Knockdown of Chloride Channel-3 Inhibits Breast Cancer Growth In Vitro and In Vivo.
Conclusion: Together, our data suggest that upregulation of ClC-3 by IGF-1 contributes to cell proliferation and tumor growth in breast cancer, and ClC-3 deficiency suppresses cell proliferation and tumor growth via the IGF/IGF receptor/ERK pathway. PMID: 29963105 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Histone Deacetylase-3 Modification of MicroRNA-31 Promotes Cell Proliferation and Aerobic Glycolysis in Breast Cancer and Is Predictive of Poor Prognosis.
Conclusion: Our findings revealed that HDAC3 served as an oncogene that could promote cell proliferation and aerobic glycolysis and was predictive of a poor prognosis in breast cancer. HDAC3 participated in the cell proliferation of breast cancer, which may prove to be a pivotal epigenetic target against this devastating disease. PMID: 29963106 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer.
In this study, we aimed to evaluate lymphocyte-activation gene-3 (LAG-3) expression and its prognostic value in neoadjuvant-treated triple-negative breast cancer (TNBC). Methods: LAG-3, programmed death-1 (PD-1), programmed death ligand-1 (PD-L1), and CD8+ tumor-infiltrating lymphocyte (TILs) levels were examined using immunohistochemistry in 148 preand 114 post-neoadjuvant chemotherapy (NACT) specimens of human TNBC tissue. Correlations between expression levels and clinicopathological features were analyzed. Prognostic values for combined detection in TNBC following NACT were evaluated. Results: In pre-NACT speci...
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy.
Conclusion: Most Korean patients with breast cancer showed vitamin D deficiency at diagnosis and a significant decrease in the serum concentration after NCT. No association with oncologic outcomes was found. Therefore, although optimal management for vitamin D deficiency is urgent for skeletal health, further research is warranted to clearly determine the prognostic role of vitamin D in patients with breast cancer who are candidates for NCT. PMID: 29963108 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Combined Let-7a and H19 Signature: A Prognostic Index of Progression-Free Survival in Primary Breast Cancer Patients.
Conclusion: Our results suggest that the combined let-7a and H19 signature is a novel prognostic factor for breast cancer patients treated with neoadjuvant chemotherapy. PMID: 29963109 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Efficiency of Cytokine-Induced Killer Cells in Combination with Chemotherapy for Triple-Negative Breast Cancer.
Conclusion: The data suggested that CIK cell immunotherapy improved the efficiency of regular chemotherapy in patients with TNBC, and the side effects of CIK cell immunotherapy were mild. PMID: 29963110 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Interactions between Alcohol Consumption and Adjuvant Hormone Therapy in Relation to Breast Cancer-Free Survival.
Conclusion: Associations of alcohol consumption with breast cancer-free survival are similar in women with and without adjuvant hormone therapy. Future studies are warranted to elucidate potential mechanisms underlying the observed inverse associations. PMID: 29963111 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Genetic Variants Associated with Clinicopathological Profiles in Sporadic Breast Cancer in Sri Lankan Women.
Conclusion: The common genetic variants identified in the AKT1, BRCA1, BRCA2, CCND1, CDH1, and NQO2 genes could serve as potential clinical and prognostic biomarkers in sporadic breast cancer patients. Further studies are required to validate our current findings in other populations. PMID: 29963112 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Validation of the American Joint Committee on Cancer 8th Staging System in 24,014 Korean Patients with Breast Cancer.
Conclusion: Our data suggests that the prognostic staging system provides superior prognostic value to the anatomic staging system in Korean patients with breast cancer. PMID: 29963113 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Assessment of Quality of Life and Safety in Postmenopausal Breast Cancer Patients Receiving Letrozole as an Early Adjuvant Treatment.
