Biomarkers of Everolimus Sensitivity in Hormone Receptor-Positive Breast Cancer.
Authors: Yi Z, Ma F Abstract Activation of the mammalian target of rapamycin (mTOR) signaling pathway is an important mechanism of resistance to endocrine therapy in breast cancer. Everolimus, an mTOR inhibitor, has been shown to increase the efficacy of endocrine therapy and overcome resistance to endocrine therapies. Clinical studies have suggested that everolimus combined with endocrine therapy prolongs progression-free survival in hormone receptor-positive breast cancer patients. However, because breast cancer includes a group of highly heterogeneous tumors, patients may have different responses to everolimus. ...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Selective Radiation Therapy for Ductal Carcinoma In Situ Following Breast-Conserving Surgery According to Age and Margin Width: Korean Radiation Oncology Group 11-04 and 16-02 Studies.
Authors: Kim K, Kim JH, Kim YB, Suh CO, Shin KH, Kim JH, Kim TH, Jung SY, Choi DH, Park W, Ahn SD, Kim SS, Yea JW, Kang MK, Kim DW, Kim YJ Abstract Purpose: The optimal indications for omitting adjuvant radiation therapy (RT) after breast-conserving surgery are still controversial in ductal carcinoma in situ (DCIS) of the breast. The purpose of this study was to validate the role of postoperative RT in DCIS patients aged ≤50 years and with tumor margin widths of
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Interactions of Family History of Breast Cancer with Radiotherapy in Relation to the Risk of Breast Cancer Recurrence.
Conclusion: Radiotherapy for a primary breast cancer in women with a family history of breast cancer does not increase risk of breast cancer recurrence. If these findings are replicated in future studies, the results may translate into an important health message for breast cancer survivors with a family history of breast cancer. PMID: 29285037 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

A Multicenter Phase II Trial of Neoadjuvant Chemotherapy with Docetaxel and Gemcitabine in Locally Advanced Breast Cancer.
Conclusion: The combination of docetaxel and gemcitabine did not improve pCR. However, this regimen has shown potential as a NAC by producing a reasonable rate of breast-conserving surgery and favorable responses in patients with locally advanced breast cancer. The therapeutic efficacy of this regimen will be determined in additional trials to overcome the limitations of the current study. PMID: 29285038 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Cyclophosphamide, Methotrexate, and 5-Fluorouracil as Palliative Treatment for Heavily Pretreated Patients with Metastatic Breast Cancer: A Multicenter Retrospective Analysis.
Conclusion: CMF therapy is effective and tolerable as salvage treatment for heavily pretreated MBC. PMID: 29285039 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Tamoxifen and the Risk of Parkinson's Disease in Female Patients with Breast Cancer in Asian People: A Nationwide Population-Based Study.
Conclusion: Tamoxifen treatment may increase the risk of PD in Taiwanese female patients with breast cancer more than 6 years after the initiation of treatment. PMID: 29285040 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Wnt7a Deficiency Could Predict Worse Disease-Free and Overall Survival in Estrogen Receptor-Positive Breast Cancer.
This study aimed to detect the level of Wnt7a expression in breast cancer and explore its role in the disease progression and prognosis. Methods: A total of 258 patients diagnosed with invasive ductal carcinoma of the breast were included in this study. Using tissue microarray and immunohistochemical staining, we evaluated the association between Wnt7a expression and clinicopathological parameters, and the prognostic value of Wnt7a. Results: Wnt7a expression was significantly correlated with estrogen receptor (ER) expression (odds ratio, 3.95; 95% confidence interval [CI], 1.99-7.80; p
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Treatment Patterns and Outcomes in Elderly Patients with Metastatic Breast Cancer: A Multicenter Retrospective Study.
