Selective Avoidance of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Human Epidermal Growth Factor 2-Positive/Triple-Negative Breast Cancer Patients With Excellent Response
DISCUSSION: Several clinical trials are currently underway to determine whether SLNB can be omitted after NACT in patients with HER2+ BC or TNBC that are expected to achieve pathologic complete response. The ASLAN trial is expected to provide valuable clues regarding the feasibility of omitting axillary surgery in highly selected patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04993625. Registered on August 6, 2021. Clinical Research Information Service Identifier: KCT0006371. Registered on July 22, 2021.PMID:38685868 | DOI:10.4048/jbc.2023.0264 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Jai Min Ryu Hyunjun Lee Wonshik Han Han-Byoel Lee Sung Gwe Ahn Hee Jeong Kim Hyung Seok Park Ji Soo Choi Haeyoung Kim Won Kyung Cho Jeong Eon Lee Source Type: research
Effect of surgical volume on short-term outcomes of cytoreductive surgery for advanced-stage ovarian cancer: A population-based study from the Dutch Gynecological Oncology Audit
CONCLUSIONS: Our analyses do not support further centralization of iCRS for advanced-stage OC. High-volume was associated with higher complete pCRS, suggesting either a more accurate selection in these hospitals or a more aggressive approach. The higher completeness rates were at the expense of higher severe complications and prolonged admissions.PMID:38688188 | DOI:10.1016/j.ygyno.2024.04.002 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 30, 2024 Category: Cancer & Oncology Authors: M D Algera W J van Driel B F M Slangen M W J M Wouters R F P M Kruitwagen participants of the Dutch Gynecological Oncology Audit Collaborator Group Source Type: research
Deciphering resistance mechanisms and novel strategies to overcome drug resistance in ovarian cancer: a comprehensive review
Oncol Res. 2024 Apr 23;32(5):831-847. doi: 10.32604/or.2024.031006. eCollection 2024.ABSTRACTOvarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for ma...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Effat Alemzadeh Leila Allahqoli Afrooz Mazidimoradi Esmat Alemzadeh Fahimeh Ghasemi Hamid Salehiniya Ibrahim Alkatout Source Type: research
A comparative < em > in vitro < /em > study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells
This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in intra...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Shahid Karim Alanoud Naher Alghanmi Maha Jamal Huda Alkreathy Alam Jamal Hind A Alkhatabi Mohammed Bazuhair Aftab Ahmad Source Type: research
A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
Oncol Res. 2024 Apr 23;32(5):849-875. doi: 10.32604/or.2024.047042. eCollection 2024.ABSTRACTGlioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12-15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Nilam Bhusare Maushmi Kumar Source Type: research
Rational treatment options for T1/2N0M0 squamous cell carcinoma of the anal canal: a population-based study combined with external validation
CONCLUSION: The nomogram developed in this study effectively and comprehensively evaluated the prognosis of patients with cT1/2N0M0 squamous cell carcinoma of the anal canal. Local excision is recommended for low risk patients, radiotherapy for moderate-risk patients, and radiotherapy or chemoradiotherapy for high-risk patients.PMID:38688457 | DOI:10.1093/oncolo/oyae068 (Source: The Oncologist)
Source: The Oncologist - April 30, 2024 Category: Cancer & Oncology Authors: Xue Shao Qiulei Zhang Ying Huo Chang Lu Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
CONCLUSIONS: KCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC.PMID:38689322 | DOI:10.1186/s40001-024-01844-1 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Wei Zhang Xiao-Song Chen Ying Wei Xiao-Min Wang Xian-Jin Chen Bang-Teng Chi Lin-Qing Huang Rong-Quan He Zhi-Guang Huang Qi Li Gang Chen Juan He Mei Wu Source Type: research
In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells
