Log in to search using one of your social media accounts:

 

Dr. Myung-Sun Kim (1897-1982): An Eternal Teacher of Yonsei University.
PMID: 29436182 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Ahn DS Tags: Yonsei Med J Source Type: research

Dr. Charles Inglis McLaren (1882-1957): A Psychiatrist who Treated the Korean Soul.
PMID: 29436183 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Yeo IS Tags: Yonsei Med J Source Type: research

Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases.
Abstract Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect against them is to develop vaccines in advance. Systems biology approaches provide an integrative way to understand the complex immune response to pathogens. They can lead to a greater understanding of EID pathogenesis and facilitate the evaluation of newly developed vaccine-induced immunity in a timely manner. In recent years, advances in high throughput technologies have enabled researchers to successfully apply syst...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Oh SJ, Choi YK, Shin OS Tags: Yonsei Med J Source Type: research

Emotional Labor and Burnout: A Review of the Literature.
Abstract This literature review was conducted to investigate the association between emotional labor and burnout and to explore the role of personality in this relationship. The results of this review indicate that emotional labor is a job stressor that leads to burnout. Further examination of personality traits, such as self-efficacy and type A behavior pattern, is needed to understand the relationships between emotional labor and health outcomes, such as burnout, psychological distress, and depression. The results also emphasized the importance of stress management programs to reduce the adverse outcomes of emot...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jeung DY, Kim C, Chang SJ Tags: Yonsei Med J Source Type: research

Hypofractionated Re-irradiation after Maximal Surgical Resection for Recurrent Glioblastoma: Therapeutic Adequacy and Its Prognosticators of Survival.
CONCLUSION: HFReRT after maximal surgery prolonged survival in selected patients with recurrent GBM, especially those with small-sized recurrences in non-eloquent areas and good performance. PMID: 29436186 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Lee J, Ahn SS, Chang JH, Suh CO Tags: Yonsei Med J Source Type: research

Efficacy of Pemetrexed-based Chemotherapy in Comparison to Non-Pemetrexed-based Chemotherapy in Advanced, ALK+ Non-Small Cell Lung Cancer.
Abstract PURPOSE: Previous retrospective studies suggest that anaplastic lymphoma kinase (ALK) mutation-positive (ALK+) non-small cell lung cancer (NSCLC) patients are sensitive to pemetrexed. To determine its efficacy, we retrospectively evaluated clinical outcomes of pemetrexed-based chemotherapy in patients with ALK+ NSCLC. MATERIALS AND METHODS: We identified 126 patients with advanced, ALK+ NSCLC who received first-line cytotoxic chemotherapy. We compared response, progression-free survival (PFS), and overall survival (OS) rates according to chemotherapy regimens. Furthermore, we evaluated intracranial t...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jo J, Kim SH, Kim YJ, Lee J, Kim M, Keam B, Kim TM, Kim DW, Heo DS, Chung JH, Jeon YK, Lee JS Tags: Yonsei Med J Source Type: research

Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis.
CONCLUSION: We demonstrated that PNA clamping has a higher sensitivity than DS for detecting oncogenic alterations in NSCLC. Our findings suggest that PNA clamping is a more useful method for clinical practice. PMID: 29436188 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Song JU, Lee J Tags: Yonsei Med J Source Type: research

Prostate-Specific Antigen Kinetics Following 5 α-Reductase Inhibitor Treatment May Be a Useful Indicator for Repeat Prostate Biopsy.
CONCLUSION: The effects of 5ARIs on prostate cancer detection and chemoprevention remain uncertain. However, more than two increases in PSA level after 6 months of 5ARI treatment may indicate the presence of prostate cancer. PMID: 29436189 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Heo JE, Koo KC, Hong SJ, Park SU, Chung BH, Lee KS Tags: Yonsei Med J Source Type: research

Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression.
CONCLUSION: TUG1 facilitated proliferation and suppressed apoptosis by regulating the miR-132-3p/SOX4 axis in human OS cell lines and primary OS cells. This finding provides a potential target for OS therapy. PMID: 29436190 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Li G, Liu K, Du X Tags: Yonsei Med J Source Type: research

