Prognostic Value of Pulmonary Hypertension, Right Ventricular Function and Tricuspid Regurgitation on Mortality After Transcatheter Mitral Valve Repair: A  Systematic Review and Meta-Analysis
Pulmonary hypertension (PH), right ventricular (RV) dysfunction, and tricuspid regurgitation (TR) are commonly present in patients with mitral regurgitation (MR) and known to impair prognosis. This systematic review and meta-analysis aimed to determine the prognostic value of PH, RV function, and TR on mortality after transcatheter mitral valve repair (TMVR). (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 17, 2022 Category: Cardiology Authors: Frank Meijerink, Samme M. de Witte, Jacqueline Limpens, Robbert J. de Winter, Berto J. Bouma, Jan Baan Tags: Original Article Source Type: research

Machine Learning in Paediatric Cardiac Surgery: Ready for Prime Time?
Machine learning (ML) is a branch of artificial intelligence which involves ‘learning’ the complex relationships between predictors and outcomes. Despite wide availability, these techniques have been rarely implemented into everyday clinical practice. The use of ML in paediatric cardiac surgery is even rarer. The time has come to employ ML to develop risk adjustment mod els for patient prognosis and benchmarking as a natural starting point for real-time personalised risk prediction in paediatric cardiac surgery. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 13, 2022 Category: Cardiology Authors: Kim S. Betts, Supreet P. Marathe, Jessica Suna, Prem Venugopal, Kevin Chai, Nelson Alphonso, Queensland Paediatric Cardiac Research (QPCR) Group Tags: Commentary Source Type: research

The Role of Extracellular Matrix in the Experimental Acute Aortic Regurgitation Model in Rats
This study aimed to investigate cardiac morphology and function after 1, 4, 8, and 12 weeks of experimental AR in Wistar rats. Extracellular matrix was also investigated as the potential mechanism that underlies the AR remodelling process. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 13, 2022 Category: Cardiology Authors: Marjory Bussoni, Marina P. Okoshi, Luiz S. Matsubara, Bertha F. Polegato, Meliza G. Roscani, Elenize J. Pereira, Sergio A.R. de Paiva, Leonardo A.M. Zornoff, Katashi Okoshi, Marcos F. Minicucci, Paula S. Azevedo Tags: Original Article Source Type: research

Colchicine for Secondary Prevention of Coronary Artery Disease: A Meta-Analysis of Randomised Controlled Trials
Colchicine has become prominent as an anti-inflammatory therapy for secondary cardiovascular prevention in patients with coronary artery disease (CAD). This meta-analysis was performed to evaluate the efficacy and safety of colchicine in patients with CAD. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 12, 2022 Category: Cardiology Authors: Haiyan Xu, Ling Mao, Hailang Liu, Zhenyu Lin, Yuanyuan Zhang, Jing Yang Tags: Original Article Source Type: research

Sex-Specific Outcomes Following Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Left Main Disease: A Systematic Review and Meta-Analysis
To assess whether outcomes following percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for left main coronary artery (LMCA) disease differ between men and women. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 12, 2022 Category: Cardiology Authors: Jennifer Y. Zhou, Emilia Nan Tie, Danny Liew, Stephen J. Duffy, James Shaw, Antony Walton, William Chan, Dion Stub Tags: Original Article Source Type: research

Letter to the Editor: Acute Coronary Syndrome Trends and COVID-19 Waves (Response to the Letter of Čulić et al.)
We would like to thank Professor C ̌ulić and colleagues for their interest in our paper [1] and for their comments [2]. We agree that multiple factors contributed to both a reduction in acute coronary syndrome (ACS) presentations during the first and second waves of the COVID-19 pandemic in Melbourne, as well as for the rebound in presentations when restrictions were eased. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 12, 2022 Category: Cardiology Authors: Nigel Sutherland, Nalin Dayawansa, Benjamin Filipopoulos, Sheran Vasanthakumar, Om Narayan, Francis A. Ponnuthurai, William van Gaal Tags: Letter to the Editor Source Type: research

Heart Foundation
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 11, 2022 Category: Cardiology Source Type: research

Cardiac Society of Australia and New Zealand
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 11, 2022 Category: Cardiology Source Type: research

Editorial Board
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 11, 2022 Category: Cardiology Source Type: research

