"The 34th National Representative," Dr. Frank W. Schofield (1889-1970).
"The 34th National Representative," Dr. Frank W. Schofield (1889-1970). Yonsei Med J. 2019 Apr;60(4):315-318 Authors: Sihn KH PMID: 30900416 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Sihn KH Tags: Yonsei Med J Source Type: research

Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression.
Abstract Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and its high rates of relapse and metastasis are associated with a poor prognosis. Despite extensive research, the underlying regulatory mechanisms of CRC remain unclear. Long noncoding RNAs (lncRNAs) are a major type of noncoding RNAs that have received increasing attention in the past few years, and studies have shown that they play a role in many biological processes in CRC. Here, we summarize recent studies on lncRNAs associated with CRC and the signaling pathways and mechanisms underlying this association. We s...
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Tang X, Qiao X, Chen C, Liu Y, Zhu J, Liu J Tags: Yonsei Med J Source Type: research

Potential Oncogenic Role of the Papillary Renal Cell Carcinoma Gene in Non-Small Cell Lung Cancers.
In this study, we aimed to identify the profiles of PRCC expression in Korean NSCLC patients and to elucidate the role of PRCC overexpression on lung tumorigenesis. MATERIALS AND METHODS: We performed immunohistochemistry analysis with a tissue array containing 161 primary NSCLCs. Small interfering RNA targeting PRCC (siPRCC) was transfected into two lung cancer cell lines (NCI-H358 and A549), after which tumor growth, migration, and invasion were observed. Expressions of cell proliferation-, cell cycle-, and metastasis-related molecules were examined by Western blot analysis. We also explored the in vivo effect of PR...
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Jang SH, Jiang Y, Shin S, Jung SH, Jung CK, Chung YJ Tags: Yonsei Med J Source Type: research

The Long Noncoding RNA NEAT1 Targets miR-34a-5p and Drives Nasopharyngeal Carcinoma Progression via Wnt/ β-Catenin Signaling.
CONCLUSION: Our study demonstrated that NEAT1 targets miR-34a-5p at least partly to drive NPC progression by regulating Wnt/β-catenin signaling, suggesting a potential therapeutic target for NPC. PMID: 30900419 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Ji Y, Wang M, Li X, Cui F Tags: Yonsei Med J Source Type: research

Effectiveness of Bi-Parametric MR/US Fusion Biopsy for Detecting Clinically Significant Prostate Cancer in Prostate Biopsy Na ïve Men.
CONCLUSION: bpMRI is a feasible tool with which to identify sPCa. MR/US fusion biopsy, rather than systemic biopsy, can help identify sPCa. We recommend using supplemental tools to increase prostate cancer detection in patients with PI-RADS 3 lesions. PMID: 30900420 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Kim YJ, Huh JS, Park KK Tags: Yonsei Med J Source Type: research

Regulatory Mechanism of MicroRNA-145 in the Pathogenesis of Acute Aortic Dissection.
CONCLUSION: miR-145 suppressed the progression of AAD by targeting CTGF, suggesting that a miR-145/CTGF axis may provide a potential therapeutic target for AAD. PMID: 30900421 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Li T, Liu C, Liu L, Xia H, Xiao Y, Wang X, Wang Y Tags: Yonsei Med J Source Type: research

Unilateral versus Bilateral Groin Puncture for Atrial Fibrillation Ablation: Multi-Center Prospective Randomized Study.
CONCLUSION: UG-ST AF ablation is feasible and safe, and was found to significantly reduce post-procedural hemostasis-related discomfort, compared to the conventional DT approach, in patients with paroxysmal AF. PMID: 30900422 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Yu HT, Shin DG, Shim J, Nam GB, Yoo WW, Lee JH, Kim TH, Uhm JS, Joung B, Lee MH, Kim YH, Pak HN Tags: Yonsei Med J Source Type: research

