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An Emerging Role for Circular RNAs in Osteoarthritis.
Abstract Circular RNAs (circRNAs) are currently classed as non-coding RNAs that, unlike the better known canonical linear RNAs, form a covalently closed continuous loop without 5' or 3' polarities. With the development of high throughput sequencing technology, a large number of circRNAs have been discovered in many species. More importantly, growing evidence suggests that circRNAs are abundant, evolutionally conserved, and relatively stable in cells and tissues. Strikingly, recent studies have discovered that circRNAs can serve as microRNA sponges, interact with RNA-binding protein, and regulate gene transcription...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Yu CX, Sun S Tags: Yonsei Med J Source Type: research

Trends in Blood Pressure and Prevalence of Hypertension in Korean Adults Based on the 1998-2014 KNHANES.
Abstract PURPOSE: To investigate trends in blood pressure (BP) and hypertension prevalence in Korea. MATERIALS AND METHODS: Based on the Korean National Health and Nutrition Examination Survey (KNHANES) I (1998), II (2001), III (2005), IV (2007-2009), V (2010-2012), and VI (2013-2014), 56077 participants (23974 men and 32103 women) were included. RESULTS: Mean systolic BP (SBP) and diastolic BP (DBP) decreased in both sexes (male SBP: 128.1 to 120.2 mm Hg, male DBP: 82.0 to 78.5 mm Hg; female SBP: 125.7 to 116.0 mm Hg and female DBP: 77.4 to 73.2 mm Hg from the KNHANES I-VI). The age-standardized prevale...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Kim TJ, Lee JW, Kang HT, Cho MC, Lim HJ, Kim JY, Bae JW, Lee YJ, Lee SH, Linton JA, Kim Y Tags: Yonsei Med J Source Type: research

Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation.
CONCLUSION: Increased L-arginine levels following limonin-dependent arginase inhibition prohibited NADPH oxidase activation in a PKCβII-dependent manner, and blocked nLDL-stimulated VSMC proliferation. PMID: 29611398 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S Tags: Yonsei Med J Source Type: research

Effect of Central Line Bundle Compliance on Central Line-Associated Bloodstream Infections.
CONCLUSION: This study provides direct evidence that completing all CL bundle components perfectly is essential for preventing CLABSIs. Customized education should be provided, according to specific weaknesses of bundle performance. PMID: 29611399 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Lee KH, Cho NH, Jeong SJ, Kim MN, Han SH, Song YG Tags: Yonsei Med J Source Type: research

Real World Experience of Telbivudine Versus Entecavir in Patients with Chronic Hepatitis B, Including Long-Term Outcomes after Treatment Modification.
CONCLUSION: During the 3-year study, there were no significant differences in the CVR between the ETV and LdT groups if appropriate rescue therapy was considered. PMID: 29611400 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Choi JW, Kim SH, Seo JH, Cho YS, Won SY, Park BK, Jeon HH, Lee YK, Lee CK Tags: Yonsei Med J Source Type: research

Low-Dose Unenhanced Computed Tomography with Iterative Reconstruction for Diagnosis of Ureter Stones.
Abstract PURPOSE: To study the clinical application of low-dose unenhanced computed tomography with iterative reconstruction technique (LDCT-IR) on renal colic in the emergency department. MATERIALS AND METHODS: We conducted a prospective, single-blinded, randomized, and non-inferiority study. From March 2014 to August 2015, 112 patients with renal colic were included, and were randomized to either LDCT-IR (n=46) or standard-dose unenhanced CT (SDCT) (n=66) groups. The accuracy of urolithiasis diagnosis was the primary endpoint of this study. Radiation dose, size and location of the stone, hydronephrosis, oth...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Chi BH, Chang IH, Lee DH, Park SB, Kim KD, Moon YT, Huh TK Tags: Yonsei Med J Source Type: research

Delta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse in ANCA-Associated Vasculitis.
CONCLUSION: DNI could reflect BVAS at diagnosis and furthermore, DNI ≥0.65% could not only identify severe AAV at diagnosis, but also predict relapse during the follow-up in patients with GPA and MPA. PMID: 29611402 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Yoo J, Ahn SS, Jung SM, Song JJ, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods.
CONCLUSION: Our results suggest that ICV and IV injections of pMSCs facilitate the recovery of cholinergic neuronal populations and cognitive behavior. This recovery likely occurs through paracrine effects that resemble microglia function rather than direct differentiation of injected pMSCs into cholinergic neurons. PMID: 29611403 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW Tags: Yonsei Med J Source Type: research

