Sizing it Up in Heart Transplantation: Time to Change the Guidelines?
It's not the size of a man, but the size of his heart that matters.Evander Holyfield, American professional boxer (1962-) (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 14, 2018 Category: Transplant Surgery Authors: Michael M. Givertz Tags: Editorial Source Type: research

Utilization of organs to pediatric heart transplant recipients
While survival after pediatric heart transplantation (pHT) has improved in the past few decades and mechanical circulatory support is increasingly used to bridge children to transplantation, waiting list deaths remain a stark reality. To increase the donor pool, strategies such as ABO-incompatible transplantation or donation after cardiac death (DCD) have been attempted.1,2 The real question we have to ask is whether the current donor pool offers are appropriately being used. The article by Davies and colleagues in this issue of the journal looked at the rate of declines in donor offers for pediatric recipients and their c...
Source: The Journal of Heart and Lung Transplantation - December 14, 2018 Category: Transplant Surgery Authors: Martin Schweiger, Franz F. Immer Tags: Editorial Source Type: research

Azithromycin and early allograft function after lung transplantation: a randomized controlled trial
Chronic lung allograft dysfunction (CLAD) is the single most important factor limiting long-term survival after lung transplantation (LTx). Azithromycin has been shown to improve CLAD-free and long-term survival, yet the possible impact on early lung allograft function is unclear. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 14, 2018 Category: Transplant Surgery Authors: Anke Van Herck, Anna E. Frick, Veronique Schaevers, Dr. Annelies Vranckx, Eric K. Verbeken, Bart M. Vanaudenaerde, Annelore Sacreas, Tobias Heigl, Arne P. Neyrinck, Dirk Van Raemdonck, Lieven J. Dupont, Jonas Yserbyt, Stijn E. Verleden, Geert M. Verleden, Tags: Original Clinical Science Source Type: research

End of Life for Patients with Left Ventricular Assist Devices: Insights from INTERMACS
Trial and registry data have reported mortality rates and causes of death in patients with left ventricular assist devices (LVADs); however, a more granular description is needed of end of life including location of death and quality of life (QOL) to better guide expectations and care. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 14, 2018 Category: Transplant Surgery Authors: Colleen K. McIlvennan, Kathleen L. Grady, Daniel D. Matlock, Laura J. Helmkamp, Martha Abshire, Larry A. Allen Tags: Original Clinical Science Source Type: research

Capillary Density in Right Ventricular Myocardium in Congenital Heart Disease
Right ventricular failure (RVF) is still associated with an increased mortality in patients with pulmonary hypertension (PH) or congenital heart disease. Transition from right ventricular dysfunction to RVF is not predictable and has not been well understood so far. Several studies in rodents and in piglets showed that impairment of capillary density (CD) in the right ventricle (RV) is associated with right ventricular failure (1, 2). Some evidence suggested that the RV of patients with Eisenmenger Syndrome (ES) has remarkable adaptive capacities to high pulmonary pressures (3), leading to a longer survival in these patien...
Source: The Journal of Heart and Lung Transplantation - December 7, 2018 Category: Transplant Surgery Authors: Pierre-Emmanuel Noly, Peter Dorfm üller, Elie Fadel, Olaf Mercier Tags: Research Correspondence Source Type: research

Montelukast in chronic lung allograft dysfunction after lung transplantation
Chronic lung allograft dysfunction (CLAD) is a major cause of post-lung transplant mortality with limited medical treatment options. We assessed the association of montelukast treatment with pulmonary function and outcome in lung transplant recipients with progressive CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 7, 2018 Category: Transplant Surgery Authors: Robin Vos, Ruben Vanden Eynde, David Ruttens, Stijn E. Verleden, Bart M. Vanaudenaerde, Lieven J. Dupont, Jonas Yserbyt, Eric K. Verbeken, Arne P. Neyrinck, Dirk E. Van Raemdonck, Geert M. Verleden, The Leuven Lung Transplant Group Source Type: research

