Clinical utility of SPECT/CT and CT-dacryocystography-enhanced dacryoscintigraphy in the imaging of lacrimal drainage system obstruction
ConclusionsAlthough DSG is a sensitive nuclear medicine method, it only provides useful clinical data when simultaneously supplemented with SPECT/CT and CT-DCG trials as they jointly can offer valuable information about the localization of an abnormality and verify stenosis or obstruction. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 16, 2019 Category: Nuclear Medicine Source Type: research

No delayed imaging or CCK administration is needed in most cases when bowel excretion does not occur but gallbladder fills promptly
ConclusionsWhen a HIDA scan shows p-GB-no-SB, the probability of identifying clinically relevant CBD obstruction by additional imaging with CCK or DI is virtually zero in an acute clinical setting if clearance of liver parenchymal activity is prompt. Additional imaging with CCK or DI can be reserved for only those showing abnormal clearance of liver parenchymal activity. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - July 11, 2019 Category: Nuclear Medicine Source Type: research

Al 18 F-labeled alpha-melanocyte-stimulating hormone ( α-MSH) peptide derivative for the early detection of melanoma
AbstractObjectiveEarly detection plays a role in the prognosis of melanoma, the most aggressive skin cancer.64Cu- and68Ga-labeled alpha-melanocyte-stimulating hormone ( α-MSH) analogs targeting the melanocortin-1 receptor are promising positron emission tomography (PET) tracers for detecting melanoma, and the use of18F-labeling will further contribute to the detectability and availability. However, the high radiochemistry demand related to the conventional18F-labeling methods has restricted the development of18F-labeled α-MSH analogs. A recently developed radiofluorination method using aluminum-fluoride (Al18F)...
Source: Annals of Nuclear Medicine - July 5, 2019 Category: Nuclear Medicine Source Type: research

18F-FDG PET/CT in visceral leishmaniasis: uptake patterns in the context of a multiannual outbreak in Northern Italy
ConclusionsPET/CT demonstrated splenic FDG uptake in all immunocompetent VL pts; two splenic patterns (diffuse/focal over diffuse) were observed and indistinguishable from splenic involvement by other disorders. The most frequent extra-splenic FDG-positive sites were BM and lymph nodes. Considering the potential disease aggressiveness and recent outbreaks in north-eastern Italy, VL should be considered in the differential diagnosis of FDG-positive splenic findings in pts from endemic areas or reporting travels to endemic countries. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - June 28, 2019 Category: Nuclear Medicine Source Type: research

Nuclear medicine practice in Japan: a report of the eighth nationwide survey in 2017
ConclusionsSingle-photon examinations showed a continuous tendency toward a decline in the survey. In contrast, the number of hybrid SPECT/CT scanner examinations has increased. PET/CT study and radionuclide targeted therapy have steadily increased. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - June 24, 2019 Category: Nuclear Medicine Source Type: research

Combining the radiomic features and traditional parameters of 18 F-FDG PET with clinical profiles to improve prognostic stratification in patients with esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and surgery
AbstractObjectivesTo investigate the role of the traditional and radiomic parameters of18F-FDG PET for predicting the outcomes of patients with esophageal squamous cell carcinoma (SqCC).MethodsForty-four patients with primary esophageal SqCC who underwent neoadjuvant chemoradiotherapy (CCRT) followed by esophagectomy (tri-modality treatment) were retrospectively analyzed. All patients underwent18F-FDG PET/CT before and after neoadjuvant CCRT. The radiomic features were calculated using the pre-treatment PET scan. Pre-treatment radiomic features and changes in the PET-derived traditional parameters after neoadjuvant CCRT we...
Source: Annals of Nuclear Medicine - June 19, 2019 Category: Nuclear Medicine Source Type: research

Development of visual scoring system with Tc-99m DMSA renal scintigraphy to predict the risk of recurrence of symptomatic urinary tract infections in pediatric patients
AbstractObjectiveVesicoureteral reflux (VUR) is a major risk factor for recurrent symptomatic urinary tract infection (UTI) in pediatric patients. In addition, dimercaptosuccinic acid renal scintigraphy (DMSA) is an important diagnostic modality of VUR. However, the value of DMSA for predicting recurrent pediatric UTI has not been studied. Therefore, we aimed to develop visual scoring system (VSS) with DMSA to predict the risk of recurrence of symptomatic urinary tract infection in pediatric patient under the age of 24  months.MethodsPediatric UTI patients who visited our tertiary hospital emergency department and und...
Source: Annals of Nuclear Medicine - June 18, 2019 Category: Nuclear Medicine Source Type: research

