Patient and disease characteristics of the first 500 patients with pulmonary arterial hypertension treated with selexipag in real-world settings from the sphere registry (selexipag: the users drug registry)
Selexipag is a selective oral prostacyclin-receptor agonist indicated for pulmonary arterial hypertension (PAH) treatment. SelexiPag: tHe usErs dRug rEgistry (SPHERE; NCT03278002) is collecting data from selexipag-treated patients in real-world clinical practice to elucidate and describe the clinical characteristics, outcomes, and dosing/titration regimens of patients treated with selexipag in routine clinical practice. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 14, 2021 Category: Transplant Surgery Authors: Nick H Kim, Anna R Hemnes, Murali M Chakinala, Kristin B Highland, Kelly M Chin, Vallerie McLaughlin, Carol Zhao, Veena Narayan, Harrison W Farber Tags: Original Clinical Science Source Type: research

Hyperbaric oxygen therapy to prevent central airway stenosis after lung transplantation
Central airway stenosis (CAS) is a severe airway complication after lung transplantation associated with bronchial ischemia and necrosis. We sought to determine if hyperbaric oxygen therapy (HBOT), an established treatment for tissue ischemia, attenuates post-transplant bronchial injury. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 14, 2021 Category: Transplant Surgery Authors: Bryan D. Kraft, Kamran Mahmood, Nicole P. Harlan, Matthew G. Hartwig, Laurie D. Snyder, Hagir B. Suliman, Scott L. Shofer Source Type: research

Clinical Features and Prognosis of Surgically Proven Constrictive Pericarditis Following Orthotopic Heart Transplantation
Constrictive pericarditis (CP) results in pericardial noncompliance and diastolic dysfunction. Definitive treatment is pericardiectomy, but data on CP following orthotopic heart transplantation (OHT) are limited. Accordingly, a retrospective review of eight cases of surgically proven CP post-OHT undergoing pericardiectomy was conducted. In this series, all patients were male. Median time to symptomatic CP following OHT was 1.7 years (0.8-18.1 years). Echocardiographic assessment was diagnostic for CP in three cases (38%). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 12, 2021 Category: Transplant Surgery Authors: James W. Lloyd, Jae K. Oh, Richard C. Daly, Robert R. Frantz, John A. Stulak, S. Allen Luis, William R. Miranda Source Type: research

Less invasive surgical implant strategy and right heart failure following LVAD implantation
Conventional median sternotomy (CMS) is still the standard technique utilized to implant left ventricular assist devices (LVAD). Recent studies suggest that less invasive surgery (LIS) may be beneficial; however, robust data on differences in right heart failure (RHF) is lacking. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 11, 2021 Category: Transplant Surgery Authors: Diyar Saeed, Rahatullah Muslem, Moniba Rasheed, Kadir Caliskan, Nikolaos Kalampokas, Firat Sipahi, Artur Lichtenberg, Khalil Jawad, Michael Borger, Simone Huhn, Rebecca Cogswell, Ranjit John, Jessica Schultz, Hirak Shah, Steven Hsu, Nisha A Gilotra, Paul Tags: Original Clinical Science Source Type: research

Reply to “Risk stratification in PH associated with interstitial lung disease: The Holy Grail?”
We thank Beshay and Sahay for their article1 which refers to our recent publication on risk classification in pulmonary hypertension due to interstitial lung disease (ILD-PH).2 (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 11, 2021 Category: Transplant Surgery Authors: Khodr Tello, Athiththan Yogeswaran, Ardeschir Ghofrani, Henning Gall Tags: Case Anecdotes, Comments and Opinions Source Type: research

First 5-year multicentric clinical trial experience with the HeartMate 3 LVAS
The HeartMate 3 (HM3) Left Ventricular Assist System (LVAS) (Abbott, Abbott Park, IL) is a durable mechanical circulatory support device with unique features comprising of a magnetically levitated rotor with wide blood flow path and artificial pulse wave.1 (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 7, 2021 Category: Transplant Surgery Authors: Ivan Netuka, Yuriy Pya, Daniel Zimpfer, Evgenij Potapov, Jens Garbade, Vivek Rao, Michiel Morshuis, Friedhelm Beyersdorf, Silvana Marasco, Poornima Sood, Carlo Gazzola, Jan D. Schmitto Tags: Brief Communication Source Type: research

