High detection rate in [ 18 F]PSMA-1007 PET: interim results focusing on biochemical recurrence in prostate cancer patients
Conclusions[18F]PSMA-1007 PET showed a high detection rate in recurrent and metastatic lesions. In patients with BCR, its high detection led to suitable treatment strategies, such as salvage radiation therapy or surgical removal of recurrent lymph nodes.Trial registration(UMIN Clinical Trials Registry) UMIN000037697. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 4, 2021 Category: Nuclear Medicine Source Type: research

Association between PD-L1 expression and 18 F-FDG uptake in ovarian cancer
ConclusionThere was a significant correlation between18F-FDG uptake and PD-L1 expression, suggesting a role of18F-FDG PET/CT in selecting ovarian cancer candidates for anti-PD-L1 antibody therapy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 3, 2021 Category: Nuclear Medicine Source Type: research

Phase I clinical study of NMB58, a novel positron emission tomography (PET)-myocardial perfusion imaging tracer, conducted to evaluate its safety and pharmacokinetics in Japanese healthy adult males
ConclusionsBased on radiation dosimetry, biodistribution, and safety evaluations, NMB58 was found to be a suitable tracer for clinical use in PET myocardial perfusion imaging during exercise or pharmacological stress. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 1, 2021 Category: Nuclear Medicine Source Type: research

A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single-photon emission computed tomography
AbstractObjectiveDopamine transporter single-photon emission computed tomography (DAT SPECT) has been widely used to diagnose Parkinson syndrome. Using the standardized uptake value (SUV) of DAT SPECT, we propose “functional dopamine transporter volume (f-DTV)” as a new quantitative index to evaluate the three-dimensional volume of functional dopamine transporters and assess its diagnostic ability in differentiating dopaminergic neurodegenerative diseases (dNDD) from non-dNDD.MethodsSeventy-nine patients were enrolled (42 dNDD, 37 non-dNDD; 38 men; age 24 –88 years). We analyzed seven quantitative in...
Source: Annals of Nuclear Medicine - February 25, 2021 Category: Nuclear Medicine Source Type: research

Predictive factors of tumor sink effect: Insights from 177 Lu-Prostate-specific membrane antigen therapy
In this study, we have investigated the predictive factors of the tumor sink effect in a group of patients who received177Lu-Prostate-specific membrane antigen (PSMA) therapy due to progressive metastatic castration-resistant prostate cancer (mCRPC).MethodsWe have retrospectively analyzed the pre-therapy68Ga-PSMA positron-emission tomography (PET)-computed tomography (CT) and post-therapy planar whole-body scans of 65 patients who received at least two cycles of 7.4  GBq of177Lu-PSMA therapy. All patients with mCRPC were referred to our department after multiple treatment lines. Age, previous therapies, International ...
Source: Annals of Nuclear Medicine - February 14, 2021 Category: Nuclear Medicine Source Type: research

123 I metaiodobenzylguanidine (MIBG) uptake predicts early relapse of neuroblastoma using semi-quantitative SPECT/CT analysis
AbstractObjective123I metaiodobenzylguanidine (MIBG) scintigraphy is a useful tool for the diagnosis of neuroblastoma (NB). MIBG uptake is correlated with norepinephrine transporter expression; hence, it is expected that high-MIBG tumors would be more highly differentiated and have a better prognosis than those with lower expression. We have introduced a method of assessing MIBG accumulation semi-quantitatively using SPECT/CT fusion images. The purpose of this study was to evaluate the relationship of123I MIBG uptake measured by semi-quantitative values of SPECT/CT and early relapse of NB.MethodsWe studied the cases of 11 ...
Source: Annals of Nuclear Medicine - February 14, 2021 Category: Nuclear Medicine Source Type: research

Correlations between whole body volumetric parameters of 68 Ga-PSMA PET/CT and biochemical-histopathological parameters in castration-naive and resistant prostate cancer patients
ConclusionsWbv68Ga-PSMA PET/CT results were correlated with PSA levels and Gleason scores. The correlation was relatively stronger in the castration-naive group. The prognostic accuracy of PSA in the resistant group may be weaker than in the naive group. The difference in volumetric parameters of patients with short BR compared to long BR supports the idea that68Ga-PSMA PET/CT can distinguish patients with rapid relapse from others. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 14, 2021 Category: Nuclear Medicine Source Type: research

