“Cocaine Use in Heart Transplant Donors: A Call to Expand the Donor Pool”
The number of patients surviving to stage D heart failure has been increasing, while the supply of donor hearts has remained relatively stable.1-2 Importantly, cardiac allografts from extended-criteria donors, such as those with history of cocaine use, are frequently discarded due to concern over organ quality. Cocaine use particularly raises concerns for cardiac complications including risk of myocardial ischemia, coronary artery vasospasm, myocarditis, and arrhythmias.3 Prior data however, suggests that use of donors with cocaine use does not result in worse outcomes after heart transplantation, though longer-term data r...
Source: The Journal of Heart and Lung Transplantation - September 23, 2020 Category: Transplant Surgery Authors: Donya Mohebali, Jon A. Kobashigawa Tags: Editorial Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 22, 2020 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 22, 2020 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 22, 2020 Category: Transplant Surgery Source Type: research

Transcriptome-based Diagnostics for Chronic Lung Allograft Dysfunction: A Socratic Question Revisited
Current diagnostics in lung transplantation are not meeting our patients ’ needs. While we can identify phenotypes of acute rejection, such as perivascular (A-grade), bronchiolar (B-grade), and antibody-mediated rejection, the link between these pathologies and chronic lung allograft dysfunction (CLAD) is clear only for the more severe cases (1). Most lung transplant r ecipients go on to develop CLAD without clear warning (2). Moreover, interrater reliability for acute rejection pathologies is low (3). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 22, 2020 Category: Transplant Surgery Authors: John Greenland Tags: Editorial Source Type: research

MitraClip in Secondary Mitral Regurgitation as a Bridge to Heart Transplantation: 1-year Outcomes from the International MitraBridge Registry
Patients awaiting heart transplantation (HTx) often need bridging therapies to reduce worsening and progression of underlying disease. Limited data are available regarding the use of the MitraClip procedure in secondary mitral regurgitation for this clinical condition. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 16, 2020 Category: Transplant Surgery Authors: Cosmo Godino, Andrea Munaf ò, Andrea Scotti, Rodrigo Estévez-Loureiro, Antonio Portolés Hernández, Dabit Arzamendi, Estefanía Fernández Peregrina, Maurizio Taramasso, Neil P. Fam, Edwin C. Ho, Anita Asgar, Giancarlo Vitrella, Claudia Raineri, Marian Tags: Original Clinical Science Source Type: research

Transcatheter Mitral Valve Intervention in Advanced Heart Failure
Unlike the taxonomy of cardiac valves based on location (pulmonary or aortic) or leaflet number (tricuspid), the mitral valve designation is an iconic one. Vesalius recognized the sheer complexity of this valve apparatus and chose to brand it after a bishop's headgear, the mitre, due to its likeness.1 Characteristically, physiological competence of the mitral valve is dependent on the competitive intersection of 5 distinct factors. These include an interplay between a) left atrial size (and possibly function), b) left ventricular dilation and contractile performance, c) chordal tendons and papillary muscle alignment, integ...
Source: The Journal of Heart and Lung Transplantation - September 16, 2020 Category: Transplant Surgery Authors: Mandeep R. Mehra, Maria Rosa Costanzo Source Type: research

Azithromycin prophylaxis after lung transplant is associated with improved overall survival
Azithromycin prophylaxis (AP) in lung transplant recipients has been shown to reduce the composite endpoint of death or chronic lung allograft dysfunction (CLAD) onset but without a clear effect on overall survival. Our program began using AP in 2010. We sought to evaluate the association between AP and survival, the risk of CLAD and baseline lung allograft dysfunction (BLAD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 16, 2020 Category: Transplant Surgery Authors: David Li, Qiuli Duan, Justin Weinkauf, Ali Kapasi, Rhea Varughese, Alim Hirji, Dale Lien, Steven Meyer, Bryce Laing, Jayan Nagendran, Kieran Halloran Tags: Original Clinical Science Source Type: research

