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FDG-PET biomarkers associated with long-term benefit from first-line immunotherapy in patients with advanced non-small cell lung cancer
ConclusionsIn patients with advanced NSCLC and PD-L1 TPS  ≥ 50%, baseline low TMTV and high tumor SUVmean correlate with survival and LTB from upfront pembrolizumab. Beyond the initial staging, FDG-PET/CT scan could provide relevant biomarkers associated with clinical outcomes that should be taken into account when considering first-line treatment o ptions. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 18, 2020 Category: Nuclear Medicine Source Type: research

Development of a new Python-based cardiac phantom for myocardial SPECT imaging
ConclusionA python-based gated myocardial perfusion SPECT phantom has been successfully developed. The phantom proved to be reliable to assess cardiac software analysis tools in terms of perfusion and functional parameters. The software code is under further development and refinement so that more functionalities and features can be added. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 17, 2020 Category: Nuclear Medicine Source Type: research

Indirectly radioiodinated exendin-4 as an analytical tool for in vivo detection of glucagon-like peptide-1 receptor in a disease setting
ConclusionOur results suggested that [123I]Ex4ipm could be valuable for GLP-1R imaging in diabetes, insulinomas, and various diseases related to GLP-1R. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 16, 2020 Category: Nuclear Medicine Source Type: research

Value of 18 F-FDG PET/CT for prognostic stratification in patients with primary intestinal diffuse large B cell lymphoma treated with an R-CHOP-like regimen
AbstractPurposeThe prognostic value of18F-FDG PET/CT for primary intestinal diffuse large B-cell lymphoma (PI-DLBCL) patients has not been determined. This prompted us to explore the value of18F-FDG PET/CT for prognostic stratification in patients with PI-DLBCL treated with an R-CHOP-like regimen.Materials and methodsSeventy-three PI-DLBCL patients who underwent baseline PET/CT between January 2010 and May 2019 were included in this retrospective study. Total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) were computed using the 41% SUVmax thresholding method. Progression-free survival (PFS) and overall su...
Source: Annals of Nuclear Medicine - October 15, 2020 Category: Nuclear Medicine Source Type: research

Effect of sex on aging-related decline of dopamine transporter in healthy subjects
ConclusionsWe have shown that slopes of regression lines of DAT availabilities and age were significantly different between young and old subjects in females, not in males. Therefore, sex has an impact on aging-related decline of striatal DAT availability. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 14, 2020 Category: Nuclear Medicine Source Type: research

Reactor produced [ 64 Cu]CuCl 2 as a PET radiopharmaceutical for cancer imaging: from radiochemistry laboratory to nuclear medicine clinic
ConclusionsTo the best of our knowledge, this is the first study on use of reactor produced [64Cu]CuCl2 for PET imaging of cancer in human patients. It is envisaged that this route of production of64Cu would aid towards affordable availability of this radioisotope for widespread clinical use in countries with limited cyclotron facilities. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - October 13, 2020 Category: Nuclear Medicine Source Type: research

Immune microenvironment of the gene signature reflecting the standardised uptake value on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography in head and neck squamous cell carcinoma
AbstractObjectiveA comprehensive understanding of the link between18F-FDG PET/CT and the tumor immune microenvironment (TIM) is lacking. We, therefore, investigated the TIM in regard to the gene signature of18F-FDG PET/CT in head and neck squamous cell carcinoma (HNSC).MethodsThe mRNA sequence data of 480 HNSC patients on The Cancer Genome Atlas portal were used to explore genes showing high associations with maximum standardised uptake value (SUVmax) on18F-FDG PET/CT based on Pearson correlation test. Hierarchical clustering of the selected gene signature was performed and divided patients into high and low SUV clusters. ...
Source: Annals of Nuclear Medicine - October 12, 2020 Category: Nuclear Medicine Source Type: research

Comparison of diagnostic accuracy between [ 18 F]FDG PET/MRI and contrast-enhanced MRI in T staging for oral tongue cancer
AbstractObjectiveIntegrated PET/MRI with [18F]FDG is advantageous in that it enables simultaneous PET and MR imaging with higher soft-tissue contrast, multiplanar image acquisition, and functional imaging capability without using fat suppression and gadolinium-based contrast agents (GBCAs). The aims of this study were to demonstrate the feasibility of [18F]FDG PET/MRI for assessing the extent of the primary tumor (T) in oral tongue cancer (OTC) based on the 8th edition of American Joint Committee on Cancer (AJCC) cancer staging system, and to compare the diagnostic accuracy between [18F]FDG PET/MRI and contrast-enhanced MR...
Source: Annals of Nuclear Medicine - October 10, 2020 Category: Nuclear Medicine Source Type: research

