Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea
Yonsei Med J. 2021 Apr;62(4):279-287. doi: 10.3349/ymj.2021.62.4.279.ABSTRACTSmall vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity an...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Sung Soo Ahn Yong Beom Park Sang Won Lee Source Type: research

Clinical Impact of Natural Killer Group 2D Receptor Expression and That of Its Ligand in Ovarian Carcinomas: A Retrospective Study
CONCLUSION: High expression of ULBP1 predicts a better prognosis for HGSC, suggesting that ULBP1 expression could be a novel prognostic indicator in this subset of carcinomas.PMID:33779082 | PMC:PMC8007423 | DOI:10.3349/ymj.2021.62.4.288 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Gee Hoon Lee Hee Jung An Tae Hoen Kim Gwangil Kim Kyung Soon Park Hyun Park Tae Ho Lee Ah Young Kwon Source Type: research

Changes in Cardiovascular Health Status and Risk of Sudden Cardiac Death in Older Adults
CONCLUSION: Maintaining a high CVH status was associated with future risks of SCD and all-cause death among an older adult population.PMID:33779083 | PMC:PMC8007437 | DOI:10.3349/ymj.2021.62.4.298 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Min Kim Pil Sung Yang Hee Tae Yu Tae Hoon Kim Eunsun Jang Jae Sun Uhm Hui Nam Pak Moon Hyoung Lee Boyoung Joung Source Type: research

Antimicrobial Susceptibility Trends of < em > Streptococcus pneumoniae < /em > by Age Groups Over Recent 10 Years in a Single Hospital in South Korea
CONCLUSION: Erythromycin and ceftriaxone resistance rates and the MDR rate of S. pneumoniae significantly increased during the recent 10 years; the trends in individual antimicrobial resistance rates significantly differed between the age groups. This study indicates the need for caution when using ceftriaxone as an empirical antimicrobial against pneumococcal infections.PMID:33779084 | PMC:PMC8007430 | DOI:10.3349/ymj.2021.62.4.306 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Hyunjoo Oh Sang Taek Heo Misun Kim Young Ree Kim Jeong Rae Yoo Source Type: research

Different Seasonal Variations of Potassium in Hemodialysis Patients with High Longitudinal Potassium Levels: A Multicenter Cohort Study Using DialysisNet
Yonsei Med J. 2021 Apr;62(4):315-324. doi: 10.3349/ymj.2021.62.4.315.ABSTRACTPURPOSE: To determine seasonal variations in serum potassium levels among hemodialysis patients.MATERIALS AND METHODS: This was a multicenter cohort study of patients whounderwent hemodialysis and were registered in DialysisNet at our four associated general hospitals between January and December 2016. Month-to-month potassium variability was quantified as SD/√{n/(n-1)}, and a non-hierarchical method was used to cluster groups according to potassium trajectories. Seasonal variations in potassium levels were analyzed using a cosinor analysis....
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Yunmi Kim Seong Han Yun Hoseok Koo Subin Hwang Hyo Jin Kim Sunhwa Lee Hyunjeong Baek Hye Hyeon Kim Kye Hwa Lee Ju Han Kim Ji In Park Kyung Don Yoo Source Type: research

Inhibition of Long Noncoding RNA SNHG15 Ameliorates Hypoxia/Ischemia-Induced Neuronal Damage by Regulating miR-302a-3p/STAT1/NF- κB Axis
CONCLUSION: SNHG15 was up-regulated in the hypoxia/ischemia mouse or cell model. The inhibition of SNHG15 ameliorates ischemia/hypoxia-induced neuronal damage and microglial inflammation by regulating the miR-302a-3p/STAT1/NF-κB pathway.PMID:33779086 | PMC:PMC8007436 | DOI:10.3349/ymj.2021.62.4.325 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Chunting Hu Chen Li Qiaoya Ma Ruili Wang Ya He Hui Wang Guogang Luo Source Type: research