Atrial Fibrillation Clinics: The Way of the Future
In this edition of Heart, Lung and Circulation, Al-Busaidi et  al. [1] present the long-term outcomes of patients managed through their atrial fibrillation (AF) clinical pathway with early review at an outpatient AF clinic following discharge from the emergency department. The pathway was aimed at reducing unnecessary hospital admissions and improving adheren ce to guideline-based AF treatment. AF is the most common sustained arrhythmia and is associated with increased risk of cardiovascular morbidity, stroke, dementia, and death [2]. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 11, 2022 Category: Cardiology Authors: Juliana Kanawati, Saurabh Kumar Tags: Editorial Source Type: research

Letter to the Editor Regarding: Acute Coronary Syndrome in the COVID-19 Pandemic: Reduced Cases and Increased Ischaemic Time by Sutherland et  al. Heart Lung Circ. 2022;31(1):69-76
Sutherland and colleagues recently reported a reduction in patients admitted with acute coronary syndrome (ACS) and an increase in total ischaemic time during the first and second wave of the COVID-19 outbreak in Melbourne [1]. They also observed a 20% rebound increase in ACS presentations following the relaxation of public health restrictions in November –December 2020 compared to the same period of 2019 and suggested that this could represent long-term sequelae of untreated ACS including reinfarction and heart failure. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 11, 2022 Category: Cardiology Authors: Viktor Čulić, Ahmed AlTurki, Riccardo Proietti Tags: Letter to the Editor Source Type: research

Impact of Pre-Hospital Activation of STEMI on False Positive Activation Rate and Door to Balloon Time
Pre-hospital identification of ST-segment elevation myocardial infarction (STEMI) by paramedical staff reduces reperfusion time. However, the impact of this approach on the rate of unnecessary activation of coronary catheterisation lab (CCL) remains unclear. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 15, 2021 Category: Cardiology Authors: Muhammad Shoaib, Wade Huish, Elizabeth L. Woollard, Jay Aguila, Dean Coxall, Mikhail Alexander, David Hicks, Brendan McQuillan Tags: Original Article Source Type: research

Long-Term Echocardiographic Follow-Up After Transcatheter Aortic Valve Implantation to Assess Structural Valve Deterioration and Bioprosthetic Valve Failure
Indications for transcatheter aortic valve implantation (TAVI) in aortic stenosis are expanding and the life expectancy of patients following TAVI is increasing. Determining the long-term durability of TAVI valves is therefore important. Rates of long-term ( ≥5 years) structural valve deterioration (SVD) vary widely and there are currently no comparable data from Australia. The aim herein was to determine the incidence of haemodynamic SVD and bioprosthetic valve failure (BVF) using recently standardised definitions in a Western Australian cohort after at least 5 years. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 13, 2021 Category: Cardiology Authors: Lauren Giudicatti, David Chieng, Kim Ireland, Graham Hillis, Frank M. Sanfilippo, Gerald Yong Tags: Original Article Source Type: research

Surgical Management for Traumatic Septal Rupture in a Child With Cardiogenic Shock
A 12-year-old boy had a blunt chest trauma in a motor vehicle accident. He arrested on arrival to the hospital and underwent clamshell thoracotomy for bilateral haemothorax. He required direct cardiac massage and massive transfusion for chest wall bleeding and pulmonary haemorrhage. Computerised tomography revealed a large apical ventricular septal defect (VSD) (Figure 1A). He developed cardiogenic shock with blood pressure 65/50 mmHg, central venous pressure 15 mmHg and lactate of 24 mmol/L, despite adrenaline/noradrenaline at 1.5 mcg/kg/min and vasopressin at 0.06 units/kg/hr. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 13, 2021 Category: Cardiology Authors: Antonia Schulz, Anika Rath, Siva P. Namachivayam, Igor E. Konstantinov Tags: Image Source Type: research

Renal Artery Partial Occlusion After Aortic Dissection Is Associated With Impaired Renal Function in the Affected Kidney
This study aimed to analyse the relationship between renal artery involvement and renal function. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 11, 2021 Category: Cardiology Authors: Hao Xu, Lu Dai, Wen-jian Jiang, Yang Liu, Guang-Rui Liu, Hai-Yang Li, Lian-Jun Huang, Feng Lan, Hong-Jia Zhang Tags: Original Article Source Type: research