The added value of cardiopulmonary exercise testing in the follow-up of pulmonary arterial hypertension
The added value of cardiopulmonary exercise testing (CPET) in the follow-up of patients with stable pulmonary arterial hypertension (PAH) remains undefined. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 7, 2018 Category: Transplant Surgery Authors: Roberto Badagliacca, Silvia Papa, Roberto Poscia, Gabriele Valli, Beatrice Pezzuto, Giovanna Manzi, Roberto Torre, Daniele Gianfrilli, Susanna Sciomer, Paolo Palange, Robert Naeije, Francesco Fedele, Carmine Dario Vizza Tags: Original Clinical Science Source Type: research

Inter-rater agreement in the diagnosis of chronic lung allograft dysfunction following lung transplantation
Chronic lung allograft dysfunction (CLAD) affects over 50% of lung transplant recipients (LTR) by five years and remains the primary reason for graft failure 1. It has been increasingly recognized that CLAD is a heterogeneous diagnosis with variable prognosis and different phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Precise diagnosis of CLAD remains difficult: There are no clinically-validated biomarkers, and diagnosis can be subjective, hinging on the correct interpretation of pulmonary function tests (PFTs) coupled with exclusion of clinical confounders. (Source: The Jour...
Source: The Journal of Heart and Lung Transplantation - December 7, 2018 Category: Transplant Surgery Authors: Cynthia E. Fisher, Siddhartha G. Kapnadak, Erika D. Lease, Jeffrey D. Edelman, Ajit P. Limaye Tags: RESEARCH CORRESPONDENCE Source Type: research

Hypothermic Perfusion of Donor Heart With a Preservation Solution Supplemented by Mesenchymal Stem Cells
Heart transplantation is the definitive treatment for end-stage heart failure. A shortage of donor hearts forced transplant programs to accept older donors and longer ischemic times. Previous studies have suggested that the administration of mesenchymal stem cells (MSCs) or their conditioned medium (CM) protects the heart against ischemia/reperfusion injury (IRI). We hypothesized that the preservation of donor hearts with a CM would protect the graft from IRI after prolonged storage in 15-month-old rats and investigated mRNA-changes attributable to CM. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - December 7, 2018 Category: Transplant Surgery Authors: Sevil Korkmaz-Ic öz, Shiliang Li, Regina Hüttner, Mihály Ruppert, Tamás Radovits, Sivakkanan Loganathan, Alex Ali Sayour, Paige Brlecic, Felix Lasitschka, Matthias Karck, Gábor Szabó Tags: Original Pre-Clinical Science Source Type: research

Diffusion capacity of the lung – a disease biomarker linking ventilation and circulation
Risk stratification of pulmonary arterial hypertension (PAH) is in the center of health care interests and has recently been addressed by numerous studies that are based on large international PH registries (1-5). Less evidence exists for Group 3 PH (6). Therefore, Rose et al, in their paper in this issue of JHLT, are to be commended on their efforts to identify predictors of survival in Group 3 PH patients, to characterize the clinical phenotypes and survival differences between patients with mild and severe Group 3 PH, and to evaluate how the etiology of lung disease impacts patient profiles and survival. (Source: The Jo...
Source: The Journal of Heart and Lung Transplantation - December 1, 2018 Category: Transplant Surgery Authors: Inbal Shafran, Irene M Lang Tags: Editorial Source Type: research

On broader geographic sharing of donor lungs
In this issue of the Journal, Dr. Mooney and colleagues report their analysis of the impact of lung allocation across broader geographic areas, rather than allocation first within a donor service area (DSA), or organ procurement organizations (OPOs)1. To better appreciate the importance of this study, some historical context might be helpful. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 30, 2018 Category: Transplant Surgery Authors: Thomas M. Egan Source Type: research

Use of An Implantable Wireless Pulmonary Pressure Monitor during Transition of Therapy in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a chronic and rapidly progressive disease, characterized by remodeling and vasoconstriction of the pulmonary vasculature, leading to increased pulmonary vascular resistance. PAH continues to be life-threatening, with high mortality despite advances in therapy. Current guidelines support the use of combination therapies that target the endothelin, nitric-oxide, and prostacyclin pathways. However, prostacyclin therapy has long been considered the gold standard for high risk patients, and intravenous (IV) prostacyclin therapy is the only medication shown to improve survival in PAH. (So...
Source: The Journal of Heart and Lung Transplantation - November 24, 2018 Category: Transplant Surgery Authors: Sophia Airhart, Nathan Verlinden, Nima Badie, Amresh Raina, Raymond Benza Tags: Research Correspondence Source Type: research