Clinical Course of Amyotrophic Lateral Sclerosis according to Initial Symptoms: An Analysis of 500 Cases
Yonsei Med J. 2021 Apr;62(4):338-343. doi: 10.3349/ymj.2021.62.4.338.ABSTRACTPURPOSE: One obstacle in early diagnosis of amyotrophic lateral sclerosis (ALS) is its vague initial presentation, which is generally classified into limb- and bulbar-dominant types and may be mistaken for other musculoskeletal conditions. We analyzed clinical data from patients in relation to their initial presentation and prognosis from symptom onset to diagnosis.MATERIALS AND METHODS: We retrospectively analyzed the medical records of patients with ALS who were admitted for pulmonary rehabilitation between January 2007 and December 2019. We col...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Jang Woo Lee Seong Woong Kang Won Ah Choi Source Type: research

Ten-Year Trends of Metabolic Syndrome Prevalence and Nutrient Intake among Korean Children and Adolescents: A Population-Based Study
CONCLUSION: Over the last 10 years, the prevalence of MetS has grown significantly with increasing calorie and fat intake in Korean children and adolescents. Central obesity and high-density lipoprotein cholesterol and fasting glucose levels have worsened. Therefore, active support and close monitoring are required to control MetS and prevent further increase in the prevalence of cardiovascular diseases.PMID:33779088 | PMC:PMC8007432 | DOI:10.3349/ymj.2021.62.4.344 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Seong Ik Park Junghwan Suh Hye Sun Lee Kyungchul Song Youngha Choi Jun Suk Oh Han Saem Choi Ahreum Kwon Ho Seong Kim Jae Hyun Kim Hyun Wook Chae Source Type: research

Comparison of Base Deficit and Vital Signs as Criteria for Hemorrhagic Shock Classification in Children with Trauma
Yonsei Med J. 2021 Apr;62(4):352-358. doi: 10.3349/ymj.2021.62.4.352.ABSTRACTPURPOSE: Base deficit (BD) is superior to vital signs in predicting trauma outcomes in adults. The authors aimed to compare BD and vital signs as criteria for the four-tiered hemorrhagic shock classification in children with trauma.MATERIALS AND METHODS: We retrospectively reviewed the data of 1046 injured children who visited a Korean academic hospital from 2010 through 2018. These children were classified separately based on BD (class I, BD ≤2.0 mmol/L; II, 2.1-6.0 mmol/L; III, 6.1-10 mmol/L; and IV, ≥10.1 mmol/L) and vital signs (
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Yura Ko Jung Heon Kim Kyungjin Hwang Jisook Lee Yo Huh Source Type: research

Association between < em > BDNF < /em > Polymorphism and Depressive Symptoms in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
CONCLUSION: Depressive symptoms are associated with the presence of the Met-carriers and lower HbA1c in patients newly diagnosed with T2DM.PMID:33779090 | PMC:PMC8007434 | DOI:10.3349/ymj.2021.62.4.359 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Jin Sun Ryu Young Mi Lee Yu Sik Kim Shinae Kang Jong Suk Park Chul Woo Ahn Ji Sun Nam Jeong Ho Seok Source Type: research

Comparison of the Prognostic Outcome between High-Grade Ovarian Sertoli-Leydig Cell Tumors (SLCTs) and Low-Grade SLCTs
Yonsei Med J. 2021 Apr;62(4):366-369. doi: 10.3349/ymj.2021.62.4.366.ABSTRACTThe purpose of the current study was to compare prognostic outcomes between patients with high-grade ovarian Sertoli-Leydig cell tumors (SLCTs) and those with other low-grade SLCTs. We retrospectively reviewed medical records for 24 patients pathologically diagnosed with SLCTs between 2006 to 2019 at two institutions. The patients were grouped according to pathological grade: SLCT was classified as grade 1, well differentiated; grade 2, intermediated differentiated; or grade 3, poorly differentiated (Meyer's classification). Statistical analysis w...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Kyung Jin Eoh Junsik Park Hye Min Kim Maria Lee Young Tae Kim Source Type: research

Ketogenic Diet in Infants with Early-Onset Epileptic Encephalopathy and < em > SCN2A < /em > Mutation
Yonsei Med J. 2021 Apr;62(4):370-373. doi: 10.3349/ymj.2021.62.4.370.ABSTRACTResearch has shown mutations in the voltage-gated sodium channel gene SCN2A to be associated with developmental delays and infantile seizures in patients with early-onset epileptic encephalopathies (EOEEs). Here, we report the case of an infant with a de novo SCN2A mutation with EOEE who had medically refractory seizures that improved with a ketogenic diet (KD) implemented at an age less than 2 months. On the day of his birth, the infant presented with a pattern of convulsions with dozens of episodes per day. An initial video electroencephalogram ...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Xiaoyu Tian Yange Zhang Jinhong Zhang Yan Lu Xinyi Men Xiuxia Wang Source Type: research