Conclusion: Elderly patients with MBC should not be excluded from receiving standard treatments prescribed for younger patients. Future research plans for elderly patients, especially aged ≥75 years with breast cancer, should include a geriatric assessment for identifying individuals at risk for treatment-related toxicity. Overall, this analysis will provide a better understanding of this population and help guide clinical care in real-world practice. PMID: 29285042 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Improved Model for Predicting Axillary Response to Neoadjuvant Chemotherapy in Patients with Clinically Node-Positive Breast Cancer.
Conclusion: Tumor response rate was the most significant independent predictor of axillary pCR in response to NAC. The model that included tumor response rate was a significantly better predictor of axillary pCR than the model that excluded tumor response rate. PMID: 29285043 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Metabolic Activity of Normal Glandular Tissue on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography: Correlation with Menstrual Cycles and Parenchymal Enhancements.
Authors: An YS, Jung Y, Kim JY, Han S, Kang DK, Park SY, Kim TH Abstract Purpose: The aims of our study were to correlate the degree of metabolic activity in normal glandular tissue measured on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) with qualitative background parenchymal enhancement (BPE) grades on magnetic resonance imaging (MRI), and to investigate the change in standardized uptake value (SUV) according to the patients' menstrual cycles. Methods: From January 2013 to December 2015, 298 consecutive premenopausal patients with breast cancer who underwent both b...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Optimization of RNA Extraction from Formalin-Fixed Paraffin-Embedded Blocks for Targeted Next-Generation Sequencing.
Conclusion: Archived FFPE tissues can be used to extract RNA for NGS if they are properly processed before fixation. The expected amount of RNA per unit size calculated in this study will be useful for other researchers. PMID: 29285045 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Practice Patterns and Perceptions of Korean Surgeons Regarding Margin Status after Breast-Conserving Surgery.
Authors: Yoo TK, Kim SW, Kang E, Ahn SG, Hwang KT, Kim SK, Woo SU, Shin HJ, Song YJ, Jung EJ, Chang MC, Lee I, Park WC, Korean Breast Cancer Society Abstract Two consecutive surveys for breast surgeons in Korea were conducted to comprehend the practice patterns and perceptions on margin status after breast-conserving surgery. The surveys were conducted online in 2014 (initial) and 2016 (follow-up). A total of 126 and 88 responses were obtained in the initial and follow-up survey, respectively. More than 80% of the respondents replied to routinely apply frozen section biopsy for intraoperative margin assessment in b...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Ectopic Male Breast Cancer in the Perineum: A Case Report.
Authors: Eom HJ, Ko BS, Song IH, Gong G, Kim HH Abstract Ectopic breast tissue and male breast cancer are both very rare diseases with only a few reports in the literature. Here, we present the first case of ectopic male breast cancer in the perineum. The patient was a 70-year-old man with a palpable mass in the perineum. A wide local excision and inguinal lymph node dissection revealed invasive breast carcinoma of no special type involving the skin and subcutis, and inguinal lymph node metastases. Immunohistochemical staining showed that the tumor cells were strongly positive for estrogen and progesterone receptor...
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Follow-up Outcomes of Benign Pathology Initially Assigned as Breast Imaging Reporting and Data System Category 4A and 3.
Authors: You JY, Suh HJ, Kim Y, Jun JK, Ojeda-Fournier H, Ko K Abstract [This corrects the article on p. 304 in vol. 20, PMID: 28970857.]. PMID: 29285048 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - December 31, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Sentinel Lymph Node Biopsy in Breast Cancer: A Clinical Review and Update.
This article discusses how sentinel lymph node biopsy has evolved and is becoming a useful tool in new clinical scenarios of breast cancer management. PMID: 28970846 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Meeting Highlights: The Second Consensus Conference for Breast Cancer Treatment in Korea.
