Trend in infant mortality rate caused by sepsis in Brazil from 2009 to 2018
Rev Inst Med Trop Sao Paulo. 2021 Apr 12;63:e26. doi: 10.1590/S1678-9946202163026. eCollection 2021.ABSTRACTSepsis is the organ dysfunction resulting from an infection associated with an unregulated host inflammatory response, which generates high mortality rates in Brazil. The aim of this stydy was to analyze the trend of early, late and post-neonatal mortality rates due to sepsis in Brazilian regions, from 2009 to 2018. This is an ecological study of time series. The trend of infant mortality from sepsis was analyzed using the International Classification of Diseases (ICD10) according to the place of residence (North, No...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 14, 2021 Category: Tropical Medicine Authors: Liliane Dos Santos Rodrigues Livia Dos Santos Rodrigues Luciana Cavalcante Costa Guilherme Martins Gomes Fontoura M árcia Cristina Gonçalves Maciel Source Type: research

Susceptibility to chlorhexidine and mupirocin among methicillin-resistant Staphylococcus aureus clinical isolates from a teaching hospital
Rev Inst Med Trop Sao Paulo. 2021 Apr 12;63:e27. doi: 10.1590/S1678-9946202163027. eCollection 2021.ABSTRACTDespite the widespread use of chlorhexidine (CHX) to prevent infection, data regarding the in vitro action of CHX against methicillin-resistant Staphylococcus aureus (MRSA) are limited. Clinical isolates from Hospital das Clinicas, Sao Paulo, Brazil, identified during 2002/2003 and 2012/2013 were studied to describe the susceptibility to CHX and mupirocin, molecular characteristics, and virulence profile of MRSA. Susceptibility test to Mupirocin was performed by the disk diffusion method and to CHX by the agar diluti...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 14, 2021 Category: Tropical Medicine Authors: Taniela Marli Bes Lauro Perdig ão-Neto Roberta Ruedas Martins Inneke Heijden Priscila de Arruda Trindade Gaspar Camilo Debora Satie Nagano Diego Mongelos Ana Paula Marchi Mariama Tomaz Larissa Marques de Oliveira Flavia Rossi Anna Sara Levin Silvia Figue Source Type: research

Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection
Rev Inst Med Trop Sao Paulo. 2021 Apr 12;63:e28. doi: 10.1590/S1678-9946202163028. eCollection 2021.ABSTRACTCurrently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 14, 2021 Category: Tropical Medicine Authors: Caio Vinicius Botelho Brito Érika Dayane Leal Rodrigues Fernanda Monik Silva Martins Lavinia Dias Tavares Andr é Luis de Sousa Nogueira Lima Lucas Carvalho Ferreira Carlos Junior Lopes Santana Jo ão Augusto Gomes de Souza Monteiro de Brito L ívia Mede Source Type: research

Prevalence of trachoma in Pernambuco State, Brazil (2014-2015)
Rev Inst Med Trop Sao Paulo. 2021 Apr 12;63:e29. doi: 10.1590/S1678-9946202163029. eCollection 2021.ABSTRACTTo estimate the prevalence of cases of trachoma in the population at social risk aged 1-9 years in Pernambuco State and its mesoregions. This was a cross-sectional study in which secondary data from the National Household Survey on Trachoma (2014-2015) were analyzed. The study covered 96 census tracts distributed across the mesoregions of Pernambuco State (Metropolitan Region of Recife, Zona da Mata, Agreste, Sertao do Sao Francisco and Sertao Pernambucano). The study included all homes with children aged 1-9 years, ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 14, 2021 Category: Tropical Medicine Authors: Cintia Michele Gondim de Brito Zulma Maria de Medeiros Celivane Cavalcanti Barbosa Ulisses Ramos Montarroyos Cristiano Ferraz Marcel de Toledo Vieira Maria de F átima Costa Lopes Giselle Campozana Gouveia Source Type: research

Antimicrobial treatment of Erysipelatoclostridium ramosum invasive infections: a systematic review
Rev Inst Med Trop Sao Paulo. 2021 Apr 12;63:e30. doi: 10.1590/S1678-9946202163030. eCollection 2021.ABSTRACTThe aim of this systematic review was to determine the causal role of Erysipelatoclostridium ramosum in specific invasive infections in humans, and to assess the clinical outcome of antibiotic therapy used to treat them. Several electronic databases were systematically searched for clinical trials, observational studies or individual cases on patients of any age and gender with a systemic inflammatory response syndrome (SIRS) due to E. ramosum isolated from body fluids or tissues in which it is not normally present. ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 14, 2021 Category: Tropical Medicine Authors: Milos N Milosavljevic Marina Kostic Jasmina Milovanovic Radica Zivkovic Zaric Milorad Stojadinovic Slobodan M Jankovic Srdjan M Stefanovic Source Type: research