Limited role of carbidopa-assisted 18 F-FDOPA PET/CT in patients with sporadic non-functional gastroduodenal neuroendocrine neoplasms
Conclusions18F-FDOPA PET/CT is not sufficiently accurate for localization of primary well-differentiated nonfunctioning sporadic gastroduodenal NENs.18F-FDOPA PET/CT ’s value for the assessment of visceral and lymph node metastases needs to be clarified in multicenter trials including a larger number of patients. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - June 15, 2019 Category: Nuclear Medicine Source Type: research

A reduced liver 18 F-FDG uptake may be related to hypoalbuminemia in patients with malnutrition
AbstractObjective18F-FDG PET/CT is a hybrid imaging method widely used as a useful, noninvasive imaging modality for evaluating various neoplastic diseases. When assessing the tumor uptake, the liver and the mediastinal blood pool are often used as a reference region. In daily clinical practice, the18F-FDG uptake in the liver sometimes appears to decrease on PET images of patients with malnutrition. The purpose of this study was to investigate whether or not the liver18F-FDG uptake is decreased in patients with malnutrition.MethodsWe retrospectively analyzed 246 patients who underwent18F-FDG PET/CT from January 2018 to Jun...
Source: Annals of Nuclear Medicine - June 14, 2019 Category: Nuclear Medicine Source Type: research

The use of molecular volumetric parameters for the evaluation of Lu-177 PSMA I & amp;T therapy response and survival
AbstractPurposeThe primary aim of this study was to evaluate the volumetric therapy response via Ga-68 PSMA I&T PET/CT in patients treated with Lu-177 PSMA I&T therapy. The secondary purpose was to determine the impact of volumetric parameter responses to overall survival.MethodsPSMA tumor volumes (PSMA-TV) and tumor lesion PSMA expressions (TL-PSMA) were calculated with a semi-automatic program on Ga-68 PSMA I&T PET/CT images that were obtained before and after Lu-177 PSMA I&T therapies with 19 patients. The median overall survival was compared with PSMA-TV, TL-PSMA, SUVmax, PSA, and alteration in PERCIST ...
Source: Annals of Nuclear Medicine - June 13, 2019 Category: Nuclear Medicine Source Type: research

Prediction of occult lymph node metastasis using SUV, volumetric parameters and intratumoral heterogeneity of the primary tumor in T1-2N0M0 lung cancer patients staged by PET/CT
ConclusionsIn conclusion, MTV was an independent predictor of OLM in cT1-2N0M0 ADC patients, while HF might be the most powerful predictor for OLM in SQCC. These findings would be helpful in selecting patients who might be considered as candidates for sublobar resection or new stereotactic ablative radiotherapy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - June 10, 2019 Category: Nuclear Medicine Source Type: research

18 F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma and correlation with clinical and genetic findings
This study analyzed18F-FDG PET/CT in PSC and possible correlations with the clinical and genetic findings.MethodsPre-operative18F-FDG PET/CT findings and parameters of maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of primary lesion (MTV-P, TLG-P), and combination of primary lesion and metastases (MTV-C, TLG-C) were retrospectively analyzed in 24 patients with PSC confirmed by post-operative pathology. Tumor location, size, TNM stage, serum tumor markers, histopathological features, and mutations were also reviewed. Furthermore, progression-free survival (PFS) of 24 ...
Source: Annals of Nuclear Medicine - June 5, 2019 Category: Nuclear Medicine Source Type: research

Novel 3D heart left ventricle muscle segmentation method for PET-gated protocol and its verification
ConclusionsThe analysis of gated PET data by the proposed method results in volume measurements comparable to established methods. Phantom experiments demonstrate that the volume values correspond to the physical ones. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - June 1, 2019 Category: Nuclear Medicine Source Type: research

Improved identification of patients with oligometastatic clear  cell renal cell carcinoma with PSMA-targeted 18 F-DCFPyL PET/CT
ConclusionsPSMA-targeted PET/CT appears to aid in the identification of patients with oligometastatic clear  cell RCC. If borne out in future studies, this suggests that PSMA-targeted imaging has the potential to help select candidates for metastasis-directed therapy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 30, 2019 Category: Nuclear Medicine Source Type: research

