Spatial profiling of ovarian carcinoma and tumor microenvironment evolution under neoadjuvant chemotherapy
CONCLUSIONS: Several iTMEs exist during tumor evolution and NACT impact on iTME is heterogeneous. Clustering analysis of patients, unravels several IC subsets within OC and can guide future personalized approaches. Targeting different checkpoints such as TIM-3, LAG-3 and IDO-1, more prevalent than PD-L1, could more effectively harness anti-tumor immunity in this anti-PD-L1 resistant malignancy.PMID:38669064 | DOI:10.1158/1078-0432.CCR-23-3836 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 26, 2024 Category: Cancer & Oncology Authors: Elisa Yaniz-Galende Qinghe Zeng Juan Francisco Grau-Bejar Christophe Klein F élix Blanc-Durand Audrey Le Formal Eric Pujade-Lauraine Laure Chardin Elodie Edmond Virginie Marty Isabelle Ray-Coquard Florence Joly Gwena ël Ferron Patricia Pautier Dominique Source Type: research
Peripheral blood biomarkers associated with combination of immune checkpoint blockade plus chemotherapy in NSCLC
CONCLUSIONS: We conclude that NK cells, CD4 + PD-1 + Tim-3 + T cells, and CXCL10 levels in pre-treatment peripheral blood may predict the efficacy of combination of ICI/chemotherapy in NSCLC.PMID:38669521 | DOI:10.3233/CBM-230301 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - April 26, 2024 Category: Cancer & Oncology Authors: Nozomu Kimura Yoko Tsukita Risa Ebina-Shibuya Eisaku Miyauchi Mitsuhiro Yamada Daisuke Narita Ryota Saito Chihiro Inoue Naoya Fujino Tomohiro Ichikawa Tsutomu Tamada Hisatoshi Sugiura Source Type: research
Differential synergistic effects of palbociclib and doxorubicin on doxorubicin-resistant cancer cells with diverse tumor origins
J Chemother. 2024 Apr 25:1-9. doi: 10.1080/1120009X.2024.2345454. Online ahead of print.ABSTRACTPalbociclib is a dual inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). Palbociclib has frequently been studied in breast cancer cells and has also been linked to function of P-glycoprotein (P-gp), main protein responsible for cancer drug resistance. However, the effect of Palbociclib on cancer drug resistance and specifically doxorubicin-resistant cells overexpressing P-gp have limitedly been studied in the literature. Here, we aimed to decipher the possible synergistic effects of Palbociclib and Doxorubicin combination t...
Source: Journal of Chemotherapy - April 26, 2024 Category: Cancer & Oncology Authors: Gizem Damla Yalcin Pelin Mutlu Hasan Huseyin Kazan Ufuk Gunduz Source Type: research
Longitudinal brain volumetrics in glioma survivors
CONCLUSIONS: This study demonstrated volume loss in contralateral brain structures among LGG survivors, and patients who received RT experienced greater volume loss than those who did not. The results of this study may help to provide context for cognitive outcome research in LGG survivors and inform the design of future strategies to preserve cognition.PMID:38669700 | DOI:10.3171/2024.1.JNS231980 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 26, 2024 Category: Neurosurgery Authors: Andrew M McDonald Donna L Murdaugh Katherine A Heinzman Rex A Cardan Jessica Jacob John B Fiveash L Burt Nabors Courtney A Cooper John M Hoyle Desmin Milner Carlos E Cardenas Source Type: research
Peripheral blood biomarkers associated with combination of immune checkpoint blockade plus chemotherapy in NSCLC
CONCLUSIONS: We conclude that NK cells, CD4 + PD-1 + Tim-3 + T cells, and CXCL10 levels in pre-treatment peripheral blood may predict the efficacy of combination of ICI/chemotherapy in NSCLC.PMID:38669521 | DOI:10.3233/CBM-230301 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - April 26, 2024 Category: Cancer & Oncology Authors: Nozomu Kimura Yoko Tsukita Risa Ebina-Shibuya Eisaku Miyauchi Mitsuhiro Yamada Daisuke Narita Ryota Saito Chihiro Inoue Naoya Fujino Tomohiro Ichikawa Tsutomu Tamada Hisatoshi Sugiura Source Type: research