Authors: Jung Y, Lee SJ, Lee J, Noh WC, Nam SJ, Park BW, Bae YT, Kang SS, Park HK, Yoon JH, Kim JR, Cho SH, Kim LS, Moon BI, Jung SH, Lim CW, Kim SY, Park HY, Song J, Lee KM, Park SH, Jeong J, Park HL, Kim SW, Kwak BS, Kang SH, Cho YU, Gwak GH, Park YL, Kim SW, Han S Abstract Purpose: There are few reports from Asian countries about the long-term results of aromatase inhibitor adjuvant treatment for breast cancer. This observational study aimed to evaluate the long-term effects of letrozole in postmenopausal Korean women with operable breast cancer. Methods: Self-reported quality of life (QoL) scores were seria...
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Ex Vivo Shear-Wave Elastography of Axillary Lymph Nodes to Predict Nodal Metastasis in Patients with Primary Breast Cancer.
Authors: Bae SJ, Park JT, Park AY, Youk JH, Lim JW, Lee HW, Lee HM, Ahn SG, Son EJ, Jeong J Abstract Purpose: There is still a clinical need to easily evaluate the metastatic status of lymph nodes during breast cancer surgery. We hypothesized that ex vivo shear-wave elastography (SWE) would predict precisely the presence of metastasis in the excised lymph nodes. Methods: A total of 63 patients who underwent breast cancer surgery were prospectively enrolled in this study from May 2014 to April 2015. The excised axillary lymph nodes were examined using ex vivo SWE. Metastatic status was confirmed based on the fin...
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Microinvasive Carcinoma versus Ductal Carcinoma In Situ: A Comparison of Clinicopathological Features and Clinical Outcomes.
Conclusion: Microinvasive carcinomas are distinct from DCIS in terms of clinicopathological features and biomarker expressions but are similar to DCIS in terms of clinical outcomes. Our results suggest that microinvasive carcinoma can be treated and followed up as pure DCIS. PMID: 29963116 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Which Patients with Left Breast Cancer Should be Candidates for Heart-Sparing Radiotherapy?
This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with left breast cancer. Methods: We identified 4,333 patients who received adjuvant RT following breast-conserving surgery for ductal carcinoma in situ or invasive breast cancer from 1996 to 2010. Incidence rates of cardiovascular disease were compared between left-sided and right-sided RT, and stratified by age and risk factors such as body mass index (BMI), smoking, hyperlipidemia, hypertension, diabetes, administration of a...
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Comparison of Outcomes between Direct-to-Implant Breast Reconstruction Following Nipple-Sparing Mastectomy through Inframammary Fold Incision versus Noninframammary Fold Incision.
Conclusion: IMF incision enables complete preservation of the nipple-areolar complex, yielding superior aesthetic results in immediate DTI breast reconstruction after NSM. The nature of incision used had no significant impact on postoperative complications or reoperation rates and had comparable oncologic safety to that of non-IMF incisions. IMF incisions produced the least visible scarring and did not affect breast shape. Most patients were satisfied with the aesthetic outcomes. PMID: 29963118 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Verification of a Western Nomogram for Predicting Oncotype DX ™ Recurrence Scores in Korean Patients with Breast Cancer.
Verification of a Western Nomogram for Predicting Oncotype DX™ Recurrence Scores in Korean Patients with Breast Cancer. J Breast Cancer. 2018 Jun;21(2):222-226 Authors: Kim JM, Ryu JM, Kim I, Choi HJ, Nam SJ, Kim SW, Yu J, Lee SK, Lee JE Abstract A recent study conducted at the University of Tennessee Medical Center using a large dataset from the National Cancer Database (NCDB) reported the use of nomograms for predicting Oncotype DX™ (ODX) scores with clinicopathologic data. We reviewed the data of 218 patients who underwent the ODX test at a single institution in Korea to confirm that nom...
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Apocrine Encapsulated Papillary Carcinoma of the Breast: The First Reported Case with an Infiltrative Component.
Authors: Kővári B, Ormándi K, Simonka Z, Vörös A, Cserni G Abstract Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive component. Herein, we report the 11th case of apocrine EPC, which had a conventional invasive carcinoma component and provides evidence of the malignant potential of this entity. We postulate that apocrine EPC is...
