Insights into Hypoxia: Non-invasive Assessment through Imaging Modalities and Its Application in Breast Cancer.
Authors: Daimiel I Abstract Oxygen is crucial to maintain the homeostasis in aerobic cells. Hypoxia is a condition in which cells are deprived of the oxygen supply necessary for their optimum performance. Whereas oxygen deprivation may occur in normal physiological processes, hypoxia is frequently associated with pathological conditions. It has been identified as a stressor in the tumor microenvironment, acting as a key mediator of cancer development. Numerous pathways are activated in hypoxic cells that affect cell signaling and gene regulation to promote the survival of these cells by stimulating angiogenesis, sw...
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway.
Authors: Liang Y, Wang S, Liu J Abstract Purpose: Tumor protein p53-regulated apoptosis-inducing protein 1 (TP53AIP1) functions in various cancers. We studied the effect and molecular mechanism of TP53AIP1 in breast cancer. Methods: The degree of correlation between TP53AIP1 expression and overall survival in patients with breast cancer was obtained from the online The Cancer Genome Atlas database. Six of the TP53AIP1 levels in the tumor and adjacent non-tumor tissues randomly selected from 38 breast cancer patients were determined. Transgenic technology was used to enhance the expression of TP53AIP1 in breast ...
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Doxorubicin Promotes Migration and Invasion of Breast Cancer Cells through the Upregulation of the RhoA/MLC Pathway.
Conclusion: Doxorubicin activates the RhoA/MLC pathway and enhances breast cancer cell migration and invasion. Therefore, this pathway might be explored as a therapeutic target to suppress anthracycline-enhanced tumor progression. PMID: 31281722 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Inhibition of Indoleamine 2,3-Dioxygenase Enhances the Therapeutic Efficacy of Immunogenic Chemotherapeutics in Breast Cancer.
Conclusion: Compared to single agent therapy, combination of NLG919 with DOX demonstrated better therapeutic effects in 4T1 murine breast tumor model. IDO inhibition by NLG919 enhanced the therapeutic efficacy of DOX in breast cancer, achieving synergistic effect. PMID: 31281723 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Correlation between IL-1 β-C31T Gene Polymorphism and Susceptibility to Breast Cancer.
Conclusion: The IL-1β-C31T polymorphism affects breast cancer susceptibility, especially in women with late age at first birth, high BMI, postmenopausal status, negative smoking history, and invasive ductal carcinoma. Our study adds to the evidence about the importance of IL-1β-C31T polymorphism in breast cancer susceptibility. PMID: 31281724 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

miR-148b-3p, miR-190b, and miR-429 Regulate Cell Progression and Act as Potential Biomarkers for Breast Cancer.
Authors: Dai W, He J, Zheng L, Bi M, Hu F, Chen M, Niu H, Yang J, Luo Y, Tang W, Sheng M Abstract Purpose: Breast cancer is the most frequently diagnosed malignancy in women worldwide. MicroRNAs (miRNAs) are thought to serve as potential biomarkers in various cancers, including breast cancer. Methods: We evaluated the miRNA expression profiles in 1,083 breast cancer samples and 104 normal breast tissues from The Cancer Genome Atlas database. We used the edgeR package of R software to analyze the differentially expressed miRNAs in normal and cancer tissues, and screened survival-related miRNAs by Kaplan-Meier an...
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Cell Division Cycle Associated 8 Is a Key Regulator of Tamoxifen Resistance in Breast Cancer.
Conclusion: In this study, we reported that CDCA8 is a key regulator of tamoxifen resistance in BC, suggesting that CDCA8 may serve as a potential therapeutic target for BC treatment. PMID: 31281726 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

High Survivin and Low Zinc Finger of the Cerebellum 1 Expression Indicates Poor Prognosis in Triple-negative Breast Carcinoma.
