Variables Prevalent Among Early Unplanned Readmissions in Infants Following Congenital Heart Surgery
AbstractMedically complex children including infants undergoing cardiac surgery are at increased risk for hospital readmissions. Investigation of this population may reveal opportunities to optimize systems and coordination of care. A retrospective study of all infants undergoing cardiac surgery from 2015 through 2016 at a large tertiary institution who were readmitted within 1 year of discharge from cardiac surgical hospitalization was performed. Data specific to patient characteristics, surgical hospitalization, and readmission hospitalization are described. Unplanned readmissions within 1 year of hospital discharge were...
Source: Mammalian Genome - May 11, 2021 Category: Genetics & Stem Cells Source Type: research

Utility of Surveillance Ambulatory Rhythm Monitoring in the Pediatric Fontan Population
AbstractOur institution established a Fontan surveillance plan, which included ambulatory rhythm monitoring (ARM) at 6, 10, 13, 16 and 19 years old, for early detection of Fontan-associated complications. We conducted a retrospective chart review of Fontan patients followed at our institution 2014 –2018 to determine the utility of surveillance ARMs. 139 ARMs from 83 patients were included. ARMs with supraventricular tachycardia, sinus node dysfunction, accelerated junctional rhythm, >  1st degree atrioventricular block, and complex ventricular ectopy were classified as positive for arrhythmia. Arrhyt...
Source: Mammalian Genome - May 7, 2021 Category: Genetics & Stem Cells Source Type: research

Outcomes of Surgical Repair of Total Anomalous Pulmonary Venous Drainage: Role of Primary Sutureless Technique
AbstractTo evaluate the surgical outcomes of total anomalous pulmonary venous drainage focusing on survival, postoperative and pulmonary venous obstruction. Further investigate the role of primary sutureless technique in patients with preoperative pulmonary venous obstruction. Consecutive patients underwent total anomalous pulmonary venous drainage repair in our institution during Jan 2000 to Dec 2019 were enrolled into this retrospective analysis. Since 2016, sutureless repair was regularly applied in patients with preoperative pulmonary venous obstruction. All patients with preoperative pulmonary venous obstruction refer...
Source: Mammalian Genome - May 3, 2021 Category: Genetics & Stem Cells Source Type: research

Finding the Optimal Timing for Repair of Standard Tetralogy of Fallot: Analysis of Cardiac Magnetic Resonance and Echocardiography Parameters Related to Intermediate Term Outcomes in a Pediatric Population
ConclusionsAlthough all patients from our cohort had significant PR, age at surgery was not related to RV or pulmonary trunk dilatation. Previous palliative surgery was associated with more severe right ventricular dilatation and longer hospital stays. No differences were observed between early and late repair groups. Our study suggests that postponing TOF repair to a late stage does not improve the degree of PR or long-term morbidity from RV dilatation. Palliative surgery should be avoided if possible. (Source: Mammalian Genome)
Source: Mammalian Genome - May 2, 2021 Category: Genetics & Stem Cells Source Type: research

Health-Related Quality of Life in Pediatric Cardiac Patients After Extracorporeal Life Support
AbstractExtracorporeal Life Support (ECLS) is often considered successful if the child leaves intensive care alive. For the child and family, a major concern is quality of life. Aim of this study is to compare health-related quality of life scores of children following cardiac ECLS to a healthy control group. Cross-sectional prospective study using Pediatric Quality of Life Inventory 4.0 Generic Core Scale questionnaire. Population included consecutive children between two and sixteen years of age who underwent cardiac ECLS from 2005 to 2016 and their parents. Each age groups ’ mean and standard deviation was analyze...
Source: Mammalian Genome - April 30, 2021 Category: Genetics & Stem Cells Source Type: research

Left Ventricular Torsion Obtained Using Equilibrated Warping in Patients with Repaired Tetralogy of Fallot
AbstractPatients after surgical repair of Tetralogy of Fallot (rTOF) may suffer a decrease in left ventricular (LV) function. The aim of our study is to evaluate a novel method of assessing LV torsion in patients with rTOF, as an early indicator of systolic LV dysfunction. Motion tracking based on image registration regularized by the equilibrium gap principle, known as equilibrated warping, was employed to assess LV torsion. Seventy-six cases of rTOF and ten normal controls were included. The group of controls was assessed for reproducibility using both equilibrated warping and standard clinical tissue tracking software (...
Source: Mammalian Genome - April 26, 2021 Category: Genetics & Stem Cells Source Type: research

