Usefulness of Midodrine in Protein Losing Enteropathy
Protein losing enteropathy (PLE) is a highly morbid condition that is most commonly seen in Fontan failure (FF). While a subset of Fontan patients require heart transplant (HT) for systemic pump dysfunction, a number of patients require HT for refractory PLE in the setting of normal cardiac function.1 (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 15, 2019 Category: Transplant Surgery Authors: Angela J. Weingarten, Jonathan N. Menachem, Clayton A. Smith, Benjamin P. Frischhertz, Wendy M. Book Tags: Research Correspondence Source Type: research

Risk factors for death or heart transplantation in single-ventricle physiology (tricuspid atresia, pulmonary atresia, and heterotaxy): A systematic review and meta-analysis
In this study we sought to evaluate risk factors (RFs) for death or heart transplantation (D-HT) in single-ventricle (SV) physiology due to tricuspid atresia (TA), pulmonary atresia ‒intact ventricular septum (PA-IVS), and heterotaxy with SV (HX), clinical conditions for which outcome data are limited. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 4, 2019 Category: Transplant Surgery Authors: Aparna Kulkarni, Nishali Patel, Tajinder P. Singh, Elias Mossialos, Mandeep R. Mehra Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Risk Factors for Death or Heart Transplantation in Single Ventricle Physiology (Tricuspid Atresia, Pulmonary Atresia and Heterotaxy): A Systematic Review and Meta-analysis
We sought to evaluate risk factors (RF) for death or heart transplantation (D-HT) in single ventricle (SV) physiology due to tricuspid atresia (TA), pulmonary atresia-intact ventricular septum (PA-IVS) and heterotaxy-SV (HX), clinical conditions in which outcome data are limited. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 4, 2019 Category: Transplant Surgery Authors: Aparna Kulkarni, Nishali Patel, Tajinder P Singh, Elias Mossialos, Mandeep R Mehra Tags: Original Clinical Science Source Type: research

Usefulness of anti-platelet therapy testing in children supported with a ventricular assist device
Stroke is the most recognized complication associated with the Berlin Heart EXCOR pediatric ventricular assist device (VAD).1 –3 Thromboelastography with Platelet Mapping (TEG/PM) has become the most commonly used platelet function test utilized in U.S. children supported with the EXCOR4 after it was incorporated into the Edmonton Antithrombotic Guideline for the U.S. Food and Drug Administration Trial of the EXCOR (refe r to Supplementary Material available online at www.jhltonline.org/).1 Despite its use, stroke occurred in one third of children in the EXCOR trial. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Lindsay J. May, Xiaoxi Liu, Tiffany Tesoro, Jaden Yang, Clara Lo, Sharon Chen, Jenna Murray, David N. Rosenthal, Alan D. Michelson, Christopher S. Almond Tags: RESEARCH CORRESPONDENCE Source Type: research

Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment ―A consensus report from the Pulmonary Council of the ISHLT
The outcomes of transplantation vary widely by organ. Lung transplantation (LTx) has rather poor long-term outcome, with a current median post-transplant survival of 6.0years.1,2 Survival after organ transplantation is limited by both graft-related and non ‒graft-related factors. Allograft failure remains the leading cause of morbidity and mortality across all organ groups and is the major cause of death, accounting for>40% of deaths beyond the first year post-LTx.1,2 (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Geert M. Verleden, Allan R. Glanville, Erika D. Lease, Andrew J. Fisher, Fiorella Calabrese, Paul A. Corris, Christopher R. Ensor, Jens Gottlieb, Ramsey R. Hachem, Vibha Lama, Tereza Martinu, Desley A.H. Neil, Lianne G. Singer, Greg Snell, Robin Vos Tags: EDITORIAL Source Type: research

