospectively reviewed the medical records of lung transplantation patients between October 2012 and June 2016. Patients who survived for longer than one year and who underwent pulmonary function test at the first year of lung transplantation were enrolled. Patients were divided into two groups according to wheth...
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Yoon BR, Park JE, Kim CY, Park MS, Kim YS, Chung KS, Song JH, Paik HC, Lee JG, Kim SY Tags: Yonsei Med J Source Type: research

Inhibition of miR-128 Abates A β-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells.
CONCLUSION: MiR-128 inhibitor decreased Aβ-mediated cytotoxicity by upregulating PPAR-γ via inactivation of NF-κB in MCN and N2a cells, providing a new potential target in AD treatment. PMID: 30328325 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Geng L, Zhang T, Liu W, Chen Y Tags: Yonsei Med J Source Type: research

Preliminary Findings on the Effectiveness of Meaning-Centered Psychotherapy in Patients with Pancreatobiliary Cancer.
This study investigated the effectiveness of meaning-centered psychotherapy (MCP), which is known to be a helpful psychotherapeutic intervention in distressing conditions, for patients with pancreatobiliary cancer. MATERIALS AND METHODS: We recruited 37 patients with pancreatobiliary cancer from three university general hospitals and assessed their psychological characteristics. Patients who reported clinically significant emotional distress were recommended to undergo MCP. Patients who consented to MCP were provided four sessions of the therapy. Patient psychological characteristics were assessed again 2 months after...
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Ryu JS, Choi SW, Yun SS, Koo BH, Choi IS, Kim SJ, Park JS, Seok JH, Yoon DS Tags: Yonsei Med J Source Type: research

Biomechanical Properties of the Cornea Using a Dynamic Scheimpflug Analyzer in Healthy Eyes.
CONCLUSION: We demonstrated multiple corneal biomechanical parameters according to age, and reported that the corneal biomechanical parameters are influenced by IOP. PMID: 30328327 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Lee H, Kang DSY, Ha BJ, Choi JY, Kim EK, Seo KY, Kim TI Tags: Yonsei Med J Source Type: research

Indoor Radon and Lung Cancer: Estimation of Attributable Risk, Disease Burden, and Effects of Mitigation.
CONCLUSION: These findings suggest that indoor radon exposure contributes considerably to lung cancer, and that reducing indoor radon concentration would be helpful for decreasing the disease burden from lung cancer deaths. PMID: 30328328 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Kim SH, Koh SB, Lee CM, Kim C, Kang DR Tags: Yonsei Med J Source Type: research

Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment.
CONCLUSION: Our results show that the overexpression of TRPV4 can attenuate cell death in HEI-OC1 cells exposed to HG. PMID: 30328329 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Xing Y, Ming J, Liu T, Zhang N, Zha D, Lin Y Tags: Yonsei Med J Source Type: research

Hemodynamic, Autonomic, and Vascular Function Changes after Sleep Deprivation for 24, 28, and 32 Hours in Healthy Men.
This study aimed to analyze the impact of sleep deprivation (SD) on cardiac, hemodynamic, and endothelial parameters and to determine whether these are sustained with increased periods of SD. The study included 60 healthy men (mean: age 31.2±6.3 years; body mass index 24.6±2.6 kg/m²). Hemodynamic parameters, parameters of myocardial contractility, spectral analysis of heart rate (HR) and blood pressure (BP) variability, and the sensitivity of arterial baroreflex function were evaluated. Biochemical tests were performed to assess L-arginine (L-Arg) and asymmetric dimethylarginine (ADMA) levels in reflecti...
Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Słomko J, Zawadka-Kunikowska M, Kozakiewicz M, Klawe JJ, Tafil-Klawe M, Newton JL, Zalewski P Tags: Yonsei Med J Source Type: research

In Bae Yoon, an Inventor and Pioneer in Laparoscopic Surgery.
PMID: 30187696 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Bai SW Tags: Yonsei Med J Source Type: research

Stereotactic Body Radiotherapy: Does It Have a Role in Management of Hepatocellular Carcinoma?
Abstract Stereotactic body radiotherapy (SBRT) is a form of radiotherapy that delivers high doses of irradiation with high precision in a small number of fractions. However, it has not frequently been performed for the liver due to the risk of radiation-induced liver toxicity. Furthermore, liver SBRT is cumbersome because it requires accurate patient repositioning, target localization, control of breathing-related motion, and confers a toxicity risk to the small bowel. Recently, with the advancement of modern technologies including intensity-modulated RT and image-guided RT, SBRT has been shown to significantly im...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Choi SH, Seong J Tags: Yonsei Med J Source Type: research