Biol Trace Elem Res. 2024 Apr 30. doi: 10.1007/s12011-024-04188-3. Online ahead of print.ABSTRACTMedullary thyroid cancer (MTC) is a highly aggressive and chemotherapy-resistant cancer originating from the thyroid's parafollicular C cells. Due to its resistance to conventional treatments, alternative therapies such as boric acid have been explored. Boric acid, a boron-based compound, has shown anticarcinogenic effects, positioning it as a potential treatment option for MTC. TT medullary thyroid carcinoma cell line (TT cells) and human thyroid fibroblast (HThF cells) were utilized for the cell culture experiments. Cell viab...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Onurcan Y ıldırım M ücahit Seçme Yavuz Dodurga G ülçin Abban Mete Semin Melahat Fenkci Source Type: research
Failure to Undergo Resection Following Neoadjuvant Therapy for Resectable Pancreatic Cancer: A Secondary Analysis of SWOG S1505
CONCLUSIONS: Failure to undergo resection following NT was relatively common among patients with potentially resectable PDAC and associated with worse survival. Although few predictive factors were identified in this secondary analysis of the SWOG S1505 randomized trial, further research must focus on risk factors for severe toxicities during NT that preclude surgical resection so that patient-centered interventions can be delivered or alternate treatment sequencing can be recommended.PMID:38688309 | DOI:10.6004/jnccn.2023.7099 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 30, 2024 Category: Cancer & Oncology Authors: Jordan M Cloyd Sarah Colby Katherine A Guthrie Andy M Lowy E Gabrielle Chiorean Phillip Philip Davendra Sohal Syed Ahmad Source Type: research
The efficacy of coaxial percutaneous iodine-125 seed implantation combined with arterial infusion chemotherapy for advanced pancreatic cancer: a randomized clinical trial
CONCLUSION: The combination of coaxial percutaneous 125I seed implantation with arterial infusion chemotherapy could significantly alleviate abdominal pain, improve tumor control rates, and prolong survival time in patients with advanced PC.PMID:38687687 | DOI:10.1080/09553002.2024.2347357 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - April 30, 2024 Category: Radiology Authors: HongXiang Yao Ying ZhuGe ShiXiang Jin ShuiBing Chen HengYiTing Zhang Dong Zhang ZhiGang Chen Source Type: research
Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy
CONCLUSION: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.PMID:38685733 | PMC:PMC11058424 | DOI:10.3348/kjr.2023.0985 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Yubo Guo Xiao Li Yajuan Gao Kaini Shen Lu Lin Jian Wang Jian Cao Zhuoli Zhang Ke Wan Xi Yang Zhou Yucheng Chen Long Jiang Zhang Jian Li Yining Wang Source Type: research
Association of pathological response with long-term survival outcomes after neoadjuvant immunotherapy: A meta-analysis
CONCLUSION: Our meta-analysis demonstrates a strong association between pathological response and long-term survival outcomes at patient level across studies applying neoadjuvant immunotherapy in most solid tumors but we fail to validate the relationship at trial level. Therefore, an accepted surrogate endpoint applied to both patient and trial levels are waited for further search.PMID:38685176 | DOI:10.1016/j.intimp.2024.112078 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Chenyu Wei Haolin Sun Jiexuan Hu Zhongjun Ma Bangwei Cao Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Journal of Applied Clinical Medical Physics - April 30, 2024 Category: Physics Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
Doxycycline, levofloxacin, and moxifloxacin are superior to ciprofloxacin in treating anthrax meningitis in rabbits and NHP
Antimicrob Agents Chemother. 2024 Apr 30:e0161023. doi: 10.1128/aac.01610-23. Online ahead of print.ABSTRACTEfficient treatment of anthrax-related meningitis in patients poses a significant therapeutic challenge. Previously, we demonstrated in our anthrax meningitis rabbit model that ciprofloxacin treatment is ineffective with most of the treated animals succumbing to the infection. Herein we tested the efficacy of doxycycline in our rabbit model and found it highly effective. Since all of our findings are based on a rabbit model, we test the efficacy of ciprofloxacin or doxycycline in a specific central nervous system (CN...
Source: Antimicrobial Agents and Chemotherapy - April 30, 2024 Category: Microbiology Authors: Amir Ben-Shmuel Itai Glinert Assa Sittner Elad Bar-David Josef Schlomovitz Haim Levy Shay Weiss Source Type: research
