Anxiety Levels in Brazilian Women with Metastatic Breast Cancer Undergoing Palliative Chemotherapy: A Prospective Study
CONCLUSION: Women with breast cancer undergoing palliative chemotherapy exhibited high trait-anxiety scores, which decreased significantly over the course of treatment.PMID:38679972 | DOI:10.31557/APJCP.2024.25.4.1135 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Larissa Marcondes Leonel Dos Santos Silva Cristiano De Oliveira Ribeiro Natalia Naome Oshiro Luciana De Alcantara Nogueira Paulo Ricardo Bittencourt Guimaraes Luciana Puchalski Kalinke Source Type: research
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
This study demonstrates that ferroptosis contributes to baicalein-induced anti-CRC activity through blockade of the JAK2/STAT3/GPX4 signaling pathway, which provides evidence for the therapeutic application of baicalein against CRC.PMID:38684798 | DOI:10.1038/s41401-024-01258-z (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - April 29, 2024 Category: Drugs & Pharmacology Authors: Jian-Qin Lai Le-le Zhao Chao Hong Qiu-Ming Zou Jin-Xuan Su Si-Jia Li Xiao-Feng Zhou Zi-Sheng Li Bo Deng Jie Cao Qi Qi Source Type: research
Expandable endoprostheses in skeletally immature patients: Where we are
World J Orthop. 2024 Apr 18;15(4):312-317. doi: 10.5312/wjo.v15.i4.312. eCollection 2024 Apr 18.ABSTRACTApproximately 45 percent of malignant bone tumors are seen under the age of 16 and one of the important results of growth plate sacrification in patients with immature skeletons is limb inequality. Until the early 1990s, the treatment options for these patients were rotationplasty or amputation. Multimodal approaches that combine imaging, chemotherapy, and surgical techniques have enabled the development of limb-preserving methods with satisfactory results. In order to overcome inequality problems, expandable prostheses ...
Source: World Journal of Orthopaedics - April 29, 2024 Category: Orthopaedics Authors: Recep Öztürk Source Type: research
PBAC: A pathway-based attention convolution neural network for predicting clinical drug treatment responses
J Cell Mol Med. 2024 May;28(9):e18298. doi: 10.1111/jcmm.18298.ABSTRACTPrecise and personalized drug application is crucial in the clinical treatment of complex diseases. Although neural networks offer a new approach to improving drug strategies, their internal structure is difficult to interpret. Here, we propose PBAC (Pathway-Based Attention Convolution neural network), which integrates a deep learning framework and attention mechanism to address the complex biological pathway information, thereby provide a biology function-based robust drug responsiveness prediction model. PBAC has four layers: gene-pathway layer, atten...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Dexun Deng Xiaoqiang Xu Ting Cui Mingcong Xu Kunpeng Luo Han Zhang Qiuyu Wang Chao Song Chao Li Guohua Li Desi Shang Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
PBAC: A pathway-based attention convolution neural network for predicting clinical drug treatment responses
J Cell Mol Med. 2024 May;28(9):e18298. doi: 10.1111/jcmm.18298.ABSTRACTPrecise and personalized drug application is crucial in the clinical treatment of complex diseases. Although neural networks offer a new approach to improving drug strategies, their internal structure is difficult to interpret. Here, we propose PBAC (Pathway-Based Attention Convolution neural network), which integrates a deep learning framework and attention mechanism to address the complex biological pathway information, thereby provide a biology function-based robust drug responsiveness prediction model. PBAC has four layers: gene-pathway layer, atten...
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Dexun Deng Xiaoqiang Xu Ting Cui Mingcong Xu Kunpeng Luo Han Zhang Qiuyu Wang Chao Song Chao Li Guohua Li Desi Shang Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
Treatment with nanosomal paclitaxel lipid suspension < em > versus < /em > conventional paclitaxel in metastatic breast cancer patients - a multicenter, randomized, comparative, phase II/III clinical study
CONCLUSION: NPLS demonstrated an improved tumor response rate and a favorable safety profile versus conventional paclitaxel. NPLS 80 mg/m2 QW demonstrated a significantly better response versus conventional paclitaxel 175 mg/m2 Q3W.TRIAL REGISTRATION: Clinical Trial Registry-India (CTRI), CTRI/2010/091/001344 Registered on: 18 October 2010 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjEzNQ==&Enc=&userName=CTRI/2010/091/001344), CTRI/2015/07/006062 Registered on: 31 July 2015 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTE2Mjc=&Enc=&userName=CTRI/2015/07/006062).PMID:38680290 | PMC:...
