Aetiology and Prognosis of Encephalitis in Korean Children: A Retrospective Single-Centre Study, 2005-2020
CONCLUSION: This large-scale study showed that autoimmune and infectious causes accounted for a significant proportion of encephalitis in Korean children. Further studies are needed to determine whether early targeted treatment following early diagnosis leads to a favourable prognosis in these populations.PMID:38288648 | PMC:PMC10827636 | DOI:10.3349/ymj.2023.0250 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Ahra Kim Minyoung Kim Jee Yeon Baek Ji Young Lee Se Hee Kim Ji-Man Kang Jong Gyun Ahn Hoon-Chul Kang Source Type: research

Retention Rates and Successful Treatment with Antiseizure Medications in Newly-Diagnosed Epilepsy Patients
CONCLUSION: Second-generation ASMs have the advantage of more successful treatment with fewer ASM regimen changes compared with first-generation drugs. Various comorbid conditions as well as age and sex should be considered when selecting ASMs.PMID:38288649 | PMC:PMC10827640 | DOI:10.3349/ymj.2022.0539 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungeun Hwang Hyungmi An Dong Woo Shin Hyang Woon Lee Source Type: research

Exploring the Safety and Efficacy of Organic Light-Emitting Diode in Skin Rejuvenation and Wound Healing
CONCLUSION: This study established comparable effectiveness between OLED and LED irradiation in upregulating collagen and growth factor expression levels while downregulating MMP levels in vitro. In the UV-irradiated animal skin model, OLED exposure post UV radiation correlated with reduced skin wrinkles and augmented dermal collagen density. Accelerated wound recovery and demonstrated safety further underscore OLEDs' potential as a future PBM modality alongside LEDs, offering promise in the realms of skin rejuvenation and wound healing.PMID:38288650 | PMC:PMC10827635 | DOI:10.3349/ymj.2023.0125 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Young In Lee Sang Gyu Lee Seoyoon Ham Inhee Jung Jangmi Suk Ju Hee Lee Source Type: research

Reaching New Heights: A Comprehensive Study of Hand Transplantations in Korea after Institutionalization of Hand Transplantation Law
CONCLUSION: Hand transplantation is a viable reconstructive option, and patients have shown positive functional and psychological outcomes. Although this study has limitations, such as the small number of patients and short follow-up period, we should focus on continued recovery of hand function, and be careful not to develop side effects from immunosuppressive drugs. Through the present study, we will continue to strive for a bright future regarding hand transplantation in Korea.PMID:38288651 | PMC:PMC10827641 | DOI:10.3349/ymj.2023.0365 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Yo Han Kim Yun Rak Choi Dong Jin Joo Woo Yeol Baek Young Chul Suh Won Taek Oh Jae Yong Cho Sang Chul Lee Sang Kyum Kim Hyang Joo Ryu Kyung Ock Jeon Won Jai Lee Jong Won Hong Source Type: research

Evaluation of the Regulatory Required Post-Authorization Safety Study for Propacetamol: Nested Case-Control and Case-Time-Control Studies
CONCLUSION: In both nested case-control and CTC analyses, propacetamol was not associated with an increased risk of anaphylaxis, thrombosis, or SJS. The findings from this study, which used routinely collected clinical data, provide reassuring real-world evidence regarding the safety of propacetamol in a nationwide population to support regulatory decision-making.PMID:38288652 | PMC:PMC10827637 | DOI:10.3349/ymj.2023.0207 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungho Bea Dongwon Yoon Han Eol Jeong Juhong Jung Seung-Mok Park Juhee Jeon Young-Min Ye Jae-Hyun Lee Ju-Young Shin Source Type: research

Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging
Yonsei Med J. 2024 Feb;65(2):55-69. doi: 10.3349/ymj.2023.0131.ABSTRACTMitochondria function as platforms for bioenergetics, nutrient metabolism, intracellular signaling, innate immunity regulators, and modulators of stem cell activity. Thus, the decline in mitochondrial functions causes or correlates with diabetes mellitus and many aging-related diseases. Upon stress or damage, the mitochondria elicit a series of adaptive responses to overcome stress and restore their structural integrity and functional homeostasis. These adaptive responses to low-level or transient mitochondrial stress promote health and resilience to up...
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Se Hee Min Gil Myoung Kang Jae Woo Park Min-Seon Kim Source Type: research

Alterations in Plasma Cytokine Levels in Korean Children with Autism Spectrum Disorder
CONCLUSION: We confirmed that Korean children with ASD showed altered immune function and unique cytokine expression patterns distinct from TDC.PMID:38288647 | PMC:PMC10827638 | DOI:10.3349/ymj.2023.0362 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Songjoo Shim Sungji Ha Juli Choi Ho-Keun Kwon Keun-Ah Cheon Source Type: research