COVID-19 Vaccination in Our Transplant Recipients: The Time is Now
While the SARS-CoV-2 pandemic has highlighted many of the failings of our healthcare system and society, there has been one spectacular scientific achievement: within a year of the onset of the pandemic, we now have, and can administer vaccines that effectively prevent serious COVID-19. The rapid development of these vaccines has built upon substantive prior vaccine development focused on other pathogens such as Severe Acute Respiratory Syndrome, Middle East Respiratory Syndrome, and Ebola virus. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - January 2, 2021 Category: Transplant Surgery Authors: Saima Aslam, Daniel R. Goldstein, Robin Vos, Andrew E. Gelman, Michelle M. Kittleson, Cameron Wolfe, Lara Danziger-Isakov Source Type: research

Venous or arterial thromboses after venoarterial extracorporeal membrane oxygenation support: Frequency and risk factors
Although venous thrombosis after venovenous –extracorporeal membrane oxygenation (ECMO) is well described, vascular complications occurring after venoarterial ECMO (VA-ECMO) removal have not yet been thoroughly described. Our aim was to evaluate the frequency of vascular (arterial and venous) complications after VA-ECMO removal and try to i dentify the risk factors associated with them. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 29, 2020 Category: Transplant Surgery Authors: Frank Bidar, Aymeric Lancelot, Guillaume Lebreton, Marc Pineton de Chambrun, Matthieu Schmidt, Guillaume H ékimian, Charles Juvin, Nicolas Bréchot, Thibaut Schoell, Pascal Leprince, Alain Combes, Adrien Bouglé, Charles-Edouard Luyt Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Venous or Arterial Thromboses after Venoarterial-Extracorporeal Membrane Oxygenation Support: Frequency and Risk Factors
Although venous thrombosis following venovenous-extracorporeal membrane oxygenation (ECMO) is well described, vascular complications occurring after venoarterial-ECMO (VA-ECMO) removal have not yet been thoroughly described. Our aim was to evaluate the frequency of vascular (arterial and venous) complications after VA-ECMO removal and try to identify risk factors associated with them. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 29, 2020 Category: Transplant Surgery Authors: Frank Bidar, Aymeric Lancelot, Guillaume Lebreton, Marc Pineton de Chambrun, Matthieu Schmidt, Guillaume H ékimian, Charles Juvin, Nicolas Bréchot, Thibaut Schoell, Pascal Leprince, Alain Combes, Adrien Bouglé, Charles-Edouard Luyt Tags: Original Clinical Science Source Type: research

The results of a single-center experience with heartmate 3 in a biventricular configuration
Right ventricular failure after left ventricular assist device (LVAD) implantation is a difficult problem. One solution is implantation of continuous flow ventricular assist devices in a biventricular configuration. Disappointing survival and a concerning incidence of right-sided pump thrombosis has been previously reported. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 28, 2020 Category: Transplant Surgery Authors: David McGiffin, Christina Kure, Janelle McLean, Silvana Marasco, Peter Bergin, James L Hare, Angeline Leet, Hitesh Patel, Adam Zimmet, Julia Rix, Andrew Taylor, David Kaye Tags: Original Clinical Science Source Type: research

Comparison of combined heart-liver versus heart-only transplantation in pediatric and young adult fontan patients
Indications for heart-liver transplantation (HLT) for Fontan patients are not well-defined. We compared listing characteristics, post-operative complications, and post-transplant outcomes of Fontan patients with HLT to those with heart-only transplant (HT). We hypothesized HLT patients have increased post-operative complications, but superior survival outcomes compared to HT patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 28, 2020 Category: Transplant Surgery Authors: Danielle Sganga, Seth A Hollander, Sumeet Vaikunth, Christiane Haeffele, Rachel Bensen, Manchula Navaratnam, Nancy McDonald, Elizabeth Profita, Katsuhide Maeda, Waldo Concepcion, Daniel Bernstein, Sharon Chen Tags: Original Clinical Science Source Type: research

Risk assessment in patients with pulmonary arterial hypertension in the era of COVID 19 pandemic and the telehealth revolution: State of the art review
Patients affected by pulmonary arterial hypertension (PAH) benefit from intensive, continuous clinical monitoring to guide escalation of treatments that carry the potential to improve survival and quality of life. During the coronavirus disease 2019 pandemic, the need for physical distancing has fueled the expeditious expansion of various telehealth modalities, which may apply in a unique manner to individuals with PAH. Performance of objective risk assessments in patients with PAH remotely via telemedical visits and other telehealth mechanisms is unprecedented and not yet rigorously validated. (Source: The Journal of Hear...
Source: The Journal of Heart and Lung Transplantation - December 18, 2020 Category: Transplant Surgery Authors: Michael Wesley Milks, Sandeep Sahay, Raymond L. Benza, Harrison W. Farber Tags: STATE OF ART Source Type: research