Epidemiological and genetic aspects of the largest dengue outbreak recorded in 2015 in Southeastern Brazil
In this study, characteristics of 2007 DENV epidemics were compared to the epidemiological, hematological and demographic outlines of the major outbreak of DENV1 in Marilia in 2015. DENV1 genetic diversity was assessed through capsid and pre-membrane junction encoding gene (CprM) sequencing. The results revealed circulation of DENV1 serotype from 2007 to 2015, with epidemics occurring every three-years until 2013 and then, increasing yearly. There were significant differences in hematological profiles of DENV1 patients between 2015 and 2007. CprM showed DENV1 genetic variability in 2015, contrasting with the unique sequenc...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Aline Diniz Cabral Luana Prado Rolim de Oliveira Juliana S á Teles de Oliveira Molina Andreia Moreira Dos Santos Carmo Rodrigo Buzinaro Suzuki Camila Marcondes de Oliveira Luciamare Perinetti Alves Martins Carlos Roberto Prudencio Andr é Eterovic M árc Source Type: research

Aerococcus spp infective endocarditis following a prostate biopsy: a case report
We report a rare case of an infective endocarditis by Aerococcus spp in a bioprosthetic aortic valve following a prostate biopsy, in an asymptomatic adult with no additional risk factor for prostate cancer, excepting for age. The diagnosis was based on the presence of vegetations on the bioprosthesis seen on the echocardiogram, positive blood cultures and fever, and a favorable clinical outcome following the treatment with ceftriaxone and gentamicin.PMID:33787738 | PMC:PMC7997663 | DOI:10.1590/S1678-9946202163018 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Marcelo Ant ônio Oliveira Santos-Veloso Maria das Neves Dantas da Silveira Barros Marcos Holmes Carvalho Daniela Azevedo de Carvalho Kamel Barbosa Jorge Vieira Rodrigues Source Type: research

Molecular characterization of mutations associated with resistance to second line drugs in Mycobacterium tuberculosis patients from Casablanca, Morocco
This study is very informative and provides data on the alarming rate of fluoroquinolone resistance which warrants the need to implement appropriate drug regimens to prevent the emergence and spread of more severe forms of Mycobacterium tuberculosis drug resistance.PMID:33787739 | PMC:PMC7997671 | DOI:10.1590/S1678-9946202163019 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Ghizlane Momen Aainouss Achraf Lamaammal Abdelmajid Chetioui Fouad Blaghen Mohamed Messaoudi Malika Belghmi Khalid Mouslim Jamal El Mzibri Mohammed El Messaoudi My Driss Khyatti Meriem Chaoui Imane Source Type: research

Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit
In conclusion, we found that C. parapsilosis was the main pathogen among the NCAC candidemia in the ICU patients. APACHE II scores, central venous catheterization and the use of broad-spectrum antibiotics were independent risk factors for the occurrence of C. parapsilosis candidemia, which may provide data to support the early introduction of anti-fungal therapy.PMID:33787740 | PMC:PMC7997672 | DOI:10.1590/S1678-9946202163020 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Xiao-Shu Zuo Yanan Liu Ke Hu Source Type: research

Spatiotemporal dynamics and risk estimates of COVID-19 epidemic in Minas Gerais State: analysis of an expanding process
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e21. doi: 10.1590/S1678-9946202163021. eCollection 2021.ABSTRACTCOVID-19 is an infectious disease caused by the recently discovered coronavirus SARS-Cov-2. The disease became pandemic affecting many countries globally, including Brazil. Considering the expansion process and particularities during the initial stages of the epidemic, we aimed to analyze the spatial and spatiotemporal patterns of COVID-19 occurrence and to identify priority risk areas in Minas Gerais State, Southeast Brazil. An ecological study was performed considering all data from human cases of COVID-19 confirme...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Wendel Coura-Vital Diogo Tavares Cardoso Fabricio Thomaz de Oliveira Ker Fernanda do Carmo Magalh ães Juliana Maria Trindade Bezerra Ana Maria Viegas Maria Helena Franco Morais Leonardo Soares Bastos Ilka Afonso Reis Mari ângela Carneiro David Soeiro Ba Source Type: research

Isolated cutaneous lesions in paracoccidioidomycosis: a suggestive case of acquisition through cutaneous inoculation
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e22. doi: 10.1590/S1678-9946202163022. eCollection 2021.NO ABSTRACTPMID:33787742 | PMC:PMC7997668 | DOI:10.1590/S1678-9946202163022 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fernanda Brand ão Pacheco Nat ália Andressa Buss Venier Ana Laura Bueno Alice Lopes de Almeida Laura Milman Alessandra Koehler Danielle Machado Pagani Maria L úcia Scroferneker Source Type: research

Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e23. doi: 10.1590/S1678-9946202163023. eCollection 2021.ABSTRACTHuman immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fl ávia Esper Dahy Christina T G Novaes Gabriela A Bandeira La ís F Ramin Augusto C ésar Penalva de Oliveira Jerusa Smid Source Type: research

Molecular characterization of mosquitoes (Diptera: Culicidae) from the Colombian rainforest
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e24. doi: 10.1590/S1678-9946202163024. eCollection 2021.ABSTRACTA few studies have carried out the taxonomic and molecular characterization of sylvatic mosquito species in Latin America, where some species have been incriminated as vectors for arboviruses and parasites transmission. The present study reports the molecular characterization of mosquito species in the Sierra Nevada de Santa Marta, a natural ecosystem in the Northern coast of Colombia. Manual capture methods were used to collect mosquitoes, and the specimens were identified via classical taxonomy. The COI marker was ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Andrew S Mu ñoz-Gamba Katherine Laiton-Donato Erick Perdomo-Balaguera Lyda R Castro Jos é A Usme-Ciro Gabriel Parra-Henao Source Type: research

Challenges faced by health workers in the use of the directly observed treatment (DOT) for tuberculosis
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e25. doi: 10.1590/S1678-9946202163025. eCollection 2021.ABSTRACTTuberculosis is a worldwide public health problem, which, even with available treatment, continues to cause deaths worldwide. One of the obstacles to control the disease is the multifactorial difficulty of patients to adhere to treatment, in addition to the difficulty of health workers in circumventing barriers to implement strategies such as the directly observed treatment (DOT). The aim of this study is to analyze the performance and challenges faced by health workers in the use of DOT in tuberculosis. This is a de...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Simone Sardeto Valloto Dalazoana Betina Mendez Alc ântara Gabardo Rosilene Fressatti Cardoso Source Type: research

Epidemiological and genetic aspects of the largest dengue outbreak recorded in 2015 in Southeastern Brazil
In this study, characteristics of 2007 DENV epidemics were compared to the epidemiological, hematological and demographic outlines of the major outbreak of DENV1 in Marilia in 2015. DENV1 genetic diversity was assessed through capsid and pre-membrane junction encoding gene (CprM) sequencing. The results revealed circulation of DENV1 serotype from 2007 to 2015, with epidemics occurring every three-years until 2013 and then, increasing yearly. There were significant differences in hematological profiles of DENV1 patients between 2015 and 2007. CprM showed DENV1 genetic variability in 2015, contrasting with the unique sequenc...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Aline Diniz Cabral Luana Prado Rolim de Oliveira Juliana S á Teles de Oliveira Molina Andreia Moreira Dos Santos Carmo Rodrigo Buzinaro Suzuki Camila Marcondes de Oliveira Luciamare Perinetti Alves Martins Carlos Roberto Prudencio Andr é Eterovic M árc Source Type: research

Aerococcus spp infective endocarditis following a prostate biopsy: a case report
We report a rare case of an infective endocarditis by Aerococcus spp in a bioprosthetic aortic valve following a prostate biopsy, in an asymptomatic adult with no additional risk factor for prostate cancer, excepting for age. The diagnosis was based on the presence of vegetations on the bioprosthesis seen on the echocardiogram, positive blood cultures and fever, and a favorable clinical outcome following the treatment with ceftriaxone and gentamicin.PMID:33787738 | PMC:PMC7997663 | DOI:10.1590/S1678-9946202163018 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Marcelo Ant ônio Oliveira Santos-Veloso Maria das Neves Dantas da Silveira Barros Marcos Holmes Carvalho Daniela Azevedo de Carvalho Kamel Barbosa Jorge Vieira Rodrigues Source Type: research

Molecular characterization of mutations associated with resistance to second line drugs in Mycobacterium tuberculosis patients from Casablanca, Morocco
This study is very informative and provides data on the alarming rate of fluoroquinolone resistance which warrants the need to implement appropriate drug regimens to prevent the emergence and spread of more severe forms of Mycobacterium tuberculosis drug resistance.PMID:33787739 | PMC:PMC7997671 | DOI:10.1590/S1678-9946202163019 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Ghizlane Momen Aainouss Achraf Lamaammal Abdelmajid Chetioui Fouad Blaghen Mohamed Messaoudi Malika Belghmi Khalid Mouslim Jamal El Mzibri Mohammed El Messaoudi My Driss Khyatti Meriem Chaoui Imane Source Type: research

Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit
In conclusion, we found that C. parapsilosis was the main pathogen among the NCAC candidemia in the ICU patients. APACHE II scores, central venous catheterization and the use of broad-spectrum antibiotics were independent risk factors for the occurrence of C. parapsilosis candidemia, which may provide data to support the early introduction of anti-fungal therapy.PMID:33787740 | PMC:PMC7997672 | DOI:10.1590/S1678-9946202163020 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Xiao-Shu Zuo Yanan Liu Ke Hu Source Type: research

