Glucose Color Index: Development and Validation of a Novel Measure of the Shape of Glycemic Variability
CONCLUSION: We developed and validated the GCI, a novel CGM metric that captures the shape of glucose variability using the periodogram signal decomposition. Glucose Color Index was reliable within participants over a three-month period and associated with diabetes comorbidities. The GCI suggests a promising avenue toward the development of CGM metrics which more fully incorporate time series information.PMID:38641966 | DOI:10.1177/19322968241245654 (Source: Atherosclerosis)
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Joseph Sartini Michael Fang Mary R Rooney Elizabeth Selvin Josef Coresh Scott Zeger Source Type: research
Carotid Endarterectomy and Transcarotid Artery Revascularization can be Performed with Acceptable Morbidity and Mortality in Patients with Chronic Kidney Disease
Patients with chronic kidney disease (CKD) are considered a high-risk population, and the optimal approach to the treatment of carotid disease remains unclear. Thus, we compared outcomes following carotid revascularization for patients with CKD by operative approach of carotid endarterectomy (CEA), transfemoral carotid artery stenting (TFCAS), and transcarotid arterial revascularization (TCAR). (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 20, 2024 Category: Surgery Authors: Norma Elizaga, Rahul Ghosh, Nallely Saldana-Ruiz, Marc Schermerhorn, Peter Soden, Kirsten Dansey, Sara L. Zettervall Source Type: research
Effects of empagliflozin in patients with chronic kidney disease from Japan: exploratory analyses from EMPA –KIDNEY
ConclusionsEmpagliflozin safely reduced the risk of “kidney disease progression or cardiovascular death” in patients with CKD, with consistent effects in participants from Japan. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2024 Category: Urology & Nephrology Source Type: research
Effects of 1-week inpatient multidisciplinary care for chronic kidney disease prior to outpatient collaborative care
ConclusionEducational hospitalization prior to outpatient collaborative care is beneficial for preventing hemodialysis induction using a central venous catheter and postponing dialysis induction. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2024 Category: Urology & Nephrology Source Type: research
Anterior and posterior ischemic optic neuropathy in a child with focal segmental glomerulosclerosis on hemodialysis
ConclusionsThe exact cause of our patient ’s simultaneous bilateral anterior and posterior ION, confirmed via MRI and fundoscopic examination, is unclear; however, is likely secondary to a combination of fluctuating blood pressure, anemia, anephric status, and hemodialysis. This highlights the need for close blood pressure monitoring, man agement of anemia, and more diligent ophthalmologic screening in pediatric patients on chronic hemodialysis. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Volume expansion mitigates Shiga toxin-producing E. coli-hemolytic uremic syndrome in children
ConclusionsThis study suggests that volume expansion may be associated with the mitigation of the acute course of STEC-HUS, especially severe neurological involvement and the development of CKD. Prospective trials should lead to standardized protocols for volume expansion in children with STEC-HUS.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Systematic Review and Network Meta-analysis for the American College of Physicians
CONCLUSION: In adults with T2DM, SGLT2 inhibitors and GLP1 agonists (but not DPP4 inhibitors, insulin, or tirzepatide) reduce all-cause mortality and MACE compared with usual care. SGLT2 inhibitors reduce CKD progression and heart failure hospitalization and GLP1 agonists reduce stroke compared with usual care. Serious adverse events and severe hypoglycemia are less frequent with SGLT2 inhibitors and GLP1 agonists than with insulin or SU.PRIMARY FUNDING SOURCE: American College of Physicians. (PROSPERO: CRD42022322129).PMID:38639549 | DOI:10.7326/M23-1490 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 19, 2024 Category: Internal Medicine Authors: Tyler Drake Adrienne Landsteiner Lisa Langsetmo Roderick MacDonald Maylen Anthony Caleb Kalinowski Kristen Ullman Charles J Billington Anjum Kaka Shahnaz Sultan Timothy J Wilt Source Type: research
Newer Pharmacologic Treatments in Adults With Type 2 Diabetes: A Clinical Guideline From the American College of Physicians
Ann Intern Med. 2024 Apr 19. doi: 10.7326/M23-2788. Online ahead of print.ABSTRACTDESCRIPTION: The American College of Physicians (ACP) developed this clinical guideline to update recommendations on newer pharmacologic treatments of type 2 diabetes. This clinical guideline is based on the best available evidence for effectiveness, comparative benefits and harms, consideration of patients' values and preferences, and costs.METHODS: This clinical guideline is based on a systematic review of the effectiveness and harms of newer pharmacologic treatments of type 2 diabetes, including glucagon-like peptide-1 (GLP-1) agonists, a ...