Perils of bridge to transplantation in patients on continuous-flow left ventricular assist devices
Although overall heart transplantation outcomes and survival have clearly improved over the last several decades, the concomitant outcomes with primary graft dysfunction (PGD) have been less defined. The ISHLT Consensus Conference laid down the framework toward a common definition of PGD and highlighted the historical and contemporary variability in reported incidence across institutions.1 In the current era of increasing numbers of patients on left ventricular assist device (LVAD) support, it seems that some centers have experienced an increase in the incidence and severity of PGD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 22, 2018 Category: Transplant Surgery Authors: Nader Moazami, Alex Reyentovich Tags: EDITORIAL Source Type: research

The Perils of Bridge to Transplantation in Patients on Continuous Flow LVADs
While overall heart transplantation outcomes and survival have clearly improved over the last several decades, the concomitant outcomes with primary graft dysfunction (PGD) have been less defined. The ISHLT Consensus Conference laid down the framework towards a common definition of PGD and highlighted the historical and contemporary variability in reported incidence across institutions.1 In the current era of increasing number of patients on LVAD support, it seems that various centers have experienced an increase in the incidence and severity of primary graft dysfunction PGD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 22, 2018 Category: Transplant Surgery Authors: Nader Moazami, Alex Reyentovich Tags: Editorial Source Type: research

Initial combination therapy with ambrisentan  + tadalafil on pulmonary arterial hypertension‒related hospitalization in the AMBITION trial
In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) vs pooled monotherapy. These results were primarily driven by a reduction in PAH-related hospitalization in the combination therapy group, although a significant effect was not observed in a post-hoc analysis of all-cause hospitalization. (Source: The Journal of Heart a...
Source: The Journal of Heart and Lung Transplantation - November 21, 2018 Category: Transplant Surgery Authors: Jean-Luc Vachi éry, Nazzareno Galiè, Joan Albert Barberá, Adaani E. Frost, Hossein-Ardeschir Ghofrani, Marius M. Hoeper, Vallerie V. McLaughlin, Andrew J. Peacock, Gérald Simonneau, Christiana Blair, Karen L. Miller, Jonathan Langley, Lewis J. Rubin, Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Initial combination therapy with ambrisentan+tadalafil on pulmonary arterial hypertension-related hospitalization in the ambition trial
In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) versus pooled monotherapy. These results were primarily driven by a reduction in PAH-related hospitalization in the combination therapy group, though a significant effect was not observed in a post-hoc analysis of all-cause hospitalization. (Source: The Journal of Heart...
Source: The Journal of Heart and Lung Transplantation - November 21, 2018 Category: Transplant Surgery Authors: Jean-Luc Vachi éry, Nazzareno Galiè, Joan Albert Barberá, Adaani E Frost, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Vallerie V McLaughlin, Andrew J Peacock, Gérald Simonneau, Christiana Blair, Karen L. Miller, Jonathan Langley, Lewis J Rubin, for t Tags: Original Clinical Science Source Type: research

Cell Replacement in Human Lung Bioengineering
As the number of patients with end-stage lung disease continues to rise, there is a growing need to increase the limited number of lungs available for transplantation. Unfortunately, attempts at engineering functional lung de novo have been unsuccessful, and artificial mechanical devices have limited utility as a bridge to transplant. This difficulty is largely due to the size and inherent complexity of the lung; however, recent advances in cell-based therapeutics offer a unique opportunity to enhance traditional tissue engineering approaches with targeted site- and cell-specific strategies. (Source: The Journal of Heart a...
Source: The Journal of Heart and Lung Transplantation - November 21, 2018 Category: Transplant Surgery Authors: Brandon A. Guenthart, John D. O'Neill, Jinho Kim, Kenmond Fung, Gordana Vunjak-Novakovic, Matthew Bacchetta Tags: Original Pre-Clinical Science Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Source Type: research

Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device
In this study we investigated the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Alberto Pinsino, Francesco Castagna, Amelia M. Zuver, Eugene A. Royzman, Mojdeh Nasiri, Eric J. St öhr, Barbara Cagliostro, Barry McDonnell, John R. Cockcroft, A. Reshad Garan, Veli K. Topkara, P. Christian Schulze, Koji Takeda, Hiroo Takayama, Yoshifumi Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Freedom from chronic lung allograft dysfunction (CLAD) or CLAD-free survival: What's in a name?
Long-term outcomes after lung transplantation (LTx) remain inferior to those of other solid organs, such as heart transplantation. This is largely the result of a high prevalence of chronic lung allograft dysfunction (CLAD), which affects approximately 50% of transplanted patients at 5 years post-transplant.1 Although bronchiolitis obliterans syndrome (BOS) is the major clinical phenotype of CLAD (occurring in 70% of CLAD patients), restrictive allograft syndrome (RAS), the other CLAD phenotype (30%), has shown worse survival after diagnosis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Geert M. Verleden, Stijn E. Verleden, Robin Vos Tags: EDITORIAL Source Type: research

Outcomes from a recovery protocol for patients with continuous-flow left ventricular assist devices
This retrospective analysis evaluates a standardized echocardiographic assessment and an invasive technique for patient selection for successful continuous flow left ventricular assist device (cf-LVAD) explantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Jan H. Knierim, Roland Heck, Marina Pieri, Felix Schoenrath, Sajjad Soltani, P Stawowy, Stephan Dreysse, Julia Stein, Marcus M üller, Johanna Mulzer, Michael Dandel, Volkmar Falk, Thomas Krabatsch, E Evgenij Potapov Tags: Original Clinical Science Source Type: research

Development of a transplant injection device for optimal distribution and retention of human iPSC-derived cardiomyocytes
The objective of the present study was to develop a method to improve the retention of hiPSCs in the myocardium for cardiac therapy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Ryota Tabei, Shinji Kawaguchi, Hideaki Kanazawa, Shugo Tohyama, Akinori Hirano, Noriko Handa, Shuji Hishikawa, Takumi Teratani, Satoshi Kunita, Junichi Fukuda, Yoshihiro Mugishima, Tsuneyoshi Suzuki, Kazuaki Nakajima, Tomohisa Seki, Yoshikazu Kishino, Mar Tags: Original Pre-Clinical Science Source Type: research

Prognostic implications of serial outpatient blood pressure measurements in patients with a left ventricular assist device
Elevated blood pressure (BP) has been linked to adverse events during left ventricular assist device support. We aimed to investigate the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Alberto Pinsino, Francesco Castagna, Amelia M Zuver, Eugene A Royzman, Mojdeh Nasiri, Eric J St öhr, Barbara Cagliostro, Barry McDonnell, John R Cockcroft, A Reshad Garan, Veli K Topkara, P Christian Schulze, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Tags: Original Clinical Science Source Type: research

Impact of Disease Process on Post-Transplant Outcomes: Protein Losing Enteropathy in Fontan Patients
Since the Fontan operation was first performed in 1968, the procedure has been refined to afford the best long-term outcome for patients with single ventricle physiology, with recent studies showing 70% freedom from Fontan failure including the need for cardiac transplant at 20 years.1 Despite these improvements, the inherent physiology of the Fontan palliation with passive venous blood flow from the body to the pulmonary arteries can result in a variety of complications related to chronic venous congestion and low cardiac output. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Jennifer Conway, Hari Tunuguntla Tags: Editorial Source Type: research

Freedom from CLAD or CLAD-free survival: what's in a name?
Long-term outcomes after lung transplantation (LTx) remain inferior to other solid organs such as heart transplantation. This is largely a result of a high prevalence of chronic lung allograft dysfunction (CLAD), affecting approximately 50% of transplanted patients at 5 years post-transplant.1 Although Bronchiolitis Obliterans Syndrome (BOS) is the major clinical phenotype of CLAD (occurring in 70% of CLAD patients), Restrictive Allograft Syndrome (RAS), the other CLAD phenotype (30%), has a worse survival following diagnosis. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 15, 2018 Category: Transplant Surgery Authors: Geert M. Verleden, Stijn E. Verleden, Robin Vos Tags: Editorial Source Type: research

