Fecal microbiota transplantation for Parkinson ’s disease (FMT4PD): A safety and feasibility pilot study
Background: Experimental studies suggest that fecal microbiota transplantation (FMT) may impact the pathophysiology of Parkinson ’s disease (PD) and alleviate Levodopa-induced motor complications through modulation of the gut microbiota. However, the existing data on FMT for PD is scanty. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: V.O. Chernova, K.E. Vendrik, E.M. Terveer, J.J. Keller, A.E. van der Meulen-de Jong, M.P. Bauer, J.J. van Hilten, E.J. Kuijper, J. van Prehn, M.F. Contarino Source Type: research
My Journey as a Heart Transplantation Patient …and What I Want Providers to Know-Part III
JCF is honored to share this Patient Experience Series over the next three weeks. If you have not yet read the first and second parts of this series, you can do so here (URL XXXX). Part III and final segment of the series is below. The full story will be published in the May 2024 issue and online under our Patient and Caregiver Center at www.jcfonline.com. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - May 1, 2024 Category: Cardiology Authors: Mark Booras Source Type: research
First use of the Impella 5.5 in a patient with cardiogenic shock to bridge to heart transplantation in Poland
Cardiol J. 2024;31(2):355-356. doi: 10.5603/cj.97518.NO ABSTRACTPMID:38686986 | DOI:10.5603/cj.97518 (Source: Cardiology Journal)
Source: Cardiology Journal - April 30, 2024 Category: Cardiology Authors: Roman Przybylski Miko łaj Błaziak Maciej Bochenek Anna Jarosz Barbara Barteczko-Grajek Micha ł Zakliczyński Mateusz Sokolski Mateusz Garus Piotr Gajewski Gracjan Iwanek Tomasz Skalec Krzysztof Reczuch Wiktor Kuliczkowski Source Type: research
Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
Moving from insulin substitution to the treatment of the underlying autoimmune disease in type 1 diabetes
Horm Res Paediatr. 2024 Apr 30. doi: 10.1159/000539120. Online ahead of print.ABSTRACTCurrently a paradigm change occurs in type 1 diabetes from insulin substitution to the treatment of the underlying autoimmune disease. Teplizumab, a humanized monoclonal anti CD3 antibody, is the first FDA approved disease modifying treatment of preclinical stage 2 diabetes. Research of drugs like Golimumab, a monoclonal antibody specific for TNF alpha, baricitinib, a tyrosine kinase inhibitor, or frexalimab, a monoclonal antibody against the CD40-Ligand, is still ongoing. Repurposing drugs that have been used in other indications like th...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jantje Weiskorn Thomas Danne Source Type: research
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of Renal Transplant Patients
CONCLUSIONS In addition to age, BMI, and TAC concentration after RT, antibiotic use may be a novel factor affecting PTDM. The use of antibiotics may influence the development of PTDM.PMID:38685698 | DOI:10.12659/AOT.943282 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 30, 2024 Category: Transplant Surgery Authors: Zhenwei Jiang Caomei Xu Huan Hou Xuping Yang Minyan Qian Lian Zuo Peipei Wang Qing Qian Yan Jiang Nan Hu Source Type: research
Sigle Agent of Posttransplant Cyclophosphamide Without Calcineurin Inhibitor Controls Severity of Experimental Chronic GVHD
Acta Med Okayama. 2024 Apr;78(2):123-134. doi: 10.18926/AMO/66915.ABSTRACTChronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its ...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Kyosuke Saeki Hideaki Fujiwara Keisuke Seike Taiga Kuroi Hisakazu Nishimori Takehiro Tanaka Ken-Ichi Matsuoka Nobuharu Fujii Yoshinobu Maeda Source Type: research
Long-term Outcomes of Peripheral Blood Stem Cell Unrelated Donors Mobilized with Filgrastim
Blood Adv. 2024 Apr 30:bloodadvances.2024012646. doi: 10.1182/bloodadvances.2024012646. Online ahead of print.ABSTRACTAllogeneic hematopoietic cell transplantation is a life-saving procedure used to treat of a variety of devastating diseases. It requires hematopoietic stem cells collected via filgrastim mobilized peripheral blood stem cells or bone marrow harvest from volunteer unrelated donors. There is a paucity of safety data regarding donors' long-term adverse events. This prospective, observational study combined peripheral blood stem cell donors enrolled on the NMDP Investigational New Drug trial and bone marrow dono...