Stroke and death risk in ventricular assist device patients varies by ISHLT infection category: An INTERMACS analysis
Ventricular assist device (VAD) patients often experience infections, which increase the risk of stroke and mortality. Using the definitions of the International Society for Heart and Lung Transplantation (ISHLT), we have characterized differences in clinical outcomes for categories of infection: VAD-specific (e.g., pump component related); VAD-related (e.g., bloodstream infection, BSI); and non-VAD infections (e.g., pneumonia). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Palak Shah, Sarah E. Birk, Lauren B. Cooper, Mitchell A. Psotka, James K. Kirklin, Scott D. Barnett, Shalika B. Katugaha, Sheila Phillips, Mary M. Looby, Francis D. Pagani, Jennifer A. Cowger Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Chronic Lung Allograft Dysfunction: Definition and Update of Restrictive Allograft Syndrome (RAS) A Consensus Report from the Pulmonary Council of the ISHLT
The term “restrictive allograft syndrome” (RAS) was recently introduced to identify a specific phenotype of chronic lung allograft dysfunction (CLAD), that was characterized by restrictive pulmonary physiology and worse survival compared to the more common bronchiolitis obliterans syndrome (BOS). Since t he definition of RAS is not clear cut at present, the Pulmonary Council of the International Society for Heart and Lung Transplantation gathered a group of experts in the field with the primary aim to formulate a strict and useful definition of RAS. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Allan R Glanville, Geert M. Verleden, Jamie L. Todd, Christian Benden, Fiorella Calabrese, Jens Gottlieb, Ramsey R Hachem, Deborah Levine, Federica Meloni, Scott M. Palmer, Antonio Roman, Masaaki Sato, Lianne G Singer, Sofya Tokman, Stijn E Verleden, Jan Tags: Editorial Source Type: research

Chronic Lung Allograft Dysfunction: Definition, Diagnostic Criteria and Approaches to Treatment. A Consensus Report from the Pulmonary Council of the ISHLT
The term “chronic lung allograft dysfunction” (CLAD) has previously been introduced to identify patients with persistent pulmonary function decline after lung transplantation. Initially, CLAD was used as an umbrella term and encompassed all possible causes of pulmonary function decline, not only chronic rejection. Since chronic rejection has recently been phenotyped in bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and in a mixed phenotype, and because of different interpretations of the current CLAD definition, the Pulmonary Council of the International Society for H eart and Lun...
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Geert M. Verleden, Allan R. Glanville, Erika D. Lease, Andrew J Fisher, Fiorella Calabrese, Paul A. Corris, Christopher R. Ensor, Jens Gottlieb, Ramsey R. Hachem, Vibha Lama, Tereza Martinu, Desley A.H. Neil, Lianne G. Singer, Greg Snell, Robin Vos Source Type: research

Marijuana use and candidacy for heart transplantation
Marijuana use in potential candidates for heart transplantation is a highly controversial area with sparse evidence to guide decision-making. Although substance use disorder has long been considered a contraindication to organ transplantation, in the setting of changing state and local laws regarding the legality of marijuana, this issue has taken on new relevance for both patients and providers. Marijuana is the most commonly used illicit drug in the United States and is increasingly widespread among young adults. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Ersilia M. DeFilippis, Michael M. Givertz Tags: Perspective Source Type: research

Usefulness of antiplatelet therapy testing in children supported with a ventricular assist device
Stroke is the most recognized complication associated with the Berlin Heart EXCOR ® Pediatric ventricular assist device (VAD).1-3 Thromboelastography with Platelet Mapping® (TEG/PM) has become the most commonly used platelet function test in US children supported with the EXCOR®4 after it was incorporated into the Edmonton Antithrombotic Guideline for the FDA Trial of the EXCO R® (Supplementary File).1 Despite its use, stroke occurred in one-third of children in the EXCOR® trial.1-3 Thus, some clinicians have questioned its validity as a primary means to guide antiplatelet therapy dosing in EXCOR® r...
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Lindsay J. May, Xiaoxi Liu, Tiffany Tesoro, Jaden Yang, Clara Lo, Sharon Chen, Jenna Murray, David N. Rosenthal, Alan D. Michelson, Christopher S. Almond Tags: Research Correspondence Source Type: research

Left ventricular lusitropy and primary graft dysfunction in lung transplantation
Primary graft dysfunction (PGD) is a major cause of morbidity and mortality after lung transplantation. Its incidence has decreased with optimization of lung preservation strategies. It remains, however, an important problem, particularly in patients with pulmonary fibrosis and pulmonary hypertension.1 Its development is generally multifactorial and thus referred to as a syndrome. Biologically, activation of the innate immune system and increased endothelial permeability are the main drivers of pulmonary capillary leak after reperfusion. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 3, 2019 Category: Transplant Surgery Authors: Marc de Perrot, Karen McRae Tags: Editorial Source Type: research