Risk assessment in patients with PAH in the era of COVID-19 and the telehealth revolution
Patients affected by pulmonary arterial hypertension (PAH) benefit from intensive, continuous clinical monitoring to guide escalation of treatments that carry the potential to improve survival and quality of life. During the COVID-19 pandemic, the need for physical distancing has fueled the expeditious expansion of various telehealth modalities, which may apply in a unique manner to individuals with PAH. Performance of objective risk assessments in patients with PAH remotely via telemedical visits and other telehealth mechanisms is unprecedented and not yet rigorously validated. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 18, 2020 Category: Transplant Surgery Authors: M. Wesley Milks, Sandeep Sahay, Raymond L. Benza, Harrison W. Farber Tags: State of the art review Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 16, 2020 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 16, 2020 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 16, 2020 Category: Transplant Surgery Source Type: research

Pregnancy after heart transplantation: A second-generation transmission of the gift of life —in reply
Tzatzaki et  al raise several concerns regarding our systematic review and meta-analysis on pregnancy outcomes in women with cardiothoracic transplants.1 (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 14, 2020 Category: Transplant Surgery Authors: Sergio Acuna, Rohan D'Souza Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Pregnancy after heart transplantation: A second-generation transmission of the gift of life – In Reply
Tzatzaki et al raise several concerns regarding our systematic review and meta-analysis on Pregnancy outcomes in women with cardiothoracic transplants1. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 14, 2020 Category: Transplant Surgery Authors: Sergio Acuna, Rohan D'Souza Source Type: research

Beyond the Eyeball Test: Impact and Potential Mechanisms of Frailty in Heart Transplant Candidates
When patients with advanced heart failure are presented to the Heart Transplant Selection Committee, the exhaustive discussion of potential contraindications and suitability for transplantation often boils down to a single question: “Does he pass the eyeball test?” The “eyeball test” is a clinician's gestalt, the unconscious compilation of observation and instinct, that guides many clinical decisions, but should it? Probably not; in assessment of patients undergoing cardiac surgery, the clinician's eyeball test systemic ally overestimated frailty1 and operative risk. (Source: The Journal of Heart an...
Source: The Journal of Heart and Lung Transplantation - December 14, 2020 Category: Transplant Surgery Authors: Sean X. Leng, Michelle M. Kittleson Tags: Editorial Source Type: research

Pregnancy in pulmonary arterial hypertension: Midterm outcomes of mothers and offspring
Before the turn of the century, pregnancy in women with pulmonary arterial hypertension (PAH) was associated with maternal mortality rates of 30% and neonatal mortality rates of 11%.1 In more recent series, despite improved management of PAH, pregnancy-associated maternal mortality remained high, ranging from 11% to 25%.2 –6 As of today, there is no cure for PAH, and case reports have suggested that pregnancy may accelerate disease progression.7 Hence, current pulmonary hypertension guidelines continue to recommend that all patients with PAH avoid pregnancy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 11, 2020 Category: Transplant Surgery Authors: Jan C. Kamp, Constantin von Kaisenberg, Susanne Greve, Lotta Winter, Da-Hee Park, Jan Fuge, Christian K ühn, Marius M. Hoeper, Karen M. Olsson Tags: RESEARCH CORRESPONDENCE Source Type: research

Pregnancy in pulmonary arterial hypertension: Mid-term outcomes of mothers and offspring
Current guidelines recommend that patients with pulmonary arterial hypertension (PAH) avoid pregnancy because of a high mortality risk for the patients and their offspring. Still, some PAH patients become pregnant. We herein report the mid-term maternal and offspring outcomes of 25 consecutive pregnancies in 16 patients with PAH. Five patients had a total of 8 abortions (5 spontaneous, 3 induced; one of these patients developed right ventricular failure and underwent urgent lung transplantation). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 11, 2020 Category: Transplant Surgery Authors: Jan C. Kamp, Constantin von Kaisenberg, Susanne Greve, Lotta Winter, Da-Hee Park, Jan Fuge, Christian K ühn, Marius M. Hoeper, Karen M. Olsson Source Type: research