Comparison of 18 F-FDG PET/CT and 67 Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan
AbstractObjectiveThe aim of this multicenter prospective study was to compare the sensitivity of18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) with that of67Ga single photon emission computed tomography (SPECT) for the identification of the site of greatest importance for the final diagnosis of the cause of fever of unknown origin (FUO).MethodsThe study participants consisted of patients with an axillary temperature  ≥ 38.0 °C on ≥ 2 occasions within 1 week, with repeated episodes for ≥ 2 weeks prior to providing c...
Source: Annals of Nuclear Medicine - October 9, 2020 Category: Nuclear Medicine Source Type: research

Effects of feeding condition on the myocardial and hepatic accumulation of radioiodine-labeled BMIPP in mice
AbstractObjective123I-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid ([123I]BMIPP), a fatty acid analog, is widely used for the diagnosis of cardiac diseases. Feeding condition is one of the important factors in the myocardial fatty acid uptake, which may also affect myocardial accumulation of [123I]BMIPP and image quality of [123I]BMIPP scintigraphy. However, the relationship between the myocardial accumulation of [123I]BMIPP and the feeding condition is not entirely clear. Therefore, we determined the myocardial accumulation of [125I]BMIPP in mice at various metabolic statuses induced by fasting in comparison with the...
Source: Annals of Nuclear Medicine - October 7, 2020 Category: Nuclear Medicine Source Type: research

Prognostic value of the baseline 18F-FDG PET/CT metabolic tumour volume (MTV) and further stratification in low-intermediate (L-I) and high-intermediate (H-I) risk NCCNIPI subgroup by MTV in DLBCL MTV predict prognosis in DLBCL
ConclusionsMTV, as a tumor metabolic volume parameter, and the NCCNIPI score were independent predictors of prognosis in general DLBCL patients. In the low-intermediate and high-intermediate NCCNIPI subgroup, we further confirm the risk stratification abilities of MTV, which could add the prognostic value of NCCNIPI. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 30, 2020 Category: Nuclear Medicine Source Type: research

Peripheral benzodiazepine receptor/18  kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury
ConclusionsPET signal enhancement by PBR/TSPO at the site of brain injury correlated with the activation of microglia and production of inflammatory cytokines. Furthermore, because FEPPA enables the detection of neurotoxic microglia on PET images, we successfully constructed a novel PET detection system that can monitor neurodegenerative diseases. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 27, 2020 Category: Nuclear Medicine Source Type: research

Effects of upright T-wave in lead aVR on left ventricular volume and function derived from ECG-gated SPECT in patients with advanced chronic kidney disease
AbstractBackgroundNumerous studies have shown the association between chronic kidney disease (CKD) and adverse cardiac events. We investigated whether or not the upright T-wave in lead aVR (TaVR) could predict left ventricular (LV) volume and function derived from ECG-gated SPECT in patients with advanced CKD.MethodsTwo hundred and sixty-one patients with advanced CKD [estimated glomerular filtration rate (eGFR)   0  mV. Enlarged LV end-diastolic volume (LVEDV) was defined as LVEDV index of >  76 ml/m2 in men and  >  57 ml/m2 in women. Reduced LV ejection fraction (LVEF) was de...
Source: Annals of Nuclear Medicine - September 26, 2020 Category: Nuclear Medicine Source Type: research

Quantitative Monte Carlo-based brain dopamine transporter SPECT imaging
ConclusionsReconstruction with full Monte Carlo collimator –detector model yields higher quantitative accuracy than conventional reconstruction. Additional work to reduce the partial volume effect related errors would improve the accuracy further. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 24, 2020 Category: Nuclear Medicine Source Type: research