Recombinant Herpes Zoster Vaccine after Heart Transplantation: A Single Center Experience
Herpes zoster (HZ) results from reactivation of latent varicella zoster virus (VZV) often manifesting as a dermatomal rash leading to complications including post-herpetic neuralgia. It occasionally can be in multiple dermatomes or systemic.1 Diminished cellular immunity to VZV increases HZ risk.2 Solid organ transplant (SOT) recipients have a mixed, mainly cellular immune deficit due to chronic immunosuppression. HZ incidence in SOT is 9 times higher than the general population (22-28 vs 3-5/1000 person-years) and they are at increased risk for severe manifestations of HZ. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 9, 2020 Category: Transplant Surgery Authors: Maya H Barghash, Sarah Taimur, Meenakshi Rana, Jessica Behar, Donna M Mancini Tags: Research Correspondence Source Type: research

Donor-Specific Antibody Characteristics Including Persistence and Complement-Binding Capacity Increase Risk for Chronic Lung Allograft Dysfunction
Chronic Lung Allograft Dysfunction (CLAD) is the major complication limiting long-term survival in lung transplant recipients (LTRs), with those developing donor-specific anti-HLA antibodies (DSA) previously found to have increased risk for CLAD. However, as DSA responses vary in timing of development, specificity, breadth, persistence and complement-binding capacity, we hypothesized that these characteristics would impact CLAD and survival outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 9, 2020 Category: Transplant Surgery Authors: Carlo J. Iasella, Christopher R. Ensor, Marilyn Marrari, Massimo Mangiola, Qingyong Xu, Eric Nolley, Cody A. Moore, Matthew R. Morrell, Joseph M. Pilewski, Pablo G. Sanchez, John F. McDyer, Adriana Zeevi Source Type: research

The curious phenomenon of early cardiac allograft rejection with hepatitis C ‒infected donor heart transplants
In recent years, emerging data have demonstrated that organs from donors infected with hepatitis C virus (HCV) can be transplanted into uninfected recipients with excellent outcomes. Critical to this success is the use of pre-emptive or prophylactic direct-acting anti-viral (DAA) therapy, with the intent to minimize any viral transmission and block viral replication. The optimal timing to employ such therapy, whether at the time of transplantation or after the detection of viremia, remains a matter of ongoing debate. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 7, 2020 Category: Transplant Surgery Authors: Ann E. Woolley, Steve K. Singh Tags: EDITORIAL COMMENTARY Source Type: research

The Curious Phenomenon of Early Cardiac Allograft Rejection with Hepatitis C Infected Donor Heart Transplants
In recent years, emerging data has demonstrated that organs from Hepatitis C Virus (HCV)-infected donors can be transplanted into uninfected recipients with excellent outcomes. Critical to this success is the use of pre-emptive or prophylactic direct-acting antiviral (DAA) therapy, with the intent to minimize any viral transmission and block viral replication. The optimal timing to employ such therapy, whether at the time of transplant or following the detection of viremia, remains a matter of ongoing debate. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 7, 2020 Category: Transplant Surgery Authors: Ann E. , Woolley, Steve K. Singh Tags: Editorial Source Type: research

Preservation by cold storage vs ex vivo normothermic perfusion of marginal donor hearts: clinical, histopathological and ultrastructural features.
To match clinical outcomes of heart transplantation against histopathological and ultrastructural characteristics of marginal grafts preserved by cold storage or ex vivo normothermic perfusion. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 3, 2020 Category: Transplant Surgery Authors: Sandro Sponga, Antonella Bonetti, Veronica Ferrara, Antonio Paolo Beltrami, Miriam Isola, Igor Vendramin, Nicoletta Finato, Fulvia Ortolani, Ugolino Livi Tags: Original Clinical Science Source Type: research

Consequences of functional mitral regurgitation and atrial fibrillation in patients with left ventricular assist devices
This study aimed to investigate the characteristics and prognostic significance of FMR and AF in patients with LVADs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 3, 2020 Category: Transplant Surgery Authors: Hideyuki Hayashi, Yoshifumi Naka, Joseph Sanchez, Hiroo Takayama, Paul Kurlansky, Yuming Ning, Veli K Topkara, Melana Yuzefpolskaya, Paolo C Colombo, Gabriel T Sayer, Nir Uriel, Koji Takeda Tags: Original Clinical Science Source Type: research