Potential of three-step pretargeting radioimmunotherapy using biotinylated bevacizumab and succinylated streptavidin in triple-negative breast cancer xenograft
This study performed three-step (3-step) PRIT using the sequential injection of (1) biotinylated bevacizumab (Bt-BV), (2) avidin, and (3) radiolabeled StAv for the treatment of triple-negative breast cancer (TNBC).MethodsFour biodistribution studies were performed using111In in tumor-bearing mice to optimize each step of our PRIT methods. Further, a therapeutic study was performed with optimized 3-step PRIT using90Y-labeled StAv.ResultsBased on the biodistribution studies, the protein dose of Bt-BV and avidin was optimized to 100  μg and 10 molar equivalent of BV, respectively. Succinylation of StAv significantly d...
Source: Annals of Nuclear Medicine - February 13, 2021 Category: Nuclear Medicine Source Type: research

Diagnostic performance of 68 Ga-DOTATOC PET/CT in tumor-induced osteomalacia
Conclusions68Ga-DOTATOC PET/CT was clinically useful in detecting culprit tumors and subsequent patient management in TIO. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 13, 2021 Category: Nuclear Medicine Source Type: research

Prognostic value of 18F-FDG PET/MRI in patients with advanced oropharyngeal and hypopharyngeal squamous cell carcinoma
AbstractObjectiveThe aim of this study was to evaluate the prognostic value of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI in patients with locally advanced oropharyngeal and hypopharyngeal squamous cell carcinomas (OHSCC).MethodsForty-five patients with locally advanced OHSCC who underwent simultaneous FDG PET/MRI before (chemo)radiotherapy were retrospectively enrolled. Peak standardized uptake value (SULpeak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary lesion were obtained on PET d...
Source: Annals of Nuclear Medicine - February 11, 2021 Category: Nuclear Medicine Source Type: research

Acknowledgements to Reviewers
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 10, 2021 Category: Nuclear Medicine Source Type: research

Prognostic value of tumor metabolic imaging phenotype by FDG PET radiomics in HNSCC
This study was performed to assess the prognostic value of radiomics PET parameters in head and neck squamous cell carcinoma (HNSCC) patients.Methods18F-fluoro-deoxy-glucose (FDG) PET/CT data of 215 patients from HNSCC collection free database in The Cancer Imaging Archive (TCIA), and 122 patients in Seoul St. Mary ’s Hospital with baseline FDG PET/CT for locally advanced HNSCC were reviewed. Data from TCIA database were used as a training cohort, and data from Seoul St. Mary’s Hospital as a validation cohort. With the training cohort, primary tumors were segmented by Nestles’ adaptive thresholding metho ...
Source: Annals of Nuclear Medicine - February 8, 2021 Category: Nuclear Medicine Source Type: research

Semi-quantitative assessment optimized the grading of pulmonary aspiration on salivagram in children
This study aims to optimize the classification of pulmonary aspiration detected by salivagram with a semi-quantitative analytical method.MethodsThis is a retrospective study involving 737 patients (471 males, 266 females; aged 1  month to 8 years; mean age 5.3 months, median age 3.0 months old) with suspected pulmonary aspiration, who had salivagram done between January 2018 and June 2019. Positive cases were divided into 10 groups (Grade 1, R2, L2, R2L2, R3, L3, R3L2, R2L3, R3L3, and 4) according to the scintigraphic f indings. Aspiration index was determined as the ratio of the count in the respirator...
Source: Annals of Nuclear Medicine - February 8, 2021 Category: Nuclear Medicine Source Type: research

Digital PET/CT allows for shorter acquisition protocols or reduced radiopharmaceutical dose in [ 18 F]-FDG PET/CT
AbstractPurposeTo establish the feasibility of shorter acquisition times (and by analogy, applied activity) on tumour detection and lesion contrast in digital PET/CT.MethodsTwenty-one randomly selected patients who underwent oncological [18F]-FDG PET/CT on a digital PET/CT were retrospectively evaluated. Scan data were anonymously obtained and reconstructed in list-mode acquisition for a standard 2  min/bed position (bp), 1 min/bp and 30 s/bp (100%, 50% and 25% time or applied activity, respectively). Scans were randomized and read by two nuclear medicine physicians in a consensus read. Readers were blind to...
Source: Annals of Nuclear Medicine - February 7, 2021 Category: Nuclear Medicine Source Type: research

