Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets

In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission. Introduction Ticks (Acari: Ixodida) are major vectors of pathogens affecting human and animal health worldwide, and consequently the focus of research for developing novel control interventions (de la Fuente, 2018). Among tick-transmitted pathogens, Anaplasma phagocytophilum (Alphaproteobacteria: Rickettsiales) is mainly transmitted by Ixodes spp. and the causative agent of human and animal anaplasmosis and tick-borne fever in small ruminants (Severo et al., 2015). Recent developments in tick genomics have advanced research using latest omics technologies for the characterization of tick-host-pathogen interactions and the identification of candidate protective antigens (de la Fuente et al., 2016c,a, 2017; Gulia-Nuss...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Conclusions Greater public education is needed about ECT, particularly in the United States. Misperceptions and lack of knowledge may hinder utilization of ECT in India, China, and the United States.
Source: The Journal of ECT - Category: Psychiatry Tags: Original Studies Source Type: research
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Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus Omicron Variant Coronavirus Risks and Safety Concerns Coronavirus (2019-nCoV) Vaccination and Immunization Names, Organizational World Health Organization Disease Rates Travel Warnings Antibodies Immune System Source Type: news
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