Current State and Strategy for Establishing a Digitally Innovative Hospital: Memorial Review Article for Opening of Yongin Severance Hospital.
Abstract The emergence of new technologies, especially digital transformation, influences the entire society, including the medical aspects. Therefore, the concept of digital hospital has been emerging. Here we present the Yongin Severance Hospital, which has developed various novel solutions to serve as foundations for the establishment of a digitally innovative hospital. Further strategies have also been provided to implement consistent and long-term planning. PMID: 32734727 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Kim SJ, Roh JW, Kim S, Park JY, Choi D Tags: Yonsei Med J Source Type: research

Optimal PSA Threshold for Androgen-Deprivation Therapy in Patients with Prostate Cancer following Radical Prostatectomy and Adjuvant Radiation Therapy.
Abstract PURPOSE: The benefits of early administration of androgen-deprivation therapy (ADT) in patients with prostate-specific antigen (PSA)-only recurrent prostate cancer (PCa) following radical prostatectomy (RP) are controversial. We investigated the impact of early versus delayed ADT on survival outcomes in patients with non-metastatic, localized or locally advanced PCa who received radiation therapy (RT) following RP and later developed distant metastasis. MATERIALS AND METHODS: A retrospective analysis was performed on 69 patients with non-metastatic, localized or locally advanced PCa who received RT f...
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Ahn HK, Lee KS, Kim D, Rha KH, Hong SJ, Chung BH, Koo KC Tags: Yonsei Med J Source Type: research

Overexpression of miR-146b-5p Ameliorates Neonatal Hypoxic Ischemic Encephalopathy by Inhibiting IRAK1/TRAF6/TAK1/NF- αB Signaling.
CONCLUSION: This study demonstrated that miR-146b-5p overexpression alleviates HIE-induced neuron injury by inhibiting the IRAK1/TRAF6/TAK1/NF-κB pathway. PMID: 32734729 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Yang G, Zhao Y Tags: Yonsei Med J Source Type: research

Clinical Usefulness of Fungal Culture of EBUS-TBNA Needle Rinse Fluid and Core Tissue.
CONCLUSION: Routine fungal culture of EBUS-TBNA needle rinse fluid is not useful due to the low incidence of fungal infection and high rate of contamination. However, fungal culture of EBUS-TBNA core tissue and needle rinse fluid should be considered in patients with clinically suspected fungal infection. PMID: 32734730 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Ko RE, Jeong BH, Huh HJ, Lee NY, Yoo H, Jhun BW, Han J, Lee K, Kim H, Kwon OJ, Um SW Tags: Yonsei Med J Source Type: research

Cell Division Cycle 2 Protects Neonatal Rats Against Hyperoxia-Induced Bronchopulmonary Dysplasia.
CONCLUSION: Overexpression of CDC2 promoted the viability and inhibited the apoptosis and inflammation of hyperoxia-induced cells, and alleviated the histopathologic changes of lung tissues in neonatal rats with hyperoxia-induced BPD. PMID: 32734731 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Li Z, Chen Y, Li W, Yan F Tags: Yonsei Med J Source Type: research

Effects of Air Purifiers on Patients with Allergic Rhinitis: a Multicenter, Randomized, Double-Blind, and Placebo-Controlled Study.
CONCLUSION: The use of air purifiers with HEPA filters significantly reduced medication requirements for patients with HDM-induced AR and significantly lowered indoor PM2.5 concentrations, regardless of room placement. Active intervention to reduce household air pollutants may help improve allergic airway disease (clinicaltrials.gov NCT03313453). PMID: 32734732 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Park KH, Sim DW, Lee SC, Moon S, Choe E, Shin H, Kim SR, Lee JH, Park HH, Huh D, Park JW Tags: Yonsei Med J Source Type: research

Identification of Fungal Species and Detection of Azole-Resistance Mutations in the Aspergillus fumigatus cyp51A Gene at a South Korean Hospital.
CONCLUSION: Panfungal PCR assay with FFPE samples may provide additional information of use to fungal species identification. No azole-resistance mediating mutations in the A. fumigatus cyp51A gene were identified among FFPE samples during study period. PMID: 32734733 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Jung IY, Lee YJ, Shim HS, Cho YS, Sohn YJ, Hyun JH, Baek YJ, Kim MH, Kim JH, Ahn JY, Jeong SJ, Ku NS, Park YS, Yeom JS, Kim YK, Kim HY, Choi JY Tags: Yonsei Med J Source Type: research