Diagnostic value of [ 18 F]Fluorocholine PET/CT in detection of primary medullary thyroid cancer
AbstractObjectiveMedullary thyroid cancer (MTC) is a challenging neuroendocrine malignancy where the role of nuclear medicine imaging is currently limited. This paper investigates the potential diagnostic value of [18F]Fluorocholine PET/CT in primary MTC.MethodsWe prospectively enrolled 25 patients (10 male, 15 female) with suspicion for primary MTC based on fine-needle aspiration biopsy (FNAB). All patients had a baseline three phase [18F]Fluorocholine PET/CT (2.5  MBq/kg): two regional head and neck and upper mediastinum studies at 5 min (first phase) and 120 min (third phase) and a whole-body PET/CT (from...
Source: Annals of Nuclear Medicine - February 5, 2021 Category: Nuclear Medicine Source Type: research

Prediction of local recurrence and distant metastasis using radiomics analysis of pretreatment nasopharyngeal [18F]FDG PET/CT images
AbstractObjectivesTo develop a radiomics signature to predict locoregional recurrence (LR) and distant metastasis (DM), as extracted from pretreatment 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) positron emission tomography/X-ray computed tomography (PET/CT) images in locally advanced nasopharyngeal carcinoma (NPC).Materials and methodsEighty-five patients with Stage III –IVB NPC underwent pretreatment [18F]FDG PET/CT scans and received radiotherapy or chemoradiotherapy. 53 of them achieved disease control, and 32 of them failed after treatment (15: LR, 17: DM). A total of 114 radiomic features were extracted from PET...
Source: Annals of Nuclear Medicine - February 4, 2021 Category: Nuclear Medicine Source Type: research

Role of traditional CHO PET parameters in distinguishing IDH, TERT and MGMT alterations in primary diffuse gliomas
ConclusionsTraditional CHO PET parameters are capable of distinguishing IDH but not TERT or MGMT alterations in the whole population. In accordance with the clinical understanding of TERT promoter mutations, the T/N ratio and TLC can also discriminate the TERT status in IDH subgroups. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 2, 2021 Category: Nuclear Medicine Source Type: research

[18F]FDG PET/MRI in rectal cancer
AbstractWe conducted a systematic literature review on the use of [18F]FDG PET/MRI for staging/restaging rectal cancer patients with PubMed, Scopus, and Web of Science, based on the PRISMA criteria. Three authors screened all titles and abstracts and examined the full texts of all the identified  relevant articles. Studies containing aggregated or duplicated data, review articles, case reports, editorials, and letters were excluded. Ten reports met the inclusion criteria. Four studies examined T staging and one focused on local recurrences after surgery; the reported sensitivity (94–100% ), specificity (73&ndash...
Source: Annals of Nuclear Medicine - January 31, 2021 Category: Nuclear Medicine Source Type: research

Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen
ConclusionsUsing PET/MRI with oxygen-15 labeled gases, CBF, CBV, OEF, and CMRO2 could be measured. Values of CBF, CBV, and CMRO2 measured with attenuation correction by DIXON were significantly lower than those measured with correction by DIXONbone. One of the reasons for this is that attenuation correction of DIXON does not take into consideration of the photon absorption by bone. OEF values, corresponding to ratios of CMRO2 to CBF, were not affected by attenuation correction methods. Values of CBF and CMRO2 with a real-time motion correction were significantly higher than those without correction. Using PET/MRI with adeq...
Source: Annals of Nuclear Medicine - January 27, 2021 Category: Nuclear Medicine Source Type: research

Clinical practice guidelines for high-resolution breast PET, 2019 edition
This article updates readers as to what is new in the second edition. This edition supports two different types of breast PET depending on the placement of the detector: the opposite-type (positron emission mammography; PEM) and the ring-shaped type (dedicated breast PET; dbPET), providing an overview of these scanners and appropriate imaging methods, their clinical applications, and future prospects. The name “dedicated breast PET” from the first edition is widely used to refer to ring-shaped type breast PET. In this edition, “breast PET” has been defined as a term that refers to both opposite- and...
Source: Annals of Nuclear Medicine - January 25, 2021 Category: Nuclear Medicine Source Type: research

