Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy.
Authors: Faria SS, Corrêa LH, Heyn GS, de Sant'Ana LP, Almeida RDN, Magalhães KG Abstract Obesity is associated with increased risk and aggressiveness of many types of cancer. Women with obesity and breast cancer are more likely to be diagnosed with larger and higher-grade tumors and have higher incidence of metastases than lean individuals. Increasing evidence indicates that obesity includes systemic, chronic low-grade inflammation, and that adipose tissue can act as an important endocrine site, secreting a variety of substances that may regulate inflammation, immune response, and cancer predispositio...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Assessment of the Predictive Role of Serum Lipid Profiles in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.
This study aimed to investigate the predictive value of serum lipid profiles for the response to NAC in breast cancer patients. Methods: A total of 533 breast cancer patients who had received NAC were retrospectively studied. The pretreatment of serum lipids, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipoprotein-α, and clinicopathological characteristics were collected to assess their predictive roles. Results: Breast cancer patients had significantly lower TC, TG, HDL-C, and LDL-C levels than normal ind...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Relative Survival Benefit by Hormonal Receptor Status of Adding Trastuzumab to Neoadjuvant Chemotherapy in Breast Cancer Patients.
Conclusion: We found that the addition of trastuzumab to NAC improved relative survival benefit in HER2+/HR+ patients than in HER2+/HR- patients, even though the pCR rate increases were lower. Although pCR has been regarded as a surrogate marker for estimating long-term survival benefits after NAC, it alone may not translate into real long-term oncologic outcomes in particular cancer subtypes after trastuzumab-based NAC. Further longer-term evaluation of the objective survival benefit after NAC driven by a dual HER2 block according to HR status is warranted. PMID: 32595988 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Effect of Timing of Gonadotropin-Releasing Hormone Agonist Administration for Ovarian Protection in Patients with Breast Cancer.
Conclusion: There was no difference in the ovarian protective effect according to the difference in the timing of administration of GnRHa. PMID: 32595989 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Identifying Long-Term Survival Candidates among Patients with Isolated Locoregionally Recurrent Breast Cancer: Implications of the Use of Systemic Chemotherapy.
Authors: Kim BH, Shin KH, Chie EK, Kim JH, Kim K, Hwang KT, Kim J, Choi IS, Park JH, Kim S Abstract Purpose: We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods: We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results: Fifty-two (41.6%) patients experienced secondary recurrence or disea...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Coronary Event Analysis in Breast Cancer Patients Who Received Breast-Conserving Surgery and Post-Operative Radiotherapy: a Korean Nationwide Cohort Study.
Authors: Sung SY, Lee JH, Yang KH, Seo Y, Kang MY Abstract Purpose: Adjuvant breast radiotherapy (RT) following breast-conserving surgery (BCS) has been reported to induce cardiac toxicity in breast cancer patients. We investigated the incidence and risk factors of major coronary events after breast RT using Korean nationwide Health Insurance Review and Assessment data. Methods: Using data from a nationwide quality assessment of breast cancer treatment, we identified 3,251 patients who received breast RT after BCS in 2013. Data about major coronary events were additionally collected from national claims data. W...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Concordance of Programmed Death-Ligand 1 Expression between SP142 and 22C3/SP263 Assays in Triple-Negative Breast Cancer.
Conclusion: This study demonstrates that although the 22C3 assay at a 1% cut-off value compared with the PD-L1 SP142 assay at the clinically relevant cut-off shows comparable but not interchangeable analytical performance, the analytical performance of the SP263 assay at a 1% cut-off value shows interchangeable performance with the PD-L1 SP142 assay at the clinically relevant cut-off. PMID: 32595992 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06).
Authors: Kim K, Jung J, Shin KH, Kim JH, Chang JH, Kim SS, Kim H, Park W, Kim YB, Chang JS Abstract The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. All patients underwent breast-conserving surgery followed by whole-breast irradiation; only 2 patients received regional nodal irradiation (RNI). The RS was 25 in 43. Sixty-two patients received adj...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Cutaneous Scalp Metastases of Malignant Phyllodes Tumor of the Breast.
