36. Investigating the Role of Hippocampal Parvalbumin Interneurons in Schizophrenia-Like Deficits and Alcohol Intake
Schizophrenia is characterized by positive (e.g. hallucinations and delusions) and negative (e.g. anhedonia, social withdrawal) symptoms. Schizophrenia patients are at an increased risk for developing an alcohol use disorder (AUD), which results in worse health and social outcomes. The anterior hippocampus (ventral hippocampus (vHipp) in rodents) has been implicated in the pathology of schizophrenia. Specifically, both schizophrenia patients and rodent models displaying schizophrenia-like deficits show hippocampal hyperactivity, thought to be driven by deficits in parvalbumin (PV)-positive inhibitory interneurons. (Source:...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jamie Palmer, Jennifer Donegan Source Type: research
37. Plasma Level of the Antimicrobial Peptide LL37 (Cathelicidin) is Negatively Associated With Alcohol Use Disorder in US Veterans
We reported lower gene expression of LL-37, an antimicrobial peptide and immunomodulator, in the brains of individuals who died by suicide versus nonpsychiatric controls who died by alternative causes. LL-37 is also reduced in individuals with alcohol use disorder (AUD), as is the LL-37 homologue, cathelicidin-related antimicrobial peptide (CRAMP), in animal models of AUD. We hypothesized that plasma LL-37 will be negatively associated with AUD, other suicide risk factors, and SSDV. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Teodor T. Postolache, Lena Brundin, Erica Duncan, Meghan Barnhart, Joshua Joseph, Aline Dagdag, Carolyn Doty, Mariam Mikadze, John W. Stiller, Christopher A. Lowry, Daniel Roche, Lisa A. Brenner Source Type: research
134. Subjective Response to Alcohol: Childhood Trauma, Bipolar Disorder, and Alcohol-Related Changes in Nucleus Accumbens Functional Connectivity
This study investigated if childhood trauma relates to subjective and neural response to alcohol in young adults with bipolar disorder. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lydia Lovelace, Raquel Kosted, Dylan Kirsch, Kait Meek, Vanessa Le, Elizabeth Lippard Source Type: research
135. Psychiatric Medication and Physiological Responses to Alcohol in Young Adults With Bipolar Disorder
Alcohol use problems occur at higher rates in bipolar disorder than the general population. Youth with bipolar disorder may experience alcohol intoxication differently with this relating to risk for alcohol misuse. It is unclear how psychiatric medication affects response to alcohol in bipolar disorder. This preliminary study investigates physiological responses to alcohol in young adults with bipolar disorder and effects of medication. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nadia Bibb, Dylan Kirsch, Kait Meek, Raquel Kosted, Vanessa Le, Elizabeth Lippard Source Type: research
158. Personal History of Alcohol Use Predicts Antidepressant Efficacy of Ketamine
Antidepressant response to ketamine is greatest in patients with a family history of alcohol use disorder (AUD), however it remains unclear if this is true for a personal history of alcohol use. The purpose of this study is to confirm if an individual history of alcohol use can predict antidepressant response to ketamine. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Aaishah Raquib, Vy Nguyen, Joshua Brown, Stephen Seiner, Joseph Taylor, Robert Meisner, Shan Siddiqi Source Type: research
Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective
World J Gastroenterol. 2024 Apr 21;30(15):2081-2086. doi: 10.3748/wjg.v30.i15.2081.ABSTRACTOver recent years, the nomenclature of non-alcoholic fatty liver disease has undergone significant changes. Indeed, in 2020, an expert consensus panel proposed the term "Metabolic (dysfunction) associated fatty liver disease" (MAFLD) to underscore the close association of fatty liver with metabolic abnormalities, thereby highlighting the cardiometabolic risks (such as metabolic syndrome, type 2 diabetes, insulin resistance, and cardiovascular disease) faced by these patients since childhood. More recently, this term has been further ...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Michele Nardolillo Fabiola Rescigno Mario Bartiromo Dario Piatto Stefano Guarino Pierluigi Marzuillo Emanuele Miraglia Del Giudice Anna Di Sessa Source Type: research
Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
World J Gastroenterol. 2024 Apr 14;30(14):1968-1981. doi: 10.3748/wjg.v30.i14.1968.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease. However, the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies. Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoetiology and suggest functional therapeutic and diagnostic options. Pyroptosis, ferroptosis, and necroptosis are the main subtypes of non-apoptotic regulated cell deaths (RCDs), each of which represents particular characteristic...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song Source Type: research
Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy
CONCLUSIONS: Brief psychosocial interventions may increase the rate of continuous abstinence among pregnant women who report alcohol use during pregnancy. Further studies should be conducted to investigate the efficacy and safety of psychosocial interventions and other treatments (e.g. medications) for women with AUD. These studies should provide detailed information on alcohol use before and during pregnancy using consistent measures such as the number of drinks per drinking day. When heterogeneous populations are recruited, more detailed information on alcohol use during pregnancy should be provided to allow future syste...