Changes in Sedation Practices in Association with Delirium Screening in Infants After Cardiopulmonary Bypass
AbstractSedation in the cardiac intensive care unit (CICU) is necessary to keep critically ill infants safe and comfortable. However, long-term use of sedatives may be associated with adverse neurodevelopmental outcomes. We aimed to examine sedation practices in the CICU after the implementation of the Cornell Assessment of Pediatric Delirium (CAPD). We hypothesize the use of the CAPD would be associated with a decrease in sedative weans at CICU discharge. This is a single institution, retrospective cohort study. The study inclusion criteria were term infants, birthweight  >  2.5 kg, cardiopulmonary b...
Source: Mammalian Genome - April 23, 2021 Category: Genetics & Stem Cells Source Type: research

Inter-observer and Inter-vendor Variability in Strain Measurements in Patients with Single Right Ventricular Anatomy
AbstractMyocardial strain offers new insights into ventricular performance, There are software packages from several different companies used to ascertain this, and little data is available in patients with single right ventricle (sRV) physiology. We aimed to compare the analysis of two strain software applications using a cohort of patients with sRV for both inter-vendor and inter-observer variability. Echocardiograms from 85 patients with sRV (122 separate studies) were prospectively evaluated. All had Glenn and/or Fontan palliation. Longitudinal 4-chamber (4LS), inflow/outflow (IO), circumferential, and radial strain we...
Source: Mammalian Genome - April 23, 2021 Category: Genetics & Stem Cells Source Type: research

Causes of Death in Infants and Children with Congenital Heart Disease
AbstractWith improved surgical outcomes, infants and children with congenital heart disease (CHD) may die from other causes of death (COD) other than CHD. We sought to describe the COD in youth with CHD in North Carolina (NC). Patients from birth to 20  years of age with a healthcare encounter between 2008 and 2013 in NC were identified by ICD-9 code. Patients who could be linked to a NC death certificate between 2008 and 2016 were included. Patients were divided by CHD subtypes (severe, shunt, valve, other). COD was compared between groups. Reco rds of 35,542 patients 
Source: Mammalian Genome - April 22, 2021 Category: Genetics & Stem Cells Source Type: research

Height Versus Body Surface Area to Normalize Cardiovascular Measurements in Children Using the Pediatric Heart Network Echocardiographic Z-Score Database
Abstract Normalizing cardiovascular measurements for body size allows for comparison among children of different ages and for distinguishing pathologic changes from normal physiologic growth. Because of growing interest to use height for normalization, the aim of this study was to develop height-based normalization models and compare them to body surface area (BSA)-based normalization for aortic and left ventricular (LV) measurements. The study population consisted of healthy, non-obese children between 2 and 18  years of age enrolled in the Pediatric Heart Network Echo Z-Score Project. The echocardiographic study p...
Source: Mammalian Genome - April 20, 2021 Category: Genetics & Stem Cells Source Type: research

Does Maintenance of Pulmonary Blood Flow Pulsatility at the Time of the Fontan Operation Improve Hemodynamic Outcome in Functionally Univentricular Hearts?
AbstractIt is unclear whether residual anterograde pulmonary blood flow (APBF) at the time of Fontan is beneficial. Pulsatile pulmonary flow may be important in maintaining a compliant and healthy vascular circuit. We, therefore, wished to ascertain whether there was hemodynamic evidence that residual pulsatile flow at time of Fontan promotes clinical benefit. 106 consecutive children with Fontan completion (1999 –2018) were included. Pulmonary artery pulsatility index (PI, (systolic pressure–diastolic pressure)/mean pressure)) was calculated from preoperative cardiac catheterization. Spectral analysis charted ...
Source: Mammalian Genome - April 19, 2021 Category: Genetics & Stem Cells Source Type: research

