Circular RNAs Regulate Cancer Onset and Progression via Wnt/ β-Catenin Signaling Pathway.
Circular RNAs Regulate Cancer Onset and Progression via Wnt/β-Catenin Signaling Pathway. Yonsei Med J. 2019 Dec;60(12):1117-1128 Authors: Li YF, Zhang J, Yu L Abstract Cancer remains to be a major challenge for public health providers, and is the second leading cause of death worldwide. Therefore, it is imperative to explore the mechanisms underlying cancer initiation and development, and design novel diagnostics and therapeutics. Circular RNAs (circRNAs), which exhibit a covalently closed loop structure, are involved in a variety of diseases, including cancer. The aberrant expression of circRNAs...
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Li YF, Zhang J, Yu L Tags: Yonsei Med J Source Type: research

Impact of Cerebrovascular Disease on Survival Benefits from Local Treatment in Patients with De Novo Metastatic Hormone-Sensitive Prostate Cancer.
Abstract PURPOSE: Local treatment has become a treatment option for patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC). Subgroup analyses based on a history of cerebrovascular disease (CVD) were performed to evaluate the impact thereof on overall survival (OS) after local treatment. MATERIALS AND METHODS: A retrospective analysis was performed for 879 patients with de novo mHSPC between August 2003 and November 2016. Patients were stratified according to prior CVD history and the type of initial treatment: androgen-deprivation therapy (ADT) alone versus local treatment consisting of ra...
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Kim TJ, Yu YD, Park DS, Rha KH, Hong SJ, Cho KS, Chung BH, Koo KC Tags: Yonsei Med J Source Type: research

Oncologic Outcomes of Extended Lymphadenectomy without Liver Resection for T1/T2 Gallbladder Cancer.
CONCLUSION: Our results suggest that the current operative protocol can be applied to minimal invasive operations for GBC with similar oncologic outcomes as open approach. For T1/T2 GBC, radical cholecystectomy, including para-aortic lymph node dissection, can be performed safely with favorable oncologic outcomes. PMID: 31769244 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Chong JU, Lee WJ Tags: Yonsei Med J Source Type: research

MiR-338-3p Enhances Ovarian Cancer Cell Sensitivity to Cisplatin by Downregulating WNT2B.
CONCLUSION: MiR-338-3p enhances the sensitivity of ovarian cancer cells to cisplatin by downregulating WNT2B. PMID: 31769245 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Niu Q, Liu Z, Gao J, Wang Q Tags: Yonsei Med J Source Type: research

Cost-Effectiveness of Rate- and Rhythm-Control Drugs for Treating Atrial Fibrillation in Korea.
CONCLUSION: Propranolol and pilsicainide appear to be cost-effective in patients with AF in Korea assuming that drug usage or compliance is the same. PMID: 31769246 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Kim M, Kim W, Kim C, Joung B Tags: Yonsei Med J Source Type: research

Controlling Nutritional Status Score is Associated with All-Cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
CONCLUSION: CONUT score at diagnosis is associated with all-cause mortality in AAV patients. PMID: 31769247 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Ahn SS, Jung SM, Song JJ, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

Serum Procollagen Type I N-Terminal Propeptide and Osteocalcin Levels in Korean Children and Adolescents.
Abstract PURPOSE: Bone markers can be useful for the diagnosis and treatment of skeletal diseases in children and adolescents. Owing to high skeletal growth velocity and rapid bone turnover, children and adolescents have higher bone marker levels than adults. Thus, a valid age- and sex-specific reference should be established for pediatric populations living in similar environments. We aimed to assess the associations of procollagen type I N-terminal propeptide (P1NP) and osteocalcin with age and sex in a group of healthy Korean children and adolescents. MATERIALS AND METHODS: The participants (290 boys and 2...
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Choi JS, Park I, Lee SJ, Ju HJ, Lee H, Kim J Tags: Yonsei Med J Source Type: research

