EB1-3 Chain of IL-35 Along With TGF- β Synergistically Regulate Anti-leishmanial Immunity

Conclusion Progressive L. donovani infection in BALB/c mice results in gradual up regulation of IL-10, TGF-β and both the subunit chains of IL-35. The loss in proinflammatory response during chronic VL is accompanied by accumulation of CD4+CD25+ and CD4+FoxP3+ T cells with TGF-β and IL-35 (EBI-3) as the key factors for subversion of anti-leishmanial immunity. A more detailed study on the role of IL-35 and the subunit chains of IL-12 family may open new insights in understanding the host-pathogen immunology that can potentially generate novel immunotherapeutic approaches. Ethics Statement The studies were performed according to the Committee for the Purpose of Control and Supervision on Experimental Animals (CPCSEA), Ministry of Environment and Forest, Govt. of India, and approved by the Animal Ethics Committee (147/1999/CPSCEA) of Indian Institute of Chemical Biology. Author Contributions MA and NA: conceptualization. MA, NA, AS, and MS: methodology. MA, MS, AS, MK, SD, and ND: investigation. MA, AS, and NA: writing—original draft. MA, MS, AS, MK, and NA: writing—review and editing. NA: funding acquisition, resources, and supervision. Funding This work has been supported by Council of Scientific and Industrial Research-BSC 0114, Indian Council of Medical Research and University Grant Commission, Government of India. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research