Effect of Adjuvant Hormonal Therapy on the Development of Pulmonary Fibrosis after Postoperative Radiotherapy for Breast Cancer.
Authors: Anzic M, Marinko T Abstract Breast cancer is the most common malignancy among women. Therefore, it is of paramount importance to study the adverse effects of oncological treatment of breast cancer, with one of adverse effects being pulmonary fibrosis (PF). PF is an irreversible condition and can significantly reduce the quality of life. Following lumpectomy, radiotherapy is the standard adjuvant treatment for breast cancer. Additionally, hormone receptor-positive breast cancers are treated with adjuvant hormonal therapy. While radiotherapy is one of the known causes of PF, the effect of hormone therapy on ...
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Comparison of Endocrine Therapies in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced or Metastatic Breast Cancer: A Network Meta-Analysis.
In conclusion, our results provide moderate evidence that fulvestrant plus palbociclib and AI plus everolimus were the most effective treatments, while the efficacy and safety of fulvestrant plus palbociclib was obviously superior in some specific clinical situations. PMID: 33154823 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Impact of the Updated Guidelines on Human Epidermal Growth Factor Receptor 2 (HER2) Testing in Breast Cancer.
Conclusion: Under the 2013 guidelines, the positive and equivocal cases increased. However, the 2018 guidelines eliminated ambiguous cases by reclassifying them as HER2-negative. PMID: 33154824 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinical Implications of Serum 25-Hydroxyvitamin D Status after 5-Year Adjuvant Endocrine Therapy for Late Recurrence of Hormone Receptor-positive Breast Cancer.
Conclusions: We found that 25(OH)D deficiency after the 5-year adjuvant endocrine therapy was associated with worse LRFS among HR-positive breast cancer patients, particularly with respect to regional LN, bone, and visceral recurrence. PMID: 33154825 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Predictive Value of Pre-therapeutic Serum Gamma-glutamyl transferase in Efficacy and Adverse Reactions to Neoadjuvant Chemotherapy among Breast Cancer Patients.
Authors: Sun L, Yin W, Wu Z, Wang Y, Lu J Abstract Purpose: Gamma-glutamyl transferase (GGT) has been reported as being involved in tumor progression. Previous studies documented a potential relationship between serum GGT level and survival outcome in several types of human malignancies. However, the association between serum GGT levels and response to neoadjuvant chemotherapy (NAC) has not yet been reported. The present study aimed to evaluate the association between pre-therapeutic serum GGT level and the efficacy, long-term survival, and adverse reactions of NAC and to investigate its role in predicting NAC sens...
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinical Impact of Primary Prophylactic Pegfilgrastim in Breast Cancer Patients Receiving Adjuvant Docetaxel-Doxorubicin-Cyclophosphamide Chemotherapy.
Conclusions: The use of pegfilgrastim during adjuvant TAC chemotherapy was significantly associated with a decrease in the incidence and risk of FN, hospital care costs, and risk of death compared to the use of adjuvant TAC without primary prophylaxis. PMID: 33154827 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Fascia Suture Technique Is a Simple Approach to Reduce Postmastectomy Seroma Formation.
Conclusion: The fascia suture technique is a simple and effective method for reducing seroma formation and should be used to prevent seroma formation after mastectomy. Trial Registration: Chinese Clinical Trials Registry Identifier: ChiCTR1800015913. PMID: 33154828 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Patient Perception of Telehealth Services for Breast and Gynecologic Oncology Care during the COVID-19 Pandemic: A Single Center Survey-based Study.
Authors: Zimmerman BS, Seidman D, Berger N, Cascetta KP, Nezolosky M, Trlica K, Ryncarz A, Keeton C, Moshier E, Tiersten A Abstract Prior to the coronavirus disease 2019 (COVID-19) pandemic, telehealth was rarely utilized for oncologic care in metropolitan areas. Our large New York City based outpatient breast/gynecologic cancer clinic administered an 18-question survey to patients from March to June 2020, to assess the perceptions of the utility of telehealth medicine. Of the 622 patients, 215 (35%) completed the survey, and of the 215 respondents, 74 (35%) had participated in a telehealth visit. We evaluated the ...