MiR-212 Attenuates MPP ⁺-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells.
CONCLUSION: miR-212 might attenuate MPP⁺-induced neuronal damage by regulating KLF4/Notch signaling pathway in SH-SY5Y cells, a promising target for PD therapy. PMID: 29611404 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Song Y, Liu Y, Chen X Tags: Yonsei Med J Source Type: research

Vocalization of Emotional and Social Expressions in Korean-Speaking Toddlers with Autism Spectrum Disorder and Those with Developmental Delay.
CONCLUSION: Results from this study indicate the importance of assessing early vocalizations in toddlers with ASD, suggesting that some common symptoms of ASD, such as lack of typical, emotional, and social functions in early vocalizations, could be used to develop screening and intervention programs related to ASD. PMID: 29611405 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Lee KS, Shin YJ, Yoo HJ, Lee GJ, Ryu J, Son O, Cho SW Tags: Yonsei Med J Source Type: research

Phenotypic Analysis of Korean Patients with Abnormal Chromosomal Microarray in Patients with Unexplained Developmental Delay/Intellectual Disability.
CONCLUSION: Dysmorphism can be a phenotypic clue to pathogenic CNVs. Furthermore, pathogenic CNV might be more frequently found if patients have two or more clinical features in addition to DD/ID. PMID: 29611406 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Kim HJ, Park CI, Lim JW, Lee GM, Cho E, Kim HJ Tags: Yonsei Med J Source Type: research

Radiographic and Clinical Outcomes of Robot-Assisted Posterior Pedicle Screw Fixation: Two-Year Results from a Randomized Controlled Trial.
Abstract PURPOSE: We prospectively assessed the early radiographic and clinical outcomes (minimum follow-up of 2 years) of robot-assisted pedicle screw fixation (Robot-PSF) and conventional freehand pedicle screw fixation (Conv-PSF). MATERIALS AND METHODS: Patients were randomly assigned to Robot-PSF (37 patients) or Conv-PSF (41 patients) for posterior interbody fusion surgery. The Robot-PSF group underwent minimally invasive pedicle screw fixation using a pre-planned robot-guided screw trajectory. The Conv-PSF underwent screw fixation using the freehand technique. Radiographic adjacent segment degeneration ...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Park SM, Kim HJ, Lee SY, Chang BS, Lee CK, Yeom JS Tags: Yonsei Med J Source Type: research

The Effect of Mental Rotation on Surgical Pathological Diagnosis.
CONCLUSION: Mental rotation did not influence the pathologists' diagnosis in practice. Interestingly, outliers were more frequent in rotated image sets, suggesting that the mental rotation process may influence the pathological diagnoses of a few individual pathologists. PMID: 29611408 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Park H, Kim HS, Cha YJ, Choi J, Minn Y, Kim KS, Kim SH Tags: Yonsei Med J Source Type: research

Safety of Tocilizumab in Rheumatoid Arthritis Patients with Resolved Hepatitis B Virus Infection: Data from Real-World Experience.
Abstract To investigate whether the use of IL-6 receptor antagonist (tocilizumab) might be associated with hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients, particularly in those with resolved HBV infection [HBV surface antigen (HBsAg) negative and antibody to HBV core antigen (anti-HBc) positive, serologically]. HBsAg, anti-HBc, antibody to HBsAg (anti-HBs), and HBV DNA titers were measured in RA patients who had continuously received tocilizumab for more than 3 months. Patients were divided into two groups according to the presence of anti-HBc. Clinical and laboratory data, in addition ...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Ahn SS, Jung SM, Song JJ, Park YB, Park JY, Lee SW Tags: Yonsei Med J Source Type: research

