Genes, Vol. 15, Pages 577: Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes
ynski
P53 overexpression plays a critical role in cancer pathogenesis by disrupting the intricate regulation of cellular proliferation. Despite its firmly established function as a tumor suppressor, elevated p53 levels can paradoxically contribute to tumorigenesis, influenced by factors such as exposure to carcinogens, genetic mutations, and viral infections. This phenomenon is observed across a spectrum of cancer types, including bladder (BLCA), ovarian (OV), cervical (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), head and neck squamou...
Source: Genes - April 30, 2024 Category: Genetics & Stem Cells Authors: Ruby Khan Bakht Pari Krzysztof Puszynski Tags: Article Source Type: research
Molecules, Vol. 29, Pages 2077: Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management
rigoswami
Cancer is one of the major causes of death, and its negative impact continues to rise globally. Chemotherapy, which is the most common therapy, has several limitations due to its tremendous side effects. Therefore, developing an alternate therapeutic agent with high biocompatibility is indeed needed. The anti-oxidative effects and bioactivities of several different crude extracts of marine algae have been evaluated both in vitro and in vivo. In the present study, we synthesized the aqueous extract (HA) from the marine algae Amphiroa anceps, and then, a liposome was formulated for that extract (NHA). The extra...
Source: Molecules - April 30, 2024 Category: Chemistry Authors: Gopalarethinam Janani Agnishwar Girigoswami Balasubramanian Deepika Saranya Udayakumar Koyeli Girigoswami Tags: Article Source Type: research
Viruses, Vol. 16, Pages 718: Nirmatrelvir Resistance in an Immunocompromised Patient with Persistent Coronavirus Disease 2019
We present a patient who independently acquired a T21I mutation in the 3CL protease after nirmatrelvir exposure. The T21I mutation in the 3CL protease is one of the most frequent mutations responsible for nirmatrelvir resistance. However, limited reports exist on actual cases of SARS-CoV-2 with T21I and other mutations in the 3CL protease. The patient, a 55 year-old male, had COVID-19 during chemotherapy for multiple myeloma. He was treated with nirmatrelvir early in the course of the disease but relapsed, and SARS-CoV-2 with a T21I mutation in the 3CL protease was detected in nasopharyngeal swab fluid. The patient had tem...
Source: Viruses - April 30, 2024 Category: Virology Authors: Chie Yamamoto Masashi Taniguchi Keitaro Furukawa Toru Inaba Yui Niiyama Daisuke Ide Shinsuke Mizutani Junya Kuroda Yoko Tanino Keisuke Nishioka Yohei Watanabe Koichi Takayama Takaaki Nakaya Yoko Nukui Tags: Brief Report Source Type: research
Cancers, Vol. 16, Pages 1754: Antiretroviral Drug Repositioning for Glioblastoma
rine DeMarino
John D. Heiss
Avindra Nath
Ashish H. Shah
Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches. Drug repositioning studies on antiretroviral therapy (ART) have shown promising potent antineoplastic effects in multiple cancers; however, its efficacy in GBM remains unclear. To better understand the pleiotropic anticancer effects of ART on GBM, we conducted a comprehensive drug repurposing ana...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Sarah R. Rivas Mynor J. Mendez Valdez Jay S. Chandar Jelisah F. Desgraves Victor M. Lu Leo Ampie Eric B. Singh Deepa Seetharam Christian K. Ramsoomair Anna Hudson Shreya M. Ingle Vaidya Govindarajan Tara T. Doucet-O ’Hare Catherine DeMarino John D. Heis Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1747: Recent Progress in Treatment for HER2-Positive Advanced Gastric Cancer
aki
Human epidermal receptor (HER) 2-positive advanced gastric cancer is one of the major subtypes of gastric cancer, accounting for ~20% of all cases. Although combination therapy with trastuzumab and chemotherapy provides meaningful survival benefit, clinical trials targeting HER2 have failed to demonstrate clinical benefits in first- or subsequent-line treatment. Trastuzumab deruxtecan, an antibody–drug conjugate, has shown positive results even in later-line treatment and has become new standard treatment. In first-line therapy, combination therapy with pembrolizumab and trastuzumab plus chemotherapy ...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Takeshi Kawakami Kentaro Yamazaki Tags: Review Source Type: research
A plain language summary of the TROPHY-U-01 study: sacituzumab govitecan use in people with locally advanced or metastatic urothelial cancer