Survival Trend of HIV/AIDS Patients Starting Antiretroviral Therapy in South Korea between 2001 and 2015.
Abstract PURPOSE: In the recent antiretroviral therapy (ART) era, a large proportion of Korean patients with human immunodeficiency virus (HIV) infection were shown to have low CD4 cell counts at diagnosis and during ART initiation. We investigated the survival trends in patients living with HIV/acquired immunodeficiency syndrome (AIDS) in Korea who started ART in the 2000s, and evaluated the risk factors for mortality to elucidate the association between survival and low CD4 cell counts at ART initiation. MATERIALS AND METHODS: Patients with HIV infection who were aged>18 years and had started ART between...
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Kim YC, Ahn JY, Kim HY, Song JY, Park DW, Kim MJ, Choi HJ, Kim SW, Kee MK, Han MG, Yoo M, Kim SM, Choi Y, Choi BY, Kim SI, Choi JY Tags: Yonsei Med J Source Type: research

Rituximab Biosimilar Prevents Poor Outcomes of Microscopic Polyangiitis and Granulomatosis with Polyangiitis as Effectively as Rituximab Originator.
CONCLUSION: Truxima® prevents poor outcomes of MPA and GPA as effectively as does Mabthera®. PMID: 32734735 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Kwon HC, Kim MK, Song JJ, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Is Inversely Correlated with the Activity of ANCA-Associated Vasculitis.
Abstract Lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1) binds to oxidized LDL, which is associated with inflammation in various vascular disorders. Here, we aimed to investigate the potential of soluble LOX1 (sLOX1) as an indicator of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) activity. Serum levels of sLOX1 in frozen samples from patients with AAV enrolled in a prospective observational cohort study at the Severance Hospital were measured using enzyme-linked immunosorbent assay. Clinical and laboratory data were collected on the date when the blood sampling was performed...
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Yoon T, Ahn SS, Song JJ, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

Network Analysis of Language Disorganization in Patients with Schizophrenia.
Abstract Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been examined in patients with schizophrenia. Thus, our preliminary study aimed to evaluate the network structure using the Clinical Language Disorder Rating Scale (CLANG) in 167 inpatients with schizophrenia. All 17 of the CLANG items were considered to be ordered categorical variables ranging from 0 to 3. Our results ...
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Park SC, Kim K, Jang OJ, Yoon HJ, Jang SH, Kim SW, Lee BJ, Park JH, Lee KU, Choi J Tags: Yonsei Med J Source Type: research

An Autopsy-Proven Case of Limbic-Predominant Age-Related TDP-43 Encephalopathy.
Abstract Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently established neurodegenerative disease entity. LATE neuropathological change (LATE-NC) is characterized by a TDP-43 proteinopathy that mainly involves the amygdala and medial temporal structures, with or without hippocampal sclerosis. LATE-NC is typically observed in individuals aged 80 years or older and manifests clinically as amnestic memory decline. Herein, we report a case of LATE diagnosed by brain autopsy in an 82-year-old male who had an 11-year history of memory impairment. Pathological examination revealed high Alzheimer di...
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Cho SH, Choi SM, Kim BC, Song WY, Kim HS, Lee KH Tags: Yonsei Med J Source Type: research

Delayed Remote Intracerebral Hemorrhage after Wingspan Stenting for Internal Carotid Artery Stenosis Following the On-Label Usage Guidelines.
Abstract Remote intracerebral hemorrhage (ICH) is defined as an ICH that occurs at a distant site from the treated lesion and is a considerable post-neurointerventional complication. Because such a life-threatening complication should not be neglected, we report our experience with delayed remote ICH in a patient with symptomatic intracranial atherosclerotic stenosis (ICAS) treated by Wingspan stenting following on-label usage guidelines. A middle-aged person suffered a lobar-type subcortical hemorrhage on the left temporal lobe 22 days after Wingspan stenting in the left internal carotid artery. The present case ...
Source: Yonsei Medical Journal - August 1, 2020 Category: Universities & Medical Training Authors: Kim JH, Chung J Tags: Yonsei Med J Source Type: research