Bridging the survival gap in cystic fibrosis: An investigation of lung transplant outcomes in Canada and the United States
The objectives of this study were to compare CF transplant outcomes between Canada and the US and estimate the potential contribution of transplantation to the survival gap. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 6, 2020 Category: Transplant Surgery Authors: Anne L. Stephenson, Kathleen J. Ramos, Jenna Sykes, Xiayi Ma, Sanja Stanojevic, Bradley S. Quon, Bruce C. Marshall, Kristofer Petren, Joshua S. Ostrenga, Aliza K. Fink, Albert Faro, Alexander Elbert, Cecilia Chaparro, Christopher H. Goss Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Bridging the survival gap in cystic fibrosis –an investigation of lung transplant outcomes in Canada and the United States.
: Prior literature in cystic fibrosis (CF) has shown a 10-year survival gap between Canada and the US. We hypothesized that differential access to, and survival following lung transplantation may contribute to the observed gap. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 6, 2020 Category: Transplant Surgery Authors: Anne L. Stephenson, Kathleen J. Ramos, Jenna Sykes, Xiayi Ma, Sanja Stanojevic, Bradley S. Quon, Bruce C. Marshall, Kristofer Petren, Joshua S. Ostrenga, Aliza K. Fink, Albert Faro, Alexander Elbert, Cecilia Chaparro, Christopher H. Goss Source Type: research

Ventilation in the prone position improves oxygenation and results in more lungs being transplanted from organ donors with hypoxemia and atelectasis
Hypoxemia is the most common barrier to lungs being transplanted from eligible organ donors who are brain dead (BD). Atelectasis is the principal reversible contributing factor to hypoxemia after brain death. We evaluated prospectively whether ventilation in the prone position in donors who are BD would reverse atelectasis, improve oxygenation, and result in more lungs being transplanted. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 4, 2020 Category: Transplant Surgery Authors: Gary F. Marklin, Coby O'Sullivan, Rajat Dhar Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

A novel method of donor ‒recipient size matching in pediatric heart transplantation: A total cardiac volume‒predictive model
The pediatric heart transplant community uses weight-based donor-to-recipient size matching almost exclusively, despite no evidence to validate weight as a reliable surrogate of cardiac size. Donor size mismatch is the second most common reason for the refusal of donor hearts in current practice ( ∼30% of all refusals). Whereas case-by-case segmentation of total cardiac volume (TCV) by computed tomography (CT) for direct virtual transplantation is an attractive option, it remains limited by the unavailability of donor chest CT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 4, 2020 Category: Transplant Surgery Authors: Nicholas A. Szugye, Farhan Zafar, Nicholas J. Ollberding, Chet Villa, Angela Lorts, Michael D. Taylor, David L.S. Morales, Ryan A. Moore Tags: ORIGINAL PRE-CLINICAL SCIENCE Source Type: research

Prone ventilation improves oxygenation and results in more lungs transplanted in organ donors with hypoxemia and atelectasis
Hypoxemia is the most common barrier to lungs being transplanted from eligible brain-dead (BD) organ donors. Atelectasis is the principal reversible contributing factor to hypoxemia after brain death. We evaluated prospectively whether ventilation of BD donors in the prone position would reverse atelectasis, improve oxygenation, and result in more lungs transplanted. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 4, 2020 Category: Transplant Surgery Authors: Gary F Marklin, Coby O'Sullivan, Rajat Dhar Tags: Original Clinical Science Source Type: research

The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant patients
This study aims to investigate the interrelationship between delays in gastrointestinal motility and the diversity and composition of gastric, oropharyngeal and lung microbiomes in pediatric lung transplant patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 4, 2020 Category: Transplant Surgery Authors: Britta L ötstedt, Debra Boyer, Gary Visner, Dawn Freiberger, Margot Lurie, Madeline Kane, Courtney DiFilippo, Joakim Lundeberg, Monica Narvaez-Rivas, Kenneth Setchell, Eric Alm, Rachel Rosen Tags: Original Clinical Science Source Type: research