Correlations between Aspiration and Pharyngeal Residue Scale Scores for Fiberoptic Endoscopic Evaluation and Videofluoroscopy.
Abstract PURPOSE: To examine correlations among rating scales and findings suggestive of tracheal aspiration and pharyngeal residue between fiberoptic endoscopic evaluation of swallowing (FEES) and videofluoroscopic swallowing study (VFSS) in dysphagia patients. MATERIALS AND METHODS: We studied patients referred to our hospital for dysphagia assessment. Three raters judged the residue severity and laryngeal penetration or tracheal aspiration of FEES and VFSS. The raters applied the Penetration-Aspiration Scale (PAS) for tracheal aspiration and pixel-based circumscribed area ratio and Yale Pharyngeal Residue ...
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Yoon JA, Kim SH, Jang MH, Kim SD, Shin YB Tags: Yonsei Med J Source Type: research

MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase.
CONCLUSION: Upregulation of miR-138 inhibits adipogenic differentiation of hAMSCs by directly downregulating LPL. PMID: 31769250 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P Tags: Yonsei Med J Source Type: research

Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation.
CONCLUSION: These results suggest that propofol could attenuate hypoxia/reoxygenation induced apoptosis and autophagy in HK-2 cells, probably through inhibiting JNK activation. PMID: 31769251 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Wang H, Peng X, Huang Y, Xiao Y, Wang Z, Zhan L Tags: Yonsei Med J Source Type: research

Effect of Statin Use on Liver Cancer Mortality Considering Hypercholesterolemia and Obesity in Patients with Non-Cirrhotic Chronic Hepatitis B.
This study showed that statin use was associated with decreased liver cancer mortality when adjusting for cholesterol levels and BMI. This study found that hypercholesterolemia was independently associated with decreased liver cancer mortality regardless of statin use. PMID: 31769252 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Kim GA, Shim JJ, Lee JS, Kim BH, Kim JW, Oh CH, Oh CM, Oh IH, Park SY Tags: Yonsei Med J Source Type: research

Diagnostic Challenges Associated with GLUT1 Deficiency: Phenotypic Variabilities and Evolving Clinical Features.
Abstract GLUT1 deficiency is a rare neurometabolic disorder that can be effectively treated with ketogenic diet. However, this condition is underdiagnosed due to its nonspecific, overlapping, and evolving symptoms with age. We retrospectively reviewed the clinical course of nine patients diagnosed with GLUT1 deficiency, based on SLC2A1 mutations and/or glucose concentration in cerebrospinal fluid. The patients included eight boys and one girl who initially presented with seizures (44%, 4/9) or delayed development (44%, 4/9) before 2 years of age, except for one patient who presented with apnea as a neonate. Over t...
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Kim H, Lee JS, Lee Y, Kim SY, Lim BC, Kim KJ, Choi M, Chae JH Tags: Yonsei Med J Source Type: research

The Multi-Institutional Health Screening Records Database of South Korea: Description and Evaluation of Its Characteristics.
This study sought to describe and to evaluate the characteristics of the Health Screening Records Database (HSRD) of the Korea Association of Health Promotion as a data source for epidemiologic studies. The HSRD was compared to a National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) database for 2015. Common variables between the databases were selected, and sex-based analyses were conducted. The HSRD showed statistical concordance when NHIS-HEALS estimates fell within the HSRD estimate's 95% confidence interval. The HSRD and NHIS-HEALS included 946461 and 111690 participants in health screening programs, ...
Source: Yonsei Medical Journal - November 28, 2019 Category: Universities & Medical Training Authors: Noh Y, Jeong HE, Kim HJ, Ko H, Nah EH, Shin JY Tags: Yonsei Med J Source Type: research

Methionyl-tRNA Synthetase is a Useful Diagnostic Marker for Lymph Node Metastasis in Non-Small Cell Lung Cancer.
CONCLUSION: MRS/CD45 dual IF staining showed good diagnostic performance and may be a good tool complementing conventional cytology test for determining LN metastasis of NSCLC. PMID: 31637881 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Lee JM, Kim T, Kim EY, Kim A, Lee DK, Kwon NH, Kim S, Chang YS Tags: Yonsei Med J Source Type: research

A Two-DNA Methylation Signature to Improve Prognosis Prediction of Clear Cell Renal Cell Carcinoma.
CONCLUSION: The two-DNA methylation signature was deemed to be a potential novel prognostic biomarker of use in increasing the accuracy of predicting overall survival of ccRCC patients. PMID: 31637882 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Shi S, Ye S, Wu X, Xu M, Zhuo R, Liao Q, Xi Y Tags: Yonsei Med J Source Type: research

