Incidental Finding and Treatment of An Anomalous Aortic Origin of the Right Coronary Artery in a Pediatric Donor ’s Heart prior to Implantation
Coronary artery anomalies in donor hearts are an infrequent incidental finding during intraoperative coronary artery inspection. Herein, we report a pediatric case of restrictive cardiomyopathy with secondary pulmonary hypertension, who underwent a heart transplant, and the procured heart was discovered to have a right coronary artery (RCA) anomaly with anomalous origin from the ascending aorta and with an intramural course. This necessitated RCA unroofing during the transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 18, 2024 Category: Transplant Surgery Authors: Fumiya Yoneyama, Iki Adachi, William J Dreyer, Silvana Molossi, Jeffery S. Heinle, Ziyad Binsalamah Tags: Case Anecdotes, Comments and Opinions Source Type: research

Right ventricular pressure-strain relationship-derived myocardial work reflects contractility: validation with invasive pressure-volume analysis
Three-dimensional (3D) echocardiography-derived right ventricular (RV) ejection fraction (EF) and global longitudinal strain (GLS) are valuable RV functional markers; nevertheless, they are substantially load-dependent. Global myocardial work index (GMWI) is a novel parameter calculated by the area of the RV pressure-strain loop. By adjusting myocardial deformation to instantaneous pressure, it may reflect contractility.To test this hypothesis, we enrolled 60 patients who underwent RV pressure-conductance catheterization to determine load-independent markers of RV contractility and ventriculo-arterial coupling. (Source: Th...
Source: The Journal of Heart and Lung Transplantation - March 18, 2024 Category: Transplant Surgery Authors: B álint Károly Lakatos, Zvonimir Rako, Ádám Szijártó, Bruno R. Brito da Rocha, Manuel J. Richter, Alexandra Fábián, Henning Gall, Hossein A. Ghofrani, Nils Kremer, Werner Seeger, Daniel Zedler, Selin Yildiz, Athiththan Yogeswaran, Béla Merkely, K Tags: Brief Communication Source Type: research

Impact of Controlled Hypothermic Preservation on Outcomes Following Heart Transplantation
Severe primary graft dysfunction (PGD) is a major cause of early mortality after heart transplant. but the impact of donor organ preservation conditions on severity of PGD and survival have not been well characterized. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 17, 2024 Category: Transplant Surgery Authors: David D ’Alessandro, Jacob Schroder, Dan M. Meyer, Andrija Vidic, Yasuhiro Shudo, Scott Silvestry, Marzia Leacche, Christopher M. Sciortino, Maria Rodrigo, Si M. Pham, Hannah Copeland, Jeffrey P. Jacobs, Masashi Kawabori, Koji Takeda, Andreas Zuckermann Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 15, 2024 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 15, 2024 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 15, 2024 Category: Transplant Surgery Source Type: research

Alveolar Macrophage –CD8 T Cell Interactions after Acute Lung Allograft Dysfunction: Insights from Single-Cell RNA Sequencing
Editorial: (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 12, 2024 Category: Transplant Surgery Authors: Peter T. Bell, Andrew E. Gelman Tags: Editorial Source Type: research

Sex-Specific Patterns of Donor-Derived Cell-Free DNA in Heart Transplant Rejection: An Analysis from the Genomic Research Alliance for Transplantation (GRAfT)
Non-invasive methods for surveillance of acute rejection are increasingly used in heart transplantation (HT), including donor-derived cell-free DNA (dd-cfDNA). As other cardiac biomarkers differ by sex, we hypothesized that there may be sex-specific differences in performance of dd-cfDNA for detection of acute rejection. The purpose of the current study was to examine patterns of dd-cfDNA seen in quiescence and acute rejection in males and female transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 7, 2024 Category: Transplant Surgery Authors: Ersilia M. DeFilippis, Benjamin Sweigart, Kiran K. Khush, Palak Shah, Sean Agbor-Enoh, Hannah A. Valantine, Amanda R. Vest Source Type: research

Impact of Prolonged Ischemic Time on Pediatric Heart Transplantation Outcomes: Improved Outcomes in the Most Recent Era
Impacts of ischemic time (IT) on pediatric heart transplant outcomes are multifactorial. We aimed to analyze the effect of prolonged IT on graft loss after pediatric heart transplantation. We hypothesized that graft survival with prolonged IT has improved across eras. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 7, 2024 Category: Transplant Surgery Authors: Scott R. Auerbach, Adam Arshad, Estela Azeka, Ryan S. Cantor, James K. Kirklin, Devin Koehl, JonDavid Menteer, David M. Peng, William Ravekes, Fawwaz R. Shaw, Renata Shih, Jacob Simmonds, Jean Ballweg Source Type: research

