SARS-CoV-2 Variants of Concern
Yonsei Med J. 2021 Nov;62(11):961-968. doi: 10.3349/ymj.2021.62.11.961.ABSTRACTSince the COVID-19 pandemic first began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has continuously evolved with many variants emerging across the world. These variants are categorized as the variant of interest (VOI), variant of concern (VOC), and variant under monitoring (VUM). As of September 15, 2021, there are four SARS-CoV-2 lineages designated as the VOC (alpha, beta, gamma, and delta variants). VOCs have increased transmissibility compared to the original virus, and have the potential for inc...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jun Yong Choi Davey M Smith Source Type: research

In Vitro Models Mimicking Immune Response in the Skin
Yonsei Med J. 2021 Nov;62(11):969-980. doi: 10.3349/ymj.2021.62.11.969.ABSTRACTThe skin is the first line of defense of our body, and it is composed of the epidermis and dermis with diverse immune cells. Various in vitro models have been investigated to recapitulate the immunological functions of the skin and to model inflammatory skin diseases. The simplest model is a two-dimensional (2D) co-culture system, which helps understand the direct and indirect cell-to-cell interactions between immune and structural cells; however, it has limitations when observing three-dimensional (3D) interactions or reproducing skin barriers....
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Sujin Moon Dong Hyun Kim Jung U Shin Source Type: research

Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease
CONCLUSION: LLL was higher in women, but there was no difference in TVF between women and men. Based on multivariable analysis, the women sex was an independent predictor of higher LLL (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).PMID:34672131 | DOI:10.3349/ymj.2021.62.11.981 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Liu Kun Eun-Seok Shin Eun Jung Jun Youngjune Bhak Scot Garg Tae-Hyun Kim Chang-Bae Sohn Byung Joo Choi Lin Hui Song Lin Yuan Wang Zhi Jiang Hao Shi Zhentao Tang Qiang Source Type: research

Transcatheter Aortic Valve Replacement with Minimal Contrast Dye in Patients with Renal Insufficiency
Yonsei Med J. 2021 Nov;62(11):990-996. doi: 10.3349/ymj.2021.62.11.990.ABSTRACTPURPOSE: Concerns have been consistently raised in regards to the considerable amount of contrast dye used during transcatheter aortic valve replacement (TAVR) in patients with renal insufficiency. In the present study, we introduced minimal contrast TAVR and compared its 30-day clinical outcomes with conventional TAVR.MATERIALS AND METHODS: We retrospectively investigated 369 patients who underwent TAVR between July 2011 and April 2020 in our institute. Among them, 93 patients with severe aortic stenosis and renal insufficiency (estimated glome...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jah Yeon Choi Geu-Ru Hong Sung-Jin Hong Chi Young Shim Chul-Min Ahn Jung-Sun Kim Byeong-Keuk Kim Young-Guk Ko Donghoon Choi Yangsoo Jang Myeong-Ki Hong Source Type: research

Medications and the Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Use of the Landmark Method
CONCLUSION: In patients with inflammatory bowel disease, the preventive effect of drug exposure on colorectal cancer varies depending on the application of the landmark method. Hence, the possibility of immortal time bias should be considered.PMID:34672133 | DOI:10.3349/ymj.2021.62.11.997 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yoon Young Choi Jung Kuk Lee Hyun-Soo Kim Dong Wook Kim Hee Man Kim Dae Ryong Kang Source Type: research

Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer
CONCLUSION: Expression of MUC6 was regulated by promotor methylation. This methylation of the MUC6 promoter may lead to significant downregulation of MUC6 in GC and promote the progression of GC.PMID:34672134 | DOI:10.3349/ymj.2021.62.11.1005 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Ding Shi Xiao-Xia Xi Source Type: research