Total Transcanal Endoscopic Facial Nerve Decompression for Traumatic Facial Nerve Palsy.
Abstract A few approaches can be used to decompress traumatic facial nerve paralysis including the middle cranial fossa approach or transmastoid approach depending on the site of injury. In some specific situation of treating traumatic facial nerve palsy whose injured site was confined from the geniculate ganglion to the second genu, transcanal endoscopic approach for facial nerve decompression can be used. We performed two cases of total endoscopic transcanal facial nerve decompression in patients with traumatic facial nerve palsy. After a six month follow-up, both patients showed improvement in facial function b...
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Authors: Kahinga AA, Han JH, Moon IS Tags: Yonsei Med J Source Type: research

Erratum to "Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis" by Park BH, et al. (Yonsei Med J 2017;58:756-762.).
Erratum to "Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis" by Park BH, et al. (Yonsei Med J 2017;58:756-762.). Yonsei Med J. 2018 May;59(3):461 Authors: Abstract This corrects the article on p. 756 in vol. 58, PMID: 28540988. PMID: 29611411 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 4, 2018 Category: Universities & Medical Training Tags: Yonsei Med J Source Type: research

Dr. Myung-Sun Kim (1897-1982): An Eternal Teacher of Yonsei University.
PMID: 29436182 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Ahn DS Tags: Yonsei Med J Source Type: research

Dr. Charles Inglis McLaren (1882-1957): A Psychiatrist who Treated the Korean Soul.
PMID: 29436183 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Yeo IS Tags: Yonsei Med J Source Type: research

Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases.
Abstract Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect against them is to develop vaccines in advance. Systems biology approaches provide an integrative way to understand the complex immune response to pathogens. They can lead to a greater understanding of EID pathogenesis and facilitate the evaluation of newly developed vaccine-induced immunity in a timely manner. In recent years, advances in high throughput technologies have enabled researchers to successfully apply syst...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Oh SJ, Choi YK, Shin OS Tags: Yonsei Med J Source Type: research

Emotional Labor and Burnout: A Review of the Literature.
Abstract This literature review was conducted to investigate the association between emotional labor and burnout and to explore the role of personality in this relationship. The results of this review indicate that emotional labor is a job stressor that leads to burnout. Further examination of personality traits, such as self-efficacy and type A behavior pattern, is needed to understand the relationships between emotional labor and health outcomes, such as burnout, psychological distress, and depression. The results also emphasized the importance of stress management programs to reduce the adverse outcomes of emot...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jeung DY, Kim C, Chang SJ Tags: Yonsei Med J Source Type: research

Hypofractionated Re-irradiation after Maximal Surgical Resection for Recurrent Glioblastoma: Therapeutic Adequacy and Its Prognosticators of Survival.
CONCLUSION: HFReRT after maximal surgery prolonged survival in selected patients with recurrent GBM, especially those with small-sized recurrences in non-eloquent areas and good performance. PMID: 29436186 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Lee J, Ahn SS, Chang JH, Suh CO Tags: Yonsei Med J Source Type: research

Efficacy of Pemetrexed-based Chemotherapy in Comparison to Non-Pemetrexed-based Chemotherapy in Advanced, ALK+ Non-Small Cell Lung Cancer.
Abstract PURPOSE: Previous retrospective studies suggest that anaplastic lymphoma kinase (ALK) mutation-positive (ALK+) non-small cell lung cancer (NSCLC) patients are sensitive to pemetrexed. To determine its efficacy, we retrospectively evaluated clinical outcomes of pemetrexed-based chemotherapy in patients with ALK+ NSCLC. MATERIALS AND METHODS: We identified 126 patients with advanced, ALK+ NSCLC who received first-line cytotoxic chemotherapy. We compared response, progression-free survival (PFS), and overall survival (OS) rates according to chemotherapy regimens. Furthermore, we evaluated intracranial t...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jo J, Kim SH, Kim YJ, Lee J, Kim M, Keam B, Kim TM, Kim DW, Heo DS, Chung JH, Jeon YK, Lee JS Tags: Yonsei Med J Source Type: research

Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis.
CONCLUSION: We demonstrated that PNA clamping has a higher sensitivity than DS for detecting oncogenic alterations in NSCLC. Our findings suggest that PNA clamping is a more useful method for clinical practice. PMID: 29436188 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Song JU, Lee J Tags: Yonsei Med J Source Type: research

