Improving outcomes in atherosclerotic renovascular disease: importance of clinical presentation and multi-disciplinary review
CONCLUSIONS: Multi-disciplinary team discussion successfully identified a group of patients more likely to benefit from revascularization based on 3 key factors: clinical presentation, severity of the renal artery lesion and the state of the kidney beyond the stenotic lesion. In this way, a large proportion of patients can clinically improve after revascularization if their outcomes are considered according to the nature of their clinical presentation.PMID:38594599 | DOI:10.1007/s40620-024-01902-1 (Source: Journal of Nephrology)
Source: Journal of Nephrology - April 9, 2024 Category: Urology & Nephrology Authors: Áine M de Bhailis Edward Lake Constantina Chrysochou Darren Green Rajkumar Chinnadurai Philip A Kalra Source Type: research
Cardiogenic shock and chronic kidney disease: Dangerous liaisons
CONCLUSIONS: Cardiogenic shock and CKD are frequent "cross-talking" conditions with limited therapeutic options, resulting in higher rates of death at 1month and 1year. RRT is a strong predictor of death, regardless of preexisting CKD. Multidisciplinary teams involving cardiac and kidney physicians are required to provide integrated care for patients with failure of both organs.PMID:38594150 | DOI:10.1016/j.acvd.2024.01.006 (Source: Archives of Cardiovascular Diseases)
Source: Archives of Cardiovascular Diseases - April 9, 2024 Category: Cardiology Authors: Miloud Cherbi Eric Bonnefoy Etienne Puymirat Nicolas Lamblin Edouard Gerbaud Laurent Bonello Bruno Levy Pascal Lim Laura Muller Hamid Merdji Gr égoire Range Emile Ferrari Meyer Elbaz Hadi Khachab Jeremy Bourenne Marie-France Seronde Nans Florens Guillaum Source Type: research
Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy
CONCLUSION: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.PMID:38591824 | DOI:10.1590/2175-8239-JBN-2023-0175en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Andre Kakinoki Teng Eduardo Jorge Duque Shirley Ferraz Crispilho Wagner Domingues Vanda Jorgetti Luciene M Dos Reis Rosilene M Elias Rosa Maria Affonso Moys és Source Type: research
Estimated glomerular filtration rate in clinical practice: Consensus positioning of the Brazilian Society of Nephrology (SBN) and Brazilian Society of Clinical Pathology and Laboratory Medicine (SBPC/ML)
J Bras Nefrol. 2024 Apr 5;46(3):e20230193. doi: 10.1590/2175-8239-JBN-2023-0193en. eCollection 2024.ABSTRACTChronic kidney disease (CKD) represents one of today's main public health problems. Serum creatinine measurement and estimation of the glomerular filtration rate (GFR) are the main tools for evaluating renal function. There are several equations to estimate GFR, and CKD-EPI equation (Chronic Kidney Disease - Epidemiology) is the most recommended one. There are still some controversies regarding serum creatinine measurement and GFR estimation, since several factors can interfere in this process. An important recent ch...
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Gianna Mastroianni Kirsztajn Geraldo Bezerra da Silva Junior Artur Quintiliano Bezerra da Silva Hugo Abensur Jo ão Egídio Romão Junior Marcus Gomes Bastos Viviane Calice-Silva Lilian Pires de Freitas do Carmo Tain á Veras de Sandes-Freitas Patr ícia Source Type: research
Occupational risks associated with chronic kidney disease of non-traditional origin (CKDnt) in Brazil: it is time to dig deeper into a neglected problem
J Bras Nefrol. 2024 Apr 5;46(3):e20230123. doi: 10.1590/2175-8239-JBN-2023-0123en. eCollection 2024.ABSTRACTIn the past decades, an epidemic of chronic kidney disease (CKD) has been associated with environmental and occupational factors (heat stress from high workloads in hot temperatures and exposure to chemicals, such as pesticides and metals), which has been termed CKD of non-traditional origin (CKDnt). This descriptive review aims to present recent evidence about heat stress, pesticides, and metals as possible causes of CKDnt and provide an overview of the related Brazilian regulation, enforcement, and health surveilla...