Serum Clusterin Level Could Reflect the Current Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
CONCLUSION: Serum clusterin levels could reflect the current disease activity in patients with AAV.PMID:34672135 | DOI:10.3349/ymj.2021.62.11.1016 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Taejun Yoon Sung Soo Ahn Jung Yoon Pyo Jason Jungsik Song Yong-Beom Park Sang-Won Lee Source Type: research

Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
CONCLUSION: IL-37 inhibits CpG-ODN-mediated inflammatory responses through regulation of a TRAF6-NF-κB pathway in human macrophages.PMID:34672136 | DOI:10.3349/ymj.2021.62.11.1023 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seong-Kyu Kim Jung-Yoon Choe Ki-Yeun Park Source Type: research

Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration
This study aimed to characterize thrombus formation in a mouse model.MATERIALS AND METHODS: We investigated thrombus formation and stability using various FeCl3 concentrations (10%, 20%, 30%, 40%, and 50%, w/v) in carotid arteries of the Institute of Cancer Research (ICR) and C57BL/6N mice using the FeCl3-induced thrombosis model. We also investigated thrombus histopathology using immunohistochemistry and electron microscopy.RESULTS: Higher FeCl3 concentrations induced dose-dependent, faster, larger, and more stable thrombus formation in both strains of mice. However, the ICR mice showed better dose-responses in thrombus f...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yeseul Shim Il Kwon Youngseon Park Heow Won Lee Jayoung Kim Young Dae Kim Hyo Suk Nam Sungha Park Ji Hoe Heo Source Type: research

Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors
This study aimed to enhance the efficacy of near-infrared (NIR) fluorescence imaging by overcoming the shortcomings of ICG using a nano-drug delivery system and improve target specificity in cervical cancer.MATERIALS AND METHODS: ICG and poly(lactic-co-glycolic acid) (PLGA) conjugated with polyethylenimine (PEI) were assembled to enhance stability. Hyaluronic acid (HA) was coated on PEI-PLGA-ICG nanoparticles to target CD44-positive cancer cells. The manufactured HA-ICG-PLGA nanoparticles (HINPs) were evaluated in vitro and in vivo on cervical cancer cells (SiHa; CD44+) and human dermal cells (ccd986sk; CD44-), respectivel...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seonmin Choi San-Hui Lee Sanghyo Park Sun Hwa Park Chaewon Park Jaehong Key Source Type: research

A Deep Learning Model with High Standalone Performance for Diagnosis of Unruptured Intracranial Aneurysm
CONCLUSION: The present deep learning model for automated detection of unruptured intracranial aneurysms on TOF MRA achieved the target diagnostic performance comparable to that of human radiologists. With high standalone performance, this model may be useful for accurate and efficient diagnosis of intracranial aneurysm.PMID:34672139 | DOI:10.3349/ymj.2021.62.11.1052 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Bio Joo Hyun Seok Choi Sung Soo Ahn Jihoon Cha So Yeon Won Beomseok Sohn Hwiyoung Kim Kyunghwa Han Hwa Pyung Kim Jong Mun Choi Sang Min Lee Tae Gyu Kim Seung-Koo Lee Source Type: research

Developing a Dementia Platform Databank Using Multiple Existing Cohorts
This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts were used to develop this pilot platform: 1) Clinical Research Center for Dementia of South Korea (CREDOS), 2) Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease (K-BASE), 3) Environmental Pollution-induced Neurological Effects (EPINEF) study, and 4) a prospective registry in Dementia Platform Korea project (DPKR). A total of 29916 patients were included in the platform with 348 inte...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Minwoong Kang Bo Kyoung Cheon Min Jung Hahn Sang Won Seo Juhee Cho Soo-Yong Shin Duk L Na Jaelim Cho Seong Hye Choi Danbee Kang Source Type: research

