Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio
(Source: Gastroenterology)
Source: Gastroenterology - April 26, 2024 Category: Gastroenterology Authors: Nicolas BENECH, Nadim CASSIR, Tatiana GALPERINE, Laurent ALRIC, Julien SCANZI, Harry SOKOL, French Fecal Transplant Group (GFTF) Tags: Correspondence Source Type: research
Results from a first-in-human phase i safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma
ConclusionsThis pilot study suggests that insertion of pedicled autologous TPFF/PCF along a GBM resection cavity is safe and feasible. Based on the encouraging response rate in 6-month PFS and OS, larger phase II studies are warranted to assess and reproduce safety, feasibility, and efficacy.Trial registration number and date of registration for prospectively registered trialsClinicalTrials.gov ID NCT03630289, dated: 08/02/2018. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
My Journey as a Heart Transplantation Patient …and What I Want Providers to Know: Part II
JCF is honored to share this Patient Experience Series over the next 3 weeks. If you have not yet read the first part of this series, you can do so here (https://doi.org/10.1016/j.cardfail.2024.04.005). Part II of the series is below. The full story will be published in the May 2024 issue and online under our Patient and Caregiver Center at www.jcfonline.com. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 26, 2024 Category: Cardiology Authors: Mark Booras Source Type: research
Viruses, Vol. 16, Pages 682: Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV)
unetto
Anna Linda Zignego
Carmine Coppola
Andrea Iannone
Elisa Biliotti
Elena Rosselli Del Turco
Marco Massari
Anna Licata
Francesco Barbaro
Marcello Persico
Filomena Morisco
Maurizio Pompili
Federica Cerini
Massimo Puoti
Teresa Santantonio
Antonio Craxì
Loreta A. Kondili
Liliana Chemello Investigators
on behalf of PITER Collaborating Investigators on behalf of PITER Collaborating Investigators
The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in peop...
Source: Viruses - April 26, 2024 Category: Virology Authors: Maria Giovanna Quaranta Luisa Cavalletto Francesco Paolo Russo Vincenza Calvaruso Luigina Ferrigno Alberto Zanetto Benedetta Mattioli Roberta D ’Ambrosio Valentina Panetta Giuseppina Brancaccio Giovanni Raimondo Maurizia Rossana Brunetto Anna Linda Zign Tags: Article Source Type: research
Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Living Donor Ethics and Uterus Transplantation
This article provides an in-depth ethical analysis of living donor uterus transplantation, incorporating clinical, psychological, and qualitative study data into the discussion. Although the concept of living organ donors as patients in their own right has not always been present in the field of transplantation, this conceptualization informs the framework for living donor ethics that we apply to living uterus donation. This framework takes root in the principles of research ethics, which include respect for persons, beneficence, and justice. It incorporates an analysis based on eight potential vulnerabilities of living do...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Anji E Wall Giuliano Testa Source Type: research
Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Alpha-1 Antitrypsin Augmentation Therapy in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy and Islet Autotransplantation: A Randomized, Controlled Study
Cell Transplant. 2024 Jan-Dec;33:9636897241243014. doi: 10.1177/09636897241243014.ABSTRACTStress-induced islet graft loss during the peri-transplantation period reduces the efficacy of islet transplantation. In this prospective, randomized, double-blind clinical trial, we evaluated the safety and efficacy of 60 mg/kg human alpha-1 antitrypsin (AAT) or placebo infusion weekly for four doses beginning before surgery in chronic pancreatitis (CP) patients undergoing total pancreatectomy and islet autotransplantation (TP-IAT). Subjects were followed for 12 months post-TP-IAT. The dose of AAT was safe, as there was no difference...
