Problematic Consumption of Alcohol, Cannabis and Cigarettes —a German Nationwide Survey on Psychopathology, Stress, Mindfulness, and Quality of Life
CONCLUSION: A comparison with the few available previous findings implies that problematic alcohol consumption has become more prevalent. There were both similarities and differences across the three substances studied with respect to patterns of problematic consumption, particularly in relation to the experience of stress.PMID:38657177 | DOI:10.3238/arztebl.m2024.0061 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 24, 2024 Category: General Medicine Authors: Lutz Wartberg Matthias Belau Nicolas Arnaud Rainer Thomasius the IMAC Mind Consortium Source Type: research
Alcohol consumption during pregnancy by women from southern Brazil: a cross-sectional study
CONCLUSIONS: Alcohol intake during pregnancy is common and affects nearly one-third of pregnant women. Knowledge of the population at risk and protective factors is essential for the development of campaigns that seek to reduce consumption and, therefore, its consequences for the mother and fetus.PMID:38655982 | DOI:10.1590/1516-3180.2023.0186.R1.08022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: Laira Francielle Ferreira Zottis Mateus Arenhardt de Souza J éssica Karine Hartmann Thiago Kenji Kurogi Gama La ís Borges Rizental Anita Machado Maciel Merialine Gresele Ernani Bohrer da Rosa Maur ício Rouvel Nunes Juliana Trevisan da Rocha Jorge Alber Source Type: research
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury
This study aimed to assess the effects of alirocumab, a monoclonal antibody targeting PCSK9 to lower systemic low-density lipoprotein cholesterol (LDL-C), on central nervous system (CNS) pathology in a rat model of chronic alcohol exposure. Alirocumab (50 mg/kg) or vehicle was administered weekly for six weeks in 32 male rats subjected to a 35 % ethanol liquid diet or a control liquid diet (n = 8 per group). The study evaluated PCSK9 expression, LDL receptor (LDLR) expression, oxidative stress, and neuroinflammatory markers in brain tissues. Chronic ethanol exposure increased PCSK9 expression in the brain, while alirocumab...
Source: Brain, Behavior, and Immunity - April 24, 2024 Category: Neurology Authors: Josephin Wagner Lauren M Park Partha Mukhopadhyay Csaba Matyas Eszter Trojnar Ruslan Damadzic Jeesun Jung Andrew S Bell Lucas A Mavromatis Ali M Hamandi Daniel B Rosoff Leandro F Vendruscolo George F Koob Pal Pacher Falk W Lohoff Source Type: research
Smoking cessation among tuberculosis patients during the coronavirus disease-2019 pandemic
In conclusion, TB smokers who tried to quit smoking during the COVID-19 pandemic faced many challenges. Despite this, we demonstrated a reasonable smoking cessation rate with a nurse-conducted motivational interview.PMID:38656469 | DOI:10.4081/monaldi.2024.2970 (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 24, 2024 Category: Respiratory Medicine Authors: Sandra Eug ênia Coutinho Raimunda Sinthia Lima de Braga Andr é Külzer Santos Joanna Scopel Velho Denise Rossato Silva Source Type: research
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
Int Immunopharmacol. 2024 Apr 23;133:112091. doi: 10.1016/j.intimp.2024.112091. Online ahead of print.ABSTRACTThe pathophysiology of hepatic steatosis is thoroughly reviewed in this comprehensive report, with particular attention to the complex interactions between inflammatory pathways, insulin resistance, lipid metabolism, metabolic dysregulation, and immunological responses in the liver including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). The study highlights the role of immune cell regulation in disease progression and explores the potential of i...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Arnab Banerjee Debasmita Das Sandip Mukherjee Bithin Kumar Maji Source Type: research
Blood Pressure Control and Associated Factors among Hypertension Comorbid Type 2 Diabetic Patients in Southeast Ethiopia
CONCLUSION: Uncontrolled hypertension was found to be high among hypertension comorbid type 2 diabetic patients. Patients' adherence to antihypertensive medication, physical activity, and alcohol abstinence should be maximized. Loss of weight is also crucial, as is the early detection and management of comorbidities.PMID:38655153 | PMC:PMC11039015 | DOI:10.1155/2024/6668436 (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - April 24, 2024 Category: Cardiology Authors: Fikreab Desta Selamawit Mengesha Fanuel Belayneh Demelash Woldeyohannes Yohannes Tekalegn Demisu Zenbaba Biniyam Sahiledengle Dejene Hailu Source Type: research
Magnitude of Thrombocytopenia and Associated Factors among Pregnant Women Attending the Antenatal Care Service Unit of Wachemo University Nigist Ellen Mohammed Comprehensive Specialized Hospital Hosanna, Southern Ethiopia
CONCLUSION: The magnitude of thrombocytopenia in this study was 14.8%. Rural residence, cigarette smoking, alcohol consumption, and anemia were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during antenatal care visits for proper diagnosis and to minimize bleeding during and/or after childbirth.PMID:38655566 | PMC:PMC11039013 | DOI:10.1155/2024/8163447 (Source: Advances in Hematology)