SARS-CoV-2 Variants of Concern
Yonsei Med J. 2021 Nov;62(11):961-968. doi: 10.3349/ymj.2021.62.11.961.ABSTRACTSince the COVID-19 pandemic first began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has continuously evolved with many variants emerging across the world. These variants are categorized as the variant of interest (VOI), variant of concern (VOC), and variant under monitoring (VUM). As of September 15, 2021, there are four SARS-CoV-2 lineages designated as the VOC (alpha, beta, gamma, and delta variants). VOCs have increased transmissibility compared to the original virus, and have the potential for inc...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jun Yong Choi Davey M Smith Source Type: research

In Vitro Models Mimicking Immune Response in the Skin
Yonsei Med J. 2021 Nov;62(11):969-980. doi: 10.3349/ymj.2021.62.11.969.ABSTRACTThe skin is the first line of defense of our body, and it is composed of the epidermis and dermis with diverse immune cells. Various in vitro models have been investigated to recapitulate the immunological functions of the skin and to model inflammatory skin diseases. The simplest model is a two-dimensional (2D) co-culture system, which helps understand the direct and indirect cell-to-cell interactions between immune and structural cells; however, it has limitations when observing three-dimensional (3D) interactions or reproducing skin barriers....
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Sujin Moon Dong Hyun Kim Jung U Shin Source Type: research

Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease
CONCLUSION: LLL was higher in women, but there was no difference in TVF between women and men. Based on multivariable analysis, the women sex was an independent predictor of higher LLL (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).PMID:34672131 | DOI:10.3349/ymj.2021.62.11.981 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Liu Kun Eun-Seok Shin Eun Jung Jun Youngjune Bhak Scot Garg Tae-Hyun Kim Chang-Bae Sohn Byung Joo Choi Lin Hui Song Lin Yuan Wang Zhi Jiang Hao Shi Zhentao Tang Qiang Source Type: research

Transcatheter Aortic Valve Replacement with Minimal Contrast Dye in Patients with Renal Insufficiency
Yonsei Med J. 2021 Nov;62(11):990-996. doi: 10.3349/ymj.2021.62.11.990.ABSTRACTPURPOSE: Concerns have been consistently raised in regards to the considerable amount of contrast dye used during transcatheter aortic valve replacement (TAVR) in patients with renal insufficiency. In the present study, we introduced minimal contrast TAVR and compared its 30-day clinical outcomes with conventional TAVR.MATERIALS AND METHODS: We retrospectively investigated 369 patients who underwent TAVR between July 2011 and April 2020 in our institute. Among them, 93 patients with severe aortic stenosis and renal insufficiency (estimated glome...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jah Yeon Choi Geu-Ru Hong Sung-Jin Hong Chi Young Shim Chul-Min Ahn Jung-Sun Kim Byeong-Keuk Kim Young-Guk Ko Donghoon Choi Yangsoo Jang Myeong-Ki Hong Source Type: research

Medications and the Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Use of the Landmark Method
CONCLUSION: In patients with inflammatory bowel disease, the preventive effect of drug exposure on colorectal cancer varies depending on the application of the landmark method. Hence, the possibility of immortal time bias should be considered.PMID:34672133 | DOI:10.3349/ymj.2021.62.11.997 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yoon Young Choi Jung Kuk Lee Hyun-Soo Kim Dong Wook Kim Hee Man Kim Dae Ryong Kang Source Type: research

Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer
CONCLUSION: Expression of MUC6 was regulated by promotor methylation. This methylation of the MUC6 promoter may lead to significant downregulation of MUC6 in GC and promote the progression of GC.PMID:34672134 | DOI:10.3349/ymj.2021.62.11.1005 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Ding Shi Xiao-Xia Xi Source Type: research

Serum Clusterin Level Could Reflect the Current Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
CONCLUSION: Serum clusterin levels could reflect the current disease activity in patients with AAV.PMID:34672135 | DOI:10.3349/ymj.2021.62.11.1016 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Taejun Yoon Sung Soo Ahn Jung Yoon Pyo Jason Jungsik Song Yong-Beom Park Sang-Won Lee Source Type: research

Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
CONCLUSION: IL-37 inhibits CpG-ODN-mediated inflammatory responses through regulation of a TRAF6-NF-κB pathway in human macrophages.PMID:34672136 | DOI:10.3349/ymj.2021.62.11.1023 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seong-Kyu Kim Jung-Yoon Choe Ki-Yeun Park Source Type: research

Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration
This study aimed to characterize thrombus formation in a mouse model.MATERIALS AND METHODS: We investigated thrombus formation and stability using various FeCl3 concentrations (10%, 20%, 30%, 40%, and 50%, w/v) in carotid arteries of the Institute of Cancer Research (ICR) and C57BL/6N mice using the FeCl3-induced thrombosis model. We also investigated thrombus histopathology using immunohistochemistry and electron microscopy.RESULTS: Higher FeCl3 concentrations induced dose-dependent, faster, larger, and more stable thrombus formation in both strains of mice. However, the ICR mice showed better dose-responses in thrombus f...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yeseul Shim Il Kwon Youngseon Park Heow Won Lee Jayoung Kim Young Dae Kim Hyo Suk Nam Sungha Park Ji Hoe Heo Source Type: research

Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors
This study aimed to enhance the efficacy of near-infrared (NIR) fluorescence imaging by overcoming the shortcomings of ICG using a nano-drug delivery system and improve target specificity in cervical cancer.MATERIALS AND METHODS: ICG and poly(lactic-co-glycolic acid) (PLGA) conjugated with polyethylenimine (PEI) were assembled to enhance stability. Hyaluronic acid (HA) was coated on PEI-PLGA-ICG nanoparticles to target CD44-positive cancer cells. The manufactured HA-ICG-PLGA nanoparticles (HINPs) were evaluated in vitro and in vivo on cervical cancer cells (SiHa; CD44+) and human dermal cells (ccd986sk; CD44-), respectivel...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seonmin Choi San-Hui Lee Sanghyo Park Sun Hwa Park Chaewon Park Jaehong Key Source Type: research

A Deep Learning Model with High Standalone Performance for Diagnosis of Unruptured Intracranial Aneurysm
CONCLUSION: The present deep learning model for automated detection of unruptured intracranial aneurysms on TOF MRA achieved the target diagnostic performance comparable to that of human radiologists. With high standalone performance, this model may be useful for accurate and efficient diagnosis of intracranial aneurysm.PMID:34672139 | DOI:10.3349/ymj.2021.62.11.1052 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Bio Joo Hyun Seok Choi Sung Soo Ahn Jihoon Cha So Yeon Won Beomseok Sohn Hwiyoung Kim Kyunghwa Han Hwa Pyung Kim Jong Mun Choi Sang Min Lee Tae Gyu Kim Seung-Koo Lee Source Type: research

Developing a Dementia Platform Databank Using Multiple Existing Cohorts
This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts were used to develop this pilot platform: 1) Clinical Research Center for Dementia of South Korea (CREDOS), 2) Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease (K-BASE), 3) Environmental Pollution-induced Neurological Effects (EPINEF) study, and 4) a prospective registry in Dementia Platform Korea project (DPKR). A total of 29916 patients were included in the platform with 348 inte...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Minwoong Kang Bo Kyoung Cheon Min Jung Hahn Sang Won Seo Juhee Cho Soo-Yong Shin Duk L Na Jaelim Cho Seong Hye Choi Danbee Kang Source Type: research

SARS-CoV-2 Variants of Concern
Yonsei Med J. 2021 Nov;62(11):961-968. doi: 10.3349/ymj.2021.62.11.961.ABSTRACTSince the COVID-19 pandemic first began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has continuously evolved with many variants emerging across the world. These variants are categorized as the variant of interest (VOI), variant of concern (VOC), and variant under monitoring (VUM). As of September 15, 2021, there are four SARS-CoV-2 lineages designated as the VOC (alpha, beta, gamma, and delta variants). VOCs have increased transmissibility compared to the original virus, and have the potential for inc...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jun Yong Choi Davey M Smith Source Type: research