Bone scintigraphy as a gatekeeper for the detection of bone metastases in patients with prostate cancer: comparison with Ga-68 PSMA PET/CT
ConclusionGa-PSMA is superior to BS for the evaluation of metastatic disease in patients with PCa. However, BS can also detect bone metastases in patients with PCa with a minimum sensitivity of 75%. Biochemical data are helpful to select patients with a high pretest probability who should undergo BS first as a part of the initial workup from an economic point of view. Due to its higher cost, Ga-PSMA PET should be performed in a selective group of patients when BS results are inconclusive or metastasis-directed therapy is planned. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 24, 2020 Category: Nuclear Medicine Source Type: research

Metabolic changes in breast cancer on dual-time-point 18 F-FDG PET/CT imaging according to primary tumor uptake and background parenchymal enhancement
This study was aimed at investigating metabolic changes in breast cancer on dual-time-point18F-FDG PET/CT imaging (DTPI) according to primary tumor uptake and determining whether this technique is affected by background parenchymal enhancement (BPE).MethodsA total of 189 patients with newly diagnosed breast cancer who underwent DTPI examination were retrospectively evaluated. DTPI was performed using a standard FDG/PET protocol followed by delayed image acquisition at 120  min after injection. Patients were divided into two groups according to primary tumor uptake as breast cancer with low maximum standard uptake value (SUVmax) (
Source: Annals of Nuclear Medicine - September 23, 2020 Category: Nuclear Medicine Source Type: research

The utility of a deep learning-based algorithm for bone scintigraphy in patient with prostate cancer
ConclusionsThe software with the deep learning-based algorithm might be used as diagnostic aid in the evaluation of bone metastases for prostate cancer patients. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 20, 2020 Category: Nuclear Medicine Source Type: research

Value of volumetric and textural analysis in predicting the treatment response in patients with locally advanced rectal cancer
AbstractObjectiveThe aim of this study was to assess the value of baseline 18F-FDG PET/CT in predicting the response to neoadjuvant chemo-radiotherapy (NCRT) in patients with locally advanced rectal cancer (LARC) via the volumetric and texture data obtained from 18F-FDG PET/CT images.Methods In total, 110 patients who had undergone NCRT after initial PET/CT and followed by surgical resection were included in this study. Patients were divided into two groups randomly as a train set (n: 88) and test set (n: 22). Pathological response using three-point tumor regression grade (TRG) and me tastatic lymph nodes in PET/CT im...
Source: Annals of Nuclear Medicine - September 18, 2020 Category: Nuclear Medicine Source Type: research

Relapse-free survival after adjuvant radioactive iodine therapy in patients with differentiated thyroid carcinoma with a microscopically positive tumor margin
This study primarily aimed to retrospectively determine the difference in RFS between high-dose (3700 MBq) and low-dose (1110 MBq) adjuvant RAI therapies in DTC patients with a microscopically positive tumor margin. The secondary aim was to investigate the background factors affecting RFS.MethodsForty-eight consecutive patients (15 men and 33 women) who underwent total thyroidectomy between April 2007 and December 2017 for DTC without gross residual tumors and distant metastasis, and who were diagnosed with a positive margin histopathologically, followed by RAI therapy, were enrolled. We retrospectively investiga...
Source: Annals of Nuclear Medicine - September 16, 2020 Category: Nuclear Medicine Source Type: research

Standardization of PET imaging and site qualification program by JSNM: collaboration with EANM/EARL
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 15, 2020 Category: Nuclear Medicine Source Type: research

The contribution of metabolic parameters of FDG PET/CT prior and during therapy of adult patients with lymphomas
AbstractLymphomas are the most common hematological malignancies and are further distinguished in Hodgkin lymphoma (HL) and non-Hodgkin (NHL). For staging purposes and for assessing response to treatment, the Lugano classification is currently used, both for HL and NHL patients, whereas for the assessment of prognosis, several prognostic systems exist, such as the international prognostic index (IPI) and revised-IPI for diffuse large B cell lymphomas, follicular lymphoma IPI (FLIPI)-1 and 2 for follicular lymphomas, and the international prognostic score for advanced HL. The aim of this systematic review was to determine t...
Source: Annals of Nuclear Medicine - September 12, 2020 Category: Nuclear Medicine Source Type: research

