Deciphering resistance mechanisms and novel strategies to overcome drug resistance in ovarian cancer: a comprehensive review
Oncol Res. 2024 Apr 23;32(5):831-847. doi: 10.32604/or.2024.031006. eCollection 2024.ABSTRACTOvarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for ma...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Effat Alemzadeh Leila Allahqoli Afrooz Mazidimoradi Esmat Alemzadeh Fahimeh Ghasemi Hamid Salehiniya Ibrahim Alkatout Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Clinical Breast Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Clinical Genitourinary Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
Hepatic artery infusion chemotherapy with systemic capecitabine and camrelizumab for treating unresectable hilar cholangiocarcinoma: An initial investigation of efficacy and safety
CONCLUSION: HAIC sequentially combined with systemic capecitabine chemotherapy and a programmed death-1 inhibitor displayed favorable effects for unresectable HCCA, with controllable adverse reactions.PMID:38687927 | DOI:10.4103/jcrt.jcrt_1549_23 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Long Li Song Liu Qingdong Wang Yanhua Wang Guangji Yu Source Type: research
The efficacy of coaxial percutaneous iodine-125 seed implantation combined with arterial infusion chemotherapy for advanced pancreatic cancer: a randomized clinical trial
CONCLUSION: The combination of coaxial percutaneous 125I seed implantation with arterial infusion chemotherapy could significantly alleviate abdominal pain, improve tumor control rates, and prolong survival time in patients with advanced PC.PMID:38687687 | DOI:10.1080/09553002.2024.2347357 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: HongXiang Yao Ying ZhuGe ShiXiang Jin ShuiBing Chen HengYiTing Zhang Dong Zhang ZhiGang Chen Source Type: research
Hepatic arterial infusion chemotherapy, lenvatinib plus programmed cell death protein-1 inhibitors: A promising treatment approach for high-burden hepatocellular carcinoma
CONCLUSION: The combination of HAIC-FOLFOX with lenvatinib and PD-1 inhibitors as a first-line therapy has exhibited notable therapeutic efficacy and well-tolerated adverse events among patients with high-burden HCC.PMID:38686567 | DOI:10.1002/cam4.7105 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Shumin Fu Yongkang Xu Ye Mao Mengting He Zhimeng Chen Shenglan Huang Dan Li Yaqin Lv Jianbing Wu Source Type: research
Intraoperative radiofrequency ablation for unresectable abdominal paraganglioma: a case report
We presented the case of a 31-year-old man who had a 9-cm functioning unresectable PPGL. He was treated with 13 cycles of cytotoxic chemotherapy without objective tumor response, according to the Response Evaluation Criteria in Solid Tumors (RECIST). Subsequently, magnetic resonance imaging revealed a 9.0 × 8.6 × 6.0-cm retroperitoneal mass that extended to the inferior portion of the inferior vena cava, the inferior mesenteric artery, and the infrarenal aorta. Biochemical evaluation demonstrated high level of plasma normetanephrine (20.2 nmol/L, normal range <0.9 nmol/L). Genetic investigation showed the germline pat...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Isabelle P A Magalhaes Bibiana D Boger Nathalia L Gomes Guilherme L P Martins Leomarques A Bomfim Gustavo F C Fagundes Roberta S Rocha Fernando M A Coelho Jose L Chambo Ana Claudia Latronico Maria Candida B V Fragoso Ana O Hoff Berenice B Mendonca Marcos Source Type: research
Successful treatment with nivolumab in a patient with gastric cancer with severe liver failure resulting from multiple liver metastases: A case report
Oncol Lett. 2024 Apr 18;27(6):271. doi: 10.3892/ol.2024.14404. eCollection 2024 Jun.ABSTRACTGastric cancer (GC) is a globally prevalent and deadly malignancy often diagnosed at advanced stages, which can be accompanied by liver metastases. Conventional chemotherapy is contraindicated in patients with severe liver failure because several chemotherapeutic agents are metabolized by the liver. The present study reports on the successful use of nivolumab in a patient with advanced GC and severe liver failure owing to multiple liver metastases. A 57-year-old man was admitted to Shimane Prefectural Central Hospital (Izumo, Japan)...