11 C-Methionine PET/CT in patients with primary hyperparathyroidism and inconclusive pre-operative imaging work-up: diagnostic accuracy and role of semi-quantitative analysis
AbstractObjective11C-Methionine PET/CT (C-MET) is a promising method in detecting abnormal parathyroid glands in patients with primary hyperparathyroidism (PHPT). The first aim of the study was to evaluate which is the diagnostic role of C-MET in patients with PHPT and inconclusive pre-operative imaging. Second, we aimed to investigate whether C-MET semi-quantitative parameters may reflect biochemical and histological characteristics of involved glands.MethodsPatients with PHPT, undergoing C-MET after an inconclusive pre-operative imaging and having a parathyroid surgery, were retrospectively included. C-MET visual and sem...
Source: Annals of Nuclear Medicine - January 24, 2021 Category: Nuclear Medicine Source Type: research

Prognostic and predictive values of interim 18 F-FDG PET during neoadjuvant chemoradiotherapy for esophageal cancer: a systematic review and meta-analysis
ConclusionChange in SUV on interim18F-FDG PET had significant prognostic value and moderate predictive value for a pathologic response in esophageal cancer treated with neoadjuvant chemoradiotherapy. Interim18F-FDG PET may help prognostic stratification and guide treatment planning in oncologic practice. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 20, 2021 Category: Nuclear Medicine Source Type: research

Clinical value of machine learning-based interpretation of I-123 FP-CIT scans to detect Parkinson ’s disease: a two-center study
ConclusionML-based interpretation of I-123-FP-CIT scans results in accurate discrimination of PD from non-PD similar to visual assessment in both centers. The derived SVM model is therefore generalizable towards centers using comparable acquisition and image processing methods and implementation as diagnostic aid in clinical practice is encouraged. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 20, 2021 Category: Nuclear Medicine Source Type: research

Prognosis predicting value of semiquantitative parameters of visceral adipose tissue and subcutaneous adipose tissue of 18 F-FDG PET/CT in newly diagnosed secondary hemophagocytic lymphohistiocytosis
ConclusionsFor newly diagnosed SHLH, SAT Volume, SUVmean of SAT, plasma EBV-DNA had significant relationship with poor prognosis. They were important independent predictors for overall survival for newly diagnosed SHLH. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 19, 2021 Category: Nuclear Medicine Source Type: research

Development and characterization of an all-in-one gamma probe with auto-peak detection for sentinel lymph node biopsy based on NEMA NU3-2004 standard
ConclusionThe performance characterization showed that GammaPen can be used effectively for sentinel lymph node localization. The probe was successfully used in several surgical interventions by an experienced surgeon confirming its suitability in a clinical setting. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 19, 2021 Category: Nuclear Medicine Source Type: research

Radioactive synthesis of tau PET imaging agent 18 F-AV-1451 and its role in monitoring the progression of Alzheimer ’s disease and supporting differential diagnosis
AbstractAlzheimer ’s disease (AD) is on the rise all over the world, and brings with it great challenges to medical care and heavy burdens to family and society. Accurate diagnosis and differential diagnosis are of great importance. Tau positron emission tomography (PET) might offer novel insights and be of great a ssistance in monitoring disease progression and supporting the differential diagnosis.18F-AV-1451, as the first Tau PET imaging agent approved by the Food and Drug Administration (FDA), has been of great potential in clinical trials. Here, we reviewed the synthesis and characteristics of18F-AV-1451 and its...
Source: Annals of Nuclear Medicine - January 18, 2021 Category: Nuclear Medicine Source Type: research

Metal artifact reduction for improving quantitative SPECT/CT imaging
ConclusionsThis study indicated that iMAR could improve the quantitative accuracy of SPECT/CT independent of the CT dose. iMAR can serve as a practicable technique for quantitative SPECT/CT in patients with metal implants. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 18, 2021 Category: Nuclear Medicine Source Type: research

[ 18 F]FDG PET/MRI versus contrast-enhanced MRI in detecting regional HNSCC metastases
AbstractObjectiveTo compare the accuracy of contrast-enhanced MRI using established dimensional and morphological criteria versus integrated [18F]FDG PET/MRI in identifying regional lymph node metastases in patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC). For this purpose, we compare MRI and PET/MRI using the histopathological findings in dissected lymph nodes as the gold standard.MethodsWe retrospectively reviewed 26 patients with histologically proven HNSCC who underwent gadolinium-enhanced [18F]FDG PET/MRI as part of their staging. All neck lymph nodes were classified on MRI using dimensional...
Source: Annals of Nuclear Medicine - January 17, 2021 Category: Nuclear Medicine Source Type: research

