Study Results Suggest Less Invasive HeartMate 3 Implantation is a Safe and Effective Approach for Obese Patients
Historically, obesity was considered a relative contraindication to LVAD implantation with less invasive surgery (LIS). The present study aimed to compare the outcomes of obese patients who underwent LVAD implantation through LIS with those who received full sternotomy (FS) implantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - June 11, 2021 Category: Transplant Surgery Authors: Milica Bjelic, Brian Ayers, Frane Paic, Wendy Bernstein, Bryan Barrus, Karin Chase, Yang Gu, Jeffrey D. Alexis, Himabindu Vidula, Christina Cheyne, Sunil Prasad, Igor Gosev Source Type: research

Impact of Thoracotomy Approach on Right Ventricular Failure and Length of Stay in Left Ventricular Assist Device Implants: An Intermacs Registry Analysis
Traditionally, implantation of Left Ventricular Assist Devices (LVADs) is performed via median sternotomy. Recently, less invasive thoracotomy approaches are growing in popularity as they involve less surgical trauma, potentially less bleeding, and may preserve right ventricular function. We hypothesized implantation of LVADs via thoracotomy has less perioperative right ventricular failure (RVF) and shorter postoperative length of stay (LOS). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - June 11, 2021 Category: Transplant Surgery Authors: Brent C Lampert, Jeffrey J Teuteberg, Jennifer Cowger, Nahush A Mokadam, Ryan S. Cantor, Raymond L Benza, Asvin M Ganapathi, Susan L Myers, William Hiesinger, Joseph Woo J, Francis Pagani, James K Kirklin, Bryan A Whitson Tags: Original Clinical Science Source Type: research

The Influence of Mechanical Circulatory Support on Post-Transplant Outcomes in Pediatric Patients: A Multicenter Study from the International Society for Heart and Lung Transplantation (ISHLT) Registry
Mechanical circulatory support (MCS) is increasingly being used as a bridge to transplant in pediatric patients. We compare outcomes in pediatric patients bridged to transplant with MCS from an international cohort. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - June 11, 2021 Category: Transplant Surgery Authors: J.B. Edelson, Y. Huang, H. Griffis, J. Huang, C.E. Mascio, J.M. Chen, K. Maeda, D.S. Burstein, C. Wittlieb-Weber, K.Y. Lin, M.J. O'Connor, J.W. Rossano Tags: Original Clinical Science Source Type: research

Coagulation and wound repair during COVID-19
While COVID-19 is best known as a respiratory infection, SARS-CoV-2 causes systemic disease manifestations including coagulopathies. Both dysregulated extracellular matrix remodeling pathways and circulating coagulation proteins are hallmarks of severe COVID-19 and often continue after the resolution of acute infection. Coagulation proteins have proven effective as biomarkers for severe disease and anti-coagulants are a mainstay of COVID-19 therapeutics in hospitalized patients. While much knowledge has been gained about the role of clotting pathway activation in COVID-19, much remains to be elucidated in this complex netw...
Source: The Journal of Heart and Lung Transplantation - June 11, 2021 Category: Transplant Surgery Authors: Vineet D. Menachery, Lisa E. Gralinski Source Type: research

Recipient and Surgical Factors Trigger Severe Primary Graft Dysfunction After Heart Transplant
: Primary graft dysfunction (PGD) is a major cause of early mortality following heart transplant (HT). The International Society for Heart and Lung Transplantation (ISHLT) subdivides PGD into three grades of increasing severity. Most studies have assessed risk factors for PGD without distinguishing between PGD severity grade. We sought to identify recipient, donor and surgical risk factors specifically associated with mild/moderate or severe PGD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - June 9, 2021 Category: Transplant Surgery Authors: Lillian Benck, Evan P. Kransdorf, Dominic A. Emerson, Joshua Rushakoff, Michelle M. Kittleson, Ellen B. Klapper, Dominick J. Megna, Fardad Esmailian, Chelsea Halprin, Alfredo Trento, Danny Ramzy, Lawrence S.C. Czer, David H. Chang, Joseph E. Ebinger, Jon Source Type: research