Author Reply: Factors to Consider When Interpreting the Diagnostic Performance of Fine-Needle Aspiration and Core-Needle Biopsy in Specific Patient Population
Yonsei Med J. 2021 Apr;62(4):376-377. doi: 10.3349/ymj.2021.62.4.376.NO ABSTRACTPMID:33779093 | PMC:PMC8007435 | DOI:10.3349/ymj.2021.62.4.376 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Ilah Shin Jin Young Kwak Source Type: research

Factors to Consider When Interpreting the Diagnostic Performance of Fine-Needle Aspiration and Core-Needle Biopsy in a Specific Study Population
Yonsei Med J. 2021 Apr;62(4):374-375. doi: 10.3349/ymj.2021.62.4.374.NO ABSTRACTPMID:33779094 | PMC:PMC8007426 | DOI:10.3349/ymj.2021.62.4.374 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Dong Gyu Na Source Type: research

Erratum to "LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer" by Byun HJ, et al. (Yonsei Med J 2020; 61(11): 923-934.)
Yonsei Med J. 2021 Apr;62(4):378. doi: 10.3349/ymj.2021.62.4.378.ABSTRACTThis corrects the article on p. 923 in vol. 61, PMID: 33107235.PMID:33779095 | PMC:PMC8007425 | DOI:10.3349/ymj.2021.62.4.378 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Source Type: research

Erratum to "Genetic Analysis of Korean Adult Patients with Nontuberculous Mycobacteria Suspected of Primary Ciliary Dyskinesia Using Whole Exome Sequencing" by Cho EH, et al. (Yonsei Med J 2021; 62(3): 224-230.)
Yonsei Med J. 2021 Apr;62(4):379. doi: 10.3349/ymj.2021.62.4.379.ABSTRACTThis corrects the article on p. 224 in vol. 62, PMID: 33635012.PMID:33779096 | PMC:PMC8007428 | DOI:10.3349/ymj.2021.62.4.379 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Source Type: research

Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea
Yonsei Med J. 2021 Apr;62(4):279-287. doi: 10.3349/ymj.2021.62.4.279.ABSTRACTSmall vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity an...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Sung Soo Ahn Yong Beom Park Sang Won Lee Source Type: research

Clinical Impact of Natural Killer Group 2D Receptor Expression and That of Its Ligand in Ovarian Carcinomas: A Retrospective Study
CONCLUSION: High expression of ULBP1 predicts a better prognosis for HGSC, suggesting that ULBP1 expression could be a novel prognostic indicator in this subset of carcinomas.PMID:33779082 | PMC:PMC8007423 | DOI:10.3349/ymj.2021.62.4.288 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Gee Hoon Lee Hee Jung An Tae Hoen Kim Gwangil Kim Kyung Soon Park Hyun Park Tae Ho Lee Ah Young Kwon Source Type: research

Changes in Cardiovascular Health Status and Risk of Sudden Cardiac Death in Older Adults
CONCLUSION: Maintaining a high CVH status was associated with future risks of SCD and all-cause death among an older adult population.PMID:33779083 | PMC:PMC8007437 | DOI:10.3349/ymj.2021.62.4.298 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Min Kim Pil Sung Yang Hee Tae Yu Tae Hoon Kim Eunsun Jang Jae Sun Uhm Hui Nam Pak Moon Hyoung Lee Boyoung Joung Source Type: research

Antimicrobial Susceptibility Trends of < em > Streptococcus pneumoniae < /em > by Age Groups Over Recent 10 Years in a Single Hospital in South Korea
CONCLUSION: Erythromycin and ceftriaxone resistance rates and the MDR rate of S. pneumoniae significantly increased during the recent 10 years; the trends in individual antimicrobial resistance rates significantly differed between the age groups. This study indicates the need for caution when using ceftriaxone as an empirical antimicrobial against pneumococcal infections.PMID:33779084 | PMC:PMC8007430 | DOI:10.3349/ymj.2021.62.4.306 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Hyunjoo Oh Sang Taek Heo Misun Kim Young Ree Kim Jeong Rae Yoo Source Type: research