Durable mechanical circulatory support across the Asia-Pacific region
The Asia region consists of 48 countries with a population of 3.8 billion and extends from Saudi Arabia and Turkey in the west to the most eastern part of Russia. The Asia-Pacific region includes East Asia, South Asia, Southeast Asia, and Oceania. It extends from Pakistan in the west to Japan, Australia, and New Zealand in the east.1 Accurate data from Asia on heart transplantation is lacking as not all centers report their data to the International Society for Heart and Lung Transplantation (ISHLT) registry. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 2, 2020 Category: Transplant Surgery Authors: Cumaraswamy Sivathasan, Christopher Hayward, Paul Jansz, Amul Kumar Sibal, ChenChen, Ho Ka Lai Cally, Komarakshi Rajagopalan Balakrishnan, Yang Hyun Cho, Mohd Nazeri Nordin, Joseph B. Barril, Feras Khaliel, Mandeep R. Mehra Tags: EDITORIAL COMMENTARY Source Type: research

Use of Sacubitril-Valsartan in Blood Pressure Control with Left Ventricular Assist Devices
Blood pressure control is a cornerstone in management of patients supported with a Left Ventricular Assist Device (LVAD) [1]. Adequate blood pressure control, with a target of mean blood pressure (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 2, 2020 Category: Transplant Surgery Authors: David Dobarro, Carles Diez-L ópez, David Couto-Mallón, Javier Castrodeza, Manuel Gómez-Bueno, Javier Tobar, Antonio Gonçalves, Maria Melendo-Viu, Scott McKenzie, Carlos Ortiz, Jose González-Costello Tags: Research Correspondence Source Type: research

Durable Mechanical Circulatory Support Across the Asia Pacific Region
The Asia region consists of 48 countries with a population of 3.8 billion, extends from Saudi Arabia and Turkey in the west to the most eastern part of Russia. Asia-Pacific includes East Asia, South Asia, Southeast Asia, and Oceania. It extends from Pakistan in the west to Japan, Australia and New Zealand in the east1. Accurate data from Asia on heart transplantation is lacking as not all centers report their data to ISHLT registry. According to the Global Observatory on Donation and Transplantation (GODT), less than 0.4 heart transplants per million population are performed yearly compared to more than 7.5 per million in ...
Source: The Journal of Heart and Lung Transplantation - September 2, 2020 Category: Transplant Surgery Authors: Cumaraswamy Sivathasan, Christopher Hayward, Paul Jansz, Amul Kumar Sibal, Chen Chen, Ho Ka Lai Cally, Komarakshi Rajagopalan Balakrishnan, Yang Hyun Cho, Mohd.Nazeri Nordin, Joseph B. Barril, Feras Khaliel, Mandeep R. Mehra Tags: EDITORIAL Source Type: research

Cocaine use in organ donors and long-term outcome after heart transplantation: An International Society for Heart and Lung Transplantation registry analysis
Cardiac allografts from donors with a history of cocaine use (DHCU) are often discarded owing to concerns regarding organ quality. We investigated long-term outcomes of de novo adult heart transplantation (HTx) using DHCU. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 1, 2020 Category: Transplant Surgery Authors: Jefferson L. Vieira, Wida S. Cherikh, Kelsi Lindblad, Josef Stehlik, Mandeep R. Mehra Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 1, 2020 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 1, 2020 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 1, 2020 Category: Transplant Surgery Source Type: research

Cocaine Use in Organ Donors and Long-Term Outcome After Heart Transplantation: An ISHLT Registry Analysis
Cardiac allografts from donors with a history of cocaine use (DHCU) are often discarded due to concerns regarding organ quality. We investigated long-term outcomes of de-novo adult heart transplantation (HTx) using DHCU. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 1, 2020 Category: Transplant Surgery Authors: Jefferson L. Vieira, Wida S. Cherikh, Kelsi Lindblad, Josef Stehlik, Mandeep R. Mehra Tags: Original Clinical Science Source Type: research

Successful transplantation of high-risk cardiac allografts from DCD donors following ex-vivo coronary angiography
Despite increased use of marginal donor hearts including the utilization of donation after circulatory death (DCD) allografts, there remains a global paucity of donors to match the burgeoning waiting lists. The pressures of an aging population have led to the necessary acceptance of older donors with higher risk profiles for coronary artery disease (CAD).1 A lack of facilities or time constraints on the donor workup may preclude coronary angiography on such donors. In addition, in the DCD setting, coronary angiography is often refused on ethical and/or legal grounds. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - September 1, 2020 Category: Transplant Surgery Authors: James Nadel, Sarah Scheuer, Krishna Kathir, David Muller, Paul Jansz, Peter Macdonald Tags: Research Correspondence Source Type: research