Spatiotemporal dynamics and risk estimates of COVID-19 epidemic in Minas Gerais State: analysis of an expanding process
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e21. doi: 10.1590/S1678-9946202163021. eCollection 2021.ABSTRACTCOVID-19 is an infectious disease caused by the recently discovered coronavirus SARS-Cov-2. The disease became pandemic affecting many countries globally, including Brazil. Considering the expansion process and particularities during the initial stages of the epidemic, we aimed to analyze the spatial and spatiotemporal patterns of COVID-19 occurrence and to identify priority risk areas in Minas Gerais State, Southeast Brazil. An ecological study was performed considering all data from human cases of COVID-19 confirme...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Wendel Coura-Vital Diogo Tavares Cardoso Fabricio Thomaz de Oliveira Ker Fernanda do Carmo Magalh ães Juliana Maria Trindade Bezerra Ana Maria Viegas Maria Helena Franco Morais Leonardo Soares Bastos Ilka Afonso Reis Mari ângela Carneiro David Soeiro Ba Source Type: research

Isolated cutaneous lesions in paracoccidioidomycosis: a suggestive case of acquisition through cutaneous inoculation
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e22. doi: 10.1590/S1678-9946202163022. eCollection 2021.NO ABSTRACTPMID:33787742 | PMC:PMC7997668 | DOI:10.1590/S1678-9946202163022 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fernanda Brand ão Pacheco Nat ália Andressa Buss Venier Ana Laura Bueno Alice Lopes de Almeida Laura Milman Alessandra Koehler Danielle Machado Pagani Maria L úcia Scroferneker Source Type: research

Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e23. doi: 10.1590/S1678-9946202163023. eCollection 2021.ABSTRACTHuman immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fl ávia Esper Dahy Christina T G Novaes Gabriela A Bandeira La ís F Ramin Augusto C ésar Penalva de Oliveira Jerusa Smid Source Type: research

Molecular characterization of mosquitoes (Diptera: Culicidae) from the Colombian rainforest
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e24. doi: 10.1590/S1678-9946202163024. eCollection 2021.ABSTRACTA few studies have carried out the taxonomic and molecular characterization of sylvatic mosquito species in Latin America, where some species have been incriminated as vectors for arboviruses and parasites transmission. The present study reports the molecular characterization of mosquito species in the Sierra Nevada de Santa Marta, a natural ecosystem in the Northern coast of Colombia. Manual capture methods were used to collect mosquitoes, and the specimens were identified via classical taxonomy. The COI marker was ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Andrew S Mu ñoz-Gamba Katherine Laiton-Donato Erick Perdomo-Balaguera Lyda R Castro Jos é A Usme-Ciro Gabriel Parra-Henao Source Type: research

Challenges faced by health workers in the use of the directly observed treatment (DOT) for tuberculosis
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e25. doi: 10.1590/S1678-9946202163025. eCollection 2021.ABSTRACTTuberculosis is a worldwide public health problem, which, even with available treatment, continues to cause deaths worldwide. One of the obstacles to control the disease is the multifactorial difficulty of patients to adhere to treatment, in addition to the difficulty of health workers in circumventing barriers to implement strategies such as the directly observed treatment (DOT). The aim of this study is to analyze the performance and challenges faced by health workers in the use of DOT in tuberculosis. This is a de...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Simone Sardeto Valloto Dalazoana Betina Mendez Alc ântara Gabardo Rosilene Fressatti Cardoso Source Type: research

Epidemiological and genetic aspects of the largest dengue outbreak recorded in 2015 in Southeastern Brazil
In this study, characteristics of 2007 DENV epidemics were compared to the epidemiological, hematological and demographic outlines of the major outbreak of DENV1 in Marilia in 2015. DENV1 genetic diversity was assessed through capsid and pre-membrane junction encoding gene (CprM) sequencing. The results revealed circulation of DENV1 serotype from 2007 to 2015, with epidemics occurring every three-years until 2013 and then, increasing yearly. There were significant differences in hematological profiles of DENV1 patients between 2015 and 2007. CprM showed DENV1 genetic variability in 2015, contrasting with the unique sequenc...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Aline Diniz Cabral Luana Prado Rolim de Oliveira Juliana S á Teles de Oliveira Molina Andreia Moreira Dos Santos Carmo Rodrigo Buzinaro Suzuki Camila Marcondes de Oliveira Luciamare Perinetti Alves Martins Carlos Roberto Prudencio Andr é Eterovic M árc Source Type: research

