Critical and Challenging Issues in the Surgical Management of Low-Lying Rectal Cancer.
Abstract Despite innovative advancements, the management of distally located rectal cancer (RC) remains a formidable endeavor. The critical location of the tumor predisposes it to a circumferential resection margin that tends to involve the sphincters and surrounding organs, pelvic lymph node metastasis, and anastomotic complications. In this regard, colorectal surgeons should be aware of issues beyond the performance of total mesorectal excision (TME). For decades, abdominoperineal resection had been the standard of care for low-lying RC; however, its association with high rates of tumor recurrence, tumor perfora...
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Nacion AJD, Park YY, Yang SY, Kim NK Tags: Yonsei Med J Source Type: research

Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands.
CONCLUSION: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic marker for assessing survival rate in patients with ACC of the salivary glands. PMID: 29978608 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Bazarsad S, Kim JY, Zhang X, Kim KY, Lee DY, Ryu MH, Kim J Tags: Yonsei Med J Source Type: research

Synergistic Anti-Cancer Effects of AKT and SRC Inhibition in Human Pancreatic Cancer Cells.
CONCLUSION: Combined targeting of AKT and SRC resulted in a synergistic efficacy against human pancreatic cancer growth and metastasis. PMID: 29978609 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Ahn K, O YM, Ji YG, Cho HJ, Lee DH Tags: Yonsei Med J Source Type: research

Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3 β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model.
This study investigated the mechanism of the cardioprotective effects of EVs derived from hypoxia-preconditioned human mesenchymal stem cells (MSCs). MATERIALS AND METHODS: EV solutions (0.4 μg/μL) derived from normoxia-preconditioned MSCs (EV(NM)) and hypoxia-preconditioned MSCs (EV(HM)) were delivered in a rat IR injury model. Successful EV delivery was confirmed by the detection of PKH26 staining in hearts from EV-treated rats. RESULTS: EV(HM) significantly reduced infarct size (24±2% vs. 8±1%, p
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Park H, Park H, Mun D, Kang J, Kim H, Kim M, Cui S, Lee SH, Joung B Tags: Yonsei Med J Source Type: research

mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas.
CONCLUSION: Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basis for the management of PTC with negative WBS using ¹⁸F-FDG PET scans. In addition, higher expression of SLC5A5 mRNA was associated with less PTC recurrence, but not with deaths. PMID: 29978611 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Suh S, Kim YH, Goh TS, Jeong DC, Lee CS, Jang JY, Cha W, Han ME, Kim SJ, Kim IJ, Pak K Tags: Yonsei Med J Source Type: research

Increased Thrombogenicity in Chronic Renal Failure in a Rat Model Induced by 5/6 Ablation/Infarction.
CONCLUSION: Our study demonstrated that thrombogenicity is increased in rats with CRF. An activated extrinsic coagulation pathway may play an important role in increasing thrombogenicity in CRF. PMID: 29978612 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Song TJ, Kwon I, Piao H, Lee JE, Han KR, Chang Y, Oh HJ, Choi HJ, Lee KY, Kim YJ, Han KH, Heo JH Tags: Yonsei Med J Source Type: research

Exploring the Key Genes and Pathways of Osteoarthritis in Knee Cartilage in a Rat Model Using Gene Expression Profiling.
CONCLUSION: The results of the present study provide a comprehensive understanding of the roles of DEGs in knee cartilage in relation to the development of OA. PMID: 29978613 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Ren YM, Zhao X, Yang T, Duan YH, Sun YB, Zhao WJ, Tian MQ Tags: Yonsei Med J Source Type: research

CT-based Navigation System Using a Patient-Specific Instrument for Femoral Component Positioning: An Experimental in vitro Study with a Sawbone Model.
CONCLUSION: The CT-based navigation system with PSI was more accurate and consistent than the conventional technique for assessment of stem position. Therefore, it can be used to reduce the frequency of incorrect assessments of the stem position among surgeons and to help with accurate determination of stem anteversion. PMID: 29978614 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Lee S, Kim JY, Hong J, Baek SH, Kim SY Tags: Yonsei Med J Source Type: research