The impact of data-driven respiratory gating in clinical F-18 FDG PET/CT: comparison of free breathing and deep-expiration breath-hold CT protocol
AbstractBackgroundRespiratory motion can diminish PET image quality and lead to inaccurate lesion quantifications. Data-driven gating (DDG) was recently introduced as an effective respiratory gating technique for PET. In the current study, we investigated the clinical impact of DDG on respiratory movement in18F-FDG PET/CT.MethodPET list-mode data were collected for each subject and DDG software was utilized for extracting respiratory waveforms. PET images was reconstructed using Q.clear and Q.clear  + DDG, respectively. We evaluated SUVmax, SUVmean, the coefficient of variance (CoV), metabolic tumor volume (M...
Source: Annals of Nuclear Medicine - January 15, 2021 Category: Nuclear Medicine Source Type: research

Oncologic significance of unexpected osseous foci on FDG-PET without correlative CT abnormalities
This study is a retrospective review of 120 osseous FWCT, reported in 91 patients, and their corresponding clinical follow-up. We included only patients with at least 6  months of clinical follow-up leading to a final diagnosis, reviewing bone biopsy results, follow-up imaging, and clinical notes. We excluded those patients on active chemotherapy at the time of the scan. For reports describing >  3 foci, we only analyzed the one with highest maximum standardized uptake value (SUVmax). As a measure of uptake intensity, we obtained focus-to-liver ratios (F/L) utilizing their SUVmax and corresponding hep...
Source: Annals of Nuclear Medicine - January 13, 2021 Category: Nuclear Medicine Source Type: research

Synthesis and evaluation of gallium-68-labeled nitroimidazole-based imaging probes for PET diagnosis of tumor hypoxia
ConclusionsOur study suggested that the length of the linkers connecting nitroimidazole to a bifunctional chelate affect PET imaging of hypoxic tumors with68Ga-radiolabeled compounds. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 9, 2021 Category: Nuclear Medicine Source Type: research

In vitro and in vivo evaluation of [ 125/123 I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol([ 125/123 I]-OI5V) as a potential sigma-1 receptor ligand for SPECT
ConclusionsThis study confirmed that [125/123I]OI5V selectively binds σ-1R in the rat brain in vivo. [123I]OI5V was suggested to be useful as a σ-1R ligand for SPECT. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 8, 2021 Category: Nuclear Medicine Source Type: research

Somatostatin receptor-positive breast lesions on 68 Ga-DOTATATE PET/CT
ConclusionSSTR  + breast lesions on DOTA PET are rarely seen in clinical practice. Uptakes of breast lesions in our cases were variable and not useful for differential diagnosis of lesions. It seems that SSTR + breast lesions should be evaluated with clinical and radiological characteristics, and correlati ve breast imaging and/or histopathological verification should be performed for suspicious lesions to avoid misdiagnosis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 5, 2021 Category: Nuclear Medicine Source Type: research

An overview of the developments and potential applications of 68 Ga-labelled PET/CT hypoxia imaging
AbstractNon-invasive imaging of hypoxia plays a role in monitoring the body ’s adaptive response or the development of pathology under hypoxic conditions. Various techniques to image hypoxia have been investigated with a shift towards the use of molecular imaging using PET/CT. The role of hypoxia-specific radiopharmaceuticals such as radiolabelled nitroimidazoles is well documented particularly in the oncologic setting. With the increasing utilisation of in-house labelling with a PET benchtop generator, such as the68Ge/68Ga generator, the use of68Ga-labelled hypoxic radiopharmaceuticals in the clinical setting is dev...
Source: Annals of Nuclear Medicine - January 5, 2021 Category: Nuclear Medicine Source Type: research

Test –retest repeatability of quantitative bone SPECT/CT
ConclusionAn almost perfect correlation was demonstrated by repeated SUVmax and SUVpeak measured by quantitative integrated SPECT/CT. The quantitative values could be reliable indicators in patient management. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 5, 2021 Category: Nuclear Medicine Source Type: research