Covid-19 in Recipients of Heart and Lung Transplantation: Learning from Experience
As of May 2021, SARS-CoV-2 is estimated to have infected 161 million people worldwide and been responsible for over 3 million deaths.1 Early in the pandemic, the impact of COVID-19 on solid organ transplant recipients was not well established, and initial experience suggested the presentation of COVID-19 in solid organ transplant recipients was similar to that of non-transplant patients.2,3 However, in subsequent reports, heart and lung transplant recipients fared worse than non-transplant patients, with an observed mortality of 20-30%. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - June 9, 2021 Category: Transplant Surgery Authors: Michelle M. Kittleson, Daniel C. Chambers, Marcelo Cypel, Luciano Potena Source Type: research

Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation
Lung transplantation (LTx) is associated with sterile inflammation, possibly related to the release of damage associated molecular patterns (DAMPs) by injured allograft cells. We have measured cellular damage and the release of DAMPs and cytokines in an experimental model of LTx after cold or warm ischemia and examined the effect of pretreatment with ex-vivo lung perfusion (EVLP). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - June 1, 2021 Category: Transplant Surgery Authors: Arpad Hasenauer, Beno ît Bédat, Roumen Parapanov, Jérôme Lugrin, Anne Debonneville, Etienne Abdelnour-Berchtold, Michel Gonzalez, Jean Y. Perentes, Lise Piquilloud, Csaba Szabo, Thorsten Krueger, Lucas Liaudet Source Type: research

Association between chronic lung allograft dysfunction and human Cytomegalovirus UL40 peptide variants in lung-transplant recipients
Natural-Killer (NK-) cells play an important role in the pathogenesis of chronic lung allograft dysfunction (CLAD) in lung-transplant recipients (LTRs). Activating NKG2C+ and inhibitory NKG2A+ NK cells proliferate in response to human Cytomegalovirus (HCMV) infection via the presentation of virally encoded UL40 peptides on HLA-E molecules. We aimed to clarify whether infection with HCMV strains carrying different UL40 peptide variants is associated with the development of CLAD. We included 82 LTRs, 18 patients developing CLAD and 64 matched control patients without CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 31, 2021 Category: Transplant Surgery Authors: Hannes Vietzen, Svenja Hartenberger, Peter Jaksch, Elisabeth Puchhammer-St öckl Source Type: research

Outcomes of pre- heart transplantation desensitization in a series of highly sensitized patients bridged with left ventricular assist devices
Desensitization therapy for heart transplantation (HT) candidates can shorten transplant wait times and broaden the donor pool. Specific evidence-based recommendations on both protocols and indications are lacking. We retrospectively assessed left ventricular assist devices-bridged candidates who received pre-HT desensitization therapy. The therapeutic protocol consisted of intravenous immunoglobulin and rituximab followed by bortezomib and plasmapheresis if an insufficient response was achieved. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 31, 2021 Category: Transplant Surgery Authors: Tareq Al Saadi, Tatyana Lawrecki, Nikhil Narang, Anjali Joshi, Christopher Sciamanna, Sunil Pauwaa, Gregory Macaluso, Antone Tatooles, Patroklos Pappas, William Cotts, Ambar Andrade Source Type: research

Failing Fontan – heart or heart-liver transplant: the jury is (still) out?
This study is seeking to answer a very clinically relevant question for which the authors are to be congratulated, but unfortunately given the limitations in sample size, it is hard to make changes to clinical practice. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 30, 2021 Category: Transplant Surgery Authors: Shahnawaz Amdani Source Type: research

Donor Derived Cell Free DNA% is elevated with pathogens that are risk factors for Acute and Chronic Lung Allograft Injury.
We examined the %ddcfDNA values at times of microbial isolation from bronchoalveolar lavage (BAL).Methods Two hundred and six BAL samples from 51 Lung Transplant Recipients (LTRs) with concurrently available plasma %ddcfDNA were analyzed along with microbiology and histopathology. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 30, 2021 Category: Transplant Surgery Authors: Katrina Bazemore, Michael Rohly, Nitipong Permpalung, Kai Yu, Irina Timofte, A. Whitney Brown, Jonathan Orens, Aldo Iacono, Steven D. Nathan, Robin K Avery, Hannah Valantine, Sean Agbor-Enoh, Pali D Shah Source Type: research