Source: Advances in Hematology - April 24, 2024 Category: Hematology Authors: Dembelo Tirago Tilahun Yemane Edosa Tadasa Source Type: research
Associated factors, incidence, and management of gestational and congenital syphilis in a Brazilian state capital: a cross-sectional study
This study aimed to describe the clinical and epidemiological profile of cases of gestational and congenital syphilis and the hospital care provided for newborns in Campo Grande municipality, Mato Grosso do Sul State, Brazil, from 2013 to 2018. This is a cross-sectional study based on data from Brazilian Notifiable Diseases Surveillance System (SINAN) and hospital medical records. Chi-square or Fisher's exact test and logistic regression analysis were used to assess the associations and relationships between the child's clinical outcome at birth and the mother's clinical-obstetric and epidemiological characteristics. Cumul...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: C ássia de Paula Pires Lisany Krug Mareto M árcio José de Medeiros Everton Falc ão de Oliveira Source Type: research
Survival and mortality profile among people living with HIV in a cohort in the Northeastern region of Brazil
This study aimed to estimate the survival and causes of death according to age group and sex among PLHIV monitored at two referral centers in the Northeastern Brazil. This is a prospective, retrospective cohort with death records from 2007 to 2018, based on a database that registers causes of death using the International Classification of Disease (ICD-10), which were subsequently coded following the Coding Causes of Death in HIV (CoDe). A total of 2,359 PLHIV participated in the study, with 63.2% being men, with a follow-up period of 13.9 years. Annual mortality rate was 1.46 deaths per 100 PLHIV (95% CI: 1.33 - 1.60) wit...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: Kaliene Maria Estev ão Leite Kledoaldo Oliveira Lima Ricardo Arraes de Alencar Ximenes Maria de Fatima Milit ão de Albuquerque Dem ócrito de Barros Miranda-Filho Emmanuelle Ten ório Albuquerque Madruga Godoi Ulisses Ramos Montarroyos Helo ísa Ramos L Source Type: research
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
CONCLUSION: circSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD.PMID:38659023 | DOI:10.1186/s40001-024-01817-4 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: FengJuan Chen YuFeng Xing ZhiJie Chen XiaoMan Chen Jie Li Si Gong Fang Luo QingXian Cai Source Type: research
Spatial Proteomics Reveals Alcohol-Induced Damages to the Crypts and Villi of the Mouse Small Intestine
In this study, we employed laser capture microdissection and a label-free proteomics approach to investigate the consequences of alcohol exposure to the proteomes of crypts and villi in the proximal small intestine. Intestinal tissues from alcohol-fed and pair-fed mice were microdissected to selectively capture cells in the crypts and villi regions, followed by one-pot protein digestion and data-independent LC-MS/MS analysis. We successfully identified over 3000 proteins from each of the crypt or villi regions equivalent to ∼3000 cells. Analysis of alcohol-treated tissues indicated an enhanced alcohol metabolism and redu...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Patil Shivprasad Suresh Xinguo Sun Zhanxiang Zhou Qibin Zhang Source Type: research
Examining within-person associations between alcohol and cannabis use and hooking up among adolescents and young adults in the United States
CONCLUSIONS: Given the significant daily-level associations between alcohol and cannabis use and hooking up behavior, public health initiatives should focus on developing interventions to reduce alcohol and cannabis use and promote safer hooking up behavior among adolescents and young adults.PMID:38657402 | DOI:10.1016/j.addbeh.2024.108040 (Source: Addictive Behaviors)
Source: Addictive Behaviors - April 24, 2024 Category: Addiction Authors: Melissa A Lewis Zhengyang Zhou Anne M Fairlie Dana M Litt Femke Geusens Kathleen A Parks Sean Esteban McCabe Source Type: research
Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230791. doi: 10.1590/0001-3765202420230791. eCollection 2024.ABSTRACTAlthough control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and outcomes between patients with active tuberculosis infection and matched controls. This is a matched case-control study based on data from the Brazilian Covid-19 Registry, in hospitalized patients aged 18 or over with laboratory confirmed Covid-19 from March 1, 2020, to March 31, 2022...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Rafael L R Carvalho Gabriella G Aguiar Jessica F B Moreira Daniella N Pereira Val éria Maria Augusto Alexandre V Schwarzbold Carolina C Matos Danyelle R A Rios Fel ício R Costa Fernando Anschau Jos é Miguel Chatkin Karen B Ruschel Marcelo Carneiro Neim Source Type: research
GSE265758 FABP4 deficiency ameliorates alcoholic steatohepatitis in mice
This study aimed to investigate the function of FABP4 and the underlying mechanisms in the progression of ASH. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus Source Type: research
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
ConclusioncircSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 24, 2024 Category: Research Source Type: research