CHA ₂DS₂-VASc Score in the Prediction of Ischemic Stroke in Patients after Radiofrequency Catheter Ablation of Typical Atrial Flutter.
This study investigates whether CHA₂DS₂-VASc score is useful for predicting ischemic stroke after successful ablation of typical AFL. MATERIALS AND METHODS: A total of 293 patients (236 men, mean age 56.1±13.5 years) who underwent successful radiofrequency catheter ablation for typical AFL were included in this study. The clinical end point was occurrence of ischemic stroke during follow-up after AFL ablation. RESULTS: During the follow-up period (60.8±45.9 months), ischemic stroke occurred in 18 (6%) patients at a median of 34 months (interquartile range, 13-65 months). CHA₂DS₂-VASc score [...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jin MN, Song C, Kim TH, Uhm JS, Pak HN, Lee MH, Joung B Tags: Yonsei Med J Source Type: research

Effects of Physician Volume on Readmission and Mortality in Elderly Patients with Heart Failure: Nationwide Cohort Study.
CONCLUSION: Physician volume is related to lower readmission and mortality for heart failure. Of interest, 30-day readmission and 1-year mortality were significantly associated with the combined effects of physician and institution bed volume. PMID: 29436192 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Lee JE, Park EC, Jang SY, Lee SA, Choy YS, Kim TH Tags: Yonsei Med J Source Type: research

Coronary Flow Reserve in Non-Infarcted Myocardium Predicts Long-Term Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention.
Abstract PURPOSE: Coronary flow reserve (CFR) is recognized as an indicator of myocardial perfusion. The aim of this study was to assess the relationship between CFR in the non-infarcted myocardium and the incidence of major adverse cardiac events (MACEs). MATERIALS AND METHODS: 100 consecutive patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) were enrolled in the present study, and divided into MACE and non-MACE groups according to the incidence of 12-month MACEs. Left ventricular function and CFR were analyzed using two-dimensional echocardiography and myoca...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Cheng R, Zhu X, Li Y, Bai X, Xue L, Wei L Tags: Yonsei Med J Source Type: research

Comparison of Rhythm and Rate Control Strategies for Stroke Occurrence in a Prospective Cohort of Atrial Fibrillation Patients.
Abstract PURPOSE: Comparisons of rhythm and rate control strategies for stroke prevention in patients with atrial fibrillation (AF) are still inconclusive. We compared differences in clinical outcomes between the rhythm and rate control strategies. MATERIALS AND METHODS: The COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry prospectively enrolled 6000 patients who were treated for AF using real-world guideline adherence at multiple referral centers. In total, 2508 (41.8%) patients were clinically followed up for over six months. Of these, 1134 ...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Choi YJ, Kang KW, Kim TH, Cha MJ, Lee JM, Park J, Park JK, Shim J, Uhm JS, Kim J, Park HW, Choi EK, Kim JB, Kim C, Lee YS, Joung B Tags: Yonsei Med J Source Type: research

Impact of Ambulatory Blood Pressure on Early Cardiac and Renal Dysfunction in Hypertensive Patients without Clinically Apparent Target Organ Damage.
Abstract PURPOSE: Impaired left ventricular (LV) global longitudinal strain (GLS) and the presence of microalbuminuria indicate early cardiac and renal dysfunction. We aimed to determine the relationships among 24-h ambulatory blood pressure (BP) variables, LV GLS, and urine albumin creatinine ratio (UACR) in hypertensive patients. MATERIALS AND METHODS: A total of 130 hypertensive patients (mean age 53 years; 59 men) underwent 24-h ambulatory BP monitoring, measurements of peripheral and central BPs, and transthoracic echocardiography. Patients with apparent LV systolic dysfunction (LV ejection fraction
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim D, Shim CY, Hong GR, Park S, Cho IJ, Chang HJ, Ha JW, Chung N Tags: Yonsei Med J Source Type: research

