A higher CD34 + cell dose correlates with better event-free survival after KIR-ligand mismatched cord blood transplantation for childhood acute myeloid leukemia
Although killer Ig-like receptor ligands (KIR-L) mismatch has been associated with alloreactive natural killer cell activity and potent graft-versus-leukemia (GVL) effect among adults with acute myeloid leukem... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 29, 2024 Category: Hematology Authors: Hisashi Ishida, Yuta Kawahara, Daisuke Tomizawa, Yasuhiro Okamoto, Asahito Hama, Yuko Cho, Katsuyoshi Koh, Yuhki Koga, Nao Yoshida, Maho Sato, Kiminori Terui, Naoyuki Miyagawa, Akihiro Watanabe, Junko Takita, Ryoji Kobayashi, Masaki Yamamoto & hellip; Tags: Correspondence Source Type: research
Viruses, Vol. 16, Pages 709: COVID-19 in Lung Transplant Recipients: A Report on 10 Recent Cases
oczulla
Due to immunosuppression, transplant recipients are at higher risk of infections with SARS-CoV-2 and worse clinical outcomes than immunocompetent hosts. Furthermore, lung transplant patients represent a special group among solid organ recipients, since pneumonia is the main manifestation of COVID-19. However, data on the course of disease and the changes in morbidity and mortality during the course of the pandemic are limited. In our pulmonary rehabilitation clinic, we treat patients shortly after lung transplant as well as long-term transplant patients. Over the last almost 4 years of pandemic, we witnessed se...
Source: Viruses - April 29, 2024 Category: Virology Authors: Lea Reemann Nikolaus Kneidinger Bernd Sczepanski Andreas Rembert Koczulla Tags: Case Report Source Type: research
Assessment of biological organ age using molecular pathology in pre-transplant kidney biopsies.
Organ shortage is a major challenge in kidney transplantation but the use of older donors, often with co-morbidities, is hampered by inconsistent outcomes. Methods of accurately stratifying marginal donor organs by clinical and histological assessment are lacking. To better understand organ variability, we profiled the transcriptomes of 271 kidneys from deceased donors at retrieval. Following correction for biopsy composition, we assessed molecular pathways that associated with delayed, and sub-optimal one-year graft function. (Source: Kidney International)
Source: Kidney International - April 29, 2024 Category: Urology & Nephrology Authors: Roy Zhang, Patrick B. Trotter, James McCaffrey, Rory Fitzroy, Giorgio Trivioli, Benjamin J. Stewart, John R. Ferdinand, Kevin W. Loudon, Alexandra Riding, Jonathan West, Ashley Ferro, Menna R. Clatworthy Tags: basic research Source Type: research
Prognostic Value of RV Function Analysis During the Interstage Period in Patients with Hypoplastic Left Heart Syndrome
AbstractCardiac dysfunction is associated with mortality in children with hypoplastic left heart syndrome (HLHS). We evaluated the ability of qualitative and quantitative RV functional parameters to predict outcomes in HLHS patients. In this retrospective, single-center study, echocardiograms from 3 timepoints (pre-stage 1 palliation, 4 –8 weeks post-stage 1 palliation, and pre-Glenn) were analyzed in infants with HLHS. Patients were stratified into two groups based on outcome of transplant-free survival post-Glenn (survivors) versus mortality or transplantation prior to Fontan (non-survivors). Images were retrospective...
Source: Mammalian Genome - April 28, 2024 Category: Genetics & Stem Cells Source Type: research
Potential biomarkers for immune monitoring after renal transplantation
Transpl Immunol. 2024 Apr 26:102046. doi: 10.1016/j.trim.2024.102046. Online ahead of print.ABSTRACTRenal transplantation represents the foremost efficacious approach for ameliorating end-stage renal disease. Despite the current state of advanced renal transplantation techniques and the established postoperative immunosuppression strategy, a subset of patients continues to experience immune rejection during both the early and late postoperative phases, ultimately leading to graft loss. Consequently, the identification of immunobiomarkers capable of predicting the onset of immune rejection becomes imperative in order to fac...
Source: Transplant Immunology - April 28, 2024 Category: Transplant Surgery Authors: Xiaoyu Xu Yi Chen Luyue Kong Xianduo Li Dongdong Chen Zhe Yang Jianning Wang Source Type: research
The predictors and risk factors of two-year rejection in renal transplant patients: A multicenter case-control study
CONCLUSION: Our findings emphasize the need for appropriate prevention and management of infections following kidney transplantation to avoid more serious problems, such as rejection, which could significantly raise the likelihood of allograft failure and probably death. Further studies with larger sample size are needed to investigate the impact of serum chloride levels prior to transplant and intraoperative hypotension on the risk of rejection.PMID:38679014 | DOI:10.1159/000538963 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2024 Category: Urology & Nephrology Authors: Maram M Alsulami Nouf E Al-Otaibi Walaa A Alshahrani Abdulrahman Altheaby Khalefa M Al Thiab Lina I Alnajjar Mohamed A Albekery Reem F Almutairy Mohammed Y Asiri Sumaya N AlMohareb Faisal Aqeel Alsehli Alanoud T Binthuwaini Alaa Almagthali Sarah S Alwaily Source Type: research
Parental liver transplantation for treating progressive familial intrahepatic cholestasis: A rare case report
Asian J Surg. 2024 Apr 27:S1015-9584(24)00690-0. doi: 10.1016/j.asjsur.2024.04.030. Online ahead of print.NO ABSTRACTPMID:38679553 | DOI:10.1016/j.asjsur.2024.04.030 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 28, 2024 Category: Surgery Authors: Ding-Yuan Wan Wei Lai Min He Zhong-Wei Zhang Source Type: research
Temporarily Reversing Warfarin With Low-Dose 4-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Patients Undergoing an Invasive Procedure
CONCLUSIONS AND RELEVANCE: Low-dose PCC4 appears to be a safe and effective temporary reversal strategy for patients with LVADs undergoing low-bleed risk elective procedures.PMID:38678311 | DOI:10.1177/10600280241248172 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 28, 2024 Category: Drugs & Pharmacology Authors: Byron Stevenson A Joshua Roberts William E Dager Source Type: research
Current status and new experimental diagnostic methods of invasive fungal infections after hematopoietic stem cell transplantation
Arch Microbiol. 2024 Apr 28;206(5):237. doi: 10.1007/s00203-024-03905-9.ABSTRACTInvasive fungal infections (IFIs) are common and life-threatening complications in post-hematopoietic stem cell transplantation (post-HSCT) recipients, Severe IFIs can lead to systemic infection and organ damage, which results in high mortality in HSCT recipients. With the development of the field of fungal infection diagnosis, more and more advanced non-culture diagnostic tools have been developed, such as glip biosensors, metagenomic next-generation sequencing, Magnetic Nanoparticles and Identified Using SERS via AgNPs+ , and artificial intel...