Authors: Shi CT, Ma J, Shi QF, Zhang Y, Wang HN Abstract Purpose: Triple-negative breast carcinoma (TNBC) is accompanied with high risk of metastasis and recurrence. The present study aimed to explore the clinicopathological and prognostic roles of putative tumor-related genes in patients with TNBC. Methods: Thirty pairs of frozen-thawed tumors were used to select reliable indicators via real-time quantitative polymerase chain reaction (RT-qPCR). Then, 150 pathology specimens were used to evaluate the expression of proteins in TNBC through immunohistochemistry. In addition, Kaplan-Meier curves and Cox regressio...
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Validation of a Risk Score Incorporating Tumor Characteristics into the American Joint Committee on Cancer Anatomic Stage for Breast Cancer.
Conclusion: The RSS is comparable to the AJCC8 PS for a patient population receiving chemotherapy as well as endocrine- and HER2-targeted therapy and further stratifies stage IV patients. PMID: 31281728 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Murine Model Study of a New Receptor-Targeted Tracer for Sentinel Lymph Node in Breast Cancer.
Conclusion: ICG-rituximab localized to the SLN without imaging from the secondary or tertiary LNs within 6 hours. The optimal ICG dose was 0.12 μg, and the optimal interval for SLN detection was 34 minutes to 6 hours post-injection. This novel receptor-targeted tracer is of great value to clinical research and application. PMID: 31281729 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Benefit of Post-Mastectomy Radiotherapy in ypN0 Patients after Neoadjuvant Chemotherapy According to Molecular Subtypes.
Conclusion: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype. PMID: 31281730 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Comparative Analysis of Outcomes and Clinicopathological Characteristics of Synchronous and Metachronous Contralateral Breast Cancer: A Study of the SEER Database.
Conclusion: The characteristics and outcomes of sCBCs and mCBCs were substantially different. sCBC and mCBC patients may have different prognosis, and the prognosis of CBC depends on the first and second tumors. PMID: 31281731 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Comparison of Digital and Screen-Film Mammography for Breast-Cancer Screening: A Systematic Review and Meta-Analysis.
Conclusion: The breast-cancer screening performance of DM is similar to that of SFM. The diagnostic performance of DM depends on the study design, and, in terms of performance, full-field DM is superior to SFM, unlike computed radiography systems. PMID: 31281732 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Solitary Fibrous Tumor of Breast with Anaplastic Areas (Malignant Solitary Fibrous Tumor): A Case Report with Review of Literature.
Authors: Jung MJ, Alrahwan D, Dubrovsky E, Baek D, Ayala AG, Ro JY Abstract Solitary fibrous tumor (SFT) is a rare, soft tissue neoplasm that rarely presents in breast tissue, with only 27 previously reported cases. To our knowledge, only one case of malignant SFT has been reported in the English literature. A 75-year-old Caucasian woman presented to our institution with a 3-month history of a palpable left breast mass. No other symptoms, including nipple discharge or skin changes, were noted. She underwent 3 previous biopsies for right breast masses, all of which were benign, with no evidence of spindle cell neopl...
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Human Epidermal Growth Factor Receptor 2-positive Mucinous Carcinoma with Signet Ring Cell Differentiation, Which Showed Complete Response after Neoadjuvant Chemotherapy.
Authors: Jang Y, Cho EY, Cho SY Abstract Mucinous carcinoma (MC) is a rare subtype of breast cancer, which is composed of tumor cells floating in the abundant extracellular mucin. This form of cancer is usually estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor 2 (HER2) negative. Here, we present a case of HER2-positive MC with an unusual signet ring cell differentiation. It is very rare that a breast tumor consists entirely of signet ring cells. The tumor showed pathologic complete response (pCR) after neoadjuvant chemotherapy with trastuzumab and pertuzumab. pCR of HER2-po...
Source: Journal of Breast Cancer - July 11, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers.
In conclusion, the impact of these concepts on the formation of hormone-sensitive and -insensitive breast tumors is outlined. PMID: 30941229 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1.