Hypoplastic Left Heart: Stage-I Will be Performed Interventionally, Soon
AbstractThe hypoplasia of left-sided heart structures shows great variability and complexity. What the many variants have in common is that their heart structures are neither fully developed before nor after birth. Fetuses and newborns require an individual therapy depending on anatomy and function of the heart. Fetal interventions focus on improving left heart structures by catheter-based interventions and maternal hyperoxygenation which promotes growth as the left ventricular preload and blood flow within the cavity increase. Stage-I management of newborns with single ventricle physiology is usually based on the Norwood/...
Source: Mammalian Genome - April 19, 2021 Category: Genetics & Stem Cells Source Type: research

Recurrent Extubation Failure Following Neonatal Cardiac Surgery Is Associated with Increased Mortality
This study confirmed that patients with recurrent EF have a high morality. Neonates with a cardiovascular reason for first-time EF are more likely to have a recurrent EF than those with other causes . (Source: Mammalian Genome)
Source: Mammalian Genome - April 17, 2021 Category: Genetics & Stem Cells Source Type: research

American College of Cardiology Body Mass Index Counseling Quality Improvement Initiative
AbstractOverweight/obesity, prevalent cardiovascular risk factors in children, can be associated with increased risk of adverse outcomes in children with heart disease. The American College of Cardiology (ACC) developed quality metrics including a BMI metric related to identifying and counseling overweight and obese children presenting to cardiology clinics. This metric was used for a multicenter collaborative learning Quality improvement (QI) Project through the ACC Quality Network (QNet). Our aim was to increase the percentage of children between ages 3 and 18  years presenting to cardiology clinics at participating...
Source: Mammalian Genome - April 15, 2021 Category: Genetics & Stem Cells Source Type: research

Deciphering Genetic Variants of Warfarin Metabolism in Children With Ventricular Assist Devices
The objectives of this study were to evaluate the prevalence ofCY2CP9 1*2*3*,VKORC1, andCYP4F2 in children with VADs and the time to reach the target international normalized ratio. We performed a retrospective/prospective study in children with VADs. We recorded polymorphisms, disease, type of VAD, ethnicity, age, gender, height, weight, INR values, bleeding, and thromboembolic episodes. Informed consent was obtained. We enrolled 34 children (19 male, 15 female), with a median age of 2  years (range 0.3–17 years) and median weight of 6.9Kg. The Berlin Heart was the most commonly implanted VAD (22/34; 64%),...
Source: Mammalian Genome - April 10, 2021 Category: Genetics & Stem Cells Source Type: research

High Acuity Therapy Variation Across Pediatric Acute Care Cardiology Units: Results from the Pediatric Acute Care Cardiology Collaborative Hospital Surveys
AbstractWe utilized the multicenter Pediatric Acute Care Cardiology Collaborative (PAC3) 2017 and 2019 surveys to describe practice variation in therapy availability and changes over a 2-year period. A high acuity therapies (ATs) score was derived (1 point per positive response) from 44 survey questions and scores were compared to center surgical volume. Of 31 centers that completed the 2017 survey, 26 also completed the 2019 survey. Scores ranged from 11 to 34 in 2017 and 11 to 35 in 2019. AT scores in 2019 were not statistically different from 2017 scores (29/44, IQR 27 –32.5 vs. 29.5/44, IQR 27–31,p =...
Source: Mammalian Genome - April 4, 2021 Category: Genetics & Stem Cells Source Type: research

Measurement of Left Ventricular Dimensions and Ejection Fraction in Neonates by Three-Dimensional Echocardiography: A Comparative Study Between Philips QLAB and TOMTEC Software —Are the Values Interchangeable?
AbstractThree-dimensional echocardiography is being used to evaluate left ventricular dimensions and ejection fraction in clinical practice. The validity and normal values have been established in a large group of normal adults, children and neonates. The aim of this study was to compare left ventricular dimensions and ejection fraction obtained from the same 3-dimensional echocardiography datasets using 2 commercially available applications: Philips QLAB and Tomtec 4D LEFT VENTRICLE-ANALYSIS. Fifty consecutive newborns or neonates coming to their first newborn visit within the first 3  weeks of live, were recruited. ...
Source: Mammalian Genome - March 31, 2021 Category: Genetics & Stem Cells Source Type: research