Causes of false negatives in technetium-99  m methoxyisobutylisonitrile scintigraphy for hyperparathyroidism: influence of size and cysts in parathyroid lesions
AbstractObjectiveThe aim of this study was to elucidate the causes of false-negative cases of technetium-99  m methoxyisobutylisonitrile scintigraphy (MIBI) for hyperparathyroidism.MethodsConsecutive MIBI examinations performed in 154 patients between April 2011 and March 2017 were retrospectively reviewed. Sensitivities of MIBI, CT and US were calculated. The effects of serum calcium, phosphorus, PTH, weight of parathyroid lesions, use of NSAIDs and Ca-channel blocker (CCB), presence of cyst in parathyroid lesions, and a number of lesions observed by MIBI were investigated.ResultsSeventy-nine patients (21 men and 58 ...
Source: Annals of Nuclear Medicine - September 11, 2020 Category: Nuclear Medicine Source Type: research

Deceased vs. living donor kidney transplantation in prediction of acute renal allograft rejection using Tc-99m DTPA renal scan
ConclusionsAR could be effectively predicted by Tc-99m DTPA renal scan obtained at 1  week post-KT. Different parameters should be applied according to the donor type in the prediction of AR. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 11, 2020 Category: Nuclear Medicine Source Type: research

Recent advances in cardiac positron emission tomography for quantitative perfusion analyses and molecular imaging
AbstractPositron emission tomography (PET) has been used to noninvasively evaluate myocardial perfusion and metabolism. For clinical assessments of myocardial perfusion, the quantitative capability of PET permits precise assessments of ischemia and microcirculatory dysfunction, playing an important role in patient management and outcome analyses.18F-fluorodeoxyglucose (FDG) PET has recently been used to identify active cardiovascular lesions such as cardiac sarcoidosis, endocarditis, and aortitis. This may hold promise for the early and accurate diagnosis of such fatal diseases, as well as for patient management. This revi...
Source: Annals of Nuclear Medicine - September 10, 2020 Category: Nuclear Medicine Source Type: research

Assessment of SPECT-CT fusion images and semi-quantitative evaluation using SUV in 123 I-IMP SPECT in patients with choroidal melanoma
AbstractObjectivesThe aim of this study was to assess the diagnostic ability ofN-isopropyl-p-[I-123] iodoamphetamine (IMP) SPECT semi-quantitative evaluation based on the standardized uptake value (SUV) in patients with choroidal melanoma. The secondary aim was to investigate the 6-h IMP SPECT imaging in comparison with 24-h imaging.MethodsTwenty-five patients (14 males and 11 females, mean age of 59.2-year-old) were analyzed in this retrospective study. Patients underwent 24-h IMP SPECT imaging with a gamma camera after intravenous injection of IMP. Twelve of 25 patients underwent 6-h SPECT imaging in addition to the 24-h...
Source: Annals of Nuclear Medicine - September 8, 2020 Category: Nuclear Medicine Source Type: research

Unilateral sentinel node detection in midline tumors: we should report the “whole truth”
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Source Type: research

Sentinel node biopsy in midline tumors: we should be careful and accurate
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - September 1, 2020 Category: Nuclear Medicine Source Type: research

High-dose 131 I-mIBG as consolidation therapy in pediatric patients with relapsed neuroblastoma and ganglioneuroblastoma: the Japanese experience
ConclusionsConsolidation therapy with high-dose131I-mIBG for patients with 2nd CR showed good overall and progression-free survival. While the risks of radiation exposure must be considered, high-dose131I-mIBG therapy as consolidation therapy needs to be further investigated. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 28, 2020 Category: Nuclear Medicine Source Type: research

The 2020 national diagnostic reference levels for nuclear medicine in Japan
AbstractThe diagnostic reference levels (DRLs) are one of several effective tools for optimizing nuclear medicine examinations and reducing patient exposure. With the advances in imaging technology and alterations of examination protocols, the DRLs must be reviewed periodically. The first DRLs in Japan were established in 2015, and since 5  years have passed, it is time to review and revise the DRLs. We conducted a survey to investigate the administered activities of radiopharmaceuticals and the radiation doses of computed tomography (CT) in hybrid CT accompanied by single photon emission computed tomography (SPECT)/C...
Source: Annals of Nuclear Medicine - August 26, 2020 Category: Nuclear Medicine Source Type: research