Prognostic significance of early pulmonary function changes after the onset of chronic lung allograft dysfunction
Chronic lung allograft dysfunction (CLAD) is the principal obstacle to improved long-term survival after lung transplantation.1 CLAD is a condition of sustained lung function impairment recognized by a persistent decline in the forced expiratory volume in one second (FEV1) relative to the highest posttransplant baseline after exclusion of confounding conditions.2,3 Previously bronchiolitis obliterans syndrome (BOS) was the most widely described CLAD phenotype; however, accumulating evidence suggests CLAD takes on at least two phenotypes conferring distinct prognoses. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 1, 2018 Category: Transplant Surgery Authors: Jamie L. Todd, Megan L. Neely, C. Ashley Finlen Copeland, Courtney W. Frankel, John M. Reynolds, Scott M. Palmer Tags: Original Clinical Science Source Type: research

Outcomes of children with congenital heart disease implanted with ventricular assist devices: An analysis of the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs)
Reported ventricular assist device (VAD) experience in the pediatric congenital heart disease (CHD) population is limited. We sought to describe contemporary use and outcomes of VADs in children with CHD and compare outcomes to children without CHD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 1, 2018 Category: Transplant Surgery Authors: David M Peng, Devin A Koehl, Ryan S Cantor, Kristen N McMillan, Aliessa P Barnes, Patrick I McConnell, Jessica Jordan, Nicholas D Andersen, James D. St. Louis, Katsuhide Maeda, James K Kirklin, Steven J Kindel Tags: Original Clinical Science Source Type: research

Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model
Continuous-flow ventricular assist devices (CF-VADs) produce non-physiologic flow with diminished pulsatility, which is a major risk factor for development of adverse events, including gastrointestinal (GI) bleeding and arteriovenous malformations (AVMs). Introduction of artificial pulsatility by modulating CF-VAD flow has been suggested as a potential solution. However, the levels of pulsatility and frequency of CF-VAD modulation necessary to prevent adverse events are currently unknown and need to be evaluated. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - November 1, 2018 Category: Transplant Surgery Authors: Thomas A. Haglund, Namakkal S. Rajasekaran, Benjamin Smood, Guruprasad A. Giridharan, Charles W. Hoopes, William L. Holman, David C. Mauchley, Sumanth D. Prabhu, Salpy V. Pamboukian, Jose A. Tallaj, Indranee N. Rajapreyar, James K. Kirklin, Palaniappan Se Tags: ORIGINAL PRE-CLINICAL SCIENCE Source Type: research

Evaluation of Flow Modulation Approaches In Ventricular Assist Devices (VADs) Using an In-Vitro Endothelial Cell Culture Model (ECCM)
Ventricular assist devices (VADs) are currently standard therapy for patients with advanced heart failure that is refractory to medical therapy.1 VADs can be categorized as pulsatile flow VADs (PF-VADs) and continuous flow VADs (CF-VADs). Both PF-VADs and CF-VADs are similarly effective in providing hemodynamic benefit (augmenting cardiac output and end-organ perfusion, and reducing ventricular work), and improving the quality of life and functional capacity of patients.2,3 CF-VADs are preferred over the PF-VADs due to advantages including compact size, reliability, energy efficiency, ease of implantation, and operation. (...
Source: The Journal of Heart and Lung Transplantation - November 1, 2018 Category: Transplant Surgery Authors: Thomas A. Haglund, Namakkal S. Rajasekaran, Benjamin Smood, Guruprasad A. Giridharan, Charles W. Hoopes, William L. Holman, David C. Mauchley, Sumanth D. Prabhu, Salpy V. Pamboukian, Jose A. Tallaj, Indranee N. Rajapreyar, James K. Kirklin, Palaniappan Se Tags: Original Pre-Clinical Science Source Type: research

Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction
We examined changes in forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) over the first 18 months after CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 31, 2018 Category: Transplant Surgery Authors: Jamie L. Todd, Megan L. Neely, C.A. Finlen Copeland, Courtney W. Frankel, John M. Reynolds, Scott M. Palmer Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Outcomes of children supported with an intracorporeal continuous-flow left ventricular assist system
Since 2012, there has been growing use of the HeartWare (Medtronic, Mounds View, MN) intracorporeal continuous flow (CF) ventricular assist device (VAD) in children, despite it not being labeled for use in pediatric patients. We sought to describe the use and outcomes of children with HeartWare VADs. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 31, 2018 Category: Transplant Surgery Authors: Christina J. VanderPluym, Iki Adachi, Robert Niebler, Eric Griffiths, Francis Fynn-Thompson, Sharon Chen, Matthew J. O'Connor, Desiree Machado, Beth Hawkins, Mark S. Bleiweis, Devin A. Koehl, Ryan S. Cantor, David Morales, Angela Lorts Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 26, 2018 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 26, 2018 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 26, 2018 Category: Transplant Surgery Source Type: research