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Change in Estradiol Levels among Premenopausal Patients with Breast Cancer Treated Using Leuprolide Acetate 11.25 Milligrams 3-Month Depot and Tamoxifen.
This study was performed on patients who received the 3M LHRHa after surgery. The serum estradiol (E2) and follicle-stimulating hormone levels were measured before surgery, and periodically after surgery. In total, 318 patients were included in the study and analyzed. The mean E2 level before surgery was 63.7 pg/mL, while the mean E2 level during the administration of 3M LHRHa was 4.9 pg/mL. None of the patients were menstruating and had E2 values above 30.0 pg/mL. It is thought that the 3M LHRHa formulation can suppress the ovarian function effectively and be safely used to improve compliance. PMID: 33154830 [PubMed] ...
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Therapeutic Effect of Cyclin-Dependent Kinase 4/6 Inhibitor on Relapsed Ectopic Male Breast Cancer.
Authors: Baek DW, Park JY, Lee SJ, Chae YS Abstract Ectopic male breast cancer is very rare. Consequently, there is a lack of prospective clinical trials, and most recommendations for treatment are based on the experiences of clinicians and data from female breast cancer patients. The United States Food and Drug Administration has recently approved palbociclib combined with endocrine therapy for advanced male breast cancer because of the positive results of its use in metastatic female breast cancer. Therefore, it is worth considering cyclin-dependent kinase 4/6 inhibitors as alternatives to conventional chemothera...
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Recurrent Primary Pleomorphic Liposarcoma of the Breast: A Case Report with Imaging Findings.
Authors: Jo SJ, Jung HK, Nam KH Abstract Primary pleomorphic liposarcoma of the breast is rare, and only a few cases in the literature have reported imaging findings. Herein, we report a rare case of primary pleomorphic liposarcoma of the breast in a 38-year-old woman and describe the imaging findings including mammography, ultrasonography, computed tomography, magnetic resonance imaging, and 18F-Fluorodeoxyglucose-positron emission tomography. Although most fat-containing breast masses are benign, malignancy can occur. Magnetic resonance imaging can be helpful for further evaluation of breast masses. PMID: 331...
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Pro-inflammatory Cytokine Levels and Cancer-related Fatigue in Breast Cancer Survivors: Effects of an Exercise Adherence Program.
Authors: Kim SH, Song YK, Han J, Ko YH, Lee H, Kang MJ, Park H, Lee H, Kim S Abstract [This corrects the article on p. 205 in vol. 23, PMID: 32395379.]. PMID: 33154833 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Corrigendum: MiR-183-5p Promotes Proliferation, Metastasis and Angiogenesis in Breast Cancer Cells through Negatively Regulating Four and a Half LIM Protein 1.
Authors: Li Y, Zeng Q, Qiu J, Pang T, Ye F, Huang L, Zhang X Abstract [This corrects the article on p. 355 in vol. 23, PMID: 32908787.]. PMID: 33154834 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Corrigendum: Myeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling.
Authors: Luo A, Meng M, Wang G, Han R, Zhang Y, Jing X, Zhao L, Gu S, Zhao X Abstract [This corrects the article on p. 141 in vol. 23, PMID: 32395374.]. PMID: 33154835 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - November 11, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Breast Cancer Risk Prediction in Korean Women: Review and Perspectives on Personalized Breast Cancer Screening.
Authors: Kim DY, Park HL Abstract Due to an increasing proportion of older individuals and the adoption of a westernized lifestyle, the incidence rate of breast cancer is expected to rapidly increase within the next 10 years in Korea. The National Cancer Screening Program (NCSP) of Korea recommends biennial breast cancer screening through mammography for women aged 40-69 years old and according to individual risk and preference for women above 70 years old. There is an ongoing debate on how to most effectively screen for breast cancer, with many proponents of personalized screening, or screening according to indivi...
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

LncRNA DLG1-AS1 Promotes Cancer Cell Proliferation in Triple Negative Breast Cancer by Downregulating miR-203.
