The Impact of Tumor Hypoxia Modulation on sIL-2R Levels in Newly Diagnosed Diffuse Large B Cell Lymphoma (DLBCL) Patients Undergoing Chemotherapy: A Randomized Clinical Trial
CONCLUSION: Tumor hypoxia modulation led to a significant decrease in serum sIL-2R levels, potentially through improvements in the crosstalk between hypoxia and inflammation pathways.PMID:38679992 | DOI:10.31557/APJCP.2024.25.4.1315 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Daniel Rizky Kevin Tandarto Eko Adhi Pangarsa Ridho M Naibaho Sigit P Kurniawan Damai Santosa Budi Setiawan Catharina Suharti Source Type: research
Investigations of Ni(II)Cysteine-Tyrosine Dithiocarbamate Complex: Synthesis, Characterization, Molecular Docking, Molecular Dynamic, and Anticancer Activity on MCF-7 Breast Cancer Cell Line
CONCLUSION: there were 5 residues responsible for maintaining the ligand binding stable. The compound had significant Hbond contact intensity, however, it was not strong enough to make a significant anticancer effect. Though the synthesized compound shows low bioactivity, this research is expected to give valuable insight into the effect of molecular structure on anticancer activity.PMID:38679991 | DOI:10.31557/APJCP.2024.25.4.1301 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Eka Pratiwi Indah Raya Hasnah Natsir Rizal Irfandi Paulina Taba Rugaiyah Arfah Herlina Rasyid Yusafir Hala Syahruddin Kasim Andi Besse Khaerunnisa Baso Ilham Maulida Mazaya Yosua Tanzil Dewi Luthfiana Source Type: research
Outcomes of Induction Chemotherapy Followed by Chemoradiotherapy Versus Chemoradiotherapy Alone in Esophageal Squamous Cell Carcinoma Induction chemotherapy in Esophageal Squamous Cell Carcinoma
CONCLUSION: Our data demonstrated that a combination of IC and CRT might be a promising treatment strategy to further improve OS in ESCC patients.PMID:38679976 | DOI:10.31557/APJCP.2024.25.4.1183 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Saeed Hosseini Toudeshki Maryam Garousi Amir Mohammad Arefpour Pedram Fadavi Ali Basi Ahmad Foroughi Seyed Alireza Javadinia Source Type: research
Anxiety Levels in Brazilian Women with Metastatic Breast Cancer Undergoing Palliative Chemotherapy: A Prospective Study
CONCLUSION: Women with breast cancer undergoing palliative chemotherapy exhibited high trait-anxiety scores, which decreased significantly over the course of treatment.PMID:38679972 | DOI:10.31557/APJCP.2024.25.4.1135 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Larissa Marcondes Leonel Dos Santos Silva Cristiano De Oliveira Ribeiro Natalia Naome Oshiro Luciana De Alcantara Nogueira Paulo Ricardo Bittencourt Guimaraes Luciana Puchalski Kalinke Source Type: research
Targeted and immunotherapy for the management of advanced urothelial carcinoma of the bladder
CONCLUSION: Six targeted and immunotherapeutic agents have been approved for patients with advanced urothelial bladder cancer. They all have demonstrated activity in patients for whom disease has progressed during or after platinum-based therapy. Pembrolizumab, with and without enfortumab, has demonstrated first-line activity, and avelumab is a key maintenance therapy after first-line treatment. The results of additional clinical trials should provide evidence to establish the exact role in therapy of each agent in patients with advanced disease.PMID:38679913 | DOI:10.1093/ajhp/zxae090 (Source: American Journal of Health-S...
Source: American Journal of Health-System Pharmacy : AJHP - April 29, 2024 Category: Drugs & Pharmacology Authors: Robert J Cersosimo Source Type: research
Staging and systemic treatment of ocular and periocular metastases
Ophthalmologie. 2024 Apr 29. doi: 10.1007/s00347-024-02034-4. Online ahead of print.ABSTRACTMetastases of malignant diseases are the most frequent tumors diagnosed in the human eye. They occur in approximately 5-10% of patients with solid tumors during the course of the disease. Their frequency is particularly high in patients with breast and lung cancer. Many highly sensitive periorbital tissues can be affected by the localization of the metastatic lesions and pose a number of clinical challenges. The main goal of the therapy of ocular metastases consists of the control of tumor growth (including the control of other poss...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Daniela D örfel Neele Babst Ludwig Maximillian Heindl Vinodh Kakkassery Martin R M üller Source Type: research
A plain language summary of the TROPHY-U-01 study: sacituzumab govitecan use in people with locally advanced or metastatic urothelial cancer
CONCLUSIONS REPORTED BY THE RESEARCHERS?: The study showed that sacituzumab govitecan had significant anti-cancer activity. Though most participants who received sacituzumab govitecan experienced side effects, these did not usually stop participants from continuing sacituzumab govitecan. Doctors can help control these side effects using treatment guidelines, but these side effects can be serious. Clinical Trial Registration: NCT03547973 (ClinicalTrials.gov) (TROPHY-U-1).PMID:38682560 | DOI:10.2217/fon-2023-1030 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Yohann Loriot Arash Rezazadeh Kalebasty Aude Fl échon Rohit K Jain Sumati Gupta Manojkumar Bupathi Philippe Beuzeboc Phillip Palmbos Arjun V Balar Christos E Kyriakopoulos Damien Pouessel Cora N Sternberg Julia Tonelli Mitch Sierecki Huafeng Zhou Petros Source Type: research