Heart transplantation from donation-after-circulatory-death (DCD) donors: Back to the future ―Evolving trends in heart transplantation from DCD donors
Heart transplantation from donation-after-circulatory death (DCD) donors is not new. The first human heart transplant performed by Christiaan Barnard in 1967 was from a DCD donor, as were the heart transplants performed by other surgeons in the months that followed. After the establishment of brain-death criteria in 1968, virtually all donor hearts for the next 36years were recovered from donation-after-brain-death (DBD) donors. Between 2004 and 2007, surgeons in Denver, Colorado, performed 3 infant heart transplants from pediatric DCD donors. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 26, 2019 Category: Transplant Surgery Authors: Peter Macdonald, Kumud Dhital Tags: EDITORIAL Source Type: research

Heart Transplantation from Donation after Circulatory Death (DCD) Donors: back to the future Evolving trends in heart transplantation from DCD donors
Heart transplantation from DCD donors is not new. The first human heart transplant performed by Christiaan Barnard in 1967 was from a DCD donor as were the heart transplants performed by other surgeons in the months that followed. Following the establishment of brain death criteria in 1968, virtually all donor hearts for the next 36 years were recovered from DBD donors. Between 2004 and 2007 surgeons in Denver, Colorado performed 3 infant heart transplants from paediatric DCD donors.1 The protocol was designed to minimise the functional warm ischaemic time (FWIT) of the donor heart with co-location of donor and recipient i...
Source: The Journal of Heart and Lung Transplantation - March 26, 2019 Category: Transplant Surgery Authors: Peter Macdonald, Kumud Dhital Tags: Editorial Source Type: research

Frailty Trajectories in Adult Lung Transplantation: A Cohort Study
Frailty is common in adults with end-stage lung disease and is associated with death before and after lung transplantation. We aimed to determine whether frailty changes from before to after lung transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 18, 2019 Category: Transplant Surgery Authors: Aida Venado, Charles McCulloch, John Greenland, Patricia Katz, Allison Soong, Pavan Shrestha, Steven Hays, Jeffrey Golden, Rupal Shah, Lorriana E Leard, Mary Ellen Kleinhenz, Jasleen Kukreja, Lydia Zablotska, Isabel E Allen, Kenneth Covinsky, Paul Blanc, Source Type: research

Clinical Outcomes by Intended Goal of Therapy in the MOMENTUM 3 Clinical Trial: Final Analysis of the 1028 Patient Full Cohort
Candidates for Left Ventricular Assist Devices (LVAD) are often dichotomized by their primary intended goal of therapy into discrete categories such as bridge to transplantation (BTT) or destination therapy (DT). While questions about the clinical relevance of such arbitrary designations have been raised, it remains unclear whether differences in survival, clinical outcomes, and health-related quality of life exist in the modern era between patients labeled as BTT or DT, especially as a function of distinct pumps. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: D. Goldstein, M.R. Mehra, MOMENTUM 3 Investigators Tags: 1 Source Type: research

INSPIRE: A Phase 3 Open-Label, Multicenter Study to Evaluate the Safety and Tolerability of LIQ861 in Pulmonary Arterial Hypertension (PAH) (Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil NCT03399604)
Inhalational drug delivery to treat PAH is attractive due to enhanced pulmonary specificity and reduced systemic adverse effects. LIQ861 is a dry powder formulation of Treprostinil (TRE) designed to enhance deep-lung delivery and achieve higher tolerated dose levels than current inhaled therapies. LIQ861 ’s uniform (1µm) particle size with a trefoil, pollen-like shape, enables QID delivery of TRE doses in a convenient, palm-sized, disposable dry powder inhaler (DPI). The primary objective of the INSPIRE study is the safety and tolerability of LIQ861 in subjects transitioning from stable doses of Tyvaso® or ...
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: N.S. Hill, J.P. Feldman, S. Sahay, D.J. Levine, R.F. Roscigno, T.A. Vaughn, T.M. Bull Tags: 2 Source Type: research

