Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets

In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission. Introduction Ticks (Acari: Ixodida) are major vectors of pathogens affecting human and animal health worldwide, and consequently the focus of research for developing novel control interventions (de la Fuente, 2018). Among tick-transmitted pathogens, Anaplasma phagocytophilum (Alphaproteobacteria: Rickettsiales) is mainly transmitted by Ixodes spp. and the causative agent of human and animal anaplasmosis and tick-borne fever in small ruminants (Severo et al., 2015). Recent developments in tick genomics have advanced research using latest omics technologies for the characterization of tick-host-pathogen interactions and the identification of candidate protective antigens (de la Fuente et al., 2016c,a, 2017; Gulia-Nuss...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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ConclusionThe findings declare that inhibition ofPVT1 could be a new target in the treatment of AML-M0 and help to approach more to treatments with fewer side effects.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsIn conclusion, both the venous access catheter selection algorithm and the proposed recommendations aim to respond to the needs revealed in clinical practice and to become an integrable tool in electronic prescription systems to offer homogeneous criteria for action in cancer patients that require venous access, optimizing the use of available health resources with the highest safety and quality of life for the patient.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThe implementation of what the transposition of the Directive to our legal order implies, besides the implication of the professionals, Centers and Administration, a need and a consumption of resources. If not enough are allocated, there is a risk that the innovation and improvement that the transposition would imply in order to raise the level of patient safety and the quality of Radiation Oncology in Spain will remain a paper tiger and, as the Romans said, “Non progredi est regredi”, that is, when it does not go forward, it goes backwards.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
AbstractIn this update of the consensus of the Spanish Society of Medical Oncology (Sociedad Espa ñola de Oncología Médica—SEOM) and the Spanish Society of Pathology (Sociedad Española de Anatomía Patológica—SEAP), advances in the analysis of biomarkers in advanced colorectal cancer (CRC) as well as susceptibility markers of hereditary CRC and molecular biomarkers of localized CRC are reviewed. Recently published information on the essential determination ofKRAS,NRAS andBRAF mutations and the convenience of determining the amplification of human epidermal growth factor ...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Publication date: November 2020Source: Colloid and Interface Science Communications, Volume 39Author(s): S.S. Pradhan, K. Konwar, T.N. Ghosh, B. Mondal, S.K. Sarkar, P. Deb
Source: Colloids and Interface Science Communications - Category: Nanotechnology Source Type: research
Publication date: Available online 20 September 2020Source: Materials Today: ProceedingsAuthor(s): Olumide A. Towoju, Felix A. Ishola
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 21 September 2020Source: Molecular and Cellular NeuroscienceAuthor(s): A.M. Thompson, K. Farmer, E.K. Rowe, S.P. Hayley
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: The 2010 SPILF-AFSSAPS guiding criteria for Streptococcus pneumoniae CAP are found in very variable proportions and do not, in their current form, make it possible to accurately guide towards a pneumococcal etiology in patients included in the PACSCAN study. PMID: 32950610 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Authors: MacDonald-Ramos K, Michán L, Martínez-Ibarra A, Cerbón M Abstract Silymarin is obtained from the Milk thistle plant Silybum marianum and has been used over the centuries to treat principally liver disease, although it has also been studied for its beneficial effects in cardioprotection, neuroprotection, immune modulation, and cancer among others. Importantly, silymarin's active component silybin is a flavonolignan that exhibits different activities such as; scavenger, anti-oxidant, anti-inflammatory, and recently revealed, insulin-sensitizing properties which have been explored in clin...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Publication date: Available online 20 September 2020Source: Computational and Structural Biotechnology JournalAuthor(s): Meng Wang, Jiazhen Gong, Navreet K. Bhullar
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
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