In Vitro Models Mimicking Immune Response in the Skin
Yonsei Med J. 2021 Nov;62(11):969-980. doi: 10.3349/ymj.2021.62.11.969.ABSTRACTThe skin is the first line of defense of our body, and it is composed of the epidermis and dermis with diverse immune cells. Various in vitro models have been investigated to recapitulate the immunological functions of the skin and to model inflammatory skin diseases. The simplest model is a two-dimensional (2D) co-culture system, which helps understand the direct and indirect cell-to-cell interactions between immune and structural cells; however, it has limitations when observing three-dimensional (3D) interactions or reproducing skin barriers....
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Sujin Moon Dong Hyun Kim Jung U Shin Source Type: research

Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease
CONCLUSION: LLL was higher in women, but there was no difference in TVF between women and men. Based on multivariable analysis, the women sex was an independent predictor of higher LLL (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).PMID:34672131 | DOI:10.3349/ymj.2021.62.11.981 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Liu Kun Eun-Seok Shin Eun Jung Jun Youngjune Bhak Scot Garg Tae-Hyun Kim Chang-Bae Sohn Byung Joo Choi Lin Hui Song Lin Yuan Wang Zhi Jiang Hao Shi Zhentao Tang Qiang Source Type: research

Transcatheter Aortic Valve Replacement with Minimal Contrast Dye in Patients with Renal Insufficiency
Yonsei Med J. 2021 Nov;62(11):990-996. doi: 10.3349/ymj.2021.62.11.990.ABSTRACTPURPOSE: Concerns have been consistently raised in regards to the considerable amount of contrast dye used during transcatheter aortic valve replacement (TAVR) in patients with renal insufficiency. In the present study, we introduced minimal contrast TAVR and compared its 30-day clinical outcomes with conventional TAVR.MATERIALS AND METHODS: We retrospectively investigated 369 patients who underwent TAVR between July 2011 and April 2020 in our institute. Among them, 93 patients with severe aortic stenosis and renal insufficiency (estimated glome...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jah Yeon Choi Geu-Ru Hong Sung-Jin Hong Chi Young Shim Chul-Min Ahn Jung-Sun Kim Byeong-Keuk Kim Young-Guk Ko Donghoon Choi Yangsoo Jang Myeong-Ki Hong Source Type: research

Medications and the Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Use of the Landmark Method
CONCLUSION: In patients with inflammatory bowel disease, the preventive effect of drug exposure on colorectal cancer varies depending on the application of the landmark method. Hence, the possibility of immortal time bias should be considered.PMID:34672133 | DOI:10.3349/ymj.2021.62.11.997 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yoon Young Choi Jung Kuk Lee Hyun-Soo Kim Dong Wook Kim Hee Man Kim Dae Ryong Kang Source Type: research

Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer
CONCLUSION: Expression of MUC6 was regulated by promotor methylation. This methylation of the MUC6 promoter may lead to significant downregulation of MUC6 in GC and promote the progression of GC.PMID:34672134 | DOI:10.3349/ymj.2021.62.11.1005 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Ding Shi Xiao-Xia Xi Source Type: research

Serum Clusterin Level Could Reflect the Current Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
CONCLUSION: Serum clusterin levels could reflect the current disease activity in patients with AAV.PMID:34672135 | DOI:10.3349/ymj.2021.62.11.1016 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Taejun Yoon Sung Soo Ahn Jung Yoon Pyo Jason Jungsik Song Yong-Beom Park Sang-Won Lee Source Type: research

Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
CONCLUSION: IL-37 inhibits CpG-ODN-mediated inflammatory responses through regulation of a TRAF6-NF-κB pathway in human macrophages.PMID:34672136 | DOI:10.3349/ymj.2021.62.11.1023 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seong-Kyu Kim Jung-Yoon Choe Ki-Yeun Park Source Type: research

Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration
This study aimed to characterize thrombus formation in a mouse model.MATERIALS AND METHODS: We investigated thrombus formation and stability using various FeCl3 concentrations (10%, 20%, 30%, 40%, and 50%, w/v) in carotid arteries of the Institute of Cancer Research (ICR) and C57BL/6N mice using the FeCl3-induced thrombosis model. We also investigated thrombus histopathology using immunohistochemistry and electron microscopy.RESULTS: Higher FeCl3 concentrations induced dose-dependent, faster, larger, and more stable thrombus formation in both strains of mice. However, the ICR mice showed better dose-responses in thrombus f...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yeseul Shim Il Kwon Youngseon Park Heow Won Lee Jayoung Kim Young Dae Kim Hyo Suk Nam Sungha Park Ji Hoe Heo Source Type: research

Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors
This study aimed to enhance the efficacy of near-infrared (NIR) fluorescence imaging by overcoming the shortcomings of ICG using a nano-drug delivery system and improve target specificity in cervical cancer.MATERIALS AND METHODS: ICG and poly(lactic-co-glycolic acid) (PLGA) conjugated with polyethylenimine (PEI) were assembled to enhance stability. Hyaluronic acid (HA) was coated on PEI-PLGA-ICG nanoparticles to target CD44-positive cancer cells. The manufactured HA-ICG-PLGA nanoparticles (HINPs) were evaluated in vitro and in vivo on cervical cancer cells (SiHa; CD44+) and human dermal cells (ccd986sk; CD44-), respectivel...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seonmin Choi San-Hui Lee Sanghyo Park Sun Hwa Park Chaewon Park Jaehong Key Source Type: research

A Deep Learning Model with High Standalone Performance for Diagnosis of Unruptured Intracranial Aneurysm
CONCLUSION: The present deep learning model for automated detection of unruptured intracranial aneurysms on TOF MRA achieved the target diagnostic performance comparable to that of human radiologists. With high standalone performance, this model may be useful for accurate and efficient diagnosis of intracranial aneurysm.PMID:34672139 | DOI:10.3349/ymj.2021.62.11.1052 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Bio Joo Hyun Seok Choi Sung Soo Ahn Jihoon Cha So Yeon Won Beomseok Sohn Hwiyoung Kim Kyunghwa Han Hwa Pyung Kim Jong Mun Choi Sang Min Lee Tae Gyu Kim Seung-Koo Lee Source Type: research

Developing a Dementia Platform Databank Using Multiple Existing Cohorts
This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts were used to develop this pilot platform: 1) Clinical Research Center for Dementia of South Korea (CREDOS), 2) Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease (K-BASE), 3) Environmental Pollution-induced Neurological Effects (EPINEF) study, and 4) a prospective registry in Dementia Platform Korea project (DPKR). A total of 29916 patients were included in the platform with 348 inte...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Minwoong Kang Bo Kyoung Cheon Min Jung Hahn Sang Won Seo Juhee Cho Soo-Yong Shin Duk L Na Jaelim Cho Seong Hye Choi Danbee Kang Source Type: research

SARS-CoV-2 Variants of Concern
Yonsei Med J. 2021 Nov;62(11):961-968. doi: 10.3349/ymj.2021.62.11.961.ABSTRACTSince the COVID-19 pandemic first began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has continuously evolved with many variants emerging across the world. These variants are categorized as the variant of interest (VOI), variant of concern (VOC), and variant under monitoring (VUM). As of September 15, 2021, there are four SARS-CoV-2 lineages designated as the VOC (alpha, beta, gamma, and delta variants). VOCs have increased transmissibility compared to the original virus, and have the potential for inc...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jun Yong Choi Davey M Smith Source Type: research