Neutrophil-to-Lymphocyte Ratio Predicts Pathological Renal Sinus Fat Invasion in Renal Cell Carcinomas of ≤7 cm with Presumed Renal Sinus Fat Invasion.
Neutrophil-to-Lymphocyte Ratio Predicts Pathological Renal Sinus Fat Invasion in Renal Cell Carcinomas of ≤7 cm with Presumed Renal Sinus Fat Invasion. Yonsei Med J. 2019 Nov;60(11):1021-1027 Authors: Kim J, Park JS, Heo JE, Elghiaty A, Jang WS, Rha KH, Choi YD, Ham WS Abstract PURPOSE: Computed tomography (CT) is the most useful diagnostic modality for staging renal cell carcinoma (RCC). However, CT is limited in its ability to predict renal sinus fat invasion (SFI). Here, we aimed to evaluate whether preoperative neutrophil-to-lymphocyte ratio (NLR) could predict pathological SFI in patients with...
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Kim J, Park JS, Heo JE, Elghiaty A, Jang WS, Rha KH, Choi YD, Ham WS Tags: Yonsei Med J Source Type: research

An Updated Nomogram for Predicting Invasiveness in Preoperative Ductal Carcinoma In Situ of the Breast.
CONCLUSION: The previous nomogram did not effectively discriminate upstaging of preoperative DCIS in an independent cohort. An updated version of the nomogram appears to provide more accurate information for predicting preoperative DCIS upstaging. PMID: 31637884 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Kim S, Kim J, Park HS, Kim HY, Lee K, Lee J, Lee H, Kim JY, Kim SI, Cho YU, Park BW Tags: Yonsei Med J Source Type: research

Adipose-Derived Stem Cell Transplantation Inhibits Vascular Inflammatory Responses and Endothelial Dysfunction in Rats with Atherosclerosis.
CONCLUSION: Our study demonstrated that ADSC transplantation could inhibit vascular inflammatory responses and endothelial dysfunction by suppressing NF-κB pathway in AS rats. PMID: 31637885 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Fan M, Bai J, Ding T, Yang X, Si Q, Nie D Tags: Yonsei Med J Source Type: research

TNF α Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis.
CONCLUSION: Our findings indicated that TNFα induces hepatic MRP4 expression through activation of the p38-E2F1-Nrf2 signaling pathway in human obstructive cholestasis. PMID: 31637886 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Lian W, Liu X, Chen W Tags: Yonsei Med J Source Type: research

Quality Indicators and Outcome Measures of Endoscopy in the National Cancer Screening Program.
This study was conducted between March and August 2018 in primary, secondary, and tertiary healthcare facilities that perform endoscopy as a part of the NCSP. Representative endoscopists completed a questionnaire for quality indicators of the NEQIP and provided data on outcome measures for endoscopy. RESULTS: Quality indicators of the NEQIP were mostly acceptable. However, the quality indicators for annual volume of esophagogastroduodenoscopy (EGD) and colonoscopy, training for endoscopy quality improvement by endoscopy nursing staff, colonoscopy reports, documentation of pathologic lesions, quality of endoscopy repro...
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Min JK, Cha JM, Kwak MS, Yoon JY, Jung Y, Shin JE, Yang HJ Tags: Yonsei Med J Source Type: research

Implementation of a Targeted Next-Generation Sequencing Panel for Constitutional Newborn Screening in High-Risk Neonates.
CONCLUSION: The implementation of TNGS in conjunction with conventional NBS can allow for better management of and earlier diagnosis in susceptible infants, thus preventing the development of critical conditions in these sick infants. PMID: 31637888 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Lee H, Lim J, Shin JE, Eun HS, Park MS, Park KI, Namgung R, Lee JS Tags: Yonsei Med J Source Type: research