Source: Adv Data - April 30, 2024 Category: Epidemiology Authors: Heather E Stefanski Michelle Kuxhausen Stephanie Bo-Subait Hati Kobusingye Deborah Mattila Jennifer Schenfeld Darcie Sandschafer Linda J Burns Bronwen E Shaw Michael A Pulsipher John P Miller Steven M Devine Source Type: research
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of t...
Source: Hematology - April 30, 2024 Category: Hematology Authors: Mariana G Meade Javier Bola ños-Meade Source Type: research
Sigle Agent of Posttransplant Cyclophosphamide Without Calcineurin Inhibitor Controls Severity of Experimental Chronic GVHD
Acta Med Okayama. 2024 Apr;78(2):123-134. doi: 10.18926/AMO/66915.ABSTRACTChronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its ...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Kyosuke Saeki Hideaki Fujiwara Keisuke Seike Taiga Kuroi Hisakazu Nishimori Takehiro Tanaka Ken-Ichi Matsuoka Nobuharu Fujii Yoshinobu Maeda Source Type: research
Clinical features of immature leukemias in children
Int J Hematol. 2024 Apr 30. doi: 10.1007/s12185-024-03771-7. Online ahead of print.ABSTRACTEarly T-cell precursor acute lymphoblastic leukemia (ETP-ALL), mixed phenotypic acute leukemia (MPAL), and acute myeloid leukemia with minimal differentiation (AML-M0) all originate from immature hematopoietic progenitor cells and have a poor prognosis. We investigated the clinical characteristics of these immature leukemias in 17 children (ETP-ALL: 8, MPAL: 5, AML-M0: 4) at seven institutions. Clinical and laboratory findings were comparable across disease types. Eleven and six patients received ALL- and AML-oriented induction chemo...
Source: International Journal of Hematology - April 30, 2024 Category: Hematology Authors: Daichi Sajiki Nao Yoshida Hideki Muramatsu Kimiyoshi Sakaguchi Naoko Maeda Norifumi Yokoyama Yuji Miyajima Makito Tanaka Yoshiyuki Takahashi Asahito Hama Source Type: research
Clinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China
Conclusion: Hypoxic/ischemic injury and infection are the predominant etiologies of NALF in China. The overall prognosis of NALF is poor, but its short-term prognosis is determined by the etiology. What is Known: • Neonatal acute liver failure (NALF) is a rare disorder with limited cohort studies, especially in China. • Gestational alloimmune liver disease, viral infections (especially herpes simplex virus), metabolic diseases and ischemic insults are common etiologies of NALF, which are significantly different from other populations. • There are no reliable biochemical markers to predict the outcome of NALF. What is...
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Suhua Xu Peng Zhang Mengmeng Ge Yuanyuan Shan Guoqiang Cheng Source Type: research
Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
First use of the Impella 5.5 in a patient with cardiogenic shock to bridge to heart transplantation in Poland
Cardiol J. 2024;31(2):355-356. doi: 10.5603/cj.97518.NO ABSTRACTPMID:38686986 | DOI:10.5603/cj.97518 (Source: Cardiology Journal)
Source: Cardiology Journal - April 30, 2024 Category: Cardiology Authors: Roman Przybylski Miko łaj Błaziak Maciej Bochenek Anna Jarosz Barbara Barteczko-Grajek Micha ł Zakliczyński Mateusz Sokolski Mateusz Garus Piotr Gajewski Gracjan Iwanek Tomasz Skalec Krzysztof Reczuch Wiktor Kuliczkowski Source Type: research
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of t...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Mariana G Meade Javier Bola ños-Meade Source Type: research
