Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
World J Gastroenterol. 2024 Apr 14;30(14):1968-1981. doi: 10.3748/wjg.v30.i14.1968.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease. However, the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies. Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoetiology and suggest functional therapeutic and diagnostic options. Pyroptosis, ferroptosis, and necroptosis are the main subtypes of non-apoptotic regulated cell deaths (RCDs), each of which represents particular characteristic...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song Source Type: research
Mitochondrial dynamics, quality control and mtDNA in Alcohol-associated liver disease and liver cancer
Hepatology. 2024 Apr 29. doi: 10.1097/HEP.0000000000000910. Online ahead of print.ABSTRACTMitochondria are intracellular organelles responsible for energy production, glucose and lipid metabolism, cell death, cell proliferation, and innate immune response. Mitochondria are highly dynamic organelles that constantly undergo fission, fusion, and intracellular trafficking, as well as degradation and biogenesis. Mitochondrial dysfunction has been implicated in a variety of chronic liver diseases including alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatohepatitis (MASH), and hepatocellular carcinom...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Xiaowen Ma Mengwei Niu Hong-Min Ni Wen-Xing Ding Source Type: research
Mounting Stroke Crisis in India: A Systematic Review
Cureus. 2024 Mar 27;16(3):e57058. doi: 10.7759/cureus.57058. eCollection 2024 Mar.ABSTRACTStroke, a neurological disorder, has emerged as a formidable health challenge in India, with its incidence on the rise. Increased risk factors, which also correlate with economic prosperity, are linked to this rise, including hypertension, diabetes, obesity, sedentary lifestyle, and alcohol intake. Particularly worrisome is the impact on young adults, a pivotal segment of India's workforce. Stroke encompasses various clinical subtypes and cerebrovascular disorders (CVDs), contributing to its multifaceted nature. Globally, stroke's esc...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Vedant N Hedau Tushar Patil Source Type: research
Targeted Knockdown of Hepatic delta-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE(-/-) Mice
CONCLUSIONS: Our study demonstrated that knockdown of hepatic Fads1 in ApoE-/- mice aggravates spontaneous atherosclerosis and NAFLD but does not affect peripheral atherosclerosis (femoral artery) induced by vascular cuff combined with tandem stenosis.PMID:38682200 | DOI:10.31083/j.fbl2904131 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Qiulei Liu Peng Wang Zhao Yang Yue Dai Sheng Wang Source Type: research
The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis
CONCLUSIONS: Smoking constitutes a mediating pathway linking depression and anxiety to lung cancer and smoking-related cancers. Our findings underline the importance of smoking cessation interventions for persons with depression or anxiety.PMID:38680088 | DOI:10.1017/S0033291724000850 (Source: Psychological Medicine)
Source: Psychological Medicine - April 29, 2024 Category: Psychiatry Authors: Kuan-Yu Pan Lonneke van Tuijl Maartje Basten Judith J M Rijnhart Alexander de Graeff Joost Dekker Mirjam I Geerlings Adriaan Hoogendoorn Adelita V Ranchor Roel Vermeulen L ützen Portengen Adri C Voogd Jessica Abell Philip Awadalla Aartjan T F Beekman Ott Source Type: research
Investigating Alexithymia as a Moderator of Outcomes in a Randomized Controlled Trial of an Online Intervention for Co-Occurring Depression and Hazardous Alcohol Use: Enqu ête sur l'alexithymie en tant que modérateur des résultats dans un essai randomisé contrôlé d'une intervention en ligne pour la dépression concomitante et la consommation dangereuse d'alcool
CONCLUSION: These results suggest that treatment planning and intervention effectiveness could be informed and optimized by taking alexithymia severity into consideration. This is especially merited as alexithymia can contribute to the weaker therapeutic alliance, more distress and dysphoria, shorter periods of abstinence, and more severe depression, compounding the complexity of supporting individuals with comorbid conditions. More research is needed to systematically investigate these possible modifying effects.PLAIN LANGUAGE TITLE: Does difficulty identifying/describing emotions or externally-oriented thinking influence...
Source: Canadian Journal of Psychiatry - April 29, 2024 Category: Psychiatry Authors: Christina Schell Lena C Quilty John A Cunningham Source Type: research
Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease
J Neurosci Res. 2024 May;102(5):e25337. doi: 10.1002/jnr.25337.ABSTRACTHepatic encephalopathy (HE) is defined as decline in neurological function during chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of fibrosis/cirrhosis and has also been documented to directly impact the brain. However, the role of alcohol in the development of HE in CLD remains unclear. Here, we investigated the impact of excessive alcohol administration on neurological deterioration in rats with CLD. Starting day 7 post-BDL surgery, rats were administered alcohol twice daily (51% v/v ethanol, 3 g/kg, via gavage) ...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Farzaneh Tamnanloo Xiaoru Chen Mariana M Oliveira M élanie Tremblay Christopher F Rose Source Type: research
Hyperlipidemia Prevention and Management Utilizing Lifestyle Changes
AbstractHyperlipidemia incidence is on the rise and lifestyle behavior change is the first-line therapy. Left untreated, hyperlipidemia can result in cardiovascular disease leading to increased morbidity and mortality in persons worldwide. Evidence has demonstrated behavioral changes such as increased exercise, healthy nutrition, smoking cessation, alcohol abstinence, and other lifestyle modification interventions significantly decrease the incidence and severity of hyperlipidemia. The purpose of this article is to review the evidence of lifestyle interventions in preventing and managing hyperlipidemia and to suggest innov...