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Associations between Dietary Allium Vegetables and Risk of Breast Cancer: A Hospital-Based Matched Case-Control Study.
Authors: Pourzand A, Tajaddini A, Pirouzpanah S, Asghari-Jafarabadi M, Samadi N, Ostadrahimi AR, Sanaat Z Abstract [This corrects the article on p. 292 in vol. 19, PMID: 27721879.]. PMID: 29963121 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Development of a Nomogram to Predict N2 or N3 Stage in T1-2 Invasive Breast Cancer Patients with No Palpable Lymphadenopathy.
Authors: Kim I, Ryu JM, Kim JM, Choi HJ, Lee SK, Yu JH, Lee JE, Kim SW, Nam SJ Abstract [This corrects the article on p. 270 in vol. 20, PMID: 28970853.]. PMID: 29963122 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry.
Authors: Kang SY, Kim YS, Kim Z, Kim HY, Lee SK, Jung KW, Youn HJ, Korean Breast Cancer Society Abstract The Korean Breast Cancer Society (KBCS) has established a nationwide breast cancer database using an online registration program in 1996. The present study aimed to analyze the basic findings and trends of breast cancer in Korea in 2015 using the data provided by the Korea Central Cancer Registry and the KBCS. In 2015, a total of 22,550 patients were newly diagnosed with breast cancer, of which 3,331 were carcinoma in situ cases and 19,219 were invasive cancer cases. The incidence rate of breast cancer in Korea ...
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Isomangiferin, a Novel Potent Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor, Suppresses Breast Cancer Growth, Metastasis and Angiogenesis.
Conclusion: Our findings demonstrate that isomangiferin exerts anti-breast cancer effects via the functional inhibition of VEGFR-2. Pharmaceutically targeting VEGFR-2 by isomangiferin could be an effective therapeutic strategy for breast cancer. PMID: 29628979 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Berberine Suppresses Fibronectin Expression through Inhibition of c-Jun Phosphorylation in Breast Cancer Cells.
Conclusion: Our findings demonstrate that FN expression is regulated via an AP-1-dependent mechanism, and that BBR suppresses FN expression in TNBC cells through inhibition of AP-1 activity. PMID: 29628980 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Troglitazone Inhibits Matrix Metalloproteinase-9 Expression and Invasion of Breast Cancer Cell through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism.
Conclusion: Troglitazone inhibited nuclear factor κB and activator protein-1-mediated MMP-9 expression and invasion of MCF-7 cells through a PPARγ-dependent mechanism. PMID: 29628981 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Endocrine Treatment-Related Symptoms and Patient Outcomes in Breast Cancer: A Meta-Analysis.
Conclusion: Endocrine treatment-related symptoms are significantly predictive of lower recurrence rate in breast cancer patients, regardless of the type of symptoms, time-point of evaluation, or inclusion of baseline symptoms. These symptoms could be biomarkers for the prediction of long-term responses to endocrine treatment in patients with breast cancer. PMID: 29628982 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

FcrR3A-158 Polymorphism and Stromal Tumor-Infiltrating Lymphocytes and Survival among Patients with Metastatic HER2-Positive Breast Cancer Receiving Trastuzumab-Based Treatment.
Conclusion: High sTIL expression may be associated with better efficacy of trastuzumab-containing therapy in patients with metastatic HER2-positive breast cancer. However, this finding warrants further evaluation in the larger population. PMID: 29628983 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinicopathologic and Prognostic Significance of the Zinc Finger of the Cerebellum Family in Invasive Breast Cancer.
Authors: Han W, Zhang C, Gao XJ, Wang HB, Chen F, Cao F, Hu YW, Ma J, Gu X, Ding HZ Abstract Purpose: Five members of the zinc finger of the cerebellum (ZIC) family-ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5-have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and ...
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinical Characteristics and Prognosis Associated with Multiple Primary Cancers in Breast Cancer Patients.