Conclusion: These results indicate that DLG1-AS1 may promote cancer cell proliferation in TNBC by downregulating the tumor suppressor miR-203. PMID: 32908786 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

MiR-183-5p Promotes Proliferation, Metastasis and Angiogenesis in Breast Cancer Cells through Negatively Regulating Four and a Half LIM Protein 1.
Conclusion: Our study suggests that miR-183-5p promotes cell proliferation, metastasis, and angiogenesis by negatively regulating FHL1 in BC. PMID: 32908787 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Analysis of Circulating Tumor DNA to Predict Neoadjuvant Therapy Effectiveness and Breast Cancer Recurrence.
Conclusion: Our study highlights the potential of ctDNA analysis at different timepoints for assessing tumor progression and treatment effectiveness, as well as prediction of breast cancer recurrence. PMID: 32908788 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Expression and Role of Epithelial Membrane Proteins in Tumorigenesis of Hormone Receptor-Positive Breast Cancer.
Conclusion: EMP2 may be involved in the early stage of tumor development in hormone-positive breast cancer. PMID: 32908789 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Hyperglycemia during Adjuvant Chemotherapy as a Prognostic Factor in Breast Cancer Patients without Diabetes.
Conclusion: These data suggest that hyperglycemia during adjuvant chemotherapy is a prognostic factor for RFS in breast cancer patients without diabetes. PMID: 32908790 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Updated Bayesian Network Meta-Analysis of Adjuvant Targeted Treatment Regimens for Early Human Epidermal Growth Factor Receptor-2 Positive Breast Cancer.
Conclusion: We conclude that 1-year adjuvant trastuzumab should remain as the standard treatment for HER2-positive EBC patients, as it has greater efficacy and a manageable proportion of AEs. Clinical efficacy can be increased for hormone receptor-negative tumors by including a second HER2-targeted agent to the treatment regimen. For hormone receptor-positive cases with basal disease, it is acceptable to reduce the risk of cardiotoxicity by shortening the duration of trastuzumab. PMID: 32908791 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Hints from a Female Patient with Breast Cancer Who Later Presented with Cowden Syndrome.
Authors: Wang WC, Hou TC, Kuo CY, Lai YC Abstract A 51-year-old woman presented with metachronous tumor development in bilateral breasts, thyroid, and endometrium. Additional signs and symptoms fulfilled the National Comprehensive Cancer Network criteria for Cowden syndrome. Immunohistochemistry showed loss of PTEN expression in all tumors. Single nucleotide variants, 647 germline variants (including one each in PTEN and MSH3), and 21 somatic mutations within exons were detected in all tumors after whole-exome sequencing. There were 0, 11, and 46 specific somatic mutations in bilateral breasts, thyroid, and endomet...
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Metachronous Sporadic Sextuple Primary Malignancies Including Bilateral Breast Cancers.
Authors: Hwang KT, Kim MJ, Chu AJ, Park JH, Kim J, Lee JY, Choi IS, Park JH, Chang JH, Hwang KR Abstract Multiple primary malignancies are defined as the presence of more than one malignant neoplasm with a distinct histology occurring at different sites in the same individual. They are classified as synchronous or metachronous according to the diagnostic time interval of different malignancies. Diagnosis of multiple primary malignancies should avoid misclassification from multifocal/multicentric tumors or recurrent/metastatic lesions. In multiple primary malignancies, with increase in the number of primary tumors, ...
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Myocardial Perfusion Imaging in Breast Cancer Patients.
Authors: Sioka C, Fotopoulos A PMID: 32908794 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 12, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy.
Authors: Faria SS, Corrêa LH, Heyn GS, de Sant'Ana LP, Almeida RDN, Magalhães KG Abstract Obesity is associated with increased risk and aggressiveness of many types of cancer. Women with obesity and breast cancer are more likely to be diagnosed with larger and higher-grade tumors and have higher incidence of metastases than lean individuals. Increasing evidence indicates that obesity includes systemic, chronic low-grade inflammation, and that adipose tissue can act as an important endocrine site, secreting a variety of substances that may regulate inflammation, immune response, and cancer predispositio...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Assessment of the Predictive Role of Serum Lipid Profiles in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.