Comparison of Alzheimer ’s disease patients and healthy controls in the easy Z-score imaging system with differential image reconstruction methods using SPECT/CT: verification using normal database of our institution
ConclusionWith the99mTc-ECD SPECT, the eZIS analysis equipped with our institutional AD-specific VOI and NDB using OSEM image reconstruction could distinguish HC from AD better than eZIS analysis using FBP image reconstruction.This study is registered in UMIN Clinical Trials Registry (UMIN-CTR) as UMIN study ID: UMIN000042362. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 4, 2021 Category: Nuclear Medicine Source Type: research

Cardiovascular event risk estimated after coronary revascularization and optimal medical therapy: J-ACCESS4 prognostic study
ConclusionsA reduction in cardiac ischemia and an increase in LVEF by revascularization and/or OMT were necessary to avoid cardiac events among patients with moderate-to-high estimated risk, and changes in event risk were quantifiable. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 3, 2021 Category: Nuclear Medicine Source Type: research

Applying postoperative radioiodine therapy before 3  months seems to decrease ablation success in patients with differentiated thyroid carcinoma
ConclusionInvestigated the effect of radioiodine therapy initiated before 3  months after total thyroidectomy and it seems to decrease ablation success. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 3, 2021 Category: Nuclear Medicine Source Type: research

Colchicine treatment early after infarction attenuates myocardial inflammatory response demonstrated by 14 C-methionine imaging and subsequent ventricular remodeling by quantitative gated SPECT
AbstractObjectiveColchicine has been used as an anti-inflammatory agent and may be cardioprotective after acute myocardial infarction (AMI). We investigated how colchicine administration after AMI affects the myocardial inflammatory response using14C-methionine and subsequent ventricular remodeling using single-photon emission computed tomography (SPECT) in a rat model of AMI.MethodsThe left coronary artery (LCA) was occluded for 30  min followed by reperfusion.14C-methionine was injected at 20  min before sacrifice. The LCA was re-occluded at 1 min before sacrifice and99mTc-methoxyisobutylisonitrile (99mTc-...
Source: Annals of Nuclear Medicine - January 3, 2021 Category: Nuclear Medicine Source Type: research

The feasibility of anterior 180 ° 99m Tc-sestamibi parathyroid SPECT/CT
AbstractObjectiveFor99mTc-sestamibi parathyroid single photon emission computed tomography/computed tomography (SPECT/CT), the traditional full-arc 360 ° acquisition technique has been suggested but not the theoretically low tissue-attenuated anterior 180° method. We aimed to compare the diagnostic performances and target-to-background ratios of anterior 180° and 360° SPECT/CT imaging.MethodsNinety-nine patients who underwent99mTc-sestamibi scintigraphy and received a surgical –pathological diagnosis of parathyroid adenoma or hyperplasia were enrolled. The SPECT/CT reconstructed images with anterior 1...
Source: Annals of Nuclear Medicine - January 3, 2021 Category: Nuclear Medicine Source Type: research

Knee radiosynovectomy with 153 Sm-hydroxyapatite compared to 90 Y-hydroxyapatite: initial results of a prospective trial
ConclusionKnee radiosynovectomy with153Sm-HyA is safe, reduces hemarthrosis episodes after 12  months of treatments, especially in adults/adolescents and even with grades III/IV arthropathy, similar to90Y-HyA.90Y-HyA seems to promote better hemarthrosis control in small children. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 2, 2021 Category: Nuclear Medicine Source Type: research

Test –retest reproducibility of dopamine transporter density measured with [ 18 F]FP-CIT PET in patients with essential tremor and Parkinson’s disease
Conclusion[18F]FP-CIT PET is reproducible for the quantitative measurement of DAT binding in both ET and PD individuals, independent of the acquisition time or analysis method. Also, the automatic  method is more suitable for evaluating early loss of DAT binding in patients with PD (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 2, 2021 Category: Nuclear Medicine Source Type: research

Clinical value of PET/CT with carbon-11 4DST in the evaluation of malignant and benign lung tumors
AbstractObjectivesThe aim of this study was to assess the clinical value of [11C]4DST uptake in patients with lung nodules, including benign and malignant tumors, and to assess the correlation between [11C]4DST uptake and proliferative activity of tumors in comparison with [18F]FDG uptake.MethodsTwenty-six patients (22 males and 4 females, mean age of 65.5-year-old) were analyzed in this prospective study. Patients underwent [11C]4DST and [18F]FDG PET/CT imaging on the same day. Diagnosis of each lung nodule was confirmed by histopathological examination of tissue specimens at surgery, or during clinical follow-up after th...
Source: Annals of Nuclear Medicine - January 2, 2021 Category: Nuclear Medicine Source Type: research

