High Expression of DEPDC1 Promotes Malignant Phenotypes of Breast Cancer Cells and Predicts Poor Prognosis in Patients With Breast Cancer

In this study, the immunohistochemistry results demonstrated that DEPDC1 was high-expressed in breast cancer tissues compared with the paired adjacent normal breast tissues, and its tendency at protein level was consistent with mRNA level from TCGA data. Moreover, DEPDC1 mRNA level revealed the strongest association with poor prognosis and development in breast cancer. In vitro assays showed that DEPDC1 overexpression resulted in significant promotion of proliferation by regulating cell cycle in MCF-7 cells, whilst an opposite effect was found in the MDA-MB-231 cells with DEPDC1 deletion. Notably, further investigation indicated DEPDC1's ability of promoting breast cancer cells migration and invasion. In addition, we discovered that DEPDC1 caused hyper-activation of PI3K/AKT/mTOR signaling in breast cancer cells. Therefore, the increased DEPDC1 expression in breast cancer is correlated with disease progression and poor survival, which suggested that DEPDC1 might be a potential therapeutic target against this disease. Introduction Breast cancer is the most common carcinoma and estimated to have the highest cancer incidence rate among woman in the world (1). Radical mastectomy and chemotherapy are effective for ~85–90% patients with localized breast cancer, with a 5-years overall survival (2). However, over 30% of patients with breast carcinoma develop local invasion and distant metastasis during progression of their disease, leading to high mortality rate (...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Authors: Turan AS, Ultee G, Van Geenen EJM, Siersema PD Abstract INTRODUCTION: The most commonly used treatment for advanced colorectal adenomas is endoscopic mucosal resection (EMR). The increased number of EMRs since the introduction of the screening program for colorectal cancer has resulted in an increase in EMR-related complications. This review summarizes the current knowledge for the use of clips for the treatment and prevention of complications after EMR. Areas covered: The historical development of clips is summarized and their properties are evaluated. An overview is presented of the evidence for therapeu...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
In this study, different acidic (V2O5, ZrO2, TiO2) and basic (CaO, MgO) oxides supported copper-zinc bimetallic catalyst were prepared by deposition-precipitation method and evaluated for vapor phase hydrogenolysis of glycerol... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
We present herein the thermodynamic and X-ray characterisation of a novel ethyl phosphonohydroxamic acid-based Cu(II) metallacrown, predominating in solution in a broad pH range. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01506J, CommunicationYuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, Chuan Zhang Polygemcitabine nanogels assembled from DNA-like polygemcitabine undergo rapid intracellular degradation to generate active gemcitabine derivatives for enhanced cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
AbstractObjectiveTo evaluate factors associated with use of patient navigation in a prostate cancer population and identify whether navigation is associated with prolonged  time to care. Cancer patient navigation has been shown to improve access to cancer screening, diagnosis, and treatment, but little is known about patient navigation in prostate cancer care.MethodsAll men diagnosed with localized prostate cancer between 2009 and 2015 were abstracted from the MaineHealth  multi-specialty tumor registry. Regression analyses controlling for patient-, disease-, and system-level factors evaluated characteristics ass...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn conclusion, this study illustrates that the application and benefits of HS on reducing GI rectal dose endpoints and toxicities during prostate cancer RT can be reliably replicated in a community setting similar to centres participating in the randomised trial under high quality assurance trial monitoring.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionThere is a need to enhance a constant patient –HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients’ awareness of risks, having better treatment choice and acceptance, and reducing side-effects.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Distal intestinal obstruction syndrome (DIOS) is a common complication in patients with cystic fibrosis (CF) [1]. DIOS occurs in 10 to 40% of all CF-patients. The risk of developing DIOS is considered higher in the early post-transplant period due to dehydration, immobility, intake of opiates and post-operative adynamic gut [2]. Patients suffer from prolonged intestinal passage or even gastric paresis due to polymedication leading to chronic constipation long-term following lung transplant (LTX) [2].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
(copied from reddit) Hey guys, So I wanted to follow up on a previous thread I started, which discussed some obstacles and hardships I faced as an undergrad, which included losing my mom to cancer over the course of 2 years. In short, this left me broken mentally, physically, and a scar on my academic career. My GPA was significantly impacted and it decreased incredibly through those years, however, the past 3... What to do next? Graduate and kind of lost right now
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Nontraditional Students Source Type: forums
What’s up? Anyone remember me? Lmao. Anyway, been out in private practice for ten years and wanna know what books are most popular in residency these days. I should read a little more. Used to be Baby Miller and Morgan and Mikhail. Anything else become as popular?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
More News: Academia | Adenocarcinoma | Anesthesia | Anesthesiology | Bladder Cancer | Brain | Brain Cancers | Brain Tumor | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer Vaccines | Carcinoma | Carcinoma in Situ | Chemistry | Chemotherapy | China Health | Databases & Libraries | DCIS (Ductal Carcinoma in Situ) | Ductal Carcinoma | Education | France Health | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Germany Health | Glioma | Grants | Hepatocellular Carcinoma | Immunotherapy | Italy Health | Japan Health | Laboratory Medicine | Liver Cancer | Lung Cancer | Lung Transplant | Mastectomy | Milk | Molecular Biology | Myeloma | Nasopharyngeal Cancer | Neurology | Neuroscience | Orthopaedics | Penicillin | Prostate Cancer | Reproduction Medicine | Sarcomas | Science | Soft Tissue Sarcoma | Statistics | Students | Study | Taiwan Health | Universities & Medical Training | Vaccines | Women | Zinc