Immune Cell-Mediated Autoimmune Responses in Severe Asthma
Yonsei Med J. 2024 Apr;65(4):194-201. doi: 10.3349/ymj.2023.0432.ABSTRACTSevere asthma (SA) has heterogeneous inflammatory phenotypes characterized by persistent airway inflammation (eosinophilic and/or neutrophilic inflammation) and remodeling. Various immune cells (eosinophils, neutrophils, and macrophages) become more activated and release inflammatory mediators and extracellular traps, damaging the protective barrier of airway epithelial cells and further activating other immune and structural cells. These cells play a role in autoimmune responses in asthmatic airways, where the adaptive immune system generates autoant...
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Thi Bich Tra Cao Quang Luu Quoc Jae-Hyuk Jang Hae-Sim Park Source Type: research

Evidence of Placental Villous Inflammation and Apoptosis in Third-Trimester Symptomatic SARS-CoV-2 Maternal Infection
CONCLUSION: The presence of SARS-CoV-2 spike protein as well as altered inflammatory and apoptotic processes may indicate the presence of placental disturbance in third-trimester maternal COVID-19 infection. The lack of correlation between placental disruption and maternal severity status suggests the need for more research to understand the infection process and any potential long-term impacts on all offsprings born to COVID-19-infected pregnant women.PMID:38515357 | DOI:10.3349/ymj.2023.0309 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Manggala Pasca Wardhana Kuntaman Kuntaman Budi Utomo Rozi Aditya Aryananda Salsabila Nabilah Rifdah Ifan Ali Wafa Almira Aulia Shahnaz Dahlia Ningrum Nareswari Imanadha Cininta Grace Ariani Jan Mm Van Lith Erry Gumilar Dachlan Source Type: research

Application of Data Mining Technology in the Screening for Gallbladder Stones: A Cross-Sectional Retrospective Study of Chinese Adults
CONCLUSION: The results of this study showed that MLP and J48 algorithms are effective at screening individuals for the risk of GS. The key attributes of data mining can further promote the prevention of GS through targeted community intervention, improve the outcome of GS, and reduce the burden on the medical system.PMID:38515358 | DOI:10.3349/ymj.2023.0246 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Shuang Wang Chenhui Bao Dongmei Pei Source Type: research

Effect of Dietary Habits on Alzheimer's Disease Progression
CONCLUSION: Eating a balanced diet and reducing salt intake were associated with a slower decline in dementia severity, cognition, and behavioral alterations in patients with ADD.PMID:38515359 | DOI:10.3349/ymj.2023.0119 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: So Hyun Ahn Jee Hyang Jeong Kyung Won Park Eun-Joo Kim Soo Jin Yoon Bora Yoon Jae-Won Jang Yangki Minn Seong Hye Choi Source Type: research

Physical Activity-Induced Modification of the Association of Long-Term Air Pollution Exposure with the Risk of Depression in Older Adults
CONCLUSION: We suggest that older adults who vigorously exercise outdoors may be susceptible to air pollution-related depression.PMID:38515360 | DOI:10.3349/ymj.2023.0292 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Woongbi Park Heeseon Jang Juyeon Ko Jungwoo Sohn Young Noh Sun-Young Kim Sang-Baek Koh Changsoo Kim Jaelim Cho Source Type: research

Trend in the Incidence of Severe Partial Edentulism among Adults Using the Korean National Health Insurance Service Claim Data, 2014-2018
CONCLUSION: The study showed that the incidence trend of SPE increased and decreased from 2014 to 2018. This result would be able to aid in the planning of public oral health, and may also serve as fundamental data for verifying the impact of the public oral health policies implemented.PMID:38515361 | DOI:10.3349/ymj.2023.0380 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Hyeonjeong Go Hoi-In Jung Song Vogue Ahn Jeonghoon Ahn Hosung Shin Atsuo Amano Youn-Hee Choi Source Type: research

The First Case of a Korean Patient with a Mutation-Confirmed Tumor Necrosis Factor Receptor-Associated Periodic Syndrome
Yonsei Med J. 2024 Apr;65(4):241-245. doi: 10.3349/ymj.2023.0366.ABSTRACTTumor necrosis factor receptor-associated periodic syndrome (TRAPS, OMIM: #142680) is a rare autoinflammatory disease (AID) with recurrent febrile episodes. To our knowledge, we report herein the first case of a patient with TRAPS in South Korea whose symptoms included fever, arthralgia, abdominal pain, rash, myalgia, cough, and lymphadenopathy. A pathogenic de novo mutation, c.175T>C (p.Cys59Arg), in the tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) gene, was confirmed by gene sequencing. The patient has been with tocilizumab (an...
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Seok-Jin Lee Jee Yeon Baek Ji Young Lee Ji-Man Kang Jong Gyun Ahn Source Type: research

Ssangcheon, Life of Lee Young-Choon (1903-1980)
Yonsei Med J. 2024 Apr;65(4):189-193. doi: 10.3349/ymj.2023.0445.NO ABSTRACTPMID:38515355 | DOI:10.3349/ymj.2023.0445 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Kang-Hyu Lee Joo-Min Lee Soon-Jae Yoon Chang-Seop Lee Source Type: research