How to recognize stent graft infection after endovascular aortic repair: the utility of 18F-FDG PET/CT in an infrequent but serious clinical setting
AbstractObjectiveTo evaluate the diagnostic performance of18F-FDG PET/CT in the detection of stent graft infection (SGI).MethodsIn a retrospective study, two nuclear medicine physicians have independently analyzed 1718F-FDG PET/CT examinations performed for clinical suspicion of SGI. The images were evaluated for the uptake pattern and intensity, and by the maximum standard uptake value (SUVmax), the target-to-background ratio with blood pool (TBRBP) and liver uptake (TBRhep) as a reference. The SGI was defined as the presence of focal hyperactivity with an intensity exceeding hepatic uptake. CT images were independently a...
Source: Annals of Nuclear Medicine - May 29, 2019 Category: Nuclear Medicine Source Type: research

Radiation dosimetry and pharmacokinetics of florbetapir ( 18 F) in Japanese subjects
(Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 28, 2019 Category: Nuclear Medicine Source Type: research

Effect of brain atrophy in quantitative analysis of 123 I-ioflupane SPECT
AbstractObjectiveDopamine transporter (DAT) imaging such as123I-ioflupane (123I-FP-CIT) SPECT is a useful tool for the diagnosis of parkinsonism and dementia. The Southampton method is the quantitative method for evaluating123I-FP-CIT SPECT and is less affected by the partial volume effect of the striatum. The method may be vulnerable to contamination by low-uptake areas of cerebrospinal fluid in whole brain, and the threshold of voxel value (threshold method, TM) was developed to correct the contamination. The purpose of this study is to evaluate the TM in the patients with neurological disease.MethodsWe studied 99 subjec...
Source: Annals of Nuclear Medicine - May 28, 2019 Category: Nuclear Medicine Source Type: research

Amyloid PET imaging in cardiac amyloidosis: a pilot study using 18 F-flutemetamol positron emission tomography
ConclusionAmyloid PET tracers such as18F-flutemetamol could be a promising tool in diagnosing and in therapy response assessment for patients with cardiac amyloidosis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 28, 2019 Category: Nuclear Medicine Source Type: research

A novel dual-modality imaging agent targeting folate receptor of tumor for molecular imaging and fluorescence-guided surgery
ConclusionsIn vivo and in vitro studies revealed substantial and specific uptake of Tc-99m Folate-ECG-ROX in FR-positive tumors. Thus, Tc-99m Folate-ECG-ROX could provide both pre-operative molecular imaging and fluorescence image-guidance for tumor. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 27, 2019 Category: Nuclear Medicine Source Type: research

Microliter-ordered automatic blood sampling system for fully quantitative analysis of small-animal PET
ConclusionsThe automated microliter-ordered blood sampling system developed in the present study appears to be useful for absolute quantification of CMRglc in mice PET studies. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 22, 2019 Category: Nuclear Medicine Source Type: research

Factors affecting accuracy of S values and determination of time-integrated activity in clinical Lu-177 dosimetry
ConclusionErrors from estimating the time-integrated activity and approximations applied to dose kernel computations contribute about equally and represent the dominant contributions far exceeding the contributions from VOI segmentation and activimeter accuracy. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 22, 2019 Category: Nuclear Medicine Source Type: research

Distribution pattern of FDG uptake using ring-type dedicated breast PET in comparison to whole-body PET/CT scanning in invasive breast cancer
ConclusionsDbPET can identify detailed FDG distribution patterns of breast cancer better than wbPET. Breast cancer with RU on dbPET was associated with higher grade and triple-negative subtype. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Source Type: research

Up-front F18-FDG PET/CT in suspected salivary gland carcinoma
ConclusionsCompared with MRI/CXR PET/CT did not improve discrimination of benign from malignant salivary gland lesions. However, PET/CT may be advantageous in primary staging and in the detection of distant metastases and synchronous cancers. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 17, 2019 Category: Nuclear Medicine Source Type: research

The difference of risk factors predicting cardiac events in patients with chronic kidney disease between with and without diabetes
ConclusionsIn patients with CKD, while the risk factors of major cardiac events differ between in patients with and without diabetes, quantitation with gated MPI could be used effectively in both groups. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 15, 2019 Category: Nuclear Medicine Source Type: research