Associations of physiologic myocardial 18 F-FDG uptake with fasting duration, HbA1c, and regular exercise
AbstractObjectiveThe variability of physiologic18F-FDG uptake in the myocardium has hampered the accurate evaluation of cardiac glucose metabolism. We investigated the effects of multiple factors, including fasting duration and physical activity, on the physiologic uptake of18F-FDG by the myocardium in healthy participants.MethodsA total of 446 participants (predominantly male, 91%) in a health screening program were included in this retrospective study. For the visual analysis of myocardial18F-FDG uptake, the participants were categorized into three groups according to qualitative visual scales (QVS). For the quantitative...
Source: Annals of Nuclear Medicine - January 2, 2021 Category: Nuclear Medicine Source Type: research

The relationship between the quantitative evaluation of thyroid bed uptake and the disappearance of accumulation in adjuvant radioactive iodine therapy for differentiated thyroid cancer
ConclusionsThe quantitative evaluation might be useful as one of the predictive indicators of the disappearance of the accumulation of radioactive iodine in the thyroid bed. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - January 2, 2021 Category: Nuclear Medicine Source Type: research

Semi-quantification of renal perfusion using 99m Tc-DTPA in systolic heart failure: a feasibility study
AbstractBackgroundRenal scintigraphy with99mTc-diethylenetriaminepentaacetic acid (DTPA) may be used to study renal perfusion (RP) in heart failure (HF) patients. The goal of this study was to establish a new method to assess RP in patients with systolic HF.MethodsIn this retrospective, single-center, observational study, 86 subjects with left ventricular ejection fraction  ≤ 45% and 31 age-matched subjects without HF underwent renal scintigraphy with99mTc-DTPA. Patients with HF were classified into two categories according to the New York Heart Association (NYHA) functional class, i.e., moderate HF with N...
Source: Annals of Nuclear Medicine - January 1, 2021 Category: Nuclear Medicine Source Type: research

Explorative analysis of a score predicting the therapy response of patients with metastatic, castration resistant prostate cancer undergoing radioligand therapy with 177 Lu-labeled prostate-specific membrane antigen
AbstractObjectiveUp to 60% of patients with metastatic, castration-resistant prostate cancer (mCRPC) treated with177Lu prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) achieves a partial biochemical response with a decrease of  >  50% in prostate-specific antigen (PSA) levels. The remaining fractions, however, do not respond to RLT. The aim of this explorative analysis was to identify pre-therapeutic factors for the prediction of response.Methods46 patients [age  = 68 years (50–87)] with mCRPC who consecutively underwent RLT with177Lu PSMA [median applied activit...
Source: Annals of Nuclear Medicine - December 22, 2020 Category: Nuclear Medicine Source Type: research

Non-local mean denoising using multiple PET reconstructions
AbstractObjectivesNon-local mean (NLM) filtering has been broadly used for denoising of natural and medical images. The NLM filter relies on the redundant information, in the form of repeated patterns/textures, in the target image to discriminate the underlying structures/signals from noise. In PET (or SPECT) imaging, the raw data could be reconstructed using different parameters and settings, leading to different representations of the target image, which contain highly similar structures/signals to the target image contaminated with different noise levels (or properties). In this light, multiple-reconstruction NLM filter...
Source: Annals of Nuclear Medicine - November 26, 2020 Category: Nuclear Medicine Source Type: research

Absorbed dose simulation of meta - 211 At-astato-benzylguanidine using pharmacokinetics of 131 I-MIBG and a novel dose conversion method, RAP
ConclusionsThe present RAP dose conversion method could estimate211At-MABG absorbed doses from the pharmacokinetics of131I-MIBG with some limitations. The RAP method would be applicable to a large number of subjects for targeted nuclide therapy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - November 22, 2020 Category: Nuclear Medicine Source Type: research

Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for 99m Tc imaging
ConclusionThe ALBIRA II preclinical SPECT sub-system S102 has a favorable sensitivity and spatial resolution for the 80  mm FOV setting for both the SPH and MPH configurations and is a valuable tool for small animal imaging. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - November 12, 2020 Category: Nuclear Medicine Source Type: research