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Chiradoni Thungappa Satheesh Rakesh Taran Jitendra Kumar Singh Shanti Prakash Shrivastav Nikunj K Vithalani Kalyan Kusum Mukherjee Rajnish Vasant Nagarkar Tanveer Maksud Ajay Omprakash Mehta Krishnan Srinivasan Mummaneni Vikranth Satish Ramkrishna Sonawan Source Type: research
Advancements in steroidal Pt(II) & amp; Pt(IV) derivatives for targeted chemotherapy (2000-2023)
Eur J Med Chem. 2024 Apr 20;271:116438. doi: 10.1016/j.ejmech.2024.116438. Online ahead of print.ABSTRACTOne of the key strategies in chemotherapy involves crosslinking the DNA strands of cancer cells to impede their replication, with platinum (Pt) coordination compounds being a prominent class and cisplatin being its major representative. Steroidal ligands tethered to DNA interactive Pt core act as drug carriers for targeted therapy. While crosslinking of nuclear or mitochondrial DNA strands using coordination complexes has been studied for years, there remains a lack of comprehensive reviews addressing the advancements m...
Source: European Journal of Medicinal Chemistry - April 29, 2024 Category: Chemistry Authors: Hamdullah Khadim Sheikh Cindy Juliet Cristancho Ortiz Tanzila Arshad Jos é M Padrón Haroon Khan Source Type: research
Increased Th17 and Treg levels in peripheral blood positively correlate with minimal residual disease in acute myeloid leukaemia
CONCLUSION: Increased Th17 and Treg cell levels were positively correlated with onset of AML, poor remission, and MRD.PMID:38682816 | DOI:10.1080/16078454.2024.2346971 (Source: Hematology)
Source: Hematology - April 29, 2024 Category: Hematology Authors: Zhimin Wang Tangxia Liu Yanru Li Zunchang Li Kehong Bi Source Type: research
OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1-p62/SQSTM1 complex
CONCLUSION: We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway, and that this effect is mediated by the RIPK1-p62/SQSTM1 complex, in CRC cells. These results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.PMID:38681991 | PMC:PMC11045482 | DOI:10.3748/wjg.v30.i15.2155 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Nan Wang Chao-Yang Li Teng-Fei Yao Xiao-Dan Kang Hui-Shu Guo Source Type: research
Synergistic effects of < em > Bacillus coagulans < /em > and < em > Newcastle disease virus < /em > on human colorectal adenocarcinoma cell proliferation
CONCLUSION: It appears that utilizing oncolytic viruses (OV) and bacteria in conjunction with chemotherapy drugs could potentially aid in reducing the growth of colorectal cancer cells. However, further research is necessary, including animal studies, to confirm the efficacy of this treatment method.PMID:38682055 | PMC:PMC11055439 | DOI:10.18502/ijm.v16i1.14878 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Hadi Esmaeili Gouvarchinghaleh Cyrus Jalili Maryam Zamir Nasta Fatemeh Mokhles Elmira Afrasiab Farhad Babaei Source Type: research
OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1-p62/SQSTM1 complex
CONCLUSION: We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway, and that this effect is mediated by the RIPK1-p62/SQSTM1 complex, in CRC cells. These results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.PMID:38681991 | PMC:PMC11045482 | DOI:10.3748/wjg.v30.i15.2155 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Nan Wang Chao-Yang Li Teng-Fei Yao Xiao-Dan Kang Hui-Shu Guo Source Type: research
Transfusion management and hemoglobin-based oxygen carrier treatment in a patient with anti-Rh17 antibody
DISCUSSION: Overall difficulties in this case included the challenge of finding compatible units, dilemma of transfusing incompatible units in a patient with severe anemia and obtaining alternatives to blood products. This case report demonstrates the successful use of HBOC-21 in treating life-threatening anemia.PMID:38682958 | DOI:10.1111/trf.17855 (Source: Transfusion)
Source: Transfusion - April 29, 2024 Category: Hematology Authors: Noah Mehr Christine Fuja Cody Simon Timothy Carll Rahaf Alkhateb Sulin Wu Anand A Patel Fatima Aldarweesh Source Type: research
A plain language summary of the TROPHY-U-01 study: sacituzumab govitecan use in people with locally advanced or metastatic urothelial cancer
CONCLUSIONS REPORTED BY THE RESEARCHERS?: The study showed that sacituzumab govitecan had significant anti-cancer activity. Though most participants who received sacituzumab govitecan experienced side effects, these did not usually stop participants from continuing sacituzumab govitecan. Doctors can help control these side effects using treatment guidelines, but these side effects can be serious. Clinical Trial Registration: NCT03547973 (ClinicalTrials.gov) (TROPHY-U-1).PMID:38682560 | DOI:10.2217/fon-2023-1030 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Yohann Loriot Arash Rezazadeh Kalebasty Aude Fl échon Rohit K Jain Sumati Gupta Manojkumar Bupathi Philippe Beuzeboc Phillip Palmbos Arjun V Balar Christos E Kyriakopoulos Damien Pouessel Cora N Sternberg Julia Tonelli Mitch Sierecki Huafeng Zhou Petros Source Type: research