Inferior outcomes in lung transplant recipients with serum Pseudomonas aeruginosa specific cloaking antibodies
Chronic Lung Allograft Dysfunction (CLAD) limits long-term survival following lung transplantation. Colonization of the allograft by Pseudomonas aeruginosa is associated with an increased risk of CLAD and inferior overall survival. Recent experimental data suggests that ‘cloaking’ antibodies targeting the O-antigen of the P. aeruginosa lipopolysaccharide cell wall (cAbs) attenuate complement-mediated bacteriolysis in suppurative lung disease. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 30, 2021 Category: Transplant Surgery Authors: Chandima Divithotawela, Amy Pham, Peter T. Bell, Emma L. Ledger, Maxine Tan, Stephanie Yerkovich, Michelle Grant, Peter M. Hopkins, Timothy J. Wells, Daniel C. Chambers Tags: Original Clinical Science Source Type: research

Intraoperative anti-A/B immunoadsorption is associated with significantly reduced blood product utilisation with similar outcomes in paediatric ABO-incompatible heart transplantation
: Intraoperative anti-A/B immunoadsorption (ABO-IA) was recently introduced for ABO-incompatible heart transplantation. Here we report the first case series of patients transplanted with ABO-IA, and compare outcomes with those undergoing plasma exchange facilitated ABO-incompatible heart transplantation (ABO-PE). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 29, 2021 Category: Transplant Surgery Authors: Richard Issitt, John Booth, Richard Crook, Alex Robertson, Victoria Molyneux, Rebecca Richardson, Nigel Cross, Michael Shaw, Victor Tsang, Vivek Muthurangu, Neil J Sebire, Michael Burch, Matthew Fenton Source Type: research

Increasing Multiorgan Heart Transplantation With Hepatitis C Virus Donors In The Current-era
The trends and outcomes of multiorgan heart-transplantation(HT) using hepatitis C virus(HCV) donors in the contemporary era are sparsely known. Using UNOS registry, 1322 adult multiorgan-HTs(n=986 heart-kidney, n=155 heart-lung, n=181 heart-liver) between August-2015 and August-2020 were identified, of which 109 were performed using HCV-donors[n=77 HCV nucleic-acid-amplification testing(NAT) positive irrespective of antibody(Ab) status(HCV-viremic); and n=32 HCV Ab+/NAT-(HCV Ab+ nonviremic)]. The percentage of HCV-donors used for multiorgan-HT increased from 0% in 2015 to 14% in 2020(p (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 29, 2021 Category: Transplant Surgery Authors: Shivank Madan, Snehal R. Patel, Peter Vlismas, Vagish Hemmige, Omar Saeed, Daniel J. Goldstein, Ulrich P. Jorde Tags: Brief Communication Source Type: research

Implantable Cardioverter Defibrillators in Left Ventricular Assist Device Patients: Α Systematic Review and Meta-analysis
Implantable cardioverter-defibrillators (ICDs) remain the standard of care in advanced heart failure with reduced ejection fraction patients for the prevention of sudden cardiac death. However, current guidelines remain conflicting with respect to the use of ICDs in patients supported with a continuous flow left ventricular assist device (CF-LVAD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 29, 2021 Category: Transplant Surgery Authors: Filippos-Paschalis Rorris, Constantine N. Antonopoulos, Christos P. Kyriakopoulos, Stavros G. Drakos, Christos Charitos Source Type: research

Bronchoalveolar Lavage Cytokine-Based Risk Stratification of Minimal Acute Rejection in Clinically Stable Lung Transplant Recipients
Acute cellular rejection (ACR) remains the most significant risk factor for chronic lung allograft dysfunction (CLAD). While clinically significant or higher-grade ( ≥A2) ACR is generally treated with augmented immunosuppression (IS), the management of clinically stable grade A1 ACR remains controversial. At our center, patients with clinically stable grade A1 ACR are routinely not treated with augmented IS. While the overall outcomes in this group of patients at our center are equivalent to patients with stable A0 pathology, CLAD and death rates remain overall high. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 29, 2021 Category: Transplant Surgery Authors: Liran Levy, Ella Huszti, Musawir Ahmed, Rasheed Ghany, Sarah Hunter, Sajad Moshkelgosha, Chen Yang Kevin Zhang, Kristen Boonstra, William Klement, Jussi Tikkanen, Lianne G Singer, Shaf Keshavjee, Stephen Juvet, Tereza Martinu Tags: Original Clinical Science Source Type: research