Source: Archives of Microbiology - April 28, 2024 Category: Microbiology Authors: Zhenhua Tang HaiTao Wang Yuankai Liu Chen Wang Xinye Li Qiong Yang Source Type: research
Potential biomarkers for immune monitoring after renal transplantation
Transpl Immunol. 2024 Apr 26:102046. doi: 10.1016/j.trim.2024.102046. Online ahead of print.ABSTRACTRenal transplantation represents the foremost efficacious approach for ameliorating end-stage renal disease. Despite the current state of advanced renal transplantation techniques and the established postoperative immunosuppression strategy, a subset of patients continues to experience immune rejection during both the early and late postoperative phases, ultimately leading to graft loss. Consequently, the identification of immunobiomarkers capable of predicting the onset of immune rejection becomes imperative in order to fac...
Source: Transplant Immunology - April 28, 2024 Category: Transplant Surgery Authors: Xiaoyu Xu Yi Chen Luyue Kong Xianduo Li Dongdong Chen Zhe Yang Jianning Wang Source Type: research
Parental liver transplantation for treating progressive familial intrahepatic cholestasis: A rare case report
Asian J Surg. 2024 Apr 27:S1015-9584(24)00690-0. doi: 10.1016/j.asjsur.2024.04.030. Online ahead of print.NO ABSTRACTPMID:38679553 | DOI:10.1016/j.asjsur.2024.04.030 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 28, 2024 Category: Surgery Authors: Ding-Yuan Wan Wei Lai Min He Zhong-Wei Zhang Source Type: research
The predictors and risk factors of two-year rejection in renal transplant patients: A multicenter case-control study
CONCLUSION: Our findings emphasize the need for appropriate prevention and management of infections following kidney transplantation to avoid more serious problems, such as rejection, which could significantly raise the likelihood of allograft failure and probably death. Further studies with larger sample size are needed to investigate the impact of serum chloride levels prior to transplant and intraoperative hypotension on the risk of rejection.PMID:38679014 | DOI:10.1159/000538963 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - April 28, 2024 Category: Urology & Nephrology Authors: Maram M Alsulami Nouf E Al-Otaibi Walaa A Alshahrani Abdulrahman Altheaby Khalefa M Al Thiab Lina I Alnajjar Mohamed A Albekery Reem F Almutairy Mohammed Y Asiri Sumaya N AlMohareb Faisal Aqeel Alsehli Alanoud T Binthuwaini Alaa Almagthali Sarah S Alwaily Source Type: research
Temporarily Reversing Warfarin With Low-Dose 4-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Patients Undergoing an Invasive Procedure
CONCLUSIONS AND RELEVANCE: Low-dose PCC4 appears to be a safe and effective temporary reversal strategy for patients with LVADs undergoing low-bleed risk elective procedures.PMID:38678311 | DOI:10.1177/10600280241248172 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 28, 2024 Category: Drugs & Pharmacology Authors: Byron Stevenson A Joshua Roberts William E Dager Source Type: research
Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damage
CONCLUSIONS: Collectively, we demonstrate that our in vitro co-culture system is a new valuable tool to facilitate the investigation of the molecular mechanisms behind the therapeutic effects of MSCs on damaged intestinal epithelium. This could benefit further optimization of the use of MSCs in HSCT patients.PMID:38679715 | DOI:10.1186/s13287-024-03738-9 (Source: Cell Research)
Source: Cell Research - April 28, 2024 Category: Cytology Authors: B Yetkin-Arik S A Jansen S Varderidou-Minasian B Westendorp K-P Skarp M Altelaar C A Lindemans M J Lorenowicz Source Type: research
Safety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study
CONCLUSION: Intravenous transplantation of HUC-MSCs is a safe and effective therapeutic approach on aging frailty. The positive outcomes observed in improving quality of life, physical performance, and reducing chronic inflammation, suggest that HUC-MSC therapy may be a promising potential treatment option for aging frailty.TRIAL REGISTRATION: Clinicaltrial.gov; NCT04314011; https://clinicaltrials.gov/ct2/show/NCT04314011 .PMID:38679727 | DOI:10.1186/s13287-024-03707-2 (Source: Cell Research)
Source: Cell Research - April 28, 2024 Category: Cytology Authors: Yingqian Zhu Ce Huang Liang Zheng Qingqing Li Jianli Ge ShaSha Geng Miaomiao Zhai Xin Chen Huixiao Yuan Yang Li Wenwen Jia Keping Sun Yan Li Tong Ye Zhengmei Zhao Hailiang Liu Zhongmin Liu Hua Jiang Source Type: research