A Novel Method of Donor-Recipient Size Matching in Pediatric Heart Transplantation: A Total Cardiac Volume Predictive Model
The pediatric heart transplant community uses weight-based donor to recipient size matching almost exclusively, despite no evidence to validate weight as a reliable surrogate of cardiac size. Donor size mismatch is the second most common reason for refusal of donor hearts in current practice ( ∼30% of all refusals). While case-by-case segmentation of total cardiac volume (TCV) by computed tomography (CT) for direct virtual transplantation is an attractive option, it remains limited by the unavailability of donor chest CT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 4, 2020 Category: Transplant Surgery Authors: Nicholas A. Szugye, Farhan Zafar, Nicholas J. Ollberding, Chet Villa, Angela Lorts, Michael D. Taylor, David L.S. Morales, Ryan A. Moore Source Type: research

Is chronological age still a hard selection criterion for lung transplantation?
As the Western World ages, larger proportions of older people are being listed for lung transplantation. Only within the last two decades, the proportion of lung transplant recipients ≥60 years of age has doubled from 20% to more than 40%1. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 27, 2020 Category: Transplant Surgery Authors: Thomas Schweiger, Konrad Hoetzenecker Tags: Commentary Source Type: research

Outcomes after heart transplantation and total artificial heart implantation: a multicenter study
We sought to assess the outcomes after heart transplantation (HT) of patients supported with a temporary total artificial heart (t-TAH) as bridge to transplant in high-volume centers. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 27, 2020 Category: Transplant Surgery Authors: Michel Carrier, Jaime Moriguchi, Keyur B. Shah, Anelechi C. Anyanwu, Claudius Mahr, Eric Skipper, Mari ève Cossette, Pierre-Emmanuel Noly Tags: Original Clinical Science Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 26, 2020 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 26, 2020 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 26, 2020 Category: Transplant Surgery Source Type: research

Risk stratification in pulmonary hypertension associated with interstitial lung disease: The holy grail?
We read with great enthusiasm the interesting paper by Yogeswaran et  al1 discussing risk stratification in patients with pulmonary hypertension (PH) related to interstitial lung disease (ILD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 26, 2020 Category: Transplant Surgery Authors: Sarah Beshay, Sandeep Sahay Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Risk stratification in PH associated with interstitial lung disease: The Holy Grail?
We read with great enthusiasm the interesting paper by Yogeswaran et al. discussing risk stratification in patients with pulmonary hypertension (PH) related to interstitial lung disease (ILD)1. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 26, 2020 Category: Transplant Surgery Authors: Sarah Beshay, Sandeep Sahay Tags: Case Anecdotes, Comments and Opinions Source Type: research

Bronchiolitis obliterans syndrome is associated with increased senescent lymphocytes in the small airways
Immunosuppression therapy is ineffective at preventing bronchiolitis obliterans syndrome (BOS), primarily a disease of the small airways (SAs). Our previous reports show increased senescent CD28null T and natural killer T (NKT)-like cells in the peripheral blood of patients with BOS and increased cytotoxic, proinflammatory lymphocytes in the SAs. We hypothesized that the cytotoxic, proinflammatory lymphocytes in the SAs would be steroid-resistant senescent CD28null lymphocytes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 24, 2020 Category: Transplant Surgery Authors: Greg Hodge, Sandra Hodge, Hong Liu, Phan Nguyen, Chien-Li Holmes-Liew, Mark Holmes Tags: ORIGINAL PRE-CLINICAL SCIENCE Source Type: research

BOS is associated with increased senescent lymphocytes in the small airways
Immunosuppression therapy is ineffective at preventing bronchiolitis obliterans syndrome (BOS), primarily a disease of the small airways. Our previous reports show increased senescent CD28null T and NKT-like cells in the peripheral blood in patients with BOS and increased cytotoxic pro-inflammatory lymphocytes in the small airways. We hypothesized that the cytotoxic pro-inflammatory lymphocytes in the small airways would be steroid resistant senescent CD28null lymphocytes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 24, 2020 Category: Transplant Surgery Authors: Greg Hodge, Sandra Hodge, Hong Liu, Phan Nguyen, CL Holmes-Liew, Mark Holmes Tags: Original Pre-Clinical Science Source Type: research

