Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets

In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission. Introduction Ticks (Acari: Ixodida) are major vectors of pathogens affecting human and animal health worldwide, and consequently the focus of research for developing novel control interventions (de la Fuente, 2018). Among tick-transmitted pathogens, Anaplasma phagocytophilum (Alphaproteobacteria: Rickettsiales) is mainly transmitted by Ixodes spp. and the causative agent of human and animal anaplasmosis and tick-borne fever in small ruminants (Severo et al., 2015). Recent developments in tick genomics have advanced research using latest omics technologies for the characterization of tick-host-pathogen interactions and the identification of candidate protective antigens (de la Fuente et al., 2016c,a, 2017; Gulia-Nuss...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

Abstract The study aimed to investigate the effect of eukaryotic translation initiation factor 3 subunit B (EIF3B) on cell proliferation, migration, and apoptosis as well as the underlying mechanism in acute myeloid leukemia (AML). EIF3B expression was detected in AML-193, HL-60, OCI-AML2, and KG-1 cell lines and human primary bone marrow mononuclear cells (BMMC). EIF3B knockdown was realized by transfecting EIF3B ShRNA plasmids, and EIF3B knockdown and WNT2 overexpression were established by transfecting EIF3B ShRNA plasmids and WNT2 overexpression plasmids into KG-1 cells. The effect of EIF3B knockdown, and EIF3...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
The number of new cases of a coronavirus in China fell slightly on Sunday, more than three weeks after the outbreak's epicenter was locked down, and a Chinese tourist died from the virus in France, the first fatality in Europe.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Passengers and crew members quarantined off Japan were told by the American Embassy that a chartered flight would arrive on Sunday to take them back to the United States.
Source: NYT Health - Category: Consumer Health News Tags: Coronavirus (2019-nCoV) Quarantines China Hubei Province (China) Japan Beijing (China) Epidemics Source Type: news
Publication date: Available online 14 February 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Emmanuel Rineau, Chloé Lieppe, Laurence Chausseret, Sophie Provenchere, Philippe Mauriat
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 14 February 2020Source: Materials Chemistry and PhysicsAuthor(s): Vikas V. Deshmane, Arun V. PatilThe study analyzed &interpreted variations in structural, electrical &gas sensing properties of iron oxide (n-type semiconductor) films due to the addition of cobalt oxide (p-type semiconductor). Iron Oxide was synthesized by co-precipitation method. The synthesized iron oxide and readymade cobalt oxide were mechanically mixed in various weight percentages. The screen printing method was used to prepare films. These films were characterized using XRD, SEM, EDS &static gas sensing ...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: Available online 14 February 2020Source: Materials Chemistry and PhysicsAuthor(s): Sushil S. Sangale, Vijaykumar V. Jadhav, Shoyebmohamad Shaikh, Pritamkumar V. Shinde, Balaji G. Ghule, Siddheshwar D. Raut, Mohaseen S. Tamboli, Abdullah M. Al-Enizi, Rajaram S. ManeAbstractAn alpha-iron oxide sensor (α-Fe2O3) prepared by a one-step hydrothermal synthesis technique demonstrate a high selectivity and sensitivity toward NO2 at room-temperature (27 °C). The XRD pattern of the as-synthesized sensor endows polycrystalline nature and hematite crystal structure. The gas sensing properties of α-Fe...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
CONCLUSIONS: We assessed the literature on flow cytometric immunophenotyping of AL over 3 decades as the first step toward an evidence-based analysis of the impact of this technology on the clinical management of patients with AL. PMID: 32056511 [PubMed - as supplied by publisher]
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
Publication date: Available online 15 February 2020Source: Antiviral ResearchAuthor(s): Jan Clement, Clas Ahlm, Tatjana Avšič-Županc, Jason Botten, Kartik Chandran, Colleen B. Jonsson, Hiroaki Kariwa, Jonas Klingström, Boris Klempa, Detlev H. Krüger, Herwig Leirs, Dexin Li, Mifang Liang, Alemka Markotić, Anna Papa, Connie S. Schmaljohn, Nicole D. Tischler, Rainer G. Ulrich, Antti Vaheri, Cecilia VialAbstractThe 2019 11th International Conference on Hantaviruses (ICH 2019) was organized by the International Society for Hantaviruses (ISH), and held on September 1–4, 2019, at the Irish College, in Le...
Source: Antiviral Therapy - Category: Virology Source Type: research
This study also demonstrated a decrease in the frequency and amount of BVDV in PBMCs, harvested from vaccinated calves and exposed to BVDV in vitro. Collectively data from this study highlights the association between an increase in IFN-γ and a decreased infection rate of isolated PBMC’s, based on the frequency and amount of BVDV positive cells following in vitro exposure. This new method combines not only the ability to evaluate cellular responses, but also the ability to understand potential antiviral properties associated with cellular responses. This is the first assay to describe and simultaneously measure...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Trilogy EVO Ventilator, France - Model Number: FR2110X14B Trilogy Evo is intended for pediatric through adult patients weighing at least 2.5 kg. The ventilator can measure, display, record, and alarm SpO2, FiO2, CO2, and Pulse Rate data when integrated with the appropriate accessories.
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
More News: Academia | Acinetobacter | Anaplasmosis | Antidoxidants | Babesiosis | Biology | Borrelia | Brain | Cytomegalovirus | Databases & Libraries | Dermatology | Environmental Health | France Health | Genetics | Germany Health | Grants | Iron | Leukemia | Lyme Disease | Men | Microbiology | Molecular Biology | Neurology | Neuroscience | Norway Health | Ovaries | Pakistan Health | Parasitic Diseases | Parasitology | Physiology | Reproduction Medicine | Science | Spain Health | Study | Switzerland Health | Tickborne Diseases | University of Minnesota | USA Health | Vaccines | Veterinary Research | Veterinary Vaccinations