Conclusion: We demonstrated that Pokemon binds to SP1 to down-regulate Smad4 expression, thereby promoting proliferation of breast cancer cells. This suggests that Pokemon is a potential TGFβ-signaling participant in breast cancer progression. PMID: 30941230 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Circulating Plasmacytoid and Myeloid Dendritic Cells in Breast Cancer Patients: A Pilot Study.
Conclusion: An increase of pDCs in the peripheral blood of breast cancer patients was observed and patients with HER-2 positive breast cancer had higher levels of circulating pDCs than did HER-2 negative patients. Our results suggest that expression of DCs can differ according to breast cancer subtype and indicate that, with further investigation, DC expression has the possibility of being presented as a prognostic factor. PMID: 30941231 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Tumor-Associated Macrophages as Potential Prognostic Biomarkers of Invasive Breast Cancer.
Conclusion: TAMs, including M2 type, are associated with tumor progression in IBC. They can also act as a significant unfavorable or favorable prognostic factor. In addition to simply analyzing the degree of TAM infiltration, it is also important to analyze the location of TAMs. PMID: 30941232 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Screening of Recurrence Related MicroRNA in Ductal Carcinoma In Situ and Functional Study of MicroRNA-654-5p.
This study analyzed the clinicopathological features and screened key microRNAs (miRNAs) contributing to local or distant recurrence. Methods: The clinicopathological features of DCIS were evaluated and survival analysis were performed to clarify risk factors associated with poor prognosis. Using miRNA arrays and real-time quantitative polymerase chain reaction (RT-qPCR) on DCIS formalin-fixed and paraffin-embedded samples with or without microinvasion with different clinical outcomes, potential DCIS metastasis-related miRNAs were screened out and further validated. The influence of one identified miRNA, miRNA-654-5p, ...
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Determining Whether High Nodal Burden in Early Breast Cancer Patients Can Be Predicted Preoperatively to Avoid Sentinel Lymph Node Biopsy.
Authors: Lim GH, Teo SY, Allen JC, Chinthala JP, Leong LCH Abstract Purpose: The Z0011 trial showed that axillary lymph node dissection (ALND) can be safely avoided in breast cancer patients with low nodal burden (LNB). ALND can be performed in patients with high nodal burden (HNB). We aimed to determine whether HNB in early breast cancer patients can be predicted preoperatively to avoid sentinel lymph node biopsy (SLNB). Methods: Early invasive breast cancer patients (cT1-2cN0) were retrospectively reviewed. We excluded patients with neoadjuvant chemotherapy and incomplete data. The patients were divided into ...
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

CD9 Expression in Tumor Cells Is Associated with Poor Prognosis in Patients with Invasive Lobular Carcinoma.
Conclusion: CD9 expression in tumor cells could be a significant prognostic marker in patients with ILC. PMID: 30941235 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prescription Refill Gap of Endocrine Treatment from Electronic Medical Records as a Prognostic Factor in Breast Cancer Patients.
Conclusion: A gap of> 4 weeks in hormonal treatment has negative effects on breast cancer prognosis, and can hence be used as a sentinel index of higher risk due to treatment non-adherence. Further evaluation is needed to determine whether the gap can be used as a universal index for monitoring the adherence to hormonal treatment. PMID: 30941236 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Young Patients with Hormone Receptor-Positive Breast Cancer Have a Higher Long-Term Risk of Breast Cancer Specific Death.
Authors: Fu J, Zhong C, Wu L, Li D, Xu T, Jiang T, Yang J, Du J Abstract Purpose: Although it is widely accepted that hormone receptor (HR) status is associated with later post-diagnostic periods, a debate exists as to whether the association is independent of age. The aim of our study was to confirm the impact of HR status on later period breast cancer-specific death (LP-BCSD) and later period non-breast cancer-specific death (LP-non-BCSD) in different age subgroups. Methods: Surveillance, Epidemiology, and End Results databases were utilized to identify 181,108 breast cancer patients with> 5 years survival...