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Rafael Junqueira Buralli Polianna L M Moreira Albuquerque Cintia da Espiritu Santo Viviane Calice-Silva Fabiana Baggio Nerbass Source Type: research
Higher cardiometabolic index was independently associated with higher chronic kidney disease risk in the general population
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 9, 2024 Category: Urology & Nephrology Source Type: research
Urinary cadmium was linearly and positively associated with cardiac infarction/injury score and subclinical myocardial injury in the general population without cardiovascular diseases and chronic kidney disease
ConclusionUrinary cadmium was linearly and positively associated with CIIS and SC-MI in the general population without CVDs and CKD. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 9, 2024 Category: Urology & Nephrology Source Type: research
Safety of cinacalcet in children and adolescents with chronic kidney disease-mineral bone disorder: systematic review and proportional meta-analysis of case series
Conclusions and implications of key findingsIf used in the pediatric population, the calcimimetic cinacalcet should be carefully monitored for serum calcium levels and attention to possible adverse events, especially in children under 50 months.Systematic review registration number (PROSPERO register)CRD42019132809. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 9, 2024 Category: Urology & Nephrology Source Type: research
The associations of weekend warrior and other physical activity patterns with the risk of all-cause and cardiovascular disease mortality in people with diabetes mellitus and chronic kidney disease: from NHANES 2007 –2020
ConclusionIn a population of DM and CKD, the weekend warrior pattern was similar to regular activity to lower the risk of all-cause mortality, compared with inactivity. The weekend warrior pattern was recommended for people who only have time to exercise on the weekend. However, longer and larger sample cohort studies are needed to validate our findings. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 9, 2024 Category: Urology & Nephrology Source Type: research
Short or long sleep duration was associated with chronic kidney disease in a Chinese nationwide cohort study
ConclusionShort or long sleep duration was associated with CKD in the general population. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 9, 2024 Category: Urology & Nephrology Source Type: research
Long-term exposure to fine particulate matter constituents in relation to chronic kidney disease: evidence from a large population-based study in China
This study sought to examine the association between long-term exposure to major PM2.5 constituents and CKD and look for potential constituents contributing substantially to CKD. This study included 81,137 adults from the 2018 to 2019 baseline survey of China Multi-Ethnic Cohort. CKD was defined by the estimated glomerular filtration rate. Exposure concentration data of 7 major PM2.5 constituents were assessed by satellite remote sensing. Logistic regression models were used to estimate the effect of each PM2.5 constituent exposure on CKD. The weighted quantile sum regression was used to estimate the effect of mixed exposu...
Source: Environmental Geochemistry and Health - April 9, 2024 Category: Environmental Health Source Type: research
Effects of the novel sodium-dependent phosphate cotransporter 2b inhibitor DZ1462 on hyperphosphatemia in chronic kidney disease
CONCLUSIONS: This study revealed that a GI-restricted NPT2b inhibitor DZ1462 potently inhibits NPT2b in vitro and blocks intestinal phosphate uptake in multiple animal models with potential to reduce various cardiovascular events in CKD models. Therefore, DZ1462 may be useful to treat renal disease patients who have shown an unsatisfactory response to phosphate binders.PMID:38586086 | PMC:PMC10994808 | DOI:10.62347/UGTW5471 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Xiao Lu Ling-Zhi Yu Qiu-Li Guo Lin Zhang Shan-Xiang Jiang Source Type: research
CD44 expression in renal tubular epithelial cells in the kidneys of rats with cyclosporine-induced chronic kidney disease
In this study, we investigated CD44 expression and its role in renal fibrogenesis in a cyclosporine (CyA) rat model of CKD. Seven-week-old male Sprague-Dawley rats fed a low-salt diet were subcutaneously administered CyA (0, 15, or 30 mg/kg) for 28 days. CD44 was expressed in atrophic, dilated, and hypertrophic TECs in the fibrotic lesions of the CyA groups. These TECs were collected by laser microdissection and evaluated by microarray analysis. Gene ontology analysis suggested that these TECs have a mesenchymal phenotype, and pathway analysis identified CD44 as an upstream regulator of fibrosis-related genes, including fi...
Source: Journal of Toxicologic Pathology - April 8, 2024 Category: Toxicology Authors: Kohei Matsushita Takeshi Toyoda Hirotoshi Akane Tomomi Morikawa Kumiko Ogawa Source Type: research
Effects of the novel sodium-dependent phosphate cotransporter 2b inhibitor DZ1462 on hyperphosphatemia in chronic kidney disease
CONCLUSIONS: This study revealed that a GI-restricted NPT2b inhibitor DZ1462 potently inhibits NPT2b in vitro and blocks intestinal phosphate uptake in multiple animal models with potential to reduce various cardiovascular events in CKD models. Therefore, DZ1462 may be useful to treat renal disease patients who have shown an unsatisfactory response to phosphate binders.PMID:38586086 | PMC:PMC10994808 | DOI:10.62347/UGTW5471 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Xiao Lu Ling-Zhi Yu Qiu-Li Guo Lin Zhang Shan-Xiang Jiang Source Type: research
CD44 expression in renal tubular epithelial cells in the kidneys of rats with cyclosporine-induced chronic kidney disease
In this study, we investigated CD44 expression and its role in renal fibrogenesis in a cyclosporine (CyA) rat model of CKD. Seven-week-old male Sprague-Dawley rats fed a low-salt diet were subcutaneously administered CyA (0, 15, or 30 mg/kg) for 28 days. CD44 was expressed in atrophic, dilated, and hypertrophic TECs in the fibrotic lesions of the CyA groups. These TECs were collected by laser microdissection and evaluated by microarray analysis. Gene ontology analysis suggested that these TECs have a mesenchymal phenotype, and pathway analysis identified CD44 as an upstream regulator of fibrosis-related genes, including fi...
Source: Journal of Toxicologic Pathology - April 8, 2024 Category: Toxicology Authors: Kohei Matsushita Takeshi Toyoda Hirotoshi Akane Tomomi Morikawa Kumiko Ogawa Source Type: research
