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The effects of Atractylodes macrocephala extract BZEP self-microemulsion based on gut-liver axis HDL/LPS signaling pathway to ameliorate metabolic dysfunction-associated fatty liver disease in rats
CONCLUSION: BZEPWR and BZEP exert restorative and reversal effects on the pathophysiological damage to the gut-liver axis in MAFLD rats, and the therapeutic mechanism may be related to the regulation of the intestinal flora and the HDL/LPS signaling pathway.PMID:38663104 | DOI:10.1016/j.biopha.2024.116519 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Bo Li Xiao-Feng Jiang Ying-Jie Dong Yi-Piao Zhang Xing-Li-Shang He Cheng-Liang Zhou Yan-Yan Ding Ning Wang Yi-Bin Wang Wan-Qi Cheng Ning-Hua Jiang Jie Su Gui-Yuan Lv Su-Hong Chen Source Type: research

Environmental Suppression Mediates the Relationship between Posttraumatic Stress and Cannabis Use Among Trauma-Exposed College Students
CONCLUSIONS: Results support the utility of the RPI-ES scale as a transdiagnostic risk factor for both PTS and cannabis use and suggest further investigation into treatment approaches that optimize opportunities for (non-substance) rewarding experiences in the treatment of co-occurring PTS and substance misuse.PMID:38662506 | DOI:10.15288/jsad.23-00344 (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - April 25, 2024 Category: Addiction Authors: Michael Gawrysiak Daniel Loomis Sebastian Ehmann Sam Wayne Mikaela Armao Source Type: research

Sweet taste preference as a moderator of links between internalizing symptoms and alcohol craving
CONCLUSIONS: For those low and moderate in sweet taste preference, internalizing symptoms appeared positively linked with alcohol craving. For those high in sweet taste preference, alcohol craving remained elevated regardless of anxiety symptoms, but appeared to decrease with heightened depressive symptoms. Should future research replicate this finding using controlled research designs that demonstrate temporality and causality, tailored early AUD interventions may be justified based on individuals' levels of sweet taste preference.PMID:38662513 | DOI:10.15288/jsad.23-00107 (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - April 25, 2024 Category: Addiction Authors: Brianna R Altman Tosca D Braun Cynthia L Battle Michael D Stein Sarah Barter Sydney Iacoi Ryan Koch Ana M Abrantes Source Type: research

Secondhand harms from cannabis use: Findings from Washington State, United States
CONCLUSIONS: Augmenting research on individual harms associated with cannabis use by including secondhand impacts such as social and family problems, along with safety risks, provides a more comprehensive picture of the effects of cannabis use.PMID:38662514 | DOI:10.15288/jsad.23-00342 (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - April 25, 2024 Category: Addiction Authors: Thomas K Greenfield Christina C Tam William C Kerr Source Type: research

The Role of Positive and Negative Affect in Illicit Substance Use and Alcohol Use: An Ecological Momentary Assessment Study
CONCLUSION: This study further supported the relation between positive affect and both alcohol and illicit substance use.PMID:38662516 | DOI:10.15288/jsad.23-00067 (Source: Journal of Studies on Alcohol and Drugs)
Source: Journal of Studies on Alcohol and Drugs - April 25, 2024 Category: Addiction Authors: Konrad Bresin Olivia Hatfield Michaela S Ahrenholtz Edelyn Verona Source Type: research

Anxiety connects social media use to food and alcohol disturbance and disordered eating when social support is low
Eat Behav. 2024 Apr 18;53:101879. doi: 10.1016/j.eatbeh.2024.101879. Online ahead of print.ABSTRACTFood and alcohol disturbance (FAD) is an understudied form of disordered eating, in which the consumption of calories is restricted in preparation for drinking alcohol. Guided by previous literature, the present study examined the direct, indirect, and interactive relationships between social media use, anxiety, social support, FAD, and disordered eating among young adults. Recruited from a large southwestern public university, the sample included 679 undergraduate students who completed an online survey in spring of 2022 and...
Source: Eating Behaviors - April 25, 2024 Category: Eating Disorders & Weight Management Authors: William D Murley Crystal D Oberle Krista J Howard Jessica K Perrotte Source Type: research

Cannabis Use Characteristics Associated with Self-Reported Cognitive Function in a Nationally Representative U.S. sample
CONCLUSION: While prospective studies are required to confirm, findings suggest cannabis use is linked to worse cognition. There may be some limited recovery of cognition in former users and some cannabis use characteristics predict impairment. These findings add to our understanding of the cognitive impact of cannabis use. As worse cognitive function may impact relapse, findings have implications for personalization of cannabis use disorder treatment.PMID:38664196 | DOI:10.1080/10826084.2024.2340975 (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - April 25, 2024 Category: Addiction Authors: Dafna Sara Rubin-Kahana Kevin Butler Ahmed Nabeel Hassan Marcos Sanches Bernard Le Foll Source Type: research