Factor Xa Inhibition for the Treatment of Venous Thromboembolism Associated With Cancer: A Meta-Analysis of the Randomised Controlled Trials
Venous thromboembolism (VTE) is a common cause of morbidity and mortality in cancer patients. Until recently, guidelines recommended the use of low-molecular weight heparin (LMWH) as standard of care for VTE in patients with cancer. Despite the proven efficacy of direct oral anticoagulants (DOACs) for treatment of VTE, there is equipoise supporting their use in cancer patients. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 9, 2021 Category: Cardiology Authors: Alexandra C. Murphy, Anoop N. Koshy, Omar Farouque, Belinda Yeo, Jaishankar Raman, Leighton Kearney, Matias B. Yudi Tags: Original Article Source Type: research

Proximal Aortic Graft Infection: Time for Treatment in an Aortic Centre?
In this issue of Heart, Lung and Circulation, Chong et  al. [1] review and summarise the current management and outcomes of proximal aortic graft infection (PAGI). Their systematic review included 20 studies representing 290 PAGI patients who underwent reoperation or treatment with antibiotics alone (25 patients); they concluded that prompt referral to specialised aortic centres is recommended, to plan for best management strategies and improve patient outcomes [1]. This editorial aims to shed light on some critical aspects of managing this infrequent and challenging surgical problem, and to discuss the complexities o...
Source: Heart, Lung and Circulation - December 7, 2021 Category: Cardiology Authors: Adam El-Gamel Tags: Editorial Source Type: research

Editorial Board
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 7, 2021 Category: Cardiology Source Type: research

Cardiac Society of Australia and New Zealand
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 7, 2021 Category: Cardiology Source Type: research

Heart Foundation
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 7, 2021 Category: Cardiology Source Type: research

Endoscopic Mitral Valve Repair in a Patient With Persistent Left Superior Vena Cava Draining Into the Coronary Sinus – Cannulation Technique and Surgical Management
Persistence of the left superior vena cava is often an incidental finding during cardiac surgical procedures. In minimally invasive valvular surgery, it may jeopardise venous drainage and myocardial protection. This How-To-Do-It paper describes the cannulation strategy in a case of minimally invasive mitral surgery in a patient with persistence of the left superior vena cava and absence of the anonymous vein detected with preoperative multimodality imaging. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - December 7, 2021 Category: Cardiology Authors: Giacomo Bianchi, Giovanni Concistr è, Dorela Haxhiademi, Beatrice Caliani, Michele Guarino, Marco Solinas Tags: How-To-Do-It Source Type: research

Chronic Rejection and Atherosclerosis in Post-Transplant Cardiovascular Mortality: Two Sides of the Same Coin
Cardiovascular disease (CVD) as defined by the American Heart Association includes ischaemic heart disease, stroke, heart failure and thromboembolism [1]. Solid organ transplantation is associated with an increased risk of CVD morbidity and mortality [2], a relationship which was first observed in the context of kidney transplantation by Foley in 1998 [3]. This manifests clinically as an increased rate of major adverse cardiovascular events (MACE), defined as the composite of cardiac death, non-fatal myocardial infarction, non-fatal stroke, unstable angina and heart failure [4,5]. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 27, 2021 Category: Cardiology Authors: Afolarin A. Otunla, Kumaran Shanmugarajah, Maria Lucia Madariaga, Alun H. Davies, Joseph Shalhoub Tags: Editorial Source Type: research

Current Clinical Practice in Patients With Cardiac Implantable Electronic Devices (CIED) Undergoing Radiotherapy (RT)
Patients with cardiac implantable electronic devices (CIED) undergoing radiotherapy (RT) are more common due to ageing of the population. With newer CIEDs implementing the complementary metal-oxide semiconductor (CMOS) technology which allows the miniaturisation of CIED, it is also more susceptible to RT. Effects of RT on CIED ranges from device interference, device operational/memory errors of permanent damage. These malfunctions can cause life threatening clinical effects. Cumulative dose is not the only component of RT that causes CIED malfunction, as neutron use and dose rate effect also affects CIEDs. (Source: Heart, ...
Source: Heart, Lung and Circulation - November 26, 2021 Category: Cardiology Authors: Meor Azraai, Daniel D'Souza, Voltaire Nadurata Tags: Review Source Type: research

