Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang ’s method
ConclusionsCT-AC may allow brain perfusion SPECT to reflect more exact neuropathic changes in MCI that would cause progression of early AD. CT-AC in conjunction with voxel-based statistical analysis could possess higher diagnostic accuracy for exacerbation of disease implying early Alzheimer changes in MCI patients, with decreases in cerebral perfusion in the left temporal and limbic lobes representing good indicators. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 24, 2020 Category: Nuclear Medicine Source Type: research

Applying Wells score to inconclusive perfusion only modified PIOPED II (Prospective Investigation of Pulmonary Embolism Diagnosis II) readings in order  to optimize the lung scintigraphy diagnostic yield in acute pulmonary embolism detection
ConclusionAdding Wells score to non-diagnostic scans allowed identification of PE to be done reliably, and provided further insight into how lung scintigraphy in conjunction with clinical assessment is a practical strategy not only for the patients unfit for performing CTPA but also in all the patients referred for PE evaluation. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 23, 2020 Category: Nuclear Medicine Source Type: research

Preoperative F-18 fluorocholine PET/CT for the detection of hyperfunctioning parathyroid glands in patients with secondary or tertiary hyperparathyroidism: comparison with Tc-99m sestamibi scan and neck ultrasound
AbstractObjectivesCurrently, neck ultrasound is the preferred preoperative imaging in patients with secondary/tertiary hyperparathyroidism, and the use of Tc-99m sestamibi scan is limited in these patients. We conducted this study to compare the diagnostic utilities of F-18 fluorocholine PET/CT, Tc-99m sestamibi scintigraphy, and neck ultrasound for localizing hyperfunctioning parathyroid glands in secondary/tertiary hyperparathyroidism.MethodsWe prospectively enrolled 30 dialysis patients with a diagnosis of secondary/tertiary hyperparathyroidism; of these, 27 participants underwent all three imaging modalities, including...
Source: Annals of Nuclear Medicine - May 20, 2020 Category: Nuclear Medicine Source Type: research

Physiological 18F-FDG uptake in the normal adult anal canal: evaluation by PET/CT
ConclusionsPET/CT scans occasionally showed high FDG uptake in the anal canal of healthy adults. Comparing the SUVmax values of liver FDG uptake may help differentiate between normal tissue and anal cancer. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 19, 2020 Category: Nuclear Medicine Source Type: research

Effects of animal handling on striatal DAT availability in rats
ConclusionsIn conclusion, the SBR of striatum was increased after anesthesia by isoflurane and fasting. When designing an experiment using DAT imaging, the effects of isoflurane and fasting should be considered. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 18, 2020 Category: Nuclear Medicine Source Type: research

Does bone scintigraphy still have a role in the era of 68  Ga-PSMA PET/CT in prostate cancer?
ConclusionThis study has shown that 68  Ga-PSMA PET/CT overcomes the limitations of BS and proves superiority in detecting bone metastases, even in patients with SPECT/CT. Our findings present important implications that 68 Ga-PSMA PET/CT can replace BS in future practice. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 11, 2020 Category: Nuclear Medicine Source Type: research

In vitro/in vivo assessment of the targeting ability of [ 99m Tc] Tc-labeled an aptide specific to the extra domain B of fibronectin (APT EDB ) for colorectal cancer
ConclusionsAlthough more studies are required to find out the full potential of this radio-ligand as an imaging probe, the present results nevertheless provide useful information about [99mTc] Tc-APTEDB, which might be beneficial in design and development of new [99mTc] Tc-APTEDB for efficient targeting of tumor in vivo. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 10, 2020 Category: Nuclear Medicine Source Type: research

Synthesis and evaluation of novel radioiodinated anthranilate derivatives for in vivo imaging of vascular endothelial growth factor receptor with single-photon emission computed tomography
Conclusion[125I]p-NPAM may have potential applications as a lead compound for future development of a clinically usable VEGFR imaging probe for SPECT. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 8, 2020 Category: Nuclear Medicine Source Type: research

