High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
Advancements in Diabetic Kidney Disease Management: Integrating Innovative Therapies and Targeted Drug Development
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00026.2024. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of chronic kidney disease and affects approximately 40% of diabetic individuals. Cases of DKD continue to rise globally as the prevalence of diabetes mellitus increases, with an estimated 415 million people living with diabetes in 2015 and a projected 642 million by 2040. DKD is associated with significant morbidity and mortality, representing 34% and 36% of all chronic kidney disease deaths in men and women, respectively. Common co-morbidities including hypertension an...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Shaarav Ghose Matthew Satariano Saichidroopi Korada Thomas Cahill Raghav Shah Rupesh Raina Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
The long-term effect on functional outcome of endoscopic brainwashing for intraventricular hemorrhage compared to external ventricular drainage alone: A retrospective single-center cohort study
CONCLUSION: Comparing EBW and EVD, patients submitted to the former treatment have the highest modified Graeb scores and, at a long-term follow-up, have better outcomes, demonstrated by the improvement of the patients in the follow-up.PMID:38628520 | PMC:PMC11021092 | DOI:10.25259/SNI_37_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Talita Helena Martins Sarti Marcos Devanir Silva da Costa Daniel Paz Araujo Rodrigo Akira Watanabe Samuel Tau Zymberg Ítalo Capraro Suriano Sergio Cavalheiro Feres Chaddad-Neto Source Type: research
Impact of Age on Prescribing Patterns of Cardiovascular Medications in Older Japanese Patients with Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Study
CONCLUSIONS: This study suggests that age is a potential barrier to the treatment of patients with CKD and highlights the need to establish individualized treatment strategies for cardiovascular protection in this population.PMID:38631869 | DOI:10.5551/jat.64798 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 17, 2024 Category: Cardiology Authors: Shigeru Tanaka Hiromasa Kitamura Kazuhiko Tsuruya Takanari Kitazono Toshiaki Nakano FKR Study Collaboration Group Source Type: research
Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation
CONCLUSIONS: Taken together, our findings reveal that NR4A3-mediated histone lactylation is a novel metabolome-epigenome signaling cascade mechanism that participates in the pathogenesis of medial arterial calcification.PMID:38629274 | DOI:10.1161/CIRCRESAHA.123.323699 (Source: Circulation Research)
Source: Circulation Research - April 17, 2024 Category: Cardiology Authors: Wenqi Ma Kangni Jia Haomai Cheng Hong Xu Zhigang Li Hang Zhang Hongyang Xie Lingfang Zhuang Ziyang Wang Yuke Cui Hang Sun Lei Yi Zhiyong Chen Shengzhong Duan Motoaki Sano Keiichi Fukuda Lin Lu Fei Gao Ruiyan Zhang Xiaoxiang Yan Source Type: research
Advancements in Diabetic Kidney Disease Management: Integrating Innovative Therapies and Targeted Drug Development
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00026.2024. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of chronic kidney disease and affects approximately 40% of diabetic individuals. Cases of DKD continue to rise globally as the prevalence of diabetes mellitus increases, with an estimated 415 million people living with diabetes in 2015 and a projected 642 million by 2040. DKD is associated with significant morbidity and mortality, representing 34% and 36% of all chronic kidney disease deaths in men and women, respectively. Common co-morbidities including hypertension an...
Source: Am J Physiol Endocri... - April 17, 2024 Category: Endocrinology Authors: Shaarav Ghose Matthew Satariano Saichidroopi Korada Thomas Cahill Raghav Shah Rupesh Raina Source Type: research
Physical functional capacity assessment in children with chronic kidney disease: A cross sectional observational study
CONCLUSION: Muscle strength and functional capacity were most impaired in Indian children on hemodialysis and best preserved in KTR.PMID:38629745 | DOI:10.5414/CN111295 (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Himani Goswami Harda Shah Kinnari Vala Shahenaz Kapadia Bharat Tiwari Anshuman Saha Source Type: research
Application of improved glomerular filtration rate estimation by a neural network model in patients with neurogenic lower urinary tract dysfunction
CONCLUSION: The MLP-based model offered significant advantages in estimating GFR in Chinese NLUTD patients, and its application could be suggested in clinical practice.PMID:38629744 | DOI:10.5414/CN111150 (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Ying-Chun Ma Yang Xie Limin Liao Source Type: research
Uremia Impedes Skeletal Myocyte Myomixer Expression and Fusogenic Activity
In patients with chronic kidney disease (CKD), skeletal muscle mass and function are known to occasionally decline. However, the muscle regeneration and differentiation process in uremia has not been extensively studied. In mice with CKD induced by adenine-containing diet, the tibialis anterior muscle injured using a barium chloride injection method recovered poorly as compared to control mice. In the cultured murine skeletal myocytes, stimulation with indoxyl sulfate (IS), a representative uremic toxin, morphologically jeopardized the differentiation, which was counteracted by L-ascorbic acid (L-AsA) treatment. (Source: A...