This study aimed to investigate the predictive value of serum lipid profiles for the response to NAC in breast cancer patients. Methods: A total of 533 breast cancer patients who had received NAC were retrospectively studied. The pretreatment of serum lipids, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipoprotein-α, and clinicopathological characteristics were collected to assess their predictive roles. Results: Breast cancer patients had significantly lower TC, TG, HDL-C, and LDL-C levels than normal ind...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Relative Survival Benefit by Hormonal Receptor Status of Adding Trastuzumab to Neoadjuvant Chemotherapy in Breast Cancer Patients.
Conclusion: We found that the addition of trastuzumab to NAC improved relative survival benefit in HER2+/HR+ patients than in HER2+/HR- patients, even though the pCR rate increases were lower. Although pCR has been regarded as a surrogate marker for estimating long-term survival benefits after NAC, it alone may not translate into real long-term oncologic outcomes in particular cancer subtypes after trastuzumab-based NAC. Further longer-term evaluation of the objective survival benefit after NAC driven by a dual HER2 block according to HR status is warranted. PMID: 32595988 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Effect of Timing of Gonadotropin-Releasing Hormone Agonist Administration for Ovarian Protection in Patients with Breast Cancer.
Conclusion: There was no difference in the ovarian protective effect according to the difference in the timing of administration of GnRHa. PMID: 32595989 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Identifying Long-Term Survival Candidates among Patients with Isolated Locoregionally Recurrent Breast Cancer: Implications of the Use of Systemic Chemotherapy.
Authors: Kim BH, Shin KH, Chie EK, Kim JH, Kim K, Hwang KT, Kim J, Choi IS, Park JH, Kim S Abstract Purpose: We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods: We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results: Fifty-two (41.6%) patients experienced secondary recurrence or disea...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Coronary Event Analysis in Breast Cancer Patients Who Received Breast-Conserving Surgery and Post-Operative Radiotherapy: a Korean Nationwide Cohort Study.
Authors: Sung SY, Lee JH, Yang KH, Seo Y, Kang MY Abstract Purpose: Adjuvant breast radiotherapy (RT) following breast-conserving surgery (BCS) has been reported to induce cardiac toxicity in breast cancer patients. We investigated the incidence and risk factors of major coronary events after breast RT using Korean nationwide Health Insurance Review and Assessment data. Methods: Using data from a nationwide quality assessment of breast cancer treatment, we identified 3,251 patients who received breast RT after BCS in 2013. Data about major coronary events were additionally collected from national claims data. W...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Concordance of Programmed Death-Ligand 1 Expression between SP142 and 22C3/SP263 Assays in Triple-Negative Breast Cancer.
Conclusion: This study demonstrates that although the 22C3 assay at a 1% cut-off value compared with the PD-L1 SP142 assay at the clinically relevant cut-off shows comparable but not interchangeable analytical performance, the analytical performance of the SP263 assay at a 1% cut-off value shows interchangeable performance with the PD-L1 SP142 assay at the clinically relevant cut-off. PMID: 32595992 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06).
Authors: Kim K, Jung J, Shin KH, Kim JH, Chang JH, Kim SS, Kim H, Park W, Kim YB, Chang JS Abstract The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. All patients underwent breast-conserving surgery followed by whole-breast irradiation; only 2 patients received regional nodal irradiation (RNI). The RS was 25 in 43. Sixty-two patients received adj...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Cutaneous Scalp Metastases of Malignant Phyllodes Tumor of the Breast.
Authors: Lee HJ, Lim HS, Ki SY, Lee JE, Lee JS, Park MH Abstract Phyllodes tumor (PT) of the breast is a relatively rare fibroepithelial tumor that accounts for
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Anastomosing Hemangioma of the Breast: An Unusual Case at an Unusual Site.