Safety and Efficacy of Bacteriophage Therapy in Lung Transplant Candidates and Recipients
We describe BT in four lung transplant candidates and recipients with life-threatening MDR infections, including Pseudomonas aeruginosa (PsA) (n=3) and Burkholderia dolosa (n=1) (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A. Courtwright, C. Koval, S. Lehman, S. Morales, C.L. Furr, F. Rosas, M. Brownstein, J. Fackler, B.M. Sisson, B. Biswas, R.T. Schooley, S. Aslam Tags: 3 Source Type: research

Increased Volume, Improved Quality, and Better Outcomes Using a Specialized Thoracic Adapted Recovery (STAR) Model for Thoracic Transplantation: Experience from 1000 Cases
Recent changes in organ allocation policy address geographic disparities in access to donors in heart and lung transplant candidates. Consequently, new policies also increase logistic organ recovery challenges for transplant centers. Greater opportunity, efficiency, improved quality, and better outcomes may be realized with the adoption of a dedicated Specialized Thoracic Adapted Recovery (STAR) team model for heart and lung transplant programs. Previous studies highlight the benefits of regionalized abdominal donor organ recovery teams. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: H. Tetteh, P. Brandenhoff, R.S. Higgins Tags: 4 Source Type: research

Early Detection of Post-Transplant Lymphoproliferative Disorder Using Circulating Tumor DNA
Diffuse large B cell (DLBCL)-like post-transplant lymphoproliferative disorder (PTLD) affects up to 10% of thoracic transplant recipients. Although 50% of PTLDs can be related to Epstein-Barr virus (EBV) infection, and high or increasing EBV viral load may precede EBV+ PTLD, preemptive monitoring of EBV titers does not reliably predict PTLD . Consequently, we assessed the utility of circulating tumor DNA (ctDNA), a promising biomarker for many cancers including DLBCL, for early detection of PTLD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: J. Soo, J. Schroers-Martin, A. Garofalo, D. Kurtz, N. D'Emilio, H. Luikart, A. Alizadeh, K. Khush Tags: 5 Source Type: research

Distinct Heart Failure Phenotypes Identified by Myocardial Transcriptome Sequencing: Targets for Reverse Remodeling
Systolic heart failure (HF) is a progressive disease characterized by adverse remodeling from ischemia (ischemic cardiomyopathy, ICM) or a multitude of other causes termed non-ischemic cardiomyopathy (NICM). To accurately characterize the myocardial transcriptome in advanced HF using RNA-sequencing (RNAseq) and identify gene signatures that predict HF phenotypes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Shah, W. Zhu, S. Navankasattusas, D.K. Ramadurai, S.S. Desai, I. Taleb, I. Efimov, R. Singh, N. Aliyev, R.K. Iyer, O. Wever-Pinzon, S. McKellar, W.T. Caine, C.R. deFilippi, J. Zhu, S. Drakos Tags: 6 Source Type: research

A Novel Injury Site-Targeted Complement Inhibitor Which Protects against Lung Transplant Ischemia Reperfusion Injury
Self-reactive natural Abs initiate complement activation and injury following ischemia and reperfusion of certain tissues, but their role in post-ischemic lung injury is unknown. Here, we investigated the expression of two previously identified post-ischemic neoepitopes, namely a modified annexin IV epitope recognized by B4 IgM mAb, and an epitope consisting of a subset of phospholipids recognized by C2 IgM mAb, and additionally determined their role in lung transplant ischemia reperfusion injury (IRI). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: C. Li, K. Patel, P. Allen, Z. TU, J. Kilkenny, C. Wallace, S. Nadig, S. Tomlinson, C. Atkinson Tags: 7 Source Type: research

Engineered Mesenchymal Stromal Cell Therapy during Pig Ex Vivo Lung Perfusion and Transplant
Ex vivo lung perfusion (EVLP) enables novel therapeutic approaches to repair damaged lungs for transplantation. We investigated the concept and feasibility of elective cell therapy for donor lungs. Dosing, efficacy and transgene expression kinetics of engineered mesenchymal stromal cell therapy were examined in pig EVLP and transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A.I. Nykanen, A. Mariscal, M. Takahashi, A. Duong, A. Ali, M. Chen, A. Takahagi, H. Gokhale, C. Estrada, T. Martinu, S. Juvet, J. Yeung, T.K. Waddell, M. Cypel, M. Liu, J.E. Davies, S. Keshavjee Tags: 8 Source Type: research