Incidence of Cerebral Palsy in Korea and the Effect of Socioeconomic Status: A Population-Based Nationwide Study.
CONCLUSION: CP incidence in Korea has decreased over the last five years, despite an increase in high-risk deliveries. Income level had no effect in CP incidence. These results may aid CP management and prevention policies. PMID: 29978615 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Kim SW, Jeon HR, Shin JC, Youk T, Kim J Tags: Yonsei Med J Source Type: research

Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects.
CONCLUSION: This is the first study to investigate the association of rs3910105 in SNCA with DAT availability. rs3910105 had an effect on DAT availability, and the correlation between DAT availability and SNCA transcripts were significant in CT genotypes of rs3910105. PMID: 29978616 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Seo Y, Pak K, Nam HY, Seok JW, Lee MJ, Kim EJ, Lee JM, Kim SJ, Kim IJ Tags: Yonsei Med J Source Type: research

Correction of Eyes and Lip Canting after Bimaxillary Orthognathic Surgery.
Abstract Patients who have a lower facial asymmetry with compensatory head posture (developmental facial asymmetry) may have minor temporomandibular (T-M) joint problems and tend to mask their asymmetry by tilting the head for camouflage of their chin deviation. However, this compensatory head posture can give the impression of orbital dystopia and c spine deviation. When these patients undergo bimaxillary orthognathic surgery, orbital canting and head tilting improves gradually without the need for camouflage, and bleary eyes become clearer. We evaluated 13 patients who underwent LeFort I osteotomy combined with ...
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Yang CE, Bae JY, Lee J, Lew DH Tags: Yonsei Med J Source Type: research

First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea.
We report the first case of a genetically confirmed patient with ULD in Korea. PMID: 29978618 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Kim KH, Song JS, Park CW, Ki CS, Heo K Tags: Yonsei Med J Source Type: research

Pathologically Confirmed Cerebral Amyloid Angiopathy with No Radiological Sign in a Patient with Early Onset Alzheimer's Disease.
Abstract Cerebral amyloid angiopathy (CAA) is associated with perivascular disruption, which is caused by progressive amyloid-beta (Aβ) deposition in vessels. Previous autopsy studies have shown that the prevalence of CAA in Alzheimer's disease (AD) is 70% to 90%. CAA is principally characterized by restricted lobar microbleeds (MBs), which can be detected by gradient-echo T2* (GRE) and susceptibility-weighted imaging (SWI). We herein report on a 62-year-old man who presented with 8 years of memory impairment. The apolipoprotein E (APOE) genotype was ε4/ε4, and a brain GRE performed 28 months ...
Source: Yonsei Medical Journal - July 7, 2018 Category: Universities & Medical Training Authors: Kim SJ, Seo Y, Kim HJ, Na DL, Seo SW, Kim Y, Suh YL Tags: Yonsei Med J Source Type: research

Treatment of Oligometastatic Hormone-Sensitive Prostate Cancer: A Comprehensive Review.
Abstract With advancements in diagnostic techniques, including molecular and clinical imaging, that directly target cancer cells, oligometastatic prostate cancer (PCa) is being diagnosed in patients who were, in the past, considered to have localized disease. With accumulating evidence, there has been a paradigm shift in considering aggressive treatments targeted at both the primary tumor and metastatic lesions in an aim to avoid and delay the need for palliative treatments and, ultimately, to achieve survival benefits. However, many questions still remain unanswered regarding the understanding of oligometastatic ...
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Koo KC, Dasgupta P Tags: Yonsei Med J Source Type: research

Impact of Early Salvage Androgen Deprivation Therapy in Localized Prostate Cancer after Radical Prostatectomy: A Propensity Score Matched Analysis.
CONCLUSION: Early sADT after RP improved DPFS and DMFS. Furthermore, early sADT patients demonstrated better CSS in non-organ confined PCa. PMID: 29869455 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Park JW, Jang WS, Koh DH, Ham WS, Rha KH, Hong SJ, Choi YD Tags: Yonsei Med J Source Type: research

CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer.
CONCLUSION: This study suggests that methylation of Wnt pathway genes, in addition to known CpG island methylator phenotype markers, may help predict treatment outcome and survival in patients with CRC. PMID: 29869456 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Kim SH, Park KH, Shin SJ, Lee KY, Kim TI, Kim NK, Rha SY, Ahn JB Tags: Yonsei Med J Source Type: research

A Tumor-Specific Tissue-Penetrating Peptide Enhances the Efficacy of Chemotherapy Drugs in Gastric Cancer.
CONCLUSION: These results demonstrated that co-administration of the novel peptide GXC with chemotherapeutic agents may be a potential way to enhance the efficacy of anticancer drugs in GC treatment. PMID: 29869457 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Jin Z, Wang P, Chen J, He L, Xiao L, Yong K, Deng S, Zhou L Tags: Yonsei Med J Source Type: research

Five-Year Outcomes of Successful Percutaneous Coronary Intervention with Drug-Eluting Stents versus Medical Therapy for Chronic Total Occlusions.
CONCLUSION: In this study, successful CTO PCI with DESs was associated with a higher risk of repeat PCI for the target vessel, but showed a reduced incidence of death or MI. PMID: 29869458 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Rha SW, Choi BG, Baek MJ, Ryu YG, Li H, Choi SY, Byun JK, Mashaly A, Park Y, Jang WY, Kim W, Choi JY, Park EJ, Na JO, Choi CU, Lim HE, Kim EJ, Park CG, Seo HS, Oh DJ Tags: Yonsei Med J Source Type: research

Bone Marrow Mononuclear Cells Transfer for Patients after ST-Elevated Myocardial Infarction: A Meta-Analysis of Randomized Control Trials.
This study sought to analyze the efficacy of treatment with intracoronary bone marrow mononuclear cells (BMMC) on left ventricular (LV) function and remodeling and LV diastolic and systolic function in patients with STEMI. MATERIALS AND METHODS: Literature search of PubMed and EMBASE databases between 2004 and 2017 was performed for randomized controlled trials in STEMI patients who underwent successful percutaneous coronary intervention and received intracoronary BMMC therapy. The defined end points were left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), and left ventricular end...
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Zhang J, Lin L, Zong W Tags: Yonsei Med J Source Type: research

Randomized Comparison of Strut Coverage between Ticagrelor and Clopidogrel in Acute Myocardial Infarction at 3-Month Optical Coherence Tomography.
This study aimed to compare the effects of ticagrelor and clopidogrel on early neointimal healing assessed with optical coherence tomography (OCT) after drug-eluting stent (DES) implantation in patients with acute myocardial infarction (AMI). MATERIALS AND METHODS: AMI patients were randomly assigned to either the ticagrelor or clopidogrel arm. After DES implantation, OCT was performed to assess the percentages of uncovered struts immediately after procedure and 3 months later. RESULTS: Due to early termination, 83 patients out of 106 initially enrolled patients (24% of planned participants) underwent 3-month OCT...
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Kim C, Kim BK, Hong SJ, Ahn CM, Kim JS, Ko YG, Choi D, Hong MK, Jang Y Tags: Yonsei Med J Source Type: research

Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.
CONCLUSION: H. pylori may affect the expression of MUC5AC, MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH₄⁺, but not E-cadherin. PMID: 29869461 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Zhang X, Shi D, Liu YP, Chen WJ, Wu D Tags: Yonsei Med J Source Type: research

Effects and Predictive Factors of Immunosuppressive Therapy Combined with Umbilical Cord Blood Infusion in Patients with Severe Aplastic Anemia.
Abstract PURPOSE: To investigate the efficacy and safety of umbilical cord blood (UCB) infusion (UCBI) plus immunosuppressive therapy (IST) treatment in comparison to IST treatment, as well as predictive factors for clinical responses, in severe aplastic anemia (SAA) patients. MATERIALS AND METHODS: Totally, 93 patients with SAA were enrolled in this cohort study. In the IST group, rabbit antithymocyte globulin (r-ATG) combined with cyclosporine A (CsA) was administered, while in the IST+UBCI group, r-ATG, CsA, and UCB were used. RESULTS: After 6 months of treatment, UCBI+IST achieved a higher complete r...
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Zhang X, Li Z, Geng W, Song B, Wan C Tags: Yonsei Med J Source Type: research