Socioeconomic Inequalities in Stomach Cancer Screening in Korea, 2005-2015: After the Introduction of the National Cancer Screening Program.
CONCLUSION: Both education and income-related inequalities were found in stomach cancer screening, despite a continuous increase in screening rate over the study period. Income-related inequality was greater than education-related inequality, and this was more apparent in women than in men. PMID: 30187698 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Lee EY, Lee YY, Suh M, Choi E, Mai TTX, Cho H, Park B, Jun JK, Kim Y, Oh JK, Ki M, Choi KS Tags: Yonsei Med J Source Type: research

Outcomes of Non-High Grade Serous Carcinoma after Neoadjuvant Chemotherapy for Advanced-Stage Ovarian Cancer: Single-Institution Experience.
This study was a retrospective analysis of patients with advanced-stage ovarian cancer treated at Yonsei Cancer Hospital between 2006 and 2017. The demographics, chemotherapy response, and survival rates were compared between patients with non-HGSC and those with HGSC. RESULTS: Among 220 patients who underwent NAC, 25 (11.4%) patients had non-HGSC histologic subtypes, and all received a taxane-platinum combination regimen for NAC. Patients with non-HGSC had lower baseline cancer antigen-125 levels (p
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Chung YS, Lee JY, Kim HS, Nam EJ, Kim SW, Kim YT Tags: Yonsei Med J Source Type: research

Clinical Implications of Moderate Coronary Stenosis on Coronary Computed Tomography Angiography in Patients with Stable Angina.
Abstract PURPOSE: The present study investigated the diagnostic accuracy and clinical implications of moderate stenosis (50-69%, Coronary Artery Disease Reporting and Data System, grade 3) on coronary computed tomography angiography (CCTA), compared with invasive coronary angiography (ICA). MATERIALS AND METHODS: Two hundred and seventy-six patients who underwent ICA due to moderate stenosis alone on CCTA were selected from our prospective registry cohort. RESULTS: Diagnostic concordance between CCTA and ICA was found in only 50 (18%) patients. Among the 396 vessels and 508 segments with moderate stenosi...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Kim C, Hong SJ, Ahn CM, Kim JS, Kim BK, Ko YG, Choi BW, Choi D, Jang Y, Hong MK Tags: Yonsei Med J Source Type: research

Regulation of Colonic Mucosal MicroRNA Expression via Multiple Targets in Visceral Hypersensitivity Rats by Tongxieyaofang.
This study aimed to screen for differentially expressed microRNAs (miRNAs) in the colons of rats with visceral hypersensitivity to build the expression profiles of miRNAs therein and to determine the mechanism of Tongxieyaofang use in the treatment of irritable bowel syndrome (IBS). MATERIALS AND METHODS: Forty Sprague-Dawley rats were divided randomly into four groups: control group, model control group (induced by rectum stimulus and evaluated by abdominal withdraw reaction), treatment control group (normal saline), and Tongxieyaofang group (treated with Tongxieyaofang). We screened for differential expression of co...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Chao G, Wang Y, Ye F, Zhang S Tags: Yonsei Med J Source Type: research

Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis.
Abstract PURPOSE: Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new PPI, ilaprazole, on patients with heartburn but without reflux esophagitis. MATERIALS AND METHODS: This prospective study was performed on 20 patients with heartburn but without reflux esophagitis. All patients underwent upper endoscopy and 24-hr combined multichannel intraluminal impedance and pH esophageal monitoring (MII-pH). They were then treated with ilaprazole (20 mg) once daily for 4 weeks. The...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Song IJ, Kim HK, Lee NK, Lee SK Tags: Yonsei Med J Source Type: research

Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats.
CONCLUSION: Exogenous H₂S can mitigate IR injury-led renal damage. The proposed beneficial effect of H₂S is, in part, because of the anti-oxidative stress associated with modulation of the MAPK signaling pathways. PMID: 30187703 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Choi EK, Park SH, Lim JA, Hong SW, Kwak KH, Park SS, Lim DG, Jung H Tags: Yonsei Med J Source Type: research

Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy.
This study aimed to evaluate the proper cut-off levels of sIgE in the diagnosis of immediate hypersensitivity to cefaclor. MATERIALS AND METHODS: A total of 269 patients with drug allergy history, who underwent assays of sIgE to cefaclor at Ajou University hospital and Dong-A University Hospital, were reviewed retrospectively. Among them, 193 patients exhibited cefaclor-induced immediate hypersensitivity with certain or probable causality of an adverse drug reaction according to the WHO-UMC (the World Health Organization-the Uppsala Monitoring Centre) algorithm, and 76 controls showed delayed hypersensitivity reaction...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Nam YH, Lee SH, Rhyou HI, Lee YS, Park SH, Lee YH, Shin YS, Park HS, Ye YM Tags: Yonsei Med J Source Type: research