Aerococcus spp infective endocarditis following a prostate biopsy: a case report
We report a rare case of an infective endocarditis by Aerococcus spp in a bioprosthetic aortic valve following a prostate biopsy, in an asymptomatic adult with no additional risk factor for prostate cancer, excepting for age. The diagnosis was based on the presence of vegetations on the bioprosthesis seen on the echocardiogram, positive blood cultures and fever, and a favorable clinical outcome following the treatment with ceftriaxone and gentamicin.PMID:33787738 | PMC:PMC7997663 | DOI:10.1590/S1678-9946202163018 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Marcelo Ant ônio Oliveira Santos-Veloso Maria das Neves Dantas da Silveira Barros Marcos Holmes Carvalho Daniela Azevedo de Carvalho Kamel Barbosa Jorge Vieira Rodrigues Source Type: research

Molecular characterization of mutations associated with resistance to second line drugs in Mycobacterium tuberculosis patients from Casablanca, Morocco
This study is very informative and provides data on the alarming rate of fluoroquinolone resistance which warrants the need to implement appropriate drug regimens to prevent the emergence and spread of more severe forms of Mycobacterium tuberculosis drug resistance.PMID:33787739 | PMC:PMC7997671 | DOI:10.1590/S1678-9946202163019 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Ghizlane Momen Aainouss Achraf Lamaammal Abdelmajid Chetioui Fouad Blaghen Mohamed Messaoudi Malika Belghmi Khalid Mouslim Jamal El Mzibri Mohammed El Messaoudi My Driss Khyatti Meriem Chaoui Imane Source Type: research

Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit
In conclusion, we found that C. parapsilosis was the main pathogen among the NCAC candidemia in the ICU patients. APACHE II scores, central venous catheterization and the use of broad-spectrum antibiotics were independent risk factors for the occurrence of C. parapsilosis candidemia, which may provide data to support the early introduction of anti-fungal therapy.PMID:33787740 | PMC:PMC7997672 | DOI:10.1590/S1678-9946202163020 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Xiao-Shu Zuo Yanan Liu Ke Hu Source Type: research

Spatiotemporal dynamics and risk estimates of COVID-19 epidemic in Minas Gerais State: analysis of an expanding process
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e21. doi: 10.1590/S1678-9946202163021. eCollection 2021.ABSTRACTCOVID-19 is an infectious disease caused by the recently discovered coronavirus SARS-Cov-2. The disease became pandemic affecting many countries globally, including Brazil. Considering the expansion process and particularities during the initial stages of the epidemic, we aimed to analyze the spatial and spatiotemporal patterns of COVID-19 occurrence and to identify priority risk areas in Minas Gerais State, Southeast Brazil. An ecological study was performed considering all data from human cases of COVID-19 confirme...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Wendel Coura-Vital Diogo Tavares Cardoso Fabricio Thomaz de Oliveira Ker Fernanda do Carmo Magalh ães Juliana Maria Trindade Bezerra Ana Maria Viegas Maria Helena Franco Morais Leonardo Soares Bastos Ilka Afonso Reis Mari ângela Carneiro David Soeiro Ba Source Type: research

Isolated cutaneous lesions in paracoccidioidomycosis: a suggestive case of acquisition through cutaneous inoculation
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e22. doi: 10.1590/S1678-9946202163022. eCollection 2021.NO ABSTRACTPMID:33787742 | PMC:PMC7997668 | DOI:10.1590/S1678-9946202163022 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fernanda Brand ão Pacheco Nat ália Andressa Buss Venier Ana Laura Bueno Alice Lopes de Almeida Laura Milman Alessandra Koehler Danielle Machado Pagani Maria L úcia Scroferneker Source Type: research

Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e23. doi: 10.1590/S1678-9946202163023. eCollection 2021.ABSTRACTHuman immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fl ávia Esper Dahy Christina T G Novaes Gabriela A Bandeira La ís F Ramin Augusto C ésar Penalva de Oliveira Jerusa Smid Source Type: research

Molecular characterization of mosquitoes (Diptera: Culicidae) from the Colombian rainforest
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e24. doi: 10.1590/S1678-9946202163024. eCollection 2021.ABSTRACTA few studies have carried out the taxonomic and molecular characterization of sylvatic mosquito species in Latin America, where some species have been incriminated as vectors for arboviruses and parasites transmission. The present study reports the molecular characterization of mosquito species in the Sierra Nevada de Santa Marta, a natural ecosystem in the Northern coast of Colombia. Manual capture methods were used to collect mosquitoes, and the specimens were identified via classical taxonomy. The COI marker was ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Andrew S Mu ñoz-Gamba Katherine Laiton-Donato Erick Perdomo-Balaguera Lyda R Castro Jos é A Usme-Ciro Gabriel Parra-Henao Source Type: research