A New Integrated Newborn Screening Workflow Can Provide a Shortcut to Differential Diagnosis and Confirmation of Inherited Metabolic Diseases.
CONCLUSION: This integrated diagnostic workflow resulted in a high yield. This approach not only enabled early confirmation of specific IMD, but also detected conditions not included in the current NBS. PMID: 29869463 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Ko JM, Park KS, Kang Y, Nam SH, Kim Y, Park I, Chae HW, Lee SM, Lee KA, Kim JW Tags: Yonsei Med J Source Type: research

Comparison of the PANArray HPV Genotyping Chip Test with the Cobas 4800 HPV and Hybrid Capture 2 Tests for Detection of HPV in ASCUS Women.
CONCLUSION: Results classified as 'HPV-other' type by the PANArray HPV test, or gray zone results by HC2 (RLU/CO ratio level 1-10) should be carefully interpreted using comprehensive clinical information. PMID: 29869464 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Ki EY, Lee YK, Lee A, Park JS Tags: Yonsei Med J Source Type: research

Common Upper Extremity Disorders and Function Affect Upper Extremity-Related Quality of Life: A Community-Based Sample from Rural Areas.
CONCLUSION: Epicondylitis significantly affected QOL, while other UEMDs, such as hand osteoarthritis and rotator cuff tear, had no significant impact. When a patient's QOL is affected by a UEMD, there is an increased possibility of the simultaneous presence of other UEMDs. PMID: 29869465 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Moon DK, Park YJ, Song SY, Kim MJ, Park JS, Nam DC, Kim DH, Na JB, Lee SI, Hwang SC, Park KS Tags: Yonsei Med J Source Type: research

Functional Communication Profiles in Children with Cerebral Palsy in Relation to Gross Motor Function and Manual and Intellectual Ability.
CONCLUSION: Very strong relationships were noted among three communication classification systems that are closely related with intellectual ability. Compared to gross motor function, manual ability seemed more closely related with communication function in these children. PMID: 29869466 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Choi JY, Park J, Choi YS, Goh YR, Park ES Tags: Yonsei Med J Source Type: research

Effect of Socioeconomic Status and Underlying Disease on the Association between Ambient Temperature and Ischemic Stroke.
CONCLUSION: Ambient temperature increases above a threshold were positively associated with ED visits for ischemic stroke in patients with diabetes and medical aid beneficiaries in summer. In winter, temperature, to a point, and ischemic stroke visits were inversely associated. PMID: 29869467 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Cho SK, Sohn J, Cho J, Noh J, Ha KH, Choi YJ, Pae S, Kim C, Shin DC Tags: Yonsei Med J Source Type: research

Relationship between Emotional Abuse and Depression among Community-Dwelling Older Adults in Korea.
Abstract Despite recent advances, there is little research on factors associated with emotional abuse among Korean older adults. The present study investigated the relationships between depression and emotional abuse among community-dwelling Korean older adults. We analyzed the dataset from the Survey of Living Conditions and Welfare Needs of Korean Older Persons conducted by the Korea Institute for Health and Social Affairs in 2011. Older adults (aged>65 years, n=10674) were randomly selected. Multivariate logistic regression was used to investigate factors associated with emotional abuse in terms of sociodemo...
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Park JI Tags: Yonsei Med J Source Type: research

Two Korean Families with Limb-Girdle Muscular Dystrophy Type 1D Associated with DNAJB6 Mutations.
Abstract Limb-girdle muscular dystrophies (LGMD) are heterogeneous disorders with autosomal inheritance. Autosomal dominant LGMD mapped to 7q36.3 has been classified as LGMD type 1D (LGMD1D) in the Human Gene Nomenclature Committee Database. LGMD1D is characterized predominantly by limb-girdle weakness and may also show a bulbar symptom in some cases. In the past, the frequency of this disease was uncommon, and this disorder was mainly found in Europe and the United States. However, recently, this disorder has been reported in Asia, including Japan, Korea, and Taiwan. Here, we report on three LGMD1D patients, incl...
Source: Yonsei Medical Journal - June 6, 2018 Category: Universities & Medical Training Authors: Kim K, Park HJ, Lee JH, Hong J, Ahn SW, Choi YC Tags: Yonsei Med J Source Type: research