Bone Flap Changes after Cranioplasty Using Frozen Autologous Bone Flaps: A Three-Dimensional Volumetric Reconstruction Study.
This study aimed to evaluate changes in ABFs following cranioplasty and to investigate factors related with BFR. MATERIALS AND METHODS: We retrospectively reviewed 97 patients who underwent cranioplasty with frozen ABF between January 2007 and December 2016. Brain CT images of these patients were reconstructed to form three-dimensional (3D) images, and 3D images of ABF were separated using medical image editing software. ABF volumes on images were measured using 3D image editing software and were compared between images in the immediate postoperative period and at postoperative 12 months. Risk factors related with BFR...
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Lee JH, Chough CK, Choi HJ, Ko JK, Cho WH, Cha SH, Choi CH, Kim YH Tags: Yonsei Med J Source Type: research

Manchester Operation: An Effective Treatment for Uterine Prolapse Caused by True Cervical Elongation.
CONCLUSION: The Manchester operation technique seems to be an effective and safe alternative procedure for the treatment of uterine prolapse caused by true cervical elongation, compared with VH. PMID: 31637890 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Park YJ, Kong MK, Lee J, Kim EH, Bai SW Tags: Yonsei Med J Source Type: research

LncRNA MALAT1/MiR-145 Adjusts IL-1 β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis.
CONCLUSION: An MALAT1/miR-145 axis contributes to ECM degradation in IL-1β-induced chondrocytes through targeting ADAMTS5, suggesting that MALAT1/miR-145/ADAMTS5 signaling may underlie human OA pathogenesis. PMID: 31637891 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Liu C, Ren S, Zhao S, Wang Y Tags: Yonsei Med J Source Type: research

Invasive Pneumococcal Disease Caused by Non-Vaccine Type Multidrug-Resistant Streptococcus pneumoniae Transmitted by Close Contact in a Healthy Adult.
In this study, we report an invasive pneumococcal disease (IPD) caused by NVT multidrug-resistant (MDR) S. pneumoniae transmitted from a vaccinated infant to an unvaccinated healthy woman, and the clinical characteristics of this serotype. A 29-year-old previously healthy woman visited our hospital with fever and headache. She had been breastfeeding her baby for 8 months. She was diagnosed with brain abscess and sinusitis caused by S. pneumoniae. Although the patient had no previous exposure to antibiotics, antibiotic susceptibility test identified the pathogen as MDR. The patient's family members were examined using nasop...
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Yoo JR, Oh S, Lee JG, Kim YR, Lee KH, Heo ST Tags: Yonsei Med J Source Type: research

Consecutive Jailed- and Kissing-Corsair Technique: Side Branch Protection and Dilation during Stent Implantation.
We describe a novel technique, consecutive jailed- and kissing-Corsair technique, using a Corsair microcatheter for protection of side branches in bifurcation lesions. PMID: 31637894 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Choi J, Kim BK, Hong SJ, Hong MK, Jang Y Tags: Yonsei Med J Source Type: research

Feasibility and Effectiveness of Direct Puncture and Onyx Embolization for Transverse Sinus Dural Arteriovenous Fistula.
We report a case of DAVF at the left TS that was treated with Onyx embolization via direct puncture of the TS. A 75-year-old woman presented with tremor, festinating gait, and dysarthria. A left TS-DAVF with retrograde superior sagittal sinus and cortical venous reflux (Cognard type IIa+b) was identified on cerebral angiography, and both TSs were occluded with thrombi. We considered that achieving complete cure by transvenous embolization via the femoral vein or transarterial embolization via occipital feeders would be difficult. Thus, we performed a small craniotomy at the occipital bone to puncture the TS. The midportion...
Source: Yonsei Medical Journal - October 24, 2019 Category: Universities & Medical Training Authors: Nam TK, Byun JS, Choi HH, Chung MS, Lee EJ Tags: Yonsei Med J Source Type: research

Dr. Sa Young Ahn (1890-1968), A Compassionate Devotion to Humanity.
PMID: 31538422 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Park KS, Park YS, Yoon J, Koh SB, Ahn SK Tags: Yonsei Med J Source Type: research

"Hairiness" is a Facsimile of Reorganized Cytoskeletons: A Cytopathic Effect of Coxiella burnetii.
"Hairiness" is a Facsimile of Reorganized Cytoskeletons: A Cytopathic Effect of Coxiella burnetii. Yonsei Med J. 2019 Oct;60(10):890-897 Authors: Lee WY Abstract In 1993, I reported that Coxiella burnetii transforms human B cells into hairy cells (cbHCs), the first hairy cell reported outside of hairy cell leukemia (HCL). Over last few decades, advances in molecular biology have provided evidence supporting that C. burnetii induces hairiness and inhibits the apoptosis of host cells. The present review summarizes new information in support of cbHC. C. burnetii was shown to induce reorganizati...
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Lee WY Tags: Yonsei Med J Source Type: research

