Discovering the Limits of the Possible: Two Can Play That Game
The only way to discover the limits of the possible is to go beyond them into the impossible (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Yael Peled, Michelle M. Kittleson Source Type: research
External validation of population pharmacokinetic models of tacrolimus in Thai adult liver transplant recipients
ConclusionBayesian forecasting is more accurate and precise than other testing methods for predicting drug concentrations. However, none of the evaluated models provides satisfactory predictive performance for generalization to Thai liver transplant patients. This underscores the need for future research to develop population PK models tailored to the Thai population. Such efforts should consider the inclusion of nonlinear pharmacokinetics and region-specific factors, including genetic variability, to improve model accuracy and applicability. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - May 2, 2024 Category: Drugs & Pharmacology Source Type: research
Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients
Blood Cancer Journal, Published online: 02 May 2024; doi:10.1038/s41408-024-01060-4Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - May 2, 2024 Category: Hematology Authors: Ann-Kristin Schm älter Maud Ngoya Jacques-Emmanuel Galimard Ali Bazarbachi J ürgen Finke Nicolaus Kr öger Martin Bornh äuser Matthias Stelljes Friedrich St ölzel Johanna Tischer Thomas Schroeder Peter Dreger Igor-Wolfgang Blau Bipin Savani Sebastian Source Type: research
Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model
In this study, we examined whether hypothermic cardioprotection was attenuated in aged donor hearts during transplantation and evaluated potential therapeutic targets. Using a rat heart transplantation model, we found that hypothermic cardioprotection was impaired in aged donor hearts but preserved in young donor hearts. RNA-Seq showed that cold-inducible RNA-binding protein (Cirbp) expression was decreased in aged donor hearts, and these hearts showed severe ferroptosis after transplantation. The young donor hearts from Cirbp-KO rats exhibited attenuated hypothermic cardioprotection, but Cirbp overexpression in aged donor...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Yifan Zhu, Chenyu Jiang, Jian He, Chen He, Xingliang Zhou, Xu Huang, Yi Shen, Liwei Wu, Yongnan Li, Bei Feng, Yi Yan, Jun Li, Hao Zhang, Yiwei Liu Source Type: research
Prospective study of hepatitis B and D epidemiology and risk factors in Romania: A 10-year update
CONCLUSION: This study shows that HDV infection among those with HBV remains endemic in Romania and updates our understanding of HDV epidemiology and associated risk factors. It emphasizes the need for systematic screening for HDV infection and collaborative initiatives for controlling and preventing HBV and HDV infection.PMID:38689751 | PMC:PMC11056896 | DOI:10.4254/wjh.v16.i4.640 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Speranta Iacob Liana Gheorghe Mirela Onica Laura Huiban Corina Silvia Pop Ciprian Brisc Roxana Sirli Carmen Ester Cristina Mihaela Brisc Sorina Diaconu Ion Rogoveanu Larisa Sandulescu Deiana Vuletici Anca Trifan Source Type: research
Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen: Novel viral biomarkers for chronic hepatitis B management
World J Hepatol. 2024 Apr 27;16(4):550-565. doi: 10.4254/wjh.v16.i4.550.ABSTRACTThe management of hepatitis B virus (HBV) infection now involves regular and appropriate monitoring of viral activity, disease progression, and treatment response. Traditional HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic effectiveness. Quantitation of HBV core antibodies (qAnti-HBc) is a novel non-invasive biomarker that may help with a variety of diagnostic issues. It was shown to correlate strongly with infection stages, hepatic inflammation and fibrosis, chronic infection exacerbations, an...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
< em > Klebsiella pneumoniae < /em > infections after liver transplantation: Drug resistance and distribution of pathogens, risk factors, and influence on outcomes
CONCLUSION: KPIs occur frequently and rapidly after LT. Risk factors include female sex, pre-LT diabetes, increased post-LT ALT levels, and urethral catheter duration. CRKP infections, and not KPIs, affect mortality.PMID:38689752 | PMC:PMC11056902 | DOI:10.4254/wjh.v16.i4.612 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Long Guo Peng Peng Wei-Ting Peng Jie Zhao Qi-Quan Wan Source Type: research
Relative carcinogenicity of tacrolimus < em > vs < /em > mycophenolate after solid organ transplantation and its implications for liver transplant care
CONCLUSION: The contrasting carcinogenic risk profiles of tacrolimus and MPA demonstrated in previous experimental studies, and its application in solid organ transplantation, is yet to be confirmed in clinical studies. Thus, the optimal choice of immunosuppression drug to use as maintenance monotherapy in LT recipients is not supported by a strong evidence base and remains unclear.PMID:38689747 | PMC:PMC11056899 | DOI:10.4254/wjh.v16.i4.650 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Dorothy Liu Mark M Youssef Josephine A Grace Marie Sinclair Source Type: research
Evolution of natural killer cell-targeted therapy for acute myeloid leukemia
Int J Hematol. 2024 May 1. doi: 10.1007/s12185-024-03778-0. Online ahead of print.ABSTRACTIn hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to conventional therapies. Despite advances in treatment, including intensive chemotherapy and hematopoietic stem cell transplantation (HSCT), the prognosis for many patients with AML remains poor. Recently, immunotherapy has emerged as a promising approach to improve outcomes by augmenting existing treatments. Natural killer (NK) cells, a subset of innate lymphoid cells, have garnered attention fo...