Right ventricular function and cardiopulmonary performance among patients with heart failure supported by durable mechanical circulatory support devices
Patients with continuous-flow left ventricular assist devices (CF-LVADs) experience limitations in functional capacity and frequently, right ventricular (RV) dysfunction. We sought to characterize RV function in the context of global cardiopulmonary performance during exercise in this population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 22, 2020 Category: Transplant Surgery Authors: Tomio Tran, Akshay Muralidhar, Kendall Hunter, Cullen Buchanan, Greg Coe, Michinari Hieda, Christine Tompkins, Matthew Zipse, Melanie J. Spotts, Stephanie G. Laing, Kristina Fosmark, Jordan Hoffman, Amrut V. Ambardekar, Eugene E. Wolfel, Justin Lawley, Be Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Right ventricular function and cardiopulmonary performance among heart failure patients supported by durable mechanical circulatory support devices
Patients with continuous-flow (CF) left ventricular assist devices (LVAD) experience limitations in functional capacity and frequently, right ventricular (RV) dysfunction. We sought to characterize RV function in the context of global cardiopulmonary performance during exercise in this population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 22, 2020 Category: Transplant Surgery Authors: Tomio Tran, Akshay Muralidhar, Kendall Hunter, Cullen Buchanan, Greg Coe, Michinari Hieda, Christine Tompkins, Matthew Zipse, Melanie J Spotts, Stephanie G. Laing, Kristina Fosmark, Jordan Hoffman, Amrut V Ambardekar, Eugene E. Wolfel, Justin Lawley, Benj Tags: Original Clinical Science Source Type: research

Impact of Cytomegalovirus Infection on Gene Expression Profile in Heart Transplant Recipients
: Cytomegalovirus (CMV) infection has been implicated in the pathogenesis of allograft rejection in heart transplant (HT) recipients. The effect of a CMV infection on the gene expression profile (GEP, AlloMap) scores in the absence of acute rejection is not known. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 21, 2020 Category: Transplant Surgery Authors: Manreet K Kanwar, Kiran K Khush, Sean Pinney, Claire Sherman, James Fleming, Shelley Hall, Jeffrey Teuteberg, Nir Uriel, Jon Kobashigawa Source Type: research

The impact of frailty on mortality after heart transplantation
Frailty is prevalent in patients with advanced heart failure however its impact on clinical outcomes after heart transplantation is unclear. The aim of this study was to assess the impact of pre-transplant frailty on mortality and the duration of hospitalisation after heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 21, 2020 Category: Transplant Surgery Authors: Peter S Macdonald, Natasha Gorrie, Xavier Brennan, Samira R Aili, Ricardo De Silva, Sunita R Jha, Rodrigo Fritis-Lamora, Elyn Montgomery, Kay Wilhelm, Rachel Pierce, Fiona Lam, Christopher Hayward, Andrew Jabbour, Eugene Kotlyar, Kavitha Muthiah, Anne M K Source Type: research

Right ventricular area strain from 3-dimensional echocardiography: Mechanistic insight of right ventricular dysfunction in pediatric pulmonary hypertension
Right ventricular (RV) function is a major contributor to the outcome of pulmonary arterial hypertension (PAH). Adult studies demonstrated that regional and global changes in RV deformation are prognostic in PAH using 3-dimensional echocardiography (3DE). However, regional and global dynamic changes in RV mechanics have not been described in pediatric PAH. We compared 3DE RV regional and global deformation between pediatric patients who had associated PAH with congenital heart disease (APAH-CHD), pediatric patients who had idiopathic PAH (IPAH), and normal controls, and evaluated the clinical outcomes. (Source: The Journal...
Source: The Journal of Heart and Lung Transplantation - November 14, 2020 Category: Transplant Surgery Authors: Pei-Ni Jone, Nicolas Duchateau, Zhaoxing Pan, D. Dunbar Ivy, Pamela Moceri Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Response to Badagliacca et  al: Multi-dimensional assessment and cluster analysis for idiopathic pulmonary arterial hypertension phenotyping
We thank our colleagues for their thoughtful comments. As the field is moving forward, it becomes increasingly clear that the term idiopathic pulmonary arterial hypertension does not describe a homogenous and well-defined disease but a basket full of pulmonary vascular disorders that do not have much more in common than the presence of pre-capillary pulmonary hypertension and the absence of causative factors. Our cluster analysis focused on demographics and clinical presentation but has implications for disease mechanisms, treatment, and outcome. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 14, 2020 Category: Transplant Surgery Authors: Marius M. Hoeper, Matthias Held Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Letter in response to Badagliacca et al., Multi-dimensional assessment and cluster analysis for idiopathic pulmonary arterial hypertension phenotyping (JHLT-D-20-00956)
We thank our colleagues for their thoughtful comments. As the field is moving forward, it becomes increasingly clear that the term idiopathic pulmonary arterial hypertension (IPAH) does not describe a homogenous and well-defined disease but a basket full of pulmonary vascular disorders that have not much more in common than the presence of pre-capillary pulmonary hypertension and the absence of causative factors. Our cluster analysis focused on demographics and clinical presentation but has implications for disease mechanisms, treatment and outcome. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 14, 2020 Category: Transplant Surgery Authors: Marius M. Hoeper, Matthias Held Tags: Case Anecdotes, Comments and Opinions Source Type: research

