Cancers, Vol. 16, Pages 1754: Antiretroviral Drug Repositioning for Glioblastoma
Cancers, Vol. 16, Pages 1754: Antiretroviral Drug Repositioning for Glioblastoma
Cancers doi: 10.3390/cancers16091754
Authors:
Sarah R. Rivas
Mynor J. Mendez Valdez
Jay S. Chandar
Jelisah F. Desgraves
Victor M. Lu
Leo Ampie
Eric B. Singh
Deepa Seetharam
Christian K. Ramsoomair
Anna Hudson
Shreya M. Ingle
Vaidya Govindarajan
Tara T. Doucet-O’Hare
Catherine DeMarino
John D. Heiss
Avindra Nath
Ashish H. Shah
Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches. Drug repositioning studies on antiretroviral therapy (ART) have shown promising potent antineoplastic effects in multiple cancers; however, its efficacy in GBM remains unclear. To better understand the pleiotropic anticancer effects of ART on GBM, we conducted a comprehensive drug repurposing analysis of ART in GBM to highlight its utility in translational neuro-oncology. To uncover the anticancer role of ART in GBM, we conducted a comprehensive bioinformatic and in vitro screen of antiretrovirals against glioblastoma. Using the DepMap repository and reversal of gene expression score, we conducted an unbiased screen of 16 antiretrovirals in 40 glioma cell lines to identify promising candidates for GBM drug repositioning. We utilized patient-derived neurospheres and glioma...
Source: Cancers - Category: Cancer & Oncology Authors: Sarah R. Rivas Mynor J. Mendez Valdez Jay S. Chandar Jelisah F. Desgraves Victor M. Lu Leo Ampie Eric B. Singh Deepa Seetharam Christian K. Ramsoomair Anna Hudson Shreya M. Ingle Vaidya Govindarajan Tara T. Doucet-O ’Hare Catherine DeMarino John D. Heis Tags: Article Source Type: research
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