Different Seasonal Variations of Potassium in Hemodialysis Patients with High Longitudinal Potassium Levels: A Multicenter Cohort Study Using DialysisNet
Yonsei Med J. 2021 Apr;62(4):315-324. doi: 10.3349/ymj.2021.62.4.315.ABSTRACTPURPOSE: To determine seasonal variations in serum potassium levels among hemodialysis patients.MATERIALS AND METHODS: This was a multicenter cohort study of patients whounderwent hemodialysis and were registered in DialysisNet at our four associated general hospitals between January and December 2016. Month-to-month potassium variability was quantified as SD/√{n/(n-1)}, and a non-hierarchical method was used to cluster groups according to potassium trajectories. Seasonal variations in potassium levels were analyzed using a cosinor analysis....
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Yunmi Kim Seong Han Yun Hoseok Koo Subin Hwang Hyo Jin Kim Sunhwa Lee Hyunjeong Baek Hye Hyeon Kim Kye Hwa Lee Ju Han Kim Ji In Park Kyung Don Yoo Source Type: research

Inhibition of Long Noncoding RNA SNHG15 Ameliorates Hypoxia/Ischemia-Induced Neuronal Damage by Regulating miR-302a-3p/STAT1/NF- κB Axis
CONCLUSION: SNHG15 was up-regulated in the hypoxia/ischemia mouse or cell model. The inhibition of SNHG15 ameliorates ischemia/hypoxia-induced neuronal damage and microglial inflammation by regulating the miR-302a-3p/STAT1/NF-κB pathway.PMID:33779086 | PMC:PMC8007436 | DOI:10.3349/ymj.2021.62.4.325 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Chunting Hu Chen Li Qiaoya Ma Ruili Wang Ya He Hui Wang Guogang Luo Source Type: research

Clinical Course of Amyotrophic Lateral Sclerosis according to Initial Symptoms: An Analysis of 500 Cases
Yonsei Med J. 2021 Apr;62(4):338-343. doi: 10.3349/ymj.2021.62.4.338.ABSTRACTPURPOSE: One obstacle in early diagnosis of amyotrophic lateral sclerosis (ALS) is its vague initial presentation, which is generally classified into limb- and bulbar-dominant types and may be mistaken for other musculoskeletal conditions. We analyzed clinical data from patients in relation to their initial presentation and prognosis from symptom onset to diagnosis.MATERIALS AND METHODS: We retrospectively analyzed the medical records of patients with ALS who were admitted for pulmonary rehabilitation between January 2007 and December 2019. We col...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Jang Woo Lee Seong Woong Kang Won Ah Choi Source Type: research

Ten-Year Trends of Metabolic Syndrome Prevalence and Nutrient Intake among Korean Children and Adolescents: A Population-Based Study
CONCLUSION: Over the last 10 years, the prevalence of MetS has grown significantly with increasing calorie and fat intake in Korean children and adolescents. Central obesity and high-density lipoprotein cholesterol and fasting glucose levels have worsened. Therefore, active support and close monitoring are required to control MetS and prevent further increase in the prevalence of cardiovascular diseases.PMID:33779088 | PMC:PMC8007432 | DOI:10.3349/ymj.2021.62.4.344 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Seong Ik Park Junghwan Suh Hye Sun Lee Kyungchul Song Youngha Choi Jun Suk Oh Han Saem Choi Ahreum Kwon Ho Seong Kim Jae Hyun Kim Hyun Wook Chae Source Type: research

Comparison of Base Deficit and Vital Signs as Criteria for Hemorrhagic Shock Classification in Children with Trauma
Yonsei Med J. 2021 Apr;62(4):352-358. doi: 10.3349/ymj.2021.62.4.352.ABSTRACTPURPOSE: Base deficit (BD) is superior to vital signs in predicting trauma outcomes in adults. The authors aimed to compare BD and vital signs as criteria for the four-tiered hemorrhagic shock classification in children with trauma.MATERIALS AND METHODS: We retrospectively reviewed the data of 1046 injured children who visited a Korean academic hospital from 2010 through 2018. These children were classified separately based on BD (class I, BD ≤2.0 mmol/L; II, 2.1-6.0 mmol/L; III, 6.1-10 mmol/L; and IV, ≥10.1 mmol/L) and vital signs (
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Yura Ko Jung Heon Kim Kyungjin Hwang Jisook Lee Yo Huh Source Type: research