Left Atrial Strain in the Repaired Tetralogy of Fallot Population: Comparisons to Biventricular Function, Native T1 Values, Exercise Parameters and Healthy Controls
AbstractBackgroundNon-invasive imaging markers in patients with repaired tetralogy of Fallot (rTOF) are still being investigated to inform clinical decision making. Atrial function is a prognostic indicator in many acquired and congenital heart diseases. We sought to examine the relationship between cardiac MRI (CMR)-derived indices of left atrial (LA) function, native left ventricular (LV) T1 values, biventricular systolic function, and exercise capacity in rTOF.MethodsSixty-six patients with rTOF without prior pulmonary valve replacement who underwent CMR (median age 18.5  years) were identified. Twenty-one adult rT...
Source: Mammalian Genome - March 28, 2021 Category: Genetics & Stem Cells Source Type: research

Congenital Heart Disease in Syrian Refugee Children: The Experience at a Tertiary Care Center in a Developing Country
This study aims to describe the presentations, diagnoses, management, financial burden, and outcomes among Syrian refugees with congenital heart disease (CHD) in Lebanon. This is a retrospective study that was conducted through reviewing the charts of all Syrian pediatric patients referred to the Children ’s Heart Center at the American University of Beirut Medical Center for evaluation between the years 2012 and 2017. We reviewed the charts of 439 patients. The mean age at presentation was 3.97 years, and 205 patients (46.7%) were females. 99 Patients (22.6%) were found to have no heart disease, 69 (15.7%) had ...
Source: Mammalian Genome - March 18, 2021 Category: Genetics & Stem Cells Source Type: research

A Fetal Presentation of a Ruptured Right Ventricular Diverticulum
We present a case of a ruptured diverticulum in a fetus and the clinical course. (Source: Mammalian Genome)
Source: Mammalian Genome - March 16, 2021 Category: Genetics & Stem Cells Source Type: research

Upcoming Events in Pediatric Cardiology Pediatric Cardiology 42-2
(Source: Mammalian Genome)
Source: Mammalian Genome - March 13, 2021 Category: Genetics & Stem Cells Source Type: research

Long-term Incidence of Kawasaki Disease in a North American Community: A Population-Based Study
AbstractTo assess the longitudinal incidence of Kawasaki disease (KD) within the well-defined predominantly White population of Olmsted County, MN. This retrospective cohort study used a population-based medical record linkage system and manual chart reviews to identify children with KD in Olmsted County, MN between January 1, 1979-December 31, 2016. Age- and gender-adjusted incidence rates were calculated using the 2010 U.S. White population. 124 children with KD were confirmed during the study period (median age 3.5, 61% male, 85% White, 9% Asian). The overall age- and gender-adjusted incidence rates for all ages and  
Source: Mammalian Genome - March 12, 2021 Category: Genetics & Stem Cells Source Type: research

Ventriculotomy Decreases Agreement Between Assessment of Right Ventricular Function by Echocardiography and Cardiac Magnetic Resonance Imaging in Patients with Hypoplastic Left Heart Syndrome
AbstractAccurate assessment of the right ventricular (RV) volume and function is important in patients with hypoplastic left heart syndrome (HLHS). We sought to investigate the effect of ventriculotomy on the correlation of RV functional assessments by two-dimensional echocardiography (2DE) to cardiac magnetic resonance (CMR)-derived RV ejection fraction (EF) in patients with HLHS. A retrospective re-analysis of CMR imaging with matched 2DE was performed from the institutional HLHS registry. Echocardiographic RV functional parameters were analyzed and correlated with CMR-derived EF. Intraclass correlation coefficient was u...
Source: Mammalian Genome - March 9, 2021 Category: Genetics & Stem Cells Source Type: research

Making the Match: Three Program Directors ’ Thoughts on Successfully Matching into Pediatric Cardiology Fellowship
AbstractSuccessfully matching into a pediatric cardiology fellowship program is difficult, and there is currently a paucity of helpful material for prospective applicants. To address this gap and to guide pediatric cardiology fellowship applicants in navigating this process, three fellowship program directors have compiled a list of recommendations on how residents can improve their chances for a successful match. Detailed descriptions of the following recommendations are provided:become a great pediatrician, show consistent interest in pediatric cardiology, complete a research project, ensure great letters of recommendati...
Source: Mammalian Genome - March 5, 2021 Category: Genetics & Stem Cells Source Type: research