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Silvia Minozzi Ludovico Ambrosi Rosella Saulle Seilin S Uhm Mishka Terplan Julia Ma Sinclair Roberta Agabio Source Type: research
Role of the addiction clinical nurse specialist in acute hospital settings
CONCLUSION: Participants indicated several benefits to implementing an ACNS role in their hospital, such as ensuring that patients who misuse substances experienced continuity of care which began at admission, was followed-up during inpatient stays and was maintained in the community.PMID:38680049 | DOI:10.7748/ns.2024.e12305 (Source: Nursing Standard)
Source: Nursing Standard - April 29, 2024 Category: Nursing Authors: Sadie Lavelle-Cafferkey Catherine Comiskey Source Type: research
Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective
World J Gastroenterol. 2024 Apr 21;30(15):2081-2086. doi: 10.3748/wjg.v30.i15.2081.ABSTRACTOver recent years, the nomenclature of non-alcoholic fatty liver disease has undergone significant changes. Indeed, in 2020, an expert consensus panel proposed the term "Metabolic (dysfunction) associated fatty liver disease" (MAFLD) to underscore the close association of fatty liver with metabolic abnormalities, thereby highlighting the cardiometabolic risks (such as metabolic syndrome, type 2 diabetes, insulin resistance, and cardiovascular disease) faced by these patients since childhood. More recently, this term has been further ...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Michele Nardolillo Fabiola Rescigno Mario Bartiromo Dario Piatto Stefano Guarino Pierluigi Marzuillo Emanuele Miraglia Del Giudice Anna Di Sessa Source Type: research
Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
World J Gastroenterol. 2024 Apr 14;30(14):1968-1981. doi: 10.3748/wjg.v30.i14.1968.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease. However, the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies. Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoetiology and suggest functional therapeutic and diagnostic options. Pyroptosis, ferroptosis, and necroptosis are the main subtypes of non-apoptotic regulated cell deaths (RCDs), each of which represents particular characteristic...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song Source Type: research
Mitochondrial dynamics, quality control and mtDNA in Alcohol-associated liver disease and liver cancer
Hepatology. 2024 Apr 29. doi: 10.1097/HEP.0000000000000910. Online ahead of print.ABSTRACTMitochondria are intracellular organelles responsible for energy production, glucose and lipid metabolism, cell death, cell proliferation, and innate immune response. Mitochondria are highly dynamic organelles that constantly undergo fission, fusion, and intracellular trafficking, as well as degradation and biogenesis. Mitochondrial dysfunction has been implicated in a variety of chronic liver diseases including alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatohepatitis (MASH), and hepatocellular carcinom...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Xiaowen Ma Mengwei Niu Hong-Min Ni Wen-Xing Ding Source Type: research
Mounting Stroke Crisis in India: A Systematic Review
Cureus. 2024 Mar 27;16(3):e57058. doi: 10.7759/cureus.57058. eCollection 2024 Mar.ABSTRACTStroke, a neurological disorder, has emerged as a formidable health challenge in India, with its incidence on the rise. Increased risk factors, which also correlate with economic prosperity, are linked to this rise, including hypertension, diabetes, obesity, sedentary lifestyle, and alcohol intake. Particularly worrisome is the impact on young adults, a pivotal segment of India's workforce. Stroke encompasses various clinical subtypes and cerebrovascular disorders (CVDs), contributing to its multifaceted nature. Globally, stroke's esc...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Vedant N Hedau Tushar Patil Source Type: research
Targeted Knockdown of Hepatic delta-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE(-/-) Mice
CONCLUSIONS: Our study demonstrated that knockdown of hepatic Fads1 in ApoE-/- mice aggravates spontaneous atherosclerosis and NAFLD but does not affect peripheral atherosclerosis (femoral artery) induced by vascular cuff combined with tandem stenosis.PMID:38682200 | DOI:10.31083/j.fbl2904131 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Qiulei Liu Peng Wang Zhao Yang Yue Dai Sheng Wang Source Type: research
The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis
CONCLUSIONS: Smoking constitutes a mediating pathway linking depression and anxiety to lung cancer and smoking-related cancers. Our findings underline the importance of smoking cessation interventions for persons with depression or anxiety.PMID:38680088 | DOI:10.1017/S0033291724000850 (Source: Psychological Medicine)
Source: Psychological Medicine - April 29, 2024 Category: Psychiatry Authors: Kuan-Yu Pan Lonneke van Tuijl Maartje Basten Judith J M Rijnhart Alexander de Graeff Joost Dekker Mirjam I Geerlings Adriaan Hoogendoorn Adelita V Ranchor Roel Vermeulen L ützen Portengen Adri C Voogd Jessica Abell Philip Awadalla Aartjan T F Beekman Ott Source Type: research