Regional gray matter-dedicated SUVR with 3D-MRI detects positive amyloid deposits in equivocal amyloid PET images
ConclusionThe regional GMSUVR measurement method was well able to discriminate between amyloid-positive and -negative subjects, even in cases where amyloid deposition was equivocal. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 26, 2020 Category: Nuclear Medicine Source Type: research

Development of Convolutional Neural Networks to identify bone metastasis for prostate cancer patients in bone scintigraphy
ConclusionsThe prediction results reveal the efficacy of the proposed CNN-based approach and its ability for an easier and more precise interpretation of whole-body images in bone metastasis diagnosis for prostate cancer patients in nuclear medicine. This leads to marked effects on the diagnostic accuracy and decision-making regarding the treatment to be applied. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - August 23, 2020 Category: Nuclear Medicine Source Type: research

Discontinuation of metformin to prevent metformin-induced high colonic FDG uptake: is 48  h sufficient?
AbstractObjectiveIn this retrospective, single-center observational study, we investigated whether discontinuing metformin for at least 48  h prevents metformin-induced [18F]fluorodeoxyglucose (FDG) uptake in all segments of the colon.MethodsPatients with type 2 diabetes who were using metformin before undergoing an FDG PET/CT scan were included. Two groups were created: patients who discontinued metformin for less than 48  h (
Source: Annals of Nuclear Medicine - August 18, 2020 Category: Nuclear Medicine Source Type: research

Evaluation of pleural lesions after pleurodesis with OK-432 by fluorodeoxyglucose-positron emission tomography/CT
This study aimed to determine changes in FDG-PET/CT after pleurodesis with OK-432 and to investigate differences in the changes between non-malignant and malignant lesions.MethodsStudy participants were 17 patients with a history of malignant chest disease who underwent FDG-PET/CT after pleurodesis using OK-432 and in whom pleural lesions were determined to be non-malignant (n = 8) or malignant (n = 9). FDG uptake (SUVmax) was counted on all pleural lesions. CT findings (CT attenuation, shape) of pleural lesions with increased FDG uptake were evaluated.ResultsThe number of patients with increase...
Source: Annals of Nuclear Medicine - August 17, 2020 Category: Nuclear Medicine Source Type: research

Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study
AbstractObjectiveTo examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in subjects with mild cognitive impairment (MCI).MethodsWe collected 23 participants (60 –89 years old, 11 males/12 females) with MCI from the Alzheimer’s Disease Neuroimaging Initiative database. All participants underwent18F flortaucipir (FTP) positron emission tomography (PET) and structural magnetic resonance imaging (MRI) scans at the baseline and follow-up visits (12 –36 months). General linear models with covariates (baseline age, sex) were used to detect brain areas of sig...
Source: Annals of Nuclear Medicine - August 11, 2020 Category: Nuclear Medicine Source Type: research

18 F-choline PET/CT and PET/MRI in primary and recurrent hyperparathyroidism: a systematic review of the literature
AbstractThe aims of the present systematic review were to: (1) assess the role of18F-fluorocholine (FCH) positron emission tomography (PET) with computed tomography (CT) and PET with magnetic resonance imaging (MRI) in patients with biochemically known hyperparathyroidism; (2) compare the diagnostic performance of FCH PET/CT or PET/MRI with conventional morphological and functional imaging. A literature search until December 2019 was performed in the PubMed, Scopus and Web of Science databases, using the terms “choline” AND “PET” AND “hyperparathyroidism”. The search was conducted with a...
Source: Annals of Nuclear Medicine - August 6, 2020 Category: Nuclear Medicine Source Type: research

Role of carbonated water technique to enhance Tc-99m tetrofosmin myocardial perfusion imaging by reducing subdiaphragmatic artefacts
In this study, we endeavoured to determine the effect of carbonated water in reducing such infracardiac artefact so to improve MPI image quality, sensitivity and specificity.MethodsA total of 1000 patients were prospectively enrolled and randomised into two equal groups as A and B. Group A were given 250  ml of carbonated beverages and Group B were given 250 ml plain water immediately after radiotracer injection. Images were evaluated qualitatively and quantitatively for the interfering extracardiac artefacts.ResultsThe qualitative analysis favoured carbonated water in reducing the interfering intestinal activity...
Source: Annals of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Source Type: research