Source: International Journal of Hematology - May 1, 2024 Category: Hematology Authors: Yuta Kaito Yoichi Imai Source Type: research
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives
World J Gastroenterol. 2024 Apr 28;30(16):2179-2183. doi: 10.3748/wjg.v30.i16.2179.ABSTRACTIn this editorial we comment on the article published in the recent issue of the World journal of Gastroenterology. We focus specifically on the mechanisms un-derlying the effects of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS), the factors which affect the outcomes of FMT in IBS patients, and challenges. FMT has emerged as a efficacious intervention for clostridium difficile infection and holds promise as a therapeutic modality for IBS. The utilization of FMT in the treatment of IBS has undergone scrutin...
Source: World Journal of Gastroenterology : WJG - May 1, 2024 Category: Gastroenterology Authors: Cong Dai Yu-Hong Huang Min Jiang Source Type: research
Fecal microbiota transplantation for irritable bowel syndrome: Current evidence and perspectives
World J Gastroenterol. 2024 Apr 28;30(16):2179-2183. doi: 10.3748/wjg.v30.i16.2179.ABSTRACTIn this editorial we comment on the article published in the recent issue of the World journal of Gastroenterology. We focus specifically on the mechanisms un-derlying the effects of fecal microbiota transplantation (FMT) for irritable bowel syndrome (IBS), the factors which affect the outcomes of FMT in IBS patients, and challenges. FMT has emerged as a efficacious intervention for clostridium difficile infection and holds promise as a therapeutic modality for IBS. The utilization of FMT in the treatment of IBS has undergone scrutin...
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Cong Dai Yu-Hong Huang Min Jiang Source Type: research
High CD34-positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft-versus-host disease or mortality
DISCUSSION: We found no difference in survival, relapse, or GVHD incidence or severity in patients receiving CD34+ doses above prior cutoffs reported in the literature. These data do not support the routine use of graft CD34+ dose reduction.PMID:38693089 | DOI:10.1111/trf.17864 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Zachary M Avigan Ajoy L Dias Laura E Dodge Jon E Arnason Robin M Joyce Jessica Liegel Jacalyn Rosenblatt Matthew J Weinstock David E Avigan Richard L Haspel Source Type: research
Patterns of red blood cell utilization: Harnessing electronic health records data from the Information Standard for Blood and Transplant (ISBT) 128 system within the Biologics Effectiveness and Safety (BEST) initiative
This study shows that the ISBT 128 coding system in an EHR environment provides a feasible source for hemovigilance activities.PMID:38689458 | DOI:10.1111/trf.17852 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Joyce Obidi Gayathri Sridhar Gra ça M Dores Barbee Whitaker Carlos H Villa Emily Storch Kinnera Chada Lisa M Schilling Karthik Natarajan Paul Biondich Andrey Soares Matthew Spotnitz Thomas Falconer Saptarshi Purkayastha Nicole L Draper Hui-Lee Wong Matth Source Type: research
The roles of epigenetic regulation in graft-versus-host disease
Biomed Pharmacother. 2024 Apr 30;175:116652. doi: 10.1016/j.biopha.2024.116652. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (aHSCT) is utilized as a potential curative treatment for various hematologic malignancies. However, graft-versus-host disease (GVHD) post-aHSCT is a severe complication that significantly impacts patients' quality of life and overall survival, becoming a major cause of non-relapse mortality. In recent years, the association between epigenetics and GVHD has garnered increasing attention. Epigenetics focuses on studying mechanisms that affect gene expression without...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Yimin Wang Qi Liu Lei Deng Xiting Ma Yuling Gong Yifei Wang Fang Zhou Source Type: research
Brentuximab Vedotin Plus Ibrutinib in Relapsed and Refractory Hodgkin Lymphoma
DISCUSSION: The combination of BV and ibrutinib was active in r/r HL; however, given significant toxicity, it cannot be recommended for future development.PMID:38693037 | DOI:10.1016/j.clml.2024.03.013 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - May 1, 2024 Category: Cancer & Oncology Authors: Matthew Mei Ni-Chun Tsai Joycelynne Palmer Saro Armenian Robert Chen Steven Rosen Stephen Forman Leslie Popplewell Larry Kwak Peter Martin Kami Maddocks David Bond Alex F Herrera Source Type: research