Inter-Ethnic Differences in Valvular Dysfunction, Aortopathy, and Progression of Disease of an Asian Bicuspid Aortic Valve Population
There are differences in bicuspid aortic valve (BAV) characteristics between Asian and European populations, but little is known about the inter-ethnic differences in bicuspid valve function and aortic root dimensions within the diverse Asian population. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 26, 2021 Category: Cardiology Authors: Nicholas W.S. Chew, Kailun Phua, Jinghao Nicholas Ngiam, Clare Cheong, Gwyneth Kong, Julia L.M. Ng, Ching-Hui Sia, Poay-Huan Loh, Chi-Hang Lee, Raymond C.C. Wong, Kian-Keong Poh, Tiong-Cheng Yeo, William K.F. Kong Tags: Original Article Source Type: research

The Spectrum, Severity and Outcomes of Rheumatic Mitral Valve Disease in Pregnant Women in Australia and New Zealand
Rheumatic heart disease (RHD) poses significant perinatal risks. We aimed to describe the spectrum, severity and outcomes of rheumatic mitral valve disease in pregnancy in Australia and New Zealand. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 25, 2021 Category: Cardiology Authors: Marc G.W. R émond, Zhuoyang Li, Geraldine Vaughan, Jane Frawley, Michael J. Peek, Jonathan R. Carapetis, Bo Remenyi, William Parsonage, Claire McLintock, Elizabeth A. Sullivan Tags: Original Article Source Type: research

Prognostic Implication of Direct Cardiac Invasion from Lung Cancer in Non-Operatively Treated Patients Based on Lung Computed Tomography Imaging
Lung cancer with direct cardiac invasion (LCCI+) exerts a significant influence on the survival of patients. There is a paucity of comparative research into the prognosis of advanced lung cancer with and without direct cardiac invasion. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 25, 2021 Category: Cardiology Authors: Ying Zhong, Ce Li, Yuehuan Sheng, Jiaqi Wang, Guan Wang Tags: Original Article Source Type: research

Ventricular Double Rupture: A Rare Combination of Ventricular Septal Rupture and Concealed Post-Infarction Free Wall Rupture
A 72-year-old woman with well-controlled hypertension presented to our hospital due to worsening symptoms of heart failure. She had a history of acute anterior wall ST-elevation myocardial infarction (MI) diagnosed 2 weeks previously, when she received clinically successful fibrinolytic therapy at another regional hospital 4 hours after symptom onset. Four (4) days after hospital discharge, she gradually developed dyspnoea on exertion and orthopnoea. No recurrent chest pain was reported. On examination, her blood pressure was 120/65 mmHg with a regular pulse rate at 90/minute. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 25, 2021 Category: Cardiology Authors: Nonthikorn Theerasuwipakorn, Prapaporn Khemngern, Wasinee Promratpan, Pairoj Chattranukulchai Tags: Image Source Type: research

The Functions of LncRNA H19 in the Heart
Cardiovascular diseases (CVDs) are major causes of morbidity and mortality worldwide. Great effort has been put into exploring early diagnostic biomarkers and innovative therapeutic strategies for preventing CVD progression over the last two decades. Long non-coding RNAs (lncRNAs) have been identified as novel regulators in cardiac development and cardiac pathogenesis. For example, lncRNA H19 (H19), also known as a fetal gene abundant in adult heart and skeletal muscles and evolutionarily conserved in humans and mice, has a regulatory role in aortic aneurysm, myocardial hypertrophy, extracellular matrix reconstitution, and...
Source: Heart, Lung and Circulation - November 25, 2021 Category: Cardiology Authors: Yao Wang, Xiaojing Sun, Xianglan Sun Tags: Review Source Type: research

Balloon Pulmonary Angioplasty in Patients With Inoperable or Recurrent/Residual Chronic Thromboembolic Pulmonary Hypertension: A Single-Centre Initial Experience
This study aimed to report the initial experience of BPA in a tertiary referral centre for CTEPH. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 24, 2021 Category: Cardiology Authors: Halil Atas, Bulent Mutlu, Dursun Akaslan, Derya Kocakaya, Batur Kanar, Nevsun Inanc, Sait Karakurt, Cagatay Cimsit, Bedrettin Yildizeli Tags: Original Article Source Type: research