In Vitro Models Mimicking Immune Response in the Skin
Yonsei Med J. 2021 Nov;62(11):969-980. doi: 10.3349/ymj.2021.62.11.969.ABSTRACTThe skin is the first line of defense of our body, and it is composed of the epidermis and dermis with diverse immune cells. Various in vitro models have been investigated to recapitulate the immunological functions of the skin and to model inflammatory skin diseases. The simplest model is a two-dimensional (2D) co-culture system, which helps understand the direct and indirect cell-to-cell interactions between immune and structural cells; however, it has limitations when observing three-dimensional (3D) interactions or reproducing skin barriers....
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Sujin Moon Dong Hyun Kim Jung U Shin Source Type: research

Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease
CONCLUSION: LLL was higher in women, but there was no difference in TVF between women and men. Based on multivariable analysis, the women sex was an independent predictor of higher LLL (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).PMID:34672131 | DOI:10.3349/ymj.2021.62.11.981 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Liu Kun Eun-Seok Shin Eun Jung Jun Youngjune Bhak Scot Garg Tae-Hyun Kim Chang-Bae Sohn Byung Joo Choi Lin Hui Song Lin Yuan Wang Zhi Jiang Hao Shi Zhentao Tang Qiang Source Type: research

Transcatheter Aortic Valve Replacement with Minimal Contrast Dye in Patients with Renal Insufficiency
Yonsei Med J. 2021 Nov;62(11):990-996. doi: 10.3349/ymj.2021.62.11.990.ABSTRACTPURPOSE: Concerns have been consistently raised in regards to the considerable amount of contrast dye used during transcatheter aortic valve replacement (TAVR) in patients with renal insufficiency. In the present study, we introduced minimal contrast TAVR and compared its 30-day clinical outcomes with conventional TAVR.MATERIALS AND METHODS: We retrospectively investigated 369 patients who underwent TAVR between July 2011 and April 2020 in our institute. Among them, 93 patients with severe aortic stenosis and renal insufficiency (estimated glome...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Jah Yeon Choi Geu-Ru Hong Sung-Jin Hong Chi Young Shim Chul-Min Ahn Jung-Sun Kim Byeong-Keuk Kim Young-Guk Ko Donghoon Choi Yangsoo Jang Myeong-Ki Hong Source Type: research

Medications and the Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Use of the Landmark Method
CONCLUSION: In patients with inflammatory bowel disease, the preventive effect of drug exposure on colorectal cancer varies depending on the application of the landmark method. Hence, the possibility of immortal time bias should be considered.PMID:34672133 | DOI:10.3349/ymj.2021.62.11.997 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yoon Young Choi Jung Kuk Lee Hyun-Soo Kim Dong Wook Kim Hee Man Kim Dae Ryong Kang Source Type: research

Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer
CONCLUSION: Expression of MUC6 was regulated by promotor methylation. This methylation of the MUC6 promoter may lead to significant downregulation of MUC6 in GC and promote the progression of GC.PMID:34672134 | DOI:10.3349/ymj.2021.62.11.1005 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Ding Shi Xiao-Xia Xi Source Type: research

Serum Clusterin Level Could Reflect the Current Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
CONCLUSION: Serum clusterin levels could reflect the current disease activity in patients with AAV.PMID:34672135 | DOI:10.3349/ymj.2021.62.11.1016 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Taejun Yoon Sung Soo Ahn Jung Yoon Pyo Jason Jungsik Song Yong-Beom Park Sang-Won Lee Source Type: research

Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
CONCLUSION: IL-37 inhibits CpG-ODN-mediated inflammatory responses through regulation of a TRAF6-NF-κB pathway in human macrophages.PMID:34672136 | DOI:10.3349/ymj.2021.62.11.1023 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seong-Kyu Kim Jung-Yoon Choe Ki-Yeun Park Source Type: research

Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration
This study aimed to characterize thrombus formation in a mouse model.MATERIALS AND METHODS: We investigated thrombus formation and stability using various FeCl3 concentrations (10%, 20%, 30%, 40%, and 50%, w/v) in carotid arteries of the Institute of Cancer Research (ICR) and C57BL/6N mice using the FeCl3-induced thrombosis model. We also investigated thrombus histopathology using immunohistochemistry and electron microscopy.RESULTS: Higher FeCl3 concentrations induced dose-dependent, faster, larger, and more stable thrombus formation in both strains of mice. However, the ICR mice showed better dose-responses in thrombus f...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Yeseul Shim Il Kwon Youngseon Park Heow Won Lee Jayoung Kim Young Dae Kim Hyo Suk Nam Sungha Park Ji Hoe Heo Source Type: research

Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors
This study aimed to enhance the efficacy of near-infrared (NIR) fluorescence imaging by overcoming the shortcomings of ICG using a nano-drug delivery system and improve target specificity in cervical cancer.MATERIALS AND METHODS: ICG and poly(lactic-co-glycolic acid) (PLGA) conjugated with polyethylenimine (PEI) were assembled to enhance stability. Hyaluronic acid (HA) was coated on PEI-PLGA-ICG nanoparticles to target CD44-positive cancer cells. The manufactured HA-ICG-PLGA nanoparticles (HINPs) were evaluated in vitro and in vivo on cervical cancer cells (SiHa; CD44+) and human dermal cells (ccd986sk; CD44-), respectivel...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seonmin Choi San-Hui Lee Sanghyo Park Sun Hwa Park Chaewon Park Jaehong Key Source Type: research

A Deep Learning Model with High Standalone Performance for Diagnosis of Unruptured Intracranial Aneurysm
CONCLUSION: The present deep learning model for automated detection of unruptured intracranial aneurysms on TOF MRA achieved the target diagnostic performance comparable to that of human radiologists. With high standalone performance, this model may be useful for accurate and efficient diagnosis of intracranial aneurysm.PMID:34672139 | DOI:10.3349/ymj.2021.62.11.1052 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Bio Joo Hyun Seok Choi Sung Soo Ahn Jihoon Cha So Yeon Won Beomseok Sohn Hwiyoung Kim Kyunghwa Han Hwa Pyung Kim Jong Mun Choi Sang Min Lee Tae Gyu Kim Seung-Koo Lee Source Type: research

Developing a Dementia Platform Databank Using Multiple Existing Cohorts
This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts were used to develop this pilot platform: 1) Clinical Research Center for Dementia of South Korea (CREDOS), 2) Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease (K-BASE), 3) Environmental Pollution-induced Neurological Effects (EPINEF) study, and 4) a prospective registry in Dementia Platform Korea project (DPKR). A total of 29916 patients were included in the platform with 348 inte...
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Minwoong Kang Bo Kyoung Cheon Min Jung Hahn Sang Won Seo Juhee Cho Soo-Yong Shin Duk L Na Jaelim Cho Seong Hye Choi Danbee Kang Source Type: research

Centennial Commemoration of the Death of Lillias Horton Underwood
Yonsei Med J. 2021 Oct;62(10):873-876. doi: 10.3349/ymj.2021.62.10.873.NO ABSTRACTPMID:34558865 | PMC:PMC8470568 | DOI:10.3349/ymj.2021.62.10.873 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 24, 2021 Category: Universities & Medical Training Authors: Meehyun Chung Source Type: research

Clinical Implication of Hypoxic Liver Injury for Predicting Hypoxic Hepatitis and In-Hospital Mortality in ST Elevation Myocardial Infarction Patients
CONCLUSION: Among STEMI patients, HLI in the ER is a significant predictor for the development of HH and mortality during hospitalization (INTERSTELLAR ClinicalTrials.gov number, NCT02800421).PMID:34558866 | PMC:PMC8470566 | DOI:10.3349/ymj.2021.62.10.877 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - September 24, 2021 Category: Universities & Medical Training Authors: Seong Huan Choi Ho-Jun Jang Young Ju Suh Sang-Don Park Pyung Chun Oh Jeonggeun Moon Kyounghoon Lee Jon Suh WoongChol Kang Tae-Hoon Kim Sung Woo Kwon Source Type: research