Performance of Three Scoring Systems in Predicting Massive Transfusion in Patients with Unstable Upper Gastrointestinal Hemorrhage.
CONCLUSION: In unstable UGIB patients, MEW score had the best prognostic performance for MT among three scoring systems. PMID: 30900423 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Lee DH, Lee KM, Lee SM, Lee BK, Cho YS, Choi G, Yun SW Tags: Yonsei Med J Source Type: research

A Feasibility Study for Diagnosis of Latent Tuberculosis Infection Using an IGRA Point-of-Care Platform in South Korea.
This study aimed to evaluate ichroma™ IGRA-TB, a novel point-of-care platform for assaying IFN-γ release, and to compare it with QuantiFERON-TB Gold In-Tube (QFT-GIT) for identifying Mycobacterium tuberculosis (M. tb) infection. MATERIALS AND METHODS: We recruited 60 healthy subjects, and blood samples were obtained in QFT-GIT blood collection tubes. The blood collection tubes were incubated at 37°C, and culture supernatant was harvested after 18-24 hours. IFN-γ responses were assessed by the ichroma™ IGRA-TB cartridge and the QFT-GIT IFN-γ enzyme-linked immunosorbent assay. Three act...
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Hur YG, Hong JY, Choi DH, Kim A, Park SY, Kwon M, Kang K, Lee JM, Dockrell HM, Lee Y, Joo H, Cho SN Tags: Yonsei Med J Source Type: research

Knockdown of LncRNA H19 Relieves LPS-Induced Damage by Modulating miR-130a in Osteoarthritis.
CONCLUSION: LncRNA H19 aggravated the injury of LPS-induced C28/I2 cells by sponging miR-130a, hinting a novel regulatory mechanism and a potential therapeutic target for OA. PMID: 30900425 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Hu Y, Li S, Zou Y Tags: Yonsei Med J Source Type: research

Subcutaneous Immunotherapy in Patients with Fagales Pollen-Induced Oral Allergy Syndrome.
This study aimed to investigate whether subcutaneous immunotherapy (SCIT) with Fagales pollen-containing extracts can improve the clinical symptoms of OAS in Korea. In total, 56 OAS patients were included: 19 subjects treated with SCIT, which included Fagales pollen extracts, and 37 not treated with immunotherapy (IT). We reviewed the patients' medical records and administered a telephone questionnaire at one point to assess baseline OAS features and changes in the patients' OAS and allergic rhinoconjunctivitis (ARC) symptoms after treatment. Only 12 patients who received SCIT and 15 patients that did not receive SCIT coul...
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Kong N, Kim S, Lee SC, Park KH, Lee JH, Park JW Tags: Yonsei Med J Source Type: research

Genitopatellar Syndrome Secondary to De Novo KAT6B Mutation: The First Genetically Confirmed Case in South Korea.
We report the case of a female infant diagnosed with GPS to a KAT6B gene mutation, which was identified using whole exome sequencing. PMID: 30900427 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Kim BR, Han JH, Shin JE, Park MS, Park KI, Namgung R, Lee HJ, Lee JS, Eun HS Tags: Yonsei Med J Source Type: research

Genetic Data Are a Prerequisite for Interpreting Clinical and Muscle Biopsy Findings in MELAS.
PMID: 30900428 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Finsterer J Tags: Yonsei Med J Source Type: research

The Author Reply: Genetic Data Are a Prerequisite for Interpreting Clinical and Muscle Biopsy Findings in MELAS.
PMID: 30900429 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Authors: Lee YM Tags: Yonsei Med J Source Type: research

Erratum to "MicroRNA-370 Regulates Cellepithelial-Mesenchymal Transition, Migration, Invasion, and Prognosis of Hepatocellular Carcinoma by Targeting GUCD1" by He Y and He X (Yonsei Med J 2019;60:267-276.).
Erratum to "MicroRNA-370 Regulates Cellepithelial-Mesenchymal Transition, Migration, Invasion, and Prognosis of Hepatocellular Carcinoma by Targeting GUCD1" by He Y and He X (Yonsei Med J 2019;60:267-276.). Yonsei Med J. 2019 Apr;60(4):402 Authors: Abstract This corrects the article on p. 267 in vol. 60, PMID: 30799589. PMID: 30900430 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 24, 2019 Category: Universities & Medical Training Tags: Yonsei Med J Source Type: research