Long-term outcomes after transplantation after support with a pulsatile pediatric ventricular assist device
There has been increasing use of durable ventricular assist devices (VAD) in children as a bridge to transplantation (BTT). The Berlin Heart investigational device exemption (IDE) trial was the first pediatric VAD trial to demonstrate excellent survival outcomes as a BTT. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 26, 2018 Category: Transplant Surgery Authors: Aamir Jeewa, Michiaki Imamura, Charles Canter, Robert A. Niebler, Christina VanderPluym, David N. Rosenthal, James K. Kirklin, Ryan S. Cantor, Margaret Tresler, David Michael McMullan, Victor O. Morell, Mark Turrentine, Rebecca Ameduri, Khanh Nguyen, Kirk Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Long-term Outcomes After Transplantation Following Support with a Pulsatile Pediatric Ventricular Assist Device
Heart transplantation remains the most effective long-term palliation for children with end-stage heart failure. Unfortunately, this group of patients continues to have the highest waitlist mortality.1,2 With the introduction of durable ventricular assist devices (VAD) for children, there has been a reduction in this waitlist mortality.3,4 In 2012, the successful Berlin Heart EXCOR Investigational Device Exemption (IDE) trial resulted in the first Food and Drug Administration (FDA) approved pediatric ventricular assist device as a bridge to transplantation (BTT). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 26, 2018 Category: Transplant Surgery Authors: Aamir Jeewa, Michiaki Imamura, Charles Canter, Robert A. Niebler, Christina VanderPluym, David N. Rosenthal, James K. Kirklin, Ryan S. Cantor, Margaret Tresler, David Michael McMullan, Victor O. Morell, Mark Turrentine, Rebecca Ameduri, Khanh Nguyen, Kirk Source Type: research

Pre-Transplant Amiodarone Use and Outcomes in Children After Heart Transplantation
Pre-transplant amiodarone (PTA) use has been associated with worse post-transplant outcomes in adult heart transplantation.1 There are no similar studies in pediatric heart transplantation. The aim of this study was to investigate the impact of PTA on post-transplant outcomes in pediatric heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 24, 2018 Category: Transplant Surgery Authors: Ryan J Butts, Anne I. Dipchand, David Sutcliffe, Maria Bano, Robert Morrow, Richard Kirk Source Type: research

Time-dependent prognostic effects of recipient and donor age in adult heart transplantation
Recipient and donor age are well-known prognostic factors in adult heart transplantation. However, the association between donor and recipient age and their interaction and short- and long-term mortality is unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 17, 2018 Category: Transplant Surgery Authors: Henrik Bergenfeldt, Lars H. Lund, Josef Stehlik, Bodil Andersson, Peter H öglund, Johan Nilsson Tags: Original Clinical Science Source Type: research

Lung transplantation in a patient with Niemann –Pick disease
A 62-year-old, non-smoking, Caucasian male was evaluated for lung transplantation based on severe, upper lobe ‒predominant emphysema with superimposed fibrosis in the lower lung zones (Figure 1). The patient had no significant exposure history, and previous work-up for α1-anti-trypsin deficiency, autoimmune disease, and hypersensitivity pneumonitis was unremarkable. The diagnosis of Niemann‒Pick diseas e Type B was eventually established based on a compatible family history, with an almost identical disease presentation in a sibling. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 15, 2018 Category: Transplant Surgery Authors: Hannah Mannem, Sarah Kilbourne, Max Weder Tags: CASE ANECDOTES, COMMENTS AND OPINIONS Source Type: research

Usefulness of a temporary endovascular left ventricular assist system as a bridge to facilitate treatment of mediastinitis associated with a permanent device
Infections of the driveline exit site are very common and are one of the most common reasons for readmissions of patients with left ventricular assist devices (LVAD). The risk for LVAD infection increases with the duration of LVAD support and after 48 months it is among the top three reasons for death [1-3]. The rate of mortality from LVAD-related mediastinitis is as high as 70% [4,5]. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 15, 2018 Category: Transplant Surgery Authors: M. Mueller, E. Potapov, T. Krabatsch Tags: Case Anecdotes, Comments and Opinions Source Type: research