Authors: Lee HJ, Lim HS, Ki SY, Lee JE, Lee JS, Park MH Abstract Phyllodes tumor (PT) of the breast is a relatively rare fibroepithelial tumor that accounts for
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Anastomosing Hemangioma of the Breast: An Unusual Case at an Unusual Site.
We report a case of AH in a 49-year-old woman presenting as a mass in the breast, a site which, to the best of our knowledge, has not been previously documented in the English literature. Microscopic examination of the mass revealed a well-demarcated proliferation of anastomosing vascular spaces lined by bland endothelial cells, with focal hobnailing and scattered intravascular fibrin thrombi. No mitotic activity was observed and the Ki-67 proliferative index was low. These features were interpreted as AH, a lesion that may be difficult to distinguish from low-grade angiosarcoma or other benign vascular lesions of the brea...
Source: Journal of Breast Cancer - July 2, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Breast Cancer Statistics in Korea in 2017: Data from a Breast Cancer Registry.
This article describes the breast cancer statistics in Korea, including the incidence, type of surgical procedure, stage, and molecular subtype, using the Korean Breast Cancer Society (KBCS) and Korea Central Cancer Registry data. There were a total of 26,534 new breast cancer diagnoses in 2017 in Korea, of which 4,139 were carcinoma in situ cases and 22,395 were invasive cancer cases. The age standardized rate of breast cancer was 75.3 per 100,000 women in 2017 (63.0 of invasive carcinoma and 12.3 of carcinoma in situ), and it has been steadily increasing across all age groups. Breast cancer occurred most commonly in the ...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Role of Long Noncoding RNAs in Antiestrogen Resistance in Breast Cancer: An Overview and Update.
Authors: Huang L, Liang G, Zhang Q, Zhao W Abstract As a standard treatment, endocrine therapy has dramatically enhanced the prognosis of patients with estrogen receptor (ER)-positive breast cancer, which accounts for nearly 70% of all breast cancers. Antiestrogen drugs such as tamoxifen and aromatase inhibitors are the standard treatment options for ERα-positive breast cancer. However, acquired antiestrogen resistance is still the leading cause of disease recurrence and progression. Evidence has shown that long noncoding RNAs (lncRNAs) play an essential role in the development of antiestrogen resistance in E...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Myeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling.
Conclusion: CCL3 promoted the growth of breast cancer cells, and MDSCs recruited by CCL3 interacted with these cells and then activated the PI3K-Akt-mTOR pathway, which led to EMT and promoted the migration and invasion of the cells. PMID: 32395374 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers.
Conclusion: CDK2 kinase activity was significantly upregulated in basal breast cancer tumors and was negatively correlated with p27 protein levels in the TCGA breast cancer dataset, suggesting that targeting CDK2 may be an effective treatment strategy for TNBC patients. PMID: 32395375 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinical Significance of C-X-C Motif Chemokine Receptor 4 and Integrin αvβ6 Expression in Breast Cancer.
In this study, we investigated the expression of CXCR4 and integrin αvβ6 in BC tissues and their correlation with clinicopathological characteristics, including survival. Methods: CXCR4 and αvβ6 expression in 111 BC tissues was examined by immunocytochemistry. Correlations between the expression of the 2 proteins and patient clinicopathological characteristic were investigated using the Kaplan-Meier method and the Cox proportional hazards model. Results: CXCR4 and αvβ6 were overexpressed in BC tissue compared with normal breast tissue. Overexpression of both molecules was related to...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Role of Androgen Receptor Expression in Surgically Resected Early Breast Cancer Patients.
Conclusion: We propose a cut-off value of 35% to best predict RFS in patients with surgically resected breast cancer. AR expression was positive in 68.4% of patients, and AR positivity was found to be an independent prognostic factor for longer RFS. PMID: 32395377 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Cervical Lymph Node Involvement above the Supraclavicular Fossa in Breast Cancer: Comparison with Stage IIIC (KROG 18-02).
Conclusion: The comparable clinical outcomes indicate that patients with breast cancer who have ipsilateral CLN metastasis without other distant metastasis may benefit from locoregional treatment of the ipsilateral breast and systemic therapies, as do those with N3c disease. PMID: 32395378 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Pro-inflammatory Cytokine Levels and Cancer-related Fatigue in Breast Cancer Survivors: Effects of an Exercise Adherence Program.