Prostate-Specific Antigen Kinetics Following 5 α-Reductase Inhibitor Treatment May Be a Useful Indicator for Repeat Prostate Biopsy.
CONCLUSION: The effects of 5ARIs on prostate cancer detection and chemoprevention remain uncertain. However, more than two increases in PSA level after 6 months of 5ARI treatment may indicate the presence of prostate cancer. PMID: 29436189 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Heo JE, Koo KC, Hong SJ, Park SU, Chung BH, Lee KS Tags: Yonsei Med J Source Type: research

Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression.
CONCLUSION: TUG1 facilitated proliferation and suppressed apoptosis by regulating the miR-132-3p/SOX4 axis in human OS cell lines and primary OS cells. This finding provides a potential target for OS therapy. PMID: 29436190 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Li G, Liu K, Du X Tags: Yonsei Med J Source Type: research

CHA ₂DS₂-VASc Score in the Prediction of Ischemic Stroke in Patients after Radiofrequency Catheter Ablation of Typical Atrial Flutter.
This study investigates whether CHA₂DS₂-VASc score is useful for predicting ischemic stroke after successful ablation of typical AFL. MATERIALS AND METHODS: A total of 293 patients (236 men, mean age 56.1±13.5 years) who underwent successful radiofrequency catheter ablation for typical AFL were included in this study. The clinical end point was occurrence of ischemic stroke during follow-up after AFL ablation. RESULTS: During the follow-up period (60.8±45.9 months), ischemic stroke occurred in 18 (6%) patients at a median of 34 months (interquartile range, 13-65 months). CHA₂DS₂-VASc score [...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jin MN, Song C, Kim TH, Uhm JS, Pak HN, Lee MH, Joung B Tags: Yonsei Med J Source Type: research

Effects of Physician Volume on Readmission and Mortality in Elderly Patients with Heart Failure: Nationwide Cohort Study.
CONCLUSION: Physician volume is related to lower readmission and mortality for heart failure. Of interest, 30-day readmission and 1-year mortality were significantly associated with the combined effects of physician and institution bed volume. PMID: 29436192 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Lee JE, Park EC, Jang SY, Lee SA, Choy YS, Kim TH Tags: Yonsei Med J Source Type: research

Coronary Flow Reserve in Non-Infarcted Myocardium Predicts Long-Term Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention.
Abstract PURPOSE: Coronary flow reserve (CFR) is recognized as an indicator of myocardial perfusion. The aim of this study was to assess the relationship between CFR in the non-infarcted myocardium and the incidence of major adverse cardiac events (MACEs). MATERIALS AND METHODS: 100 consecutive patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) were enrolled in the present study, and divided into MACE and non-MACE groups according to the incidence of 12-month MACEs. Left ventricular function and CFR were analyzed using two-dimensional echocardiography and myoca...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Cheng R, Zhu X, Li Y, Bai X, Xue L, Wei L Tags: Yonsei Med J Source Type: research

Comparison of Rhythm and Rate Control Strategies for Stroke Occurrence in a Prospective Cohort of Atrial Fibrillation Patients.
Abstract PURPOSE: Comparisons of rhythm and rate control strategies for stroke prevention in patients with atrial fibrillation (AF) are still inconclusive. We compared differences in clinical outcomes between the rhythm and rate control strategies. MATERIALS AND METHODS: The COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry prospectively enrolled 6000 patients who were treated for AF using real-world guideline adherence at multiple referral centers. In total, 2508 (41.8%) patients were clinically followed up for over six months. Of these, 1134 ...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Choi YJ, Kang KW, Kim TH, Cha MJ, Lee JM, Park J, Park JK, Shim J, Uhm JS, Kim J, Park HW, Choi EK, Kim JB, Kim C, Lee YS, Joung B Tags: Yonsei Med J Source Type: research

Impact of Ambulatory Blood Pressure on Early Cardiac and Renal Dysfunction in Hypertensive Patients without Clinically Apparent Target Organ Damage.
Abstract PURPOSE: Impaired left ventricular (LV) global longitudinal strain (GLS) and the presence of microalbuminuria indicate early cardiac and renal dysfunction. We aimed to determine the relationships among 24-h ambulatory blood pressure (BP) variables, LV GLS, and urine albumin creatinine ratio (UACR) in hypertensive patients. MATERIALS AND METHODS: A total of 130 hypertensive patients (mean age 53 years; 59 men) underwent 24-h ambulatory BP monitoring, measurements of peripheral and central BPs, and transthoracic echocardiography. Patients with apparent LV systolic dysfunction (LV ejection fraction
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim D, Shim CY, Hong GR, Park S, Cho IJ, Chang HJ, Ha JW, Chung N Tags: Yonsei Med J Source Type: research

