Integrating network pharmacology and experimental validation reveals therapeutic effects of D-mannose on NAFLD through mTOR suppression
In this study, network pharmacology followed by molecular docking analysis was utilized to identify potential targets of mannose against NAFLD, and the leptin receptor-deficient, genetically obese db/db mice was employed as an animal model of NAFLD to validate the regulation of D-mannose on core targets. As a result, 67 targets of mannose are predicted associated with NAFLD, which are surprisingly centered on the mechanistic target of rapamycin (mTOR). Further analyses suggest that mTOR signaling is functionally enriched in potential targets of mannose treating NAFLD, and that mannose putatively binds to mTOR as a core mec...
Source: Cell Research - April 28, 2024 Category: Cytology Authors: Sha Zhang Ying-Feng Gao Kai Zhang Guo-Rong Deng Guang-Xiang He Ping-Ping Gao Yi-Kang Yu Yuan Yuan Shu-Juan Xing Na Zhao Hong Zhang Yong-Chang Di-Wu Yi-Han Liu Bing-Dong Sui Zhe Li Jing Ma Chen-Xi Zheng Source Type: research
Anthelmintic efficacy of an organic fraction from Guazuma ulmifolia leaves and evaluation of reactive oxidative stress on Haemonchus contortus
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and su...
Source: Experimental Parasitology - April 28, 2024 Category: Parasitology Authors: Guillermo Res éndiz-González Agust ín Olmedo-Juárez Roberto Gonz ález-Garduño Jorge Alberto Cortes Morales Manas és González Cortazar Ana Elvia S ánchez-Mendoza Mar ía Eugenia López-Arellano Cris óforo Mercado-Márquez Alejandro Lara-Bueno Ros Source Type: research
MiR-18 regulates lipid metabolism of non-alcoholic fatty liver disease via IGF1
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):237-241. doi: 10.14715/cmb/2024.70.4.37.ABSTRACTWe aimed to illustrate the regulatory effect of miR-18 on the onset of non-alcoholic fatty liver disease (NAFLD). MiR-18 level in liver tissues collected from NAFLD patients and mice was detected. In vivo and in vitro influences of miR-18 on biochemical indexes, glucose tolerance and insulin resistance (IR) in NAFLD were determined. H&E staining was conducted to observe hepatic steatosis in NAFLD mice. The downstream target of miR-18 was finally detected by luciferase assay. MiR-18 was upregulated in liver tissues collecte...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hong Yang Bin Zhang Chun Yu Source Type: research
Identification of mRNA expression profiles and their characterization in age-related hearing loss
In this study, we analyzed an mRNA expression dataset (GSE49543) from the GEO database. Differentially expressed genes (DEGs) between young control mice and presbycusis mice were analyzed using limma in R and weighted gene co-expression network analysis (WGCNA) methods. Functional enrichment analyses of the DEGs were conducted with the clusterProfiler R package and the results were visualized using ggplot2 R package. The STRING database was used for the construction of the protein-protein interaction (PPI) network of the screened DEGs. Two machine learning algorithms LASSO and SVM-RFE were used to screen the hub genes. We ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Kanglun Jiang Tan Wang Xinsheng Huang Li Gao Source Type: research
Relationship between changes in blood glucose, glycosylated hemoglobin [HbA1c], cholesterol, and triglyceride and changes in hepatic enzymes
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):23-28. doi: 10.14715/cmb/2024.70.4.4.ABSTRACTThe main risk factors for non-alcoholic fatty liver disease (NAFLD) are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes' activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, this study aimed to investigate the relationship between changes in factors such as blood glucose, cholesterol, glycosylated hemoglobin, and triglyceride and changes in hepat...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Mahboobeh Talebi Mehrdar Wei Lu Adel Rahanjam Source Type: research
Precarious employment in young adulthood and later alcohol-related morbidity: a register-based cohort study
Conclusion
This nationwide register-based study conducted in Sweden with a long-term follow-up suggests that being precariously employed in young adulthood is associated with an increased risk of alcohol-related morbidity later in life. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - April 28, 2024 Category: Occupational Health Authors: Thern, E., Elling, D. L., Badarin, K., Hernando Rodriguez, J. C., Bodin, T. Tags: Open access, Press releases Workplace Source Type: research
Process Evaluation and Investigation of Cultural Adaptations for an Online Parent-Based Intervention Using a Mixed-Method Approach
AbstractMost alcohol intervention research focuses on program efficacy, yet few studies have investigated the acceptability of a program ’s design and implementation to the target population or adapting existing alcohol interventions to different populations. To address these gaps in the literature, we (1) examined participant responsiveness to and implementation quality of FITSTART+, a web-app delivered parent-based alcohol interv ention designed for incoming first-year college students in the United States, and (2) gathered feedback on how this intervention could be adapted to other populations of parents. A sample of ...
Source: The Journal of Primary Prevention - April 28, 2024 Category: Sleep Medicine Source Type: research
Prevalence of Sarcopenia and Its Defining Components in Non-alcoholic Fatty Liver Disease Varies According to the Method of Assessment and Adjustment: Findings from the UK Biobank
This study examined the prevalence of sarcopenia and its defining components in adults with and without NAFLD and whether it varied by the method of muscle mass assessment [bioelectrical impedance (BIA) versus dual-energy X-ray absorptiometry (DXA)] and adjustment (height2 versus BMI). Adults (n = 7266) in the UK Biobank study (45–79 years) with and without NAFLD diagnosed by MRI, were included. Sarcopenia was defined by the 2018 European Working Group on Sarcopenia in Older People definition, with low appendicular skeletal muscle mass (ASM) assessed by BIA and DXA and adjusted for height2 or BMI. Overall, 21% of pa...