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Immediate Breast Reconstruction Does Not Have a Clinically Significant Impact on Adjuvant Treatment Delay and Subsequent Survival Outcomes.
Conclusion: IBR was associated with a modest increase in the duration from surgery to chemotherapy that was statistically but not clinically significant. Moreover, IBR had no influence on PMRT delay or survival outcomes, suggesting that it is an acceptable option for patients with non-metastatic breast cancer undergoing mastectomy. PMID: 30941238 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Central Nervous System Failure in Korean Breast Cancer Patients with HER2-Enriched Subtype: Korean Radiation Oncology Group 16-15 Multicenter Retrospective Study.
Conclusion: Adjuvant trastuzumab was associated with higher CNS failure rate in Korean patients with HER2-enriched breast cancer. Close monitoring and reasonable approaches such as CNS penetrating HER2 blockades combined with the current standard therapy could contribute to improving intracranial tumor control and quality of life in patients with CNS metastasis from HER2-enriched breast cancer. PMID: 30941239 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Whole Exome Sequencing in the Accurate Diagnosis of Bilateral Breast Cancer: a Case Study.
We report a rare case of synchronous BBC in a 61-year-old Chinese woman. Based on her clinical and pathological features and the use of whole exome sequencing and cancer genome analysis, we concluded that the patient developed contralateral metastatic breast cancer which metastasized from left to right. Therefore, together with clinical, pathological and cancer genomics information, we could precisely define the origin and evolution of BBC. PMID: 30941240 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Durable Response of Androgen Receptor-Positive Male Breast Cancer to Goserelin.
In this report, we describe a male patient with AR-positive TNBC who was successfully treated using an LHRH agonist after pretreatment with several lines of chemotherapy and achieved a durable response. We also review the existing evidence supporting LHRH- and AR-targeted therapy for this rare disease. PMID: 30941241 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Neoadjuvant Therapy Should Be the Standard of Care for Every Node Positive Breast Cancer Patient.
Authors: Hamdy O PMID: 30941242 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry.
Authors: Kang SY, Kim YS, Kim Z, Kim HY, Lee SK, Jung KW, Youn HJ, Korean Breast Cancer Society Abstract [This corrects the article on p. 1 in vol. 21, PMID: 29628978.]. PMID: 30941243 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 5, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Current Approaches in Development of Immunotherapeutic Vaccines for Breast Cancer.
Authors: Allahverdiyev A, Tari G, Bagirova M, Abamor ES Abstract Cancer is the leading cause of death worldwide. In developed as well as developing countries, breast cancer is the most common cancer found among women. Currently, treatment of breast cancer consists mainly of surgery, chemotherapy, hormone therapy, and radiotherapy. In recent years, because of increased understanding of the therapeutic potential of immunotherapy in cancer prevention, cancer vaccines have gained importance. Here, we review various immunotherapeutic breast cancer vaccines including peptide-based vaccines, whole tumor cell vaccines, gen...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis.
Authors: Han CC, Wan FS Abstract Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To accommodate the occurrence of ERS, cells have evolved a highly conserved, self-protecting signal transduction pathway called the unfolded protein response. Notably, ERS signaling is involved in the development of a variety of diseases and is closely related to tumor development, particularly in breast cancer. This review discusses recent research regarding associati...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Identification and Validation of Circulating MicroRNA Signatures for Breast Cancer Early Detection Based on Large Scale Tissue-Derived Data.
Conclusion: The present study established a novel and effective method to identify biomarkers for early breast cancer. And the method, is also suitable for other cancer types. Furthermore, a combination of three miRNAs was identified as a prospective biomarker for breast cancer early detection. PMID: 30607157 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer.
Conclusion: Our data indicated that the level of B7 family members can predict the prognosis of breast cancer patients, and miR-195/miR-497 regulate CD274 expression in triple negative breast cancer. This regulation may further influence tumor progression and the immune tolerance mechanism in breast cancer and may be able to predict the effect of immunotherapy on patients. PMID: 30607158 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

PIK3CA Mutations and Neoadjuvant Therapy Outcome in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: A Sequential Analysis.