Conclusion: The BLESS intervention improved CRF in BCS immediately at post-intervention, and this study presents clinical feasibility for the management of CRF in BCS in the early survivorship phase who are already experiencing fatigue. PMID: 32395379 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

ESR1 Mutation Detection and Dynamics in Meningeal Carcinomatosis in Breast Cancer.
Authors: Carausu M, Melaabi S, Pierga JY, Bidard FC, Cabel L Abstract ESR1 mutation is frequently encountered in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC), especially after aromatase inhibitor (AI) therapy, as a mechanism of resistance to endocrine therapy. Circulating tumor DNA-based detection of ESR1 mutation in plasma has been demonstrated as a prognostic and predictive factor for poor outcomes in subsequent AI therapy. In this case report, for the first time, we describe the detection of ESR1 mutation (p.Tyr537Ser) only in the cerebro...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Recurrence of Breast Carcinoma as Paget's Disease of the Skin along the Core Needle Biopsy Tract after Skin-Sparing Mastectomy.
We report a case of recurrence as Paget's disease at the core needle biopsy (CNB) entry site in a patient with microinvasive ductal carcinoma who underwent nipple-areola-skin sparing mastectomy (NASSM) and autologous reconstruction. Clinically diagnosed recurrences associated with previous needle procedures for malignant breast lesions are rare and usually occur in patients who have not received radiation therapy. The present case involved local recurrence at the skin puncture site of a patient diagnosed based on CNB findings who underwent NASSM without receiving radiation therapy. Although the removal of the CNB tract wit...
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer.
Authors: Lei C, Yang C, Xia B, Ji F, Zhang Y, Gao H, Xiong Q, Lin Y, Zhuang X, Zhang L, Zhu T, Cheng M, Yang M, Wang K Abstract [This corrects the article on p. 47 in vol. 23, PMID: 32140269.]. PMID: 32395382 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: c-Myc-Induced Long Non-Coding RNA Small Nucleolar RNA Host Gene 7 Regulates Glycolysis in Breast Cancer.
Authors: Zhang L, Fu Y, Guo H Abstract [This corrects the article on p. 533 in vol. 22, PMID: 31897328.]. PMID: 32395383 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - May 14, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Matrix Metallopeptidase 3 Polymorphisms: Emerging genetic Markers in Human Breast Cancer Metastasis.
Authors: Suhaimi SA, Chan SC, Rosli R Abstract Matrix metallopeptidase 3 or MMP3, is a zinc-dependent proteolytic enzyme that is involved in various physiological processes via modification of the extracellular matrix. In particular, its over-expression has been associated with cancer metastasis and tumor growth in various cancers including breast cancer. MMP3 gene expression is regulated by several factors such as DNA polymorphisms which also serve as risk factors for breast cancer. As such, DNA polymorphisms of MMP3 have the potential to be utilized as genetic biomarkers for prediction and prognosis of metastatic...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Predicting the Benefit of Adjuvant Aromatase Inhibitor Therapy in Postmenopausal Breast Cancer Patients with Phosphorylated S6K1 Expression Status.
This study aimed to investigate the potential of pS6K1 as a predictive marker of adjuvant aromatase inhibitor (AI) therapy outcome in postmenopausal or ovarian function-suppressed patients with hormone-sensitive breast cancer. Methods: Medical records were retrospectively reviewed in postmenopausal or ovarian function-suppressed patients with estrogen receptor-positive and node-positive primary breast cancer. pS6K1 expression status was scored on a scale from 0 (negative) to 3+ (positive) based on immunohistochemical analysis. Results: A total of 428 patients were eligible. The median follow-up duration was 44 mont...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1.
Conclusion: Our findings demonstrated that PA directly bound to CtBP1 and inhibited the growth and migration of breast cancer cells through CtBP1 inhibition. Structural modifications of PA are further required to enhance its binding affinity and selectivity for CtBP1. PMID: 32140267 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Downregulation of N-myc and STAT Interactor Protein Predicts Aggressive Tumor Behavior and Poor Prognosis in Invasive Ductal Carcinoma.
Authors: Choi JE, Hyun CL, Jin MS, Lee KM, Moon JH, Ryu HS Abstract Purpose: We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. The expression levels and prognostic significance of NMI were also analyzed according to the molecular subgroup of breast cancers. Methods: Human NMI detection by immunohistochemistry was performed using tissue microarrays of 382 invasive ductal carcinomas. The correlation of NMI expression with patient clinicopathological parameters and prognostic sig...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer.
