Highly Cytotoxic Cu(II) Terpyridine Complexes as Chemotherapeutic Agents
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Kaixin Ni, Nicol ás Montesdeoca, Johannes Karges Cancer is considered as the biggest medicinal challenge worldwide. During a typical treatment, the tumorous tissue is removed in a surgical procedure and the patient further treated by chemotherapy. One... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - April 19, 2024 Category: Chemistry Authors: Kaixin Ni Source Type: research
Identification of Prognostic Markers of Glioblastoma through Bioinformatics Analysis
CONCLUSION: The prognostic risk model can effectively classify patients with glioblastoma into high-risk and low-risk groups in terms of overall survival rate, which may help select high-risk patients with glioblastoma for more intensive treatment.PMID:38639614 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Jieying Wen Haojie Zheng Xi Yuan Cuilan Huang Xiaogang Yang Zhiying Lin Guanglong Huang Source Type: research
Effector Function Characteristics of Exhausted CD8+ T-cell in Microsatellite Stable and Unstable Gastric Cancer
CONCLUSION: Our study reveals novel finding indicating that IFN-γ signaling pathway is retained in Tex and pTex of MSI-H gastric cancer, offering a comprehensive perspective for future investigations into immunotherapy for gastric cancer.PMID:38637967 | DOI:10.4143/crt.2024.317 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Dong-Seok Han Yoonjin Kwak Seungho Lee Soo Kyung Nam Seong-Ho Kong Do Joong Park Hyuk-Joon Lee Nak-Jung Kwon Hye Seung Lee Han-Kwang Yang Source Type: research
GSE264352 Enfortumab Vedotin Induces Immunogenic Cell Death and Shows Enhanced Preclinical Antitumor Activity When Combined With a PD-1 Inhibitor
Contributors : Devra J Olson ; Patrick Younan ; Bernard A Liu ; Gabriele Blahnik-Fagan ; John J Gosink ; Katie Snead ; Elena Tenn ; Kelly Hensley ; Disha Saheytya ; Albina Nestrerova ; Margo Zaval ; Anthony Cao ; Christine O'Day ; Ryan A Heiser ; Timothy S Lewis ; Shyra J Gardai ; Taisuke Nakazawa ; Masashi Shimazaki ; Christopher Carosina ; Sharsti SandallSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusEnfortumab vedotin is a Nectin-4-directed antibody –drug conjugate designed to deliver the microtubule-disrupting agent monomethyl auristatin E (MMAE) in...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
Buprenorphine as a Treatment for Severe Chemotherapy-Induced Neuropathy – A Case Report
1. Understand the basic clinical uses of buprenorphine and describe a case where buprenorphine was used to treat chemotherapy-associated neuropathy.2. Identify potential areas for future research regarding the use of buprenorphine for chemotherapy-induced neuropathy. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Jonathan Abraham, Byoungchul Kim Source Type: research
Neoadjuvant chemoimmunotherapy shows major pathological response and low recurrence in head and neck squamous cell carcinoma
ConclusionNeoadjuvant chemoimmunotherapy of HNSCC showed high rate of pathological response and low recurrence rate, holding promise for becoming the new standard of care for resectable HNSCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Conditional survival analysis and real-time prognosis prediction in stage III T3 –T4 colon cancer patients after surgical resection: a SEER database analysis
ConclusionsOur study developed nomograms and predictive models for postoperative stage III survival in T3 –T4 colon cancer with the aim of accurately estimating conditional survival. Survival bias in our analyses may lead to overestimation of survival outcomes, which may limit the applicability of our findings. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 19, 2024 Category: Gastroenterology Source Type: research
Cancers, Vol. 16, Pages 1565: Genetic Diagnosis of Retinoblastoma Using Aqueous Humour & mdash;Findings from an Extended Cohort
Cancers, Vol. 16, Pages 1565: Genetic Diagnosis of Retinoblastoma Using Aqueous Humour—Findings from an Extended Cohort
Cancers doi: 10.3390/cancers16081565
Authors:
Amy Gerrish
Chipo Mashayamombe-Wolfgarten
Edward Stone
Claudia Román-Montañana
Joseph Abbott
Helen Jenkinson
Gerard Millen
Sam Gurney
Maureen McCalla
Sarah-Jane Staveley
Anu Kainth
Maria Kirk
Claire Bowen
Susan Cavanagh
Sancha Bunstone
Megan Carney
Ajay Mohite
Samuel Clokie
M. Ashwin Reddy
Alison Foster
Stephanie Allen
Manoj Parulekar
Trevor Cole
The identification of somatic RB1 variation is cruc...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Amy Gerrish Chipo Mashayamombe-Wolfgarten Edward Stone Claudia Rom án-Montañana Joseph Abbott Helen Jenkinson Gerard Millen Sam Gurney Maureen McCalla Sarah-Jane Staveley Anu Kainth Maria Kirk Claire Bowen Susan Cavanagh Sancha Bunstone Megan Carney Aja Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1567: Discovery of Novel Potential Prognostic Markers and Targeted Therapy to Overcome Chemotherapy Resistance in an Advanced-Stage Wilms Tumor
In this study, we aimed to discover potential mutation markers and drug targets associated with chemotherapy resistance in advanced-stage WT. We performed exome sequencing to detect somatic mutations and molecular targets in 43 WT samples, comprising 26 advanced-stage WTs, of which 7 cases were chemotherapy-resistant. Our analysis revealed four genes (ALPK2, C16orf96, PRKDC, and SVIL) that correlated with chemotherapy resistance and reduced disease-free survival in advanced-stage WT. Additionally, we identified driver mutations in 55 genes within the chemotherapy-resistant group, including 14 druggable cancer driver genes....