Authors: Seo Y, Park YH, Ahn JS, Im YH, Nam SJ, Cho SY, Cho EY Abstract Purpose: PIK3CA mutation is considered to be a possible cause for resistance to neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. We investigated the association between PIK3CA mutations and the outcome of NAC in HER2-positive breast cancers. Methods: A total of 100 HER2-positive breast cancer patients who had undergone NAC and surgery between 2004 and 2016 were examined. Mutation status was sequentially assessed in pre-NAC, post-NAC, and recurrent specimens taken from these patients. ...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Shorter Telomere Length Is Associated with Increased Breast Cancer Risk in a Chinese Han Population: A Case-Control Analysis.
Conclusion: Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings. PMID: 30607160 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Significance of Vesicle-Associated Membrane Protein 8 Expression in Predicting Survival in Breast Cancer.
This study aimed to evaluate the clinical significance and biological function of VAMP8 in BC. Methods: A total of 112 BC samples and 30 normal mammary gland samples were collected. The expression of VAMP8 was assessed in both BC tissues and normal mammary gland tissues via a two-step immunohistochemical detection method. Results: The expression of VAMP8 in BC tissues was significantly higher than that in normal breast tissues. Furthermore, increased VAMP8 expression was significantly correlated with tumor size (p=0.007), lymph node metastasis (p=0.024) and recurrence (p=0.001). Patients with high VAMP8 expression ...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

T-Cell Immunoglobulin Mucin 3 Expression on Tumor Infiltrating Lymphocytes as a Positive Prognosticator in Triple-Negative Breast Cancer.
This study was designed to investigate TIM-3 expression on tumor infiltrating lymphocytes (TILs), its relationships with clinicopathological para-meters and expression of programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 (PD-L1), and its prognostic role. Methods: Immunohistochemistry on tissue microarray blocks produced from 109 samples of invasive ductal carcinoma type TNBC was performed with antibodies toward TIM-3, PD-1, PD-L1 and breast cancer-related molecular markers. Associations between their expression and clinicopathological parameters as well as survival analyses were performed. Resul...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinical Differences in Triple-Positive Operable Breast Cancer Subtypes in Korean Patients: An Analysis of Korean Breast Cancer Registry Data.
Authors: You SH, Chae BJ, Eom YH, Yoo TK, Kim YS, Kim JS, Park WC Abstract Purpose: Triple-positive breast cancer is defined by estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) positivity. Several systemic breast cancer therapies target hormonal and HER2 responsiveness. We compared clinical outcomes of triple-positive disease with those of HER2-enriched and luminal HER2-negative disease and investigated the clinical efficacy of anti-HER2 therapy for triple-positive disease. Methods: We retrospectively compared overall and recurrence-free survival among cases included...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Neoadjuvant Chemotherapy and Prognosis of Pregnancy-Associated Breast Cancer: A Time-Trends Study of the Korean Breast Cancer Registry Database.
We examined 411 patients with PABC and 83,381 patients with non-PABC. Over time, the proportions of patients undergoing breast-conserving surgery and sentinel lymph node biopsy increased, and neoadjuvant chemotherapy and radiation therapy administration rates also increased. In the past, the overall survival of patients with PABC was poorer than that of patients with non-PABC, but there was no difference in overall survival rates in more recent years. There was no difference in overall survival rates between patients who received neoadjuvant chemotherapy (hazard ratio [HR], 1.28; 95% confidence interval [CI], 0.66-2.49; p=...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Use of Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Patients with Axillary Node-Positive Breast Cancer in Diagnosis.
Conclusion: These results suggest that SLNB can be feasible and oncologically safe after NAC for cytology-determined axillary node metastasis patients and could help reduce arm morbidity and lymphedema by avoiding ALND in SLN-negative patients. PMID: 30607165 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Internal Mammary Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Breast Cancer.
