Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children

Author Affiliations open 1Unit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2International Center for Diarrheal Disease Research, Dhaka, Bangladesh PDF Version (802 KB) Abstract About This Article Supplemental Material Background: Hair is a commonly used exposure biomarker for metals and other trace elements, but concern has been raised regarding its appropriateness for assessing the internal dose. Objectives: The aim of the present study was to evaluate children’s hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and essential elements (Mg, Ca, Fe, Co, Cu, Zn, Se, Mo). Methods: In 207 children (9–10 years of age), originating from a population-based cohort in rural Bangladesh, we measured concentrations of the selected elements in hair (2 cm closest to the scalp) using ICP-MS. We compared these with previously measured concentrations in erythrocytes, urine, and water. For a subset of children (n=19), we analyzed four consecutive 2 cm pieces of hair. Results: There were strong associations between hair As and the other biomarkers (erythrocytes: rs=0.73, p
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Conclusion: Results suggest that these strains represent a putative new subgroup of BRSV with mutations observed in the immunodominant region of the G protein. However, further studies on these Brazilian BRSV strains should be performed to establish their pathogenic potential. PMID: 32083983 [PubMed - as supplied by publisher]
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Sarah Novotny, Nicole Lee-Plenty, Kedra Wallace, Wondwosen Kassahun-Yimer, Aswathi Jayaram, James A. Bofill, James N. MartinAbstractObjectiveTo determine the prevalence of acute kidney injury (AKI), placental abruption and postpartum hemorrhage in patients with preeclampsia or HELLP syndrome.Study designA retrospective study of patients with preeclampsia or HELLP syndrome treated at the University of Mississippi Medical Center from January 2000 through December 2010.Main outcome measuresRelationships among the obstetric complications of place...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Laura A Magee, Joel Singer, Terry Lee, Richard J McManus, Sarah Lay-Flurrie, Evelyne Rey, Lucy C Chappell, Jenny Myers, Alexander G Logan, Peter von DadelszenAbstractObjectiveTo examine the relationship between pregnancy outcomes and BP level and variability.DesignSecondary analysis of CHIPS trial data (Control of Hypertension In Pregnancy Study, NCT01192412).SettingInternational.Population or sampleWomen with chronic or gestational hypertension.MethodsBP measurement was standardised in outpatient clinics. Adjusted (including for allocated gr...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Cecilia Villalain, Ignacio Herraiz, Borja Cantero, Soledad Quezada, Ana Lopez, Elisa Simón, Alberto GalindoAbstractObjectivesThe optimal timing for delivery in non-severe late-preterm (34 + 0–36 + 6 weeks) preeclampsia (PE) is uncertain. It is attempted to reach term pregnancy safely but current clinical and analytical parameters fail to determine which cases will develop severe features that require preterm delivery. We aim to establish if angiogenic biomarkers may identify cases that would benefit from ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Mohamed Rezk
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
In conclusion, our data suggests that progression to kidney disease might not be a major concern in women after preeclampsia within 18 years postpartum.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Zain Awamleh, Victor K.M. HanAbstractPreeclampsia (PE) and intrauterine growth restriction (IUGR) are pregnancy complications resulting from abnormal placental development. As epigenetic regulators, microRNAs can regulate placental development and contribute to the disease pathophysiology by influencing the expression of genes involved in placental development or disease. Our previous study revealed an increase in miR-210-5p expression in placentae from patients with early-onset pregnancy complications and identified candidate gene targets fo...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
ConclusionWe feel these data are suggestive of increased on-aspirin platelet (re-)activity, as measured by the PFA-200 and the VerifyNow, in non-pregnant carriers of a FII-mutation, but not in carriers of FVL-mutation. Interestingly, this increased on-aspirin platelet (re-)activity is present in spite of low sTxB2 levels.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Author Affiliations open 1Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China 2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA 3Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA 4Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA 5Department of Biostatistics, Harvard T.H. Chan School of Public Hea...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
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