Pig Kidney Xenotransplantation: Progress Towards Clinical Trials
Pig organ xenotransplantation offers a solution to the shortage of deceased human organs for transplantation. The pathobiological response to a pig xenograft is complex, involving antibody, complement, coagulation, inflammatory, and cellular responses. To overcome these barriers, genetic manipulation of the organ-source pigs has largely been directed to two major aims – (i) deletion of expression of the known carbohydrate xenoantigens against which humans have natural (preformed) antibodies, and (ii) transgenic expression of human protective proteins, e.g., complement- and coagulation-regulatory proteins. (Source: Th...
Source: The Journal of Heart and Lung Transplantation - August 29, 2020 Category: Transplant Surgery Authors: David K.C. Cooper, Hidetaka Hara, Hayato Iwase, Takayuki Yamamoto, Zheng-Yu Wang, Abhijit Jagdale, Mohamed H. Bikhet, Huy Q. Nguyen, Jeremy B. Foote, Wayne D. Paris, David Ayares, Vineeta Kumar, Douglas J. Anderson, Jayme E. Locke, Devin E. Eckhoff Tags: Review Source Type: research

Hemodynamics and risk assessment 2 years after the initiation of upfront ambrisentan ‒tadalafil in pulmonary arterial hypertension
Upfront combination therapy with ambrisentan and tadalafil has been reported to improve the condition of patients with pulmonary arterial hypertension (PAH) more than with either drug alone. However, little is known about the long-term associated changes in hemodynamics and risk assessment scores. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 28, 2020 Category: Transplant Surgery Authors: Michele D'Alto, Roberto Badagliacca, Francesco Lo Giudice, Paola Argiento, Gavino Casu, Marco Corda, Michele Correale, Stefano Ghio, Alessandra Greco, Mariangela Lattanzio, Valentina Mercurio, Giuseppe Paciocco, Silvia Papa, Renato Prediletto, Emanuele Ro Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Geographic and temporal patterns of growth in the utilization of donation after circulatory death donors for lung transplantation in the United States
Universal identification and referral of donation after circulatory death (DCD) lung donors could increase the supply of transplantable lungs by up to 50%.1 Transplanting lungs from DCD donors has gained further interest because recent studies have demonstrated comparable short-term and long-term survival outcomes between recipients of DCD and non-DCD donor lungs.2,3 However, the growth of DCD donor utilization may not be uniformly distributed across geographic regions in the United States, raising potential concerns about access and quality of care. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 28, 2020 Category: Transplant Surgery Authors: Sameer A. Hirji, Alison L. Halpern, Laura J. Helmkamp, Sophia H. Roberts, Anna K. Houk, Asishana Osho, Alexis K. Okoh, Robert A. Meguid, Laura Seese, Michael J. Weyant, Daniel E. Rinewalt Tags: RESEARCH CORRESPONDENCE Source Type: research

Geographic and temporal patterns of growth in utilization of donation after circulatory death donors for lung transplantation in the united states
Universal identification and referral of donation after circulatory death (DCD) lung donors could increase the supply of transplantable lungs by up to 50%.1 Transplanting lungs from DCD donors has gained further interest as recent studies have demonstrated comparable short-term and long-term survival outcomes between recipients of DCD and non-DCD donor lungs.2-3 However, the growth of DCD donor utilization may not be uniformly distributed across geographic regions in the United States, raising potential concerns about access and quality of care. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 28, 2020 Category: Transplant Surgery Authors: Sameer A. Hirji, Alison L. Halpern, Laura J. Helmkamp, Sophia H. Roberts, Anna K. Houk, Asishana Osho, Alexis K. Okoh, Robert A. Meguid, Laura Seese, Michael J. Weyant, Daniel E. Rinewalt Tags: Research Correspondence Source Type: research