Improvement in cognitive decline after indirect bypass surgery in adult moyamoya disease: implication of 15 O- gas positron emission tomography
ConclusionAdult patients with MMD might show improvement in their cognitive decline after successful indirect bypass surgery if they have a severely increased regional OEF before the surgery and an increased regional CMRO2 after the surgery.Clinical trial registrationURL:https://www.umin.ac.jp/ctr/. Unique identifier: UMIN000027949. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 6, 2020 Category: Nuclear Medicine Source Type: research

Methods for analyzing binary of data clusters into intestinal segments of the patients
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 2, 2020 Category: Nuclear Medicine Source Type: research

Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [ 123 I]IIMU, in healthy volunteers
ConclusionIn this preliminary study, [123I]IIMU was safely administered to healthy adults, and its potential clinical use in TP imaging was revealed. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 2, 2020 Category: Nuclear Medicine Source Type: research

Oral 67 Gallium Citrate Scintigraphy in assessment of inflammatory activity of Crohn ’s disease: methodological issues on accuracy and agreement
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 30, 2020 Category: Nuclear Medicine Source Type: research

An impact of microscopic positive margin on incomplete response after I-131 treatment in differentiated thyroid cancer
ConclusionsMicroscopic positive margin was found to be significantly associated with incomplete response after I-131 therapy in patients with differentiated thyroid cancer after adjusting for tumor size, ETE, and cervical lymph node metastasis and also had a trend toward being associated with incomplete response after adjusting for pre-ablative Tg. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 22, 2020 Category: Nuclear Medicine Source Type: research

Assessment of lung glucose uptake in patients with systemic lupus erythematosus pulmonary arterial hypertension: a quantitative FDG-PET imaging study
AbstractPurposePulmonary arterial hypertension (PAH) is a recognized complication of systemic lupus erythematosus (SLE-PAH) patients and its lung pathology shares similarity to idiopathic PAH (IPAH) with distinctive inflammatory feature. FDG-PET reports glucose metabolism from both hyperproliferative and inflammatory cellular elements of vascular pathology in PAH. We explored the application of FDG-PET in reporting SLE-PAH pulmonary vascular pathology.MethodsSixty-minute dynamic FDG-PET imaging was applied in 14 SLE-PAH patients, 20 IPAH patients and 10 healthy volunteers. Patlak analysis was used to quantify lung FDG upta...
Source: Annals of Nuclear Medicine - April 20, 2020 Category: Nuclear Medicine Source Type: research

AI approach of cycle-consistent generative adversarial networks to synthesize PET images to train computer-aided diagnosis algorithm for dementia
DiscussionOur results show that CycleGAN has the potential to generate a sufficient number of training images for CAD of dementia. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 20, 2020 Category: Nuclear Medicine Source Type: research

A diagnostic strategy for Lewy body disease using DAT-SPECT, MIBG and Combined index
ConclusionIn the diagnosis of LBD, DAT-SPECT, MIBG myocardial scintigraphy, and Combined index may be reliable indices. In particular, MIBG myocardial scintigraphy was the specific modality for LBD diagnosis. Understanding the effectiveness and limits of DAT-SPECT and MIBG myocardial scintigraphy and using both properly will lead to a more accurate diagnosis and better treatment. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 16, 2020 Category: Nuclear Medicine Source Type: research

Prognostic value of pretreatment tumor-to-blood standardized uptake ratio (SUR) in rectal cancer
ConclusionsIn our study, SUR was the only F-18 FDG PET/CT parameter found to be significant for PFS. The development of new parameters can increase the prognostic value of F-18 FDG PET/CT. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 15, 2020 Category: Nuclear Medicine Source Type: research

Radiation exposure in nurses during care of 131 I-MIBG therapy for pediatric patients with high-risk neuroblastoma
ConclusionIndividual exposure to radiation was well controlled. Nurses who care for pediatric patients needing daily assistance must be aware of the radiation exposure risks, which can be reduced by establishing a care system and monitoring radiation exposure. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 15, 2020 Category: Nuclear Medicine Source Type: research