Sonic Hedgehog Pathway as the Prognostic Marker in Patients with Extensive Stage Small Cell Lung Cancer.
CONCLUSION: A high proportion of small cell lung cancer tumors express proteins related to Shh pathway, and over-expression of Shh is correlated with poor prognosis. PMID: 31538424 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Lim S, Lim SM, Kim MJ, Park SY, Kim JH Tags: Yonsei Med J Source Type: research

The Long Non-Coding RNA CASC2 Suppresses Cell Viability, Migration, and Invasion in Hepatocellular Carcinoma Cells by Directly Downregulating miR-183.
CONCLUSION: CASC2 inhibited cell viability and the colony formation, migration, and invasion abilities of HCC cells by directly downregulating miR-183 through inactivation of the Wnt/β-catenin signaling pathway. PMID: 31538425 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Sun J, Liu L, Zou H, Yu W Tags: Yonsei Med J Source Type: research

Integrating a Next Generation Sequencing Panel into Clinical Practice in Ovarian Cancer.
CONCLUSION: Implementation of NGS may help in identifying patients who might benefit from targeted treatment therapies and genetic counseling. PMID: 31538426 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Lee YJ, Kim D, Kim HS, Na K, Lee JY, Nam EJ, Kim SW, Kim S, Kim YT Tags: Yonsei Med J Source Type: research

microRNA-146a Promotes Growth of Acute Leukemia Cells by Downregulating Ciliary Neurotrophic Factor Receptor and Activating JAK2/STAT3 Signaling.
CONCLUSION: miR-146a could promote the proliferation, migration, and invasion and inhibit the apoptosis of AL Jurkat and HL-60 cells by downregulating CNTFR and activating the JAK2/STAT3 pathway. PMID: 31538427 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Wang L, Zhang H, Lei D Tags: Yonsei Med J Source Type: research

Distinct Neural Correlates of Executive Function by Amyloid Positivity and Associations with Clinical Progression in Mild Cognitive Impairment.
CONCLUSION: Our findings suggest that although MCI subjects showed similar behavioral phenotypes at the time of diagnosis, EF and further progression were associated with different brain regions according to Aβ burden. Clarification of the etiologies and nature of EF impairment in aMCI are critical for disease prognosis and management. PMID: 31538428 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Yoon HJ, Kim SG, Kim SH, Choo ILH, Park SH, Seo EH, Alzheimer's Disease Neuroimaging Initiative Tags: Yonsei Med J Source Type: research

Various Treatment Modalities in Hepatic Hydrothorax: What Is Safe and Effective?
CONCLUSION: Serial thoracentesis may be recommended for management of hepatic hydrothorax and surgical management can be a useful option in patients with refractory hepatic hydrothorax, alternative to pigtail drainage. PMID: 31538429 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Yoon JH, Kim HJ, Jun CH, Cho SB, Jung Y, Choi SK Tags: Yonsei Med J Source Type: research

The Effects of Short-Term and Very Short-Term Particulate Matter Exposure on Asthma-Related Hospital Visits: National Health Insurance Data.
CONCLUSION: We found a significant association between short-term and very short-term PM exposure exceeding the current daily average environmental standards of Korea and asthma-related hospital visits. These results are expected to aid in establishing appropriate environmental standards and relevant policies for PM. PMID: 31538430 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Song DJ, Choi SH, Song WJ, Park KH, Jee YK, Cho SH, Lim DH Tags: Yonsei Med J Source Type: research

Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen-Food Allergy Syndrome.
In this study, we investigated the clinical manifestations and risk factors for anaphylaxis in PFAS in Korean patients with pollinosis. MATERIALS AND METHODS: Data were obtained from a nationwide cross-sectional study that previously reported on PFAS in Korean patients with pollinosis. Data from 273 patients with PFAS were collected, including demographics, list of culprit fruits and vegetables, and clinical manifestations of food allergy. We analyzed 27 anaphylaxis patients and compared them with patients with PFAS with oropharyngeal symptoms only (n=130). RESULTS: The most common cause of anaphylaxis in PFAS wa...
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Kim M, Ahn Y, Yoo Y, Kim DK, Yang HJ, Park HS, Lee HJ, Kim MA, Jeong YY, Kim BS, Bae WY, Jang AS, Park Y, Koh YI, Lee J, Lim DH, Kim JH, Lee SM, Kim YM, Jun YJ, Kim HY, Kim Y, Choi JH, Work Group for Rhinitis, the Korean Academy of Asthma, Allergy and Cli Tags: Yonsei Med J Source Type: research

Incidence and Mortality of Osteoporotic Refractures in Korea according to Nationwide Claims Data.
The objectives of this research were: 1) to determine the incidence of osteoporotic refractures and fracture locations and 2) to assess mortality rates associated with osteoporotic refracture over a median follow up of 3 years using nationwide claim database. MATERIALS AND METHODS: Patients over 50 years of age who had an osteoporotic fracture that was confirmed operationally were enrolled. Refracture was defined as that after 6 months of an untreated period. Mortality rate was calculated using the Charlson comorbidity index and was analyzed using Cox proportional hazards regression analysis. RESULTS: A total of ...
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Yoo JI, Ha YC, Park KS, Kim RB, Seo SH, Koo KH Tags: Yonsei Med J Source Type: research

Impacts of Financial Coverage on Long-Term Outcome of Intensive Care Unit Survivors in South Korea.
CONCLUSION: This study showed that 1-year mortality was higher in ICU survivors with low economic status, even if financial coverage was provided by the government. Our result suggests the necessity of a more nuanced and multifaceted approach to policy for ICU survivors with low economic status. PMID: 31538433 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Cha JK, Oh TK, Song IA Tags: Yonsei Med J Source Type: research

Continuous Renal Replacement Therapy in Preterm Infants.
CONCLUSION: Our data suggest that the degree of immaturity, cardiopulmonary instability, and fluid overload affect the prognosis of preterm infants after CRRT. Preventing fluid overload and earlier initiation of CRRT may improve treatment outcomes. PMID: 31538434 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Noh ES, Kim HH, Kim HS, Han YS, Yang M, Ahn SY, Sung SI, Chang YS, Park WS Tags: Yonsei Med J Source Type: research

Characteristics of Lung Allocation and Outcomes of Lung Transplant according to the Korean Urgency Status.
CONCLUSION: The Korean urgency classification for LTx is determined by using very limited parameters and may not be a true reflection of urgency. Status 0 patients seem to have poor outcomes compared to the other urgency status patients, despite having the highest priority for donor lungs. Further multi-center and nationwide studies are needed to revise the lung allocation system to reflect true urgency and provide the best benefit of lung transplantation. PMID: 31538435 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Yu WS, Kim SY, Kim YT, Lee HJ, Park S, Choi SM, Kim DH, Cho WH, Yeo HJ, Park SI, Choi SH, Hong SB, Shim TS, Jo KW, Jeon K, Jeong BH, Paik HC, Lee JG, Korean Organ Transplantation Registry Study Group Tags: Yonsei Med J Source Type: research

Why Do Japan and South Korea Record Very Low Levels of Perceived Health Despite Having Very High Life Expectancies?
This study extracted data from Health at a Glance 2017 by the OECD for 26 countries with valid and comparable information on LE, SRH, and the number of doctor consultations per capita. Correlations among LE, good SRH, and number of doctor consultations per capita were analyzed. The number of annual doctor consultations per capita and the prevalence of good SRH were closely correlated (correlation coefficient=-0.610); excluding outliers produced a higher correlation coefficient (-0.839). Similar patterns were observed when we replaced good SRH with poor SRH. Meanwhile, the correlation coefficient between annual per capita d...
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Kim M, Khang YH Tags: Yonsei Med J Source Type: research

Hyo-Kyu Kim (1917-1999): The One Who Constructed Gangnam Severance Hospital and Reformed Yonsei University Health System.
PMID: 31433578 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Kim BS Tags: Yonsei Med J Source Type: research