Can we decloak how infections drive complications after lung transplantation?
Infections are a major risk factor for chronic lung allograft dysfunction (CLAD), which is the main attributable long-term cause of mortality in lung transplant (LTx) recipients.1 –3 Gram-negative organisms such as Pseudomonas aeruginosa are particularly notorious. In experimental models of lung transplantation, Pseudomonas was shown to facilitate a G-CSF-mediated neutrophilia, followed by effector T cell responses, thus contributing to acute rejection.4 Additionally, Pseud omonas also contributes to humoral alloimmunity, which is a known risk factor for CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 28, 2021 Category: Transplant Surgery Authors: Hrishikesh S. Kulkarni, Erika D. Lease Tags: Editorial Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 27, 2021 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 27, 2021 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 27, 2021 Category: Transplant Surgery Source Type: research

Aspiration of Conjugated Bile Acids Predicts Adverse Lung Transplant Outcomes and Correlates with Airway Lipid and Cytokine Dysregulation
: Duodeno-gastroesophageal reflux aspiration is associated with chronic lung allograft dysfunction (CLAD). Reflux aspirate can contain bile acids (BA), functional molecules in the gastro-intestinal tract with emulsifying properties. We sought to determine and quantify the various BA species in airways of the lung transplant recipients to better understand the various effects of aspirated BA that contribute to post-transplantation outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 27, 2021 Category: Transplant Surgery Authors: Andreacarola Urso, Miguel M Leiva-Ju árez, Domenica F. Briganti, Beatrice Aramini, Luke Benvenuto, Joseph Costa, Renu Nandakumar, Estela Area Gomez, Hilary Y Robbins, Lori Shah, Aversa Meghan, Joshua R Sonnet, Selim Arcasoy, Serge Cremers, Frank D'Ovidio Source Type: research

Cerebral Vasoreactivity in HeartMate 3 Patients
While rates of stroke have declined with the HeartMate3 (HM3) continuous flow (CF) left ventricular assist device (LVAD), the impact of non-pulsatile flow and artificial pulse physiology on cerebrovascular function is not known. We hypothesized that improved hemodynamics and artificial pulse physiology of HM3 patients would augment cerebrovascular metabolic reactivity (CVR) compared with HeartMate II (HMII) CF-LVAD and heart failure (HF) patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 21, 2021 Category: Transplant Surgery Authors: Eric J. St öhr, Ruiping Ji, Koichi Akiyama, Giulio Mondellini, Lorenzo Braghieri, Alberto Pinsino, John R. Cockcroft, Melana Yuzefpolskaya, Amrin Amlani, Veli K. Topkara, Hiroo Takayama, Yoshifumi Naka, Nir Uriel, Koji Takeda, Paolo C. Colombo, Barry J. Tags: Original Research Article Source Type: research

Immunogenicity of BNT162b2 mRNA COVID-19 Vaccine and SARS-CoV-2 Infection in Lung Transplant Recipients
The immunogenicity of the novel mRNA COVID-19 vaccine in immunocompromised lung transplant recipients is still unknown. We compared the antibody response after the first and second doses of the BNT162b2 mRNA COVID-19 vaccine (Pfizer/BioNTech) with the response after natural SARS-CoV-2 infection in lung transplant recipients. None of the vaccinees tested after two doses of the mRNA BNT162b2 vaccine developed anti-SARS-CoV-2 IgG, while 85% patients presented an antibody response after SARS-CoV-2 infection. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 20, 2021 Category: Transplant Surgery Authors: Jan Havlin, Monika Svorcova, Dr Eliska Dvorackova, Dr Jan Lastovicka, Robert Lischke, Associate Professor Tomas Kalina, Petr Hubacek Tags: Brief Communication Source Type: research

Selection and Management of Pediatric and Congenital Heart Disease Patients on Ventricular Assist Devices
adult congenital heart disease (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 19, 2021 Category: Transplant Surgery Authors: Angela Lorts, Jennifer Conway, Martin Schweiger, Authors Alphabetically: Iki Adachi, Shahnawaz Amdani, Scott R. Auerbach, Charlotte Barr, Mark S. Bleiweis, Elizabeth D. Blume, Danielle S. Burstein, Ari Cedars, Sharon Chen, Melissa K. Cousino-Hood, Kevin P Tags: CONSENSUS STATEMENT PAPER Source Type: research