Source: Calcified Tissue International - April 28, 2024 Category: Orthopaedics Source Type: research
Sensors, Vol. 24, Pages 2819: Flexible Force Sensor Based on a PVA/AgNWs Nanocomposite and Cellulose Acetate
is-Ramos
Nanocomposites are materials of special interest for the development of flexible electronic, optical, and mechanical devices in applications such as transparent conductive electrodes and flexible electronic sensors. These materials take advantage of the electrical, chemical, and mechanical properties of a polymeric matrix, especially in force sensors, as well as the properties of a conductive filler such as silver nanowires (AgNWs). In this work, the fabrication of a force sensor using AgNWs synthesized via the polyol chemical technique is presented. The nanowires were deposited via drop-casting in polyvinyl a...
Source: Sensors - April 28, 2024 Category: Biotechnology Authors: Dulce Natalia Castillo-L ópez Luz del Carmen G ómez-Pavón Alfredo Gut íerrez-Nava Placido Zaca-Mor án Cesar Augusto Arriaga-Arriaga Jes ús Manuel Muñoz-Pacheco Arnulfo Luis-Ramos Tags: Article Source Type: research
Factors that can influence neurocognitive performance: a case study in a controlled environment
This study provides unique evidence of the impact of balanced nutrition and improvements in psychiatric symptoms on cognition.PMID:38678306 | DOI:10.1080/13554794.2024.2348228 (Source: Neurocase)
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Tiffany Grezmak Kamini Krishnan Source Type: research
Combined superficial keratectomy, alcohol delamination and amniotic membrane patch with fibrin glue in Salzmann nodular degeneration
CONCLUSIONS: Combining alcohol delamination with superficial keratectomy and amniotic membrane patch with fibrin glue is an effective procedure for the management of SND to regularize the corneal surface and avoid the recurrence of subsequent nodules. This report is the first description of the outcomes of SND cases treated with a combination of the aforementioned techniques.PMID:38676318 | DOI:10.1177/11206721241251890 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 27, 2024 Category: Opthalmology Authors: Marco Messina Maria Poddi Nicola De Santi Eduardo Bianchi Carlo Cagini Source Type: research
Environmental sustainability of diets among children and adolescents in the German DONALD cohort study: Age and time trends, and nutrient adequacy
CONCLUSION: Our findings underscore both the further need but also the capacity for change toward more environmentally sustainable diets. Yet, the trade-off between environmental sustainability and nutrient adequacy in diets of children and adolescents requires specific attention to dietary composition.PMID:38677519 | DOI:10.1016/j.ajcnut.2024.04.026 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 27, 2024 Category: Nutrition Authors: Karen van de Locht Ines Perrar Juliana Minetto Gellert Paris Maike Elena Schnermann Kolade Oluwagbemigun Ute Alexy Ute N öthlings Source Type: research
Environmental sustainability of diets among children and adolescents in the German DONALD cohort study: Age and time trends, and nutrient adequacy
CONCLUSION: Our findings underscore both the further need but also the capacity for change toward more environmentally sustainable diets. Yet, the trade-off between environmental sustainability and nutrient adequacy in diets of children and adolescents requires specific attention to dietary composition.PMID:38677519 | DOI:10.1016/j.ajcnut.2024.04.026 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 27, 2024 Category: Nutrition Authors: Karen van de Locht Ines Perrar Juliana Minetto Gellert Paris Maike Elena Schnermann Kolade Oluwagbemigun Ute Alexy Ute N öthlings Source Type: research
Exploring novel indazole derivatives as ASK1 inhibitors: Design, synthesis, biological evaluation and docking studies
Bioorg Chem. 2024 Apr 22;147:107391. doi: 10.1016/j.bioorg.2024.107391. Online ahead of print.ABSTRACTApoptosis signal regulated kinase 1 (ASK1, MAP3K5) is a member of the mitogen activated protein kinase (MAPK) signaling pathway, involved in cell survival, differentiation, stress response, and apoptosis. ASK1 kinase inhibition has become a promising strategy for the treatment of Non-alcoholic steatohepatitis (NASH) disease. A series of novel ASK1 inhibitors with indazole scaffolds were designed and synthesized, and their ASK1 kinase activities were evaluated. The System Structure Activity Relationship (SAR) study discover...
Source: Bioorganic Chemistry - April 27, 2024 Category: Chemistry Authors: Mengni He Jie Wang Wenhua Deng Xiaorui Han Xiumei Wang Lidan Pang Jiateng Huang Pingping Lan Tiantian Wang Zengtao Wang Source Type: research
Incidence of cirrhosis in Iceland-impact of the TraP HepC nationwide HCV elimination program
CONCLUSION: During the past two decades, the incidence of cirrhosis has increased extraordinarily in Iceland, associated with increased alcohol consumption, obesity, and HCV. ALD and MASLD now collectively make up two thirds of cases in Iceland. Following a nationwide elimination program, incidence of HCV cirrhosis has dropped rapidly in Iceland.PMID:38676467 | DOI:10.1080/00365521.2024.2345384 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Authors: Halldor A Haraldsson Sigurdur Olafsson Magnus Gottfredsson Ubaldo Benitez Hernandez Einar S Bjornsson Source Type: research