Association between < em > BDNF < /em > Polymorphism and Depressive Symptoms in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
CONCLUSION: Depressive symptoms are associated with the presence of the Met-carriers and lower HbA1c in patients newly diagnosed with T2DM.PMID:33779090 | PMC:PMC8007434 | DOI:10.3349/ymj.2021.62.4.359 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Jin Sun Ryu Young Mi Lee Yu Sik Kim Shinae Kang Jong Suk Park Chul Woo Ahn Ji Sun Nam Jeong Ho Seok Source Type: research

Comparison of the Prognostic Outcome between High-Grade Ovarian Sertoli-Leydig Cell Tumors (SLCTs) and Low-Grade SLCTs
Yonsei Med J. 2021 Apr;62(4):366-369. doi: 10.3349/ymj.2021.62.4.366.ABSTRACTThe purpose of the current study was to compare prognostic outcomes between patients with high-grade ovarian Sertoli-Leydig cell tumors (SLCTs) and those with other low-grade SLCTs. We retrospectively reviewed medical records for 24 patients pathologically diagnosed with SLCTs between 2006 to 2019 at two institutions. The patients were grouped according to pathological grade: SLCT was classified as grade 1, well differentiated; grade 2, intermediated differentiated; or grade 3, poorly differentiated (Meyer's classification). Statistical analysis w...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Kyung Jin Eoh Junsik Park Hye Min Kim Maria Lee Young Tae Kim Source Type: research

Ketogenic Diet in Infants with Early-Onset Epileptic Encephalopathy and < em > SCN2A < /em > Mutation
Yonsei Med J. 2021 Apr;62(4):370-373. doi: 10.3349/ymj.2021.62.4.370.ABSTRACTResearch has shown mutations in the voltage-gated sodium channel gene SCN2A to be associated with developmental delays and infantile seizures in patients with early-onset epileptic encephalopathies (EOEEs). Here, we report the case of an infant with a de novo SCN2A mutation with EOEE who had medically refractory seizures that improved with a ketogenic diet (KD) implemented at an age less than 2 months. On the day of his birth, the infant presented with a pattern of convulsions with dozens of episodes per day. An initial video electroencephalogram ...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Xiaoyu Tian Yange Zhang Jinhong Zhang Yan Lu Xinyi Men Xiuxia Wang Source Type: research

Author Reply: Factors to Consider When Interpreting the Diagnostic Performance of Fine-Needle Aspiration and Core-Needle Biopsy in Specific Patient Population
Yonsei Med J. 2021 Apr;62(4):376-377. doi: 10.3349/ymj.2021.62.4.376.NO ABSTRACTPMID:33779093 | PMC:PMC8007435 | DOI:10.3349/ymj.2021.62.4.376 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Ilah Shin Jin Young Kwak Source Type: research

Factors to Consider When Interpreting the Diagnostic Performance of Fine-Needle Aspiration and Core-Needle Biopsy in a Specific Study Population
Yonsei Med J. 2021 Apr;62(4):374-375. doi: 10.3349/ymj.2021.62.4.374.NO ABSTRACTPMID:33779094 | PMC:PMC8007426 | DOI:10.3349/ymj.2021.62.4.374 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Dong Gyu Na Source Type: research

Erratum to "LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer" by Byun HJ, et al. (Yonsei Med J 2020; 61(11): 923-934.)
Yonsei Med J. 2021 Apr;62(4):378. doi: 10.3349/ymj.2021.62.4.378.ABSTRACTThis corrects the article on p. 923 in vol. 61, PMID: 33107235.PMID:33779095 | PMC:PMC8007425 | DOI:10.3349/ymj.2021.62.4.378 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Source Type: research