Lung transplantation in a patient with Niemann-Pick disease
A 62-year old non-smoker, Caucasian male was evaluated for lung transplantation based on severe upper-lobe predominant emphysema with superimposed fibrosis in the lower lung zones (Figure 1). The patient had no significant exposure history, and prior work-up for alpha-1-antitrypsin deficiency, autoimmune disease, and hypersensitivity pneumonitis was unremarkable. The diagnosis of Niemann Pick disease, type B was eventually established based on a compatible family history with an almost identical disease presentation in a sibling. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 15, 2018 Category: Transplant Surgery Authors: Hannah Mannem, Sarah Kilbourne, Max Weder Tags: Case Anecdotes, Comments and Opinions Source Type: research

Validation of a post-transplant chronic lung allograft dysfunction classification system
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction (CLAD). Our study aimed to evaluate prevalence and prognostic importance of obstructive and restrictive CLAD phenotypes with or without identifiable underlying cause to validate the recently proposed classification system for CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 4, 2018 Category: Transplant Surgery Authors: Anke Van Herck, Stijn E. Verleden, Annelore Sacreas, Tobias Heigl, Bart M. Vanaudenaerde, Lieven J. Dupont, Jonas Yserbyt, Eric K. Verbeken, Arne P. Neyrinck, Dirk Van Raemdonck, Geert M. Verleden, Robin Vos Tags: Original Clinical Science Source Type: research

Rapid deployment of an aortic valve prosthesis during ventricular assist device implantation
Aortic valve incompetence in left ventricular assist device (LVAD) patients is a significant management problem, leading to increased workload on the LVAD and inadequate systemic perfusion. During continuous LVAD therapy even mild aortic incompetence is problematic, associated with reduced aortic leaflet opening, progressive fusion of the leaflets and worsening valvular incompetence. Therefore, repair or replacement of the valve is required at the time of LVAD implant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 3, 2018 Category: Transplant Surgery Authors: Shivanand Gangahanamaiah, Silvana F. Marasco Tags: Case Anecdotes, Comments and Opinions Source Type: research

Fontan-associated protein-losing enteropathy and post ‒heart transplant outcomes: A multicenter study
The influence of Fontan-associated protein-losing enteropathy's (PLE) severity, duration, and treatment on heart transplant (HTx) outcomes is unknown. We hypothesized that long-standing PLE and PLE requiring more intensive therapy are associated with increased post-HTx mortality. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 1, 2018 Category: Transplant Surgery Authors: Kurt R. Schumacher, SunkyungYu, Ryan Butts, Chesney Castleberry, Sharon Chen, Erik Edens, Justin Godown, Jonathan Johnson, Mariska Kemna, Kimberly Lin, Ray Lowery, Kathleen Simpson, Shawn West, Ivan Wilmot, Jeffrey G. Gossett Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Editorial Board
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 1, 2018 Category: Transplant Surgery Source Type: research

Information for Readers
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 1, 2018 Category: Transplant Surgery Source Type: research

Table of Contents
(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - October 1, 2018 Category: Transplant Surgery Source Type: research

Assessment of lung edema during ex-vivo lung perfusion by single transpulmonary thermodilution: a preliminary study in humans
Normothermic ex-vivo lung perfusion (EVLP) is a new emerging technique to select lungs from extended-criteria donors. These lungs present edema due to brain-death, harvesting, preservation, or ischemia-reperfusion. However, the identification of appropriate organs is crucial. Combined bench techniques during EVLP rehabilitation are proposed to better assess lung function and predict an adequate graft [1 –3]. However, accurate assessment of the lungs remains challenging because the common tools are insufficiently correlated to the occurrence and severity of primary graft dysfunction (PGD) in recipients. (Source: The J...
Source: The Journal of Heart and Lung Transplantation - October 1, 2018 Category: Transplant Surgery Authors: G. Trebbia, E. Sage, M. Le Guen, A. Roux, A Soummer, P. Puyo, F Parquin, M. Stern, T. Pham, S.G Sakka, C. Cerf, The Foch Lung Transplant group Tags: Original Clinical Science Source Type: research