Ten Thousand Consecutive Gastrectomies for Gastric Cancer: Perspectives of a Master Surgeon.
This article reviews his contribution and long history of service in the field of gastric cancer. The perspectives of this master surgeon, based on his profound experience and insights, will outline directions for integrative multidisciplinary health care and how can surgeons prepare for the future. PMID: 30799586 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Choi YY, Cho M, Kwon IG, Son T, Kim HI, Choi SH, Cheong JH, Hyung WJ Tags: Yonsei Med J Source Type: research

Current State of Research on the Risk of Morbidity and Mortality Associated with Air Pollution in Korea.
CONCLUSION: There have been many epidemiologic studies in Korea regarding air pollution and health. However, the present review shows that additional studies, especially cohort and experimental studies, are needed to provide more robust and accurate evidence that can be used to promote evidence-based policymaking. PMID: 30799587 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Bae S, Kwon HJ Tags: Yonsei Med J Source Type: research

Trends in Prostate Cancer Prevalence and Radical Prostatectomy Rate according to Age Structural Changes in South Korea between 2005 and 2015.
CONCLUSION: Age structural change can affect the decreasing trend in Pca prevalence and RP rate in South Korea. Future studies are needed to validate this result. PMID: 30799588 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Lee HY, Park S, Doo SW, Yang WJ, Song YS, Kim JH Tags: Yonsei Med J Source Type: research

MicroRNA-370 Regulates Cellepithelial-Mesenchymal Transition, Migration, Invasion, and Prognosis of Hepatocellular Carcinoma by Targeting GUCD1.
CONCLUSION: Taken together, our study confirmed that miR-370 suppressed HCC cell metastasis and EMT via regulating GUCD1. Accordingly, the miR-370/GUCD1 axis may potentially acts as attractive therapeutic targets and novel biomarkers for HCC treatment. PMID: 30799589 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: He Y, He X Tags: Yonsei Med J Source Type: research

Label Adherence for Non-Vitamin K Antagonist Oral Anticoagulants in a Prospective Cohort of Asian Patients with Atrial Fibrillation.
CONCLUSION: In real-world practice, more than one-third of patients with NOAC prescriptions received an off-label reduced dose, which could result in an increased risk of stroke. Considering the high risk of stroke in these patients, on-label use of NOAC is recommended. PMID: 30799590 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Lee SR, Lee YS, Park JS, Cha MJ, Kim TH, Park J, Park JK, Lee JM, Kang KW, Shim J, Uhm JS, Kim J, Kim C, Kim JB, Park HW, Joung B, Choi EK Tags: Yonsei Med J Source Type: research

Correlation between Ovarian Reserve and Incidence of Ectopic Pregnancy after In Vitro Fertilization and Embryo Transfer.
CONCLUSION: DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR. PMID: 30799591 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Kim SW, Kim YJ, Shin JH, Kim H, Ku SY, Suh CS, Kim SH, Choi YM Tags: Yonsei Med J Source Type: research

The Impact of Perioperative Factors on Changes in Diastolic Function after Kidney Transplantation: A Retrospective Analysis.
CONCLUSION: KT is associated with improved diastolic function. Post-KT renal function was significantly related to changes in LV diastolic function. The amount of intraoperative fluid was a risk factor for worsening diastolic function after KT in patients with preexisting diastolic dysfunction. PMID: 30799592 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Kim EJ, Koo BN, Kim SY, Huh KH, Kang S, Choi YS Tags: Yonsei Med J Source Type: research