Hemodynamics and risk assessment two years after initiation of upfront ambrisentan-tadalafil in pulmonary arterial hypertension
- Upfront combination therapy with ambrisentan and tadalafil has been reported to improve pulmonary arterial hypertension (PAH) patients more than with either drug alone. However, little is known about long-term associated changes in hemodynamics and risk assessment scores. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 28, 2020 Category: Transplant Surgery Authors: Michele D'Alto, Roberto Badagliacca, Francesco Lo Giudice, Paola Argiento, Gavino Casu, Marco Corda, Michele Correale, Stefano Ghio, Alessandra Greco, Mariangela Lattanzio, Valentina Mercurio, Giuseppe Paciocco, Silvia Papa, Renato Prediletto, Emanuele Ro Tags: Original Clinical Science Source Type: research

Molecular T-cell ‒mediated rejection in transbronchial and mucosal lung transplant biopsies is associated with future risk of graft loss
This study aimed to develop molecular assessments for TBBs and mucosal biopsies and to establish the impact of molecular TCMR on graft survival . (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 26, 2020 Category: Transplant Surgery Authors: Kieran Halloran, Michael D. Parkes, Irina Timofte, Gregory Snell, Glen Westall, Jan Havlin, Robert Lischke, Ramsey Hachem, Daniel Kreisel, Deborah Levine, Bartosz Kubisa, Maria Piotrowska, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Alim Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Platelet activation after withdrawal of life support in donation after circulatory death donors
Donation after circulatory death (DCD) heart transplantation is gaining widespread acceptance as an additional pathway for donor heart procurement, with excellent short- and mid-term results reported by high-volume centers in Australia and the United Kingdom.1,2 Because of the obligatory warm ischemic time to which all the DCD allografts are exposed, the establishment of the first successful adult DCD with distant procurement program in 2014 was dependent on both the development of pharmacologic conditioning agents to mitigate myocardial injury and an ex situ perfusion system to minimize ongoing ischemia as well as provide...
Source: The Journal of Heart and Lung Transplantation - August 26, 2020 Category: Transplant Surgery Authors: Sarah E. Scheuer, Claudio Soto, Joanne Joseph, Paul C. Jansz, Peter S. Macdonald Tags: RESEARCH CORRESPONDENCE Source Type: research

Platelet activation following withdrawal of life support in donation after circulatory death donors
Donation after circulatory death (DCD) heart transplantation is gaining widespread acceptance as an additional pathway for donor heart procurement, with excellent short- and mid-term results reported by high-volume centres in Australia and the UK [1, 2]. Due to the obligatory warm ischemic time (WIT) to which all DCD allografts are exposed, the establishment of the first successful adult DCD with distant procurement program in 2014 was dependent on both the development of pharmacological conditioning agents to mitigate myocardial injury, as well as an ex-situ perfusion system to minimise ongoing ischemia and provide a plat...
Source: The Journal of Heart and Lung Transplantation - August 26, 2020 Category: Transplant Surgery Authors: Sarah E Scheuer, Claudio Soto, Joanne Joseph, Paul C Jansz, Peter S Macdonald Tags: Research Correspondence Source Type: research

Longitudinal lung function measurements in single lung transplant recipients with chronic lung allograft dysfunction
Phenotyping chronic lung allograft dysfunction (CLAD) in single lung transplant (SLTX) recipients is challenging. The aim of the study was to assess the diagnostic and prognostic value of longitudinal lung function tests in SLTX recipients with CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 26, 2020 Category: Transplant Surgery Authors: Gabriela Leuschner, Michael Lauseker, Anne-Sophie Howanietz, Katrin Milger, Tobias Veit, Dieter Munker, Christian Schneider, Thomas Weig, Sebastian Michel, J ürgen Barton, Bruno Meiser, Julien Dinkel, Claus Neurohr, Jürgen Behr, Nikolaus Kneidinger Tags: Original Clinical Science Source Type: research

Molecular T cell-mediated rejection in transbronchial and mucosal lung transplant biopsies is associated with future risk of graft loss
We previously developed molecular assessment systems for lung transplant transbronchial biopsies (TBBs) with high surfactant and bronchial mucosal biopsies, identifying T cell-mediated rejection (TCMR) based on expression of rejection-associated transcripts, but the relationship of rejection to graft loss is unknown. The present study aimed to develop molecular assessments for TBBs and mucosal biopsies and to establish the impact of molecular TCMR on graft survival. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 26, 2020 Category: Transplant Surgery Authors: Kieran M Halloran, Michael D Parkes, Irina Timofte, Gregory Snell, Glen Westall, Jan Havlin, Robert Lischke, Ramsey Hachem, Daniel Kreisel, Deborah Levine, Bartosz Kubisa, Maria Piotrowska, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Ali Tags: Original Clinical Science Source Type: research