Evaluation of the effects of chemotherapy on brain glucose metabolism in children with Hodgkin ’s lymphoma
Conclusions18F-FDG PET/CT is useful in providing objective data to explain brain disorders caused by chemotherapy. This could lead to better care and should be compared to neuropsychological test results. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - May 13, 2019 Category: Nuclear Medicine Source Type: research

The role of ( 68 Ga)PSMA I & amp;T in biochemical recurrence after radical prostatectomy: detection rate and the correlation between the level of PSA, Gleason score, and the SUV max
AbstractObjectiveThe aim of the study was to retrospectively evaluate the recurrence detection rate of Gallium-68-prostate-specific membrane antigen [(68Ga)PSMA] imaging and therapy (I&T) positron emission tomography/computed tomography (PET/CT) at different PSA levels, which enables early detection of patients with radical prostatectomy. We also aimed to compare Gleason scores, used drugs (LHRH analogs and antiandrogens), PSA levels with SUVmax values, and detection rates.MethodThis retrospective study included 107 patients who underwent radical prostatectomy and who underwent (68Ga)PSMA I&T PET/CT imaging between...
Source: Annals of Nuclear Medicine - May 8, 2019 Category: Nuclear Medicine Source Type: research

Measurement of cerebral vascular reserves with I-123 IMP SPECT without an arterial input function using the microsphere model and radiopharmaceutical dose calibration
AbstractObjectivesCerebral vascular reserve (CVR) is an important indicator for the management of and therapy for cerebral arterial occlusive disease (CAOD). Vasodilatory function is measured using the standard IMP-ARG method. The IMP autoradiography (IMP-ARG) method employed here uses a standardized input function, which was derived from 12 patients between 31 and 71  years of age. Because the population of elderly patients continues to increase in Japan, additional therapies are required to assess CVR in elderly patients with chronic cardiopulmonary disease or a history of smoking, in particular. Despite its popular...
Source: Annals of Nuclear Medicine - April 13, 2019 Category: Nuclear Medicine Source Type: research

A novel biomarker, active whole skeletal total lesion glycolysis (WS-TLG), as a quantitative method to measure bone metastatic activity in breast cancer patients
ConclusionThis quantitative WS-TLG method appears to be a good biomarker to evaluate skeletal metastasis in breast cancer patients, especially lytic or mixed types. Further clinical studies are warranted to assess the clinical values of this new WS-TLG method. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 13, 2019 Category: Nuclear Medicine Source Type: research

Diagnostic performance of 18 F-FDG PET-CT for large vessel involvement assessment in patients with suspected giant cell arteritis and negative temporal artery biopsy
Conclusions18F-FDG PET-CT is a useful imaging technique to assess large vessel involvement in patients with suspected GCA and negative TAB. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 11, 2019 Category: Nuclear Medicine Source Type: research

Development of anatomically and lesion contrast-guided partial volume correction: new 3D formalisms and validation in phantom and clinical studies
ConclusionIt has been successful to generate 3D mathematical formulations of the SUV RC taking into consideration the most influential factors including lesion size and lesion contrast. Validation studies were suggestive of the good performance of the new mathematical algorithms generated to correct for PVE. However, further studies are underway to ensure the performance of the proposed algorithms in clinical PET studies. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 8, 2019 Category: Nuclear Medicine Source Type: research

Comparison between the different doses of radioactive iodine ablation prescribed in patients with intermediate-to-high-risk differentiated thyroid cancer
This study aimed to compare the clinical outcomes of patients who received radioactive iodine (RAI) ablation after undergoing thyroidectomy for intermediate-to-high-risk differentiated thyroid carcinoma (DTC) according to the American Thyroid Association (ATA) criteria.MethodsWe retrospectively examined patients who underwent RAI ablation for DTC after surgical resection without macroscopic residual lesions or metastatic lesions between December 2011 and August 2016. Among 147 patients who underwent RAI ablation, those whose initial pathological stages or RAI ablation results were unknown and whose distant metastases were ...
Source: Annals of Nuclear Medicine - April 6, 2019 Category: Nuclear Medicine Source Type: research

Development of a p38 α-selective radioactive probe for qualitative diagnosis of cancer using SPECT
ConclusionsThis study suggests that [123I]m-YTM has potential as a p38 α imaging probe effective for various cancer types. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 5, 2019 Category: Nuclear Medicine Source Type: research