Predictors of Long-Term Outcomes of Percutaneous Mitral Valvuloplasty in Patients with Rheumatic Mitral Stenosis.
Abstract PURPOSE: We determined factors associated with long-term outcomes of patients who underwent successful percutaneous mitral balloon valvuloplasty (PMV). MATERIALS AND METHODS: Between August 1980 and May 2013, 1187 patients underwent PMV at Severance Hospital, Seoul, Korea. A total of 742 patients who underwent regular clinic visits for more than 10 years were retrospectively analyzed. The endpoints consisted of repeated PMV, mitral valve (MV) surgery, and cardiovascular-related death. RESULTS: The optimal result, defined as a post-PMV mitral valve area (MVA)>1.5 cm² and mitral regurgitat...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim D, Chung H, Nam JH, Park DH, Shim CY, Kim JS, Chang HJ, Hong GR, Ha JW Tags: Yonsei Med J Source Type: research

The Role of Serotonin in Ventricular Repolarization in Pregnant Mice.
CONCLUSION: Serotonin increases repolarizing currents by augmenting Kv currents. Elevated serotonin levels during pregnancy counterbalance pregnancy-related QT prolongation by facilitating Htr3-mediated Kv currents. PMID: 29436197 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B Tags: Yonsei Med J Source Type: research

Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome: KoGES-ARIRANG Study.
Abstract PURPOSE: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population-based prospective study. MATERIALS AND METHODS: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population-based cohort study who were examined from 2005-2008 (baseline) and from 2...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Choi JR, Kim JY, Park IH, Huh JH, Kim KW, Cha SK, Park KS, Sohn JH, Park JT, Koh SB Tags: Yonsei Med J Source Type: research

Red Blood Cell Distribution Width Can Predict Vasculitis Activity and Poor Prognosis in Granulomatosis with Polyangiitis.
CONCLUSION: RDW predicts vasculitis activity in GPA, and RDW ≥15.4% at diagnosis may increase the risk of severe GPA at diagnosis and predict refractory diseases during follow-up. PMID: 29436199 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim HJ, Yoo J, Jung SM, Song JJ, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

Digital Videoscopic Retrograde Intrarenal Surgeries for Renal Stones: Time-to-Maximal Stone Length Ratio Analysis.
CONCLUSION: Low MSDs and the last 50 cases were significant predictors of stone-free rate in videoscopic RIRS. PMID: 29436200 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jeong JY, Kim JC, Kang DH, Lee JY Tags: Yonsei Med J Source Type: research

Infarct Core Expansion on Computed Tomography before and after Intravenous Thrombolysis.
Abstract PURPOSE: Infarct core can expand rapidly in acute stroke patients receiving intravenous tissue plasminogen activator (IV t-PA). We investigated changes in the extent of infarct core during IV t-PA treatment, and explored the associative factors of this infarct core expansion in patients with proximal artery occlusion. MATERIALS AND METHODS: We included patients who were considered for sequential intra-arterial therapy (IAT) due to occlusion of intracranial proximal artery after IV t-PA. Patients who had a baseline Alberta Stroke Program Early Computed Tomography (CT) Score (ASPECTS) ≥6 and who und...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Song D, Yoo J, Baek JH, Kim J, Lee HS, Kim YD, Nam HS, Heo JH Tags: Yonsei Med J Source Type: research

Prevalence of Frailty in Patients with Osteoporotic Vertebral Compression Fracture and Its Association with Numbers of Fractures.
Abstract PURPOSE: To assess the association between frailty and osteoporotic vertebral compression fracture (OVCF) and to evaluate the relationship between numbers of OVCFs and frailty. MATERIALS AND METHODS: We enrolled 760 subjects, including 59 patients (with OVCF) and 701 controls (without OVCF). Successful matching provided 56 patient-control pairs. We analyzed principal clinical and demographic information, which included sex, age, height, weight, body mass index (BMI), variable frailty phenotypes, and Oswestry Disability Index (ODI) and EuroQol 5-dimension questionnaire (EQ-5D) scores. The association ...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kim HJ, Park S, Park SH, Park J, Chang BS, Lee CK, Yeom JS Tags: Yonsei Med J Source Type: research