MiR-590 Inhibits Endothelial Cell Apoptosis by Inactivating the TLR4/NF- κB Pathway in Atherosclerosis.
CONCLUSION: miR-590 promoted proliferation and blocked ox-LDL-induced apoptosis in HAECs through inhibition of the TLR4/NF-κB pathway. PMID: 30799593 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Yang L, Gao C Tags: Yonsei Med J Source Type: research

A Rare Cause of Life-Threatening Ketoacidosis: Novel Compound Heterozygous OXCT1 Mutations Causing Succinyl-CoA:3-Ketoacid CoA Transferase Deficiency.
Abstract Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is a rare inborn error of ketone body utilization, characterized by episodic or permanent ketosis. SCOT deficiency is caused by mutations in the OXCT1 gene, which is mapped to 5p13 and consists of 17 exons. A 12-month-old girl presented with severe ketoacidosis and was treated with continuous renal replacement therapy. She had two previously unrecognized mild-form episodes of ketoacidosis followed by febrile illness. While high levels of ketone bodies were found in her blood and urine, other laboratory investigations, including serum glucose, were ...
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Kim YA, Kim SH, Cheon CK, Kim YM Tags: Yonsei Med J Source Type: research

Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions.
We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-old girl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx, cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. She complained of severe pain in the neck and cutaneous lesions. Initially, the development of EN was attributed to Salmonella spp infection, which was detected in stool culture. However, the patient did not respond to high-dose ampicillin/sulbactam to which the Salmon...
Source: Yonsei Medical Journal - February 28, 2019 Category: Universities & Medical Training Authors: Okada S, Ishikawa Y, Shimomura M, Sunagawa S, Hirano R, Fukunaga S, Miyake A, Okada Y, Maki T Tags: Yonsei Med J Source Type: research

Desensitization for Allergic Reactions to Chemotherapy.
Abstract Drug desensitization is procedure by which patients can be tolerized to medications that have previously induced hypersensitivity reactions. Initially used in treating hypersensitivity reactions to antibiotics, desensitization is now frequently used in the setting of allergy to chemotherapy drugs and biologics, thus widening the clinical applicability of this procedure which has been proven to be quite safe and effective in improving clinical outcomes, mainly by allowing patients to remain on preferred first-line therapy. This paper reviews the history, application, and safety studies of drug desensitizat...
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Hong DIC Tags: Yonsei Med J Source Type: research

Tumor Necrosis Factor and Regulatory T Cells.
Abstract CD4⁺CD25⁺FoxP3⁺ regulatory T (Treg) cells play major roles in the maintenance of immune homeostasis. In this review, we comprehensively describe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Treg cells and on TNF-producing Treg cells. Contradictory results have been reported for the effect of TNF on the suppressive activity of Treg cells. In patients with rheumatoid arthritis, TNF has been shown to reduce the suppressive activity of Treg cells. Meanwhile, however, TNF has also been reported to maintain the suppressive activity of Treg cells vi...
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Jung MK, Lee JS, Kwak JE, Shin EC Tags: Yonsei Med J Source Type: research

Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial.
CONCLUSION: SPC, MSI, and EBV statuses could be used in combination to predict the prognosis and responsiveness of adjuvant chemotherapy for stage II/III gastric cancer. PMID: 30666834 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Roh CK, Choi YY, Choi S, Seo WJ, Cho M, Jang E, Son T, Kim HI, Kim H, Hyung WJ, Huh YM, Noh SH, Cheong JH Tags: Yonsei Med J Source Type: research

The 7th/8th American Joint Committee on Cancer and the Modified Union for International Cancer Control Staging System for Hepatocellular Carcinoma.
CONCLUSION: mUICC seemed to be superior to the 7th/8th AJCC after analyzing the data of our surgical patients, although the geographic heterogeneity of HCC might result in differences between the staging systems. We believe that, while the three staging systems allow for the clear stratification of patients into prognostic groups, mUICC may be more appropriate in HCC. PMID: 30666835 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Kim IG, Hu XG, Wang HJ, Kim BW, Hong SY, Shen XY Tags: Yonsei Med J Source Type: research