Waun Ki Hong, MD, D.M.Sc (Hon) (1942-2019): A Mentor Who Left Behind a Legacy for Generations to Come.
PMID: 32608198 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Chung HC Tags: Yonsei Med J Source Type: research

KIT and Melanoma: Biological Insights and Clinical Implications.
Abstract Melanoma, originating from epidermal melanocytes, is a heterogeneous disease that has the highest mortality rate among all types of skin cancers. Numerous studies have revealed the cause of this cancer as related to various somatic driver mutations, including alterations in KIT-a proto-oncogene encoding for a transmembrane receptor tyrosine kinase. Although accounting for only 3% of all melanomas, mutations in c-KIT are mostly derived from acral, mucosal, and chronically sun-damaged melanomas. As an important factor for cell differentiation, proliferation, and survival, inhibition of c-KIT has been exploi...
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Pham DDM, Guhan S, Tsao H Tags: Yonsei Med J Source Type: research

mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer.
CONCLUSION: Specific combinations of CSC markers and β-catenin/mTOR signaling could be a significant predictor of poor survival in stage II CRC. PMID: 32608200 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Chang JY, Kim JH, Kang J, Park Y, Park SJ, Cheon JH, Kim WH, Kim H, Park JJ, Kim TI Tags: Yonsei Med J Source Type: research

Changes in Abdominal Obesity Affect the Risk of Metachronous Advanced Colorectal Neoplasia Development after Polypectomy.
CONCLUSION: Changes in obesity affected the metachronous CRN risk. In particular, changes in abdominal obesity affected the metachronous ACRN risk. PMID: 32608201 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Jung YS, Kim NH, Park JH, Park DI, Sohn CI Tags: Yonsei Med J Source Type: research

Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells.
CONCLUSION: HSP90 inhibitor monotherapy and in combination with the PI3K/mTOR survival pathway inhibitor NVP-BEZ235 shows a synergistic antitumor effect in cisplatin-resistant bladder cancers, eliciting cell cycle arrest at the G1 phase and induction of caspase-dependent apoptotic pathway. PMID: 32608202 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Kim HJ, Gong MK, Yoon CY, Kang J, Yun M, Cho NH, Rha SY, Choi YD Tags: Yonsei Med J Source Type: research

Determinants and Clinical Outcomes of Extended Dual Antiplatelet Therapy over 3 Years after Drug-Eluting Stent Implantation: A Retrospective Analysis.
Abstract PURPOSE: Although current guidelines recommend the administration of dual antiplatelet therapy (DAPT) for up to 12 months after the implantation of a drug-eluting stent (DES), extended DAPT is frequently used in real-world practice. MATERIALS AND METHODS: From the Korean Multicenter Angioplasty Team registry, we identified a total of 1414 patients who used DAPT for>3 years after DES implantation (extended-DAPT group) and conducted a landmark analysis at 36 months after the index procedure. We evaluated the determinants for and long-term outcomes of extended DAPT and compared the occurrence of majo...
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Lee OH, Kim BK, Hong SJ, Kim S, Ahn CM, Shin DH, Kim JS, Kang TS, Ko YG, Choi D, Hong MK, Jang Y Tags: Yonsei Med J Source Type: research

Panel-Reactive and Donor-Specific Antibodies before Lung Transplantation can Affect Outcomes in Korean Patients Receiving Lung Transplantation.
CONCLUSION: Preoperative DSAs and PRAs are related to worse outcomes after lung transplantation. DSAs and PRAs should be considered when selecting lung transplant recipients, and recipients who have preoperative DSAs with high MFI values and high PRA levels should be monitored closely after lung transplantation. PMID: 32608204 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Moon SW, Park MS, Lee JG, Paik HC, Kim YT, Lee HJ, Park S, Choi SM, Kim DH, Cho WH, Yeo HJ, Park SI, Choi SH, Hong SB, Shim TS, Jo KW, Jeon K, Jeong BH, Kim SY, Korean Organ Transplantation Registry Study Group Tags: Yonsei Med J Source Type: research