Discussions on radiotherapy addressed the need for adjuvant radiotherapy and radiation field of regional lymph node in the context of various N1 breast cancer cases. The participants reached a consensus to recommend that N1 patients should receive regional nodal irradiation for a large tumor burden (e.g., three positive nodes, perinodal extension, or large primary tumor). Finally, the panels favored OFS in addition to endocrine therapy for premenopausal women with high risk factors such as a large tumor size, involvement of more than three nodes, and a high histologic grade. PMID: 28970847 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells.
CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C δ/p38/c-Jun N-terminal kinase/AP-1 pathway. Therefore, CFE could restrict breast cancer invasiveness owing to its ability to inhibit MMP-9 activity. PMID: 28970848 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Gene Regulatory Network Analysis for Triple-Negative Breast Neoplasms by Using Gene Expression Data.
CONCLUSION: Our TNBN gene regulatory network was a scale-free one, which means that the network would be easily destroyed if the hub vertices were attacked. Thus, it is important to identify the hub vertices in the network analysis. In the TNBN gene regulatory network, ZDHHC20 and RAPGEF6 were found to be oncogenes. Further study of these genes could help to reveal a novel method for treating TNBN in the future. PMID: 28970849 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Copy Number Profiling of MammaPrint ™ Genes Reveals Association with the Prognosis of Breast Cancer Patients.
CONCLUSION: Based on these findings, a concordance of CNV-based genomic rearrangement with expression profiling of these genes and their putative roles in disease tumorigenesis was established. The results suggested that the CNV profiles of the MammaPrint™ genes can be used to predict the prognosis of breast cancer patients. In addition, this approach may lead to the development of new cancer biomarkers at the DNA level. PMID: 28970850 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer.
Authors: Hwang KT, Chung JK, Roh EY, Kim J, Oh S, Kim YA, Rhu J, Kim S Abstract PURPOSE: Elevated serum concentration of fibrinogen and decreased serum concentration of albumin have been reported to be markers of elevated systemic inflammation. We attempted to investigate the prognostic influence of preoperative fibrinogen to albumin ratio (FAR) for breast cancer. METHODS: Data from 793 consecutive primary breast cancer patients were retrospectively analyzed. Serum levels of fibrinogen and albumin were tested before curative surgery. Subjects were grouped into two groups according to the cutoff value determined...
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinicopathologic Characteristics of Pregnancy-Associated Breast Cancer: Results of Analysis of a Nationwide Breast Cancer Registry Database.
This study aimed to evaluate the clinicopathological characteristics of pregnancy-associated breast cancer (PABC) in comparison with non-pregnancy associated breast cancer (non-PABC). METHODS: A total of 344 eligible patients with PABC were identified in the Korean Breast Cancer Society Registry database. PABC was defined as ductal carcinoma in situ, invasive ductal carcinoma, or invasive lobular carcinoma diagnosed during pregnancy or within 1 year after the birth of a child. Patients with non-PABC were selected from the same database using a 1:2 matching method. The matching variables were operation, age, and initial...
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Development of a Nomogram to Predict N2 or N3 Stage in T1-2 Invasive Breast Cancer Patients with No Palpable Lymphadenopathy.
Authors: Kim I, Ryu JM, Kim JM, Choi HJ, Lee SK, Yu JH, Lee JE, Kim SW, Nam SJ Abstract PURPOSE: Subsequent to the American College of Surgeons Oncology Group (ACOSOG) Z0011 and After Mapping of the Axilla: Radiotherapy or Surgery (AMAROS) trials, complete axillary lymph node dissection is not routinely performed, even in cases where metastatic sentinel lymph nodes are detected. We investigated the percentage of N2 or N3 stages in T1-2 invasive breast cancer patients with no lymphadenopathy and developed a nomogram to predict the possibility of N2 or N3 stages in these patients. METHODS: We retrospectively revi...
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Effect of Reproductive Factors on Breast Cancer Presentation in Women Who Are BRCA Mutation Carrier.