Standardized thresholds of volume-based PET/CT parameters predicting survival of patients with pancreatic head cancer treated with stereotactic body radiation therapy
AbstractObjectiveTo explore standardized relative thresholds of volume-based parameters on FDG PET/CT, and define the optimal prognosticator among the relative thresholds for patients with locally advanced pancreatic head cancer (LAPHC) treated by stereotactic body radiation therapy (SBRT).MethodsThirty-five patients with LAPHC were enrolled, and all underwent SBRT and baseline FDG PET/CT scan. Maximum standardized uptake value (SUVmax) was measured, and metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated under the relative (30%, 40%, and 50%) thresholds of SUVmax. Survival analysis was performed...
Source: Annals of Nuclear Medicine - April 10, 2020 Category: Nuclear Medicine Source Type: research

Assessing the feasibility of NaF-PET/CT versus FDG-PET/CT to detect abdominal aortic calcification or inflammation in rheumatoid arthritis patients
In this study, 18 RA patients (4 women, 14 men; mean age 56.0  ± 11.7) and 18 healthy controls (4 women, 14 men; mean age 55.8 ± 11.9) were included. The controls were matched to patients by sex and age (± 4 years). All subjects of this study underwent NaF-PET/CT scanning 90 min following the administration of NaF. FDG-PET/CT imaging was perform ed 180 min following intravenous FDG injection. Using OsiriX software, the global mean standardized uptake value (global SUVmean) in abdominal aorta was calculated for both FDG and NaF. The NaF SUVmean and FDG S...
Source: Annals of Nuclear Medicine - April 10, 2020 Category: Nuclear Medicine Source Type: research

Toyama H, Li Y, Hatazawa J, Huang G, Kubota K (eds): PET/CT for inflammatory diseases: basic sciences, typical cases, and review
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 28, 2020 Category: Nuclear Medicine Source Type: research

Retrospective correlation of 68 ga-psma uptake with clinical parameters in prostate cancer patients undergoing definitive radiotherapy
ConclusionsWe demonstrated a correlation between prostate tumor characteristics and PSMA tracer uptake. Patients with serum PSA  >  10 ng/mL, GS >  7, D’Amico high-risk group classification, and pelvic lymph node metastasis had significantly higher SUV than their counterparts. In addition, the primary tumor detection rate was higher in patients with serum PSA >  10 ng/mL and GS >  7. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 27, 2020 Category: Nuclear Medicine Source Type: research

High-dose 131 I-metaiodobenzylguanidine therapy in patients with high-risk neuroblastoma in Japan
AbstractObjectiveThe aim of the study was to investigate the outcomes and prognostic factors of high-dose131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan.MethodsWe retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwent131I-MIBG therapy with an administration dose ranging from 444 to 666  MBq/kg at Kanazawa University Hospital, Japan, between September 2008 and September 2013. We focused on measurements regarding their initial responses, prognostic factors, survivals, and toxicities following131I-MIBG therapy usin...
Source: Annals of Nuclear Medicine - March 26, 2020 Category: Nuclear Medicine Source Type: research

Ten-year prospective evaluation of whole-body cancer screening with multiple modalities including [ 18 F]fluorodeoxyglucose positron emission tomography in a healthy population
ConclusionCancer detection by PET alone was limited. While the high cancer incidence was attributed to the extensive screening, the low cancer and all-cause mortality may indicate the potential value of this type of cancer screening. Cancer incidence increases with aging and it has been shown that continuous screening may reduce the risk caused by the cancer progression. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 21, 2020 Category: Nuclear Medicine Source Type: research

Pet tracers for vulnerable plaque imaging
AbstractMost of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin fibrous cap, large lipid core, and micro-calcifications. Early detection of the presence of a plaque prone to rupture could be life-saving for the patient; however, vulnerable plaques usually cause non-haemodynamically significant stenosis, and anatomical imaging techniques often underestimate, or may not even detect, these ...
Source: Annals of Nuclear Medicine - March 20, 2020 Category: Nuclear Medicine Source Type: research

Ciliated muconodular papillary tumor of the lung: 18F-FDG PET/CT findings of 15 cases
ConclusionCMPT typically shows low FDG uptake. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 14, 2020 Category: Nuclear Medicine Source Type: research

