Cancers, Vol. 16, Pages 1754: Antiretroviral Drug Repositioning for Glioblastoma

Cancers, Vol. 16, Pages 1754: Antiretroviral Drug Repositioning for Glioblastoma Cancers doi: 10.3390/cancers16091754 Authors: Sarah R. Rivas Mynor J. Mendez Valdez Jay S. Chandar Jelisah F. Desgraves Victor M. Lu Leo Ampie Eric B. Singh Deepa Seetharam Christian K. Ramsoomair Anna Hudson Shreya M. Ingle Vaidya Govindarajan Tara T. Doucet-O’Hare Catherine DeMarino John D. Heiss Avindra Nath Ashish H. Shah Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches. Drug repositioning studies on antiretroviral therapy (ART) have shown promising potent antineoplastic effects in multiple cancers; however, its efficacy in GBM remains unclear. To better understand the pleiotropic anticancer effects of ART on GBM, we conducted a comprehensive drug repurposing analysis of ART in GBM to highlight its utility in translational neuro-oncology. To uncover the anticancer role of ART in GBM, we conducted a comprehensive bioinformatic and in vitro screen of antiretrovirals against glioblastoma. Using the DepMap repository and reversal of gene expression score, we conducted an unbiased screen of 16 antiretrovirals in 40 glioma cell lines to identify promising candidates for GBM drug repositioning. We utilized patient-derived neurospheres and glioma...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research