Hydrogen-Rich Preservation Solution Attenuates Lung Ischemia-Reperfusion Injury after Prolonged Cold Ischemia in a Canine Left Lung Transplant Model
Molecular hydrogen (H2) has been reported as having protective effects on ischemia-reperfusion injury (IRI) in various organs. However, most of the reports are on inhalation of H2. Our group has previously reported the protective effects of H2-rich solution on lung IRI in a rat hilar-clamp model (Takahashi M, et al. Eur J Cardiothorac Surg 2017; 51: 442-448.) and the protective effects of hydrogen-rich preservation solution on lung preservation in a rat left lung transplant (LTx) model (Saito M, et al. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: H. Kayawake, T.F. Chen-Yoshikawa, M. Saito, S. Hirano, R. Kurokawa, H. Yamagishi, R. Okabe, F. Gochi, J. Tokuno, S. Ueda, Y. Yokoyama, M. Ikeda, H. Oda, Y. Yamada, Y. Yutaka, D. Nakajima, A. Ohsumi, M. Hamaji, H. Date Tags: 9 Source Type: research

Atorvastatin Preserves Cardiac Contractility via Reducing Matrix Metalloproteinase-2 Isoforms Expression in a Diabetic Heart Model
We investigated whether atorvastatin can alleviate diabetic cardiomyopathy (DM CMP) by reducing intracellular matrix metalloproteinase-2 (MMP-2) isoform expression. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: H. Lee, S. Lee, S. Song, S. Bae, S. Kim, J. Choi Tags: 10 Source Type: research

Triptolide Attenuates Graft Inflammation During Ex Vivo Lung Perfusion
Ex vivo lung perfusion (EVLP) has been proposed as a platform for lung graft assessment and preservation. However, its proinflammatory milieu may be associated with deterioration in graft quality which may contribute to posttransplant graft dysfunction. Triptolide (TL), a diterpenoid triepoxide, has recently been shown to have a therapeutic potential in various disease states due to its anti-inflammatory properties. Based on this, we sought to assess the impact of TL on graft preservation during EVLP as well as associated posttransplant outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Burki, K. Noda, B. Philips, P.G. Sanchez, A. Kumar, J. D'Cunha Tags: 11 Source Type: research

Diffusing Capacity for Carbon Monoxide (DLCO): A Predictor of CLAD and Death after Lung Transplantation in a 20-Year Longitudinal Study
The DLCO measures the capacity of the lungs to exchange gas across the alveolar-capillary interface. We hypothesized that DLCO is a sensitive measure of injurious allograft processes that can disrupt this interface. Our goals were to describe the trajectory of DLCO measurements after lung transplantation, and to determine the prognostic significance of DLCO on chronic lung allograft dysfunction (CLAD) and survival. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: D.R. Darley, J. Ma, E. Huszti, R. Ghany, M. Hutcheon, C. Chow, J. Tikkanen, S. Keshavjee, L.G. Singer, T. Martinu Tags: 12 Source Type: research

Molecular Analysis of Transbronchial and Mucosal Biopsies in Patients with CLAD
Chronic lung allograft dysfunction (CLAD) is a clinical/functional diagnosis that cannot be defined by histology in transbronchial biopsies (TBBs). Moreover, understanding the biology of CLAD is crucial for prevention and potential treatment. We studied gene expression associated with CLAD in TBBs, but also studied mucosal biopsies from the third bronchial bifurcation (3BMBs). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M. Parkes, P.F. Halloran, J. Chang, K.S. Famulski, J. Reeve, R. Hachem, P. Jaksch, S. Juvet, W. Klepetko, S. Keshavjee, D. Kreisel, A. Roux, G.I. Snell, E. Trulock, I.L. Timofte, G.P. Westall, K.M. Halloran Tags: 13 Source Type: research

Predictive Biomarkers for Bronchiolitis Obliterans
Chronic Allograft Dysfunction (CLAD) with Bronchiolitis obliterans (BOS) phenotype is a major limitation for long term survival after lung transplantation (LT). Predictive biomarkers for BOS are unavailable. Purpose of our study was to establish a tractable system to evaluate the effects of pre-transplant antibodies to self-antigens (AutoAbs) and to examine specific patterns that correlate with BOS. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: V. Kaza, C. Zhu, L. Feng, A. Reddy, C. Lacelle, L. Terada, M. Manish, S. Bollineni, A. Banga, F. Torres, J. Mullins, Q. Li Tags: 14 Source Type: research