Source: Journal of Midwifery and Women's Health - April 29, 2024 Category: Midwifery Authors: L. Amy Giles Tags: Review Source Type: research
Dietary inflammatory impact on NAFLD development in obese vs. lean individuals: an analysis based on NHANES 2003 –2018
Non-alcoholic fatty liver disease (NAFLD), often linked with obesity, can also affect individuals with normal weight, a condition known as “lean NAFLD”, imposing comparable burdens and adverse effects. However... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 29, 2024 Category: Lipidology Authors: Lurao Li, Xiawen Shu, Yun Yi, Chun Wang, Jianghui Li, Yang Ding, Jin Li and Ying Chang Tags: Research Source Type: research
Analysis of Alcohol Use and Alcohol Use Disorder Trends in U.S. Active-Duty Service Women
Journal of Women's Health, Ahead of Print. (Source: Journal of Women)
Source: Journal of Women - April 29, 2024 Category: OBGYN Authors: Stephanie Tower Amanda Banaag Rachel Sayko Adams Miranda Lynn Janvrin Tracey P érez Koehlmoos Source Type: research
Association of mental health related quality of life and other factors with treatment seeking for substance use disorders: A comparison of SUDs rooted in legal, partially legal, and illegal substances
by John L. Havlik, Taeho G. Rhee, Robert A. Rosenheck
The association of subjective mental health-related quality of life (MHRQOL) and treatment use among people experiencing common substance use disorders (SUDs) is not known. Furthermore, the association of a given substance’s legal status with treatment use has not been studied. This work aims de termine the association of MHRQOL with SUD treatment use, and how substance legal status modulates this relationship. Our analysis used nationally-representative data from the NESARC-III database of those experiencing past-year SUDs (n = 5,808) to compare rates of treatment u...
Source: PLoS One - April 29, 2024 Category: Biomedical Science Authors: John L. Havlik Source Type: research
Liver fat as a dietary target by Chinese Medical Nutrition Therapy (CMNT) diet for treating type 2 diabetes with non-alcoholic fatty liver disease: study protocol for a randomised controlled trial
This study aims to investigate the long-term effect of a Chinese Medical Nutrition Therapy (CMNT) diet accompanied by intermittent energy restriction on reducing liver fat and glycated haemoglobin (HbA1c) in patients with type 2 diabetes and NAFLD.
Methods and analysis
This is a multicentre two-armed parallel randomised controlled trial study. 120 participants with type 2 diabetes and NAFLD will be recruited from the physical examination centres of multiple hospitals in China. Participants will be randomly allocated 1:1 to either the CMNT group or the usual care group. The CMNT group will be instructed to consume the prov...
Source: BMJ Open - April 29, 2024 Category: General Medicine Authors: Luo, W., Xiao, Z., Yang, X., Wu, R., Li, J., Yu, Z., Guo, S., Nie, B., Liu, D. Tags: Open access, Diabetes and Endocrinology Source Type: research
Lifetime costs of alcohol consumption in Thailand: protocol for an incidence-based cost-of-illness study using Markov model
Introduction
Several prevalence-based cost-of-illness (COI) studies have been conducted to estimate the economic burden of alcohol consumption borne by a particular society in a given year. Yet there are few studies examining the economic costs incurred by an individual drinker over his/her lifetime. Thus, this study aims to estimate the costs incurred by an individual drinker’s alcohol consumption over his or her lifetime in Thailand.
Methods and analysis
An incidence-based COI approach will be employed. To project individuals’ associated costs over a lifetime, a Markov modelling technique will be used. The f...
Source: BMJ Open - April 29, 2024 Category: General Medicine Authors: Luangsinsiri, C., Thavorncharoensap, M., Chaikledkaew, U., Pattanaprateep, O., Sornpaisarn, B., Rehm, J. Tags: Open access, Health economics Source Type: research
The Twelve-Step Path? Mindfulness and Ethics in Buddhist Addiction Recovery Literature
This article analyzes the paths laid out by these Buddhist recovery manuals and compares them to classical Buddhist and Twelve-Step paths. This comparison demonstrates that Buddhist recovery manuals creatively draw on classical Buddhism and Twelve-Step but also differ from them in important ways as they re-imagine a path from addiction to recovery. This article documents the growing genre of Buddhist recovery manuals, thus expanding our understanding of Anglophone Buddhism and providing substance abuse professionals with a knowledge of the Buddhist recovery landscape. The article also argues that Buddhist recovery manuals ...
Source: Mindfulness - April 29, 2024 Category: Psychiatry & Psychology Source Type: research
The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation
CONCLUSION: Chronic alcohol exposure-induced impaired mitophagy initiation contributed to NLRP3 inflammasome activation and cognitive deficits, which could be alleviated by NRF2 activation via RTA-408.PMID:38679301 | DOI:10.1016/j.freeradbiomed.2024.04.236 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Xinrou Lin Hongxuan Wang Lubin Zou Biying Yang Wanru Chen Xiaoming Rong Xiaoni Zhang Lei He Xiangpen Li Ying Peng Source Type: research
