New advances in the treatment of chondrosarcoma under the PD-1/PD-L1 pathway
J Cancer Res Ther. 2024 Apr 1;20(2):522-530. doi: 10.4103/jcrt.jcrt_2269_23. Epub 2024 Apr 30.ABSTRACTBone sarcomas encompass a group of spontaneous mesenchymal malignancies, among which osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma are the most common subtypes. Chondrosarcoma, a relatively prevalent malignant bone tumor that originates from chondrocytes, is characterized by endogenous cartilage ossification within the tumor tissue. Despite the use of aggressive treatment approaches involving extensive surgical resection, chemotherapy, and radiotherapy for patients with osteosarcoma, chondrosarcoma, and chordom...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jiawei Yin Peng Ren Source Type: research
Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer
Cancer Res Commun. 2024 Apr 24;4(4):1120-1134. doi: 10.1158/2767-9764.CRC-23-0468.ABSTRACTCombinations of immune checkpoint inhibitors (ICI, including anti-PD-1/PD-L1) and chemotherapy have been FDA approved for metastatic and early-stage triple-negative breast cancer (TNBC), but most patients do not benefit. B7-H4 is a B7 family ligand with proposed immunosuppressive functions being explored as a cancer immunotherapy target and may be associated with anti-PD-L1 resistance. However, little is known about its regulation and effect on immune cell function in breast cancers. We assessed murine and human breast cancer cells to...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Elizabeth C Wescott Xiaopeng Sun Paula Gonzalez-Ericsson Ann Hanna Brandie C Taylor Violeta Sanchez Juliana Bronzini Susan R Opalenik Melinda E Sanders Julia Wulfkuhle Rosa I Gallagher Henry Gomez Claudine Isaacs Vijaya Bharti John T Wilson Tarah J Ballin Source Type: research
A comparative < em > in vitro < /em > study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells
This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in intra...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Shahid Karim Alanoud Naher Alghanmi Maha Jamal Huda Alkreathy Alam Jamal Hind A Alkhatabi Mohammed Bazuhair Aftab Ahmad Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Journal of Applied Clinical Medical Physics - April 30, 2024 Category: Physics Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
circIARS: a potential plasma biomarker for diagnosing non-small cell lung cancer
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 29. doi: 10.3724/abbs.2024043. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC) is one of the most prevalent cancers in the world, and early diagnosis can effectively improve patient survival. Here, differentially expressed circIARS genes are screened from the sequencing results, and their molecular characteristics are examined by Sanger sequencing, RNase R assay, agarose gel electrophoresis (AGE), and fluorescence in situ hybridization (FISH). Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) is performed to detect the expression level of ...
Source: Acta Biochimica et Biophysica Sinica - April 30, 2024 Category: Biochemistry Authors: Qi Zhang Xinfeng Fan Xinyu Zhang Shaoqing Ju Source Type: research
Synchronous Double Primary Angiosarcoma Originating from the Stomach and Rectum: A Case Report and a Literature Review
Arch Iran Med. 2024 Mar 1;27(3):168-173. doi: 10.34172/aim.2024.25.ABSTRACTAngiosarcomas originating from the gastrointestinal tract are rare but highly aggressive tumors with poor prognosis. These tumors can be misdiagnosed as benign and malignant gastrointestinal tract lesions. The definitive histological diagnosis of angiosarcomasis made by pathologists based on immunohistochemical analysis demonstrating cluster of differentiation 31 (CD31), factor VIII-related antigen (FVIIIRAg), erythroblast transformation specific related gene (ERG), and cluster of differentiation 34 (CD34). Angiosarcomas are treated with a single or...