CONCLUSIONS REPORTED BY THE RESEARCHERS?: The study showed that sacituzumab govitecan had significant anti-cancer activity. Though most participants who received sacituzumab govitecan experienced side effects, these did not usually stop participants from continuing sacituzumab govitecan. Doctors can help control these side effects using treatment guidelines, but these side effects can be serious. Clinical Trial Registration: NCT03547973 (ClinicalTrials.gov) (TROPHY-U-1).PMID:38682560 | DOI:10.2217/fon-2023-1030 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Yohann Loriot Arash Rezazadeh Kalebasty Aude Fl échon Rohit K Jain Sumati Gupta Manojkumar Bupathi Philippe Beuzeboc Phillip Palmbos Arjun V Balar Christos E Kyriakopoulos Damien Pouessel Cora N Sternberg Julia Tonelli Mitch Sierecki Huafeng Zhou Petros Source Type: research
Evaluation of the Combined Effect of Caffeine and 5-Fluorouracil on Colorectal Cancer Cell Lines
In this study, initially HCT116 and HEK293 cell lines were cultured as cancer and normal cells, respectively. These cell lines were then evaluated for cytotoxicity, induction of apoptosis, and rate of cell migration. All data were analyzed by statistical methods.RESULTS: The results indicated that a combination of caffeine and 5-FU augmented their cytotoxicity in HCT116 cells but reduced cytotoxicity in HEK293 cells. No reduction was observed in the migration of HCT116 cells that were treated with caffeine or a combination of caffeine and 5-FU. Also, it seems that caffeine reverses the apoptotic effect of 5-FU in HCT116 ce...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Fatemeh Khavari Mohammad Taheri Hamed Manoochehri Pejman Molaei Fatemeh Nouri Source Type: research
The Impact of Tumor Hypoxia Modulation on sIL-2R Levels in Newly Diagnosed Diffuse Large B Cell Lymphoma (DLBCL) Patients Undergoing Chemotherapy: A Randomized Clinical Trial
CONCLUSION: Tumor hypoxia modulation led to a significant decrease in serum sIL-2R levels, potentially through improvements in the crosstalk between hypoxia and inflammation pathways.PMID:38679992 | DOI:10.31557/APJCP.2024.25.4.1315 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Daniel Rizky Kevin Tandarto Eko Adhi Pangarsa Ridho M Naibaho Sigit P Kurniawan Damai Santosa Budi Setiawan Catharina Suharti Source Type: research
Investigations of Ni(II)Cysteine-Tyrosine Dithiocarbamate Complex: Synthesis, Characterization, Molecular Docking, Molecular Dynamic, and Anticancer Activity on MCF-7 Breast Cancer Cell Line
CONCLUSION: there were 5 residues responsible for maintaining the ligand binding stable. The compound had significant Hbond contact intensity, however, it was not strong enough to make a significant anticancer effect. Though the synthesized compound shows low bioactivity, this research is expected to give valuable insight into the effect of molecular structure on anticancer activity.PMID:38679991 | DOI:10.31557/APJCP.2024.25.4.1301 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Eka Pratiwi Indah Raya Hasnah Natsir Rizal Irfandi Paulina Taba Rugaiyah Arfah Herlina Rasyid Yusafir Hala Syahruddin Kasim Andi Besse Khaerunnisa Baso Ilham Maulida Mazaya Yosua Tanzil Dewi Luthfiana Source Type: research
Outcomes of Induction Chemotherapy Followed by Chemoradiotherapy Versus Chemoradiotherapy Alone in Esophageal Squamous Cell Carcinoma Induction chemotherapy in Esophageal Squamous Cell Carcinoma
CONCLUSION: Our data demonstrated that a combination of IC and CRT might be a promising treatment strategy to further improve OS in ESCC patients.PMID:38679976 | DOI:10.31557/APJCP.2024.25.4.1183 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Saeed Hosseini Toudeshki Maryam Garousi Amir Mohammad Arefpour Pedram Fadavi Ali Basi Ahmad Foroughi Seyed Alireza Javadinia Source Type: research
Anxiety Levels in Brazilian Women with Metastatic Breast Cancer Undergoing Palliative Chemotherapy: A Prospective Study
CONCLUSION: Women with breast cancer undergoing palliative chemotherapy exhibited high trait-anxiety scores, which decreased significantly over the course of treatment.PMID:38679972 | DOI:10.31557/APJCP.2024.25.4.1135 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Larissa Marcondes Leonel Dos Santos Silva Cristiano De Oliveira Ribeiro Natalia Naome Oshiro Luciana De Alcantara Nogueira Paulo Ricardo Bittencourt Guimaraes Luciana Puchalski Kalinke Source Type: research
Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
Expandable endoprostheses in skeletally immature patients: Where we are
World J Orthop. 2024 Apr 18;15(4):312-317. doi: 10.5312/wjo.v15.i4.312. eCollection 2024 Apr 18.ABSTRACTApproximately 45 percent of malignant bone tumors are seen under the age of 16 and one of the important results of growth plate sacrification in patients with immature skeletons is limb inequality. Until the early 1990s, the treatment options for these patients were rotationplasty or amputation. Multimodal approaches that combine imaging, chemotherapy, and surgical techniques have enabled the development of limb-preserving methods with satisfactory results. In order to overcome inequality problems, expandable prostheses ...
Source: World Journal of Orthopaedics - April 29, 2024 Category: Orthopaedics Authors: Recep Öztürk Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
