The NRF2 activator RTA-408 ameliorates chronic alcohol exposure-induced cognitive impairment and NLRP3 inflammasome activation by modulating impaired mitophagy initiation

CONCLUSION: Chronic alcohol exposure-induced impaired mitophagy initiation contributed to NLRP3 inflammasome activation and cognitive deficits, which could be alleviated by NRF2 activation via RTA-408.PMID:38679301 | DOI:10.1016/j.freeradbiomed.2024.04.236

Source: Free Radical Biology and Medicine - April 28, 2024 Category: Biology Authors: Xinrou Lin Hongxuan Wang Lubin Zou Biying Yang Wanru Chen Xiaoming Rong Xiaoni Zhang Lei He Xiangpen Li Ying Peng Source Type: research