Prevalence, Characteristics, and Clinical Significance of Concomitant Cardiomyopathies in Subjects with Bicuspid Aortic Valves.
Abstract PURPOSE: The present study aimed to investigate the prevalence, characteristics, and clinical significance of concomitant specific cardiomyopathies in subjects with bicuspid aortic valves (BAVs). MATERIALS AND METHODS: A total of 1186 adults with BAV (850 males, mean age 56±14 years) at a single tertiary center were comprehensively reviewed. Left ventricular non-compaction, hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy were confirmed when patients fulfilled current clinical and echocardiographic criteria. Clinical and echocardiographic characteristics, including comorbidit...
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Jeong H, Shim CY, Kim D, Choi JY, Choi KU, Lee SY, Hong GR, Ha JW Tags: Yonsei Med J Source Type: research

Coronary Artery Aneurysm after Second-Generation Drug-Eluting Stent Implantation.
Abstract PURPOSE: We evaluated the incidence, predictors, and prognosis of coronary artery aneurysm (CAA) after second-generation drug-eluting stent (DES) implantation. MATERIALS AND METHODS: A total of 976 consecutive patients (1245 lesions) who underwent follow-up angiography after second-generation DES implantation were analyzed. Incidence and predictors of CAA were assessed, and clinical prognosis was compared with 34 cases of CAA after first-generation DES implantation using previous CAA registry data. RESULTS: All 10 cases of CAA (0.80% per lesion) in 10 patients (1.02% per patient) were detected a...
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Hong SJ, Kim H, Ahn CM, Kim JS, Kim BK, Ko YG, Hong BK, Choi D, Jang Y, Hong MK Tags: Yonsei Med J Source Type: research

miR-1301/TRIAP1 Axis Participates in Epirubicin-Mediated Anti-Proliferation and Pro-Apoptosis in Osteosarcoma.
CONCLUSION: miR-1301 was implicated in the chemosensitivity of osteosarcoma to epirubicin by modulating TRIAP1. PMID: 31433581 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Yu L, Meng M, Bao Y, Zhang C, Gao B, Sa R, Luo W Tags: Yonsei Med J Source Type: research

Long Intergenic Non-Protein Coding RNA 665 Regulates Viability, Apoptosis, and Autophagy via the MiR-186-5p/MAP4K3 Axis in Hepatocellular Carcinoma.
CONCLUSION: LINC00665 was involved in cell viability, apoptosis, and autophagy in HCC via miR-186-5p/MAP4K3 axis, which may provide a new approach for HCC treatment. PMID: 31433582 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Shan Y, Li P Tags: Yonsei Med J Source Type: research

Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model.
CONCLUSION: These results support a prominent role for RLX in scar remodeling and suggest that gel/Ad-RLX may have therapeutic effects on scar formation. PMID: 31433583 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Yun IS, Kang E, Ahn HM, Kim YO, Rah DK, Roh TS, Lee WJ, Yun CO Tags: Yonsei Med J Source Type: research

Laparoendoscopic Single Site Surgery for the Treatment of Huge Ovarian Cysts Using an Angiocatheter Needle.
CONCLUSION: LESS surgery using an angiocatheter needle, with leaving only a small postoperative scar, was deemed feasible for the management of huge ovarian cysts. PMID: 31433584 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Ki EY, Park EK, Jeong IC, Bak SE, Hwang HS, Chung YH, Song MJ Tags: Yonsei Med J Source Type: research

Prevalence of Upper Extremity Musculoskeletal Diseases and Disability among Fruit Tree Farmers in Korea: Cross-Sectional Study.
Abstract PURPOSE: The aim of this study was to examine the prevalence of upper extremity musculoskeletal (MSK) diseases and to identify factors influencing disability among fruit tree farmers in Korea. MATERIALS AND METHODS: Of the 1150 subjects of the Namgaram study, 460 fruit tree farmers completed a questionnaire and underwent clinical evaluations, including physical assessments, laboratory tests, simple radiographic examinations, and magnetic resonance imaging studies of the upper extremities. Disability was assessed using the Disabilities of the Arm, Shoulder, and Hand outcome measure. Data were analyzed...
Source: Yonsei Medical Journal - August 23, 2019 Category: Universities & Medical Training Authors: Kim M, Yoo JI, Kim MJ, Na JB, Lee SI, Park KS Tags: Yonsei Med J Source Type: research