Synchronous Double Primary Angiosarcoma Originating from the Stomach and Rectum: A Case Report and a Literature Review
Arch Iran Med. 2024 Mar 1;27(3):168-173. doi: 10.34172/aim.2024.25.ABSTRACTAngiosarcomas originating from the gastrointestinal tract are rare but highly aggressive tumors with poor prognosis. These tumors can be misdiagnosed as benign and malignant gastrointestinal tract lesions. The definitive histological diagnosis of angiosarcomasis made by pathologists based on immunohistochemical analysis demonstrating cluster of differentiation 31 (CD31), factor VIII-related antigen (FVIIIRAg), erythroblast transformation specific related gene (ERG), and cluster of differentiation 34 (CD34). Angiosarcomas are treated with a single or...
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Tanju Kapagan Nilufer Bulut Gokmen Umut Erdem Suleyman Y ıldırım Zeynep Betul Erdem Halil Sahin Source Type: research
Neoadjuvant Chemotherapy in Patients with HER2-Negative Breast Cancer: A Report from Clinical Breast Cancer Registry of Iran
CONCLUSION: This study provides further evidence that NCT is a viable treatment option for patients with HER2-negative BC. The TAC regimen resulted in a significantly higher pCR rate compared to other regimens, but did not result in a significant improvement in recurrence, OS and DFS and rates.PMID:38685847 | DOI:10.34172/aim.2024.30 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Kamran Roudini Mehrzad Mirzania Tahereh Yavari Monireh Sadat Seyyedsalehi Azin Nahvijou Jayran Zebardast Mina Saadat Ahmad Khajeh-Mehrizi Source Type: research
Hepatic arterial infusion chemotherapy, lenvatinib plus programmed cell death protein ‐1 inhibitors: A promising treatment approach for high‐burden hepatocellular carcinoma
ConclusionThe combination of HAIC-FOLFOX with lenvatinib and PD-1 inhibitors as a first-line therapy has exhibited notable therapeutic efficacy and well-tolerated adverse events among patients with high-burden HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 30, 2024 Category: Cancer & Oncology Authors: Shumin Fu,
Yongkang Xu,
Ye Mao,
Mengting He,
Zhimeng Chen,
Shenglan Huang,
Dan Li,
Yaqin Lv,
Jianbing Wu Tags: RESEARCH ARTICLE Source Type: research
GSE262596 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma (eIF6_KD)
This study sheds light on eIF6's potential therapeutic interventions to mitigate treatment resistance in SCLC. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE262593 EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma (SCLC cell lines)
This study sheds light on eIF6's potential therapeutic interventions to mitigate treatment resistance in SCLC. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE261684 STC1 promotes temozolomide resistance of glioblastoma through STAT3-mediated regulation of MGMT.
Contributors : Chao Duan ; Bincan He ; Zhiqiang DongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to temozolomide (TMZ) is one of the major challenges for glioblastoma (GBM) therapy while the underlying mechanisms demand further exploration. Tumor-repopulating cells (TRCs) have been proven to be involved in chemotherapy resistentce. We first enriched GBM TRCs by culturing DBTRG cells in 3D soft fibrin gels and performed RNA-seq. By anlyzing the differentially expressed genes (DEGs) between TRCs and 2D conventionally cultured DBTRG cells, we identified the glycoprotein ...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Hepatitis B virus reactivation in hepatocellular carcinoma patients after hepatic arterial infusion chemotherapy combined with and without immunotherapy
Hepatitis B virus (HBV) reactivation (HBVr) is a major concern for hepatocellular carcinoma (HCC) patients undergoing hepatic arterial infusion chemotherapy (HAIC) using mFOLFOX6 regimen. There is insufficient... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Lijie Zhang, Yiming Liu, Songlin Song, Joyman Makamure, Heshui Shi, Chuansheng Zheng and Bin Liang Tags: Research Source Type: research
Letter to the Editor Regarding Article “Prior to Initiation of Chemotherapy, Can We Predict Breast Tumor Response? Deep Learning Convolutional Neural Networks Approach Using a Breast MRI Tumor Dataset”
AbstractThe cited article reports on a convolutional neural network trained to predict response to neoadjuvant chemotherapy from pre-treatment breast MRI scans. The proposed algorithm attains impressive performance on the test dataset with a mean Area Under the Receiver-Operating Characteristic curve of 0.98 and a mean accuracy of 88%. In this letter, I raise concerns that the reported results can be explained by inadvertent data leakage between training and test datasets. More precisely, I conjecture that the random split of the full dataset in training and test sets did not occur on a patient level, but rather on the lev...
