The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Lung Donor Bronchoalveolar Lavage Positivity: Incidence, Risk Factors, and Lung Transplant Recipients ’ Outcome
Inconsistent data exists regarding the risk factors for bronchoalveolar lavage (BAL) positivity in lung donors, the incidence of donor-derived infections (DDI), and the effect of BAL positivity on lung transplant (LuTx) recipients ’ outcome. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 25, 2024 Category: Transplant Surgery Authors: Jacopo Fumagalli, Veronica Punzi, Vittorio Scaravilli, Serena Maria Passamonti, Letizia Corinna Morlacchi, Valeria Rossetti, Anna Maraschini, Caterina Matinato, Margherita Brivio, Ilaria Righi, Francesco Blasi, Alessandra Bandera, Lorenzo Rosso, Mauro Pan Tags: Original Clinical Science Source Type: research

Leukotriene B4: A Potential Mediator and Biomarker for Cardiac Allograft Vasculopathy
Cardiac allograft vasculopathy (CAV) remains the leading cause of long-term graft failure and mortality after heart transplantation. Effective preventive and treatment options are not available to-date, largely because underlying mechanisms remain poorly understood. We studied the potential role of leukotriene B4 (LTB4), an inflammatory lipid mediator, in development of CAV. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 23, 2024 Category: Transplant Surgery Authors: Dong Wang, Grigol Tediashvili, Daniel Kim, Xiaomeng Hu, Helen Luikart, Thomas Renne, Amy Tian, Kari C. Nadeau, Joachim Velden, Sonja Schrepfer, Kiran K. Khush Source Type: research

Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation
Long-term survival after lung transplantation (LTx) remains limited by Chronic Lung Allograft Dysfunction (CLAD), which includes two main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), with possible overlap. We aimed to detail and quantify pathological features of these CLAD sub-types. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Benjamin Renaud-Picard, Gregory Berra, David Hwang, Ella Huszti, Ei Miyamoto, Gerald J Berry, Prodipto Pal, Stephen Juvet, Shaf Keshavjee, Tereza Martinu Tags: Original Clinical Science Source Type: research

CD8+ T cell-mediated rejection of allogenic human induced pluripotent stem cell-derived cardiomyocyte sheets in human PBMC-transferred NOG MHC double knockout mice
Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) has emerged as a promising therapy to treat end-stage heart failure. However, immunogenicity of hiPS-CMs in transplanted patients has not been fully elucidated. Thus, in vivo models are required to estimate immune responses against hiPS-CMs in transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Ryu Matsumoto, Yin Enzhi, Kazuyoshi Takeda, Kodai Morimoto, Kyoko Yogo, Masaki Harada, Koji Tokushige, Yui Maehara, Saori Hirota, Yuko Kojima, Mamoru Ito, Nagako Sougawa, Shigeru Miyagawa, Yoshiki Sawa, Ko Okumura, Koichiro Uchida Tags: Original Translational Science Source Type: research

Determinants of physical quality of life in patients with chronic thromboembolic pulmonary hypertension after treatment: Insights from invasive exercise stress test
Impaired quality of life (QoL) is prevalent among patients with chronic thromboembolic pulmonary hypertension (CTEPH) despite improved survival due to medical advances. We clarified the physical QoL of patients with CTEPH with mildly elevated pulmonary hemodynamics and evaluated its determinants using a database of patients with CTEPH evaluated for hemodynamics during exercise. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 16, 2024 Category: Transplant Surgery Authors: Kosuke Watabe, Ayumi Goda, Kazuki Tobita, Sachi Yokoyama, Hanako Kikuchi, Kaori Takeuchi, Takumi Inami, Kyoko Soejima, Takashi Kohno Source Type: research

ABO-incompatible Heart Transplantation - evolution of a revolution
In the 1990s, neonates born with severe congenital heart disease faced more than 50% mortality awaiting an ABO-compatible (ABOc) transplant donor. This desperate situation, together with knowledge on gaps of the adaptive immune system in early childhood, led to the clinical exploration of intentional ABO-incompatible (ABOi) heart transplantation. In 2001, West et al. reported the first series of 10 infants in Canada. Since then, consideration of ABOi heart donors has become standard of care for children awaiting transplantation in the first few years of life, resulting in reduced wait times and better organ utilization wit...
Source: The Journal of Heart and Lung Transplantation - April 8, 2024 Category: Transplant Surgery Authors: Neha Bansal, Lori J. West, Jacob Simmonds, Simon Urschel Tags: State of the art Source Type: research

A Prospective Randomized Controlled Trial of Direct Oral Anticoagulant Therapy with a Fully Magnetically Levitated LVAD: The DOT-HM3 Study
Purpose: Although the fully magnetically levitated HeartMate 3 (HM3) LVAD has demonstrated superiority in reducing pump thrombosis and stroke outcomes, the residual risk for non-surgical bleeding remains high. Whether direct oral anticoagulants that inhibit Factor Xa when used instead of Vitamin-K Antagonists (VKA) with the HM3 pump are safe, preserve clinical outcomes, and favorably influence bleeding complications remains unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , Z. Tucanova, P. Ivak, S. Gregor, D.M. Kolesar, T. Marek, V. Melenovsky, J. Binova, Z. Dorazilova, M. Hegarova, M. Podolec, H. Riha, J. Connors, M.R. Mehra Source Type: research