Source: Cell Transplantation - April 25, 2024 Category: Cytology Authors: Hongjun Wang Wenyu Gou Paul J Nietert Jason Hirsch Jingjing Wang Ahmed Allawi Abd S Mortadha Kelsey Cook Morgan Overstreet Hua Wei David Adams William P Lancaster Katherine A Morgan Charlie Strange Source Type: research
Living Donor Ethics and Uterus Transplantation
This article provides an in-depth ethical analysis of living donor uterus transplantation, incorporating clinical, psychological, and qualitative study data into the discussion. Although the concept of living organ donors as patients in their own right has not always been present in the field of transplantation, this conceptualization informs the framework for living donor ethics that we apply to living uterus donation. This framework takes root in the principles of research ethics, which include respect for persons, beneficence, and justice. It incorporates an analysis based on eight potential vulnerabilities of living do...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Anji E Wall Giuliano Testa Source Type: research
Glutamine supplementation improves the activity and immunosuppressive action of induced regulatory T cells in vitro and in vivo
CONCLUSION: Glutamine supplementation can improve the activity and immunosuppressive action of iTregs, and the possible mechanisms by which this occurs are related to cell proliferation, apoptosis, and OXPHOS.PMID:38663757 | DOI:10.1016/j.trim.2024.102044 (Source: Transplant Immunology)
Source: Transplant Immunology - April 25, 2024 Category: Transplant Surgery Authors: Li Zhang Zhongya Xu Yuanjiu Li Ke-Jia Wu Chongyuan Yu Wenjie Zhu Dong-Lin Sun Li Zhu Jun Zhou Source Type: research
Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
World J Gastroenterol. 2024 Apr 7;30(13):1791-1800. doi: 10.3748/wjg.v30.i13.1791.ABSTRACTLiver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. However, long-term side-effects of immunosuppressants, like infection, metabolic disorders and malignant tumor are gaining more attention. Immune tolerance is the status in which LT recipients no longer need to take any immunosuppressants, but the liver function and intrahepatic histol...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ai-Wei Zhou Jing Jin Yuan Liu Source Type: research
Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
World J Gastroenterol. 2024 Apr 7;30(13):1791-1800. doi: 10.3748/wjg.v30.i13.1791.ABSTRACTLiver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. However, long-term side-effects of immunosuppressants, like infection, metabolic disorders and malignant tumor are gaining more attention. Immune tolerance is the status in which LT recipients no longer need to take any immunosuppressants, but the liver function and intrahepatic histol...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Ai-Wei Zhou Jing Jin Yuan Liu Source Type: research
Low-risk delisting strategy in highly sensitized patients without donor offers included in exchange donation programs. One single-center experience
Hum Immunol. 2024 Apr 24:110806. doi: 10.1016/j.humimm.2024.110806. Online ahead of print.ABSTRACTDonor exchange programs were designed to allocate organs for highly sensitized (HS) patients. The allocation algorithm differs slightly among countries and includes different strategies to improve access to transplants in HS patients. However, many HS patients with a calculated panel reactive of antibodies (cPRA) of 100 % remain on the waiting list for a long time. Some allocation algorithms assume immunological risk, including Imlifidase treatment, to increase the chance of transplantation in very HS patients. Here, we descri...
Source: Human Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Alejandra Comins-Boo Juan Irure-Ventura Maria O Valentin Lara Belmar-Vega Covadonga L ópez Del Moral Cuesta Rosal ía Valero San Cecilio Emilio Rodrigo Calabia M ónica Renuncio-García Carolina Castro Hern ández Dzmitry Mikhalkovich Nerea Mota P érez Source Type: research
Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia that Underwent Hematopoietic Stem Cell Transplantation
CONCLUSION: HRQoL is generally good in β-TM transplanted patients and may significantly contribute in deciding whether or not to transplant a β-TM patient treated with conventional therapy.PMID:38659631 | PMC:PMC11037551 | DOI:10.2174/17450179-v17-e211208-2021-HT2-1910-4 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Olga Mulas Ilaria Pili Marco Sanna Giorgio La Nasa Source Type: research
Alpha-1 Antitrypsin Augmentation Therapy in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy and Islet Autotransplantation: A Randomized, Controlled Study
Cell Transplant. 2024 Jan-Dec;33:9636897241243014. doi: 10.1177/09636897241243014.ABSTRACTStress-induced islet graft loss during the peri-transplantation period reduces the efficacy of islet transplantation. In this prospective, randomized, double-blind clinical trial, we evaluated the safety and efficacy of 60 mg/kg human alpha-1 antitrypsin (AAT) or placebo infusion weekly for four doses beginning before surgery in chronic pancreatitis (CP) patients undergoing total pancreatectomy and islet autotransplantation (TP-IAT). Subjects were followed for 12 months post-TP-IAT. The dose of AAT was safe, as there was no difference...
Source: Cell Transplantation - April 25, 2024 Category: Cytology Authors: Hongjun Wang Wenyu Gou Paul J Nietert Jason Hirsch Jingjing Wang Ahmed Allawi Abd S Mortadha Kelsey Cook Morgan Overstreet Hua Wei David Adams William P Lancaster Katherine A Morgan Charlie Strange Source Type: research