Predictors of Long-Term Outcomes of Percutaneous Mitral Valvuloplasty in Patients with Rheumatic Mitral Stenosis.
Abstract PURPOSE: We determined factors associated with long-term outcomes of patients who underwent successful percutaneous mitral balloon valvuloplasty (PMV). MATERIALS AND METHODS: Between August 1980 and May 2013, 1187 patients underwent PMV at Severance Hospital, Seoul, Korea. A total of 742 patients who underwent regular clinic visits for more than 10 years were retrospectively analyzed. The endpoints consisted of repeated PMV, mitral valve (MV) surgery, and cardiovascular-related death. RESULTS: The optimal result, defined as a post-PMV mitral valve area (MVA)>1.5 cm² and mitral regurgitat...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim D, Chung H, Nam JH, Park DH, Shim CY, Kim JS, Chang HJ, Hong GR, Ha JW Tags: Yonsei Med J Source Type: research

The Role of Serotonin in Ventricular Repolarization in Pregnant Mice.
CONCLUSION: Serotonin increases repolarizing currents by augmenting Kv currents. Elevated serotonin levels during pregnancy counterbalance pregnancy-related QT prolongation by facilitating Htr3-mediated Kv currents. PMID: 29436197 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B Tags: Yonsei Med J Source Type: research

Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study.
Abstract PURPOSE: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population-based prospective study. MATERIALS AND METHODS: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population-based cohort study who were examined from 2005-2008 (baseline) and from 2...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Choi JR, Kim JY, Park IH, Huh JH, Kim KW, Cha SK, Park KS, Sohn JH, Park JT, Koh SB Tags: Yonsei Med J Source Type: research

Red Blood Cell Distribution Width Can Predict Vasculitis Activity and Poor Prognosis in Granulomatosis with Polyangiitis.
CONCLUSION: RDW predicts vasculitis activity in GPA, and RDW ≥15.4% at diagnosis may increase the risk of severe GPA at diagnosis and predict refractory diseases during follow-up. PMID: 29436199 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim HJ, Yoo J, Jung SM, Song JJ, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

Digital Videoscopic Retrograde Intrarenal Surgeries for Renal Stones: Time-to-Maximal Stone Length Ratio Analysis.
CONCLUSION: Low MSDs and the last 50 cases were significant predictors of stone-free rate in videoscopic RIRS. PMID: 29436200 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jeong JY, Kim JC, Kang DH, Lee JY Tags: Yonsei Med J Source Type: research

Infarct Core Expansion on Computed Tomography before and after Intravenous Thrombolysis.
Abstract PURPOSE: Infarct core can expand rapidly in acute stroke patients receiving intravenous tissue plasminogen activator (IV t-PA). We investigated changes in the extent of infarct core during IV t-PA treatment, and explored the associative factors of this infarct core expansion in patients with proximal artery occlusion. MATERIALS AND METHODS: We included patients who were considered for sequential intra-arterial therapy (IAT) due to occlusion of intracranial proximal artery after IV t-PA. Patients who had a baseline Alberta Stroke Program Early Computed Tomography (CT) Score (ASPECTS) ≥6 and who und...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Song D, Yoo J, Baek JH, Kim J, Lee HS, Kim YD, Nam HS, Heo JH Tags: Yonsei Med J Source Type: research

Prevalence of Frailty in Patients with Osteoporotic Vertebral Compression Fracture and Its Association with Numbers of Fractures.
Abstract PURPOSE: To assess the association between frailty and osteoporotic vertebral compression fracture (OVCF) and to evaluate the relationship between numbers of OVCFs and frailty. MATERIALS AND METHODS: We enrolled 760 subjects, including 59 patients (with OVCF) and 701 controls (without OVCF). Successful matching provided 56 patient-control pairs. We analyzed principal clinical and demographic information, which included sex, age, height, weight, body mass index (BMI), variable frailty phenotypes, and Oswestry Disability Index (ODI) and EuroQol 5-dimension questionnaire (EQ-5D) scores. The association ...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim HJ, Park S, Park SH, Park J, Chang BS, Lee CK, Yeom JS Tags: Yonsei Med J Source Type: research

