Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets

In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission. Introduction Ticks (Acari: Ixodida) are major vectors of pathogens affecting human and animal health worldwide, and consequently the focus of research for developing novel control interventions (de la Fuente, 2018). Among tick-transmitted pathogens, Anaplasma phagocytophilum (Alphaproteobacteria: Rickettsiales) is mainly transmitted by Ixodes spp. and the causative agent of human and animal anaplasmosis and tick-borne fever in small ruminants (Severo et al., 2015). Recent developments in tick genomics have advanced research using latest omics technologies for the characterization of tick-host-pathogen interactions and the identification of candidate protective antigens (de la Fuente et al., 2016c,a, 2017; Gulia-Nuss...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

Conclusions Greater public education is needed about ECT, particularly in the United States. Misperceptions and lack of knowledge may hinder utilization of ECT in India, China, and the United States.
Source: The Journal of ECT - Category: Psychiatry Tags: Original Studies Source Type: research
While some clinicians were worried about the mandate, in the end, they're coping just fine.
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Dalton Trans., 2021, Accepted Manuscript DOI: 10.1039/D1DT03924E, PaperChristian Schneider, Lukas Guggolz, Gunnar Werncke Metal carbonyl complexes are almost exclusively found in a low-spin state due to the strong-field nature of the CO ligand. Here the characterisation of highly labile three-coordinate metal(I) monocarbonyl complexes... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Jeffrey A. SingerA Food and Drug Administration Advisory Panel justapproved, narrowly, the Merck antiviral drug Molnupiravir. This is just step one. We now have to wait for the FDA to decide on emergency use authorization.The U.K. approved Molnupiravir on November 4.Merck applied to the FDA for approval on October 11. Vaccines are the best long ‐​term defense against COVID-19, but antivirals are the best first‐​line defense, especially when new variants can develop that escape the immunity provided by vaccines.Rather than wait weeks for the vaccine to take effect, antivirals —like antibiotics—work immed...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
West Virginia's coronavirus czar, West Virginia University's Dr. Clay Marsh, said Tuesday that the emergence of the new omicron variant of Covid-19 underscores the need for everyone to be vaccinated and for the fully vaccinated to get their boosters. In a news conference with Gov. Jim Justice and other state officials, Marsh said there have been no cases of the omicron variant identified yet in West Virginia but that state officials were on alert. There also have been no cases yet identified in…
Source: Health Care News Headlines - Category: Health Management Authors: Source Type: news
CHICAGO - GE Healthcare is launching new products across a range of medica...Read more on AuntMinnie.comRelated Reading: Clinical evaluation begins on GE photon-counting CT scanner FDA clears GE Healthcare's x-ray AI for endotracheal tube placement GE to split up, creating independent GE Healthcare Protest hits GE Healthcare plant over vaccine mandate GE to expand command center software across Ore.
Source: Headlines - Category: Radiology Source Type: news
"I think it's going to be a material drop. I just don't know how much, because we need to wait for the data."WebMD Health News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
N-acetylcysteine is a promising compound for protecting cells from DNA damag...Read more on AuntMinnie.comRelated Reading: Low-dose CT works just as well as standard to diagnose appendicitis Most radiologists willing to perform PET/CT in pregnant women Body position on x-ray affects radiation dose in children Can 3D-printed shields protect patients during radiation therapy? Antioxidant formula halves DNA damage from CT
Source: Headlines - Category: Radiology Source Type: news
David J. BierThe House has now passed the Build Back Better (BBB) Act (H.R. 5376), which the Senate may or may not pass through the reconciliation process. The bill includes several important immigration-related provisions. This post will explain them in detail.Sec. 60001 – Parole and Work Permits for Long-Term ResidentsBBB would authorize (or require)[1] the Department of Homeland Security (DHS) to temporarily provide a legal status known as “parole” to any noncitizen in the United States (including both illegal immigrants and legal temporary workers and their families) who meets the bill's eligibility c...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Intense research into the new coronavirus variant first identified in southern Africa has just begun. World leaders have urged people not to panic — and to get vaccinated, if they can.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus Omicron Variant Coronavirus Risks and Safety Concerns Coronavirus (2019-nCoV) Vaccination and Immunization Names, Organizational World Health Organization Disease Rates Travel Warnings Antibodies Immune System Source Type: news
More News: Academia | Acinetobacter | Anaplasmosis | Antidoxidants | Babesiosis | Biology | Borrelia | Brain | Cytomegalovirus | Databases & Libraries | Dermatology | Environmental Health | France Health | Genetics | Germany Health | Grants | Iron | Leukemia | Lyme Disease | Men | Microbiology | Molecular Biology | Neurology | Neuroscience | Norway Health | Ovaries | Pakistan Health | Parasitic Diseases | Parasitology | Physiology | Reproduction Medicine | Science | Spain Health | Study | Switzerland Health | Tickborne Diseases | University of Minnesota | USA Health | Vaccines | Veterinary Research | Veterinary Vaccinations