MiR-182-5p Knockdown Targeting PTEN Inhibits Cell Proliferation and Invasion of Breast Cancer Cells.
CONCLUSION: MiR-182-5p exhaustion blocked cell proliferation and invasion by regulating PTEN expression, providing a novel therapeutic avenue for treatment of BC. PMID: 30666836 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Zhao YS, Yang WC, Xin HW, Han JX, Ma SG Tags: Yonsei Med J Source Type: research

Image Analysis of HER2 Immunohistochemical Staining of Surgical Breast Cancer Specimens.
CONCLUSION: HER2 image analysis results were similar to those obtained via the manual scoring method, indicating that the use of image analysis can reduce assessment time and effort. We suggest that image analysis-based evaluation of 1000 tumor cells in the most strongly IHC-stained area, regardless of stroma content, is sufficient for determining HER2 expression levels in breast cancer specimens. PMID: 30666837 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Yim K, Park HS, Kim DM, Lee YS, Lee A Tags: Yonsei Med J Source Type: research

MicroRNA-206 Reduces Osteosarcoma Cell Malignancy In Vitro by Targeting the PAX3-MET Axis.
CONCLUSION: miR-206 reduces OS cell malignancy in vitro by targeting PAX3 and MET gene expression. PMID: 30666838 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Zhan FB, Zhang XW, Feng SL, Cheng J, Zhang Y, Li B, Xie LZ, Deng QR Tags: Yonsei Med J Source Type: research

Prognostic Value of Lymphovascular Invasion in Node-Negative Upper Urinary Tract Urothelial Carcinoma Patients Undergoing Radical Nephroureterectomy.
This study aimed to evaluate the prognostic impact of lymphovascular invasion (LVI) in patients treated with radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We collected data from 180 patients who were treated with RNU from 2005 to 2013 at our institution. The Kaplan-Meier method with log-rank test and Cox proportional hazards regression models were used for univariate and multivariate analyses. RESULTS: LVI was present in 28 patients (15.6%), which was associated with higher pathological tumor stage (p
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Liu W, Zhou Z, Dong D, Sun L, Zhang G Tags: Yonsei Med J Source Type: research

Silencing the PIK3CA Gene Enhances the Sensitivity of Childhood Leukemia Cells to Chemotherapy Drugs by Suppressing the Phosphorylation of Akt.
This study aimed to investigate the effects of PIK3CA on the sensitivity of acute B lymphocytic leukemia cells (Nalm-6 cells) to chemotherapy drugs. MATERIALS AND METHODS: Children's normal B lymphocytes and Nalm-6 cells were cultured. Nalm-6 cells were transfected with PIK3CA siRNA (siPIK3CA group) or its negative control (PIK3CA-Control group). Normal Nalm-6 cells were named Mock group. Nalm-6 cells transfected by PIK3CA siRNA were treated with Akt inhibitor (siPIK3CA+Akti-1/2 group). mRNA and protein expression was detected by qRT-PCR and Western blot. Proliferation and sensitivity to chemotherapeutic drugs was det...
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Liang X, Xin X, Qi D, Fu C, Ding M Tags: Yonsei Med J Source Type: research

Machine Learning for the Prediction of New-Onset Diabetes Mellitus during 5-Year Follow-up in Non-Diabetic Patients with Cardiovascular Risks.
In this study, a total of available 8454 patients who had no history of diabetes and were treated at the cardiovascular center of Korea University Guro Hospital were enrolled. All subjects completed 5 years of follow up. The prevalence of T2DM during follow up was 4.78% (404/8454). A total of 28 variables were extracted from the EMRs. In order to verify the cross-validation test according to the prediction model, logistic regression (LR), linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), and K-nearest neighbor (KNN) algorithm models were generated. The LR model was considered as the existing statis...
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Choi BG, Rha SW, Kim SW, Kang JH, Park JY, Noh YK Tags: Yonsei Med J Source Type: research