Chest CT Has Prognostic Value at BOS Diagnosis after Lung Transplantation
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction, with bronchiolitis obliterans syndrome (BOS) as its most common phenotype. Bronchiectasis (BRECT), hyperinflation and airtrapping are considered the key features of BOS on chest CT. We investigated whether chest CT and key features have prognostic value at BOS diagnosis in patients with established BOS after LTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A. Van Herck, A. Sacreas, T. Heigl, J. Kaes, A. Vanstapel, S.E. Verleden, B.M. Vanaudenaerde, W. De Wever, G.M. Verleden, R. Vos Tags: 15 Source Type: research

Regulatory T Cells in Asymptomatic ISHLT Grade A1 Rejection and the Risk of Chronic Lung Allograft Dysfunction
We examined the ratio of regulatory T cells (Tregs, which express Foxp3) to T effector cells (Teff) in TBBx as a predictor of outcome. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M. White, L. Levy, S. Moshkelgosha, G. Zehong, S. Keshavjee, T. Martinu, S. Juvet Tags: 16 Source Type: research

Emergence of a Specific Intrapulmonary CD4+ T Cell Subset Prior to the Onset of Lung Allograft Dysfunction
We have applied cutting-edge mass cytometry (MC) technology to serial bronchoalveolar lavage (BAL) cells obtained from lung transplant recipients (LTRs) and have used it to compare the cellular composition of the BAL compartment in patients who remain stable or go on to develop lung allograft dysfunction (LAD), defined here as a drop, from any cause, in the forced expiratory volume in 1 second of 20% from the best post-transplant baseline value. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Moshkelgosha, L. Levy, T. Martinu, R. Zamel, C. Guidos, S. Keshavjee, J. Yeung, S.C. Juvet Tags: 17 Source Type: research

Increased Hazard of Chronic Lung Allograft Dysfunction in the Presence of Persistent and Complement Fixing Donor-Specific Antibodies
Long-term survival in lung transplant recipients (LTR) is limited in large part due to chronic lung allograft dysfunction (CLAD). Donor-specific antibodies (DSA) have been previously associated with more rapid high-grade rejection and mortality. Characteristics of these DSA may predict which antibodies are more harmful than others. The purpose of this investigation was to determine if C1q+ DSA is associated with increased CLAD in LTRs versus no DSA and C1q- DSA. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: C.J. Iasella, C.R. Ensor, M. Marrari, M. Mangiola, C.A. Moore, M.R. Morrell, J.M. Pilewski, J. D'Cunha, P. Sanchez, J.F. McDyer, A. Zeevi Tags: 18 Source Type: research

Right Ventricular Strain as a Predictor of Post-LVAD Early Right Ventricular Failure
Early right ventricular failure (RVF) occurs in up to 40% of patients following left ventricular assist device (LVAD) implantation and is associated with increased peri-operative mortality and prolonged hospitalization. We sought to determine the effectiveness of RV longitudinal strain (RVLS) in predicting post-LVAD RVF. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: L.W. Liang, E.Y. Birati, C. Justice, Y. Han Tags: 19 Source Type: research

Serial Assessment of Pulmonary Artery Pulsatility Index Provides Incremental Risk Assessment for Early Right Ventricular Failure after Left Ventricular Assist Device Implantation
PAPi (pulmonary artery pulsatility index) is a predictor of early right ventricular failure (RVF) post left ventricular assist device (LVAD) implantation and has been studied using hemodynamics from single, isolated time points. Since multiple clinical factors and therapies are known to impact RV function in pre-LVAD patients, we hypothesized that serial PAPi measurements would provide incremental risk stratification for early post-LVAD RVF. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M.H. Gonzalez, J. Wagener, A. Aggarwal, T. Buda, V. Menon, M. Jacob, W. Tang, E. Hsich, M. Tong, E. Soltesz, R. Starling, J. Estep, E. Joyce Tags: 20 Source Type: research

Bridging Biventricular Failure to Successful Heart Transplants: HVAD BiVAD versus TAH
LImited mechanical support options exist for patients in biventricular heart failure. Post-transplant outcomes in those bridged with BiVAD HVADs and Total Artificial Heart (TAH) have not been well described. We sought to examine post heart transplant outcomes of this cohort in a national registry. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A. Salimbangon, R. Chand, C. Lum, D. Vucicevic, E. DePasquale Tags: 21 Source Type: research