Development of a Gustatory Function Test for Clinical Application in Korean Subjects.
CONCLUSION: This gustatory function test was easy to perform, affordable, and time-saving, with the capacity to self-produce and obtain reliable data. Gustatory function was more sensitive in young people, women, and non-smokers. PMID: 29436203 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Hwang CS, Kim JW, Al Sharhan SS, Kim JW, Cho HJ, Yoon JH, Kim CH Tags: Yonsei Med J Source Type: research

Improvement in Ovarian Tissue Quality with Supplementation of Antifreeze Protein during Warming of Vitrified Mouse Ovarian Tissue.
This study sought to compare AFP treatment protocols: a conventional protocol with AFP treatment during vitrification and first-step warming and a new protocol with AFP treatment during the first-step warming only. According to the protocols, 10 mg/mL of LeIBP (a type of AFP) was used. Five-week-old B6D2F1 mouse ovaries were randomly divided into a vitrified-warmed control and two experimental groups, one treated with the conventional AFP treatment protocol (LeIBP-all) and the other with the new AFP treatment protocol (LeIBP-w). For evaluation, ratios of ovarian follicle integrity, apoptosis, and DNA double-strand (DDS) da...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kong HS, Kim EJ, Youm HW, Kim SK, Lee JR, Suh CS, Kim SH Tags: Yonsei Med J Source Type: research

FAT1 Gene Alteration in Facioscapulohumeral Muscular Dystrophy Type 1.
We describe a 59-year-old woman with both contracted D4Z4 repeat units and a FAT1 mutation. Shoulder girdle muscle weakness developed at the age of 56 years, and was followed by proximal leg weakness. When we examined her at 59 years of age, she displayed asymmetric and predominant weakness of facial and proximal muscles. Muscle biopsy showed increased variation in fiber size and multifocal degenerating fibers with lymphocytic infiltration. Southern blot analysis revealed 8 D4Z4 repeat units, and targeted sequencing of modifier genes demonstrated the c.10331 A>G variant in the FAT1 gene. This FAT1 variant has previously...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Park HJ, Lee W, Kim SH, Lee JH, Shin HY, Kim SM, Park KD, Lee JH, Choi YC Tags: Yonsei Med J Source Type: research

Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene.
We report a case of OS in a 3-year-old Korean girl and its underlying gene mutation. The patient presented with a disabling, bilateral palmoplantar keratoderma with onychodystrophy. She also exhibited pruritic eczematous skin lesions around her eyes, ears and gluteal fold. Genetic analysis identified a heterozygous p.Gly568Val missense mutation in the exon 13 of TRPV3. To our knowledge, this is the first case of OS in the Korean population showing a missense mutation p.Gly573Ser. PMID: 29436206 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Choi JY, Kim SE, Lee SE, Kim SC Tags: Yonsei Med J Source Type: research

Alternative Surgical Methods in Patients with Recurrent Palmar Hyperhidrosis and Compensatory Hyperhidrosis.
Abstract Recurrent hyperhidrosis after thoracic sympathectomy is an uncomfortable condition, and compensatory hyperhidrosis (CH) is one of the most troublesome side effects. Here, we describe two patients with recurrent palmar hyperhidrosis (PH) and CH over the whole body simultaneously. They were treated with bilateral T4 sympathetic clipping and reconstruction of the sympathetic nerve from a T5 to T8 sympathetic nerve graft, which was transferred to the resected T3 sympathetic bed site. They reported improvements in sweating and were fully satisfied with the results. Our method can be considered as an alternativ...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jung HS, Lee DY, Park JS Tags: Yonsei Med J Source Type: research

Preeminent Medical Missionary in the 20th Century: Oliver R. Avison.
PMID: 29214769 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Choi JK Tags: Yonsei Med J Source Type: research

Disruption of the Gut Ecosystem by Antibiotics.
Abstract The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression of each process leads to changes in the intestinal environment. Alterations in microbial communities lead to changes in functional structures based on the metabolites produced in the gut, and these environmental changes result in various bacterial infections and chronic enteric inflammatory d...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Yoon MY, Yoon SS Tags: Yonsei Med J Source Type: research