Long-term survival in patients with post-LVAD right ventricular failure: multi-state modelling with competing outcomes of heart transplant.
Multicenter data on long term survival following LVAD implantation that make use of contemporary definitions of RV failure are limited. Furthermore, traditional survival analyses censor patients who receive a bridge to heart transplant. Here we compare the outcomes of LVAD patients who develop post-operative RV failure accounting for the transitional probability of receiving an interim heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 18, 2021 Category: Transplant Surgery Authors: Rohan Shad, Robyn Fong, Nicolas Quach, Cayley Bowles, Patpilai Kasinpila, Michelle Li, Kate Callon, Miguel Castro, Ashrith Guha, Erik. E. Suarez, Sangjin Lee, Stefan Jovinge, Theodore Boeve, Yasuhiro Shudo, Curtis P. Langlotz, Jeffrey Teuteberg, William H Source Type: research

Coronavirus Disease 2019 in Heart Transplant Recipients: Risk Factors, Immunosuppression, and Outcomes
COVID-19 continues to inflict significant morbidity and mortality, particularly on patients with preexisting health conditions. The clinical course, outcomes, and significance of immunosuppression regimen in heart transplant recipients with COVID-19 remains unclear. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 18, 2021 Category: Transplant Surgery Authors: Michael V. Genuardi MD, Noah Moss, Samer S. Najjar, Brian A. Houston, Supriya Shore, Esther Vorovich, Pavan Atluri, Maria Molina, Susan Chambers, Tiffany Sharkoski, Eileen Hsich, Jerry D. Estep, Anjali T. Owens, Kevin M. Alexander, Sunit-Preet Chaudhry, R Tags: Original Clinical Science Source Type: research

Clinical characteristics, management practices, and outcomes among lung transplant patients with COVID-19
There are limited data on management strategies and outcomes among lung transplant (LT) patients with Coronavirus disease 2019 (COVID-19). We implemented management protocols based on the best available evidence and consensus among multidisciplinary teams. The current study reports our experience and outcomes using this protocol-based management strategy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 18, 2021 Category: Transplant Surgery Authors: Manish R. Mohanka, Luke D. Mahan, John Joerns, Adrian Lawrence, Srinivas Bollineni, Vaidehi Kaza, Ricardo M. La Hoz, Corey Kershaw, Lance S. Terada, Fernando Torres, Amit Banga Tags: Original Clinical Science Source Type: research

HLA-DRB1 mismatch-based identification of donor-derived cell free DNA (dd-cfDNA) as a marker of rejection in heart transplant recipients: a single-Institution pilot study
Donor-derived cell-free DNA (dd-cfDNA) is considered a reliable marker of organ damage with potential applications in the follow-up of transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 14, 2021 Category: Transplant Surgery Authors: Monica Sorbini, Gabriele Togliatto, Erika Simonato, Massimo Boffini, Margherita Cappuccio, Alessandro Gambella, Francesca Arruga, Nicola Mora, Matteo Marro, Cristiana Caorsi, Morteza Mansouri, Paola Magistroni, Luisa Delsedime, Mauro Giulio Papotti, Anton Tags: Original Clinical Science Source Type: research

COVID-19 Vaccination Immune Paresis in Heart and Lung Transplantation
Vaccines against symptomatic coronavirus disease-19 (COVID-19) demonstrate marked efficacy within clinical trials of immunocompetent persons with significant reduction in severe COVID-19 disease, hospitalization and death.(1-3) These vaccines utilize mRNA, replication-deficient adenovirus vectors, inactivated SARS-CoV-2 virus, or protein subunits of SARS-CoV-2.(4) Most vaccines target the viral spike protein and the receptor-binding domain (RBD) which facilitates viral entry, and are designed to stimulate both cellular (T-regulatory and T-helper cells) and humoral (IgG anti spike and/or anti-RBD antibody titers) immune res...
Source: The Journal of Heart and Lung Transplantation - May 12, 2021 Category: Transplant Surgery Authors: Saima Aslam, Lara Danziger-Isakov, Mandeep R Mehra Tags: Editorial Source Type: research

