Prognostic factors and significance of postoperative adjuvant chemotherapy in patients with advanced gastric cancer undergoing neoadjuvant chemotherapy followed by gastrectomy
ConclusionsypN status and postoperative adjuvant chemotherapy were independent prognostic factors in gastric cancer patients who underwent NAC followed by curative gastrectomy. It is important to maintain the patient ’s condition during NAC and the perioperative period so that they can receive postoperative adjuvant chemotherapy. (Source: Surgery Today)
Source: Surgery Today - April 28, 2024 Category: Surgery Source Type: research
Functional decline in older breast cancer survivors treated with and without chemotherapy and non-cancer controls: results from the Hurria Older PatiEnts (HOPE) prospective study
ConclusionIn this cohort of older adults with early-stage breast cancer, the combination of breast cancer and chemotherapy contributes to accelerated functional decline. Our findings reinforce the need to develop interventions aimed at preserving physical function, particularly during and after chemotherapy.Implications for Cancer SurvivorsThe high prevalence of accelerated functional decline in older women undergoing breast cancer chemotherapy underscores the urgency to develop interventions aimed at preserving physical function and improving health outcomes.Clinical TrialNCT01472094, Hurria Older PatiEnts (HOPE) with Bre...
Source: Journal of Cancer Survivorship - April 28, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1719: The Role of Surgery in Pleural Mesothelioma
ler
Surgery plays a central role in the diagnosis, staging, and management of pleural mesothelioma. Achieving an accurate diagnosis through surgical intervention and identifying the specific histologic subtype is crucial for determining the appropriate course of treatment. The histologic subtype guides decisions regarding the use of chemotherapy, immunotherapy, or multimodality treatment. The goal of surgery as part of multimodality treatment is to accomplish macroscopic complete resection with the eradication of grossly visible and palpable disease. Over the past two decades, many medical centers worldwide have shifte...
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Moshe Lapidot Martin Sattler Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1718: Safety and Effectiveness of Perioperative Hyperthermic Intraperitoneal Chemotherapy with Gemcitabine in Patients with Resected Pancreatic Ductal Adenocarcinoma: Clinical Trial EudraCT 2016-004298-41
Conclusions: The use of HIPEC with gemcitabine after surgery in patients with resectable pancreatic ductal adenocarcinoma reduces locoregional recurrence and may be associated with a significant decrease in pancreatic cancer stem cells. (Source: Cancers)
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: David Padilla-Valverde Raquel Bodoque-Villar Esther Garc ía-Santos Susana Sanchez Carmen Manzanares-Campillo Marta Rodriguez Lucia Gonz ález Alfonso Ambr ós Juana M. Cano Maria Padilla-Marcote Javier Redondo-Calvo Jesus Martin Leticia Serrano-Oviedo Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1721: Textbook Neoadjuvant Outcome & mdash;Novel Composite Measure of Oncological Outcomes among Gastric Cancer Patients Undergoing Multimodal Treatment
Cancers, Vol. 16, Pages 1721: Textbook Neoadjuvant Outcome—Novel Composite Measure of Oncological Outcomes among Gastric Cancer Patients Undergoing Multimodal Treatment
Cancers doi: 10.3390/cancers16091721
Authors:
Zuzanna Pelc
Katarzyna Sędłak
Magdalena Leśniewska
Katarzyna Mielniczek
Katarzyna Chawrylak
Magdalena Skórzewska
Tomasz Ciszewski
Joanna Czechowska
Agata Kiszczyńska
Bas P. L. Wijnhoven
Johanna W. Van Van Sandick
Ines Gockel
Suzanne S. Gisbertz
Guillaume Piessen
Clarisse Eveno
Maria Bencivenga
Giovanni De Manzoni
Gian Luca Baiocchi
Paolo Morgagni
Riccardo ...