Detection of Rare Mutations in EGFR-ARMS-PCR-Negative Lung Adenocarcinoma by Sanger Sequencing.
This study aimed to identify potential epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer that went undetected by amplification refractory mutation system-Scorpion real-time PCR (ARMS-PCR). MATERIALS AND METHODS: A total of 200 specimens were obtained from the First Affiliated Hospital of Guangzhou Medical University from August 2014 to August 2015. In total, 100 ARMS-negative and 100 ARMS-positive specimens were evaluated for EGFR gene mutations by Sanger sequencing. The methodology and sensitivity of each method and the outcomes of EGFR-tyrosine kinase inhibitor (TKI) therapy were a...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Liang C, Wu Z, Gan X, Liu Y, You Y, Liu C, Zhou C, Liang Y, Mo H, Chen AM, Zhang J Tags: Yonsei Med J Source Type: research

Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell.
This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible mechanism. MATERIALS AND METHODS: The pancreatic cancer cell line SW1990 was cultured and treated with PAB dose- and time-dependent manners. Cell proliferation and invasion ability were measured by MTT assay and Matrigel/Transwell test, respectively. Semi-quantitative real-time polymerase chain reaction and Western blotting were conducted to detect the expression of EMT markers and the key molecules. Finally, nude mic...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Li X, Zhao X, Song W, Tian Z, Yang L, Niu Q, Zhang Q, Xie M, Zhou B, Xu Y, Wu J, Zhang C Tags: Yonsei Med J Source Type: research

Protective Effects of Female Reproductive Factors on Lauren Intestinal-Type Gastric Adenocarcinoma.
CONCLUSION: These findings support that female sex hormones might be protective against intestinal-type gastric cancer. PMID: 29214773 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Kim SM, Min BH, Lee J, An JY, Lee JH, Sohn TS, Bae JM, Kim JJ, Kang WK, Kim S, Choi MG Tags: Yonsei Med J Source Type: research

Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer.
Abstract PURPOSE: To investigate the association of cancer stem-cell markers [octamer-binding transcription factor 4 (OCT4), sex determining region Y-box 2 (SOX2), and Nanog homebox (NANOG)] expression with clinicopathological properties and overall survival (OS) in operative rectal cancer (RC) patients receiving adjuvant therapy. MATERIALS AND METHODS: 153 patients with primary RC receiving surgery were enrolled. Tumor tissue and paired adjacent normal tissue sample were collected, and OCT4, SOX2, and NANOG expressions were assessed by immunofluorescent staining. The median follow-up duration was 5.2 years, ...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: You L, Guo X, Huang Y Tags: Yonsei Med J Source Type: research

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.
CONCLUSION: TRIM56 may act as a tumor suppressor in MM through activation of TLR3/TRIF signaling pathway, contributing to a better understanding of the molecular mechanism of TRIM56 involvement in MM pathogenesis and providing a promising therapy strategy for patients with MM. PMID: 29214775 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M Tags: Yonsei Med J Source Type: research

14-3-3 ζ Overexpression is Associated with Poor Prognosis in Ovarian Cancer.
CONCLUSION: 14-3-3ζoverexpression might be a potential prognostic biomarker for ovarian cancer, and the inhibition of 14-3-3ζcould be a therapeutic option that enhances the antitumor activity of cisplatin. PMID: 29214776 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Kim HJ, Sung SH, Kim CY, Bae MK, Cho MS, Kim YH, Kim SC, Ju W Tags: Yonsei Med J Source Type: research

Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox.
CONCLUSION: In pooled analysis of data from two Korean HF registries, the high BMI group was independently associated with lower 1-year mortality rate from systolic HF, especially in men. PMID: 29214777 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Hong S, Lee JH, Kim KM, Lee JW, Youn YJ, Ahn MS, Ahn SG, Lee SH, Yoon J, Choe KH, Yoo BS Tags: Yonsei Med J Source Type: research