Synergistic effects of < em > Bacillus coagulans < /em > and < em > Newcastle disease virus < /em > on human colorectal adenocarcinoma cell proliferation
CONCLUSION: It appears that utilizing oncolytic viruses (OV) and bacteria in conjunction with chemotherapy drugs could potentially aid in reducing the growth of colorectal cancer cells. However, further research is necessary, including animal studies, to confirm the efficacy of this treatment method.PMID:38682055 | PMC:PMC11055439 | DOI:10.18502/ijm.v16i1.14878 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Hadi Esmaeili Gouvarchinghaleh Cyrus Jalili Maryam Zamir Nasta Fatemeh Mokhles Elmira Afrasiab Farhad Babaei Source Type: research
The Effect of Tumor Resection and Radiotherapy on the Expression of Stem Cell Markers (CD44 and CD133) in Patients with Squamous Cell Carcinoma
Conclusion: The results also indicated that the expression of CD44 significantly decreased after tumor resection and radiotherapy. The upregulation of mRNA level of Bcl-2 and ALDH, and the downregulation of Bax and Bak gene expression were noted in these cases when compared to the healthy control group.PMID:38680713 | PMC:PMC11055418 | DOI:10.18502/ijhoscr.v18i1.14748 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Ladan Paya Ali Rafat Mehdi Talebi Amirala Aghbali Nikzad Shahidi Babak Nejati Parya Emamverdizadeh Hojjatollah Nozad Charoudeh Source Type: research
Influence of blood glucose fluctuations on chemotherapy efficacy and safety in type 2 diabetes mellitus patients complicated with lung carcinoma
CONCLUSION: The greater the BG fluctuation in LC patients after chemotherapy, the more unfavorable the therapeutic effect of chemotherapy; the higher the level of tumor markers and inflammatory cytokines, the more adverse reactions the patient experiences.PMID:38680689 | PMC:PMC11045413 | DOI:10.4239/wjd.v15.i4.645 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Tian-Zheng Fang Xian-Qiao Wu Ting-Qi Zhao Shan-Shan Wang Guo-Mei-Zhi Fu Qing-Long Wu Cheng-Wei Zhou Source Type: research
Treatment with nanosomal paclitaxel lipid suspension versus conventional paclitaxel in metastatic breast cancer patients - a multicenter, randomized, comparative, phase II/III clinical study
CONCLUSION: NPLS demonstrated an improved tumor response rate and a favorable safety profile versus conventional paclitaxel. NPLS 80 mg/m2 QW demonstrated a significantly better response versus conventional paclitaxel 175 mg/m2 Q3W.TRIAL REGISTRATION: Clinical Trial Registry-India (CTRI), CTRI/2010/091/001344 Registered on: 18 October 2010 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjEzNQ==&Enc=&userName=CTRI/2010/091/001344), CTRI/2015/07/006062 Registered on: 31 July 2015 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTE2Mjc=&Enc=&userName=CTRI/2015/07/006062).PMID:38680290 | PMC:...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Chiradoni Thungappa Satheesh Rakesh Taran Jitendra Kumar Singh Shanti Prakash Shrivastav Nikunj K Vithalani Kalyan Kusum Mukherjee Rajnish Vasant Nagarkar Tanveer Maksud Ajay Omprakash Mehta Krishnan Srinivasan Mummaneni Vikranth Satish Ramkrishna Sonawan Source Type: research
Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
Evaluation of Central Nervous System Relapse in Adults with Acute Lymphoblastic Leukemia (ALL) Receiving Hyper-CVAD Treatment in Seyyed Al-Shohada Hospital: Isfahan, 2014-2019
Conclusion: This study shows that the prognosis of CNS relapse in adults with ALL has not improved much. Limited studies have been conducted on the recurrence of the central nervous system in adults with acute lymphoblastic leukemia. Therefore, further studies on CNS relapse after complete remission of ALL are required to clarify more details.PMID:38680719 | PMC:PMC11055424 | DOI:10.18502/ijhoscr.v18i1.14743 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Alireza Sadeghi Reyhane Gardashti Farzaneh Ashrafi Valiollah Mehrzad Source Type: research
The Effect of Tumor Resection and Radiotherapy on the Expression of Stem Cell Markers (CD44 and CD133) in Patients with Squamous Cell Carcinoma
Conclusion: The results also indicated that the expression of CD44 significantly decreased after tumor resection and radiotherapy. The upregulation of mRNA level of Bcl-2 and ALDH, and the downregulation of Bax and Bak gene expression were noted in these cases when compared to the healthy control group.PMID:38680713 | PMC:PMC11055418 | DOI:10.18502/ijhoscr.v18i1.14748 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Ladan Paya Ali Rafat Mehdi Talebi Amirala Aghbali Nikzad Shahidi Babak Nejati Parya Emamverdizadeh Hojjatollah Nozad Charoudeh Source Type: research
Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study
ConclusionChildhood cancer (CC) patients undergoing antineoplastic therapy (AT) exhibit a higher prevalence of dental caries, regardless of income/education, frequency of sugar intake, stimulated salivary flow rate, and microbiota. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 29, 2024 Category: Cancer & Oncology Source Type: research
