Myelodysplastic Neoplasms (MDS): The Current and Future Treatment Landscape
Curr Oncol. 2024 Apr 3;31(4):1971-1993. doi: 10.3390/curroncol31040148.ABSTRACTMyelodysplastic neoplasms (MDS) are a heterogenous clonal disorder of hemopoietic stem cells characterized by cytomorphologic dysplasia, ineffective hematopoiesis, peripheral cytopenias and risk of progression to acute myeloid leukemia (AML). Our understanding of this disease has continued to evolve over the last century. More recently, prognostication and treatment have been determined by cytogenetic and molecular data. Specific genetic abnormalities, such as deletion of the long arm of chromosome 5 (del(5q)), TP53 inactivation and SF3B1 mutati...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Daniel Karel Claire Valburg Navitha Woddor Victor E Nava Anita Aggarwal Source Type: research
Effects of Trehalose Preconditioning on H9C2 Cell Viability and Autophagy Activation in a Model of Donation after Circulatory Death for Heart Transplantation
Curr Issues Mol Biol. 2024 Apr 12;46(4):3353-3363. doi: 10.3390/cimb46040210.ABSTRACTDonation after circulatory death (DCD) is a promising strategy for alleviating donor shortage in heart transplantation. Trehalose, an autophagy inducer, has been shown to be cardioprotective in an ischemia-reperfusion (IR) model; however, its role in IR injury in DCD remains unknown. In the present study, we evaluated the effects of trehalose on cardiomyocyte viability and autophagy activation in a DCD model. In the DCD model, cardiomyocytes (H9C2) were exposed to 1 h warm ischemia, 1 h cold ischemia, and 1 h reperfusion. Trehalose was adm...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Jingwen Gao Yasushige Shingu Satoru Wakasa Source Type: research
Susceptibility of solid organ transplant recipients to viral pathogens with zoonotic potential: A mini-review
Braz J Infect Dis. 2024 Apr 23:103742. doi: 10.1016/j.bjid.2024.103742. Online ahead of print.ABSTRACTA substantial number of zoonotic diseases are caused by viral pathogens, representing a significant menace to public health, particularly to susceptible populations, such as pregnant women, the elderly, and immunocompromised individuals. Individuals who have undergone solid organ transplantation frequently experience immunosuppression, to prevent organ rejection and, thus more prone to opportunistic infections. Furthermore, the reactivation of dormant viruses can threaten transplant recipients and organ viability. This min...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Karine C Bezerra Carlos Meton A G Vieira Edmilson F de Oliveira-Filho Christian Robson S Reis Reinaldo B Ori á Source Type: research
Nutritional status and its relationship with COVID-19 prognosis in hemodialysis patients
CONCLUSIONS: higher body mass index and higher body fat content, along with lower baseline levels of triglycerides and ferritin, are significantly associated with higher COVID-19 mortality in patients on chronic hemodialysis. These findings suggest that the initial nutritional status of these patients can significantly influence the prognosis of SARSCoV-2 infection.PMID:38666342 | DOI:10.20960/nh.04850 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Paz Andrea Bersano-Reyes Gema Nieto Alicia Cana-Poyatos Paula Guerrero Sanz Rafa Garc ía-Maset Alicia Garc ía-Testal Source Type: research
Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids
CONCLUSIONS: We demonstrated that direct injection of hiPSC-CSs restores the contractile functions of injured primate hearts with an acceptable risk of posttransplant arrhythmia. Although the mechanism for the functional benefits is not fully elucidated, these findings provide a strong rationale for conducting clinical trials using the equivalent CM products.PMID:38666382 | DOI:10.1161/CIRCULATIONAHA.123.064876 (Source: Circulation)
Source: Circulation - April 26, 2024 Category: Cardiology Authors: Hideki Kobayashi Shugo Tohyama Hajime Ichimura Noburo Ohashi Shuji Chino Yusuke Soma Hidenori Tani Yuki Tanaka Xiao Yang Naoko Shiba Shin Kadota Kotaro Haga Taijun Moriwaki Yuika Morita-Umei Tomohiko C Umei Otoya Sekine Yoshikazu Kishino Hideaki Kanazawa Source Type: research
True Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Considerations-Brief Report
Curr Oncol. 2024 Apr 5;31(4):2067-2075. doi: 10.3390/curroncol31040153.ABSTRACTDonor cell leukemia (DCL) is a rare complication after allogeneic hematopoietic stem cell transplantation (HSCT) accounting for 0.1% of relapses and presenting as secondary leukemia of donor origin. Distinct in phenotype and cytogenetics from the original leukemia, DCL's clinical challenge lies in its late onset. Its origin is affected by donor cell anomalies, transplant environment, and additional mutations. A 43-year-old woman, treated for early stage triple-negative breast cancer, developed mixed-phenotype acute leukemia (MPAL), 12 years late...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Mich èle Hoffmann Yara Banz J örg Halter Jacqueline Schoumans Jo ëlle Tchinda Ulrike Bacher Thomas Pabst Source Type: research
Myelodysplastic Neoplasms (MDS): The Current and Future Treatment Landscape
Curr Oncol. 2024 Apr 3;31(4):1971-1993. doi: 10.3390/curroncol31040148.ABSTRACTMyelodysplastic neoplasms (MDS) are a heterogenous clonal disorder of hemopoietic stem cells characterized by cytomorphologic dysplasia, ineffective hematopoiesis, peripheral cytopenias and risk of progression to acute myeloid leukemia (AML). Our understanding of this disease has continued to evolve over the last century. More recently, prognostication and treatment have been determined by cytogenetic and molecular data. Specific genetic abnormalities, such as deletion of the long arm of chromosome 5 (del(5q)), TP53 inactivation and SF3B1 mutati...
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Daniel Karel Claire Valburg Navitha Woddor Victor E Nava Anita Aggarwal Source Type: research
Effects of Trehalose Preconditioning on H9C2 Cell Viability and Autophagy Activation in a Model of Donation after Circulatory Death for Heart Transplantation
Curr Issues Mol Biol. 2024 Apr 12;46(4):3353-3363. doi: 10.3390/cimb46040210.ABSTRACTDonation after circulatory death (DCD) is a promising strategy for alleviating donor shortage in heart transplantation. Trehalose, an autophagy inducer, has been shown to be cardioprotective in an ischemia-reperfusion (IR) model; however, its role in IR injury in DCD remains unknown. In the present study, we evaluated the effects of trehalose on cardiomyocyte viability and autophagy activation in a DCD model. In the DCD model, cardiomyocytes (H9C2) were exposed to 1 h warm ischemia, 1 h cold ischemia, and 1 h reperfusion. Trehalose was adm...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Jingwen Gao Yasushige Shingu Satoru Wakasa Source Type: research
A preoperative use of manual therapy in a patient with idiopathic pulmonary fibrosis awaiting lung transplant: a case report
DISCUSSION: The utilization of MT appeared to address the patient's impairments, improved quality of life, improved pulmonary function and improved transplant outcomes.PMID:38666526 | DOI:10.1080/09593985.2024.2343046 (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - April 26, 2024 Category: Physiotherapy Authors: Beth Moody Jones Adam Walsh Kathy Lee Bishop Source Type: research
High-dose Alemtuzumab-Cyclosporine vs Tacrolimus-Methotrexate-Sirolimus for Chronic Graft-versus-Host Disease Prevention
Blood Adv. 2024 Apr 26:bloodadvances.2023010973. doi: 10.1182/bloodadvances.2023010973. Online ahead of print.ABSTRACTChronic graft-versus-host disease (cGVHD) remains a significant problem for patients after allogeneic hematopoietic stem cell transplants (allo-HSCT). While in vivo lymphodepletion by antibodies for cGVHD prophylaxis has been explored in the myeloablative setting, its effects after reduced intensity conditioning (RIC) are not well described. Patients (n=83) with hematologic malignancies underwent targeted lymphodepletion chemotherapy followed by a RIC allo-HSCT using peripheral blood stem cells from unrelat...