Cytomegalovirus replication is associated with enrichment of distinct γδ T cell subsets following lung transplantation: A novel therapeutic approach?
Antiviral treatments to control cytomegalovirus (CMV) following lung transplantation (LTx) are associated with toxicity and antiviral resistance. Cellular immunotherapy with virus-specific cytotoxic T cells have yielded promising results but requires donor/recipient matching. Gamma delta ( γδ) T cells are involved in antiviral immunity and can recognize antigens independently of major histocompatibility complex (MHC) and may not require the same level of matching. We assessed the phenotype of circulating γδ T cells following LTx to identify candidate populations for CMV immunother apy. (Source: The ...
Source: The Journal of Heart and Lung Transplantation - August 26, 2020 Category: Transplant Surgery Authors: Sanda Stankovic, Martin S. Davey, Evangeline M. Shaw, Anouk von Borstel, Yvonne Cristiano, Bronwyn J. Levvey, Jamie Rossjohn, Glen P. Westall, Gregory I. Snell, Andrew G. Brooks, Lucy C. Sullivan Tags: Original Pre-Clinical Science Source Type: research

Hemostasis during extracorporeal membrane oxygenation: More questions
We read the study by Durila et  al1 with interest; however, we seek several clarifications. First, a separate study by Yu et al2 showed that the results of platelet function analyzer 200 (PFA 200) are influenced by various factors, such as the use of aspirin and other non-steroidal anti-inflammatory agents, blood group type, he matocrit and time of blood collection, transfusions, and underlying diseases. The severity of surgery might cause bleeding, which affects collagen–epinephrine and collagen–adenosine diphosphate. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 25, 2020 Category: Transplant Surgery Authors: Lin Chen, Zhongheng Zhang, Kun Chen Tags: CASE ANECDOTE, COMMENTS AND OPINIONS Source Type: research

Hemostasis During Extra Corporeal Membrane Oxygenation: More Questions
We read with the study by Durila et al with interest, however seek several clarifications.1 First, a separate study by Yu et al2 showed that the results of platelet function analyzer 200 (PFA-200) is influenced by various factors, such as use of aspirin and other non-steroidal anti-inflammatory agents, blood group type, hematocrit, and time of blood collection, transfusions and underlying diseases. The severity of surgery might cause bleeding which affects collagen −epinephrine (COL/EPI) and collagen−adenosine diphosphate(COL/ADP). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 25, 2020 Category: Transplant Surgery Authors: Lin Chen, Zhongheng Zhang, Kun Chen Tags: Case Anecdotes, Comments and Opinions Source Type: research

Outcomes in the 2018 UNOS Donor Heart Allocation System: A Perspective on Disparate Analyses
“You can't always get what you want ...But if you try sometimes, well, you might find you get what you need"Sir Michael Philip (Mick) Jagger, English singer, songwriter (1943–) (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 25, 2020 Category: Transplant Surgery Authors: Anubodh S. Varshney, Sameer A. Hirji, Michael M. Givertz Tags: Perspective Source Type: research

High-intensity interval training in patients with left ventricular assist devices: A pilot randomized controlled trial
Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure. To date, studies evaluating the impact of aerobic training in patients with LVADs have focused on moderate-intensity exercise. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 20, 2020 Category: Transplant Surgery Authors: Ignacio Moreno-Suarez, Anna Scheer, Kaitlyn Lam, Lawrence Dembo, Angela L. Spence, Christopher Hayward, David M. Kaye, Angela Leet, Louise M. Fuller, Angela Jacques, Louise H. Naylor, Daniel J. Green, Andrew Maiorana Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Combined heart –lung transplantation from a donation after circulatory death donor
We present the case of a critically ill 24-year-old man, who after waiting for>100 days in-hospital on the urgent transplant list, deteriorated further and underwent the first successful heart –lung transplant with organs from a donation after circulatory death. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 20, 2020 Category: Transplant Surgery Authors: Simon Messer, Yasir Abu-Omar, Stephen R. Large, Marius Berman, Aravinda Page, Pradeep Kaul, J.E. Arrowsmith, Richard Quigley, Caitlin Cheshire, Caroline Patterson, Debra Thomas, John Wallwork, Jasvir Parmar, Pedro Catarino Tags: INNOVATION Source Type: research