Assessing Predicted Heart Mass Size Matching in Obese Heart Transplant Recipients
We examined the use of PHM undersized hearts in obese recipients and assessed its impact on survival. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 11, 2021 Category: Transplant Surgery Authors: Samuel T. Kim, Mark R. Helmers, Amit Iyengar, Benjamin Smood, D. Alan Herbst, William L. Patrick, Jason J. Han, Peter Altshuler, Pavan Atluri Source Type: research

Immune response to COVID-19 in older adults
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV-2 spread from Wuhan, China, across the globe, causing an unprecedented public healthcare crisis. The virus showed remarkable age dependent pathology, with symptoms resembling common cold in most adults and children while causing more severe respiratory distress and significant mortality in older and frail humans. Even before the SARS-CoV-2 outbreak infectious diseases represented one of the major causes of death of older adults. (Source: The Journal of H...
Source: The Journal of Heart and Lung Transplantation - May 11, 2021 Category: Transplant Surgery Authors: Mladen Jergovic, Christopher P. Coplen, Jennifer L. Uhrlaub, Janko Nikolich-Zugich Tags: Invited Review Source Type: research

Severe pulmonary hypertension associated with chronic obstructive pulmonary disease A prospective French multicenter cohort
: A small proportion of patients with chronic obstructive pulmonary disease (COPD) patients present severe pulmonary hypertension (PH), defined by mean pulmonary artery pressure (mPAP) ≥ 35 mm Hg measured by right heart catheterization. Little is known about the characteristics of severe PH-COPD. The aim of the study based on a national registry was to describe this phenotype. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 11, 2021 Category: Transplant Surgery Authors: Ga ëlle Dauriat, Martine Reynaud-Gaubert, Vincent Cottin, Bouchra Lamia, David Montani, Mathieu Canuet, Clement Boissin, Cecile Tromeur, Ari Chaouat, Bruno Degano, Emmanuel Bergot, Olivier Sanchez, Gregoire Prevot, Olivier Sitbon, Gabriel Thabut, Drifa B Tags: Original Clinical Science Source Type: research

Continuing progress toward improved lung assessment
Lung transplantation is an effective therapy for end-stage lung disease (1). As in other types of solid organ transplants, there are limitations to the number of organs available for transplantation. Therefore, efforts to expand the donor pool through use of extended criteria and circulatory death donors are needed (2-8). More recently, use of ex vivo lung perfusion (EVLP) has further expanded the potential donor pool; (9) however, challenges facing all donor expansion strategies are fundamentally the same. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 10, 2021 Category: Transplant Surgery Authors: Edward Cantu Tags: Editorial Source Type: research

Therapeutic Efficacy of Large Aligned Cardiac Tissue Derived from Induced Pluripotent Stem Cell in a Porcine Ischemic Cardiomyopathy Model
Although induced pluripotent stem (iPS) cell-derived cardiac constructs may have a potential in cardiomyogenesis of a distressed myocardium, obtaining polarity in cardiac constructs, such as via myocyte alignment, may be crucial to achieve a maximum contractile force for better clinical outcomes. We herein hypothesized that transplantation of an aligned cardiac tissue derived from iPS cells has therapeutic effects in a porcine ischemic cardiomyopathy model as a preclinical trial. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 7, 2021 Category: Transplant Surgery Authors: Kota Suzuki, Shigeru Miyagawa, Li Liu, Takuji Kawamura, Junjun Li, Xiang Qu, Akima Harada, Koichi Toda, Daisuke Yoshioka, Satoshi Kainuma, Ai Kawamura, Yoshiki Sawa Tags: Original Pre-Clinical Science Source Type: research

The Lung Microbiome in Lung Transplantation
Culture-independent study of the lower respiratory tract after lung transplantation has enabled an understanding of the microbiome – that is, the collection of bacteria, fungi, and viruses, and their respective gene complement – in this niche. The lung has unique features as a microbial environment, with balanced entry from the upper respiratory tract, clearance, and local replication. There are many pressures impacting the microbiome after transplantation, including donor allograft factors, recipient host factors such as underlying disease and ongoing exposure to the microbe-rich upper respiratory tract, and t...
Source: The Journal of Heart and Lung Transplantation - May 6, 2021 Category: Transplant Surgery Authors: John E. McGinniss, Samantha A. Whiteside, Aurea Simon-Soro, Joshua M. Diamond, Jason D. Christie, Fredrick D. Bushman, Ronald G. Collman Tags: Invited Review Source Type: research