Immune Cell-Mediated Autoimmune Responses in Severe Asthma
Yonsei Med J. 2024 Apr;65(4):194-201. doi: 10.3349/ymj.2023.0432.ABSTRACTSevere asthma (SA) has heterogeneous inflammatory phenotypes characterized by persistent airway inflammation (eosinophilic and/or neutrophilic inflammation) and remodeling. Various immune cells (eosinophils, neutrophils, and macrophages) become more activated and release inflammatory mediators and extracellular traps, damaging the protective barrier of airway epithelial cells and further activating other immune and structural cells. These cells play a role in autoimmune responses in asthmatic airways, where the adaptive immune system generates autoant...
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Thi Bich Tra Cao Quang Luu Quoc Jae-Hyuk Jang Hae-Sim Park Source Type: research

Evidence of Placental Villous Inflammation and Apoptosis in Third-Trimester Symptomatic SARS-CoV-2 Maternal Infection
CONCLUSION: The presence of SARS-CoV-2 spike protein as well as altered inflammatory and apoptotic processes may indicate the presence of placental disturbance in third-trimester maternal COVID-19 infection. The lack of correlation between placental disruption and maternal severity status suggests the need for more research to understand the infection process and any potential long-term impacts on all offsprings born to COVID-19-infected pregnant women.PMID:38515357 | DOI:10.3349/ymj.2023.0309 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Manggala Pasca Wardhana Kuntaman Kuntaman Budi Utomo Rozi Aditya Aryananda Salsabila Nabilah Rifdah Ifan Ali Wafa Almira Aulia Shahnaz Dahlia Ningrum Nareswari Imanadha Cininta Grace Ariani Jan Mm Van Lith Erry Gumilar Dachlan Source Type: research

Application of Data Mining Technology in the Screening for Gallbladder Stones: A Cross-Sectional Retrospective Study of Chinese Adults
CONCLUSION: The results of this study showed that MLP and J48 algorithms are effective at screening individuals for the risk of GS. The key attributes of data mining can further promote the prevention of GS through targeted community intervention, improve the outcome of GS, and reduce the burden on the medical system.PMID:38515358 | DOI:10.3349/ymj.2023.0246 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Shuang Wang Chenhui Bao Dongmei Pei Source Type: research

Effect of Dietary Habits on Alzheimer's Disease Progression
CONCLUSION: Eating a balanced diet and reducing salt intake were associated with a slower decline in dementia severity, cognition, and behavioral alterations in patients with ADD.PMID:38515359 | DOI:10.3349/ymj.2023.0119 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: So Hyun Ahn Jee Hyang Jeong Kyung Won Park Eun-Joo Kim Soo Jin Yoon Bora Yoon Jae-Won Jang Yangki Minn Seong Hye Choi Source Type: research

Physical Activity-Induced Modification of the Association of Long-Term Air Pollution Exposure with the Risk of Depression in Older Adults
CONCLUSION: We suggest that older adults who vigorously exercise outdoors may be susceptible to air pollution-related depression.PMID:38515360 | DOI:10.3349/ymj.2023.0292 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Woongbi Park Heeseon Jang Juyeon Ko Jungwoo Sohn Young Noh Sun-Young Kim Sang-Baek Koh Changsoo Kim Jaelim Cho Source Type: research

Trend in the Incidence of Severe Partial Edentulism among Adults Using the Korean National Health Insurance Service Claim Data, 2014-2018
CONCLUSION: The study showed that the incidence trend of SPE increased and decreased from 2014 to 2018. This result would be able to aid in the planning of public oral health, and may also serve as fundamental data for verifying the impact of the public oral health policies implemented.PMID:38515361 | DOI:10.3349/ymj.2023.0380 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Hyeonjeong Go Hoi-In Jung Song Vogue Ahn Jeonghoon Ahn Hosung Shin Atsuo Amano Youn-Hee Choi Source Type: research

The First Case of a Korean Patient with a Mutation-Confirmed Tumor Necrosis Factor Receptor-Associated Periodic Syndrome
Yonsei Med J. 2024 Apr;65(4):241-245. doi: 10.3349/ymj.2023.0366.ABSTRACTTumor necrosis factor receptor-associated periodic syndrome (TRAPS, OMIM: #142680) is a rare autoinflammatory disease (AID) with recurrent febrile episodes. To our knowledge, we report herein the first case of a patient with TRAPS in South Korea whose symptoms included fever, arthralgia, abdominal pain, rash, myalgia, cough, and lymphadenopathy. A pathogenic de novo mutation, c.175T>C (p.Cys59Arg), in the tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) gene, was confirmed by gene sequencing. The patient has been with tocilizumab (an...
Source: Yonsei Medical Journal - March 22, 2024 Category: Universities & Medical Training Authors: Seok-Jin Lee Jee Yeon Baek Ji Young Lee Ji-Man Kang Jong Gyun Ahn Source Type: research