Spatial profiling of ovarian carcinoma and tumor microenvironment evolution under neoadjuvant chemotherapy

CONCLUSIONS: Several iTMEs exist during tumor evolution and NACT impact on iTME is heterogeneous. Clustering analysis of patients, unravels several IC subsets within OC and can guide future personalized approaches. Targeting different checkpoints such as TIM-3, LAG-3 and IDO-1, more prevalent than PD-L1, could more effectively harness anti-tumor immunity in this anti-PD-L1 resistant malignancy.PMID:38669064 | DOI:10.1158/1078-0432.CCR-23-3836

Source: Clinical Cancer Research - April 26, 2024 Category: Cancer & Oncology Authors: Elisa Yaniz-Galende Qinghe Zeng Juan Francisco Grau-Bejar Christophe Klein F élix Blanc-Durand Audrey Le Formal Eric Pujade-Lauraine Laure Chardin Elodie Edmond Virginie Marty Isabelle Ray-Coquard Florence Joly Gwena ël Ferron Patricia Pautier Dominique Source Type: research