New Insights into Right Ventricular Function among Patients with Left Ventricular Assist Devices Using High Fidelity Conductance Catheters to Generate Real Time Pressure Volume Loops
Determine the impact of continuous-flow (CF) left ventricular devices (LVADs) on resting and exertional right ventricular (RV) performance. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: W.K. Cornwell, G. Coe, A. Levy, T. Tran, M. Bradley, K. O'Gean, M. Ostertag, M. Spotts, S. Laing, J. Lawley, C. DeSouza, B. Stauffer, A. Ambardekar, J. Pal, G. Wolfel, W. Kohrt Tags: 22 Source Type: research

Early and Late Right Heart Failure Following LVAD Implantation: Epidemiology, Natural History and Outcomes. An Analysis of the STS INTERMACS Database
Current data regarding early and late right heart failure (RHF) post-LVAD is confounded by small populations and variable definitions of RHF. In 2014, a new INTERMACS (IM) definition of RHF was introduced. Based on this contemporary definition, we sought to investigate the epidemiology and natural history of RHF after LVAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: C.J. Kapelios, L.H. Lund, C.H. Selzman, S.L. Meyers, A. Koliopoulou, J. Stehlik, O. Wever-Pinzon, A.G. Kfoury, J.C. Fang, J.K. Kirklin, S.G. Drakos Tags: 23 Source Type: research

Pectoralis Muscle Attenuation Improves the Prediction of Right Ventricular Failure after LVAD Implantation
Right ventricular failure (RVF) after LVAD implantation remains difficult to predict pre-operatively. As right heart failure is associated with muscle wasting, we hypothesized pectoralis muscle tissue attenuation quantified on pre-operative CT scans would enhance the prediction of RVF after LVAD implantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: H. Shah, T. Murray, J. Estep, R. Araujo, A. El Rafei, B. Trachtenberg, L. Teigen, J. Schultz, R. John, C. Martin, R. Cogswell Tags: 24 Source Type: research

Oral Milrinone for the Treatment of Right Ventricular Failure in LVAD Patients
Early and late right ventricular failure (RVF) are major complications during left ventricular assist device (LVAD) support. Therapies to treat RVF are limited, leading to significant morbidity and increased mortality. Intravenous inotropes are a therapy for severe, persistent cases of RVF, but long-term use carries significant risks of infection and thrombosis associated with venous access. CRD-102 is a novel, extended-release form of oral milrinone. The aim of this study is to evaluate the safety of CRD-102 in LVAD patients with chronic RVF. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: N. Uriel, D. Burkhoff, G. Kim, T. Silverstein, J. Raikhelkar, B. Smith, C. Juricek, V. Jeevanandam, R.M. Lang, G. Sayer Tags: 25 Source Type: research

Donor Utilization in the Australian National Paediatric Heart Transplant Program: Stretching the Limits
This study examines the impact of these strategies on outcomes, including survival. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: J. Wacker, A. Shipp, I. Konstantinov, J. Brink, R. Weintraub, J. Mathew Tags: 26 Source Type: research

Regional Variation in Donor Refusal Rates Correlates with Poor Wait List Outcomes
Geographic variation in donation rates, transplant rates, and post-transplant outcomes in solid organ transplantation is well-described. We sought to test the hypothesis that organ refusal rates vary across regions and are associated with worse survival. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: R.R. Davies, R. Butts, M. Bano, R.D. Jaquiss, R.C. Kirk Tags: 27 Source Type: research

Withdrawn
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Tags: 28 Source Type: research

Anti-Coagulation Management in Pediatric Ventricular Assist Device: A Quality Improvement Target
This report describes baseline AC data from ACTION centers, including agents used and aggregate levels of performance, to inform development of specific interventions. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: C. VanderPluym, M. O'Connor, A. Lorts, M. Ploutz, D. Peng, S. Law, M. Zinn, R. Niebler, D. Rosenthal, J. Conway, S. Auerbach, D. Sutcliffe, M. Mehegan Tags: 29 Source Type: research