Mitral Valve Regurgitation After Lung Transplantation: Aetiology, Management and Outcome
Problematic mitral regurgitation (MR) may develop following lung transplantation (LTx). There is limited information on the management of MR in LTx patients, as such we sought to evaluate our centre ’s experience. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 24, 2021 Category: Cardiology Authors: William Y. Shi, Jason E. Bloom, Rong Shen, Bronwyn J. Levvey, Antony S. Walton, Silvana F. Marasco, Adam Zimmet, Gregory Snell, David C. McGiffin Tags: Original Article Source Type: research

Time to Reconsider the Diagnosis of “Left Ventricular Noncompaction” in Adults?
Left ventricular non-compaction (LVNC) is characterised by a bi-layered myocardium, with excessive left ventricular (LV) trabeculation. Ongoing debate exists as to whether LVNC in adults is a distinct cardiomyopathy, or a morphological feature of ventricular remodelling present in physiological and pathological states. In this commentary, we explore how an increase in the diagnosis amongst the healthy adult population, in addition to cardiovascular cohorts and athletes [1], has led to likely overdiagnosis or misdiagnosis —whereby a diagnosis leads to more harm than benefit. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 24, 2021 Category: Cardiology Authors: Samantha Barratt Ross, Alexandra Barratt, Christopher Semsarian Tags: Editorial Source Type: research

Iron Deficiency in Heart Failure Patients and Benefits of Iron Replacement on Clinical Outcomes Including Comorbid Depression
Iron deficiency and depression are prevalent comorbidities in the setting of heart failure. Both conditions are associated with poorer patient outcomes including mortality, hospitalisation and quality of life. Iron replacement has come to the fore as a means to improve patient outcomes. This review aims to assess the current literature regarding the benefits of iron supplementation for iron deficient heart failure patients including potential improvements in depression. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 19, 2021 Category: Cardiology Authors: Kevin W. Huang, Nazar L. Bilgrami, David L. Hare Tags: Review Source Type: research

Intrathoracic Migration of a Loop Recorder Device: An Unusual Clinical Entity
Intrathoracic migration of devices implanted into the chest  wall causing major intrathoracic injuries has been documented [1-3]. To our knowledge, there have been no reports on intrathoracic migration of an implanted loop recorder. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 15, 2021 Category: Cardiology Authors: Ang Nicholas, Ng Kevin, Saxena Pankaj Tags: Image Source Type: research

Polycythaemia Vera and Coronary Artery Bypass Graft Surgery: A Systematic Review of the Literature
Polycythaemia vera (PV) is a condition that may potentially put patients undergoing cardiac surgery at an increased risk of bleeding and thrombosis; however, there is currently a paucity of literature regarding the management of these patients. We aim to examine the literature in this systematic review to indicate the interventions that may be considered to minimise complications. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 15, 2021 Category: Cardiology Authors: Imran Karim Janmohamed, Rajan Singh Sondh, Hasan Ahmed, Muhammad Bilal Afzal, Nathan Tyson, Amer Harky Tags: Review Source Type: research

Factors Influencing Cardiac Sympathetic Nervous Function in Patients With Severe Aortic Stenosis: Assessment by 123I-Metaiodobenzylguanidine Myocardial Scintigraphy
Numerous studies have shown that 123I-metaiodobenzylguanidine (MIBG) scintigraphy, an index of cardiac sympathetic nervous (CSN) activity, is useful for predicting prognosis in patients with heart failure. However, the factors influencing the CSN activity of patients with severe aortic stenosis (AS) remain unclear. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 15, 2021 Category: Cardiology Authors: Kazuhiro Nitta, Yukihiro Fukuda, Kosuke Takahari, Atsushi Takeda, Tasuku Higashihara, Yuichi Morita, Noriaki Watanabe, Hiroki Ikenaga, Hiroto Utsunomiya, Ken Ishibashi, Satoshi Kurisu, Shinya Takahashi, Kazuo Awai, Yukiko Nakano Tags: Original Article Source Type: research

New Minimally Invasive and Tailor-Made Strategy for Cryoballoon Ablation in Patients With Paroxysmal Atrial Fibrillation
The optimal dosage for cryoballoon ablation (CBA) of atrial fibrillation (AF) is still unknown. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 6, 2021 Category: Cardiology Authors: Takayuki Nakano, Kazuyoshi Suenari, Akira Okada, Yohei Hyodo, Shunsuke Tomomori, Tadanao Higaki, Kuniomi Oi, Kazuoki Dai, Tomoharu Kawase, Yasuharu Nakama, Kenji Nishioka, Masaya Otsuka, Yoshiko Masaoka, Nobuo Shiode, Yukiko Nakano Tags: Original Article Source Type: research