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Zuzanna Pelc Katarzyna S ędłak Magdalena Le śniewska Katarzyna Mielniczek Katarzyna Chawrylak Magdalena Sk órzewska Tomasz Ciszewski Joanna Czechowska Agata Kiszczy ńska Bas P. L. Wijnhoven Johanna W. Van Van Sandick Ines Gockel Suzanne S. Gisbertz G Tags: Review Source Type: research
Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073296206240416060154. Online ahead of print.ABSTRACTChemotherapy resistance is a common cause of tumor treatment failure. Various molecular responses, such as increased expression of efflux transporter proteins, including Pglycoprotein (P-gp), changes in the tumor microenvironment (TME), the role of platelets, and the effects of cancer stem cells (CSCs), can lead to drug resistance. Through extensive research on the mechanisms of drug resistance, more effective anti-resistance drugs and therapeutic approaches are being developed. This review explores drug ...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yun Liu Xinyu Sun Chen Wei Shoudong Guo Chunxiao Song Jiangyu Zhang Jingkun Bai Source Type: research
Preparation and bioevaluation of a novel < sup > 99m < /sup > Tc-labelled propylene amine oxime (PnAO) containing two 4-methyl-2-nitroimidazole groups as a promising tumor hypoxia imaging agent
Bioorg Med Chem Lett. 2024 Apr 25;106:129773. doi: 10.1016/j.bmcl.2024.129773. Online ahead of print.ABSTRACTHypoxia is a common phenomenon in solid tumors, and its presence inhibits the efficacy of tumor chemotherapy and radiotherapy. Accurate measurement of hypoxia before tumor treatment is essential. Three propylene amine oxime (PnAO) derivatives with different substituents attached to 2-nitroimidazole were synthesized in the work, they are 3,3,9,9-tetramethyl-1,11-bis(4-bromo-2-nitro-1H-imidazol-1-yl)-4,8-diazaundecane-2,10-dione dioxime (Br2P2), 3,3,9,9-tetramethyl-1,11-bis(4-methyl-2-nitro-1H-imidazol-1-yl)-4,8-diaza...
Source: Bioorganic and Medicinal Chemistry Letters - April 27, 2024 Category: Chemistry Authors: Shuo Li Taiwei Chu Source Type: research
Management of Oligometastatic Colorectal Cancer
Surg Clin North Am. 2024 Jun;104(3):619-629. doi: 10.1016/j.suc.2023.11.011. Epub 2023 Dec 11.ABSTRACTThe management of oligometastatic colorectal cancer differs from the treatment of metastatic colorectal cancer, and it is essential that those who treat oligometastatic disease be familiar with the treatment options for these patients. Although definitive treatment is often surgical, there are situations where local therapies such as SBRT or ablative techniques may better serve the patient. Adjuvant therapy should be provided to all patients, and neoadjuvant chemotherapy should be considered as well. The role of immunother...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Camille R Suydam Andrew T Schlussel Source Type: research
Total Neoadjuvant Therapy for Rectal Cancer
Surg Clin North Am. 2024 Jun;104(3):609-617. doi: 10.1016/j.suc.2023.11.010. Epub 2024 Feb 12.ABSTRACTThe treatment of locally advanced rectal cancer has traditionally included sequenced multimodal therapy including radiation, chemotherapy, and surgery. The relative contribution of each and the order of treatments have evolved over the years. By the early twenty-first century, there was widespread use of the German Rectal Cancer Trial approach: preoperative chemoradiation, followed by standardized surgery including total mesorectal excision, and finally adjuvant chemotherapy. Recent advances have defined the superiority of...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Arthur G Affleck Daniel Herzig Source Type: research
Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level
Conclusions: It was predicted that the increased expression of the MKi67 gene by TAA leads to the increase in TP53, which negatively regulates the cell cycle via increased CDKN3 expression in kidneys and the restoration of TP53 levels in the liver. These findings contribute to our understanding of the effects of olmutinib and WGO on TAA-induced gene expression changes and highlight their contrasting effects based on cell cycle alterations.PMID:38674285 | PMC:PMC11052166 | DOI:10.3390/medicina60040639 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Seema Zargar Tanveer A Wani Salman Alamery Fatimah Yaseen Source Type: research
Impact of Combination Therapy with Chemical Drugs and Megavoltage X-ray Exposure on Breast Cancer Stem Cells' Viability and Proliferation of MCF-7 and MDA-MB-231 Cell Lines
CONCLUSION: Anti-cancer and cytotoxic effects of metformin can be effective in this strategy. In conclusion, the combination of conventional chemotherapeutic drugs, including SB203580, metformin, and takinib with X-ray exposure can be a new approach to diminish the drug resistance of breast cancer.PMID:38676476 | DOI:10.2174/0113816128287325240329085055 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Fatemeh Banisharif Dehkordi Mahdi Ghatrehsamani Maryam Abdolvand Amin Soltani Seyed Hossein Masoumi Source Type: research
The multidisciplinary management of locally advanced rectal cancer
Expert Rev Anticancer Ther. 2024 Apr 26. doi: 10.1080/14737140.2024.2349137. Online ahead of print.ABSTRACTINTRODUCTION: . The classic paradigm for the management of locally advanced rectal cancer (LARC) consists of (chemo)radiotherapy (C)RT), total mesorectal excision and adjuvant chemotherapy (CHT). At present, due to the high rate of distant metastasis (up to 30%), the total neoadjuvant therapy (TNT) with the administration of systemic CHT in the neoadjuvant setting has gained acceptance as standard of care.Our aim is to critically review current literature on LARC management and summarize the different approaches recen...