Development of 68 Ga-labeled tin colloids for evaluating phagocytic function of Kupffer cells using preclinical PET imaging
This study aimed to investigate the optimal conditions for producing68Ga-labeled tin colloid and the feasibility of68Ga-tin colloid positron emission tomography (PET) for visualization and evaluation of the phagocytic function of Kupffer cells (KCs) in vivo.Methods68Ga-tin colloid was prepared by adding tin solution (1  mM, 0.2 mL) to68Ga solution (1.0  mL), followed by pH adjustment with sodium acetate (1 M, 0.2 mL). Various labeling times were tested to find the optimal one. Colloid size was measured by filtering the solution through three-ply membrane filters (with pore sizes of 200, 3000, and 5...
Source: Annals of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Source Type: research

SPECT-CT visualization and biopsy of sentinel lymph nodes in patients with stage IAB –IIA cervical cancer
ConclusionsIn women with SPECT-CT visualization of SLNs on both sides of the pelvis, SLN biopsy had high sensitivity and NPV. In patients with unilateral SLN localization, SLN biopsy cannot be used for the prediction of regional LN status. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 14, 2020 Category: Nuclear Medicine Source Type: research

The REICA method for quantification of cerebral blood flow is less affected by lung washout of [ 123 I] IMP than the graph-plot method
This study aims to confirm the reliability of the REICA method in calculating CBF by accounting for pulmonary tracer retention artefact.MethodsData of 100 patients were retrospectively analyzed. Washout rate (WR) was defined as 1- (max count /min count) in the lungs. The bias due to WR was analyzed by dividing the data into high/low WR groups and a multiple regression analysis was also performed.ResultsThe REICA method did not show significant bias according to the$$\chi ^2$$ test ($$p=0.07$$), while the GP method showed significant bias ($$p=0.0006$$). Both the REICA and GP methods showed significant correlation with auto...
Source: Annals of Nuclear Medicine - July 12, 2020 Category: Nuclear Medicine Source Type: research

Sentinel lymph node biopsy in muscle-invasive bladder cancer: single-center experience
ConclusionsSentinel node biopsy is a feasible method for lymph node staging in MIBC, including patients with a history of NAC. To optimize the sensitivity, the decision regarding the lymphadenectomy is best to be based on the pathological status of sentinel node harvested from each hemipelvis separately as the unilateral finding of a sentinel node, does not rule out the possibility of metastatic involvement of contralateral pelvic lymph nodes. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 11, 2020 Category: Nuclear Medicine Source Type: research

The relationship between cholecystokinin secretion and pancreatic [ 11 C]methionine uptake in patients after partial pancreaticoduodenectomy
ConclusionThe association between CCK concentrations and pancreatic [11C]MET uptake might indicate a causal relationship. Further research should assess whether [11C]MET uptake could serve as a less invasive tool to assess exocrine pancreas activity. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 10, 2020 Category: Nuclear Medicine Source Type: research

Validation of the 3-variable prognostic score (3-PS) in mCRPC patients treated with 223 Radium-dichloride: a national multicenter study
ConclusionThis study confirms the validity of the 3-PS score for mCRPC patients. This score is simple, noninvasive and affordable and can be easily used to select patients that will most probably complete223Ra treatment. In addition, this tool provides an exact estimate of life expectancy in terms of OS. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 10, 2020 Category: Nuclear Medicine Source Type: research

Comparison of thyroid hormone withdrawal and recombinant human thyroid-stimulating hormone administration for adjuvant therapy in patients with intermediate- to high-risk differentiated thyroid cancer
AbstractObjectiveTo compare the clinical outcome in patients who received adjuvant therapy with radioactive iodine (RAI) using different preparation methods, namely, thyroid hormone withdrawal (THW) and recombinant human thyroid-stimulating hormone (rhTSH), after undergoing thyroidectomy for intermediate- to high-risk differentiated thyroid carcinoma (DTC) according to the American Thyroid Association criteria.MethodsBetween May 2012 and October 2018, 136 patients who underwent adjuvant therapy with high-dose (3700  MBq) RAI for DTC without any metastatic lesions or macroscopic residual lesions after surgical resectio...
Source: Annals of Nuclear Medicine - July 7, 2020 Category: Nuclear Medicine Source Type: research