International experience using a durable, centrifugal-flow ventricular assist device for biventricular support
Heart transplantation is limited by the scarcity of suitable donors. Patients with advanced biventricular failure may require biventricular support to provide optimal cardiac output and end-organ perfusion. We highlight the outcomes of using the HeartWare HVAD System (HVAD) in a biventricular configuration. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 20, 2020 Category: Transplant Surgery Authors: Silvana Marasco, Andr é R. Simon, Steven Tsui, René Schramm, Sandra Eifert, Christian M. Hagl, Mustafa Paç, Ümit Kervan, Arnt E. Fiane, Florian M. Wagner, Jens Garbade, Mustafa Özbaran, Christopher S. Hayward, Daniel Zimpfer, Jan D. Schmitto Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

High Intensity Interval Training in Patients with Left Ventricular Assist Devices: a Pilot RCT
Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced chronic heart failure (CHF). To date, studies evaluating the impact of aerobic training in patients with LVADs have focused on moderate-intensity exercise. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 20, 2020 Category: Transplant Surgery Authors: Ignacio Moreno-Suarez, Anna Scheer, Kaitlyn Lam, Lawrence Dembo, Angela L. Spence, Christopher Hayward, David Kaye, Angela Leet, Louise M. Fuller, Angela Jacques, Louise H. Naylor, Daniel J. Green, Andrew Maiorana Tags: Original Clinical Science Source Type: research

INTERNATIONAL EXPERIENCE USING a durable, centrifugal flow ventricular assist device for BIVENTRICULAR SUPPORT
Heart transplant is limited by the scarcity of suitable donors. Patients with advanced biventricular failure may require biventricular support to provide optimal cardiac output and end organ perfusion. We highlight the outcomes of using the HeartWare ™ HVAD™ System in a biventricular configuration. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 20, 2020 Category: Transplant Surgery Authors: Silvana Marasco, Andr é R. Simon, Steven Tsui, René Schramm, Sandra Eifert, Christian M. Hagl, Mustafa Paç, Ümit Kervan, Arnt E. Fiane, Florian M. Wagner, Jens Garbade, Mustafa Özbaran, Christopher S. Hayward, Daniel Zimpfer, Jan D. Schmitto Source Type: research

Combined Heart-Lung Transplantation from a Donation after Circulatory Death (DCD) Donor
We present the case of a critically ill 24-year-old man, who after waiting over 100 days in-hospital on the urgent transplant list, deteriorated further and underwent the first successful heart-lung transplant with organs from a donation after circulatory death (DCD) donor. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 20, 2020 Category: Transplant Surgery Authors: Simon Messer, Yasir Abu-Omar, Stephen R. Large, Marius Berman, Aravinda Page, Pradeep Kaul, JE Arrowsmith, Richard Quigley, Caitlin Cheshire, Caroline Patterson, Debra Thomas, John Wallwork, Jasvir Parmar, Pedro Catarino Tags: Innovation Article Source Type: research

Secular Changes In Organ Donor Profiles and Impact On Heart And Lung Transplantation
Important innovations to clinical practice have resulted in an increase in the number of patients who can receive heart and lung transplants worldwide. Early in the course of transplantation, scientific advances focused on improving allograft survival which infused confidence for transplantation as a mainstream therapy. As the demand for donor organs grew steadily, attention shifted towards enhancements and practice changes designed to decrease discard rates for organs for transplantation. We outline principal factors in clinical decision making at the time of donor evaluation, many of which have transitioned from the expe...
Source: The Journal of Heart and Lung Transplantation - August 14, 2020 Category: Transplant Surgery Authors: Josef Stehlik, Mandeep R. Mehra Tags: EDITORIAL Source Type: research

