Finding A Cure Wouldn’t Mean We’ve Defeated Cancer

WebMD wasn't a research option when Ivy Brown was diagnosed with Hodgkin's lymphoma in 1974, so her mother looked up her 12-year-old daughter's condition the old-fashioned way, in a hardcover medical volume. "It just said 'fatal,'" Brown explained. Having moved the family to London a month earlier, Brown's parents were still trying to liaise with her pediatrician in the U.S. "My father told me recently that he was sleeping with the phone on his stomach because of the time change," she said. "They were as scared as you can be when you have a child who you think you might lose," Brown explained. "It was devastating for them." Robin Glassman was also 12 when she was diagnosed with Hodgkin's in 1972. Her mother wouldn't let her read the disease's description.  While the prognosis for Hodgkin's, an immune system cancer, is excellent -- it's considered one of the most curable cancers, with 10-year survival rates of about 80 percent -- that wasn't the case fifty years ago. In the 1960s, only 1 in 10 Hodgkin's patients were expected to survive for five years. Today, the two women are among the first generation of what's referred to as "long-term childhood cancer survivors" -- kids who were diagnosed in the 1970s and lived for at least five years after their initial diagnosis, a benchmark that their peers born just 10 years earlier would not have likely lived to reach. The women's scars are shown here in powerful ph...
Source: Science - The Huffington Post - Category: Science Source Type: news

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It is currently recognized that in addition to the major impact of human papillomavirus (HPV) infection in females, HPV causes considerable disease in men at the genitals, anal canal, and oropharynx. Specifically, genital HPV infections may progress to genital warts and penile carcinoma. Although studies concerning the natural history of HPV infections and associated neoplasias have mainly focused on women, during the last 2 decades considerable attention has been given in further understanding these infections in men. The HIM (HPV infection in men) Study, the only prospective multicenter study of male HPV natural history,...
Source: Acta Cytologica - Category: Cytology Source Type: research
Sexual intercourse is regarded as the primary route of human papillomavirus (HPV) transmission. Reported rates of the genotype-specific genital concordance of HPV infection among heterosexual partners vary. Most studies have evaluated only male/female genital transmission, but lately, the oral region has gained interest because of a rising trend of HPV-associated oropharyngeal cancer. Risk factors for type-specific concordance have been reported as an increasing number of younger couples, persistent HPV infection, higher frequency of sexual intercourse, rising number of spouse ’s lifetime sexual partners, and sexual ...
Source: Acta Cytologica - Category: Cytology Source Type: research
Publication date: 21 February 2019Source: Cell, Volume 176, Issue 5Author(s): Shashi Gujar, John Bell, Jean-Simon DialloOncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and initiate clinically meaningful antitumor immune responses. OVs and their resultant immunological events can act at both primary and metastatic sites. Thus, OVs can be exploited for cancer gene therapies and immunotherapies alone or in combination with other interventions, including immune checkpoint blockade.
Source: Cell - Category: Cytology Source Type: research
Publication date: 21 February 2019Source: Cell, Volume 176, Issue 5Author(s): Ting Fu, Sally Coulter, Eiji Yoshihara, Tae Gyu Oh, Sungsoon Fang, Fritz Cayabyab, Qiyun Zhu, Tong Zhang, Mathias Leblanc, Sihao Liu, Mingxiao He, Wanda Waizenegger, Emanuel Gasser, Bernd Schnabl, Annette R. Atkins, Ruth T. Yu, Rob Knight, Christopher Liddle, Michael Downes, Ronald M. EvansSummaryIncreased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant trans...
Source: Cell - Category: Cytology Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
CANCER symptoms vary depending on which part of the body is affected by a tumour. You could be at risk of deadly tumour signs if you notice this feeling in your teeth. It could be a warning sign of deadly mouth cancer. Should you see a doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Pop star-turned-vicar the Reverend Richard Coles had clinical depression at the age of 17.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Daisy Wyatt, 14, of Blackwood, Wales, finished treatment for rare bone cancer in 2016 after diagnosis at 12 years old. But the family were soon told it had spread to her lungs and was incurable.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, three non-linear indices consist of compression, one-dimensional (1D) and two-dimensional (2D) fractal dimensions are used for the determination of the malignancy or benignity of cancer tumours in breast thermograms. On the other hand, by developing the high-precision infrared cameras as well as new methods of image processing, biomedical thermography images have found a prominent position among the others. Furthermore, cancerous tissue can be affected by the laser. In this study, in order to treat the cancerous lesion identified by breast thermograms, the laser parameters are designed. The basis of controll...
Source: IET Systems Biology - Category: Biology Source Type: research
Prediction of drug synergy score is an ill-posed problem. It plays an efficient role in the medical field for inhibiting specific cancer agents. An efficient regression-based machine learning technique has an ability to minimise the drug synergy prediction errors. Therefore, in this study, an efficient machine learning technique for drug synergy prediction technique is designed by using ensemble based differential evolution (DE) for optimising the support vector machine (SVM). Because the tuning of the attributes of SVM kernel regulates the prediction precision. The ensemble based DE employs two trial vector generation tec...
Source: IET Systems Biology - Category: Biology Source Type: research
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