We report a case of AH in a 49-year-old woman presenting as a mass in the breast, a site which, to the best of our knowledge, has not been previously documented in the English literature. Microscopic examination of the mass revealed a well-demarcated proliferation of anastomosing vascular spaces lined by bland endothelial cells, with focal hobnailing and scattered intravascular fibrin thrombi. No mitotic activity was observed and the Ki-67 proliferative index was low. These features were interpreted as AH, a lesion that may be difficult to distinguish from low-grade angiosarcoma or other benign vascular lesions of the brea...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Breast Cancer Statistics in Korea in 2017: Data from a Breast Cancer Registry.
This article describes the breast cancer statistics in Korea, including the incidence, type of surgical procedure, stage, and molecular subtype, using the Korean Breast Cancer Society (KBCS) and Korea Central Cancer Registry data. There were a total of 26,534 new breast cancer diagnoses in 2017 in Korea, of which 4,139 were carcinoma in situ cases and 22,395 were invasive cancer cases. The age standardized rate of breast cancer was 75.3 per 100,000 women in 2017 (63.0 of invasive carcinoma and 12.3 of carcinoma in situ), and it has been steadily increasing across all age groups. Breast cancer occurred most commonly in the ...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Role of Long Noncoding RNAs in Antiestrogen Resistance in Breast Cancer: An Overview and Update.
Authors: Huang L, Liang G, Zhang Q, Zhao W Abstract As a standard treatment, endocrine therapy has dramatically enhanced the prognosis of patients with estrogen receptor (ER)-positive breast cancer, which accounts for nearly 70% of all breast cancers. Antiestrogen drugs such as tamoxifen and aromatase inhibitors are the standard treatment options for ERα-positive breast cancer. However, acquired antiestrogen resistance is still the leading cause of disease recurrence and progression. Evidence has shown that long noncoding RNAs (lncRNAs) play an essential role in the development of antiestrogen resistance in E...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Myeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling.
Conclusion: CCL3 promoted the growth of breast cancer cells, and MDSCs recruited by CCL3 interacted with these cells and then activated the PI3K-Akt-mTOR pathway, which led to EMT and promoted the migration and invasion of the cells. PMID: 32395374 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers.
Conclusion: CDK2 kinase activity was significantly upregulated in basal breast cancer tumors and was negatively correlated with p27 protein levels in the TCGA breast cancer dataset, suggesting that targeting CDK2 may be an effective treatment strategy for TNBC patients. PMID: 32395375 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinical Significance of C-X-C Motif Chemokine Receptor 4 and Integrin αvβ6 Expression in Breast Cancer.
In this study, we investigated the expression of CXCR4 and integrin αvβ6 in BC tissues and their correlation with clinicopathological characteristics, including survival. Methods: CXCR4 and αvβ6 expression in 111 BC tissues was examined by immunocytochemistry. Correlations between the expression of the 2 proteins and patient clinicopathological characteristic were investigated using the Kaplan-Meier method and the Cox proportional hazards model. Results: CXCR4 and αvβ6 were overexpressed in BC tissue compared with normal breast tissue. Overexpression of both molecules was related to...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Role of Androgen Receptor Expression in Surgically Resected Early Breast Cancer Patients.
Conclusion: We propose a cut-off value of 35% to best predict RFS in patients with surgically resected breast cancer. AR expression was positive in 68.4% of patients, and AR positivity was found to be an independent prognostic factor for longer RFS. PMID: 32395377 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Cervical Lymph Node Involvement above the Supraclavicular Fossa in Breast Cancer: Comparison with Stage IIIC (KROG 18-02).
Conclusion: The comparable clinical outcomes indicate that patients with breast cancer who have ipsilateral CLN metastasis without other distant metastasis may benefit from locoregional treatment of the ipsilateral breast and systemic therapies, as do those with N3c disease. PMID: 32395378 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Pro-inflammatory Cytokine Levels and Cancer-related Fatigue in Breast Cancer Survivors: Effects of an Exercise Adherence Program.
Conclusion: The BLESS intervention improved CRF in BCS immediately at post-intervention, and this study presents clinical feasibility for the management of CRF in BCS in the early survivorship phase who are already experiencing fatigue. PMID: 32395379 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

ESR1 Mutation Detection and Dynamics in Meningeal Carcinomatosis in Breast Cancer.