Tumor necrosis factor- α inhibitor use for treatment of refractory cardiac sarcoidosis in a patient with left ventricular assist device: Adalimumab use in refractory sarcoidosis in a patient with left ventricular assist device
Sarcoidosis is an increasingly prevalent systemic disease resulting in granulomatous inflammation.1,2 Cardiac sarcoidosis (CS) can manifest as systolic heart failure (HF) resulting in increased morbidity and mortality. CS that progresses to end-stage HF may benefit from left ventricular assist device (LVAD) therapy to improve outcomes.3 The treatment of myocardial inflammation, as determined by 18-fludeoxyglucose positron emission tomography (FDG-PET), with immunosuppressive agents is central to prevent adverse cardiovascular events such as ventricular arrhythmias and even death. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 12, 2020 Category: Transplant Surgery Authors: Mrinalini Krishnan, Thomas R. Cupps, Farooq H. Sheikh Tags: CASE ANECDOTE, COMMENTS AND OPINIONS Source Type: research

Tumor Necrosis Factor-Alpha (TNF- α) Inhibitor Use for Treatment of Refractory Cardiac Sarcoidosis in an LVAD Patient
Classifications: (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 12, 2020 Category: Transplant Surgery Authors: Mrinalini Krishnan, Thomas R. Cupps, Farooq H. Sheikh Tags: Case Anecdotes, Comments and Opinions Source Type: research

An Acute Heart Failure Symptom Score For Children Hospitalized with Acute Decompensated Heart Failure
Currently there are no simple tools to evaluate acute heart failure (HF) symptom severity in children hospitalized with acute decompensated HF (ADHF).  We sought to develop an inpatient HF score that could be used as clinical tool and for clinical trials. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 8, 2020 Category: Transplant Surgery Authors: Christopher S. Almond, Sharon Chen, John C. Dykes, Joann Kwong, Danielle Burstein, David Rosenthal, Alaina Kipps, Jeffrey Teuteberg, Jenna Murray, Beth D. Kaufman, Seth A. Hollander, Elizabeth Profita, Vamsi Yarlagadda, Loren Sacks, Chiu-Yu Chen Tags: Original Clinical Science Source Type: research

Surveillance for Cardiac Allograft Vasculopathy: Practice Variations Among 50 Pediatric Heart Transplant Centers
Coronary allograft vasculopathy (CAV) is a leading cause of mortality after heart transplantation (HT) in children. Variation in CAV screening practices may impact detection rates and patient outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 8, 2020 Category: Transplant Surgery Authors: Deipanjan Nandi, Clifford Chin, Kurt R. Schumacher, Matthew Fenton, Rakesh K. Singh, Kimberly Y. Lin, Jennifer Conway, Ryan S. Cantor, Devin A. Koehl, Jacqueline M. Lamour, James K. Kirklin, Elfriede Pahl Tags: Original Clinical Science Source Type: research

Long-term outcome of orthotopic heart transplantation in Asians: An analysis of the United Network of Organ Sharing database
The demographics of patients undergoing orthotopic heart transplantation (OHT) in the United States (US) have changed over the past 10 years; an increasing number of racial and ethnic minorities such as Asians are undergoing OHT.1 Preliminary analysis of the outcomes in patients of Asian origin have reported favorable results; the 1-year survival has been reported as 90% with a median survival of 14 years for those patients surviving the first year.2,3 Moreover, in Asian countries with adequate annual surgical experience (e.g.,>12 cases/year in a majority of centers), even with small sample size, better survival rates h...
Source: The Journal of Heart and Lung Transplantation - August 5, 2020 Category: Transplant Surgery Authors: Shun Kohsaka, Yasuhiro Shudo, Hanjay Wang, Bharathi Lingala, Masataka Kawana, Y. Joseph Woo Tags: RESEARCH CORRESPONDENCE Source Type: research

Long-term outcome of orthotopic heart transplant in asians: an analysis of the united network of organ sharing database
The demographics of patients undergoing orthotopic heart transplantation (OHT) in the United States (US) have changed over the last 10 years; an increasing number of racial and ethnic minorities, such as Asians are undergoing OHT.1 Preliminary analysis of the outcomes in patients of Asian origin have reported favorable results; the 1-year survival has been reported as 90% with a median survival of 14 years for those patients surviving the first year.2,3 Moreover, in Asian countries with adequate annual surgical experience (e.g.,>12 cases/year in a majority of centers), even with small sample size, better survival rates ...
Source: The Journal of Heart and Lung Transplantation - August 5, 2020 Category: Transplant Surgery Authors: Shun Kohsaka, Yasuhiro Shudo, Hanjay Wang, Bharathi Lingala, Y. Masataka Kawana, Joseph Woo Source Type: research