Increasing Trend and Characteristics of Korean Adolescents Presenting to Emergency Department for Self-Harm: A 5-Year Experience, 2015 to 2019.
Abstract PURPOSE: Emergency department (ED) is a common treatment setting for adolescents with clinically serious self-harm. Here, we investigated the clinical characteristics and trends of adolescents with self-harm who visited the ED in one Korean university hospital. We also compared patients with a single ED visit to those with multiple ED visits to identify the risk factor of repeated visits. MATERIALS AND METHODS: We retrospectively identified patients aged 12 to 18 years who presented to ED for self-harm from January 2015 to December 2019, based on electronic medical records. Self-harm included all tho...
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Cheon J, Oh D, Lee J, Ahn J, Song DH, Cheon KA Tags: Yonsei Med J Source Type: research

Updates on Vaccine Safety and Post-Licensure Surveillance for Adverse Events Following Immunization in South Korea, 2005-2017.
CONCLUSION: The majority of reported AEFIs were non-serious and mostly general systemic reactions. Sufficient knowledge on the AEFIs would secure public confidence on the safety of vaccines, thereby reducing public health burden from vaccine-preventable diseases. PMID: 32608206 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Yoon D, Kim JH, Lee H, Shin JY Tags: Yonsei Med J Source Type: research

Protection of Healthcare Workers Against COVID-19 at a Large Teaching Hospital in Seoul, Korea.
Abstract Thirteen patients with coronavirus disease 2019 (COVID-19) visited a university hospital in Seoul before recognizing their disease infections, causing contact with 184 hospital workers. We classified the patients into four risk levels and provided corresponding management measures. At 31 days after the last event, all screening laboratory results were negative, and no symptoms/signs were reported. PMID: 32608207 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Jeon YW, Park ES, Jung SJ, Kim Y, Choi JY, Kim HC Tags: Yonsei Med J Source Type: research

Diagnosis and Operation Results for Chronic Lateral Ankle Instability with Subtle Cavovarus Deformity and a Peek-A-Boo Heel Sign.
Abstract Cavovarus deformity is considered an anatomical risk factor for chronic lateral ankle instability (CLAI). However, subtle deformity can be difficult to detect, and its correction is controversial. The current study aimed to evaluate clinical and radiographic outcomes of a modified Broström procedure (MBP) with additional procedures for CLAI with subtle cavovarus deformity and a positive peek-a-boo heel sign. We reviewed the records of 15 patients who underwent MBP with additional procedures for CLAI with a positive peek-a-boo heel sign between August 2009 and April 2015. Consecutive physical and radi...
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Shim DW, Suh JW, Park KH, Lee JW, Byun J, Han SH Tags: Yonsei Med J Source Type: research

Inequality in Life Expectancy in Korea according to Various Categorizations of the National Health Insurance Premiums as a Marker of Income.
In conclusion, we suggest that income quintile indicators in NHIS data, measured without distinguishing among types of beneficiaries, may best represent the magnitude of health inequalities in Korean society. This indicator could be used for future research on health inequalities, as well as for monitoring health inequalities in Korea. PMID: 32608209 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Bahk J, Kang HY, Khang YH Tags: Yonsei Med J Source Type: research

Is an Isolated Weight-Holding Tremor a New Subtype of Isometric Tremor?
Abstract A weight-holding tremor is a rare type of hand tremor that occurs only when someone holds some weight. Here we report three cases of isolated weight-holding tremors, of which one patient was diagnosed with Parkinson's disease (PD) and the others as a variant of essential tremor (ET). A 68-year-old woman presented with a left-hand tremor that appeared only when she held objects with some weight. Her tremor was reminiscent of the re-emergent tremor of PD, and dopamine transporter imaging revealed reduced uptake at the right posterior putamen. A 21-year-old man and a 71-year-old woman also presented with sim...
Source: Yonsei Medical Journal - July 1, 2020 Category: Universities & Medical Training Authors: Yong SW, Park DG, Yoon JH, Baik JS Tags: Yonsei Med J Source Type: research

Dr. Samuel Easton McManis (1891-1952), A Missionary Who Brought Together Preventive Medicine and Medical Evangelism.
PMID: 32469168 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Ahn SK, Koh SB, Lee S, Yoon JW Tags: Yonsei Med J Source Type: research

Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia.
CONCLUSION: RIC with busulfan and fludarabine is an effective and safe conditioning regimen for adult ALL patients unfit for myeloablation. PMID: 32469169 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Lee SS, Jung SH, Do YR, Kim DS, Lee JH, Park HS, Moon JH, Yi JH, Park Y, Koh Y, Yhim HY, Choi Y, Mun YC, Lee WS, Lee S, Yang DH, Korean Adult Acute Lymphoblastic Leukemia Working Party Tags: Yonsei Med J Source Type: research

MicroRNA-98-5p Inhibits Tumorigenesis of Hepatitis B Virus-Related Hepatocellular Carcinoma by Targeting NF- κB-Inducing Kinase.
CONCLUSION: MiR-98-5p inhibits the secretion of HBV, proliferation, migration, and invasion of HBV-HCC cells by targeting NIK. PMID: 32469170 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Fei X, Zhang P, Pan Y, Liu Y Tags: Yonsei Med J Source Type: research

Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
CONCLUSION: NMRAL2P activation suppresses ACOT7 expression in GC. Thus, ACOT7 could be a promising target for the treatment of GC. PMID: 32469171 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Feng H, Liu X Tags: Yonsei Med J Source Type: research

Does a Gradient-Adjusted Cardiac Power Index Improve Prediction of Post-Transcatheter Aortic Valve Replacement Survival Over Cardiac Power Index?
CONCLUSION: GCP did not improve the accuracy of predicting survival post TAVR at 1 year, compared to CP alone. PMID: 32469172 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Agasthi P, Pujari SH, Mookadam F, Tseng A, Venepally NR, Wang P, Allam M, Sweeney J, Eleid M, Fortuin FD, Holmes DR, Beohar N, Arsanjani R Tags: Yonsei Med J Source Type: research

Cellular Response of Ventricular-Subventricular Neural Progenitor/Stem Cells to Neonatal Hypoxic-Ischemic Brain Injury and Their Enhanced Neurogenesis.
CONCLUSION: HI promotes the establishment of a substantial number of new neurons in non-neurogenic regions, suggesting intrinsic repair mechanisms of the brain, by controlling the behavior of endogenous NSPCs. The activation of NeuroD1 expression may improve the therapeutic potential of endogenous NSPCs by increasing their neuronal differentiation in HI. PMID: 32469173 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Shin JE, Lee H, Jung K, Kim M, Hwang K, Han J, Lim J, Kim IS, Lim KI, Park KI Tags: Yonsei Med J Source Type: research

The Combined Impact of Chronic Kidney Disease and Diabetes on the Risk of Colorectal Cancer Depends on Sex: A Nationwide Population-Based Study.
This study was aimed to investigate the impact of CKD, DM, or both diseases on the risk of CRC and to evaluate sex differences therein. MATERIALS AND METHODS: Using data from the National Health Insurance Service-Health Examination Cohort in Korea, we conducted a 1:2 matched case-control study. The disease groups consisted of CKD-/DM+ (n=17700), CKD+/DM- (n=22643), and CKD+/DM+ groups (n=8506). After 1:2 matching by age, sex, and health examination year and month, the healthy control group consisted of 97698 individuals. RESULTS: Multivariate Cox regression analysis showed that the CKD-/DM+, CKD+/DM-, and CKD+/DM...
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Oh HJ, Lee HA, Moon CM, Ryu DR Tags: Yonsei Med J Source Type: research

Does Early Retrograde Intrarenal Surgery Improve the Cost-Effectiveness of Renal Stone Management?
CONCLUSION: Performing RIRS as early as possible can be recommended for eligible patients to reduce the overall failure, even if it is not as cost-effective as performing RIRS later. PMID: 32469175 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Yang SY, Jung HD, Kwon SH, Lee EK, Lee JY, Lee SH Tags: Yonsei Med J Source Type: research

Validation of a Multiplex Assay for Measuring Specific IgG4.
CONCLUSION: PROTIA™ Specific IgG4® showed high consistency with ImmunoCAP® in measuring sIgG4. This assay is applicable to various clinical fields, including allergen immunotherapy and food allergy. PMID: 32469176 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Kim SR, Park KH, Lee JE, Kim BJ, Lim KJ, Park JW Tags: Yonsei Med J Source Type: research

Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages.
CONCLUSION: Ethanol stimulates uric acid-induced NLRP3 inflammasome activation through regression of AhR and upregulation of TXNIP. PMID: 32469177 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Kim SK, Choe JY, Park KY Tags: Yonsei Med J Source Type: research

Successful Sirolimus Treatment for Korean Patients with Activated Phosphoinositide 3-kinase δ Syndrome 1: the First Case Series in Korea.
We describe three patients with APDS1, the first thereof in Korea. Therein, we investigated clinical manifestations of APDS1 and collected data on the efficacy and safety profile of sirolimus, a mammalian target of rapamycin inhibitor and pathway-specific targeted medicine. The same heterozygous PIK3CD mutation was detected in all three patients (E1021K). After genetic diagnosis, all patients received sirolimus and experienced an excellent response, including amelioration of lymphoproliferation and improvement of nodular mucosal lymphoid hyperplasia in the gastrointestinal tract. The median trough level of sirolimus was 5....
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Kang JM, Kim SK, Kim D, Choi SR, Lim YJ, Kim SK, Park BK, Park WS, Kang ES, Ko YH, Choe YH, Lee JW, Kim YJ Tags: Yonsei Med J Source Type: research

Selective Fascicular Involvement of the Median Nerve Trunk Causing Pseudo-Anterior Interosseous Nerve Syndrome: Ultrasound and MR Imaging Features.
We report three cases of focal anterior interosseous fascicular involvement in the median nerve trunk presenting as AIN palsy. Our report emphasizes the unique ultrasonographic and magnetic resonance imaging (MRI) features of swelling, hourglass-like constriction and torsion, and entwinement of the nerve fascicle of the dorsal region of the median nerve, which were confirmed surgically. On MRI, all patients showed denervation changes in the AIN territory, as well as in the median nerve territory, without compressing structures. PMID: 32469179 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Jung YY, Choi YS, Lee CH, Kwon O, Kim M Tags: Yonsei Med J Source Type: research

Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use.
Abstract Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. A 25-year-old male presented with headache and diplopia. He had taken 0.5 mg of dutasteride every other day for 9 months to treat alopecia. A headache developed 7 months after he started taking medication, and horizontal diplopia occurre...
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Authors: Choi BK, Cheon K, Cho BH, Jung JW, Lee KY Tags: Yonsei Med J Source Type: research

Erratum to "Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells" by Zhang X, et al. (Yonsei Med J 2018;59(5):633-642.).
Erratum to "Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells" by Zhang X, et al. (Yonsei Med J 2018;59(5):633-642.). Yonsei Med J. 2020 Jun;61(6):556 Authors: Abstract This corrects the article on p. 633 in vol. 59, PMID: 29869461. PMID: 32469181 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 30, 2020 Category: Universities & Medical Training Tags: Yonsei Med J Source Type: research

A Review of Pre-Exposure Prophylaxis Adherence among Female Sex Workers.
Abstract Globally and in Africa specifically, female sex workers (FSWs) are at an extraordinarily high risk of contracting human immunodeficiency virus (HIV). Pre-exposure prophylaxis (PrEP) has emerged as an effective and ethical method with which to prevent HIV infection among FSWs. PrEP efficacy is, however, closely linked to adherence, and adherence to PrEP among FSWs is a complex and interrelated process that has been shown to be of importance to public health policies and HIV control and intervention programs. This comprehensive review categorizes barriers to and facilitators of adherence to HIV PrEP for FSW...
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Ghayda RA, Hong SH, Yang JW, Jeong GH, Lee KH, Kronbichler A, Solmi M, Stubbs B, Koyanagi A, Jacob L, Oh H, Kim JY, Shin JI, Smith L Tags: Yonsei Med J Source Type: research

LncRNA LINC00313 Knockdown Inhibits Tumorigenesis and Metastasis in Human Osteosarcoma by Upregulating FOSL2 through Sponging miR-342-3p.
CONCLUSION: LINC00313 is upregulated in OS, and LINC00313 knockdown plays a vital anti-tumor role in OS cell progression through a miR-342-3p/FOSL2 axis. Our study suggests that LINC00313 may be a novel, promising biomarker for diagnosis and prognosis of OS. PMID: 32390359 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Chen H, Wahafu P, Wang L, Chen X Tags: Yonsei Med J Source Type: research