Source: American Journal of Pathology - April 17, 2024 Category: Pathology Authors: Takaaki Higashihara, Motoki Odawara, Hiroshi Nishi, Takehito Sugasawa, Yumika Suzuki, Satoshi Kametaka, Reiko Inagi, Masaomi Nangaku Tags: Regular Article Source Type: research
Advances in uremic toxin detection and monitoring in the management of chronic kidney disease progression to end-stage renal disease
Analyst, 2024, Accepted Manuscript DOI: 10.1039/D4AN00057A, Critical ReviewHan Lee, Kuan-Hung Liu, Yu-Hsuan Yang, Jiunn-Der Liao, Bo-shen Lin, Zheng-Zhe Wu, Alice Chang, Chin-Chung Tseng, Ming-Cheng Wang, Yau-Sheng Tsai Patients with end-stage kidney disease (ESKD) rely on dialysis to remove toxins and stay alive. However, hemodialysis alone is insufficient to completely remove all/major uremic toxins, resulting in the accumulation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - April 17, 2024 Category: Chemistry Authors: Han Lee Source Type: research
Kidney and Cardiovascular Effectiveness of Empagliflozin Compared to Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes
Placebo-controlled trials of sodium-glucose cotransporter-2 inhibitors (SGLT2i) demonstrate kidney and cardiovascular benefits for people with type 2 diabetes (T2D) and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular effectiveness of empagliflozin to dipeptidyl peptidase-4 inhibitors (DPP4i), a commonly prescribed antiglycemic medication, in a diverse population with and without CKD. Using electronic health record data from 20 large US health systems, we leveraged propensity overlap weighting to compare outcomes for empagliflozin and DPP4i initiators with T2D between 2016 and ...
Source: The American Journal of Cardiology - April 17, 2024 Category: Cardiology Authors: Daniel Edmonston, Hillary Mulder, Elizabeth Lydon, Karen Chiswell, Zachary Lampron, Christina Shay, Keith Marsolo, W. Schuyler Jones, Javed Butler, Raj C. Shah, Alanna M. Chamberlain, Daniel E. Ford, Howard S. Gordon, Wenke Hwang, Alexander Chang, Ajaykum Source Type: research
Epithelial cell states associated with kidney and allograft injury
Nature Reviews Nephrology, Published online: 17 April 2024; doi:10.1038/s41581-024-00834-0This Review describes parallels in the injury mechanisms that underlie acute kidney injury, chronic kidney disease and allograft injury, and explains how our understanding of the molecular changes that occur in epithelia in the context of kidney disease may contribute to the therapeutic targeting of specific epithelial cell phenotypes for the treatment of transplantation complications. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Christian Hinze Svjetlana Lovric Philip F. Halloran Jonathan Barasch Kai M. Schmidt-Ott Source Type: research
Thiazides in kidney transplant recipients: skin in the game
Nature Reviews Nephrology, Published online: 17 April 2024; doi:10.1038/s41581-024-00839-9Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in patients with severe chronic kidney disease. However, prolonged exposure to these photosensitizing drugs could translate into increased risk of squamous cell carcinoma and post-transplant diabetes in the already extremely vulnerable kidney transplant population. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Steven Van Laecke Source Type: research
Shen Shuai II recipe improves renal hypoxia to attenuate renal injury in 5/6 renal ablation/infarction rats and effect evaluation using blood oxygenation level-dependent functional magnetic resonance imaging
Conclusion: The degree of renal oxygenation reduction is correlated with the severity of renal injury in CKD. SSR can improve renal hypoxia to attenuate renal injury in 5/6 (A/I) rats of CKD.PMID:38622926 | DOI:10.1080/0886022X.2024.2338565 (Source: Renal Failure)
Source: Renal Failure - April 16, 2024 Category: Urology & Nephrology Authors: Yizeng Xu Fang Lu Meng Wang Lingchen Wang Chaoyang Ye Shuohui Yang Chen Wang Source Type: research