Source: Expert Review of Anticancer Therapy - April 27, 2024 Category: Cancer & Oncology Authors: Francesca De Felice Michelangelo Miccini Andrea Botticelli Michela Roberto Niccol ò Petrucciani Source Type: research
Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells
This study reveals that human umbilical cord-derived MSCs (hUC-MSCs) can protect ovarian granulosa cells (GCs) from cyclophosphamide (CTX)-induced ferroptosis, a form of cell death driven by iron accumulation. CTX, commonly used to induce POI animal model, triggered ferroptosis in GCs, while hUC-MSCs treatment mitigated this effect, both in vivo and in vitro. Further investigations using ferroptosis and autophagy inhibitors suggest that hUC-MSCs act by suppressing ferroptosis in GCs. Interestingly, hUC-MSCs activate a protective antioxidant pathway in GCs via NRF2, a stress-response regulator. Overall, our findings suggest...
Source: Free Radical Biology and Medicine - April 27, 2024 Category: Biology Authors: Wenjie Dai Bo Xu Liyang Ding Zhen Zhang Hong Yang Tiantian He Ling Liu Xiuying Pei Xufeng Fu Source Type: research
Preparation and bioevaluation of a novel < sup > 99m < /sup > Tc-labelled propylene amine oxime (PnAO) containing two 4-methyl-2-nitroimidazole groups as a promising tumor hypoxia imaging agent
Bioorg Med Chem Lett. 2024 Apr 25;106:129773. doi: 10.1016/j.bmcl.2024.129773. Online ahead of print.ABSTRACTHypoxia is a common phenomenon in solid tumors, and its presence inhibits the efficacy of tumor chemotherapy and radiotherapy. Accurate measurement of hypoxia before tumor treatment is essential. Three propylene amine oxime (PnAO) derivatives with different substituents attached to 2-nitroimidazole were synthesized in the work, they are 3,3,9,9-tetramethyl-1,11-bis(4-bromo-2-nitro-1H-imidazol-1-yl)-4,8-diazaundecane-2,10-dione dioxime (Br2P2), 3,3,9,9-tetramethyl-1,11-bis(4-methyl-2-nitro-1H-imidazol-1-yl)-4,8-diaza...
Source: Bioorganic and Medicinal Chemistry Letters - April 27, 2024 Category: Chemistry Authors: Shuo Li Taiwei Chu Source Type: research
Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073296206240416060154. Online ahead of print.ABSTRACTChemotherapy resistance is a common cause of tumor treatment failure. Various molecular responses, such as increased expression of efflux transporter proteins, including Pglycoprotein (P-gp), changes in the tumor microenvironment (TME), the role of platelets, and the effects of cancer stem cells (CSCs), can lead to drug resistance. Through extensive research on the mechanisms of drug resistance, more effective anti-resistance drugs and therapeutic approaches are being developed. This review explores drug ...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Yun Liu Xinyu Sun Chen Wei Shoudong Guo Chunxiao Song Jiangyu Zhang Jingkun Bai Source Type: research