Authors: Kim JY, Moon HG, Kang YJ, Han W, Noh WC, Jung Y, Moon BI, Kang E, Park SS, Lee MH, Park BY, Lee JW, Noh DY Abstract PURPOSE: Germline mutations in the BRCA1 and BRCA2 genes confer increased risks for breast cancers. However, the clinical presentation of breast cancer among women who are carriers of the BRCA1 or BRCA2 (BRCA1/2 carriers) mutations is heterogenous. We aimed to identify the effects of the reproductive histories of women with the BRCA1/2 mutations on the clinical presentation of breast cancer. METHODS: We retrospectively analyzed clinical data on women with proven BRCA1 and BRCA2 mutations ...
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

NanoString nCounter ® Approach in Breast Cancer: A Comparative Analysis with Quantitative Real-Time Polymerase Chain Reaction, In Situ Hybridization, and Immunohistochemistry.
NanoString nCounter® Approach in Breast Cancer: A Comparative Analysis with Quantitative Real-Time Polymerase Chain Reaction, In Situ Hybridization, and Immunohistochemistry. J Breast Cancer. 2017 Sep;20(3):286-296 Authors: Hyeon J, Cho SY, Hong ME, Kang SY, Do I, Im YH, Cho EY Abstract PURPOSE: Accurate testing for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is essential for breast cancer treatment. At present, immunohistochemistry (IHC)/florescence in situ hybridization (FISH) are widely accepted as the standard testing methods. To inves...
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Comparison of Core Needle Biopsy and Surgical Specimens in Determining Intrinsic Biological Subtypes of Breast Cancer with Immunohistochemistry.
CONCLUSION: CNB showed high diagnostic accuracy compared with surgical specimens, and good agreement for ER, PR, HER2, and Ki-67. Our findings reaffirmed the recommendation of CNB as an initial procedure for breast cancer diagnosis, and the assessment of receptor status and intrinsic biological subtypes to determine further treatment plans. PMID: 28970856 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Follow-up Outcomes of Benign Pathology Initially Assigned as Breast Imaging Reporting and Data System Category 4A and 3.
CONCLUSION: The initial category 4A or 3 of the Breast Imaging Reporting and Data System could be a significant factor that affects immediate surgical excision and follow-up compliance. Cancers were detected only in the initial category 4A group of concordant benign lesions. More attention should be paid to the concordant benign lesions from the initial category 4A group than from the category 3 group. PMID: 28970857 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

A Novel Germline Mutation in BRCA1 Causes Exon 20 Skipping in a Korean Family with a History of Breast Cancer.
This report describes a family with a history of breast and ovarian cancers that harbored a novel BRCA1 germline mutation. A single nucleotide deletion in intron 20, namely c.5332+4delA, was detected in a 43-year-old patient with breast cancer. This mutation led to the skipping of exon 20, which in turn resulted in the production of a truncated BRCA1 protein that was 1773 amino acids in length. The mother of the proband had died due to ovarian cancer and had harbored the same germline mutation. Ectopically expressed mutant BRCA1 protein interacted with the BARD1 protein, but showed a reduced transcriptional function, as de...
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Invasive Micropapillary Carcinoma in Axillary Ectopic Breast and Synchronous Ductal Carcinoma In Situ in the Contralateral Breast.
Authors: Oh SW, Lim HS, Lee JS, Moon SM, Park MH Abstract The development of ectopic breast tissue is attributable to the failure of primitive mammary tissue to regress after the development of the mammary ridge, except at pectoral breast sites, and is most often evident in the axillae. Several benign and malignant breast diseases have been reported in ectopic axillary breast tissues. The most common cancerous pathology of ectopic breast tissue is invasive ductal carcinoma. Ectopic breast cancer presenting with simultaneous primary cancer of the pectoral breast is extremely rare. Herein, we report an invasive micro...
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Erratum: Imaging Surveillance for Survivors of Breast Cancer: Correlation between Cancer Characteristics and Method of Detection.