Challenges faced by health workers in the use of the directly observed treatment (DOT) for tuberculosis
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e25. doi: 10.1590/S1678-9946202163025. eCollection 2021.ABSTRACTTuberculosis is a worldwide public health problem, which, even with available treatment, continues to cause deaths worldwide. One of the obstacles to control the disease is the multifactorial difficulty of patients to adhere to treatment, in addition to the difficulty of health workers in circumventing barriers to implement strategies such as the directly observed treatment (DOT). The aim of this study is to analyze the performance and challenges faced by health workers in the use of DOT in tuberculosis. This is a de...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Simone Sardeto Valloto Dalazoana Betina Mendez Alc ântara Gabardo Rosilene Fressatti Cardoso Source Type: research

Epidemiological and genetic aspects of the largest dengue outbreak recorded in 2015 in Southeastern Brazil
In this study, characteristics of 2007 DENV epidemics were compared to the epidemiological, hematological and demographic outlines of the major outbreak of DENV1 in Marilia in 2015. DENV1 genetic diversity was assessed through capsid and pre-membrane junction encoding gene (CprM) sequencing. The results revealed circulation of DENV1 serotype from 2007 to 2015, with epidemics occurring every three-years until 2013 and then, increasing yearly. There were significant differences in hematological profiles of DENV1 patients between 2015 and 2007. CprM showed DENV1 genetic variability in 2015, contrasting with the unique sequenc...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Aline Diniz Cabral Luana Prado Rolim de Oliveira Juliana S á Teles de Oliveira Molina Andreia Moreira Dos Santos Carmo Rodrigo Buzinaro Suzuki Camila Marcondes de Oliveira Luciamare Perinetti Alves Martins Carlos Roberto Prudencio Andr é Eterovic M árc Source Type: research

Aerococcus spp infective endocarditis following a prostate biopsy: a case report
We report a rare case of an infective endocarditis by Aerococcus spp in a bioprosthetic aortic valve following a prostate biopsy, in an asymptomatic adult with no additional risk factor for prostate cancer, excepting for age. The diagnosis was based on the presence of vegetations on the bioprosthesis seen on the echocardiogram, positive blood cultures and fever, and a favorable clinical outcome following the treatment with ceftriaxone and gentamicin.PMID:33787738 | PMC:PMC7997663 | DOI:10.1590/S1678-9946202163018 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Marcelo Ant ônio Oliveira Santos-Veloso Maria das Neves Dantas da Silveira Barros Marcos Holmes Carvalho Daniela Azevedo de Carvalho Kamel Barbosa Jorge Vieira Rodrigues Source Type: research

Molecular characterization of mutations associated with resistance to second line drugs in Mycobacterium tuberculosis patients from Casablanca, Morocco
This study is very informative and provides data on the alarming rate of fluoroquinolone resistance which warrants the need to implement appropriate drug regimens to prevent the emergence and spread of more severe forms of Mycobacterium tuberculosis drug resistance.PMID:33787739 | PMC:PMC7997671 | DOI:10.1590/S1678-9946202163019 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Ghizlane Momen Aainouss Achraf Lamaammal Abdelmajid Chetioui Fouad Blaghen Mohamed Messaoudi Malika Belghmi Khalid Mouslim Jamal El Mzibri Mohammed El Messaoudi My Driss Khyatti Meriem Chaoui Imane Source Type: research

Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit
In conclusion, we found that C. parapsilosis was the main pathogen among the NCAC candidemia in the ICU patients. APACHE II scores, central venous catheterization and the use of broad-spectrum antibiotics were independent risk factors for the occurrence of C. parapsilosis candidemia, which may provide data to support the early introduction of anti-fungal therapy.PMID:33787740 | PMC:PMC7997672 | DOI:10.1590/S1678-9946202163020 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Xiao-Shu Zuo Yanan Liu Ke Hu Source Type: research

Spatiotemporal dynamics and risk estimates of COVID-19 epidemic in Minas Gerais State: analysis of an expanding process
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e21. doi: 10.1590/S1678-9946202163021. eCollection 2021.ABSTRACTCOVID-19 is an infectious disease caused by the recently discovered coronavirus SARS-Cov-2. The disease became pandemic affecting many countries globally, including Brazil. Considering the expansion process and particularities during the initial stages of the epidemic, we aimed to analyze the spatial and spatiotemporal patterns of COVID-19 occurrence and to identify priority risk areas in Minas Gerais State, Southeast Brazil. An ecological study was performed considering all data from human cases of COVID-19 confirme...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Wendel Coura-Vital Diogo Tavares Cardoso Fabricio Thomaz de Oliveira Ker Fernanda do Carmo Magalh ães Juliana Maria Trindade Bezerra Ana Maria Viegas Maria Helena Franco Morais Leonardo Soares Bastos Ilka Afonso Reis Mari ângela Carneiro David Soeiro Ba Source Type: research