Conclusion: MPCs were a poor prognostic factor for patients with breast cancer. Two or more MPCs and a shorter time interval between occurrences were worse prognostic factors. Although MPCs were a poor prognostic factor, thyroid cancer did not affect the prognosis of patients with breast cancer. PMID: 29628985 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Chronological Improvement in Survival of Patients with Breast Cancer: A Large-Scale, Single-Center Study.
This study aimed to chronologically evaluate survival of patients with breast cancer in Korea and investigate the observed changes during the last 20 years. We also sought to determine factors that may influence outcomes and changes in the duration of survival over time. Methods: We retrospectively analyzed a total of 10,988 patients with breast cancer who were treated at our institution between January 1993 and December 2008. We divided the study period into three periods (P1, 1993-1997; P2, 1998-2002; and P3, 2003-2008). We retrospectively reviewed the collected data from the Asan database, including age at diagnosis...
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Benign Intraductal Papilloma without Atypia on Core Needle Biopsy Has a Low Rate of Upgrading to Malignancy after Excision.
Conclusion: The rate of upgrading to malignancy for benign IDP without atypia was very low, suggesting that close clinical and radiologic observation may be sufficient for patients with benign IDP without atypia on CNB under proper settings. PMID: 29628987 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Identification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer.
Authors: Chung JM, Jung Y, Kim YP, Song J, Kim S, Kim JY, Kwon M, Yoon JH, Kim MD, Lee JK, Chung DY, Lee SY, Kang J, Kang HC Abstract Triple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of death due to cancer among women. Currently, however, no diagnostic blood-based biomarker exists to identify the early stages of TNBC. To address this point, we utilized a human protein microarray system to identify serum autoantibodies that showed different expression patterns between TNBC and normal serum samples, ...
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Breast Cancer Epidemiology of the Working-Age Female Population Reveals Significant Implications for the South Korean Economy.
In this study, we aimed to evaluate the economic loss due to the diagnosis of breast cancer within the female South Korean working-age population. A population-based cost analysis was performed for cancer-related diagnoses between 1999 and 2014, using respective public government funded databases. Among the five most common cancers, breast cancer mortality was strongly associated with the growth in gross domestic product between 1999 and 2014 (R=0.98). In the female population, breast cancer represented the greatest productivity loss among all cancers, which was a consequence of the peak in the incidence of breast cancer d...
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Malignant Melanoma of the Nipple: A Case Report.
Authors: Nagata Y, Yoshioka M, Uramoto H, Tsurudome Y, Yamada S, Hanagiri T, Tanaka F Abstract Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy. We herein report a patient who underwent surgical resection of a primary malignant melanoma of the nipple. An elastic soft nodule was observed on the left nipple, and no abnormal lesions were identified in t...
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Retraction note to: Lentivirus-Mediated Short-Hairpin RNA Targeting Protein Phosphatase 4 Regulatory Subunit 1 Inhibits Growth in Breast Cancer.
Authors: Qi Y, Hu T, Lin K, Ye R, Ye Z Abstract [This retracts the article on p. 218 in vol. 18, PMID: 26472971.]. PMID: 29628991 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 11, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Biomarkers of Everolimus Sensitivity in Hormone Receptor-Positive Breast Cancer.
Authors: Yi Z, Ma F Abstract Activation of the mammalian target of rapamycin (mTOR) signaling pathway is an important mechanism of resistance to endocrine therapy in breast cancer. Everolimus, an mTOR inhibitor, has been shown to increase the efficacy of endocrine therapy and overcome resistance to endocrine therapies. Clinical studies have suggested that everolimus combined with endocrine therapy prolongs progression-free survival in hormone receptor-positive breast cancer patients. However, because breast cancer includes a group of highly heterogeneous tumors, patients may have different responses to everolimus. ...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Selective Radiation Therapy for Ductal Carcinoma In Situ Following Breast-Conserving Surgery According to Age and Margin Width: Korean Radiation Oncology Group 11-04 and 16-02 Studies.