Aetiology and Prognosis of Encephalitis in Korean Children: A Retrospective Single-Centre Study, 2005-2020
CONCLUSION: This large-scale study showed that autoimmune and infectious causes accounted for a significant proportion of encephalitis in Korean children. Further studies are needed to determine whether early targeted treatment following early diagnosis leads to a favourable prognosis in these populations.PMID:38288648 | PMC:PMC10827636 | DOI:10.3349/ymj.2023.0250 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Ahra Kim Minyoung Kim Jee Yeon Baek Ji Young Lee Se Hee Kim Ji-Man Kang Jong Gyun Ahn Hoon-Chul Kang Source Type: research

Retention Rates and Successful Treatment with Antiseizure Medications in Newly-Diagnosed Epilepsy Patients
CONCLUSION: Second-generation ASMs have the advantage of more successful treatment with fewer ASM regimen changes compared with first-generation drugs. Various comorbid conditions as well as age and sex should be considered when selecting ASMs.PMID:38288649 | PMC:PMC10827640 | DOI:10.3349/ymj.2022.0539 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungeun Hwang Hyungmi An Dong Woo Shin Hyang Woon Lee Source Type: research

Exploring the Safety and Efficacy of Organic Light-Emitting Diode in Skin Rejuvenation and Wound Healing
CONCLUSION: This study established comparable effectiveness between OLED and LED irradiation in upregulating collagen and growth factor expression levels while downregulating MMP levels in vitro. In the UV-irradiated animal skin model, OLED exposure post UV radiation correlated with reduced skin wrinkles and augmented dermal collagen density. Accelerated wound recovery and demonstrated safety further underscore OLEDs' potential as a future PBM modality alongside LEDs, offering promise in the realms of skin rejuvenation and wound healing.PMID:38288650 | PMC:PMC10827635 | DOI:10.3349/ymj.2023.0125 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Young In Lee Sang Gyu Lee Seoyoon Ham Inhee Jung Jangmi Suk Ju Hee Lee Source Type: research

Reaching New Heights: A Comprehensive Study of Hand Transplantations in Korea after Institutionalization of Hand Transplantation Law
CONCLUSION: Hand transplantation is a viable reconstructive option, and patients have shown positive functional and psychological outcomes. Although this study has limitations, such as the small number of patients and short follow-up period, we should focus on continued recovery of hand function, and be careful not to develop side effects from immunosuppressive drugs. Through the present study, we will continue to strive for a bright future regarding hand transplantation in Korea.PMID:38288651 | PMC:PMC10827641 | DOI:10.3349/ymj.2023.0365 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Yo Han Kim Yun Rak Choi Dong Jin Joo Woo Yeol Baek Young Chul Suh Won Taek Oh Jae Yong Cho Sang Chul Lee Sang Kyum Kim Hyang Joo Ryu Kyung Ock Jeon Won Jai Lee Jong Won Hong Source Type: research

Evaluation of the Regulatory Required Post-Authorization Safety Study for Propacetamol: Nested Case-Control and Case-Time-Control Studies
CONCLUSION: In both nested case-control and CTC analyses, propacetamol was not associated with an increased risk of anaphylaxis, thrombosis, or SJS. The findings from this study, which used routinely collected clinical data, provide reassuring real-world evidence regarding the safety of propacetamol in a nationwide population to support regulatory decision-making.PMID:38288652 | PMC:PMC10827637 | DOI:10.3349/ymj.2023.0207 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungho Bea Dongwon Yoon Han Eol Jeong Juhong Jung Seung-Mok Park Juhee Jeon Young-Min Ye Jae-Hyun Lee Ju-Young Shin Source Type: research

Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging
Yonsei Med J. 2024 Feb;65(2):55-69. doi: 10.3349/ymj.2023.0131.ABSTRACTMitochondria function as platforms for bioenergetics, nutrient metabolism, intracellular signaling, innate immunity regulators, and modulators of stem cell activity. Thus, the decline in mitochondrial functions causes or correlates with diabetes mellitus and many aging-related diseases. Upon stress or damage, the mitochondria elicit a series of adaptive responses to overcome stress and restore their structural integrity and functional homeostasis. These adaptive responses to low-level or transient mitochondrial stress promote health and resilience to up...
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Se Hee Min Gil Myoung Kang Jae Woo Park Min-Seon Kim Source Type: research

Alterations in Plasma Cytokine Levels in Korean Children with Autism Spectrum Disorder
CONCLUSION: We confirmed that Korean children with ASD showed altered immune function and unique cytokine expression patterns distinct from TDC.PMID:38288647 | PMC:PMC10827638 | DOI:10.3349/ymj.2023.0362 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Songjoo Shim Sungji Ha Juli Choi Ho-Keun Kwon Keun-Ah Cheon Source Type: research

Aetiology and Prognosis of Encephalitis in Korean Children: A Retrospective Single-Centre Study, 2005-2020
CONCLUSION: This large-scale study showed that autoimmune and infectious causes accounted for a significant proportion of encephalitis in Korean children. Further studies are needed to determine whether early targeted treatment following early diagnosis leads to a favourable prognosis in these populations.PMID:38288648 | PMC:PMC10827636 | DOI:10.3349/ymj.2023.0250 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Ahra Kim Minyoung Kim Jee Yeon Baek Ji Young Lee Se Hee Kim Ji-Man Kang Jong Gyun Ahn Hoon-Chul Kang Source Type: research