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Pongsakorn Choochuen Natakorn Nokchan Natthapon Khongcharoen Wison Laochareonsuk Komwit Surachat Thirachit Chotsampancharoen Thanit Sila Sangkhathat Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1559: Pressurised Intraperitoneal Aerosolised Chemotherapy & mdash;Results from the First Hundred Consecutive Procedures
Cancers, Vol. 16, Pages 1559: Pressurised Intraperitoneal Aerosolised Chemotherapy—Results from the First Hundred Consecutive Procedures
Cancers doi: 10.3390/cancers16081559
Authors:
David Hoskovec
Zdeněk Krška
Michal Vočka
Soňa Argalácsová
Petr Dytrych
PIPAC is a new and promising technique for the intraperitoneal administration of chemotherapy. It can be used in patients with various peritoneal cancer metastases. It is mainly a palliative treatment, but there is some neoadjuvant treatment potential. We have operated on 41 patients with various intra-abdominal cancers. PIPAC was performed e...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: David Hoskovec Zden ěk Krška Michal Vo čka So ňa Argalácsová Petr Dytrych Tags: Article Source Type: research
French national survey on breast cancer care: caregiver and patient views
CONCLUSIONS: This study provides an updated analysis of breast cancer care pathways in France. Overall, the initial processes of diagnosis, announcement, and treatment were swift and were in agreement with the best care standards. No barriers to accessing care were identified. Based on the study findings, we proposed several strategies to improve the quality of care for patients in supportive care, coordination with primary care physicians, reconstructive surgery, and fertility preservation access.PMID:38635135 | DOI:10.1007/s12282-024-01576-4 (Source: Breast Cancer)
Source: Breast Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Christine Rousset-Jablonski Barbara Lortal Sophie Lantheaume Laurent Arnould H élène Simon Anne-Sophie Tuszynski M élanie Courtier Soukayna Debbah Marc Lefran çois Sita Balbin Anne-Sophie Kably Alain Toledano Source Type: research
High Financial Hardship among Patients with Advanced Ovarian Cancer
This study evaluated financial toxicity in patients with advanced ovarian cancer. Using secondary data from a study of barriers to palliative care, financial toxicity (FT) was measured through the Comprehensive Score for Financial Toxicity scale. Univariate and bivariate analyses were used to assess the relationship between selected demographic (i.e., age, race, ethnicity, education, place of birth, insurance type, yearly household income, employment status) and treatment-specific variables (i.e., years since diagnosis, surgery, chemotherapy, radiation, hormonal and targeted therapy) with clinically relevant financial toxi...
Source: Journal of Social Work in End-of-Life and Palliative Care - April 18, 2024 Category: Palliative Care Authors: Elsa Maria Vasquez-Trespalacios Jessica N Rivera Rivera McKenzie McIntyre Waleska Santiago-Datil Robert M Wenham Susan T Vadaparampil Andrea L Buras Claire C Conley Source Type: research
Inflammatory breast cancer: As surgical oncologists, what can we do?
Int Rev Cell Mol Biol. 2024;384:113-124. doi: 10.1016/bs.ircmb.2024.02.004. Epub 2024 Mar 28.ABSTRACTBreast cancer surgery is the primary treatment for early-stage breast cancer. However, inflammatory breast cancer (IBC), with its specific presentation characterized by skin invasion, is unfit for primary surgery. According to the different guidelines, the management of IBC is trimodal with the coordination of oncologists, surgeons, and radiation therapists. Advances in breast cancer imaging and the development of more targeted therapies make new challenges for this aggressive cancer. This chapter aims to provide an update ...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Hatem Bouzaiene Fatma Saadallah Hanen Bouaziz Olfa Jaidane Jamel Ben Hassouna Tarak Dhieb Khaled Rahal Source Type: research
Inflammatory breast cancer: Epidemiologic data and therapeutic results
In this study, we reviewed the literature using the Surveillance, Epidemiology, and End Results (SEER) database compared to other published series. We observed that in the high incidence areas (North of Africa) when compared to "classical" breast cancer, IBC was associated to younger age (less than 50 years) with rapid evolution of signs and symptoms (in less than 3 up to 6 months), and more aggressive clinical and histopathological-molecular parameters, due to the predominance of triple-negative and HER2+ subtypes in around 60% of cases. An epidemiologic trend was observed in both high and low incidence areas since the ei...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Hamouda Boussen Yosra Berrazaga None Sherif Kullab Maroua Manai Narjess Berrada Nesrine Mejri Ismail Siala Paul H Levine Massimo Cristofanilli Source Type: research
Gallbladder cancer: surgical treatment, immunotherapy, and targeted therapy
Postgrad Med. 2024 Apr 18. doi: 10.1080/00325481.2024.2345585. Online ahead of print.ABSTRACTGallbladder cancer is a common type of biliary tract tumor. Optimal management for early stage cases typically involves radical excision as the primary treatment modality. Various surgical techniques, including laparoscopic, robotic, and navigational surgery, have demonstrated favorable clinical outcomes in radical gallbladder excision. Unfortunately, most patients are ineligible for surgical intervention because of the advanced stage of the disease upon diagnosis. Consequently, non-surgical interventions, such as chemotherapy, rad...
Source: Postgraduate Medicine - April 18, 2024 Category: Internal Medicine Authors: Yanjun Sun Junfeng Gong Zhuang Li Lin Han Dengqun Sun Source Type: research