Clinical Outcome of Patients with Transposition of the Great Arteries and Intramural Coronary Artery
AbstractTo review the early and intermediate outcomes of patients with transposition of the great arteries (TGA) and intramural coronary artery (IMCA) who underwent arterial switch operation (ASO) at our center. Among 450 patients with TGA who underwent an ASO between 2010 and 2018, 26 (5.8%) patients were identified with IMCA. The left coronary artery was intramural in 21 of 26 patients. We adopted coronary transfer using double coronary buttons with unroofed intramural course for all 26 patients. Early mortality for patients with IMCA was 3 of 26 (11.5%) compared with 10 of 424 (2.4%) for those without IMCA (p =&t...
Source: Mammalian Genome - February 16, 2021 Category: Genetics & Stem Cells Source Type: research

Correction to: Early Complications After Percutaneous Closure of Atrial Septal Defect in Infants with Procedural Weight Less than 15  kg
The Original version of the article has contained error in method part, page 256 it written: (Source: Mammalian Genome)
Source: Mammalian Genome - February 11, 2021 Category: Genetics & Stem Cells Source Type: research

Hemodynamics under General Anesthesia in Glenn/Fontan Circulation?
(Source: Mammalian Genome)
Source: Mammalian Genome - February 7, 2021 Category: Genetics & Stem Cells Source Type: research

A New Year!
(Source: Mammalian Genome)
Source: Mammalian Genome - February 4, 2021 Category: Genetics & Stem Cells Source Type: research

Timing of Transfer and Mortality in Neonates with Hypoplastic Left Heart Syndrome in California
AbstractMaternal race/ethnicity is associated with mortality in neonates with hypoplastic left heart syndrome (HLHS). We investigated whether maternal race/ethnicity and other sociodemographic factors affect timing of transfer after birth and whether timing of transfer impacts mortality in infants with HLHS. We linked two statewide databases, the California Perinatal Quality Care Collaborative and records from the Office of Statewide Health Planning and Development, to identify cases of HLHS born between 1/1/06 and 12/31/11. Cases were divided into three groups: birth at destination hospital, transfer on day of life 0 &nda...
Source: Mammalian Genome - February 3, 2021 Category: Genetics & Stem Cells Source Type: research

Early Evaluation and the Effect of Socioeconomic Factors on Neurodevelopment in Infants with Tetralogy of Fallot
AbstractNeurodevelopmental sequelae are prevalent among patients with congenital heart defects (CHD). In a study of infants and children with repaired tetralogy of Fallot (TOF), we sought to identify those at risk for abnormal neurodevelopment and to test associations between socioeconomic and medical factors with neurodevelopment deficits. Single-center retrospective observational study of patients with repaired TOF that were evaluated at the institution ’s Cardiac Kids Developmental Follow-up Program (CKDP) between 2012 and 2018. Main outcomes included neurodevelopmental test scores from the Bayley Infant Neurodeve...
Source: Mammalian Genome - February 3, 2021 Category: Genetics & Stem Cells Source Type: research

Oxygen Uptake Efficiency Slope is Strongly Correlated to VO 2peak Long-Term After Arterial Switch Operation
AbstractAfter the arterial switch operation (ASO) for transposition of the great arteries (TGA), many patients have an impaired exercise tolerance. Exercise tolerance is determined with cardiopulmonary exercise testing by peak oxygen uptake (VO2peak). Unlike VO2peak, the oxygen uptake efficiency slope (OUES) does not require a maximal effort for interpretation. The value of OUES has not been assessed in a large group of patients after ASO. The purpose of this study was to determine OUES and VO2peak, evaluate its interrelationship and assess whether exercise tolerance is related to ventricular function after ASO. A cardiopu...
Source: Mammalian Genome - February 1, 2021 Category: Genetics & Stem Cells Source Type: research