Overall survival and progression-free survival in patients with primary brain tumors after treatment: is the outcome of [ 18 F] FDOPA PET a prognostic factor in these patients?
ConclusionsA positive [18F] FDOPA PET/CT scan is related to a poor OS and PFS in subjects with low-grade PBT. This imaging modality could be considered as a prognostic factor in these subjects. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 4, 2019 Category: Nuclear Medicine Source Type: research

Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in mantle cell lymphoma
ConclusionsEotPET/CT results (using DC), MTV and TLG were significantly correlated with response to treatment and PFS. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 30, 2019 Category: Nuclear Medicine Source Type: research

A systematic performance evaluation of head motion correction techniques for  3 commercial PET scanners using a reproducible experimental acquisition protocol
ConclusionsIn this study, we proposed a reproducible experimental framework to allow the systematic validation and comparison of multiple motion tracking and correction methodologies among different PET/CT and PET/MR commercial systems. Our proposed validation platform may be useful for future studies evaluating state-of-the-art motion correction strategies in clinical PET imaging. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 29, 2019 Category: Nuclear Medicine Source Type: research

Preliminary clinical assessment of dynamic 18 F-fluorodeoxyglucose positron emission tomography/computed tomography for evaluating lymph node metastasis in patients with lung cancer: a prospective study
ConclusionsBased on the visual and semiquantitative analyses,18F-FDG dynamic PET/CT exhibited excellent performance with extremely high specificity in the dynamic second phase. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 25, 2019 Category: Nuclear Medicine Source Type: research

123 I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults
ConclusionWe found no statistically significant age-related decline in SBR in adults over 60  years of age without Lewy body disease. Commercial software packages that apply a fixed rate of age correction may be overcorrecting for age in older adults, which could contribute to misdiagnosis. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 21, 2019 Category: Nuclear Medicine Source Type: research

Potential utility of bone scan in cranial bone flap osteomyelitis
ConclusionUsing well-defined and reproducible scintigraphic signs, bone scan is helpful for the diagnosis of BFO. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 18, 2019 Category: Nuclear Medicine Source Type: research

The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function
ConclusionsThe OSAS severity alone may not predict A β deposition in OSAS patients with normal cognition. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 18, 2019 Category: Nuclear Medicine Source Type: research

18 F-NaF-PET/CT for the detection of bone metastasis in prostate cancer: a meta-analysis of diagnostic accuracy studies
AbstractPurposeThis meta-analysis aims to establish the diagnostic performance of18F-NaF-PET/CT for the detection of bone metastases in prostate cancer patients. The performance of18F-NaF-PET/CT was compared with other imaging techniques in the same cohort of patients.MethodsA systematic search was performed in PubMed/Medline and EMBASE (last Updated, September 28, 2018). Studies with histopathology confirmation and/or clinical/imaging follow-up as reference standard were eligible for inclusion.ResultsA total of 14 studies were included. Twelve studies including 507 patients provided per-patient basis information. The pool...
Source: Annals of Nuclear Medicine - March 15, 2019 Category: Nuclear Medicine Source Type: research

Preliminary results of biodistribution and dosimetric analysis of [ 68 Ga]Ga-DOTA ZOL : a new zoledronate-based bisphosphonate for PET/CT diagnosis of bone diseases
ConclusionsBiodistribution of [68Ga]Ga-DOTAZOL was comparable to [18F]NaF, [99mTc]Tc-MDP and [68Ga]Ga-PSMA-617. With proper hydration and diuresis to reduce urinary bladder and kidney absorbed doses, it has clear advantages over [18F]NaF owing to its onsite, low-cost production and theranostic potential of personalized dosimetry for treatment with [177Lu]Lu-DOTAZOL and [225Ac]Ac-DOTAZOL. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - March 15, 2019 Category: Nuclear Medicine Source Type: research

Impaired brain dopamine transporter in chemobrain patients submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1
AbstractPurpose“Chemobrain” is a medical secondary effect of cancer chemotherapy treatment characterized by a general decline in cognition affecting visual and verbal memory, attention, complex problem-solving skills, and motor function. Dopamine (DA) central nervous system neurotransmitters serve an important role in cognition, and changes in DA could potentially explain impaired cognition associated with chemotherapy. Therefore, our objective was to assess in vivo dopaminergic dysfunction in the central nervous system (CNS) of a group of female breast cancer survivors with cognitive impairment followin g chem...
Source: Annals of Nuclear Medicine - March 7, 2019 Category: Nuclear Medicine Source Type: research

Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2
ConclusionsThis study revealed that total distribution volumes of the LAT1-targeting PET tracers18F-FBPA and18F-FAMT were independent of the tumor blood flow and might reflect the functional expression levels of LAT1 in the C6 glioma and MIA PaCa-2 xenograft models. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 28, 2019 Category: Nuclear Medicine Source Type: research

4-Borono-2- 18 F-fluoro- l -phenylalanine PET for boron neutron capture therapy-oriented diagnosis: overview of a quarter century of research
Abstract4-10B-Borono-2-18F-fluoro-l-phenylalanine (18F-FBPA) was developed for monitoring the pharmacokinetics of 4-10B-borono-l-phenylalanine (10B-BPA) used in boron neutron capture therapy (BNCT) with positron emission tomography (PET). The tumor-imaging potential of18F-FBPA was demonstrated in various animal models. Accumulation of18F-FBPA was higher in melanomas than in non-melanoma tumors in animal models and cell cultures.18F-FBPA was incorporated into tumors mediated mainly by L-type amino acid transporters in in vitro and in vivo models. Tumoral distribution of18F-FBPA was primarily related to the activity of DNA s...
Source: Annals of Nuclear Medicine - February 28, 2019 Category: Nuclear Medicine Source Type: research

The use of 3 ′-deoxy-3′- 18 F-fluorothymidine (FLT) PET in the assessment of long-term survival in breast cancer patients treated with neoadjuvant chemotherapy
ConclusionFurther study of a larger sample size is needed to examine the potential role for FLT-PET in predicting response to neoadjuvant treatment, particularly in correlating with long-term overall and progression-free survival. Our study is limited by small sample size, but does suggest that FLT-PET has a role in the long-term prognosis of breast cancer treated with NAC and surgical resection which is worthy of further study. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 27, 2019 Category: Nuclear Medicine Source Type: research

Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site
ConclusionsThese studies suggest that the binding properties of [18F]AV-1451 and [18F]THK5351 are sufficient to expect highlighting of tissues with a high density of MCCs. The findings of the present study should aid the development of neuroimaging ligands that do not bind to MCC. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 22, 2019 Category: Nuclear Medicine Source Type: research

Prognostic role of ΔMTV and ΔTLG in Burkitt lymphoma
ConclusionsMetabolic tumor features ( ΔMTV and ΔTLG) were significantly correlated with response to treatment and long-term outcome in BL. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 20, 2019 Category: Nuclear Medicine Source Type: research

Clinicopathological predictors of positive 68 Ga-PSMA-11 PET/CT in PSA-only recurrence of localized prostate cancer following definitive therapy
ConclusionsIn BCR of localized PCa following definitive therapy, pre-scan PSA was strongly associated with positive68Ga-PSMA-11 scan, even at PSA levels ranging from 0.2 to 1.0  ng/ml. Therefore, clinical and pathological predictors of positive68Ga-PSMA-11 PET/CT in PSA-only recurrence of localized prostate cancer need to be further elucidated. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 18, 2019 Category: Nuclear Medicine Source Type: research

Evaluation of whole-body tumor burden with 68 Ga-PSMA PET/CT in the biochemical recurrence of prostate cancer
The objective of this study was to calculate the whole-body tumo r burden using volumetric quantification of lesions detected in68Ga-PSMA-PET of prostate cancer patients with biochemical recurrence and correlate these findings with clinical and image parameters.MethodsEach patient had their68Ga-PSMA-PET analyzed for the presence of neoplastic lesions. Their PSA levels and clinical information were recorded. In positive cases, the tumor burden (TL-PSMA) was calculated with a semi-automatic software and manually, and the results are analyzed and tested.ResultsWe analyzed 100 prostate cancer patients, mean age of 69.9 &thinsp...
Source: Annals of Nuclear Medicine - February 11, 2019 Category: Nuclear Medicine Source Type: research

Development of radiolabeled bis(zinc(II)-dipicolylamine) complexes for cell death imaging
Conclusion[99mTc]Tc-MAG3-EG2-ZnDPA could be useful for the early detection of treatment effects after chemotherapy. Since the signal-to-noise ratio is not enough for single photon emission computed tomography imaging, further modification is needed to improve its biodistribution and affinity for PS. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - February 6, 2019 Category: Nuclear Medicine Source Type: research