Source: Oncology Letters - April 30, 2024 Category: Cancer & Oncology Authors: Fumiyoshi Ikejiri Kanako Yokomizo Kenji Tamura Source Type: research
Selective Avoidance of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Human Epidermal Growth Factor 2-Positive/Triple-Negative Breast Cancer Patients With Excellent Response
DISCUSSION: Several clinical trials are currently underway to determine whether SLNB can be omitted after NACT in patients with HER2+ BC or TNBC that are expected to achieve pathologic complete response. The ASLAN trial is expected to provide valuable clues regarding the feasibility of omitting axillary surgery in highly selected patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04993625. Registered on August 6, 2021. Clinical Research Information Service Identifier: KCT0006371. Registered on July 22, 2021.PMID:38685868 | DOI:10.4048/jbc.2023.0264 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Jai Min Ryu Hyunjun Lee Wonshik Han Han-Byoel Lee Sung Gwe Ahn Hee Jeong Kim Hyung Seok Park Ji Soo Choi Haeyoung Kim Won Kyung Cho Jeong Eon Lee Source Type: research
The efficacy of coaxial percutaneous iodine-125 seed implantation combined with arterial infusion chemotherapy for advanced pancreatic cancer: a randomized clinical trial
CONCLUSION: The combination of coaxial percutaneous 125I seed implantation with arterial infusion chemotherapy could significantly alleviate abdominal pain, improve tumor control rates, and prolong survival time in patients with advanced PC.PMID:38687687 | DOI:10.1080/09553002.2024.2347357 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 30, 2024 Category: Radiology Authors: HongXiang Yao Ying ZhuGe ShiXiang Jin ShuiBing Chen HengYiTing Zhang Dong Zhang ZhiGang Chen Source Type: research
New advances in the treatment of chondrosarcoma under the PD-1/PD-L1 pathway
J Cancer Res Ther. 2024 Apr 1;20(2):522-530. doi: 10.4103/jcrt.jcrt_2269_23. Epub 2024 Apr 30.ABSTRACTBone sarcomas encompass a group of spontaneous mesenchymal malignancies, among which osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma are the most common subtypes. Chondrosarcoma, a relatively prevalent malignant bone tumor that originates from chondrocytes, is characterized by endogenous cartilage ossification within the tumor tissue. Despite the use of aggressive treatment approaches involving extensive surgical resection, chemotherapy, and radiotherapy for patients with osteosarcoma, chondrosarcoma, and chordom...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jiawei Yin Peng Ren Source Type: research
Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer
Cancer Res Commun. 2024 Apr 24;4(4):1120-1134. doi: 10.1158/2767-9764.CRC-23-0468.ABSTRACTCombinations of immune checkpoint inhibitors (ICI, including anti-PD-1/PD-L1) and chemotherapy have been FDA approved for metastatic and early-stage triple-negative breast cancer (TNBC), but most patients do not benefit. B7-H4 is a B7 family ligand with proposed immunosuppressive functions being explored as a cancer immunotherapy target and may be associated with anti-PD-L1 resistance. However, little is known about its regulation and effect on immune cell function in breast cancers. We assessed murine and human breast cancer cells to...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Elizabeth C Wescott Xiaopeng Sun Paula Gonzalez-Ericsson Ann Hanna Brandie C Taylor Violeta Sanchez Juliana Bronzini Susan R Opalenik Melinda E Sanders Julia Wulfkuhle Rosa I Gallagher Henry Gomez Claudine Isaacs Vijaya Bharti John T Wilson Tarah J Ballin Source Type: research
A comparative < em > in vitro < /em > study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells
This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in intra...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Shahid Karim Alanoud Naher Alghanmi Maha Jamal Huda Alkreathy Alam Jamal Hind A Alkhatabi Mohammed Bazuhair Aftab Ahmad Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Journal of Applied Clinical Medical Physics - April 30, 2024 Category: Physics Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
circIARS: a potential plasma biomarker for diagnosing non-small cell lung cancer
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 29. doi: 10.3724/abbs.2024043. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC) is one of the most prevalent cancers in the world, and early diagnosis can effectively improve patient survival. Here, differentially expressed circIARS genes are screened from the sequencing results, and their molecular characteristics are examined by Sanger sequencing, RNase R assay, agarose gel electrophoresis (AGE), and fluorescence in situ hybridization (FISH). Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) is performed to detect the expression level of ...
Source: Acta Biochimica et Biophysica Sinica - April 30, 2024 Category: Biochemistry Authors: Qi Zhang Xinfeng Fan Xinyu Zhang Shaoqing Ju Source Type: research