Feasibility of gamma camera-based GFR measurement using renal depth evaluated by lateral scan of 99m Tc-DTPA renography
ConclusionLateral scanning is a feasible procedure to measure renal depth for accurate and reasonable split GFR measurements using99mTc-DTPA renography. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 13, 2020 Category: Nuclear Medicine Source Type: research

Relationships between amyloid levels, glucose metabolism, morphologic changes in the brain and clinical status of patients with Alzheimer ’s disease
ConclusionsCurrent study demonstrated that AV45/FDG/NVol index mapping of the brain is a novel quantitative molecular imaging biomarker that correlates with clinical neurocognitive status and may facilitate more accurate diagnosis, staging, and prognosis of AD. Additional larger scale clinical studies are required to further evaluate the efficacy of this new quantitative index as a diagnostic and prognostic biomarker of AD as well as for the evaluation of safety and efficacy of novel agents undergoing clinical trials for therapy of AD. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 9, 2020 Category: Nuclear Medicine Source Type: research

Diagnosis of bladder cancer using 18 F-labeled α -methyl-phenylalanine tracers in a mouse model
AbstractObjectiveAlthough 2-18F-fluoro-2-deoxy-glucose (18F-FDG) has established roles in the diagnosis of a variety of cancers, it has limited value in the detection of primary/recurrent lesions in the bladder, mainly because of interference by the pooled radioactivity in the urine. Our previous study revealed promising properties ofl- andd-2-18F- α-methyl-phenylalanine (2-18F-FAMP) as radiotracers; i.e., their rapid blood clearance and low renal accumulation. In the present study we evaluated the utility ofl- andd-2-18F-FAMP for imaging bladder cancer in a mouse model.MethodsWe used the human bladder cancer cell li...
Source: Annals of Nuclear Medicine - March 6, 2020 Category: Nuclear Medicine Source Type: research

18 F-FDG maximum standard uptake value predicts PD-L1 expression on tumor cells or tumor-infiltrating immune cells in non-small cell lung cancer
ConclusionHigh SUVmax is linked to PD-L1 expression on TC and IC in our patients with surgically resected non-small cell lung cancer.18F-FDG-PET/CT imaging may be used to predict the PD-L1 expression on TC and IC in NSCLC patients. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 4, 2020 Category: Nuclear Medicine Source Type: research

Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent 177 Lu-DOTATOC therapy
We present a novel Monte Carlo-based voxel-wise dosimetry approach to determine organ- and tumor-specific total tumor doses (TTD).MethodsA cohort of 14 patients with histologically confirmed metastasized NETs of the midgut (11 men, 3 women, 62.3  ± 11.0 years of age) underwent a total of 39 cycles of177Lu-DOTATOC therapy (mean 2.8 cycles, SD  ± 1 cycle). After the first cycle of therapy, regions of interest were defined manually on the SPECT/CT images for the kidneys, the spleen, and all 198 tracer-positive tumor lesions in the field of view. Four SPECT images, taken at 4 ...
Source: Annals of Nuclear Medicine - February 29, 2020 Category: Nuclear Medicine Source Type: research

18 F-FDG PET/CT in lung adenosquamous carcinoma and its correlation with clinicopathological features and prognosis
AbstractObjectiveLung adenosquamous carcinoma (ASC) is a rare histological subtype of non-small cell lung cancer (NSCLC). Due to its rarity, the studies about18F-FDG PET/CT in this kind of pulmonary tumor were quite limited. Thus, this study investigated18F-FDG PET/CT findings in ASC and its correlation with clinicopathological features and clinical outcomes.MethodsPreoperative18F-FDG PET/CT findings and parameters of maximum standard uptake value (SUVmax), metabolic tumor volume and total lesion glycolysis of primary lesion (MTV-P, TLG-P), combination of primary lesion and metastases (MTV-C, TLG-C), and clinicopathologica...
Source: Annals of Nuclear Medicine - February 22, 2020 Category: Nuclear Medicine Source Type: research