Source: Journal of Digital Imaging - April 30, 2024 Category: Radiology Source Type: research
Feasibility of laparoscopic/robot-assisted surgery for Borrmann type 4 gastric cancer: a comparison study with conventional open surgery
ConclusionWhile multidisciplinary treatment is mainstay of treatment because of the poor prognosis of this disease, minimally invasive surgery may play an important role in treatment if appropriate patient selection is done. Further analyses with larger sample size are necessary to reach a final conclusion regarding oncological efficacy. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 30, 2024 Category: Surgery Source Type: research
Predicting response of hepatoblastoma primary lesions to neoadjuvant chemotherapy through contrast-enhanced computed tomography radiomics
ConclusionCECT radiomics has the potential to predict primary lesion response to neoadjuvant chemotherapy in hepatoblastoma. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Comparison of Echocardiography and Multi-Planar Gated Acquisition Scans for Predicting Cancer-Treatment-Related Cardiovascular Dysfunction
Current guidelines recommend using sequential cardiac imaging to monitor for cancer treatment-related cardiac dysfunction (CTRCD) in patients undergoing potentially cardiotoxic chemotherapy. Multiple different imaging cardiac modalities are available and there are few prospective head-to-head comparative studies to help guide treatment. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - April 30, 2024 Category: Cardiology Authors: Mark T. Nolan, Faraz Pathan, Louise Nott, Allison Black, Owen Pointon, Thomas H. Marwick Tags: Original Article Source Type: research
Nuanced Management of a Skull Base Tumor in the Setting of Relapsed Acute Lymphoblastic Leukemia
We report the significant effect of chemotherapy and radiotherapy in reducing the size of the extensive skull base lesion, saving the patient from the risks associated with surgery. This patient's initial relapse, with a large skull base lesion that had intracranial involvement, is an unusual presentation of relapsed ALL. The additional early recurrence of leptomeningeal disease further makes this case unique and the management even more nuanced. Here, we demonstrate a multidisciplinary approach for the successful treatment of our patient, which can help guide the management of similar patients in the future. [...] Georg T...
Source: Journal of Neurological Surgery Reports - April 30, 2024 Category: Neurosurgery Authors: Jung, Geena Buckner-Wolfson, Emery Tal, Adit Fatemi, Ryan Kim, Timothy Liriano, Genesis Kobets, Andrew Tags: Case Report Source Type: research
Dynamic change in the peritoneal cancer index based on CT after chemotherapy in the overall survival prediction of gastric cancer patients with peritoneal metastasis
ConclusionCT analysis after chemotherapy could predict OS in patients with GCPM. The CT-PCI change ratio could contribute to the determination of an appropriate strategy for gastric cancer patients with peritoneal metastasis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1755: Activation of the Anaphase Promoting Complex Restores Impaired Mitotic Progression and Chemosensitivity in Multiple Drug-Resistant Human Breast Cancer
Alan Harkness
The development of multiple-drug-resistant (MDR) cancer all too often signals the need for alternative toxic therapy or palliative care. Our recent in vivo and in vitro studies using canine MDR lymphoma cancer cells demonstrate that the Anaphase Promoting Complex (APC) is impaired in MDR cells compared to normal canine control and drug-sensitive cancer cells. Here, we sought to establish whether this phenomena is a generalizable mechanism independent of species, malignancy type, or chemotherapy regime. To test the association of blunted APC activity with MDR cancer behavior, we used matched parental and M...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Mathew Lubachowski Cordell VanGenderen Sarah Valentine Zach Belak Gerald Floyd Davies Terra Gayle Arnason Troy Anthony Alan Harkness Tags: Article Source Type: research
Drug-loaded polymer-coated silver nanoparticles for lung cancer theranostics
AbstractLung cancer is the leading cause of death in cancer across the globe. To minimize these deaths, the replacement of traditional chemotherapy with novel strategies is significant. We have developed a nanotheranostic approach using silver nanoparticles for imaging and treatment. Silver nanoparticles (AgNPs) are fabricated by chemical reduction method. The formulation of AgNPs was confirmed by different characterization techniques like stability test, UV –Visible spectroscopy, Confocal Raman Spectroscopy, and Energy-Dispersive X-ray analysis. Further, AgNPs are coated with poly lactic-co-glycolic acid (PLGA) and then...
Source: Medical Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