Authors: Chu AJ, Chang JM, Cho N, Moon WK Abstract [This corrects the article on p. 192 in vol. 20, PMID: 28690656.]. PMID: 28970860 [PubMed] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - October 5, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Recent Advances in the Neoadjuvant Treatment of Breast Cancer.
Authors: Rubovszky G, Horváth Z Abstract In the last few decades, neoadjuvant therapy for breast cancer has gained considerable therapeutic importance. Despite extensive clinical investigations, it has not yet been clarified whether neoadjuvant therapy would result in improved survival in comparison with the standard adjuvant setting in any subgroups of patients with breast cancer. Chemotherapy is especially effective in the treatment of endocrine insensitive tumors, and such ther-apeutic benefit can be assumed for patients with triple-negative, or hormone receptor-negative and human epidermal growth factor ...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis.
Authors: Shen G, He P, Mao Y, Li P, Luh F, Ding G, Liu X, Yen Y Abstract PURPOSE: Uridine-cytidine kinase (UCK) 2 is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynthesis. Recent studies have shown that UCK2 is overexpressed in many types of cancer and may play a crucial role in activating antitumor prodrugs in human cancer cells. In the current study, we evaluated the potential prognostic value of UCK2 in breast cancer. METHODS: We searched public databases to explore associations between UCK2 gene expression and clinical parameters in patients with breast cancer. Gene se...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

CD49f Can Act as a Biomarker for Local or Distant Recurrence in Breast Cancer.
CONCLUSION: Our results indicated that breast tumors with CD49f(+) cancer cells are associated with an increased risk for disease recurrence after initial surgery with poor clinical outcomes (decreased DFS). Therefore, as it requires testing for only one additional protein, adding CD49f testing to conventional surgical pathology is a strategy that has great potential for prognostic and treatment-guidance purposes. PMID: 28690650 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Mutations of the Epidermal Growth Factor Receptor Gene in Triple-Negative Breast Cancer.
CONCLUSION: No activating mutation of EGFR gene of clinical significance was observed in 148 TNBC cases using three commercially available methods. Thus, EGFR gene mutation appears to be an extremely rare event in patients with TNBC. PMID: 28690651 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Impact of Progesterone Receptor Status in Chinese Estrogen Receptor Positive Invasive Breast Cancer Patients.
Authors: Yao N, Song Z, Wang X, Yang S, Song H Abstract PURPOSE: Estrogen receptor (ER) and progesterone receptor (PR) have been used as indicators of endocrine system status since the mid-1970s in the clinical management of breast cancer. The predictive role of ER in endocrine therapy is undisputed, but the prognostic value of PR is still debated. The aim of this study was to investigate the clinical characteristics and prognosis of ER positive breast cancer with different PR expression levels. METHODS: A population cohort of 3,030 primary invasive ER positive breast cancer patients from a single cancer center...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

High Histologic Grade and High Ki-67 Expression Predict Phenotypic Alterations in Node Metastasis in Primary Breast Cancers.
Authors: Mandó P, Rizzo M, de la Puente CP, Maino M, Ponce C, Pombo MT, Amat M, Costanzo MV, Nervo A, Nadal J, Fabiano V, Loza J, Loza CM, Colo F, Reinaldo C Abstract PURPOSE: Several studies have shown that estrogen receptor (ER) and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER2) expression may vary during tumoral progression. We aimed to describe and compare ER, PR, and HER2 expressions in primary breast tumors and synchronic axillary nodal metastases, and evaluate phenotypic correlations between them. METHODS: Patients were identified prospectively through su...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

The Usefulness of Intraoperative Circumferential Frozen-Section Analysis of Lumpectomy Margins in Breast-Conserving Surgery.
CONCLUSION: The IOCFS analysis during BCS is useful in evaluating lumpectomy margins and preventing reoperation. PMID: 28690654 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Screening Uptake Differences Are Not Implicated in Poorer Breast Cancer Outcomes among Singaporean Malay Women.