Efficacy and Safety of Robotic Procedures Performed Using the da Vinci Robotic Surgical System at a Single Institute in Korea: Experience with 10000 Cases.
CONCLUSION: Robotic surgeries have increased steadily at our institution. The da Vinci Robotic Surgical System is effective and safe for use during surgery. PMID: 30187705 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Koh DH, Jang WS, Park JW, Ham WS, Han WK, Rha KH, Choi YD Tags: Yonsei Med J Source Type: research

Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning.
CONCLUSION: Although the majority of NORP patients were admitted to the ED with unintentional poisoning and the relative risk of NORP was lower than that for ORP, we concluded that NORP is as critical as ORP. Considerable medical observation and intensive therapeutic approaches are also needed for NORP patients. PMID: 30187706 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Jung WJ, Yu MH, Lee Y, Kim H, Cha YS, Park KH Tags: Yonsei Med J Source Type: research

Pediatric Trampoline-Related Injuries in a Nationwide Registry in South Korea, 2011 to 2016.
Abstract PURPOSE: Trampoline-related injuries are steadily increasing. To our knowledge, there have been very few studies on trampoline injuries in Asia. The purpose of this study is to report the characteristics of pediatric trampoline injuries in Korea. MATERIALS AND METHODS: We conducted a nationwide retrospective cohort study. Data were collected from prospective nationwide databases (Emergency Department-based Injury In-depth Surveillance databases of the Korea Centers for Disease Control and Prevention) for patients who visited emergency departments (EDs) after injuries during 2011-2016. RESULTS: O...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Choi ES, Jang JH, Woo JH, Choi JU, Cho JS, Yang HJ Tags: Yonsei Med J Source Type: research

Development of a Novel Nonradioisotopic Assay and Cdc25B Overexpression Cell Lines for Use in Screening for Cdc25B Inhibitors.
CONCLUSION: The nonradioisotopic Cdk1 kinase assay and Cdc25B overexpression cell lines developed in this study can be conveniently used as tools for screening inhibitors of Cdc25B phosphatase as anticancer drugs. PMID: 30187708 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Ha GS, Lee CM, Kim CW Tags: Yonsei Med J Source Type: research

Bronchiectasis and Recurrent Respiratory Infections with a De Novo STAT1 Gain-of-Function Variant: First Case in Korea.
Abstract Bronchiectasis is a chronic disease characterized by airway infection and inflammation, leading to permanent dilation of the bronchi. Evaluation of underlying etiology is important in managing young bronchiectasis patients with recurrent infections caused by unusual pathogens. The signal transducer and activator of transcription 1 (STAT1) protein plays a key role in STAT signaling and immune system regulation. Heterozygotes for gain-of-function (GOF) alleles of the STAT1 gene usually display autosomal dominant chronic mucocutaneous candidiasis (CMC) and a wide range of clinical features, such as bronchiec...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Huh HJ, Jhun BW, Choi SR, Kim YJ, Yun SA, Nham E, Kong T, Ki CS, Koh WJ Tags: Yonsei Med J Source Type: research

Genotypic and Phenotypic Heterogeneity of LGMD1D due to DNAJB6 Mutations.
PMID: 30187710 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Finsterer J Tags: Yonsei Med J Source Type: research

The Author Reply: Genotypic and Phenotypic Heterogeneity of LGMD1D due to DNAJB6 Mutations.
PMID: 30187711 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Kim K, Choi YC Tags: Yonsei Med J Source Type: research

Generation, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells.
Abstract Dendritic cells (DCs) play a key role not only in the initiation of primary immune responses, but also in the development and maintenance of immune tolerance. Numerous protocols have been developed to generate tolerogenic DCs (tolDCs) ex vivo, and the therapeutic efficacy of ex vivo-generated tolDCs has been demonstrated in autoimmune disease animal models. Based on successes in small animal models, several clinical trials have been completed or are on-going in patients with autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, and Crohn's disease. Here we describe the met...
Source: Yonsei Medical Journal - August 11, 2018 Category: Universities & Medical Training Authors: Kim SH, Jung HH, Lee CK Tags: Yonsei Med J Source Type: research

XIST Induced by JPX Suppresses Hepatocellular Carcinoma by Sponging miR-155-5p.
CONCLUSION: JPX and XIST play a suppressive role in HCC. JPX increases expression levels of XIST in HCC cells, which suppresses HCC development by sponging the cancer promoting miR-155-5p. PMID: 30091314 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 11, 2018 Category: Universities & Medical Training Authors: Lin XQ, Huang ZM, Chen X, Wu F, Wu W Tags: Yonsei Med J Source Type: research