Role of ECMO as Bridge to VAD Therapy in Critically Ill Pediatric Patients - An Analysis of the STS Pedimacs Database
Extra-corporeal membrane oxygenation (ECMO) as bridge to ventricular assist device (EB-VAD) therapy is frequently used for initial resuscitation of critically ill pediatric patients (INTERMACS 1& 2). Data regarding outcomes with this strategy is limited. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S.M. Peer, D.A. Koehl, R.S. Cantor, R.A. Jonas, P. Sinha Tags: 30 Source Type: research

Hospital Readmission Following Pediatric Heart Transplantation
The frequency, indications and outcomes for readmission following pediatric heart transplantation are poorly characterized. A better understanding of this phenomenon will help guide strategies to address the causes of readmission. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: W.T. Mahle, K. Mason, A. Dipchand, M. Richmond, C. Canter, D. Hsu, T.P. Singh, R. Shaddy, B. Armstrong, A. Zeevi, D. Ikle, H. Diop, J. Odim, S. Webber Tags: 31 Source Type: research

Slowed Progression of Maximal Intimal Thickening by Intravascular Ultrasound after Initiation of Sirolimus
Evidence in adult heart transplant (HT) patients (pt) shows that initiating sirolimus (SRL) slows progression of cardiac allograft vasculopathy (CAV) measured by intravascular ultrasound (IVUS). However, no data exist in children. We evaluated changes in maximal intimal thickness (MIT) using serial IVUS measurements in children who initiated SRL for increased MIT post-HT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: A. Putschoegl, L. Pyle, M. Everitt, S. Miyamoto, B. Pietra, S. Auerbach Tags: 32 Source Type: research

Sequential Measurement of Trypanosoma cruzi Parasitic Load in Endomyocardial Biopsies for Early Detection and Follow-up of Chagas Disease Reactivation After Heart Transplantation
To evaluate the parasitic load of the protozoan Trypanosoma cruzi (etiologic agent of Chagas disease) in sequential endomyocardial biopsies (EMB) of heart-transplanted, chagasic patients who presented reactivation of the disease affecting the allograft. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: L.A. Benvenuti, A. Rogg ério, A.S. Nishiya, S. Mangini, J.E. Levi Tags: 33 Source Type: research

The Paradigm of Gender: Mismatch and Its Influence on Short and Long-Term Outcomes after Heart Transplantation
It is known that gender mismatch constitutes a risk factor on early and late mortality in heart transplantation (HT). Its effect on the development of complications, such as primary graft dysfunction and cardiac allograft vasculopathy (CAV), has been less described. We aim to determine the impact of gender mismatch and its association with the development of complications such as cellular and/or antibody-mediated rejection (AMR), CAV and conditional survival in HT patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M.D. Gilbert, P.A. Morej ón, M.F. Renedo, E.F. Giordanino, L.E. Favaloro, R.D. Ratto, D.O. Absi, R.R. Favaloro, A.M. Bertolotti Tags: 34 Source Type: research

Incidence of Right Ventricular Dysfunction in Adult Patients Submitted to Heart Transplantation According to the Presence of Pre-Transplant Pulmonary Hypertension
Pre-transplant irreversible pulmonary hypertension (PH) is a contraindication to heart transplantation (HTx) due to the high risk of post-transplant right ventricular (RV) dysfunction. When ventricular assist devices (VAD) are not available, HTx may be considered in selected patients PH. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M.M. Lensi, A.S. Ramos, J. Xavier Junior, L.B. Seguro, S. Mangini, M.S. Ávila, I.W. Campos, A.P. Duque, F. Gaiotto, S.P. Steffen, F. Bacal, F.G. Marcondes-Braga Tags: 35 Source Type: research

The Effect of Donor-Recipient Heart Mass and Size Matching in Primary Graft Dysfunction Development after Heart Transplantation
To describe the characteristics of the donors accepted in our Center by means of donor/recipient (D/R) size, and to determine its relationship in the development of primary graft dysfunction (PGD). We analyzed the impact of PGD on 30 day mortality and survival (conditional) at 1 year. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M.D. Gilbert, P.A. Morej ón, M.F. Renedo, E.F. Giordanino, L.E. Favaloro, R.D. Ratto, D.O. Absi, R.R. Favaloro, A.M. Bertolotti Tags: 36 Source Type: research