Authors: Kim K, Kim JH, Kim YB, Suh CO, Shin KH, Kim JH, Kim TH, Jung SY, Choi DH, Park W, Ahn SD, Kim SS, Yea JW, Kang MK, Kim DW, Kim YJ Abstract Purpose: The optimal indications for omitting adjuvant radiation therapy (RT) after breast-conserving surgery are still controversial in ductal carcinoma in situ (DCIS) of the breast. The purpose of this study was to validate the role of postoperative RT in DCIS patients aged ≤50 years and with tumor margin widths of
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Interactions of Family History of Breast Cancer with Radiotherapy in Relation to the Risk of Breast Cancer Recurrence.
Conclusion: Radiotherapy for a primary breast cancer in women with a family history of breast cancer does not increase risk of breast cancer recurrence. If these findings are replicated in future studies, the results may translate into an important health message for breast cancer survivors with a family history of breast cancer. PMID: 29285037 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

A Multicenter Phase II Trial of Neoadjuvant Chemotherapy with Docetaxel and Gemcitabine in Locally Advanced Breast Cancer.
Conclusion: The combination of docetaxel and gemcitabine did not improve pCR. However, this regimen has shown potential as a NAC by producing a reasonable rate of breast-conserving surgery and favorable responses in patients with locally advanced breast cancer. The therapeutic efficacy of this regimen will be determined in additional trials to overcome the limitations of the current study. PMID: 29285038 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Cyclophosphamide, Methotrexate, and 5-Fluorouracil as Palliative Treatment for Heavily Pretreated Patients with Metastatic Breast Cancer: A Multicenter Retrospective Analysis.
Conclusion: CMF therapy is effective and tolerable as salvage treatment for heavily pretreated MBC. PMID: 29285039 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Tamoxifen and the Risk of Parkinson's Disease in Female Patients with Breast Cancer in Asian People: A Nationwide Population-Based Study.
Conclusion: Tamoxifen treatment may increase the risk of PD in Taiwanese female patients with breast cancer more than 6 years after the initiation of treatment. PMID: 29285040 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Wnt7a Deficiency Could Predict Worse Disease-Free and Overall Survival in Estrogen Receptor-Positive Breast Cancer.
This study aimed to detect the level of Wnt7a expression in breast cancer and explore its role in the disease progression and prognosis. Methods: A total of 258 patients diagnosed with invasive ductal carcinoma of the breast were included in this study. Using tissue microarray and immunohistochemical staining, we evaluated the association between Wnt7a expression and clinicopathological parameters, and the prognostic value of Wnt7a. Results: Wnt7a expression was significantly correlated with estrogen receptor (ER) expression (odds ratio, 3.95; 95% confidence interval [CI], 1.99-7.80; p
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Treatment Patterns and Outcomes in Elderly Patients with Metastatic Breast Cancer: A Multicenter Retrospective Study.
Conclusion: Elderly patients with MBC should not be excluded from receiving standard treatments prescribed for younger patients. Future research plans for elderly patients, especially aged ≥75 years with breast cancer, should include a geriatric assessment for identifying individuals at risk for treatment-related toxicity. Overall, this analysis will provide a better understanding of this population and help guide clinical care in real-world practice. PMID: 29285042 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Improved Model for Predicting Axillary Response to Neoadjuvant Chemotherapy in Patients with Clinically Node-Positive Breast Cancer.
Conclusion: Tumor response rate was the most significant independent predictor of axillary pCR in response to NAC. The model that included tumor response rate was a significantly better predictor of axillary pCR than the model that excluded tumor response rate. PMID: 29285043 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Metabolic Activity of Normal Glandular Tissue on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: Correlation with Menstrual Cycles and Parenchymal Enhancements.