This study was undertaken to examine the impact of screening and race on breast cancer outcomes in Singapore. METHODS: An institutional database was reviewed, and invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS) data were analyzed separately. Overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were assessed. RESULTS: The study included 6,180 IDC and 1,031 DCIS patients. The median follow-up time was 4.1 years. Among IDC patients, Malay women were the youngest when first diagnosed, and were more likely to present with advanced stage disease. Malay women also had ...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Imaging Surveillance for Survivors of Breast Cancer: Correlation between Cancer Characteristics and Method of Detection.
CONCLUSION: Most recurrent breast cancers showed the same cancer subtype as the primary tumor, and recurrent breast cancer subtypes correlated with the detection modality. Imaging surveillance of survivors of breast cancer might be more beneficial in cases of HR+HER2- type breast cancer or HER2+ type breast cancer than in cases of triple-negative type breast cancer. PMID: 28690656 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Epigenetic Silencing of MORT Is an Early Event in Cancer and Is Associated with Luminal, Receptor Positive Breast Tumor Subtypes.
This study evaluated the epigenetic and transcriptional state of MORT in two premalignant conditions-ductal carcinomas in situ and colon adenomas. Results show that MORT silencing is an early epigenetic event in human carcinogenesis, likely occurring near the point where premalignant cells gain immortality; this epigenetic silencing is maintained throughout malignant transformation and metastatic growth. Additional associations between MORT loss and clinical and molecular features of breast tumors showed that silencing of MORT occurs predominantly in luminal, receptor-positive breast cancer; is associated with overexpressi...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Influence of the Angelina Jolie Announcement and Insurance Reimbursement on Practice Patterns for Hereditary Breast Cancer.
Authors: Lee J, Kim S, Kang E, Park S, Kim Z, Lee MH, Korean Breast Cancer Society Abstract Lack of awareness, the stigma of carrying a genetic mutation, and economic factors are barriers to acceptance of BRCA genetic testing or appropriate risk management. We aimed to investigate the influence of Angelina Jolie's announcement of her medical experience and also health insurance reimbursement for BRCA gene testing on practice patterns for hereditary breast and ovarian cancer (HBOC). A survey regarding changes in practice patterns for HBOC before and after the announcement was conducted online. The rate of BRCA gene ...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Chronic Myeloid Leukemia with a Complex Variant 'Ph' Translocation That Develops in Breast Carcinoma, Postchemotherapy: A Rare but Treatable Entity.
We report a case of chronic myeloid leukemia (CML) that developed after postoperative chemotherapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) for breast cancer. A 55-year-old woman was diagnosed with invasive ductal carcinoma which was treated with a modified radical mastectomy followed by six cycles of CAF chemotherapy. Nine years later, she developed CML and locoregional recurrence. Her breast recurrence showed strong estrogen receptor, weak progesterone receptor and strong human epidermal growth factor 2 (score 3+) expression. Her secondary CML in the chronic phase showed a complex variant translocation...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

A Case of Breast Cancer Brain Metastasis with a 16-Year Time Interval without Evidence of Cancer Recurrence.
Authors: Yamada SM, Tomita Y, Shibui S, Kurokawa T, Baba Y Abstract The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemotherapy for uterine and breast cancer 24 years prior and 16 years prior, respectively. Although she had not received any anticancer treatment for 10 years, no recurrences were identified using whole body scans. A partial tumor resection was...
Source: Journal of Breast Cancer - July 12, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Basic Facts of Breast Cancer in Korea in 2014: The 10-Year Overall Survival Progress.
Authors: Park EH, Min SY, Kim Z, Yoon CS, Jung KW, Nam SJ, Oh SJ, Lee S, Park BW, Lim W, Hur MH, Korean Breast Cancer Society Abstract We, the Korean Breast Cancer Society (KBCS), present the facts and the trends of breast cancer in Korea in 2014. Data on the total number of newly diagnosed patients was obtained from the Korea Central Cancer Registry database, other data were collected from the KBCS online registry database, and the overall survival data of patients were updated from Statistics Korea. A total of 21,484 female patients were newly diagnosed with breast cancer in 2014. The crude incidence rate and the...