Accuracy of 18F-FDG in Detecting Stage I Lung Adenocarcinomas According to IASLC/ATS/ERS Classification
Only a small number of studies have explored the clinicopathological features of pulmonary adenocarcinoma (PA) associated with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) false-negative (FN) results. Herein, we investigated the FDG-PET diagnostic performance by stratifying PAs according to International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 6, 2021 Category: Cardiology Authors: Filippo Lococo, Francesco Guerrera, Ottavio Rena, Luca Ampollini, Jacopo Vannucci, Pietro Bertoglio, Luigi Ventura, Paraskevas Lyberis, Valentina Marchese, Vincenzo Arena, Pier Luigi Filosso, Adriana Lesca, Caterina Casadio, Andrea Viti, Massimiliano Paci Tags: Original Article Source Type: research

Editorial Board
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 4, 2021 Category: Cardiology Source Type: research

Heart Foundation
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 4, 2021 Category: Cardiology Source Type: research

Cardiac Society of Australia and New Zealand
(Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 4, 2021 Category: Cardiology Source Type: research

Heart, Lung and Circulation in the COVID-19 Era: About COVID-19, Not Just About COVID-19
In March 2020, our world entered the COVID-19 era [1], and we have all since been experiencing waves of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic [2]. The effect of COVID-19 on our populations and health care systems has been, and continues to be, significant. The global pandemic has also affected scientific medical publishing, with an acknowledged disrupting effect, including a faster track to peer review and on-line publication for COVID-19 submissions but with stress on the peer review and publication of non-COVID-19 research [3]. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 4, 2021 Category: Cardiology Authors: Ann T. Gregory, A. Robert Denniss Tags: Editorial Source Type: research

Characteristics and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction Compared to Heart Failure With Reduced Ejection Fraction: Insights From the VCOR Heart Failure Snapshot
Heart failure is increasing in prevalence, creating a greater public health and economic burden on our health care system. With a rising proportion of hospitalisations for heart failure with preserved ejection fraction (HFpEF) compared to heart failure with reduced ejection fraction (HFrEF) and lack of proven therapies for HFpEF, patient characterisation and defining clinical outcomes are important in determining optimal management of heart failure patients. There is scarce Australian-specific data with regards to the burden of disease of patients with HFpEF which further limits our ability to appropriately manage this syn...
Source: Heart, Lung and Circulation - November 3, 2021 Category: Cardiology Authors: Christianne Tan, Diem Dinh, Angela Brennan, David L. Hare, David Kaye, Jeffrey Lefkovits, Siobhan Lockwood, Christopher Neil, David Prior, Arthur Nasis, Andrew Wilson, Christopher M. Reid, Dion Stub, Andrea Driscoll Tags: Original Article Source Type: research

Type of Stressor and Medium-Term Outcomes After Takotsubo Syndrome: What Becomes of the Broken Hearted? (ANZACS-QI 59)
Takotsubo syndrome (TS) is often triggered by an acute physical or emotional stressor. We hypothesised that medium-term prognosis may be better for TS patients with an associated emotional stressor than for those with an acute physical illness. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 3, 2021 Category: Cardiology Authors: Jen-Li Looi, Toby Verryt, Peter McLeod, Christina Chan, James Pemberton, Mark Webster, Andrew To, Mildred Lee, Andrew J. Kerr Tags: Original Article Source Type: research

Letter to the Editor Regarding “Pulmonary Embolism Prophylaxis in Patients With COVID-19: an Emerging Issue”, Heart Lung Circ. 2021;30(10):1435–41.
I read the article by Sanidas and colleagues [1] with great interest and congratulate the authors on their excellent work. However, I would like to draw attention to several points. Recent findings suggest that SARS-CoV-2 controls the expression of host regulatory molecules such as miRNAs and transcription factors (TFs), often regulating gene expression at transcriptional and post-transcriptional levels and forming highly complex network interactions [2]. Research has identified four miRNAs (hsa-mir-9-5p, hsa-mir-324-3p, hsa-mir-1827, and hsa-mir-1277-5p) and TFs (EP300, MYC, E2F1, and SP1) that co-regulate important targe...
Source: Heart, Lung and Circulation - November 3, 2021 Category: Cardiology Authors: Salvatore Patan è Tags: Letter to the Editor Source Type: research