Conclusion: Tau protein expression can predict pCR before NACT in TNBC, but there was no correlation between Tau expression and DFS or OS. PMID: 32140269 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Assessment of the Prognostic Staging System of American Joint Committee on Cancer 8th Edition for Breast Cancer: Comparisons with the Conventional Anatomic Staging System.
This study aimed to evaluate the changes in staging distribution and predictive power of the new staging system. Methods: Of the 12,275 patients with breast cancer identified from the Severance Breast Cancer Registry who underwent surgery between 1978 and 2016, 12,125 patients met the inclusion criteria. Results: In both the 7th and 8th staging systems, stage I patients constituted the largest proportion (38.2% and 48.4%). Migration from the 7th to 8th edition of the AJCC manual resulted in a decrease in stage II population and an increase in stage I and III populations. A total of 1,293 (15.4%) patients were upsta...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma.
Authors: Zouine S, Marnissi F, Otmani N, Bennani Othmani M, Zaid N, Kojok K, Zaid Y, Tahiri Jouti N, Habti N Abstract Purpose: Aberrant glycosylation of the histo-blood group antigens (including the angina bullosa haemorrhagica [ABH]) is often observed during malignant transformation in most types of carcinomas. Data concerning their ethnic distributions are diverse which explains why their biological characteristics have to be studied in different populations. Our aim was to analyze the expression of the histo-blood group (specifically the ABH) antigens in breast carcinoma. Methods: The expression of the histo...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Value of Skeletal Muscle Depletion Measured on Computed Tomography for Overall Survival in Patients with Non-Metastatic Breast Cancer.
Conclusion: Skeletal muscle depletion measured on CT was associated with worse OS outcome in patients with non-metastatic breast cancer. PMID: 32140272 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity.
Authors: Febres-Aldana CA, Mejia-Mejia O, Krishnamurthy K, Mesko T, Poppiti R Abstract Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells around small epithelial-lined spaces. Due to the rarity of adenomyoepitheliomas, the molecular data describing them are limited. Adenomyoepitheliomas are considered to be benign or have low malignant potential, and be prone to local recurrence. Malignant transformation has been associated with homozygous deletion of CDKN2A or somatic mutations in TERT, but remains unexplained in many cases. Here, we describe a case of carcinomatous transfo...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Acute Lymphoblastic Leukemia in a Patient Treated with Letrozole and Palbociclib.
Authors: Park JH, Park H, Kim KH, Kim JS, Choi IS, Roh EY, Kim JE, Chang MS Abstract Palbociclib, in conjunction with endocrine therapy, has been approved for the treatment of patients with advanced breast cancer. The common hematological toxicities associated with palbociclib are leukopenia and neutropenia. However, hematological malignancies have not been reported for palbociclib treatment. Here, for the first time, we present a case of acute lymphoblastic leukemia that was diagnosed in a patient undergoing treatment with letrozole and palbociclib for metastatic breast cancer. This case emphasizes the need for lo...
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Development of Robotic Mastectomy Using a Single-Port Surgical Robot System.
We report the development of a robotic nipple-sparing mastectomy with immediate reconstruction through a single incision using the updated single-port surgical robot system for a patient with ductal carcinoma in situ (DCIS). Breast reconstruction was performed using implants. Postoperative pathological examination revealed DCIS in both breasts. There were no major immediate complications, except for a minor skin burn on the right breast. Overall, the initial operation using the updated platform was safely performed. PMID: 32140275 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: A Validation Study of a Multiple Reaction Monitoring-Based Proteomic Assay to Diagnose Breast Cancer.
Authors: Kim Y, Kang UB, Kim S, Lee HB, Moon HG, Han W, Noh DY Abstract [This corrects the article on p. 579 in vol. 22, PMID: 31897331.]. PMID: 32140276 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 8, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Predictive and Prognostic Roles of Pathological Indicators for Patients with Breast Cancer on Neoadjuvant Chemotherapy.