Isolated cutaneous lesions in paracoccidioidomycosis: a suggestive case of acquisition through cutaneous inoculation
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e22. doi: 10.1590/S1678-9946202163022. eCollection 2021.NO ABSTRACTPMID:33787742 | PMC:PMC7997668 | DOI:10.1590/S1678-9946202163022 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fernanda Brand ão Pacheco Nat ália Andressa Buss Venier Ana Laura Bueno Alice Lopes de Almeida Laura Milman Alessandra Koehler Danielle Machado Pagani Maria L úcia Scroferneker Source Type: research

Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e23. doi: 10.1590/S1678-9946202163023. eCollection 2021.ABSTRACTHuman immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fl ávia Esper Dahy Christina T G Novaes Gabriela A Bandeira La ís F Ramin Augusto C ésar Penalva de Oliveira Jerusa Smid Source Type: research

Molecular characterization of mosquitoes (Diptera: Culicidae) from the Colombian rainforest
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e24. doi: 10.1590/S1678-9946202163024. eCollection 2021.ABSTRACTA few studies have carried out the taxonomic and molecular characterization of sylvatic mosquito species in Latin America, where some species have been incriminated as vectors for arboviruses and parasites transmission. The present study reports the molecular characterization of mosquito species in the Sierra Nevada de Santa Marta, a natural ecosystem in the Northern coast of Colombia. Manual capture methods were used to collect mosquitoes, and the specimens were identified via classical taxonomy. The COI marker was ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Andrew S Mu ñoz-Gamba Katherine Laiton-Donato Erick Perdomo-Balaguera Lyda R Castro Jos é A Usme-Ciro Gabriel Parra-Henao Source Type: research

Challenges faced by health workers in the use of the directly observed treatment (DOT) for tuberculosis
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e25. doi: 10.1590/S1678-9946202163025. eCollection 2021.ABSTRACTTuberculosis is a worldwide public health problem, which, even with available treatment, continues to cause deaths worldwide. One of the obstacles to control the disease is the multifactorial difficulty of patients to adhere to treatment, in addition to the difficulty of health workers in circumventing barriers to implement strategies such as the directly observed treatment (DOT). The aim of this study is to analyze the performance and challenges faced by health workers in the use of DOT in tuberculosis. This is a de...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Simone Sardeto Valloto Dalazoana Betina Mendez Alc ântara Gabardo Rosilene Fressatti Cardoso Source Type: research

Epidemiological and genetic aspects of the largest dengue outbreak recorded in 2015 in Southeastern Brazil
In this study, characteristics of 2007 DENV epidemics were compared to the epidemiological, hematological and demographic outlines of the major outbreak of DENV1 in Marilia in 2015. DENV1 genetic diversity was assessed through capsid and pre-membrane junction encoding gene (CprM) sequencing. The results revealed circulation of DENV1 serotype from 2007 to 2015, with epidemics occurring every three-years until 2013 and then, increasing yearly. There were significant differences in hematological profiles of DENV1 patients between 2015 and 2007. CprM showed DENV1 genetic variability in 2015, contrasting with the unique sequenc...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Aline Diniz Cabral Luana Prado Rolim de Oliveira Juliana S á Teles de Oliveira Molina Andreia Moreira Dos Santos Carmo Rodrigo Buzinaro Suzuki Camila Marcondes de Oliveira Luciamare Perinetti Alves Martins Carlos Roberto Prudencio Andr é Eterovic M árc Source Type: research

Aerococcus spp infective endocarditis following a prostate biopsy: a case report
We report a rare case of an infective endocarditis by Aerococcus spp in a bioprosthetic aortic valve following a prostate biopsy, in an asymptomatic adult with no additional risk factor for prostate cancer, excepting for age. The diagnosis was based on the presence of vegetations on the bioprosthesis seen on the echocardiogram, positive blood cultures and fever, and a favorable clinical outcome following the treatment with ceftriaxone and gentamicin.PMID:33787738 | PMC:PMC7997663 | DOI:10.1590/S1678-9946202163018 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Marcelo Ant ônio Oliveira Santos-Veloso Maria das Neves Dantas da Silveira Barros Marcos Holmes Carvalho Daniela Azevedo de Carvalho Kamel Barbosa Jorge Vieira Rodrigues Source Type: research

Molecular characterization of mutations associated with resistance to second line drugs in Mycobacterium tuberculosis patients from Casablanca, Morocco
This study is very informative and provides data on the alarming rate of fluoroquinolone resistance which warrants the need to implement appropriate drug regimens to prevent the emergence and spread of more severe forms of Mycobacterium tuberculosis drug resistance.PMID:33787739 | PMC:PMC7997671 | DOI:10.1590/S1678-9946202163019 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Ghizlane Momen Aainouss Achraf Lamaammal Abdelmajid Chetioui Fouad Blaghen Mohamed Messaoudi Malika Belghmi Khalid Mouslim Jamal El Mzibri Mohammed El Messaoudi My Driss Khyatti Meriem Chaoui Imane Source Type: research

Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit
In conclusion, we found that C. parapsilosis was the main pathogen among the NCAC candidemia in the ICU patients. APACHE II scores, central venous catheterization and the use of broad-spectrum antibiotics were independent risk factors for the occurrence of C. parapsilosis candidemia, which may provide data to support the early introduction of anti-fungal therapy.PMID:33787740 | PMC:PMC7997672 | DOI:10.1590/S1678-9946202163020 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Xiao-Shu Zuo Yanan Liu Ke Hu Source Type: research

Spatiotemporal dynamics and risk estimates of COVID-19 epidemic in Minas Gerais State: analysis of an expanding process
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e21. doi: 10.1590/S1678-9946202163021. eCollection 2021.ABSTRACTCOVID-19 is an infectious disease caused by the recently discovered coronavirus SARS-Cov-2. The disease became pandemic affecting many countries globally, including Brazil. Considering the expansion process and particularities during the initial stages of the epidemic, we aimed to analyze the spatial and spatiotemporal patterns of COVID-19 occurrence and to identify priority risk areas in Minas Gerais State, Southeast Brazil. An ecological study was performed considering all data from human cases of COVID-19 confirme...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Wendel Coura-Vital Diogo Tavares Cardoso Fabricio Thomaz de Oliveira Ker Fernanda do Carmo Magalh ães Juliana Maria Trindade Bezerra Ana Maria Viegas Maria Helena Franco Morais Leonardo Soares Bastos Ilka Afonso Reis Mari ângela Carneiro David Soeiro Ba Source Type: research

Isolated cutaneous lesions in paracoccidioidomycosis: a suggestive case of acquisition through cutaneous inoculation
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e22. doi: 10.1590/S1678-9946202163022. eCollection 2021.NO ABSTRACTPMID:33787742 | PMC:PMC7997668 | DOI:10.1590/S1678-9946202163022 (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fernanda Brand ão Pacheco Nat ália Andressa Buss Venier Ana Laura Bueno Alice Lopes de Almeida Laura Milman Alessandra Koehler Danielle Machado Pagani Maria L úcia Scroferneker Source Type: research

Sporadic Creutzfeldt-Jakob disease in two clinically and virologically controlled Brazilian HIV patients who progressed rapidly to dementia: case reports and literature review
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e23. doi: 10.1590/S1678-9946202163023. eCollection 2021.ABSTRACTHuman immunodeficiency virus (HIV)-associated neurocognitive disorders are the main cause of cognitive decline and dementia in people living with HIV (PLHIV). However, extensive workup should be done in patients with rapidly progressive dementia (RPD) and HIV, especially when secondary infection in the central nervous system (CNS) is ruled out. Sporadic Creutzfeldt-Jakob disease (sCJD) is the main cause of RPD in non-HIV patients. It is a fatal neurodegenerative condition caused by prions that mainly affects elderly ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Fl ávia Esper Dahy Christina T G Novaes Gabriela A Bandeira La ís F Ramin Augusto C ésar Penalva de Oliveira Jerusa Smid Source Type: research

Molecular characterization of mosquitoes (Diptera: Culicidae) from the Colombian rainforest
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e24. doi: 10.1590/S1678-9946202163024. eCollection 2021.ABSTRACTA few studies have carried out the taxonomic and molecular characterization of sylvatic mosquito species in Latin America, where some species have been incriminated as vectors for arboviruses and parasites transmission. The present study reports the molecular characterization of mosquito species in the Sierra Nevada de Santa Marta, a natural ecosystem in the Northern coast of Colombia. Manual capture methods were used to collect mosquitoes, and the specimens were identified via classical taxonomy. The COI marker was ...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Andrew S Mu ñoz-Gamba Katherine Laiton-Donato Erick Perdomo-Balaguera Lyda R Castro Jos é A Usme-Ciro Gabriel Parra-Henao Source Type: research

Challenges faced by health workers in the use of the directly observed treatment (DOT) for tuberculosis
Rev Inst Med Trop Sao Paulo. 2021 Mar 24;63:e25. doi: 10.1590/S1678-9946202163025. eCollection 2021.ABSTRACTTuberculosis is a worldwide public health problem, which, even with available treatment, continues to cause deaths worldwide. One of the obstacles to control the disease is the multifactorial difficulty of patients to adhere to treatment, in addition to the difficulty of health workers in circumventing barriers to implement strategies such as the directly observed treatment (DOT). The aim of this study is to analyze the performance and challenges faced by health workers in the use of DOT in tuberculosis. This is a de...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 31, 2021 Category: Tropical Medicine Authors: Simone Sardeto Valloto Dalazoana Betina Mendez Alc ântara Gabardo Rosilene Fressatti Cardoso Source Type: research