Moonlighting Activity of Secreted Inflammation-Regulatory Proteins.
Abstract Moonlighting proteins exhibit multiple activities in different cellular compartments, and their abnormal regulation could play an important role in many diseases. To date, many proteins have been identified with moonlighting activity, and more such proteins are being gradually identified. Among the proteins that possess moonlighting activity, several secreted proteins exhibit multiple activities in different cellular locations, such as the extracellular matrix, nucleus, and cytoplasm. While acute inflammation starts rapidly and generally disappears in a few days, chronic inflammation can last for months o...
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Yoon JH, Ryu J, Baek SJ Tags: Yonsei Med J Source Type: research

Plasma Cell-Free DNA as a Predictive Marker after Radiotherapy for Hepatocellular Carcinoma.
CONCLUSION: Quantitative analysis of cfDNA was feasible in our cohorts. Post-RT cfDNA levels were negatively correlated with treatment outcomes, indicating the potential for the use of post-RT cfDNA levels as an early predictor of treatment responses and LC after RT for HCC patients. PMID: 29749129 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Park S, Lee EJ, Rim CH, Seong J Tags: Yonsei Med J Source Type: research

Effects of Coronary Artery Revascularization with a Polymer-Free Biolimus A9-Coated BioFreedom Stent Versus Bypass Surgery before Noncardiac Surgery.
CONCLUSION: This study demonstrated that BioFreedom stenting as a revascularization strategy before major noncardiac surgery might be feasible and safe in selected patients with less severe coronary artery diseases. PMID: 29749130 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Kim K, Kim C, Kim BK, Jang JY, Her AY, Kim S, Hong SJ, Ahn CM, Kim JS, Ko YG, Choi D, Hong MK, Jang Y Tags: Yonsei Med J Source Type: research

The Impact of Prediabetes on Two-Year Clinical Outcomes in Patients Undergoing Elective Percutaneous Coronary Intervention.
Abstract PURPOSE: Prediabetes is an independent risk factor for cardiovascular disease. However, data on the long term adverse clinical outcomes of prediabetic patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) are scarce. MATERIALS AND METHODS: The study population comprised 674 consecutive non-diabetic patients who underwent elective PCI between April 2007 and November 2010. Prediabetes was defined as hemoglobin A1c (HbA1c) of 5.7% to 6.4%. Two-year cumulative clinical outcomes of prediabetic patients (HbA1c of 5.7% to 6.4%, n=242) were compared with those of a normoglycemic group (
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Choi WG, Rha SW, Choi BG, Choi SY, Byun JK, Mashaly A, Park Y, Jang WY, Kim W, Choi JY, Park EJ, Na JO, Choi CU, Kim EJ, Park CG, Seo HS Tags: Yonsei Med J Source Type: research

Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis.
CONCLUSION: The present study confirmed that miRNA 133a, which was associated with high mortality in CAD patients, holds prognostic value in CAD. More importantly, this study corrected issues raised against a prior meta-analysis and provides accurate information. PMID: 29749132 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Kim JS, Pak K, Goh TS, Jeong DC, Han ME, Kim J, Oh SO, Kim CD, Kim YH Tags: Yonsei Med J Source Type: research

Characteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea.
CONCLUSION: Recent advances in CT technology were leveraged to provide accurate characteristics of AIs and to detect smaller ACCs. PMID: 29749133 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Ahn SH, Kim JH, Baek SH, Kim H, Cho YY, Suh S, Kim BJ, Hong S, Koh JM, Lee SH, Song KH Tags: Yonsei Med J Source Type: research

miR-215 Enhances HCV Replication by Targeting TRIM22 and Inactivating NF- κB Signaling.
CONCLUSION: miR-215 facilitated HCV replication via inactivation of the NF-κB pathway by inhibiting TRIM22, providing a novel potential target for HCV infection. PMID: 29749134 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Tian H, He Z Tags: Yonsei Med J Source Type: research

Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population.
CONCLUSION: EBF2 gene variants can contribute to KD in the Korean population. PMID: 29749135 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Bae Y, Shin D, Nam J, Lee HR, Kim JS, Kim KY, Kim DS, Chung YJ Tags: Yonsei Med J Source Type: research

Minimally Invasive Lumbar Spinal Fusion Is More Effective Than Open Fusion: A Meta-Analysis.
Abstract PURPOSE: To evaluate the efficacy of minimally invasive spinal fusion in comparison to open fusion for adult lumbar spondylolisthesis or spondylosis. MATERIALS AND METHODS: The present study was conducted as a meta-analysis of all estimates from studies that were selected after comprehensive literature search by two independent reviewers. RESULTS: Of 745 articles, nine prospective cohort studies were identifed. The quality of evidence was downgraded because of study design, inconsistency, imprecision, and publication bias. Greater Oswestry Disability Index score improvement [weighted mean differ...
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Park Y, Seok SO, Lee SB, Ha JW Tags: Yonsei Med J Source Type: research

The Effect of Diagnosis-Related Group Payment System on Quality of Care in the Field of Obstetrics and Gynecology among Korean Tertiary Hospitals.
Abstract PURPOSE: To examine changes in clinical practice patterns following the introduction of diagnosis-related groups (DRGs) under the fee-for-service payment system in July 2013 among Korean tertiary hospitals and to evaluate its effect on the quality of hospital care. MATERIALS AND METHODS: Using the 2012-2014 administrative database from National Health Insurance Service claim data, we reviewed medical information for 160400 patients who underwent cesarean sections (C-secs), hysterectomies, or adnexectomies at 43 tertiary hospitals. We compared changes in several variables, including length of stay, sp...
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Jung YW, Pak H, Lee I, Kim EH Tags: Yonsei Med J Source Type: research

Estimation of Standard Liver Volume Using CT Volume, Body Composition, and Abdominal Geometry Measurements.
CONCLUSION: SLV estimation formulas using gender-balanced measurements showed better performance than those using gender-unbalanced measurements. Inclusion of body composition and abdominal geometry variables contributed to improved performance of SLV estimation. PMID: 29749138 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Yang X, Yang JD, Lee S, Hwang HP, Ahn S, Yu HC, You H Tags: Yonsei Med J Source Type: research

Physical Inactivity and Unhealthy Metabolic Status Are Associated with Decreased Natural Killer Cell Activity.
Abstract PURPOSE: Several studies have reported relationships among physical activity, healthy metabolic status, and increased natural killer (NK) cell activity. However, large-scale data thereon are lacking. Thus, the present study aimed to assess NK cell activity according to physical activity and metabolic status. MATERIALS AND METHODS: A cross-sectional study was performed on 12014 asymptomatic examinees. Using a patented stimulatory cytokine, NK cell activity was quantitated by the amount of interferon-γ secreted into the plasma by NK cells. Physical activity levels were assessed using the validate...
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Jung YS, Park JH, Park DI, Sohn CI, Lee JM, Kim TI Tags: Yonsei Med J Source Type: research

Increased Uptake of AV-1451 in a Subacute Infarction Lesion.
Abstract ¹⁸F-AV-1451 is a tau PET ligand that has high affinity for paired helical filament tau. However, various off-target bindings unrelated to tau have also been reported. Herein, we report a case of 83-year-old woman, who showed abnormal uptake of AV-1451 that was shown to be subacute infarction. Clinicians should recognize that increased uptake of AV-1451 may be related to stroke. PMID: 29749140 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 13, 2018 Category: Universities & Medical Training Authors: Cho SH, Cho H, Park S, Ryu YH, Choi JY, Lyoo CH, Na DL, Seo SW, Kim HJ Tags: Yonsei Med J Source Type: research

An Emerging Role for Circular RNAs in Osteoarthritis.
Abstract Circular RNAs (circRNAs) are currently classed as non-coding RNAs that, unlike the better known canonical linear RNAs, form a covalently closed continuous loop without 5' or 3' polarities. With the development of high throughput sequencing technology, a large number of circRNAs have been discovered in many species. More importantly, growing evidence suggests that circRNAs are abundant, evolutionally conserved, and relatively stable in cells and tissues. Strikingly, recent studies have discovered that circRNAs can serve as microRNA sponges, interact with RNA-binding protein, and regulate gene transcription...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Yu CX, Sun S Tags: Yonsei Med J Source Type: research