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Tanju Kapagan Nilufer Bulut Gokmen Umut Erdem Suleyman Y ıldırım Zeynep Betul Erdem Halil Sahin Source Type: research
Neoadjuvant Chemotherapy in Patients with HER2-Negative Breast Cancer: A Report from Clinical Breast Cancer Registry of Iran
CONCLUSION: This study provides further evidence that NCT is a viable treatment option for patients with HER2-negative BC. The TAC regimen resulted in a significantly higher pCR rate compared to other regimens, but did not result in a significant improvement in recurrence, OS and DFS and rates.PMID:38685847 | DOI:10.34172/aim.2024.30 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Kamran Roudini Mehrzad Mirzania Tahereh Yavari Monireh Sadat Seyyedsalehi Azin Nahvijou Jayran Zebardast Mina Saadat Ahmad Khajeh-Mehrizi Source Type: research
Hepatic arterial infusion chemotherapy, lenvatinib plus programmed cell death protein ‐1 inhibitors: A promising treatment approach for high‐burden hepatocellular carcinoma
ConclusionThe combination of HAIC-FOLFOX with lenvatinib and PD-1 inhibitors as a first-line therapy has exhibited notable therapeutic efficacy and well-tolerated adverse events among patients with high-burden HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 30, 2024 Category: Cancer & Oncology Authors: Shumin Fu,
Yongkang Xu,
Ye Mao,
Mengting He,
Zhimeng Chen,
Shenglan Huang,
Dan Li,
Yaqin Lv,
Jianbing Wu Tags: RESEARCH ARTICLE Source Type: research
GSE262596 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma (eIF6_KD)
This study sheds light on eIF6's potential therapeutic interventions to mitigate treatment resistance in SCLC. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE262593 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma (SCLC cell lines)
This study sheds light on eIF6's potential therapeutic interventions to mitigate treatment resistance in SCLC. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE261684 STC1 promotes temozolomide resistance of glioblastoma through STAT3-mediated regulation of MGMT.
Contributors : Chao Duan ; Bincan He ; Zhiqiang DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to temozolomide (TMZ) is one of the major challenges for glioblastoma (GBM) therapy while the underlying mechanisms demand further exploration. Tumor-repopulating cells (TRCs) have been proven to be involved in chemotherapy resistentce. We first enriched GBM TRCs by culturing DBTRG cells in 3D soft fibrin gels and performed RNA-seq. By anlyzing the differentially expressed genes (DEGs) between TRCs and 2D conventionally cultured DBTRG cells, we identified the glycoprotein ...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Hepatitis B virus reactivation in hepatocellular carcinoma patients after hepatic arterial infusion chemotherapy combined with and without immunotherapy
Hepatitis B virus (HBV) reactivation (HBVr) is a major concern for hepatocellular carcinoma (HCC) patients undergoing hepatic arterial infusion chemotherapy (HAIC) using mFOLFOX6 regimen. There is insufficient... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Lijie Zhang, Yiming Liu, Songlin Song, Joyman Makamure, Heshui Shi, Chuansheng Zheng and Bin Liang Tags: Research Source Type: research
Letter to the Editor Regarding Article “Prior to Initiation of Chemotherapy, Can We Predict Breast Tumor Response? Deep Learning Convolutional Neural Networks Approach Using a Breast MRI Tumor Dataset”
AbstractThe cited article reports on a convolutional neural network trained to predict response to neoadjuvant chemotherapy from pre-treatment breast MRI scans. The proposed algorithm attains impressive performance on the test dataset with a mean Area Under the Receiver-Operating Characteristic curve of 0.98 and a mean accuracy of 88%. In this letter, I raise concerns that the reported results can be explained by inadvertent data leakage between training and test datasets. More precisely, I conjecture that the random split of the full dataset in training and test sets did not occur on a patient level, but rather on the lev...
Source: Journal of Digital Imaging - April 30, 2024 Category: Radiology Source Type: research
Feasibility of laparoscopic/robot-assisted surgery for Borrmann type 4 gastric cancer: a comparison study with conventional open surgery
ConclusionWhile multidisciplinary treatment is mainstay of treatment because of the poor prognosis of this disease, minimally invasive surgery may play an important role in treatment if appropriate patient selection is done. Further analyses with larger sample size are necessary to reach a final conclusion regarding oncological efficacy. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 30, 2024 Category: Surgery Source Type: research
Predicting response of hepatoblastoma primary lesions to neoadjuvant chemotherapy through contrast-enhanced computed tomography radiomics
ConclusionCECT radiomics has the potential to predict primary lesion response to neoadjuvant chemotherapy in hepatoblastoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