NUP210 and MicroRNA-22 Modulate Fas to Elicit HeLa Cell Cycle Arrest.
CONCLUSION: miR-22 in cervical cancer is downregulated, resulting in NUP210 overexpression and inhibition of Fas-induced cell apoptosis. PMID: 32390360 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Gu Q, Hou W, Liu H, Shi L, Zhu Z, Ye W, Ni X Tags: Yonsei Med J Source Type: research

Similar Clinical Outcomes of Early and Late Anti-TNF Initiation for Ulcerative Colitis: A Nationwide Population-Based Study.
CONCLUSION: Patients receiving early anti-TNF therapy had similar clinical outcomes to those of late initiators, suggesting that early anti-TNF therapy initiation offers little benefit in patients with UC. PMID: 32390361 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Han M, Jung YS, Cheon JH, Park S Tags: Yonsei Med J Source Type: research

Polymorphisms of Inflammatory Cytokine Genes and Risk for Intracranial Aneurysm: A Systematic Review and Meta-Analysis.
CONCLUSION: This review demonstrated an association between TNF-α rs1800629 polymorphism and IA in Caucasians, illustrating the potentially important role of genes involved in inflammation in IA. PMID: 32390362 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Hu L, Li B, Liao X, Yan J Tags: Yonsei Med J Source Type: research

Blood Supply and Demand in Korea: What is in Store for the Future?
CONCLUSION: Blood management in Korea is changing rapidly due to a low birth rate, rapid aging, and an increase in severely ill patients who require most of the blood supply. Therefore, future plans to promote donation at a national level and optimal use of blood in hospitals is necessary. PMID: 32390363 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Roh J, Choi SJ, Kim S, Min H, Kim HO Tags: Yonsei Med J Source Type: research

Contribution of Personality Traits, Psychological Factors, and Health-Related Quality of Life to Medication Adherence in Patients with Rheumatoid Arthritis.
CONCLUSION: The personality trait of conscientiousness was associated with medication adherence among the five personality traits evaluated. Patients with diabetes mellitus also showed higher medication adherence than those without this comorbidity. PMID: 32390364 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Ko KM, Moon SJ, Koh JH, Pae CU, Min JK Tags: Yonsei Med J Source Type: research

An Automated Fast Healthcare Interoperability Resources-Based 12-Lead Electrocardiogram Mobile Alert System for Suspected Acute Coronary Syndrome.
Abstract PURPOSE: For patients with time-critical acute coronary syndrome, reporting electrocardiogram (ECG) findings is the most important component of the treatment process. We aimed to develop and validate an automated Fast Healthcare Interoperability Resources (FHIR)-based 12-lead ECG mobile alert system for use in an emergency department (ED). MATERIALS AND METHODS: An automated FHIR-based 12-lead ECG alert system was developed in the ED of an academic tertiary care hospital. The system was aimed at generating an alert for patients with suspected acute coronary syndrome based on interpretation by the leg...
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Hur S, Lee J, Kim T, Choi JS, Kang M, Chang DK, Cha WC Tags: Yonsei Med J Source Type: research

Survey of Risk-Based Quality Management Status and Establishment of Operational Model in Clinical Trials.
CONCLUSION: In the future, organizations conducting clinical and subsequent pilot studies trials in South Korea should follow these quality management practice to share information with each other. PMID: 32390366 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Kim E, Lim C Tags: Yonsei Med J Source Type: research

Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study.
Abstract Although some information on the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a few selected cases has been reported, data on the clinical characteristics and outcomes of patients hospitalized therewith in South Korea are lacking. We conducted a retrospective single-center study of 98 consecutive hospitalized patients with confirmed SARS-CoV-2 infection at Yeungnam University Medical Center in Daegu, South Korea. Sixty patients were women (61.2%), and the mean age was 55.4±17.1 years. Thirteen patients (13.3%) were treated in the intensive care unit (ICU). The me...
Source: Yonsei Medical Journal - May 1, 2020 Category: Universities & Medical Training Authors: Hong KS, Lee KH, Chung JH, Shin KC, Choi EY, Jin HJ, Jang JG, Lee W, Ahn JH Tags: Yonsei Med J Source Type: research