Children and Adolescents Treated for Valvular Aortic Stenosis Have Different Physical Activity Patterns Compared to Healthy Controls: A Methodological Study in a National Cohort
AbstractPrevious research in children and adolescents with congenital heart defects presents contradictory findings concerning their physical activity (PA) level, due to methodological limitations in the PA assessment. The aim of the present cross-sectional study was to compare PA in children and adolescents treated for valvular aortic stenosis with healthy controls using an improved accelerometer method. Seven-day accelerometer data were collected from the hip in a national Swedish sample of 46 patients 6 –18 years old treated for valvular aortic stenosis and 44 healthy controls matched for age, gender, geograp...
Source: Mammalian Genome - February 1, 2021 Category: Genetics & Stem Cells Source Type: research

High ECG Risk-Scores Predict Late Gadolinium Enhancement on Magnetic Resonance Imaging in HCM in the Young
In conclusions, ECG risk-score >  2 p could be used as a cut-off for screening of myocardial fibrosis. Thus ECG risk-score is an inexpensive complementary tool in risk stratification of HCM in the young. (Source: Mammalian Genome)
Source: Mammalian Genome - January 30, 2021 Category: Genetics & Stem Cells Source Type: research

Modified Single-Patch Technique Versus Two-Patch Technique for the Repair of Complete Atrioventricular Septal Defect: An Updated Meta-Analysis
(Source: Mammalian Genome)
Source: Mammalian Genome - January 30, 2021 Category: Genetics & Stem Cells Source Type: research

Survival Outcomes of Two-Stage Intracardiac Repair in Large Ventricular Septal Defect and Trisomy 18
ConclusionTwo-stage ICR improves the long-term survival of patients with VSDs and T18. This safe surgical strategy can also prevent pulmonary hypertension in such patients. (Source: Mammalian Genome)
Source: Mammalian Genome - January 29, 2021 Category: Genetics & Stem Cells Source Type: research

Association of Fetal Atrial Flutter with Neonatal Atrioventricular Re-entry Tachycardia Involving Accessory Pathway: A Link to be Remembered
This study is a retrospective review of all fetuses that presented with atrial flutter from January 2001 to December 2019 at the University Hospital of Wales, Cardiff, UK. The specific type of arrhythmia, its time of appearance and clinical characteristics, echocardiographic findings, medical management, and postnatal outcomes were evaluated. Sixteen fetuses were diagnosed with atrial flutter (AFL). Thirteen fetuses had persistent AFL and three fetuses had intermittent AFL. Seven patients had hydrops, of which one had Ebstein ’s anomaly and the other six had normal hearts. Three of the fetuses that presented with AFL...
Source: Mammalian Genome - January 29, 2021 Category: Genetics & Stem Cells Source Type: research

Femoral Artery Thrombosis After Pediatric Cardiac Catheterization
AbstractFemoral artery thrombosis (FAT) is an adverse event post-catheterization. We decided to study the incidence and risk factors of FAT before and after initiation of a pulse loss monitoring program. All cardiac catheterization cases performed using femoral arterial vascular access were retrospectively reviewed. The study period was divided into two eras: before (era 1), and after the initiation of the protocol (era 2). The primary outcome was FAT requiring therapy. Univariable and multivariable logistic regression models were used to identify factors associated with FAT. Receiver operating characteristic curve were ge...
Source: Mammalian Genome - January 25, 2021 Category: Genetics & Stem Cells Source Type: research

Effect of Temporal and Spatial Smoothing on Speckle –Tracking-Derived Strain in Neonates
This study examined nine different combinations of spatial and temporal smoothing on peak systolic left ventricular longitudinal strain in 36 healthy neonates. Strain values were acquired from four-chamber echocardiographic images in the software-defined epicardial, midwall, and en docardial layers in the six standard segments and average four-chamber stain. Strain values were compared using repeated measure ANOVAs. Overall, spatial smoothing had a larger impact than temporal smoothing, and segmental strain values were more sensitive to smoothing settings than average four-cha mber strain. Apicoseptal strain decreased by a...
Source: Mammalian Genome - January 25, 2021 Category: Genetics & Stem Cells Source Type: research