Authors: Li X, Wang M, Wang M, Yu X, Guo J, Sun T, Yao L, Zhang Q, Xu Y Abstract Currently, neoadjuvant chemotherapy is a standard therapeutic strategy for breast cancer, as it can provide timely and individualized chemo-sensitivity information and is beneficial for custom-designing subsequent treatment strategies. To accurately select candidates for neoadjuvant chemotherapy, the association between various immunohistochemical biomarkers of primary disease and tumor response to neoadjuvant chemotherapy has been investigated, and results have shown that certain pathological indicators evaluated after neoadjuvant che...
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/ β-Catenin Pathway.
Conclusion: Endogenous KIF11 enhances the self-renewal of breast cancer cells by activating the Wnt/β-catenin signaling pathway, thereby enhancing the characteristics of breast cancer stem cells. PMID: 31897327 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

c-Myc-Induced Long Non-Coding RNA Small Nucleolar RNA Host Gene 7 Regulates Glycolysis in Breast Cancer.
Conclusion: We demonstrated that c-Myc regulated glycolysis through the lncRNA-SNHG7/miR-34a-5p/LDHA axis in breast cancer cells. PMID: 31897328 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Role of KRAS mRNA Expression in Breast Cancer.
Authors: Hwang KT, Kim BH, Oh S, Park SY, Jung J, Kim J, Choi IS, Jeon SY, Kim WY Abstract Purpose: We investigated the prognostic role of KRAS mRNA expression in breast cancer using The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) databases. Methods: Clinical and biological data of 1,093 breast cancers from TCGA database and 1,904 breast cancers from METABRIC database were analyzed. Overall survival (OS) and breast cancer-specific survival (BCSS) were determined. Results: The group with high KRAS mRNA expression showed worse survival than the group ...
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Notch1 in Tumor Microvascular Endothelial Cells and Tumoral miR-34a as Prognostic Markers in Locally Advanced Triple-Negative Breast Cancer.
Conclusion: The fact that miR-34a and EC Notch1 are associated with the angiogenesis suggests that angiogenesis may play a role in the development and progression of TNBC. PMID: 31897330 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

A Validation Study of a Multiple Reaction Monitoring-Based Proteomic Assay to Diagnose Breast Cancer.
Conclusion: The data demonstrated that an MRM-based proteomic assay that measures plasma levels of three specific peptides can be a useful tool for breast cancer screening and its accuracy is cancer-type specific. PMID: 31897331 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Contralateral Breast Cancer and Ipsilateral Breast Tumor Recurrence in BRCA1/2 Carriers and Non-Carriers at High-Risk of Hereditary Breast Cancer.
Conclusion: While BRCA1/2 mutation carriers had a higher risk of developing CBC compared to non-carriers at high-risk of HBOC, the risk of IBTR was similarly high across breast cancer patients irrespective of the BRCA mutation. Further preventive strategies to reduce CBC and IBTR for all patients at high-risk of HBOC should be investigated. PMID: 31897332 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Omission of Chemotherapy for the Treatment of Mucinous Breast Cancer: A Nationwide Study from the Korean Breast Cancer Society.
Conclusion: Our large retrospective analysis revealed that adjuvant chemotherapy provided little benefit to improve the prognosis of most ER-positive MBC patients. Therefore, chemotherapy can be omitted in the treatment of most ER-positive MBC. PMID: 31897333 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Oncologic Outcomes of Nipple-Sparing Mastectomy with Immediate Breast Reconstruction in Patients with Tumor-Nipple Distance Less than 2.0 cm.
Authors: Alsharif E, Ryu JM, Choi HJ, Nam SJ, Kim SW, Yu J, Chae BJ, Lee SK, Lee JE Abstract Purpose: Although the indications for nipple-sparing mastectomy (NSM) are expanding, there remains a debate regarding the oncologic outcomes of patients treated with this method, especially those with a short tumor-nipple distance (STND). The aim of this study was to compare the long-term oncologic outcomes between patients with a long tumor-nipple distance (LTND) (≥ 2.0 cm) and those with STND (
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Amenorrhea and Menopause in Patients with Breast Cancer after Chemotherapy.