Conclusion: Patients with visualization of IMSLN should perform IM-SLNB after NAC, especially for patients with cN+ disease, in order to complete lymph nodal staging. IM-SLNB could further improve the definition of nodal pCR and guide the internal mammary node irradiation. PMID: 30607166 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Patterns of Axillary Lymph Node Metastasis in Breast Cancer: A Prospective Single-Center Study.
Authors: Choi HJ, Kim JM, Ryu JM, Kim I, Nam SJ, Yu J, Lee SK, Lee JE, Kim SW Abstract Purpose: The recent trend in breast cancer treatment is to minimize axillary dissection. However, no pattern of axillary metastasis has been precisely established. The purpose of this study was to evaluate the metastatic lymphatic pattern using near-infrared fluorescence imaging with indocyanine green (ICG) in breast cancer with cytologically proven axillary metastasis. Methods: This was a prospective single-center study. We evaluated 147 patients with breast cancer involving cytologically proven axillary metastasis, and comp...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Diagnostic Value of Contrast-Enhanced Digital Mammography versus Contrast-Enhanced Magnetic Resonance Imaging for the Preoperative Evaluation of Breast Cancer.
Conclusion: CEDM demonstrated a diagnostic performance comparable with CEMRI in depicting index cancers, secondary cancers, and occult cancer in the contralateral breast. CEDM demonstrated similar changes in surgical management compared with CEMRI. PMID: 30607168 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review.
Authors: Bourcier K, Fermeaux V, Leobon S, Deluche E Abstract Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An 18F-fluoro-deoxy-D-glucose positron emission tomography scan was performed for staging, and low uptakes were observed in the left supraclavicular and cervical lymph nodes. High uptake was seen in the posterior and lower left lobe of the thyroid. Histologic findings indica...
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Open Issues Regarding Cyclin-Dependent Kinase 4/6 Inhibitors in the Management of Advanced Breast Cancer.
Authors: Rossi L PMID: 30607170 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 6, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge.
Authors: Temian DC, Pop LA, Irimie AI, Berindan-Neagoe I Abstract Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remains elusive to targeted therapies-the triple-negative breast cancer. This immunohistochemically defined subtype is resistant to both endocrine and targeted therapies, leading to its poor prognosis. A field that is of great promise in current cancer research...
Source: Journal of Breast Cancer - October 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Patterns of Practice in Radiotherapy for Breast Cancer in Korea.
Authors: Park HJ, Oh DH, Shin KH, Kim JH, Choi DH, Park W, Suh CO, Kim YB, Ahn SD, Kim SS, Division for Breast Cancer, Korean Radiation Oncology Group Abstract Adjuvant radiotherapy (RT) is a well-established treatment for breast cancer. However, there is a large degree of variation and controversy in practice patterns. A nationwide survey on the patterns of practice in breast RT was designed by the Division for Breast Cancer of the Korean Radiation Oncology Group. All board-certified members of the Korean Society for Radiation Oncology were sent a questionnaire comprising 39 questions on six domains: hypofractiona...
Source: Journal of Breast Cancer - October 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Hsa-miRNA-143-3p Reverses Multidrug Resistance of Triple-Negative Breast Cancer by Inhibiting the Expression of Its Target Protein Cytokine-Induced Apoptosis Inhibitor 1 In Vivo.
Conclusion: We partly illustrated the mechanism underlying the hsa-miRNA-143-3p/CIAPIN1 drug resistance pathway. HsamiRNA-143-3p as a tumor suppressive microRNA may be a novel target to effectively reverse MDR of TNBC in vivo. PMID: 30275853 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Hypoxia-Inducible Factor 1 α Regulates the Transforming Growth Factor β1/SMAD Family Member 3 Pathway to Promote Breast Cancer Progression.
Conclusion: HIF-1α serves as an upstream regulator of the TGF-β1/SMAD3 pathway and promotes the growth of breast cancer. PMID: 30275854 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 4, 2018 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research