Signal Detection for Cardiovascular Adverse Events of DPP-4 Inhibitors Using the Korea Adverse Event Reporting System Database, 2008-2016.
CONCLUSION: Analysis of spontaneous ADR reports data on the use of DPP-4 inhibitors could not showed the association between DPP-4 inhibitors and cardiovascular AEs, due to a small number of cardiovascular AEs reports. PMID: 30666842 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Yi H, Lee JH, Shin JY Tags: Yonsei Med J Source Type: research

Analysis of Individual Case Safety Reports of Severe Cutaneous Adverse Reactions in Korea.
CONCLUSION: The number of SCAR ICSRs has increased rapidly with recent active pharmacovigilance programs in Korea. Allopurinol and antiepileptics are the most common individual and categorical causative agents, respectively. PMID: 30666843 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Kang MG, Sohn KH, Kang DY, Park HK, Yang MS, Lee JY, Kang HR Tags: Yonsei Med J Source Type: research

Bacterial and Viral Identification Rate in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Korea.
Abstract PURPOSE: The most common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is respiratory infection. Most studies of bacterial or viral cause in AECOPD have been conducted in Western countries. We investigated bacterial and viral identification rates in AECOPD in Korea. MATERIALS AND METHODS: We reviewed and analyzed medical records of 736 cases of AECOPD at the Korea University Guro Hospital. We analyzed bacterial and viral identification rates and classified infections according to epidemiological factors, such as Global Initiative for Chronic Obstructive Lung Disease st...
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Choi J, Oh JY, Lee YS, Hur GY, Lee SY, Shim JJ, Kang KH, Min KH Tags: Yonsei Med J Source Type: research

The Risk of Malignancy in Korean Patients with Rheumatoid Arthritis.
CONCLUSION: The overall cancer incidence was increased in Korean men and women with RA. Increased risk of specific malignancy differed according to sex. PMID: 30666845 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Lee H Tags: Yonsei Med J Source Type: research

Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions.
PMID: 30666846 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Finsterer J Tags: Yonsei Med J Source Type: research

The Author Reply: Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions.
PMID: 30666847 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Lee YM Tags: Yonsei Med J Source Type: research

Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes.
Abstract For the past three decades, a large number of genetic studies have been performed to examine genetic variants associated with asthma and its subtypes in hopes of gaining better understanding of the mechanisms underlying disease pathology and to identify genetic biomarkers predictive of disease outcomes. Various methods have been used to achieve these objectives, including linkage analysis, candidate gene polymorphism analysis, and genome-wide association studies (GWAS); however, the degree to which genetic variants contribute to asthma pathogenesis has proven to be much less significant than originally ex...
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Park JS, Son JH, Park CS, Chang HS Tags: Yonsei Med J Source Type: research

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review.
Abstract Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of systemic necrotising vasculitides, which often involve small vessels, and which lead to few or no immune deposits in affected organs. According to clinical manifestations and pathological features, AAV is classified into three variants: microscopic polyangiitis, granulomatosis with polyangiitis (GPA), and eosinophilic GPA. The American College of Rheumatology 1990 criteria contributed to the classification of AAV, although currently the algorithm suggested by the European Medicines Agency in 2007 and the Chapel Hill Consensus Co...
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Choi CB, Park YB, Lee SW Tags: Yonsei Med J Source Type: research

MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3.
CONCLUSION: miR-506 enhanced NK cell cytotoxicity against HCC cells by targeting STAT3, suggesting that modulating miR-506 expression maybe a promising approach for enhancing NK cell-based antitumor therapies. PMID: 30554487 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Su Z, Ye X, Shang L Tags: Yonsei Med J Source Type: research

Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy.
Abstract PURPOSE: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer (BC) patients undergoing epirubicin/cyclophosphamide-docetaxel (EC-D) adjuvant chemotherapy. MATERIALS AND METHODS: 427 BC patients who had underwent surgery were consecutively enrolled in this prospective cohort study. All patients were scheduled to receive EC-D adjuvant chemotherapy regimen, and they were divided into UGT2B7 -161 CC (n=141), UGT2B7 -161 CT (n=196), and UGT2B...
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Li H, Hu B, Guo Z, Jiang X, Su X, Zhang X Tags: Yonsei Med J Source Type: research

Up-Regulation of MiR-1915 Inhibits Proliferation, Invasion, and Migration of Helicobacter pylori-Infected Gastric Cancer Cells via Targeting RAGE.
CONCLUSION: MiR-1915 exerted tumor-suppressive effects on cellular proliferation, invasion, and migration of HP-infected GC cells via targeting RAGE, which provided an innovative target candidate for treatment of HP-infected GC. PMID: 30554489 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Xu XC, Zhang WB, Li CX, Gao H, Pei Q, Cao BW, He TH Tags: Yonsei Med J Source Type: research

Left Ventricular End-Systolic Volume Can Predict 1-Year Hierarchical Clinical Composite End Point in Patients with Cardiac Resynchronization Therapy.
This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP). MATERIALS AND METHODS: We included 120 patients (age, 66.1±12.6 years; men, 54.2%) who underwent CRT implantation for heart failure (HF). Echocardiography was performed before and at 3, 6, and 12 months after CRT implantation. The 1-year HCCEP included all-cause mortality, hospitalization for HF, and New York Heart Association functional class for 12 months. CRT response criteria were decre...
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Uhm JS, Oh J, Cho IJ, Park M, Kim IS, Jin MN, Bae HJ, Yu HT, Kim TH, Pak HN, Lee MH, Joung B, Kang SM Tags: Yonsei Med J Source Type: research

Characterization of Flow Efficiency, Pulsatility, and Respiratory Variability in Different Types of Fontan Circuits Using Quantitative Parameters.
This study was undertaken to investigate hemodynamic characteristics in different types of Fontan circulation by quantification of blood flow with the combined influence of cardiac and respiratory cycles. MATERIALS AND METHODS: Thirty-five patients [10 atriopulmonary connections (APC), 13 lateral tunnels (LT), and 12 extracardiac conduits (ECC)] were evaluated, and parameters were measured in the superior vena cava, inferior vena cava (IVC), hepatic vein (HV), baffles, conduits, and left and right pulmonary artery. Pulsatility index (PIx), respiratory variability index (RVI), net antegrade flow integral (NAFI), and in...
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Ha KS, Choi JY, Jung SY, Park HK Tags: Yonsei Med J Source Type: research

Antithrombotic Medication and the Risk of Vitreous Hemorrhage in Atrial Fibrillation: Korean National Health Insurance Service National Cohort.
CONCLUSION: Dual antiplatelet or triple therapy increased the risk of VH significantly, compared to warfarin monotherapy. Considering the low efficacy of preventing ischemic stroke and high risk of bleeding, dual or triple therapy using warfarin and antiplatelet agents should be avoided to prevent VH in AF patients. PMID: 30554492 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Kim KE, Yang PS, Jang E, Kim S, Joung B Tags: Yonsei Med J Source Type: research

Quality of Bowel Preparation for Colonoscopy in Patients with a History of Abdomino-Pelvic Surgery: Retrospective Cohort Study.
CONCLUSION: Only gastric/small intestinal surgery was a potential risk factor for poor bowel preparation. Further research on patients with a history of gastric/small intestinal surgery to determine appropriate methods for adequate bowel preparation is mandatory. PMID: 30554493 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 18, 2018 Category: Universities & Medical Training Authors: Kim B, Kim BC, Kim J, Oh HJ, Ryu KH, Park BJ, Sohn DK, Hong CW, Han KS Tags: Yonsei Med J Source Type: research