Erratum to "Genetic Analysis of Korean Adult Patients with Nontuberculous Mycobacteria Suspected of Primary Ciliary Dyskinesia Using Whole Exome Sequencing" by Cho EH, et al. (Yonsei Med J 2021; 62(3): 224-230.)
Yonsei Med J. 2021 Apr;62(4):379. doi: 10.3349/ymj.2021.62.4.379.ABSTRACTThis corrects the article on p. 224 in vol. 62, PMID: 33635012.PMID:33779096 | PMC:PMC8007428 | DOI:10.3349/ymj.2021.62.4.379 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Source Type: research

Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea
Yonsei Med J. 2021 Apr;62(4):279-287. doi: 10.3349/ymj.2021.62.4.279.ABSTRACTSmall vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity an...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Sung Soo Ahn Yong Beom Park Sang Won Lee Source Type: research

Clinical Impact of Natural Killer Group 2D Receptor Expression and That of Its Ligand in Ovarian Carcinomas: A Retrospective Study
CONCLUSION: High expression of ULBP1 predicts a better prognosis for HGSC, suggesting that ULBP1 expression could be a novel prognostic indicator in this subset of carcinomas.PMID:33779082 | PMC:PMC8007423 | DOI:10.3349/ymj.2021.62.4.288 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Gee Hoon Lee Hee Jung An Tae Hoen Kim Gwangil Kim Kyung Soon Park Hyun Park Tae Ho Lee Ah Young Kwon Source Type: research

Changes in Cardiovascular Health Status and Risk of Sudden Cardiac Death in Older Adults
CONCLUSION: Maintaining a high CVH status was associated with future risks of SCD and all-cause death among an older adult population.PMID:33779083 | PMC:PMC8007437 | DOI:10.3349/ymj.2021.62.4.298 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Min Kim Pil Sung Yang Hee Tae Yu Tae Hoon Kim Eunsun Jang Jae Sun Uhm Hui Nam Pak Moon Hyoung Lee Boyoung Joung Source Type: research

Antimicrobial Susceptibility Trends of < em > Streptococcus pneumoniae < /em > by Age Groups Over Recent 10 Years in a Single Hospital in South Korea
CONCLUSION: Erythromycin and ceftriaxone resistance rates and the MDR rate of S. pneumoniae significantly increased during the recent 10 years; the trends in individual antimicrobial resistance rates significantly differed between the age groups. This study indicates the need for caution when using ceftriaxone as an empirical antimicrobial against pneumococcal infections.PMID:33779084 | PMC:PMC8007430 | DOI:10.3349/ymj.2021.62.4.306 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Hyunjoo Oh Sang Taek Heo Misun Kim Young Ree Kim Jeong Rae Yoo Source Type: research

Different Seasonal Variations of Potassium in Hemodialysis Patients with High Longitudinal Potassium Levels: A Multicenter Cohort Study Using DialysisNet
Yonsei Med J. 2021 Apr;62(4):315-324. doi: 10.3349/ymj.2021.62.4.315.ABSTRACTPURPOSE: To determine seasonal variations in serum potassium levels among hemodialysis patients.MATERIALS AND METHODS: This was a multicenter cohort study of patients whounderwent hemodialysis and were registered in DialysisNet at our four associated general hospitals between January and December 2016. Month-to-month potassium variability was quantified as SD/√{n/(n-1)}, and a non-hierarchical method was used to cluster groups according to potassium trajectories. Seasonal variations in potassium levels were analyzed using a cosinor analysis....
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Yunmi Kim Seong Han Yun Hoseok Koo Subin Hwang Hyo Jin Kim Sunhwa Lee Hyunjeong Baek Hye Hyeon Kim Kye Hwa Lee Ju Han Kim Ji In Park Kyung Don Yoo Source Type: research

Inhibition of Long Noncoding RNA SNHG15 Ameliorates Hypoxia/Ischemia-Induced Neuronal Damage by Regulating miR-302a-3p/STAT1/NF- κB Axis
CONCLUSION: SNHG15 was up-regulated in the hypoxia/ischemia mouse or cell model. The inhibition of SNHG15 ameliorates ischemia/hypoxia-induced neuronal damage and microglial inflammation by regulating the miR-302a-3p/STAT1/NF-κB pathway.PMID:33779086 | PMC:PMC8007436 | DOI:10.3349/ymj.2021.62.4.325 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Chunting Hu Chen Li Qiaoya Ma Ruili Wang Ya He Hui Wang Guogang Luo Source Type: research

