An overview on liposarcoma subtypes: Genetic alterations and recent advances in therapeutic strategies
AbstractLiposarcoma (LPS) is a rare malignancy of adipocytic differentiation. According to World Health Organization classification, LPS comprises of four principle subtypes Atypical lipomatous tumor/Well-differentiated liposarcoma (ATL/WDLPS), Dedifferentiated liposarcoma (WDLPS), Myxoid liposarcoma (MLPS), and Pleomorphic liposarcoma (PLPS). Each subtype can develop at any location and shows distinct clinical behavior and treatment sensitivity. ATL/ WDLPS subtype has a higher incidence rate, low recurrence, and is insensitive to radiation and chemotherapy. DDLPS is the focal progression of WDLPS, which is aggressive and ...
Source: Journal of Molecular Histology - May 2, 2024 Category: Laboratory Medicine Source Type: research
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis
G protein–coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs) and is selectively expressed in satellite glial cells (SGCs). Peripheral neuropathy induced by streptozotoxin (STZ) and paclitaxel (PTX) led to reduced GPR37L1 expression on the plasma membrane in mouse and human DRGs. Transgenic mice with Gpr37l1 deficiency exhibited impaired resolution of neuropathic pain symptoms following PTX- and STZ-induced pain, whereas overexpression of Gpr37l1 in m...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchen Source Type: research
Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status
CONCLUSION: In this population-based study using the NCDB, immunotherapy treatment was associated with significantly improved OS compared to chemotherapy in patients with MSI-H metastatic colorectal cancer, but not in those with MSI-L/MSS metastatic colorectal cancer. Further studies are warranted to determine the optimal therapeutic approach for patients with MSI-L/MSS metastatic colorectal cancer.PMID:38689622 | PMC:PMC11056865 | DOI:10.5306/wjco.v15.i4.540 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Chen-Gu Niu Jing Zhang Aniket-Vijay Rao Utsav Joshi Patrick Okolo Source Type: research
Initiating chemotherapy in joint arthroplasty patients increases the risk of periprosthetic joint infections
CONCLUSIONS: This study reveals a possible relationship between postoperative chemotherapy and an increased incidence of PJI in patients with arthroplasty. Chemotherapy suppresses the immune system, rendering patients more vulnerable to infections. Additional research is required to confirm these findings.PMID:38693289 | DOI:10.1007/s00402-024-05307-4 (Source: Cancer Control)
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Amir Human Hoveidaei Amirhossein Ghaseminejad-Raeini Seyed Hossein Hosseini-Asl Ashesh Shrestha Armin Hoveidaei Seyed Pouya Taghavi Basilia Onyinyechukwu Nwankwo Mohammad Saeid Khonji Janet D Conway Source Type: research
Impact of the thyroid hormone T3 and its nuclear receptor TRalpha1 on colon cancer stem cell phenotypes and response to chemotherapies
Cell Death Dis. 2024 May 1;15(5):306. doi: 10.1038/s41419-024-06690-x.ABSTRACTColorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development, maintenance, and drug resistance. Our previous studies showed the importance of thyroid hormone-dependent signaling on intestinal tumor development and progression through action on stem cells. These results have a translational value, given that the thyroid hormone nuclear receptor TRα1 is upregulated in human CRCs, including in the molecular subtypes associated with CSC features. We used an e...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Maria Virginia Giolito Serguei Bodoirat Theo La Rosa Mathieu Reslinger Gabriela D A Guardia Jana Mourtada Leo Claret Alain Joung Pedro A F Galante Luiz O F Penalva Michelina Plateroti Source Type: research
Evaluating the effect of a mobile-based symptom monitoring system for improving physical function in patients with cancer during chemotherapy: study protocol for a multicentre randomised controlled trial
This study is a multicentre, open-label, parallel-group, randomised controlled trial. We will recruit 372 patients at three tertiary hospitals located in Seoul, South Korea. Study participants will be randomly assigned to either an intervention group receiving the ePRO-CTCAE app and a control group receiving routine clinical practice only. The primary outcome is changes in physical function from commencement to completion of planned chemotherapy. A linear mixed model will be performed under the intention-to-treat principle. The secondary outcomes include physical activity level; changes in pain interference; changes in dep...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Mangyeong Lee Danbee Kang Yesol Um Bokyung Jo Jeong Rhue Sehhoon Park Yoo-Young Lee Joseph J Noh Yun-Gyoo Lee Dong-Hoe Koo Kyong-Hwa Park Soohyeon Lee Jin Seok Ahn Dongryul Oh Juhee Cho Source Type: research
Model Predictive Control (MPC) Applied to a Simplified model, Magnetic Nanoparticle Hyperthermia (MNPH) Treatment Process
Biomed Phys Eng Express. 2024 May 1. doi: 10.1088/2057-1976/ad460a. Online ahead of print.ABSTRACTMagnetic nanoparticle hyperthermia (MNPH) has emerged as a promising cancer treatment that complements the conventional ionizing radiation and chemotherapy. MNPH involves the injection of iron oxide nanoparticles into the tumor and exposure to an alternating magnetic field (AMF). Iron oxide nanoparticles generate heat due to hysteresis loss when exposed to radiofrequency AMF. Exposing human tissue to AMF causes non-specific heating in tissues through induced eddy currents, which must be minimized. A pulse-width-modulated AMF h...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Ma'Moun Abu-Ayyad Yash Lad Dario Aguilar Kiana Karami Anilchandra Attaluri Source Type: research
Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy
Transl Oncol. 2024 Apr 30;45:101975. doi: 10.1016/j.tranon.2024.101975. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds of therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor is still incurable, requiring novel strategies for its treatment. The nanomedicine has provided the new insights regarding the treatment of cancer that liposomes as lipid-based nanoparticles, have been wid...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Seyedeh Setareh Samaei Mahshid Daryab Sarah Gholami Aryan Rezaee Navid Fatehi Romina Roshannia Saeed Hashemi Nazanin Javani Parham Rahmanian Reza Amani-Beni Mohammad Arad Zandieh Noushin Nabavi Mohsen Rashidi Neda Malgard Mehrdad Hashemi Afshin Taheriazam Source Type: research
[Retracted] Effect of microRNA-27b on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma via FZD7 signaling pathway
Oncol Lett. 2024 Apr 22;27(6):275. doi: 10.3892/ol.2024.14408. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/ol.2019.10347.].PMID:38690102 | PMC:PMC11058706 | DOI:10.3892/ol.2024.14408 (Source: Oncology Letters)
Source: Oncology Letters - May 1, 2024 Category: Cancer & Oncology Authors: Bingyao Liu Gang Cao Zhen Dong Ting Guo Source Type: research
Unveiling the promise of PD1/PD-L1: A new dawn in immunotherapy for cholangiocarcinoma
This article seeks to meticulously review the latest studies on PD1/PD-L1 involvement in CCA, delving into their expression profiles, prognostic significance, contribution to oncogenic processes, and their potential clinical utility.PMID:38692063 | DOI:10.1016/j.biopha.2024.116659 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Fei Chen Jian Sheng Xiaoping Li Zhaofeng Gao Siqi Zhao Lingyu Hu Minjie Chen Jianguo Fei Zhengwei Song Source Type: research
Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy
Transl Oncol. 2024 Apr 30;45:101975. doi: 10.1016/j.tranon.2024.101975. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds of therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor is still incurable, requiring novel strategies for its treatment. The nanomedicine has provided the new insights regarding the treatment of cancer that liposomes as lipid-based nanoparticles, have been wid...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Seyedeh Setareh Samaei Mahshid Daryab Sarah Gholami Aryan Rezaee Navid Fatehi Romina Roshannia Saeed Hashemi Nazanin Javani Parham Rahmanian Reza Amani-Beni Mohammad Arad Zandieh Noushin Nabavi Mohsen Rashidi Neda Malgard Mehrdad Hashemi Afshin Taheriazam Source Type: research
EP300 through upregulating the expression of vimentin to promote the progression of chordoma
CONCLUSIONS: These findings indicate that EP300 functions as an oncogene in chordoma. Targeting EP300 offers a novel approach to the development and clinical treatment of chordoma.PMID:38691868 | DOI:10.3171/2024.2.FOCUS244 (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2024 Category: Neurosurgery Authors: Lingzhi Wen Bin Xie Hui Li Jun Huang Ying Shi Yongguang Tao Yuanbing Chen Source Type: research
Effective bridging strategies prior to infusion with tisagenlecleucel results in high response rates and long-term remission in relapsed/refractory large B-cell lymphoma: findings from a German monocentric study
CONCLUSION: The study underscores the importance of minimal tumor burden at CAR-T initiation, emphasizing the need for suitable bridging regimens. The findings advocate for clinical trials and further real-world analyses to optimize CAR-T cell therapy outcomes by identifying the most effective bridging strategies.PMID:38693452 | DOI:10.1007/s00432-024-05765-8 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Farina Eigendorff Irina Filimonova Sebastian Scholl Anne Sayer-Klink Silke Rummler Christa Kunert Klaus Pietschmann Andrea Wittig Andreas Hochhaus Ulf Schnetzke Source Type: research
The potential role of circular RNAs -regulated PI3K signaling in non-small cell lung cancer: Molecular insights and clinical perspective
Pathol Res Pract. 2024 Apr 16;257:155316. doi: 10.1016/j.prp.2024.155316. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC), accounting for more than 80% of all cases, is the predominant form of lung cancer and the leading cause of cancer-related deaths worldwide. Significant progress has been made in diagnostic techniques, surgical interventions, chemotherapy protocols, and targeted therapies at the molecular level, leading to enhanced treatment outcomes in patients with NSCLC. Extensive evidence supports the use of circular RNAs (circRNAs), a specific category of naturally occurring non-coding small RNAs (...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Samaneh Kahkesh Seyedeh Mahdieh Khoshnazar Yasaman Gholinezhad Shakiba Esmailzadeh Seyed Ali Hosseini Mina Alimohammadi Alireza Mafi Source Type: research
Insights into the activity of cefiderocol against PER-2 producing Enterobacterales
In this study, we explored the stability of cefiderocol (FDC) against PER-2 β-lactamase to gain insights into structure activity relationships (SAR) of this synthetic siderophore-conjugated antibiotic. Herein, we show that the MICs of FDC for PER-2 producing isolates and transformants ranged between 0.125 and 64 µg/mL; diazabicyclooctanes (DBOs) reduced the MIC values. In PER-2 mutants, MIC values decreased up to 10-12 dilutions in agreement with previous observations especially in the case of Arg220 substitutions. Catalytic efficiency for PER-2 was 0.072 µM-1 s-1, comparable with PER-1 (0.046 µM-1 s-1) and NDM-1 (0.06...
Source: Antimicrobial Agents and Chemotherapy - May 1, 2024 Category: Microbiology Authors: Melina Ruggiero Ivan Brice ño Muñoz Gabriel Gutkind Andrea M Hujer Robert A Bonomo Pablo Power Source Type: research