IL-33: Friend or Foe in Transplantation?
Several reports have highlighted the dichotomous nature of the IL-33 system in cardiac and lung disease, where this cytokine can exert both protective effects and drive pro-inflammatory responses in a context-specific manner. This State-of-the-Art review focuses on preclinical mechanistic studies of the IL-33 system in development of allograft rejection in heart and lung transplantation. We address the scope of potential cellular sources of IL-33 and pathways for cellular release that may impact the study of this cytokine system in transplant models. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 5, 2024 Category: Transplant Surgery Authors: Ghandi F. Hassan, Lucy S. Cohen, Jen Alexander-Brett Tags: State of the art Source Type: research

Oversizing lung allografts deteriorates outcomes in patients with pulmonary fibrosis
Lung transplantation is the only curative treatment for patients with end-stage pulmonary fibrosis. Due to the shortage of donor organs most lung allografts are either oversized or undersized. It is still under debate whether over- or undersizing is preferably performed regarding the postoperative outcome. We therefore analysed our data using predicted total lung capacity to compare size-mismatches. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 2, 2024 Category: Transplant Surgery Authors: Maximilian Franz, Saleh Tavil, Nunzio Davide de Manna, Khalil Aburahma, Dietmar Boethig, Dmitry Bobylev, Tobias Welte, Mark Greer, Nicolaus Schwerk, Arjang Ruhparwar, Christian Kuehn, Jawad Salman, Fabio Ius Tags: Original Clinical Science Source Type: research

Knowledge Gaps in Heart and Lung Donation after the Circulatory Determination of Death: Report of a Workshop of the National Heart, Lung, and Blood Institute
In a workshop sponsored by the U.S. National Heart, Lung, and Blood Institute, experts identified current knowledge gaps and research opportunities in the scientific, conceptual, and ethical understanding of organ donation after the circulatory determination of death and its technologies. To minimize organ injury from warm ischemia and produce better recipient outcomes, innovative techniques to perfuse and oxygenate organs postmortem in situ, such as thoracoabdominal normothermic regional perfusion, are being implemented in several medical centers in the US and elsewhere. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 1, 2024 Category: Transplant Surgery Authors: James L. Bernat, Kiran K. Khush, Sam D. Shemie, Matthew G. Hartwig, Peter P. Reese, Anne Dalle Ave, JD Brendan Parent, Alexandra K. Glazier, Alexander M. Capron, Matt Craig, Teneille Gofton, Elisa J. Gordon, Andrew Healey, Mary E. Homan, Keren Ladin, Simo Source Type: research

Anticoagulation in LVAD recipients and thrombembolic complications: Where do we stand? Where are we going to?
Editorial: (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 28, 2024 Category: Transplant Surgery Authors: Alexander M. Bernhardt, Hermann Reichenspurner Tags: Editorial Source Type: research

Vasoplegic Syndrome during Heart Transplantation: A Systematic Review and Meta-analysis
Vasoplegic syndrome (VS) is a common occurrence during heart transplantation (HT). It currently lacks a uniform definition between transplant centers, and its pathophysiology and treatment remain enigmatic. This systematic review summarizes the available published clinical data regarding VS during HT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Nicolas Kumar, Michael G. Fitzsimons, Manoj H. Iyer, Michael Essandoh, Julia E. Kumar, Adam A. Dalia, Asishana Osho, Tamara R. Sawyer, Amit Bardia Tags: Original Clinical Science Source Type: research

Randomized Trial Of Routine Versus On-demand Intraoperative Extracorporeal Membrane Oxygenation In Lung Transplantation: A Feasibility Study
In most centers, extracorporeal membrane oxygenation (ECMO) is the preferred means to provide cardiopulmonary support during lung transplantation. However, there is controversy about whether intraoperative venoarterial (VA) ECMO should be used routinely or selectively. A randomized controlled trial is the best way to address this controversy. In this publication, we describe a feasibility study to assess the practicality of a protocol comparing routine versus selective VA ECMO during lung transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 27, 2024 Category: Transplant Surgery Authors: Basil Nasir, Jason Weatherald, Tim Ramsay, Marcelo Cypel, Laura Donahoe, Chris Durkin, Travis Schisler, Jayan Nagendran, Moishe Liberman, Caroline Landry, Charles Overbeek, Alex Moore, Pasquale Ferraro Source Type: research