Development of a Gustatory Function Test for Clinical Application in Korean Subjects.
CONCLUSION: This gustatory function test was easy to perform, affordable, and time-saving, with the capacity to self-produce and obtain reliable data. Gustatory function was more sensitive in young people, women, and non-smokers. PMID: 29436203 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Hwang CS, Kim JW, Al Sharhan SS, Kim JW, Cho HJ, Yoon JH, Kim CH Tags: Yonsei Med J Source Type: research

Improvement in Ovarian Tissue Quality with Supplementation of Antifreeze Protein during Warming of Vitrified Mouse Ovarian Tissue.
This study sought to compare AFP treatment protocols: a conventional protocol with AFP treatment during vitrification and first-step warming and a new protocol with AFP treatment during the first-step warming only. According to the protocols, 10 mg/mL of LeIBP (a type of AFP) was used. Five-week-old B6D2F1 mouse ovaries were randomly divided into a vitrified-warmed control and two experimental groups, one treated with the conventional AFP treatment protocol (LeIBP-all) and the other with the new AFP treatment protocol (LeIBP-w). For evaluation, ratios of ovarian follicle integrity, apoptosis, and DNA double-strand (DDS) da...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Kong HS, Kim EJ, Youm HW, Kim SK, Lee JR, Suh CS, Kim SH Tags: Yonsei Med J Source Type: research

FAT1 Gene Alteration in Facioscapulohumeral Muscular Dystrophy Type 1.
We describe a 59-year-old woman with both contracted D4Z4 repeat units and a FAT1 mutation. Shoulder girdle muscle weakness developed at the age of 56 years, and was followed by proximal leg weakness. When we examined her at 59 years of age, she displayed asymmetric and predominant weakness of facial and proximal muscles. Muscle biopsy showed increased variation in fiber size and multifocal degenerating fibers with lymphocytic infiltration. Southern blot analysis revealed 8 D4Z4 repeat units, and targeted sequencing of modifier genes demonstrated the c.10331 A>G variant in the FAT1 gene. This FAT1 variant has previously...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Park HJ, Lee W, Kim SH, Lee JH, Shin HY, Kim SM, Park KD, Lee JH, Choi YC Tags: Yonsei Med J Source Type: research

Olmsted Syndrome Caused by a Heterozygous p.Gly568Val Missense Mutation in TRPV3 Gene.
We report a case of OS in a 3-year-old Korean girl and its underlying gene mutation. The patient presented with a disabling, bilateral palmoplantar keratoderma with onychodystrophy. She also exhibited pruritic eczematous skin lesions around her eyes, ears and gluteal fold. Genetic analysis identified a heterozygous p.Gly568Val missense mutation in the exon 13 of TRPV3. To our knowledge, this is the first case of OS in the Korean population showing a missense mutation p.Gly573Ser. PMID: 29436206 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Choi JY, Kim SE, Lee SE, Kim SC Tags: Yonsei Med J Source Type: research

Alternative Surgical Methods in Patients with Recurrent Palmar Hyperhidrosis and Compensatory Hyperhidrosis.
Abstract Recurrent hyperhidrosis after thoracic sympathectomy is an uncomfortable condition, and compensatory hyperhidrosis (CH) is one of the most troublesome side effects. Here, we describe two patients with recurrent palmar hyperhidrosis (PH) and CH over the whole body simultaneously. They were treated with bilateral T4 sympathetic clipping and reconstruction of the sympathetic nerve from a T5 to T8 sympathetic nerve graft, which was transferred to the resected T3 sympathetic bed site. They reported improvements in sweating and were fully satisfied with the results. Our method can be considered as an alternativ...
Source: Yonsei Medical Journal - February 13, 2018 Category: Universities & Medical Training Authors: Jung HS, Lee DY, Park JS Tags: Yonsei Med J Source Type: research