This study aimed to assess the rate of ovarian failure in a large cohort of Korean premenopausal patients with breast cancer 12 months after chemotherapy. Methods: This retrospective cohort study included premenopausal women (aged 20-44 years) with breast cancer who underwent chemotherapy after surgery. The rates of treatment-related amenorrhea (TRA) and chemotherapy-induced menopause (CIM) at 12 months after chemotherapy were analyzed. Results: A total of 237 patients met the inclusion criteria. The rate of TRA was 61.6% and that of CIM was 13.1% at 12 months after chemotherapy. The rates of TRA and CIM were 28.0%...
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Intraoperative Specimen Mammography for Margin Assessment in Breast-Conserving Surgery.
Authors: Jin M, Kim JY, Kim TH, Kang DK, Han SH, Jung Y Abstract The purpose of this study aimed to determine whether intraoperative specimen mammography is an effective margin assessment method in Asian women. Thus, 182 patients who underwent breast-conserving surgery (BCS) were evaluated. After wide excision, intraoperative specimen mammography was used to assess margin adequacy. The control group comprised 84 patients who underwent BCS and were evaluated for margin of frozen section during surgery. 61.6% patients had dense breasts and 85.7% of dense breasts could margin assess by intraoperative specimen mammogra...
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Skin-sparing Mastectomy and Immediate Nipple Graft for Large, Ptotic Breast.
Authors: Kim EK, Cho JM, Lee JW Abstract Nipple-areolar skin-sparing mastectomy followed by autologous reconstruction in patients with large, ptotic breasts often offers a limited field, resulting in strenuous traction. Skin-sparing mastectomy (SSM) with immediate nipple grafting from the specimen was attempted for such patients. Patients who underwent SSM with immediate autologous breast reconstruction and nipple grafting between September 2016 and February 2019 were evaluated, including 33 nipple grafts in 30 patients. The average weight of the mastectomy specimen was 552.5 g and the average operation time for un...
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinical Effects of Hypomethylating Agents in Patients with Newly Diagnosed Myelodysplastic Syndrome Who Received DNA-Damaging Chemotherapy for Metastatic Breast Cancer.
This report reviews the use of hypomethylating agents (HMAs) to treat a 57-year-old woman newly diagnosed with MDS during palliative chemotherapy for metastatic breast cancer. Over a period of 6 years, the patient received several DNA-damaging chemotherapeutics including doxorubicin, cyclophosphamide, and paclitaxel. Repeated thrombocytopenia was the main reason for suspecting secondary hematologic malignancy. She was diagnosed with t-MDS based on bone marrow examination and her treatment history for breast cancer. While azacitidine was originally administered to stabilize MDS, it also stabilized the patient's lung and lym...
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Salivary Duct Cancer Metastasis Mimicking Primary Breast Cancer: A Case Report and Review.
This report presents the case of a woman who was initially diagnosed with and treated for parotid carcinoma. Two years later, during a follow-up visit, a breast lump was discovered, which was diagnosed as primary breast cancer and managed surgically. After surgery, hematoxylin and eosin and immunohistochemical staining revealed that the breast tumor had the same features as her primary SDC. Here, we present a confusing case of SDC metastasis to the breast that mimicked triple-negative breast cancer. PMID: 31897339 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Ribociclib-Related Stevens-Johnson Syndrome: Oncologic Awareness, Case Report, and Literature Review.
Authors: López-Gómez V, Yarza R, Muñoz-González H, Revilla E, Enrech S, González-Valle O, Tolosa P, Ciruelos E Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering, and further skin detachment. Notably, cancer patients are at higher risk of developing SJS than the general population as a consequence of both the nature of neoplastic disease and frequent exposure to antican...
Source: Journal of Breast Cancer - January 5, 2020 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Druggable Molecular Targets for the Treatment of Triple Negative Breast Cancer.
Authors: Nakhjavani M, Hardingham JE, Palethorpe HM, Price TJ, Townsend AR Abstract Breast cancer (BC) is still the most common cancer among women worldwide. Amongst the subtypes of BC, triple negative breast cancer (TNBC) is characterized by deficient expression of estrogen, progesterone, and human epidermal growth factor receptor 2 receptors. These patients are therefore not given the option of targeted therapy and have worse prognosis as a result. Consequently, much research has been devoted to identifying specific molecular targets that can be utilized for targeted cancer therapy, thereby limiting the progressi...
Source: Journal of Breast Cancer - October 12, 2019 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research