Trends in Blood Pressure and Prevalence of Hypertension in Korean Adults Based on the 1998-2014 KNHANES.
Abstract PURPOSE: To investigate trends in blood pressure (BP) and hypertension prevalence in Korea. MATERIALS AND METHODS: Based on the Korean National Health and Nutrition Examination Survey (KNHANES) I (1998), II (2001), III (2005), IV (2007-2009), V (2010-2012), and VI (2013-2014), 56077 participants (23974 men and 32103 women) were included. RESULTS: Mean systolic BP (SBP) and diastolic BP (DBP) decreased in both sexes (male SBP: 128.1 to 120.2 mm Hg, male DBP: 82.0 to 78.5 mm Hg; female SBP: 125.7 to 116.0 mm Hg and female DBP: 77.4 to 73.2 mm Hg from the KNHANES I-VI). The age-standardized prevale...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Kim TJ, Lee JW, Kang HT, Cho MC, Lim HJ, Kim JY, Bae JW, Lee YJ, Lee SH, Linton JA, Kim Y Tags: Yonsei Med J Source Type: research

Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation.
CONCLUSION: Increased L-arginine levels following limonin-dependent arginase inhibition prohibited NADPH oxidase activation in a PKCβII-dependent manner, and blocked nLDL-stimulated VSMC proliferation. PMID: 29611398 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S Tags: Yonsei Med J Source Type: research

Effect of Central Line Bundle Compliance on Central Line-Associated Bloodstream Infections.
CONCLUSION: This study provides direct evidence that completing all CL bundle components perfectly is essential for preventing CLABSIs. Customized education should be provided, according to specific weaknesses of bundle performance. PMID: 29611399 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Lee KH, Cho NH, Jeong SJ, Kim MN, Han SH, Song YG Tags: Yonsei Med J Source Type: research

Real World Experience of Telbivudine Versus Entecavir in Patients with Chronic Hepatitis B, Including Long-Term Outcomes after Treatment Modification.
CONCLUSION: During the 3-year study, there were no significant differences in the CVR between the ETV and LdT groups if appropriate rescue therapy was considered. PMID: 29611400 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Choi JW, Kim SH, Seo JH, Cho YS, Won SY, Park BK, Jeon HH, Lee YK, Lee CK Tags: Yonsei Med J Source Type: research

Low-Dose Unenhanced Computed Tomography with Iterative Reconstruction for Diagnosis of Ureter Stones.
Abstract PURPOSE: To study the clinical application of low-dose unenhanced computed tomography with iterative reconstruction technique (LDCT-IR) on renal colic in the emergency department. MATERIALS AND METHODS: We conducted a prospective, single-blinded, randomized, and non-inferiority study. From March 2014 to August 2015, 112 patients with renal colic were included, and were randomized to either LDCT-IR (n=46) or standard-dose unenhanced CT (SDCT) (n=66) groups. The accuracy of urolithiasis diagnosis was the primary endpoint of this study. Radiation dose, size and location of the stone, hydronephrosis, oth...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Chi BH, Chang IH, Lee DH, Park SB, Kim KD, Moon YT, Huh TK Tags: Yonsei Med J Source Type: research

Delta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse in ANCA-Associated Vasculitis.
CONCLUSION: DNI could reflect BVAS at diagnosis and furthermore, DNI ≥0.65% could not only identify severe AAV at diagnosis, but also predict relapse during the follow-up in patients with GPA and MPA. PMID: 29611402 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Yoo J, Ahn SS, Jung SM, Song JJ, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods.
CONCLUSION: Our results suggest that ICV and IV injections of pMSCs facilitate the recovery of cholinergic neuronal populations and cognitive behavior. This recovery likely occurs through paracrine effects that resemble microglia function rather than direct differentiation of injected pMSCs into cholinergic neurons. PMID: 29611403 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW Tags: Yonsei Med J Source Type: research