Authors: Carausu M, Melaabi S, Pierga JY, Bidard FC, Cabel L Abstract ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutation in plasma has been demonstrated as a prognostic and predictive factor for poor outcomes in subsequent AI therapy. In this case report, for the first time, we describe the detection of ESR1 mutation (p.Tyr537Ser) only in the cerebro...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Recurrence of Breast Carcinoma as Paget's Disease of the Skin along the Core Needle Biopsy Tract after Skin-Sparing Mastectomy.
We report a case of recurrence as Paget's disease at the core needle biopsy (CNB) entry site in a patient with microinvasive ductal carcinoma who underwent nipple-areola-skin sparing mastectomy (NASSM) and autologous reconstruction. Clinically diagnosed recurrences associated with previous needle procedures for malignant breast lesions are rare and usually occur in patients who have not received radiation therapy. The present case involved local recurrence at the skin puncture site of a patient diagnosed based on CNB findings who underwent NASSM without receiving radiation therapy. Although the removal of the CNB tract wit...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer.
Authors: Lei C, Yang C, Xia B, Ji F, Zhang Y, Gao H, Xiong Q, Lin Y, Zhuang X, Zhang L, Zhu T, Cheng M, Yang M, Wang K Abstract [This corrects the article on p. 47 in vol. 23, PMID: 32140269.]. PMID: 32395382 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: c-Myc-Induced Long Non-Coding RNA Small Nucleolar RNA Host Gene 7 Regulates Glycolysis in Breast Cancer.
Authors: Zhang L, Fu Y, Guo H Abstract [This corrects the article on p. 533 in vol. 22, PMID: 31897328.]. PMID: 32395383 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Matrix Metallopeptidase 3 Polymorphisms: Emerging genetic Markers in Human Breast Cancer Metastasis.
Authors: Suhaimi SA, Chan SC, Rosli R Abstract Matrix metallopeptidase 3 or MMP3, is a zinc-dependent proteolytic enzyme that is involved in various physiological processes via modification of the extracellular matrix. In particular, its over-expression has been associated with cancer metastasis and tumor growth in various cancers including breast cancer. MMP3 gene expression is regulated by several factors such as DNA polymorphisms which also serve as risk factors for breast cancer. As such, DNA polymorphisms of MMP3 have the potential to be utilized as genetic biomarkers for prediction and prognosis of metastatic...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Predicting the Benefit of Adjuvant Aromatase Inhibitor Therapy in Postmenopausal Breast Cancer Patients with Phosphorylated S6K1 Expression Status.
This study aimed to investigate the potential of pS6K1 as a predictive marker of adjuvant aromatase inhibitor (AI) therapy outcome in postmenopausal or ovarian function-suppressed patients with hormone-sensitive breast cancer. Methods: Medical records were retrospectively reviewed in postmenopausal or ovarian function-suppressed patients with estrogen receptor-positive and node-positive primary breast cancer. pS6K1 expression status was scored on a scale from 0 (negative) to 3+ (positive) based on immunohistochemical analysis. Results: A total of 428 patients were eligible. The median follow-up duration was 44 mont...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1.
Conclusion: Our findings demonstrated that PA directly bound to CtBP1 and inhibited the growth and migration of breast cancer cells through CtBP1 inhibition. Structural modifications of PA are further required to enhance its binding affinity and selectivity for CtBP1. PMID: 32140267 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Downregulation of N-myc and STAT Interactor Protein Predicts Aggressive Tumor Behavior and Poor Prognosis in Invasive Ductal Carcinoma.
Authors: Choi JE, Hyun CL, Jin MS, Lee KM, Moon JH, Ryu HS Abstract Purpose: We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. The expression levels and prognostic significance of NMI were also analyzed according to the molecular subgroup of breast cancers. Methods: Human NMI detection by immunohistochemistry was performed using tissue microarrays of 382 invasive ductal carcinomas. The correlation of NMI expression with patient clinicopathological parameters and prognostic sig...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research