Cellular S values in spindle-shaped cells: a dosimetry study on more realistic cell geometries using Geant4-DNA Monte Carlo simulation toolkit
ConclusionsThe findings of the present work suggest that the assumption of spherical cell geometry may provide reasonably accurate estimates of the cellular/nuclear dose for the considered Auger emitters, even for spindle-shaped cells. Of course, this approximation should be used with caution for the nucleus  ← cytoplasm and nucleus ← cell surface configurations, since theS-value sensitivity to the cell geometry is somewhat significant in these cases. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 5, 2020 Category: Nuclear Medicine Source Type: research

Visualization of translocator protein (18  kDa) (TSPO) in the retina of diabetic retinopathy rats using fluorine-18-DPA-714
AbstractObjectivesTo investigate the feasibility of a noninvasive method for imaging translocator protein (18  kDa) (TSPO) in the retina of diabetic retinopathy (DR) rats using fluorine-18-DPA-714 ([18F]-DPA-714) micro-positron emission tomography (PET)/X-ray computed tomography (CT).MethodsSprague –Dawley (SD) rats were intraperitoneally injected with streptozocin (STZ) (65 mg kg−1, ip) to induce diabetes mellitus (DM). The TSPO in both eyes was detected by PET/CT using [18F]-DPA-714 12  weeks after the establishment of the DM model. The mean standardized uptake value (SUVmean) was analyzed...
Source: Annals of Nuclear Medicine - July 5, 2020 Category: Nuclear Medicine Source Type: research

Detection of sub-centimeter lesions using digital TOF-PET/CT system combined with Bayesian penalized likelihood reconstruction algorithm
ConclusionThe BPL in the digital TOF-PET/CT scanner improved the quantitation and detectability of sub-centimeter spheres compared with OSEM-based reconstruction. Optimization of theβ value in BPL might allow the detection of lesions  ≤ 6 mm, although detectability depended on the TBR of lesions. Aβ value of 200 seemed optimal for detecting sub-centimeter lesions. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 3, 2020 Category: Nuclear Medicine Source Type: research

Evaluating and comparing the image quality and quantification accuracy of SiPM-PET/CT and PMT-PET/CT
ConclusionSiPM-PET/CT provides superior image quality and quantification accuracy compared to PMT-PET/CT. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 2, 2020 Category: Nuclear Medicine Source Type: research

A method to measure the extent of myocardial ischemia and steal with SPECT myocardial blood flow quantitation
AbstractObjectiveWe introduced a method to measure the extent of myocardial ischemia and steal with SPECT MBF quantitation.MethodsEighty-seven patients who received rest/Dipyridamole-stress99mTc-Sestamibi (MIBI) dynamic SPECT scans and coronary angiography were included. Dynamic SPECT images were reconstructed with full physical corrections. The one-tissue kinetic model was utilized to quantify K1 and further converted to MBF with required corrections. Rest MBF, stress MBF and myocardial flow reserve (MFR) were converted to a flow status polar map by a flow diagram. Extents of 7 flow statuses were verified their cutoff poi...
Source: Annals of Nuclear Medicine - June 29, 2020 Category: Nuclear Medicine Source Type: research

Clinical impact of 68 Ga-DOTATATE PET-CT imaging in patients with medullary thyroid cancer
Conclusion68 Ga-DOTATATE is an essential part of the work-up for patients with MTC. This modality outperformed CI in 14/38 (37%) patients and changed the clinical management in 13/38 (34%) patients. Prospective randomized studies with image-guided therapy decisions are needed to further reveal the impact of PE T imaging in patients with MTC. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - June 28, 2020 Category: Nuclear Medicine Source Type: research

Diagnostic performance of whole-body bone scintigraphy in combination with SPECT/CT for detection of bone metastases
AbstractObjectiveThis retrospective study investigated the performance of whole-body bone scintigraphy combined with SPECT/CT and established a grading diagnostic criterion for bone metastases.MethodsWe summarized signs of whole-body bone imaging combined with SPECT in nuclear medicine and CT signs of corresponding parts. Then we established a diagnostic criterion for bone metastases by using whole-body bone scintigraphy combined with local SPECT/CT. The criterion is classified into five grades. 120 patients with a total of 141 lesions underwent whole-body bone scintigraphy and SPECT/CT. Two reviewers read the images accor...
Source: Annals of Nuclear Medicine - June 23, 2020 Category: Nuclear Medicine Source Type: research