Determinants of Physical Fitness in Children with Repaired Congenital Heart Disease
AbstractThe aim of this study was to determine factors associated with physical fitness (PF) in children who underwent surgery for congenital heart disease (CHD). Sixty-six children (7 –14 years) who underwent surgery for ventricular septal defect (n = 19), transposition of great arteries (n = 22), coarctation of aorta (n = 10), and tetralogy of Fallot (n = 15) were included. All children performed PF tests: cardiorespiratory fitness, upper- and lower-limb muscle strength, speed, balance, and flexibility. Cardiac evaluation was done via echocardiography and...
Source: Mammalian Genome - January 23, 2021 Category: Genetics & Stem Cells Source Type: research

Univentricular Pulmonary Artery Banding: How Tight is Tight Enough for Successful Progress?
AbstractWe investigated the effects of intraoperative parameters measured during pulmonary artery banding operations and pre-discharge parameters on the completion of Fontan procedures. Fifty consecutive patients with single-ventricle anomalies and unrestricted pulmonary blood flow who underwent a PAB operation in and were discharged from our hospital were retrospectively analyzed. Patients who underwent a Fontan operation, a Glenn shunt operation, or who were eligible for a Fontan procedure were defined as the “successful group.” Patients who needed rebanding prior to a bidirectional Glenn shunt, patients who ...
Source: Mammalian Genome - January 21, 2021 Category: Genetics & Stem Cells Source Type: research

Upcoming Events in Pediatric Cardiology Pediatric Cardiology 42-1
(Source: Mammalian Genome)
Source: Mammalian Genome - January 20, 2021 Category: Genetics & Stem Cells Source Type: research

Supravalvular and Valvular Pulmonary Stenosis: Predictive Features and Responsiveness to Percutaneous Dilation
AbstractSupravalvular pulmonary stenosis (SVPS) is considered a rare form of pulmonary stenosis (PS) and represents both a diagnostic and therapeutic challenge. There currently exist no reliable echocardiographic criteria to accurately predict the supravalvular form. The aims of the study were to describe the response to treatment of the different PS presentations and to outline the diagnostic capacity of echocardiogram to differentiate the SVPS from valvular PS (VPS). This retrospective study included 106 patients who underwent percutaneous angioplasty between 2006 and 2017. Interventional outcomes of patients with SVPS w...
Source: Mammalian Genome - January 19, 2021 Category: Genetics & Stem Cells Source Type: research

Predictive Parameters of Decreased Left Ventricular Global Longitudinal Strain at 1 Month After Pediatric Heart Transplantation
In this study, we investigate the predictive capacity of preoperative parameters on the LVGLS decline seen at 1 month post transplant. Forty-six transplant subjects with 2D echocardiographic images sufficient for speckle tracking echocardiography were enrolled. We excluded patients dia gnosed with cardiac allograft vasculopathy or with an episode of rejection 1 month before or after their echocardiographic examinations. The mean LVGLS was significantly reduced at 1 month when compared to 1 year following transplant (− 15.5% vs. − 19.4%, respectively,p 
Source: Mammalian Genome - January 19, 2021 Category: Genetics & Stem Cells Source Type: research

Comparison Between Currently Recommended Long-Term Medical Management of Coronary Artery Aneurysms After Kawasaki Disease and Actual Reported Management in the Last Two Decades
AbstractIn the 2017 American Heart Association (AHA) Kawasaki disease (KD) guidelines, risk levels (RLs) for long-term management are defined by both maximal and current coronary artery (CA) dimensions normalized asz-scores. We sought to determine the degree to which current recommended practice differs from past actual practice, highlighting areas for knowledge translation efforts. The International KD Registry (IKDR) included 1651 patients with CA aneurysms (z-score  >  2.5) from 1999 to 2016. Patients were classified by AHA RL using maximum CAz-score (RL 3  = small, RL 4 = me...
Source: Mammalian Genome - January 13, 2021 Category: Genetics & Stem Cells Source Type: research

Systemic Artery Vasoconstrictor Therapy in Fontan Patients with High Cardiac Output-Heart Failure: A Single-Center Experience
AbstractFailed Fontan Patients with high cardiac output (CO) heart failure (HF) might have vasodilatory syndrome and markedly high mortality rates. The aim of this study was to review the clinical effects of vasoconstrictor therapy (VCT) for failed Fontan hemodynamics. We retrospectively reviewed 10 consecutive patients with Fontan failure (median age, 33  years) and high CO–HF who had received VCT. The hemodynamics were characterized by high central venous pressure (CVP: median, 16 mm Hg), low systolic blood pressure (median, 83 mm Hg), low systemic vascular resistance (median, 8.8 U·m2), high ...
Source: Mammalian Genome - January 8, 2021 Category: Genetics & Stem Cells Source Type: research

