Blood Pressure Control and Associated Factors among Hypertension Comorbid Type 2 Diabetic Patients in Southeast Ethiopia
CONCLUSION: Uncontrolled hypertension was found to be high among hypertension comorbid type 2 diabetic patients. Patients' adherence to antihypertensive medication, physical activity, and alcohol abstinence should be maximized. Loss of weight is also crucial, as is the early detection and management of comorbidities.PMID:38655153 | PMC:PMC11039015 | DOI:10.1155/2024/6668436 (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - April 24, 2024 Category: Cardiology Authors: Fikreab Desta Selamawit Mengesha Fanuel Belayneh Demelash Woldeyohannes Yohannes Tekalegn Demisu Zenbaba Biniyam Sahiledengle Dejene Hailu Source Type: research
Magnitude of Thrombocytopenia and Associated Factors among Pregnant Women Attending the Antenatal Care Service Unit of Wachemo University Nigist Ellen Mohammed Comprehensive Specialized Hospital Hosanna, Southern Ethiopia
CONCLUSION: The magnitude of thrombocytopenia in this study was 14.8%. Rural residence, cigarette smoking, alcohol consumption, and anemia were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during antenatal care visits for proper diagnosis and to minimize bleeding during and/or after childbirth.PMID:38655566 | PMC:PMC11039013 | DOI:10.1155/2024/8163447 (Source: Advances in Hematology)
Source: Advances in Hematology - April 24, 2024 Category: Hematology Authors: Dembelo Tirago Tilahun Yemane Edosa Tadasa Source Type: research
Associated factors, incidence, and management of gestational and congenital syphilis in a Brazilian state capital: a cross-sectional study
This study aimed to describe the clinical and epidemiological profile of cases of gestational and congenital syphilis and the hospital care provided for newborns in Campo Grande municipality, Mato Grosso do Sul State, Brazil, from 2013 to 2018. This is a cross-sectional study based on data from Brazilian Notifiable Diseases Surveillance System (SINAN) and hospital medical records. Chi-square or Fisher's exact test and logistic regression analysis were used to assess the associations and relationships between the child's clinical outcome at birth and the mother's clinical-obstetric and epidemiological characteristics. Cumul...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: C ássia de Paula Pires Lisany Krug Mareto M árcio José de Medeiros Everton Falc ão de Oliveira Source Type: research
Survival and mortality profile among people living with HIV in a cohort in the Northeastern region of Brazil
This study aimed to estimate the survival and causes of death according to age group and sex among PLHIV monitored at two referral centers in the Northeastern Brazil. This is a prospective, retrospective cohort with death records from 2007 to 2018, based on a database that registers causes of death using the International Classification of Disease (ICD-10), which were subsequently coded following the Coding Causes of Death in HIV (CoDe). A total of 2,359 PLHIV participated in the study, with 63.2% being men, with a follow-up period of 13.9 years. Annual mortality rate was 1.46 deaths per 100 PLHIV (95% CI: 1.33 - 1.60) wit...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: Kaliene Maria Estev ão Leite Kledoaldo Oliveira Lima Ricardo Arraes de Alencar Ximenes Maria de Fatima Milit ão de Albuquerque Dem ócrito de Barros Miranda-Filho Emmanuelle Ten ório Albuquerque Madruga Godoi Ulisses Ramos Montarroyos Helo ísa Ramos L Source Type: research
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
CONCLUSION: circSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD.PMID:38659023 | DOI:10.1186/s40001-024-01817-4 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: FengJuan Chen YuFeng Xing ZhiJie Chen XiaoMan Chen Jie Li Si Gong Fang Luo QingXian Cai Source Type: research
Spatial Proteomics Reveals Alcohol-Induced Damages to the Crypts and Villi of the Mouse Small Intestine
In this study, we employed laser capture microdissection and a label-free proteomics approach to investigate the consequences of alcohol exposure to the proteomes of crypts and villi in the proximal small intestine. Intestinal tissues from alcohol-fed and pair-fed mice were microdissected to selectively capture cells in the crypts and villi regions, followed by one-pot protein digestion and data-independent LC-MS/MS analysis. We successfully identified over 3000 proteins from each of the crypt or villi regions equivalent to ∼3000 cells. Analysis of alcohol-treated tissues indicated an enhanced alcohol metabolism and redu...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Patil Shivprasad Suresh Xinguo Sun Zhanxiang Zhou Qibin Zhang Source Type: research
Examining within-person associations between alcohol and cannabis use and hooking up among adolescents and young adults in the United States
CONCLUSIONS: Given the significant daily-level associations between alcohol and cannabis use and hooking up behavior, public health initiatives should focus on developing interventions to reduce alcohol and cannabis use and promote safer hooking up behavior among adolescents and young adults.PMID:38657402 | DOI:10.1016/j.addbeh.2024.108040 (Source: Addictive Behaviors)