Source: Annals of Internal Medicine - April 19, 2024 Category: Internal Medicine Authors: Amir Qaseem Adam J Obley Tatyana Shamliyan Lauri A Hicks Curtis S Harrod Carolyn J Crandall Clinical Guidelines Committee of the American College of Physicians Source Type: research
Medical database analysis of the association between kidney function and achievement of glycemic control in older Japanese adults with type 2 diabetes who started with oral antidiabetic drugs
ConclusionsIn older Japanese adults with type 2 diabetes, those with a lower estimated glomerular filtration rate were more likely to achieve hemoglobin A1c of<7.0%. To safely manage blood glucose levels in older adults with chronic kidney disease, physicians should remain vigilant about the risk of iatrogenic hypoglycemia. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 19, 2024 Category: Endocrinology Authors: Ryo Suzuki,
Kiyoyasu Kazumori,
Tatsuya Usui,
Masahiko Shinohara Tags: Original Article Source Type: research
Exploring the Acceptability of a Community-Enhanced Intervention to Improve Decision Support Partnership
1. Describe and understand the current literature gap regarding advanced illness decision-making for patients with chronic kidney disease and their family caregivers.2. Explain how decision support training can be used to positively influence how patients with chronic kidney disease engage in the decision-making process and in future serious illness planning. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Shena Gazaway, Tamara Nix Parker, Claretha Lyas, James Nicholas Odom Source Type: research
A Community-Based Nephrology and Palliative Care Partnership to Improve Advanced Chronic Kidney Disease Care
1. Describe how to develop an integrated palliative care approach to advanced CKD care through a community-based partnership.2. Describe the implementation of a community-based collaboration for advanced CKD as a model to apply with other advanced chronic diseases. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Christine Khandelwal, Dwan Kelsey Source Type: research
Embedding Palliative Care (PC) in Nephrology Clinic: The Role of PC in Patients with Advanced Chronic Kidney Disease
1. Examine a collaborative approach for developing criteria for nephrologists to consider referring patients with advanced CKD to palliative care, exploring the potential role of race in this process.2. Describe the PC needs of patients with advanced CKD, by recalling the content of palliative care visits with patients with advanced CKD. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Carlo S. Basilio, Prasanti Ravipati, Elizabeth Figuracion, Mary K. Buss Source Type: research
Are there lost opportunities in chronic kidney disease? A region-wide cohort study
Conclusions
While we noted underdiagnosis and undertreatment of CKD in this large contemporary population, we also identified a substantial realisable potential to improve CKD outcomes and reduce its burden by treating patients early with guideline-directed pharmacological therapy. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Sundström, J., Norhammar, A., Karayiannides, S., Bodegard, J., Gustafsson, S., Cars, T., Eriksson Svensson, M., Ärnlöv, J. Tags: Open access, Epidemiology Source Type: research
Even Low Levels of Albumin in Urine Tied to Worsened Kidney Disease
For decades, researchers characterized normal albuminuria as a urine albumin-creatinine ratio of less than 30 mg/g. That has led some clinicians to believe that patients with lower ratios don ’t need additional treatment. But a new study in Annals of Internal Medicine challenges that assumption by showing that even low levels of albuminuria are a risk factor for kidney failure in people with chronic kidney disease. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 19, 2024 Category: General Medicine Source Type: research
Endogenous adenine as a key player in diabetic kidney disease progression: an integrated multiomics approach
Adenine is 1 of the 2 nitrogenous bases that form purine nucleotides in nucleic acids. Under physiological conditions, exogenous adenine is absorbed through the intestines, metabolized into several adenine derivatives, and excreted as uric acid by the kidneys. High doses of exogenous adenine can be metabolized into 2,8-dihydroxyadenine, which is deposited as crystals in the kidney tubules or interstitium, causing tubulointerstitial fibrosis, inflammation, and tubular atrophy.1 This approach is used to generate the adenine-induced chronic kidney disease (CKD) animal model, which has been widely used as a stable CKD model. (...
Source: Kidney International - April 18, 2024 Category: Urology & Nephrology Authors: Yu Ah Hong, Masaomi Nangaku Tags: Nephrology Digest Source Type: research