Clinical Course of Amyotrophic Lateral Sclerosis according to Initial Symptoms: An Analysis of 500 Cases
Yonsei Med J. 2021 Apr;62(4):338-343. doi: 10.3349/ymj.2021.62.4.338.ABSTRACTPURPOSE: One obstacle in early diagnosis of amyotrophic lateral sclerosis (ALS) is its vague initial presentation, which is generally classified into limb- and bulbar-dominant types and may be mistaken for other musculoskeletal conditions. We analyzed clinical data from patients in relation to their initial presentation and prognosis from symptom onset to diagnosis.MATERIALS AND METHODS: We retrospectively analyzed the medical records of patients with ALS who were admitted for pulmonary rehabilitation between January 2007 and December 2019. We col...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Jang Woo Lee Seong Woong Kang Won Ah Choi Source Type: research

Ten-Year Trends of Metabolic Syndrome Prevalence and Nutrient Intake among Korean Children and Adolescents: A Population-Based Study
CONCLUSION: Over the last 10 years, the prevalence of MetS has grown significantly with increasing calorie and fat intake in Korean children and adolescents. Central obesity and high-density lipoprotein cholesterol and fasting glucose levels have worsened. Therefore, active support and close monitoring are required to control MetS and prevent further increase in the prevalence of cardiovascular diseases.PMID:33779088 | PMC:PMC8007432 | DOI:10.3349/ymj.2021.62.4.344 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Seong Ik Park Junghwan Suh Hye Sun Lee Kyungchul Song Youngha Choi Jun Suk Oh Han Saem Choi Ahreum Kwon Ho Seong Kim Jae Hyun Kim Hyun Wook Chae Source Type: research

Comparison of Base Deficit and Vital Signs as Criteria for Hemorrhagic Shock Classification in Children with Trauma
Yonsei Med J. 2021 Apr;62(4):352-358. doi: 10.3349/ymj.2021.62.4.352.ABSTRACTPURPOSE: Base deficit (BD) is superior to vital signs in predicting trauma outcomes in adults. The authors aimed to compare BD and vital signs as criteria for the four-tiered hemorrhagic shock classification in children with trauma.MATERIALS AND METHODS: We retrospectively reviewed the data of 1046 injured children who visited a Korean academic hospital from 2010 through 2018. These children were classified separately based on BD (class I, BD ≤2.0 mmol/L; II, 2.1-6.0 mmol/L; III, 6.1-10 mmol/L; and IV, ≥10.1 mmol/L) and vital signs (
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Yura Ko Jung Heon Kim Kyungjin Hwang Jisook Lee Yo Huh Source Type: research

Association between < em > BDNF < /em > Polymorphism and Depressive Symptoms in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
CONCLUSION: Depressive symptoms are associated with the presence of the Met-carriers and lower HbA1c in patients newly diagnosed with T2DM.PMID:33779090 | PMC:PMC8007434 | DOI:10.3349/ymj.2021.62.4.359 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Jin Sun Ryu Young Mi Lee Yu Sik Kim Shinae Kang Jong Suk Park Chul Woo Ahn Ji Sun Nam Jeong Ho Seok Source Type: research

Comparison of the Prognostic Outcome between High-Grade Ovarian Sertoli-Leydig Cell Tumors (SLCTs) and Low-Grade SLCTs
Yonsei Med J. 2021 Apr;62(4):366-369. doi: 10.3349/ymj.2021.62.4.366.ABSTRACTThe purpose of the current study was to compare prognostic outcomes between patients with high-grade ovarian Sertoli-Leydig cell tumors (SLCTs) and those with other low-grade SLCTs. We retrospectively reviewed medical records for 24 patients pathologically diagnosed with SLCTs between 2006 to 2019 at two institutions. The patients were grouped according to pathological grade: SLCT was classified as grade 1, well differentiated; grade 2, intermediated differentiated; or grade 3, poorly differentiated (Meyer's classification). Statistical analysis w...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Kyung Jin Eoh Junsik Park Hye Min Kim Maria Lee Young Tae Kim Source Type: research