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Detection of Methylated Circulating DNA as Noninvasive Biomarkers for Breast Cancer Diagnosis.
Authors: Cheuk IW, Shin VY, Kwong A Abstract Internationally, breast cancer is the most common female cancer, and is induced by a combination of environmental, genetic, and epigenetic risk factors. Despite the advancement of imaging techniques, invasive sampling of breast epithelial cells is the only definitive diagnostic procedure for patients with breast cancer. To date, molecular biomarkers with high sensitivity and specificity for the screening and early detection of breast cancer are lacking. Recent evidence suggests that the detection of methylated circulating cell-free DNA in the peripheral blood of patients...
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Inhibition of Nicotinamide Phosphoribosyltransferase Induces Apoptosis in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells.
CONCLUSION: Results showed that FK866 could effectively inhibit NAD(+) biosynthesis and induce programmed cell death in MCF-7 cells, suggesting that NAMPT inhibitors may be useful for the treatment of ER-positive breast cancers. PMID: 28382091 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Genetic Predisposition of Polymorphisms in HMGB1-Related Genes to Breast Cancer Prognosis in Korean Women.
CONCLUSION: The results of the present study indicate that genetic polymorphisms in HMGB1-related genes are related to breast cancer prognosis in Korean women. PMID: 28382092 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

MicroRNA-222 Expression as a Predictive Marker for Tumor Progression in Hormone Receptor-Positive Breast Cancer.
CONCLUSION: This study showed that miR-222 is associated with down-regulation of the estrogen receptor, EMT, and tumor progression in hormone receptor-positive breast cancer, indicating that miR-222 might be associated with endocrine therapy resistance and poor clinical outcome in hormone receptor-positive breast cancer. PMID: 28382093 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Clinicopathologic and Prognostic Significance of Transducin-Like Enhancer of Split 1 Protein Expression in Invasive Breast Cancer.
Authors: Lee JH, Bae SB, Oh MH, Cho HD, Jang SH, Hong SA, Cho J, Kim SY, Han SW, Lee JE, Kim HJ, Lee HJ Abstract PURPOSE: Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes. We investigated the prognostic significance of TLE1 protein expression in breast cancers by using immunohistochemistry and explored the relationship of TLE1 with clinicopathological parameters. METHODS: Immunohistochemistry was performed on 456 cases of breast cancer tiled on tissue microarrays. The relationship between TLE1 expres...
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

Prognostic Influence of BCL2 on Molecular Subtypes of Breast Cancer.
Authors: Hwang KT, Han W, Kim J, Moon HG, Oh S, Song YS, Kim YA, Chang MS, Noh DY Abstract PURPOSE: We aimed to reveal the prognostic influence of B-cell CLL/lymphoma 2 (BCL2) on molecular subtypes of breast cancer. METHODS: We analyzed 9,468 patients with primary breast cancer. We classified molecular subtypes according to the National Comprehensive Cancer Network (NCCN) and St. Gallen guidelines, mainly on the basis of the expression of hormonal receptor (HR), human epidermal growth factor receptor 2 (HER2), and Ki-67. RESULTS: Regarding NCCN classification, BCL2 was a strong favorable prognostic factor i...
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research

A Prognostic Model for Patients with Triple-Negative Breast Cancer: Importance of the Modified Nottingham Prognostic Index and Age.
CONCLUSION: The MNPI could be used to stratify patients with stage I to III TNBC according to prognosis. It was the most important prognosticator for both DFS and OS. The prognostic significance of young age for DFS differed by MNPI. PMID: 28382096 [PubMed - in process] (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 8, 2017 Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research