Management of Acute Decompensated Heart Failure in Rural Versus Metropolitan Settings: An Australian Experience
Acute decompensated heart failure (ADHF) is the most common cause of hospital admission in patients over 65, with poorer outcomes demonstrated in rural versus metropolitan areas. The aim of this study was to compare the in-hospital and post-discharge management of ADHF patients admitted to rural versus metropolitan hospitals in Victoria. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 2, 2021 Category: Cardiology Authors: R. Kimberley Chan, Diem T. Dinh, David L. Hare, Siobhan Lockwood, Chris Neil, David Prior, Angela Brennan, Jeffrey Lefkovits, Harriet Carruthers, Christopher M. Reid, Andrea Driscoll, the VCOR-HF Investigators Tags: Original Article Source Type: research

Engaging Patients in Lifestyle Behaviour Change in Cardiovascular Secondary Prevention: Understanding the Complexity
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Though total mortality rates for coronary artery disease have decreased significantly in the last three decades where there is access to modern therapeutics, at the same time, multiple risk factors such as obesity, diabetes mellitus and depression and anxiety have increased substantially [1]. Cardiovascular prevention and rehabilitation are therefore paramount and should be offered to all clinically eligible patients with CVD. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 2, 2021 Category: Cardiology Authors: Carolyn M. Astley, Julie Redfern, Susie H. Cartledge, Tom Briffa Tags: Editorial Source Type: research

Relationship of Myocardial Gadolinium Enhancement to Late Clinical Outcomes: Implications for the COVID-19 era
In April 2021, coronavirus (COVID-19) surpassed 130 million cases and accounted for three million deaths, globally [1]. A recent study established one-third of individuals, 2 months post-recovery from COVID-19 with low normal left ventricular ejection fraction (LVEF), exhibited myocardial late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) [2]. To advance understanding regarding implications for prognosis of such findings [2,3], we report late outcomes associated with LGE and preserved LVEF amongst an historical Australian cohort i.e., before the current COVID-19 era. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 1, 2021 Category: Cardiology Authors: Paraskevi Morris, Sean Lal, Shisan Bao, Mark Dennis, Imre Hunyor, John O ’Sullivan, Stuart M. Grieve, Rajesh Puranik Tags: Letter to the Editor Source Type: research

The Australian National Standards of Care for Childhood-Onset Heart Disease (CoHD)
We wanted to bring to the notice of the readership an important, Commonwealth funded initiative to embed excellence in comprehensive care for all Australian patients (both children and adults) and families whose health journey has involved heart disease with onset in childhood, both congenital or acquired. This will secure, but also augment, the already high levels of care available to patients in Australia. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 1, 2021 Category: Cardiology Authors: Gary Sholler, Lisa Selbie Tags: Letter to the Editor Source Type: research

Surveillance of End-Organ Damage in Fontan Patients Prior to Transition to Adult Care: Are We There Yet?
Recently published guidelines and consensus statements have outlined recommended screening practices for monitoring of end-organ dysfunction in Fontan patients. We reviewed the current approach to end-organ screening in a local population of Fontan patients at the time of transition to adult care. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - October 28, 2021 Category: Cardiology Authors: Thomas G. Wilson, Ajay J. Iyengar, Dominica Zentner, Yves d ’Udekem Tags: Original Article Source Type: research

Neurological Complications in COVID-19 Patients With ECMO Support: A Systematic Review and Meta-Analysis
Patients with Coronavirus disease 2019 (COVID-19)-related acute respiratory disease (ARDS) increasingly receive extracorporeal membrane oxygenation (ECMO) support. While ECMO has been shown to increase risk of stroke, few studies have examined this association in COVID-19 patients. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - October 28, 2021 Category: Cardiology Authors: Nivedha V. Kannapadi, Meghana Jami, Lavienraj Premraj, Eric W. Etchill, Katherine Giuliano, Errol L. Bush, Bo Soo Kim, Stella Seal, Glenn Whitman, Sung-Min Cho Tags: Original Article Source Type: research