Ketogenic Diet in Infants with Early-Onset Epileptic Encephalopathy and < em > SCN2A < /em > Mutation
Yonsei Med J. 2021 Apr;62(4):370-373. doi: 10.3349/ymj.2021.62.4.370.ABSTRACTResearch has shown mutations in the voltage-gated sodium channel gene SCN2A to be associated with developmental delays and infantile seizures in patients with early-onset epileptic encephalopathies (EOEEs). Here, we report the case of an infant with a de novo SCN2A mutation with EOEE who had medically refractory seizures that improved with a ketogenic diet (KD) implemented at an age less than 2 months. On the day of his birth, the infant presented with a pattern of convulsions with dozens of episodes per day. An initial video electroencephalogram ...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Xiaoyu Tian Yange Zhang Jinhong Zhang Yan Lu Xinyi Men Xiuxia Wang Source Type: research

Author Reply: Factors to Consider When Interpreting the Diagnostic Performance of Fine-Needle Aspiration and Core-Needle Biopsy in Specific Patient Population
Yonsei Med J. 2021 Apr;62(4):376-377. doi: 10.3349/ymj.2021.62.4.376.NO ABSTRACTPMID:33779093 | PMC:PMC8007435 | DOI:10.3349/ymj.2021.62.4.376 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Ilah Shin Jin Young Kwak Source Type: research

Factors to Consider When Interpreting the Diagnostic Performance of Fine-Needle Aspiration and Core-Needle Biopsy in a Specific Study Population
Yonsei Med J. 2021 Apr;62(4):374-375. doi: 10.3349/ymj.2021.62.4.374.NO ABSTRACTPMID:33779094 | PMC:PMC8007426 | DOI:10.3349/ymj.2021.62.4.374 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Dong Gyu Na Source Type: research

Erratum to "LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer" by Byun HJ, et al. (Yonsei Med J 2020; 61(11): 923-934.)
Yonsei Med J. 2021 Apr;62(4):378. doi: 10.3349/ymj.2021.62.4.378.ABSTRACTThis corrects the article on p. 923 in vol. 61, PMID: 33107235.PMID:33779095 | PMC:PMC8007425 | DOI:10.3349/ymj.2021.62.4.378 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Source Type: research

Erratum to "Genetic Analysis of Korean Adult Patients with Nontuberculous Mycobacteria Suspected of Primary Ciliary Dyskinesia Using Whole Exome Sequencing" by Cho EH, et al. (Yonsei Med J 2021; 62(3): 224-230.)
Yonsei Med J. 2021 Apr;62(4):379. doi: 10.3349/ymj.2021.62.4.379.ABSTRACTThis corrects the article on p. 224 in vol. 62, PMID: 33635012.PMID:33779096 | PMC:PMC8007428 | DOI:10.3349/ymj.2021.62.4.379 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Source Type: research

Serological Biomarkers and Indices for the Current Activity and Prognosis of ANCA-Associated Vasculitis: Experience in a Single Centre in Korea
Yonsei Med J. 2021 Apr;62(4):279-287. doi: 10.3349/ymj.2021.62.4.279.ABSTRACTSmall vessel vasculitis is composed of two types of vasculitis based on immune-complex deposits, immune-complex vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) according to the 2012 Chapel Hill Consensus Conferences Nomenclature of Vasculitis. In general, the current disease-states are assessed in three ways in real clinical practice such as activity, damage and functional status. Birmingham vasculitis activity score (BVAS, version 3) and five-factor score were calculated for assessing the cross-sectional activity an...
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Sung Soo Ahn Yong Beom Park Sang Won Lee Source Type: research

Clinical Impact of Natural Killer Group 2D Receptor Expression and That of Its Ligand in Ovarian Carcinomas: A Retrospective Study
CONCLUSION: High expression of ULBP1 predicts a better prognosis for HGSC, suggesting that ULBP1 expression could be a novel prognostic indicator in this subset of carcinomas.PMID:33779082 | PMC:PMC8007423 | DOI:10.3349/ymj.2021.62.4.288 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 29, 2021 Category: Universities & Medical Training Authors: Gee Hoon Lee Hee Jung An Tae Hoen Kim Gwangil Kim Kyung Soon Park Hyun Park Tae Ho Lee Ah Young Kwon Source Type: research