Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets

Conclusion Our modeling of the modulation of the tick regulome in response to A. phagocytophilum infection provided new insights into the mechanisms that target specific functions in different tick tissues. These results supported the use of network analysis for the study of regulome response to infection. Although general mechanisms affected by A. phagocytophilum infection may be conserved even between tick and human cells (de la Fuente et al., 2016b), the effect of vector-pathogen co-evolution on pathogen isolates adaptation to grow in tick cells (Alberdi et al., 2015) may result in differences between isolates in the modulation of the tick cell regulome. Future research should be directed at validating the results of the network analysis for regulomics studies and the characterization of TF-TG interactions. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new targets for the control of tick infestations and pathogen infection/transmission. Data Availability All datasets generated for this study are included in the manuscript and/or the Supplementary Files. Author Contributions MV, AE-P, AC-C, and JdlF conceived the study and designed the experiments. SA-J, PA, and MV performed the experiments. AE-P, MV, AC-C, and JdlF performed the data analysis. JdlF, SA-J, AE-P, and AC-C wrote the manus...
Source: Frontiers in Physiology - Category: Physiology Source Type: research