Preeminent Medical Missionary in the 20th Century: Oliver R. Avison.
PMID: 29214769 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Choi JK Tags: Yonsei Med J Source Type: research

Disruption of the Gut Ecosystem by Antibiotics.
Abstract The intestinal microbiota is a complex ecosystem consisting of various microorganisms that expands human genetic repertoire and therefore affects human health and disease. The metabolic processes and signal transduction pathways of the host and intestinal microorganisms are intimately linked, and abnormal progression of each process leads to changes in the intestinal environment. Alterations in microbial communities lead to changes in functional structures based on the metabolites produced in the gut, and these environmental changes result in various bacterial infections and chronic enteric inflammatory d...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Yoon MY, Yoon SS Tags: Yonsei Med J Source Type: research

Detection of Rare Mutations in EGFR-ARMS-PCR-Negative Lung Adenocarcinoma by Sanger Sequencing.
This study aimed to identify potential epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer that went undetected by amplification refractory mutation system-Scorpion real-time PCR (ARMS-PCR). MATERIALS AND METHODS: A total of 200 specimens were obtained from the First Affiliated Hospital of Guangzhou Medical University from August 2014 to August 2015. In total, 100 ARMS-negative and 100 ARMS-positive specimens were evaluated for EGFR gene mutations by Sanger sequencing. The methodology and sensitivity of each method and the outcomes of EGFR-tyrosine kinase inhibitor (TKI) therapy were a...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Liang C, Wu Z, Gan X, Liu Y, You Y, Liu C, Zhou C, Liang Y, Mo H, Chen AM, Zhang J Tags: Yonsei Med J Source Type: research

Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell.
This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible mechanism. MATERIALS AND METHODS: The pancreatic cancer cell line SW1990 was cultured and treated with PAB dose- and time-dependent manners. Cell proliferation and invasion ability were measured by MTT assay and Matrigel/Transwell test, respectively. Semi-quantitative real-time polymerase chain reaction and Western blotting were conducted to detect the expression of EMT markers and the key molecules. Finally, nude mic...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Li X, Zhao X, Song W, Tian Z, Yang L, Niu Q, Zhang Q, Xie M, Zhou B, Xu Y, Wu J, Zhang C Tags: Yonsei Med J Source Type: research

Protective Effects of Female Reproductive Factors on Lauren Intestinal-Type Gastric Adenocarcinoma.
CONCLUSION: These findings support that female sex hormones might be protective against intestinal-type gastric cancer. PMID: 29214773 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Kim SM, Min BH, Lee J, An JY, Lee JH, Sohn TS, Bae JM, Kim JJ, Kang WK, Kim S, Choi MG Tags: Yonsei Med J Source Type: research

Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer.
Abstract PURPOSE: To investigate the association of cancer stem-cell markers [octamer-binding transcription factor 4 (OCT4), sex determining region Y-box 2 (SOX2), and Nanog homebox (NANOG)] expression with clinicopathological properties and overall survival (OS) in operative rectal cancer (RC) patients receiving adjuvant therapy. MATERIALS AND METHODS: 153 patients with primary RC receiving surgery were enrolled. Tumor tissue and paired adjacent normal tissue sample were collected, and OCT4, SOX2, and NANOG expressions were assessed by immunofluorescent staining. The median follow-up duration was 5.2 years, ...
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: You L, Guo X, Huang Y Tags: Yonsei Med J Source Type: research

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.
CONCLUSION: TRIM56 may act as a tumor suppressor in MM through activation of TLR3/TRIF signaling pathway, contributing to a better understanding of the molecular mechanism of TRIM56 involvement in MM pathogenesis and providing a promising therapy strategy for patients with MM. PMID: 29214775 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M Tags: Yonsei Med J Source Type: research

14-3-3 ζ Overexpression is Associated with Poor Prognosis in Ovarian Cancer.
CONCLUSION: 14-3-3ζoverexpression might be a potential prognostic biomarker for ovarian cancer, and the inhibition of 14-3-3ζcould be a therapeutic option that enhances the antitumor activity of cisplatin. PMID: 29214776 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 8, 2017 Category: Universities & Medical Training Authors: Kim HJ, Sung SH, Kim CY, Bae MK, Cho MS, Kim YH, Kim SC, Ju W Tags: Yonsei Med J Source Type: research