A sensitive immunosensor via Pd@Au 0.85 Pd 0.15 in situ electrocatalysis generating H 2 O 2 for quenching electrochemiluminescence of Ir(pbi) 2 (acac)@Ti 3 C 2 T x MXene-PVA
Talanta. 2024 Apr 24;275:126125. doi: 10.1016/j.talanta.2024.126125. Online ahead of print.ABSTRACTThe establishment of rapid target analysis methods for cytokeratin fragment antigen 21-1 (CYFRA 21-1) is urgently needed. [Ir(pbi)2(acac)] (pbi = 2-(4-bromophenyl)-1-hydrogen -benzimidazole, acac = acetylacetonate) as traditional electrochemiluminescence (ECL) luminophores has been confined due to its non-negligible dark toxicity and poor water solubility leading to poor biocompatibility and electrical conductivity as an organic molecule. Hence, to overcome this limitation, [Ir(pbi)2(acac)] can be effectively loaded on the po...
Source: Talanta - April 25, 2024 Category: Chemistry Authors: Xiang Ren Zuoxun Xie Xiaojian Li Dan Wu Huan Wang Yuyang Li Xueying Wang Jinxiu Zhao Qin Wei Source Type: research

Supramolecularly modulated carbon-centered radicals: toward selective oxidation from benzyl alcohol to aldehyde
Chem Commun (Camb). 2024 Apr 25. doi: 10.1039/d4cc01240b. Online ahead of print.ABSTRACTThe reactivity of ketyl radicals and benzoyl radicals, two key intermediates of photo-induced oxidation of benzyl alcohol, can be stabilized by the host-guest interaction of the radicals with cucurbit[7]uril. As a result, the selectivity of photo-induced oxidation from benzyl alcohol to aldehyde is significantly improved by diminishing side reactions and inhibiting the generation of carboxylic acid products. This work presents a new route to modulate the reactivity of radical intermediates, enriching the chemistry of supramolecular inte...
Source: Chemical Communications - April 25, 2024 Category: Chemistry Authors: Xingchen Tang Shan Mei Jiang-Fei Xu Xi Zhang Source Type: research

Non-alcoholic fatty liver disease changes the expression and activity of hepatic drug-metabolizing enzymes and transporters in rats
In conclusion, NALFD changes the expression and activity of hepatic drug-metabolizing enzymes and transporters in rats, which may affect drug metabolism and pharmacokinetics. In clinical medication, drug monitoring should be strengthened to avoid potential risks.PMID:38663832 | DOI:10.1016/j.toxlet.2024.04.010 (Source: Toxicology Letters)
Source: Toxicology Letters - April 25, 2024 Category: Toxicology Authors: Yifei Shen Jie Liu Bingyi Yao Yuanjin Zhang Shengbo Huang Chenmeizi Liang Junze Huang Yu Tang Xin Wang Source Type: research

Association between glycemic status and the risk of gastric cancer in pre-and postmenopausal women: A nationwide cohort study
CONCLUSIONS: The risk of gastric cancer escalates with deteriorating glycemic status in a dose-response manner. Diabetes mellitus is linked with an elevated risk of gastric cancer in postmenopausal women.PMID:38663524 | DOI:10.1016/j.annepidem.2024.04.009 (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - April 25, 2024 Category: Epidemiology Authors: Kyung Hee Han Yoon Jin Choi Tae Il Kim Noh Hyun Park Kyung-do Han Dong Ho Lee Source Type: research

A short-term rodent model for non-alcoholic steatohepatitis induced by a high-fat diet and carbon tetrachloride
This study aimed to evaluate the joint action of a high-fat diet and CCl4 in developing a short-term non-alcoholic steatohepatitis model. C57BL6/J mice were divided into two groups: standard diet-fed (SD), the high-fat diet-fed (HFD) and HFD + fructose-fed and carbon tetrachloride (HFD+CCl4). Animals fed with HFD+CCl4 presented increased lipid deposition compared with both SD and HFD mice. Plasma cholesterol was increased in animals from the HFD+CCl4 group compared to the SD and HFD groups, without significant differences between the SD and HFD groups. Plasma triglycerides showed no significant difference between the group...
Source: Bioscience Reports - April 25, 2024 Category: Biomedical Science Authors: Layanne C C Araujo Carolina C B Dias Felipe G Sucupira Leandra N Z Ramalho Joao Paulo Camporez Source Type: research

Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity
CONCLUSION: FAO patients is associated with decreased mid-to-long-term weight loss outcomes; the alleviation of T2DM, hyperlipidemia and NAFLD; and decreased incidence of acid reflux postoperatively.PMID:38659480 | PMC:PMC11036498 | DOI:10.3748/wjg.v30.i13.1887 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ze-Yu Wang Yun-Fei Qu Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu Source Type: research

Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo
In this study, we investigated the effects of these peptides on IR activation in vitro and in vivo. Using cellular overexpression and endogenous expression models of NEU-1 and IR (COS-7 and HepG2 cells respectively), we have shown that interfering peptides inhibit NEU-1 dimerization and sialidase activity which results in a reduction of IR phosphorylation. These results demonstrated that NEU-1 positively regulates IR phosphorylation and activation in our conditions. In vivo, biodistribution study showed that interfering peptides are well distributed in mice. Treatment of C57Bl/6 mice during eight weeks with interfering pep...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Kevin Toussaint Aline Appert-Collin Laetitia Vanalderwiert Camille Bour Christine Terryn Caroline Spenl é Micha ël Van Der Heyden Mathilde Roumieux Pascal Maurice B éatrice Romier-Crouzet Herv é Sartelet Laurent Duca S ébastien Blaise Amar Bennasroun Source Type: research