Authors: An YS, Jung Y, Kim JY, Han S, Kang DK, Park SY, Kim TH Abstract Purpose: The aims of our study were to correlate the degree of metabolic activity in normal glandular tissue measured on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) with qualitative background parenchymal enhancement (BPE) grades on magnetic resonance imaging (MRI), and to investigate the change in standardized uptake value (SUV) according to the patients' menstrual cycles. Methods: From January 2013 to December 2015, 298 consecutive premenopausal patients with breast cancer who underwent both b...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Optimization of RNA Extraction from Formalin-Fixed Paraffin-Embedded Blocks for Targeted Next-Generation Sequencing.
Conclusion: Archived FFPE tissues can be used to extract RNA for NGS if they are properly processed before fixation. The expected amount of RNA per unit size calculated in this study will be useful for other researchers. PMID: 29285045 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Practice Patterns and Perceptions of Korean Surgeons Regarding Margin Status after Breast-Conserving Surgery.
Authors: Yoo TK, Kim SW, Kang E, Ahn SG, Hwang KT, Kim SK, Woo SU, Shin HJ, Song YJ, Jung EJ, Chang MC, Lee I, Park WC, Korean Breast Cancer Society Abstract Two consecutive surveys for breast surgeons in Korea were conducted to comprehend the practice patterns and perceptions on margin status after breast-conserving surgery. The surveys were conducted online in 2014 (initial) and 2016 (follow-up). A total of 126 and 88 responses were obtained in the initial and follow-up survey, respectively. More than 80% of the respondents replied to routinely apply frozen section biopsy for intraoperative margin assessment in b...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Ectopic Male Breast Cancer in the Perineum: A Case Report.
Authors: Eom HJ, Ko BS, Song IH, Gong G, Kim HH Abstract Ectopic breast tissue and male breast cancer are both very rare diseases with only a few reports in the literature. Here, we present the first case of ectopic male breast cancer in the perineum. The patient was a 70-year-old man with a palpable mass in the perineum. A wide local excision and inguinal lymph node dissection revealed invasive breast carcinoma of no special type involving the skin and subcutis, and inguinal lymph node metastases. Immunohistochemical staining showed that the tumor cells were strongly positive for estrogen and progesterone receptor...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Follow-up Outcomes of Benign Pathology Initially Assigned as Breast Imaging Reporting and Data System Category 4A and 3.
Authors: You JY, Suh HJ, Kim Y, Jun JK, Ojeda-Fournier H, Ko K Abstract [This corrects the article on p. 304 in vol. 20, PMID: 28970857.]. PMID: 29285048 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Sentinel Lymph Node Biopsy in Breast Cancer: A Clinical Review and Update.
This article discusses how sentinel lymph node biopsy has evolved and is becoming a useful tool in new clinical scenarios of breast cancer management. PMID: 28970846 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Meeting Highlights: The Second Consensus Conference for Breast Cancer Treatment in Korea.
Discussions on radiotherapy addressed the need for adjuvant radiotherapy and radiation field of regional lymph node in the context of various N1 breast cancer cases. The participants reached a consensus to recommend that N1 patients should receive regional nodal irradiation for a large tumor burden (e.g., three positive nodes, perinodal extension, or large primary tumor). Finally, the panels favored OFS in addition to endocrine therapy for premenopausal women with high risk factors such as a large tumor size, involvement of more than three nodes, and a high histologic grade. PMID: 28970847 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells.
CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C δ/p38/c-Jun N-terminal kinase/AP-1 pathway. Therefore, CFE could restrict breast cancer invasiveness owing to its ability to inhibit MMP-9 activity. PMID: 28970848 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Gene Regulatory Network Analysis for Triple-Negative Breast Neoplasms by Using Gene Expression Data.
CONCLUSION: Our TNBN gene regulatory network was a scale-free one, which means that the network would be easily destroyed if the hub vertices were attacked. Thus, it is important to identify the hub vertices in the network analysis. In the TNBN gene regulatory network, ZDHHC20 and RAPGEF6 were found to be oncogenes. Further study of these genes could help to reveal a novel method for treating TNBN in the future. PMID: 28970849 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research