Supplementary Diagnostic Landmarks of Left Ventricular Non-Compaction on Magnetic Resonance Imaging.
Abstract PURPOSE: Diagnostic criteria for left ventricular non-compaction (LVNC) are still a matter of dispute. The aim of our present study was to test the diagnostic value of two novel diagnostic cardiac magnetic resonance (CMR) parameters: proof of non-compact (NC) myocardium blood flow using T2 sequences and changes in geometry of the left ventricle. MATERIALS AND METHODS: The study included cases with LVNC and controls, from a data base formed in a period of 3.5 years (n=1890 exams), in which CMR protocol included T2 sequences. Measurement of perpendicular maximal and minimal end diastolic dimensions in ...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Boban M, Pesa V, Beck N, Manola S, Zulj M, Rotim A, Vcev A Tags: Yonsei Med J Source Type: research

Effectiveness and Safety of Biolimus A9 ™-Eluting stEnt in Patients with AcUTe Coronary sYndrome; A Multicenter, Observational Study (BEAUTY Study).
CONCLUSION: Our study demonstrated excellent 1-year clinical outcomes of BES implantation in patients at low-risk for ACS. PMID: 29214779 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Park KH, Jeong MH, Hong YJ, Ahn Y, Kim HK, Koh YY, Kim DI, Kim SW, Kim W, Rha SW, Rhew JY, Park JS, Park HS, Bae JH, Bae JW, Oh SK, Lee SY, Lee SW, Lee JH, Lim SY, Cho JH, Cha KS, Chae JK, Hur SH, Hwang SH, Hwang JY Tags: Yonsei Med J Source Type: research

Mismatch between TOF MR Angiography and CT Angiography of the Middle Cerebral Artery may be a Critical Sign in Cerebrovascular Dynamics.
Abstract PURPOSE: Although time-of-flight (TOF)-magnetic resonance angiography (MRA) can clearly depict intracranial arteries, the arterial flow of middle cerebral artery (MCA) is occasionally not detected. We evaluated this phenomenon with reference to cerebrovascular dynamics. MATERIALS AND METHODS: Seventeen patients with suspected occlusion of MCA or internal carotid artery on TOF-MRA were enrolled. All patients underwent CT angiography (CTA) and quantitative cerebral blood flow (CBF) examination for measurement of resting CBF and cerebrovascular reactivity (CVR). Depending on appearance, patients were ca...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Igase K, Igase M, Matsubara I, Sadamoto K Tags: Yonsei Med J Source Type: research

Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats.
CONCLUSION: Taking these results into account, we concluded that ascorbic acid has both an adipogenic effect as a cofactor of an enzymatic process and a lipolytic effect as an antioxidant. PMID: 29214781 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Kim B, Choi KM, Yim HS, Park HT, Yim JH, Lee MG Tags: Yonsei Med J Source Type: research

Effect of Family History of Diabetes on Hemoglobin A1c Levels among Individuals with and without Diabetes: The Dong-gu Study.
CONCLUSION: FHD was associated not only with high HbA1c levels in people with diabetes, but also with elevated HbA1c levels in people without diabetes. PMID: 29214782 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Lee YH, Shin MH, Nam HS, Park KS, Choi SW, Ryu SY, Kweon SS Tags: Yonsei Med J Source Type: research

Effective Tidal Volume for Normocapnia in Very-Low-Birth-Weight Infants Using High-Frequency Oscillatory Ventilation.
CONCLUSION: In VLBW infants treated with HFOV, VT of 1.75 mL/kg is recommended for maintaining proper ventilation. PMID: 29214783 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Lee SM, Namgung R, Eun HS, Lee SM, Park MS, Park KI Tags: Yonsei Med J Source Type: research

Contrast-Induced Acute Kidney Injury after Coil Embolization for Aneurysmal Subarachnoid Hemorrhage.
CONCLUSION: CI-AKI seems to be an independent predictor of the overall outcomes of aSAH after endovascular treatment. PMID: 29214784 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Lee HG, Kim WK, Yeon JY, Kim JS, Kim KH, Jeon P, Hong SC Tags: Yonsei Med J Source Type: research

Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease.
CONCLUSION: MTX treatment of IVIG-resistant KD resulted in rapid defervescence, improvement of clinical symptoms, and normalization of acute-phase reactants in all patients. Thus, MTX could be a candidate treatment for IVIG-resistant KD. PMID: 29214785 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Jang H, Kim KY, Kim DS Tags: Yonsei Med J Source Type: research