Customized FreeSurfer-based brain atlas for diffeomorphic anatomical registration through exponentiated lie algebra tool
ConclusionsCustomized FreeSurfer-based brain atlas for DARTEL tool is easy to create and useful for the analysis of PET and MR images with high adaptability and reliability for broad research purposes. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 22, 2020 Category: Nuclear Medicine Source Type: research

Expert Consensus on clinical application of FDG PET/CT in infection and inflammation
AbstractTo further promote the clinical application of18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in infection and inflammation and standardize the diagnostic process, the experts in relevant fields in China carried out discussion and formed the Expert Consensus on the clinical application of FDG PET/CT in infection and inflammation. This consensus is intended to provide a reference for imaging physicians to select a reasonable diagnostic plan. However, it should be noted that it couldn ’t include or solve all the problems in clinical operation. Imaging physicians and technici...
Source: Annals of Nuclear Medicine - February 21, 2020 Category: Nuclear Medicine Source Type: research

Quantitative evaluation of salivary gland scintigraphy in Sj ögren’s syndrome: comparison of diagnostic efficacy and relationship with pathological features of the salivary glands
ConclusionConventional scintigraphic parameters could be used as simple, reliable, and sensitive indicators for the early diagnosis of SS and determination of disease severity. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 20, 2020 Category: Nuclear Medicine Source Type: research

Accuracy of Oral 67 Gallium Citrate Scintigraphy in assessment of inflammatory activity of Crohn ’s disease
ConclusionsOral67Ga Scintigraphy had similar accuracy and agreement compared to colonoscopy in the identification of inflammatory activity in Crohn ´s Disease. This new approach may be useful and less invasive for long term follow-ups. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 19, 2020 Category: Nuclear Medicine Source Type: research

The value of Bayesian penalized likelihood reconstruction for improving lesion conspicuity of malignant lung tumors on 18 F-FDG PET/CT: comparison with ordered subset expectation maximization reconstruction incorporating time-of-flight model and point spread function correction
AbstractObjectiveTo evaluate the value of Bayesian penalized likelihood (BPL) reconstruction for improving lesion conspicuity of malignant lung tumors on18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography computed tomography (PET/CT) as compared with the ordered subset expectation maximization (OSEM) reconstruction incorporating time-of-flight (TOF) model and point-spread-function (PSF) correction.MethodsTwenty-nine patients with primary or metastatic lung cancers who underwent18F-FDG PET/CT were retrospectively studied. PET images were reconstructed with OSEM  + TOF, OSEM + TOF&thin...
Source: Annals of Nuclear Medicine - February 14, 2020 Category: Nuclear Medicine Source Type: research

Phase I clinical study with different doses of 99m Tc-TRODAT-1 in healthy adults
Conclusions99mTc-TRODAT-1 was safe to use in humans and showed the status of dopaminergic neurons specifically and clearly. The injection dose we suggested was 740  MBq. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 6, 2020 Category: Nuclear Medicine Source Type: research

Acknowledgment to Reviewers
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 6, 2020 Category: Nuclear Medicine Source Type: research

Reply to Zaragori et al.: “Is IDH mutation status associated with 18 F-FDopa PET uptake”
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 4, 2020 Category: Nuclear Medicine Source Type: research

The role of epsilon phenotype in brain glucose consumption in Alzheimer ’s disease
ConclusionsAPO-e4 is related to a major involvement of the frontal cortex confirming its role of risk factor in AD, while APO-3 seems not related to a specific pattern, supporting the hypothesis of neutral/protective role in AD. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 3, 2020 Category: Nuclear Medicine Source Type: research

Is IDH mutation status associated with 18 F-FDopa PET uptake?
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 30, 2020 Category: Nuclear Medicine Source Type: research

Full report on a survey of adverse reactions to radiopharmaceuticals from 1975 to 2017 in Japan
ConclusionsThese results suggest that nuclear medicine staff must be aware of the possibility of adverse reactions from radiopharmaceuticals, despite their rarity. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 27, 2020 Category: Nuclear Medicine Source Type: research

Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm
ConclusionsThe decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 27, 2020 Category: Nuclear Medicine Source Type: research