The Assist CLAD Study - Mesenchymal Stromal Cell Therapy in Chronic Lung Allograft Dysfunction
Purpose: Mesenchymal stromal cells (MSC) are immunosuppressive and immunoregulatory. Following phase 1 confirmation of feasibility and safety, the ASSIST CLAD study was a multi-centre, phase 2, double-blind, randomised controlled clinical trial of intravenous (IV) allogenic bone-marrow derived MSC in lung transplant recipients with new onset chronic lung allograft dysfunction (CLAD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , G. Westall, D. Darley, A. Glanville, M. Malouf, M. Musk, M. Sturm, C. Holmes-Liew, S. Lawrence, D. Bushell, L. Holsworth, N. Lawson, L. Singleton, S. Timmins, D. Enever, H. Wildermuth, O. Daka, B. Cooper, S.H. Apte, A. Pham, S. Haines, L. Zhang, M. Tan, Source Type: research

Non-Ischemic Preservation of the Donor Heart in Heart Transplantation - A Randomized, Controlled, Multicenter Trial Using The Xvivo Heart Assist Preservation System for Hypothermic Oxygenated Perfusion (NIHP2019)
Purpose: Cold static storage remains the worldwide gold standard for preserving donor hearts prior to transplantation. We evaluated if continuous, hypothermic, oxygenated perfusion of the donor heart with the XVIVO heart preservation technology, so called non-ischemic heart preservation (NIHP), is safe and superior compared to ischemic cold static storage. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , G. Lebreton, M. Para, S. Michel, R. Schramm, E. Begot, K. Vandendriessche, C. Kamla, G. Gerosa, M. Berman, U. Boeken, S. Clark, A. Ranasinghe, F. Ius, A. Forteza, F. Hennig, S. Gunter, A. Zuckermann, C. Knosalla, G. Dellgren, A. Wallinder Source Type: research

Early Outcomes and Trends in Use of Donation After Circulatory Death (DCD) Donors for Multi-Organ Heart Transplantation (HT) in US
Purpose: DCD-donors have become an important source of organs for HT, but there is limited data regarding their use for multi-organ HT. We evaluated the trend and early outcomes of DCD-donor use in multi-organ HT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S.R. Patel, C. Diez-Lopez, J.A. Ovalle Ramos, O. Saeed, Y. Rochlani, S. Vukelic, S. Murthy, J. Shin, D. Sims, S. Forest, J. Borgi, D.J. Goldstein, U.P. Jorde, S. Madan Source Type: research

Cardiac Donation After Circulatory Death in Adult Congenital Heart Disease: Early Experiences and Outcomes
Purpose: Cardiac donation after circulatory death (DCD) has increased with results comparable to donation after brain death (DBD) in adults. However, its use in adult congenital heart disease (ACHD) is not well studied. We aimed to characterize outcomes of cardiac DCD in ACHD population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Weber, J. Beller, L. Yarboro Source Type: research

Real-World Clinical Outcomes of DCD Heart Transplantation from the OCS Heart Perfusion (OHP) Registry: Benchmarking to Other Preservation Methods
This report evaluates characteristics and clinical outcomes of DCD heart transplants using OCS Heart System to concurrent DCD heart transplants using other methods of reperfusion/preservation at the same US institutions. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C. Milano, , M. Daneshmand, D. D'Alessandro, S. Pham, G. Couper, A. Shah, J. Pal, L. Klein, F. Esmailian, R. Davis, M. Villavicencio, A. Shaffer, B. Sun, K. Takeda, D. Pham, R. Malyala, H. Mallidi, J. Haft, D. Meyer, L. Durham, D. Goldstein, M. Funamoto, Source Type: research

Impact of Institutional Volume on Outcomes Following DCD Heart Transplantation in the United States
Purpose: Since the reintroduction of heart donation following circulatory death (DCD) in the United States in 2019, there has been an increasing uptake with variable center experience. In this analysis we examine national DCD outcomes and examine the impact of center volume on survival. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D.Y. Tam, Q. Chen, D. Emerson, M. Bowdish, J. Chikwe, D. Megna, P. Catarino Source Type: research

CRISPR-Cas Genome Editing in Ex Vivo Human Lungs
In this study, we developed CRISPR-Cas genome editing to induce IL-10 and evaluated it in ex vivo human donor lungs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Yamamoto, S. Juvet, J. Yeung, Z. Guan, Y. Yao, M. Chen, H. Gokhale, H. Shan, A. Wang, G. Wilson, A. Mariscal, J. Hu, A. Davidson, B. Kleinstiver, M. Cypel, M. Liu, S. Keshavjee Source Type: research

High-Dimensional Lung Tissue Imaging Reveals Temporal Changes in Immune Cell Populations and Cell Interactions During Progression of Chronic Lung Allograft Dysfunction (CLAD)
Purpose: The immunological drivers of progressive CLAD at a tissue level are poorly understood. Tissue imaging using mass spectrometry (IMC) and laser ablation of regions of interest (ROI) offers single-cell resolution of distinct immune cell populations and their spatial relationships in disease and may improve our understanding of CLAD pathophysiology. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Hunter, D. McDonald, G. Merces, G. Sheldon, P. Pradere, J. Majo, J. Pulle, A. Vanstapel, B. Vanaudenaerde, R. Vos, A.J. Filby, A.J. Fisher Source Type: research