ITPKC and SLC11A1 Gene Polymorphisms and Gene-Gene Interactions in Korean Patients with Kawasaki Disease.
CONCLUSION: This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans. The genetic variants identified in this study affected KD and erythema of BCG injection sites independently and through gene-gene interactions. Also, the effects of the polymorphisms were age-dependent. PMID: 29214786 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Kim KY, Bae YS, Ji W, Shin D, Kim HS, Kim DS Tags: Yonsei Med J Source Type: research

Myocardial Layer-Specific Strain Analysis in Children with Mitochondrial Disease.
CONCLUSION: In children with MD, myocardial circumferential strain may develop early in all three layers, even with normally preserved longitudinal and radial strain. This may be an early diagnostic indicator with which to predict CMP in this patient population. PMID: 29214787 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Eun LY, Lee YM Tags: Yonsei Med J Source Type: research

Asymmetry of Peak Thicknesses between the Superior and Inferior Retinal Nerve Fiber Layers for Early Glaucoma Detection: A Simple Screening Method.
CONCLUSION: The PTR is a simple method with considerable diagnostic ability for early glaucoma detection. It can, therefore, be widely used as a new screening method for early glaucoma. PMID: 29214788 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Bae HW, Lee SY, Kim S, Park CK, Lee K, Kim CY, Seong GJ Tags: Yonsei Med J Source Type: research

microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish.
CONCLUSION: Our work demonstrates that the miR-183 cluster is essential for the regeneration of hair cells following ototoxic injury in zebrafish larvae. Therefore, regulation of the miR-183 cluster can be a novel target for stimulation of hair cell regeneration. PMID: 29214789 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Kim CW, Han JH, Wu L, Choi JY Tags: Yonsei Med J Source Type: research

Variants of Lipolysis-Related Genes in Korean Patients with Very High Triglycerides.
Abstract We investigated the prevalence and characteristics of variants of five lipolysis-related genes in Korean patients with very high triglycerides (TGs). Twenty-six patients with TG levels>885 mg/dL were selected from 13545 Korean subjects. Five candidate genes, LPL, APOC2, GPIHBP1, APOA5, and LMF1, were sequenced by targeted next-generation sequencing. Predictions of functional effects were performed and matched against public databases of variants. Ten rare variants of three genes were found in nine (34.6%) patients (three in LPL, four in APOA5, and three in LMF1). Five were novel and all variants were s...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Lee CJ, Oum CY, Lee Y, Park S, Kang SM, Choi D, Jang Y, Lee JH, Lee SH Tags: Yonsei Med J Source Type: research

A Case of Schnitzler's Syndrome without Monoclonal Gammopathy-Associated Chronic Urticaria Treated with Anakinra.
Abstract Chronic urticaria may often be associated with interleukin (IL)-1-mediated autoinflammatory disease, which should be suspected if systemic inflammation signs are present. Here, we report a case of Schnitzler's syndrome without monoclonal gammopathy treated successfully with the IL-1 receptor antagonist anakinra. A 69-year-old man suffered from a pruritic urticarial rash for 12 years. It became aggravated episodically and was accompanied by high fever, arthralgia, leukocytosis, and an elevated C-reactive protein and erythrocyte sedimentation rate. The episodes each lasted for over one week. Neutrophilic an...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Ahn MJ, Yu JE, Jeong J, Sim DW, Koh YI Tags: Yonsei Med J Source Type: research

Life-Threatening Thrombocytopenia Following Intravenous Contrast Media Infusion.
Abstract Radiocontrast media-induced acute severe thrombocytopenia is a very rare complication and potentially life-threatening. Here, we report the case of a 63-year-old male patient with severe acute thrombocytopenia following first exposure to intravenous non-ionic contrast media without immediate allergic reactions. His platelet count dropped from 107000/μL to 2000/μL after six hours of radiocontrast infusion. After administration of corticosteroid and transfusion of platelet concentrates, the platelet count returned gradually to normal within 5 days. To the best of our knowledge, non-ionic contrast medi...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Park M, Kim M, Park J, Cho J Tags: Yonsei Med J Source Type: research