Source: Addictive Behaviors - April 24, 2024 Category: Addiction Authors: Melissa A Lewis Zhengyang Zhou Anne M Fairlie Dana M Litt Femke Geusens Kathleen A Parks Sean Esteban McCabe Source Type: research
Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230791. doi: 10.1590/0001-3765202420230791. eCollection 2024.ABSTRACTAlthough control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and outcomes between patients with active tuberculosis infection and matched controls. This is a matched case-control study based on data from the Brazilian Covid-19 Registry, in hospitalized patients aged 18 or over with laboratory confirmed Covid-19 from March 1, 2020, to March 31, 2022...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Rafael L R Carvalho Gabriella G Aguiar Jessica F B Moreira Daniella N Pereira Val éria Maria Augusto Alexandre V Schwarzbold Carolina C Matos Danyelle R A Rios Fel ício R Costa Fernando Anschau Jos é Miguel Chatkin Karen B Ruschel Marcelo Carneiro Neim Source Type: research
GSE265758 FABP4 deficiency ameliorates alcoholic steatohepatitis in mice
This study aimed to investigate the function of FABP4 and the underlying mechanisms in the progression of ASH. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus Source Type: research
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
ConclusioncircSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 24, 2024 Category: Research Source Type: research
Psychometric Analysis for a Standardized Approach When Evaluating Liver Transplant Candidates with Acute Alcohol-Related Hepatitis
AbstractPurpose of ReviewTo summarize the role of psychometric instruments in the evaluation and management of patients with acute alcoholic hepatitis (AAH) evaluated for liver transplantation (LT).Recent FindingsPsychometrics can inform the care of patients with AAH in the transplantation setting by enhancing diagnostic accuracy and allowing a more precise understanding of the patient ’s mental health status. The predictive value of the psychometric scale in LT candidates with AAH remains low and controversial.SummaryCombining psychometrics with clinical judgment and other diagnostic tools ensures a more comprehensive a...
Source: Current Transplantation Reports - April 24, 2024 Category: Transplant Surgery Source Type: research
Targeting EFHD2 Inhibits Interferon- γ Signaling and Ameliorates Non-Alcoholic Steatohepatitis
This study investigates the potential role of EF-hand domain family member D2 (EFHD2), a novel molecule specific to immune cells, in NASH pathogenesis. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 24, 2024 Category: Gastroenterology Authors: Jiang-Tao Fu, Jian Liu, Wen-Bin Wu, Yi-Ting Chen, Guo-Dong Lu, Qi Cao, Hong-Bo Meng, Jie Tong, Jia-Hui Zhu, Xu-Jie Wang, Yi Liu, Chunlin Zhuang, Chunquan Sheng, Fu-Ming Shen, Xingguang Liu, Hua Wang, Yongsheng Yu, Yuefan Zhang, Hai-Yan Liang, Jia-Bao Zhan Tags: Research Article Source Type: research
SMARCA4-Deficient Undifferentiated Esophageal Carcinoma: A Clinical Case Series and Literature Review
ConclusionsResearch in SMARCA-deficient UEC is very limited. It is more common in men, age is variable, and associated with Barret ’s esophagus. Further research is necessary to better understand it and to establish treatment guidelines; however, it is clear that SMARCA4-deficient UEC carries a significantly poor prognosis. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 24, 2024 Category: Cancer & Oncology Source Type: research
Investigating human-derived lactic acid bacteria for alcohol resistance
Excessive alcohol consumption has been consistently linked to serious adverse health effects, particularly affecting the liver. One natural defense against the detrimental impacts of alcohol is provided by alc... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 24, 2024 Category: Microbiology Authors: Sini Kang, Jing Long, Myeong Soo Park, Geun Eog Ji, Ying Ju and Seockmo Ku Tags: Research Source Type: research
Benchmark dose profiles for bivariate exposures
AbstractWhile benchmark dose (BMD) methodology is well-established for settings with a single exposure, these methods cannot easily handle multidimensional exposures with nonlinear effects. We propose a framework for BMD analysis to characterize the joint effect of a two-dimensional exposure on a continuous outcome using a generalized additive model while adjusting for potential confounders via propensity scores. This leads to a dose –response surface which can be summarized in two dimensions by a contour plot in which combinations of exposures leading to the same expected effect are identified. In our motivating study o...
Source: Risk Analysis - April 23, 2024 Category: International Medicine & Public Health Authors: Tugba Akkaya Hocagil,
Louise M. Ryan,
Richard J. Cook,
Khue ‐Dung Dang,
R. Colin Carter,
Gale A. Richardson,
Nancy L. Day,
Claire D. Coles,
Heather Carmichael Olson,
Sandra W. Jacobson,
Joseph L. Jacobson Tags: ORIGINAL ARTICLE Source Type: research