Evaluation of Ductal Tissue in Coarctation of the Aorta Using X-Ray Phase-Contrast Tomography
AbstractWe assessed the histological accuracy of X-ray phase-contrast tomography (XPCT) and investigated three-dimensional (3D) ductal tissue distribution in coarctation of the aorta (CoA) specimens. We used nine CoA samples, including the aortic isthmus, ductus arteriosus (DA), and their confluences. 3D images were obtained using XPCT. After scanning, the samples were histologically evaluated using elastica van Gieson (EVG) staining and transcription factor AP-2 beta (TFAP2B) immunostaining. XPCT sectional images clearly depicted ductal tissue distribution as low-density areas. In comparison with EVG staining, the mass de...
Source: Mammalian Genome - January 5, 2021 Category: Genetics & Stem Cells Source Type: research

Does Premature Ventricular Contractions Affect Exercise Capacity in Teenagers with Normal Hearts?
AbstractPremature ventricular contractions (PVCs) are common in teenagers even in the absence of structural heart disease or channelopathy. The suppression of PVCs with exercise is a favorable prognostic indicator. There is a paucity of data regarding the relationship between exercise capacity and PVC burden in this population.  Our objective was to evaluate the association between various exercise stress parameters and PVC burden ascertained with a 24 h Holter in children without structural heart disease and/or channelopathy. In this retrospective study, 447 patient’s charts with a diagnosis of PVC were re...
Source: Mammalian Genome - January 4, 2021 Category: Genetics & Stem Cells Source Type: research

Fate of the Left Pulmonary Artery and Thoracic Aorta After Transcatheter Patent Ductus Arteriosus Closure in Low Birth Weight Premature Infants
AbstractTranscatheter patent ductus arteriosus closure (TCPC) is an emerging treatment for low birth weight extremely premature neonates (EPNs). Left pulmonary artery (LPA) and descending aorta (DAO) obstruction are described device-related complications, however, data on mid- and long-term vascular outcomes are lacking. A retrospective analysis of EPNs who underwent successful TCPC at our institution from 03/2013 to 12/2018 was performed. Two-dimensional echocardiography and spectral Doppler velocities from various time points before and after TCPC were used to identify LPA and DAO flow disturbances. A total of 44 EPNs un...
Source: Mammalian Genome - January 4, 2021 Category: Genetics & Stem Cells Source Type: research

Impact of Treatment Strategy on Outcomes in Isolated Pulmonary Artery of Ductal Origin
AbstractIsolated pulmonary artery (PA) of ductal origin (IPADO) is a rare cardiac defect which requires surgical repair, with or without preceding palliation. We sought to determine the impact of treatment strategy on outcomes. Retrospective study of consecutive patients with IPADO that underwent staged or primary repair from 1/05 to 9/16 at 6 Congenital Cardiac Research Collaborative centers. Patients with single ventricle physiology, major aortopulmonary collaterals, or bilateral IPADO were excluded. Primary outcome was isolated PA z-score at late follow-up. Secondary outcomes included PA symmetry index (isolated:conflue...
Source: Mammalian Genome - January 4, 2021 Category: Genetics & Stem Cells Source Type: research

Retraining Convolutional Neural Networks for Specialized Cardiovascular Imaging Tasks: Lessons from Tetralogy of Fallot
AbstractVentricular contouring of cardiac magnetic resonance imaging is the gold standard for volumetric analysis for repaired tetralogy of Fallot (rTOF), but can be time-consuming and subject to variability. A convolutional neural network (CNN) ventricular contouring algorithm was developed to generate contours for mostly structural normal hearts. We aimed to improve this algorithm for use in rTOF and propose a more comprehensive method of evaluating algorithm performance. We evaluated the performance of a ventricular contouring CNN, that was trained on mostly structurally normal hearts, on rTOF patients. We then created ...
Source: Mammalian Genome - January 4, 2021 Category: Genetics & Stem Cells Source Type: research