The impact of donor sex on heart transplantation outcomes —a study of over 60,000 patients in the United States
The objective of this study was to evaluate the impact of donor sex on heart transplantation outcomes in the United States. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 1, 2021 Category: Transplant Surgery Authors: Yuanjia Zhu, Yasuhiro Shudo, Bharathi Lingala, Y. Joseph Woo Source Type: research

First lung and kidney multi-organ transplant following COVID-19 Infection
As the world responds to the global crisis of the COVID-19 pandemic an increasing number of patients are experiencing increased morbidity as a result of multi-organ involvement. Of these, a small proportion will progress to end-stage lung disease, become dialysis dependent, or both. Herein, we describe the first reported case of a successful combined lung and kidney transplantation in a patient with COVID-19. Lung transplantation, isolated or combined with other organs, is feasible and should be considered for select patients impacted by this deadly disease. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 1, 2021 Category: Transplant Surgery Authors: Brandon A. Guenthart, Aravind Krishnan, Aiman Alassar, Jai Madhok, Monika Kakol, Shari Miller, Sheela Pai Cole, Vidya K. Rao, Natalia Martinez Acero, Charles C. Hill, Cindy Cheung, Ethan C. Jackson, Igor Feinstein, Albert H. Tsai, Joshua J. Mooney, Thomas Tags: Case Anecdotes, Comments and Opinions Source Type: research

The Impact of Donor Sex on Heart Transplantation Outcomes – A Study of Over 60,000 Patients in the United States
The objective of this study was to evaluate the impact of donor sex on heart transplantation outcomes in the United States. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - May 1, 2021 Category: Transplant Surgery Authors: Yuanjia Zhu, Yasuhiro Shudo, Bharathi Lingala, Y. Joseph Woo Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 30, 2021 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 30, 2021 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 30, 2021 Category: Transplant Surgery Source Type: research

Importance of blood pressure control and adequate neurohormonal treatment in LVAD patients: Comment to paper by Tran T. et al.
We read with great interest the recently published article “Right ventricular function and cardiopulmonary performance among patients with heart failure supported by durable mechanical circulatory support devices” from Tran T, et al1. The present study offers unique comprehensive data on the hemodynamics of patients supported with left ventricular assis t devices (LVAD) during a protocolized step-wise cardiopulmonary exercise test. Although the clinical benefits of LVAD support are unquestionable, the improvements in peak exercise capacity are limited by the lack of adaptive capacity of current LVADs and periph...
Source: The Journal of Heart and Lung Transplantation - April 28, 2021 Category: Transplant Surgery Authors: C D íez-López, D Dobarro, J González-Costello Tags: Case Anecdotes, Comments and Opinions Source Type: research

Kinetics of generic tacrolimus in heart transplantation: A cautionary note
This study compared active pharmaceutical ingredient (API) and dissolution kinetics of branded tacrolimus and formulations from three generic manufacturers (Mylan, Dr. Reddy's, Intas) including samples from patients who suffered acute cardiac allograft rejection. Generic samples showed similar API content compared to branded samples with no major impurities. Capsules that underwent uniformity testing had consistent capsule-to-capsule API. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 24, 2021 Category: Transplant Surgery Authors: Zachary J. Il'Giovine, J. Bradley Williams, R. Preston Mason, Samuel C.R. Sherratt, Eileen M. Hsich, Harry Lever, Mandeep R. Mehra, Randall C. Starling Tags: Brief Communication Source Type: research

Cystic Fibrosis Foundation Consensus Statements for the Care of Cystic Fibrosis Lung Transplant Recipients
The objective of this document is to provide recommendations to CF and lung transplant clinicians for the management of perioperative and underlying comorbidities of CFLTRs and the impact of transplantation on these comorbidities. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 24, 2021 Category: Transplant Surgery Authors: Dr. David Newcombe, Pali Shah, Erin Lowery, Cecilia Chaparro, Gary Visner, Sarah E. Hempstead, James Abraham, Zubin Bhakta, Maggie Carroll, Lillian Christon, Lara Danziger-Isakov, Joshua M. Diamond, Erika Lease, Jessica Leonard, Marina Litvin, Ray Poole, Source Type: research