Source: Adv Data - April 26, 2024 Category: Epidemiology Authors: Noa G Holtzman Lauren M Curtis Rachel B Salit Brian C Shaffer Filip Pirsl Alen Ostojic Seth M Steinberg Eduard Schulz Jennifer S Wilder Thomas E Hughes Jeremy Rose Sarfraz Memon Robert Korngold Juan Gea-Banacloche Daniel H Fowler Frances T Hakim Ronald E Source Type: research
Modified Delphi Panel Consensus Recommendations for Management of Severe Aplastic Anemia
Blood Adv. 2024 Apr 26:bloodadvances.2023011642. doi: 10.1182/bloodadvances.2023011642. Online ahead of print.ABSTRACTSevere aplastic anemia (SAA) is a rare hematologic condition for which there is no clear management algorithm. A panel of 11 adult and pediatric experts on aplastic anemia was assembled and, using the RAND/UCLA modified Delphi panel method, evaluated >600 varying patient care scenarios to develop clinical recommendations for the initial and subsequent management of patients of all ages with SAA. Here we present the panel's recommendations to rule out inherited bone marrow failure (IBMF) syndromes, on sup...
Source: Adv Data - April 26, 2024 Category: Epidemiology Authors: Daria V Babushok Amy E DeZern Carlos de Castro Zora R Rogers David Beenhouwer Michael S Broder Suzanne Fanning Sarah N Gibbs Rabi Hanna Jaroslaw P Maciejewski Bart L Scott Srinivas K Tantravahi Marcin W Wlodarski Irina Yermilov Bhumika J Patel Source Type: research
Adult survivors' perceptions of their childhood and the influences of being treated for acute lymphoblastic leukaemia with allogeneic hematopoietic stem cell transplantation as a child: A phenomenographic study
CONCLUSIONS: The results emphasised that adults who had been treated for childhood ALL with aHSCT were affected both in negative and positive ways during their childhood. This indicates the importance for early psychosocial care interventions directed to children during their treatment, but also the need for person-centred psychological care in long-term outpatient clinics.PMID:38669953 | DOI:10.1016/j.ejon.2024.102592 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - April 26, 2024 Category: Nursing Authors: Susann Arvidsson Elisabeth Brobeck Jens M Nygren Marianne Jarfelt Katarina Aili Maria Olsson Source Type: research
Nutritional status and its relationship with COVID-19 prognosis in hemodialysis patients
CONCLUSIONS: higher body mass index and higher body fat content, along with lower baseline levels of triglycerides and ferritin, are significantly associated with higher COVID-19 mortality in patients on chronic hemodialysis. These findings suggest that the initial nutritional status of these patients can significantly influence the prognosis of SARSCoV-2 infection.PMID:38666342 | DOI:10.20960/nh.04850 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Paz Andrea Bersano-Reyes Gema Nieto Alicia Cana-Poyatos Paula Guerrero Sanz Rafa Garc ía-Maset Alicia Garc ía-Testal Source Type: research
RETRACTION: A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation
Am J Hematol. 2024 Apr 26. doi: 10.1002/ajh.27353. Online ahead of print.ABSTRACTRetraction: Feng, C-J. , Zhao, P. , Fu, H-X. , Yan, C-H. , Wang, C-C. , Zhu, X-L. , He, Y. , Wang, F-R. , Zhang, Y-Y. , Mo, X-D. , Kong, Y. , Han, W. , Wang, J-Z. , Wang, Y. , Chen, H. , Chen, Y-H. , Zhao, X-Y. , Chang, Y-J. , Xu, L-P. , Liu, K-Y. , Huang, X-J. , Zhang, X-H. (2023) A predictive model of herpes zoster after allogeneic hematopoietic stem cell transplantation: VZV reactivation following antiviral prophylaxis discontinuation. American Journal of Hematology. https://doi.org/10.1002/ajh.27090. The above article, published online on ...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Source Type: research
Susceptibility of solid organ transplant recipients to viral pathogens with zoonotic potential: A mini-review
Braz J Infect Dis. 2024 Apr 23:103742. doi: 10.1016/j.bjid.2024.103742. Online ahead of print.ABSTRACTA substantial number of zoonotic diseases are caused by viral pathogens, representing a significant menace to public health, particularly to susceptible populations, such as pregnant women, the elderly, and immunocompromised individuals. Individuals who have undergone solid organ transplantation frequently experience immunosuppression, to prevent organ rejection and, thus more prone to opportunistic infections. Furthermore, the reactivation of dormant viruses can threaten transplant recipients and organ viability. This min...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Karine C Bezerra Carlos Meton A G Vieira Edmilson F de Oliveira-Filho Christian Robson S Reis Reinaldo B Ori á Source Type: research