Right Ventricular Area Strain from 3D Echocardiography: Mechanistic Insight of Right Ventricular Dysfunction in Pediatric Pulmonary Hypertension
: Right ventricular (RV) function is a major contributor to the outcome of pulmonary arterial hypertension (PAH). Adult studies demonstrated that regional and global changes in RV deformation are prognostic in PAH using three-dimensional echocardiography (3DE). However, regional and global dynamic changes in RV mechanics have not been described in pediatric PAH. We compared 3DE RV regional and global deformation between PAH with congenital heart disease (APAH-CHD), idiopathic pulmonary arterial hypertension (IPAH), and normal controls, and evaluated for clinical outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 14, 2020 Category: Transplant Surgery Authors: Pei-Ni Jone, Nicolas Duchateau, Zhaoxing Pan, D. Dunbar Ivy, Pamela Moceri Source Type: research

Improved survival after heart transplantation in patients bridged with extracorporeal membrane oxygenation in the new allocation system
Historically, patients bridged on extracorporeal membrane oxygenation (ECMO) to heart transplantation (HT) have very high post-transplant mortality. In the new heart transplant allocation system, ECMO-supported patients have the highest priority for HT. However, data are lacking on the outcomes of these critically ill patients. We compared the waitlist and post-transplant outcomes of ECMO-supported patients in the new and old allocation systems. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 8, 2020 Category: Transplant Surgery Authors: Matthew H. Gonzalez, Deepak Acharya, Sangjin Lee, Marzia Leacche, Theodore Boeve, Nabin Manandhar-Shrestha, Stefan Jovinge, Renzo Y. Loyaga-Rendon Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Improved survival after heart transplantation in patients bridged with ecmo in the new allocation system
Historically, patients bridged on extracorporeal membrane oxygenation (ECMO) to heart transplantation (HT) have very high post-transplant mortality. In the new HT allocation system, ECMO supported patients have the highest priority for HT. However, data is lacking on outcomes of these critically ill patients. We compared waitlist and post-transplant outcomes of ECMO supported patients in the new and old allocation systems. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 8, 2020 Category: Transplant Surgery Authors: Matthew H. Gonzalez, Deepak Archarya, Sangjin Lee, Marzia Leacche, Theodore Boeve, Nabin Manandhar Shrestha, Stefan Jovinge, Renzo Y. Loyaga-Rendon Tags: Original Clinical Science Source Type: research

Multidimensional assessment and cluster analysis for idiopathic pulmonary arterial hypertension phenotyping
We read with great interest the cluster analysis from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA) registry1 to identify different phenotypes among patients with idiopathic pulmonary arterial hypertension (PAH) (IPAH). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 7, 2020 Category: Transplant Surgery Authors: Roberto Badagliacca, Silvia Papa, Franz Rischard Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Multi-dimensional assessment and cluster analysis for idiopathic pulmonary arterial hypertension phenotyping
We read with great interest the cluster analysis from the COMPERA registry (1) to identify different phenotypes among idiopathic pulmonary arterial hypertension patients (IPAH). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 7, 2020 Category: Transplant Surgery Authors: Roberto Badagliacca, Silvia Papa, Franz Rischard Tags: Case Anecdotes, Comments and Opinions Source Type: research

Methane supplementation improves graft function in experimental heart transplantation
: Maintenance of cell viability during cold storage is a key issue in organ transplantation. Methane (CH4) bioactivity has recently been recognised in ischaemia/reperfusion conditions; we therefore hypothesised that cold storage in CH4-enriched preservation solution can provide an increased defence against organ dysfunction during experimental heart transplantation (HTX). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 7, 2020 Category: Transplant Surgery Authors: K álmán Benke, Dávid Kurszán Jász, Ágnes Lilla Szilágyi, Bálint Baráth, Eszter Tuboly, Anett Roxána Márton, Petra Varga, Árpád Mohácsi, Anna Szabó, Zsófia Széll, Mihály Ruppert, Tamás Radovits, Gábor Szabó, Béla Merkely, Petra Hartma Source Type: research