Donor-derived cell-free DNA Accurately Detects Acute Rejection in Lung Transplant Patients, A Multicenter Cohort Study
: Acute rejection, which includes antibody-mediated rejection and acute cellular rejection, is a risk factor for lung allograft loss. Lung transplant patients often undergo surveillance transbronchial biopsies to detect and treat acute rejection before irreversible chronic rejection develops. Limitations of this approach include it's invasiveness and high interobserver variability. We tested the performance of percent donor-derived cell-free DNA (%ddcfDNA), a non-invasive blood test, to detect acute rejection. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 23, 2021 Category: Transplant Surgery Authors: Moon Kyoo Jang, Ilker Tunc, Gerald J. Berry, Charles Marboe, Hyesik Kong, Michael B. Keller, Pali D. Shah, Irina Timofte, Anne W. Brown, Ileana L. Ponor, Cedric Mutebi, Mary C. Philogene, Kai Yu, Aldo Iacono, Jonathan B. Orens, Steven D. Nathan, Sean Agbo Tags: Original Clinical Science Source Type: research

Cystic Fibrosis Foundation Consensus Statements for the Care of Cystic Fibrosis Lung Transplant Recipients
The objective of this document is to provide recommendations to CF and lung transplant clinicians for the management of perioperative and underlying comorbidities of CFLTRs and the impact of transplantation on these comorbidities. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2021 Category: Transplant Surgery Authors: Pali Shah, Erin Lowery, Cecilia Chaparro, Gary Visner, Sarah E. Hempstead, James Abraham, Zubin Bhakta, Maggie Carroll, Lillian Christon, Lara Danziger-Isakov, Joshua M. Diamond, Erika Lease, Jessica Leonard, Marina Litvin, Ray Poole, Fanny Vlahos, Chelse Tags: Consensus Statement Source Type: research

Concomitant bilateral video-assisted thoracoscopic sympathectomy and minimal-invasive left ventricular assist device implantation
We present a novel case of a patient with ICM treated with concomitant bilateral video-assisted thoracoscopic sympathectomy (bVATS) and minimal-invasive LVAD implantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 21, 2021 Category: Transplant Surgery Authors: Michal Nozdrzykowski, Thomas Schroeter, Marcus Sandri, Joanna Jozwiak-Nozdrzykowska, Kerstin Bode, Uwe Schulz, Gerhard Hindricks, Michel A. Borger, Diyar Saeed Tags: Case Anecdotes, Comments, and Opinions Source Type: research

Is tacrolimus by any generic name as sweet?
“What's in a name? That which we call a rose by any other name would smell as sweet1.” Though Shakespeare, no doubt, did not have generic immunosuppression in mind, one can ask a somewhat analogous question regarding equivalence of generic immunosuppression agents to those marketed under the bra nd name. This question was addressed by The International Society for Heart and Lung Transplantation in 20092, around the time generic tacrolimus became available. That document reviewed the process for generic approval, as well as special considerations that may impact medication pharmacokinetics, including dietary int...
Source: The Journal of Heart and Lung Transplantation - April 21, 2021 Category: Transplant Surgery Authors: Adam B. Cochrane, Tara M. Veasey Tags: Editorial Source Type: research

Association of Low Center Performance Evaluations and Pediatric Heart Transplant Center Behavior in the U.S.
To date, no study has evaluated the effects of low center performance evaluations (CPE) on pediatric heart transplant (HT) center behavior. We sought to assess the impact of low CPE flags on pediatric HT center listing and transplant volumes and center recipient and donor characteristics. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 21, 2021 Category: Transplant Surgery Authors: Shahnawaz Amdani, Gerard Boyle, Joseph Rossano, Janet Scheel, Marc Richmond, Susana Arrigain, Jesse D. Schold Tags: Original Clinical Science Source Type: research

Concomitant bilateral video assisted thoracoscopic sympathectomy and minimal-invasive left ventricular assist device implantation
We present a novel case of a patient with ICM treated with concomitant bilateral video assisted thoracoscopic sympathectomy (bVATS) and minimal-invasive LVAD implantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 21, 2021 Category: Transplant Surgery Authors: M. Nozdrzykowski, T. Schroeter, M. Sandri, Jozwiak-Nozdrzykowska Joanna, K Bode, Uwe Schulz, G Hindricks, MA Borger, D Saeed Tags: Case Anecdotes, Comments and Opinions Source Type: research