Clinical implication of myocardial FDG uptake pattern in oncologic PET: retrospective comparison study with stress myocardial perfusion imaging as the reference standard
AbstractObjectiveThe purpose of this study was to determine the clinical implication of the myocardial FDG uptake patterns by comparing with the results of stress myocardial perfusion imaging (MPI) as the reference standard.MethodsBy reviewing the medical records, 86 pairs of stress MPI and FDG PET/CT of 84 patients who underwent stress MPI and oncologic FDG PET/CT in 1  month were included in this study. The patterns of the myocardial FDG uptake were classified into five patterns such as ‘low’, ‘diffuse’, ‘basal ring’, ‘focal high’, and ‘focal defect on diffuse hi...
Source: Annals of Nuclear Medicine - January 24, 2020 Category: Nuclear Medicine Source Type: research

Diagnostic performance of a computer-assisted diagnostic system: sensitivity of BONENAVI for bone scintigraphy in patients with disseminated skeletal metastasis is not so high
ConclusionThe BONENAVI CAD system was partially helpful in diagnosing disseminated skeletal metastasis, but the sensitivity of BONENAVI was not sufficient and underestimated the disseminated skeletal metastasis. Further improvement of this CAD system is necessary to improve the detectability of disseminated skeletal metastasis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 22, 2020 Category: Nuclear Medicine Source Type: research

Correction to: A phase 2, open-label, multi-center study to evaluate the efficacy and safety of 99m Tc-TRODAT-1 SPECT to detect Parkinson ’s disease
The corresponding author of the article would like to remove “Jian Wang” in the author group. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 10, 2020 Category: Nuclear Medicine Source Type: research

Ordered subset expectation maximisation vs Bayesian penalised likelihood reconstruction algorithm in 18F-PSMA-1007 PET/CT
AbstractBackgroundThe aim of the study was to compare widely used ordered subset expectation maximisation (OSEM) algorithm with a new Bayesian penalised likelihood (BPL) Q.Clear algorithm in 18F-PSMA-1007 PET/CT.MethodsWe retrospectively assessed 25 18F-PSMA-1007 PET/CT scans with both OSEM and Q.Clear reconstructions available. Each scan was independently reported by two physicians both in OSEM and Q.Clear. SUVmax, SUVmean and tumour-to-background ratio (TBR) of each lesion were measured. Reports were also compared for their final conclusions and the number and localisation of lesions.ResultsIn both reconstructions the sa...
Source: Annals of Nuclear Medicine - January 4, 2020 Category: Nuclear Medicine Source Type: research

Diagnosis of cardiac sarcoidosis: an era of paradigm shift
AbstractCardiac sarcoidosis is a granulomatous disease that may affect any organ, including the heart. Diagnosis of cardiac sarcoidosis is challenging, given the varied and non-specific clinical presentation and limited sensitivity and specificity of available diagnostic tests. With the growing interest and developments in imaging techniques, cardiac magnetic resonance imaging (CMR) and positron emission tomography (PET) have emerged as important tools in the diagnostic evaluation of patients with suspected cardiac sarcoidosis. These modalities have been given increasing emphasis in successive published diagnostic guidelin...
Source: Annals of Nuclear Medicine - December 17, 2019 Category: Nuclear Medicine Source Type: research

Low-dose radioiodine therapy for patients with intermediate- to high-risk differentiated thyroid cancer
AbstractObjectiveThe efficacy of low-dose radioiodine therapy (RIT) for intermediate-risk or high-risk differentiated thyroid cancer (DTC) patients is controversial. Because of the country's shortage of medical facilities for RIT, 1110-MBq RIT for higher risk DTC patients has been performed on an outpatient basis since 2010 in Japan. Herein, we addressed this issue and attempted to determine prognostic factors for the prediction of RIT outcomes.MethodsWe retrospectively analyzed the cases of 119 patients with papillary thyroid cancer who underwent their first RIT with 1110  MBq radioactive iodine (RAI) following a tot...
Source: Annals of Nuclear Medicine - December 13, 2019 Category: Nuclear Medicine Source Type: research