The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Percutaneous Biventricular Assist Devices Require Fewer Transfusions and Returns to the Operating Room Compared to Classic Surgical Alternative
Purpose: Surgical Biventricular Assist Devices (sBiVADs) are used in end-stage heart failure despite high morbidity and mortality. Less invasive percutaneous BIVAD (pBiVAD) has been utilized but is understudied. In the largest series of pBiVAD patients to date, we compare this cohort to sBiVAD patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Bojko, S. Kobsa, J. Praeger, A. Dhillon, A. Vaidya, A. Wolfson, J. Nattiv, A. Hackmann, R. Lee Source Type: research

Inhibition of ALOX12-12-HETE Alleviates Lung Ischemia Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Traps Formation
Purpose: Lung ischemia reperfusion injury (IRI) is a major cause of primary graft dysfunction after lung transplantation lacking effective treatment. Ferroptosis is a new type of cell death which is driven by iron-dependent lipid peroxidation. However, whether it is involved in lung IRI remains poorly understood. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , P. Gao, F. Zhuang, Z. Wang, Z. Zhou, G. Wu, T. Wang, C. Chen, J. Wu Source Type: research

Defining the Transcripts Associated with a History of Severe Primary Graft Dysfunction in Lung Transplant Transbronchial Biopsies
Purpose: Primary graft dysfunction (PGD) is a severe form of acute lung injury occurring within the first 72 hours post-lung transplant. PGD can result in death and chronic lung dysfunction, but molecular post-PGD tissue changes have not been characterized in lung transplant transbronchial biopsies (TBB). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: M. Mackova, P. Gauthier, A. Hirji, J. Weinkauf, S. Juvet, S. Keshavjee, J. Havlin, A. Zajacova, G. Snell, G. Westall, P. Halloran, Source Type: research

Mitochondrial Xenotransplantation During Ex Vivo Lung Perfusion: Leveraging Rodents as a Fresh Organelle Source to Tackle Ischemia Reperfusion Injury
In this study, we explored the delivery of isolated mitochondria to the organ before Tx. To provide a fresh and viable source of mitochondria, as well as to streamline the workflow without the need for recipient biopsies, we investigated the impact of mitochondrial xenotransplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: N.B. Bechet, A. Celik, Q. Wang, T. Huzevka, M. Mittendorfer, A. Niroomand, E. Boden, G. Hirdman, G. Kjellberg, L. Pierre, F. Olm, J.D. McCully, Source Type: research

Triangular Associations Between the Lower Airway Microbiome, Host Immune Tone, and Primary Graft Dysfunction in Lung Transplantation
Purpose: Lower airway enrichment with oral commensals has been previously demonstrated in grade 3 (severe) primary graft dysfunction (PGD) occurring after lung transplantation (LT). We hypothesized that this dysbiotic signature is present across all PGD grades, including more milder forms, and is associated with a distinct host inflammatory endotype. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , N.C. Nelson, K.K. Wong, I.J. Mahoney, B.G. Wu, T. Malik, D. Rudym, M.B. Lesko, S. Qayum, S.H. Chang, J.C. Chan, T.C. Geraci, T.C. Lewis, F.A. Tiripicchio, Y. Li, P. Pamar, J. Schnier, R. Singh, D.E. Collazo, M. Chang, Y. Kyeremateng, C. McCormick, S. Pa Source Type: research

Machine Learning Using Multi-Site Cytokine Levels is Predictive of Primary Graft Dysfunction Following Lung Transplantation
Purpose: Primary graft dysfunction (PGD) is a syndrome of acute lung injury that occurs in approximately 30% of lung transplant recipients and predisposes to worse long-term outcomes. There is an urgent need to develop point-of-care methods to predict PGD post-transplant. To date, no human studies have investigated cytokine levels in donor lung perfusate, and no multivariable studies have used patient-matched biospecimens from multiple sites. We aimed to identify cytokines at multiple sites whose levels could predict PGD development. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Nord, L. Langerude, H. Moussa, T. Machuca, M. Rackauskas, A. Sharma, C. Lin, A. Emtiazjoo, C. Atkinson Source Type: research

Radiographic Assessment of Lung Edema (RALE) Score on Day 3 After Lung Transplantation is Associated with Poor Clinical Outcomes
Purpose: Primary graft dysfunction (PGD), as defined by hypoxemia and presence of allograft edema, is associated with increased mortality in lung transplant recipients. We tested whether radiographic quantification of pulmonary edema using RALE scoring is associated with PGD severity, hospital length of stay, and death. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Koyama, M. Oyster, L. Kalman, J. Diamond, J. Christie, L. Ware Source Type: research

An In Vitro Study of Virus-Like Particle Mediated CRISPR Gene Editing to Support Gene Modulation in the Human Ex Vivo Lung
Purpose: Dampening ischemia-reperfusion injury (IRI) remains a major challenge in lung transplantation. To intervene with IRI, we hypothesize that CRISPR technology could be leveraged by silencing IRI-related genes in donor lungs. The short time window between lung procurement and implantation requires swift and efficient delivery of the CRISPR machinery. Virus-like particles (VLPs) are promising, as they deliver functional Cas9/sgRNA ribonucleoprotein complexes with high efficiency and increased safety. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Van Slambrouck, M. Bulcaen, R. Quarck, R. Gijsbers, L.J. Ceulemans, M.S. Carlon Source Type: research

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Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Source Type: research

IL-6 Blockade Promotes Tolerance of Heart but Not Lung Allografts in Non-Human Primate Simultaneous Organ and Bone Marrow Transplantation Protocols
Purpose: We previously achieved tolerance of heart allografts in non-human primates (NHPs) using IL-6 signaling blockade in a mixed-chimerism protocol where donor bone marrow transplantation (BMT) occurs simultaneously with solid organ transplantation. Here, we report the differential effect of adding aIL-6R mAb therapy to a simultaneous mixed-chimerism protocol for heart and lung transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J.T. Nawalaniec, J. O, A. Dehnadi, N. Hays, J. Muoio, C. Winter, I. Hanekamp, J. Madsen, J.S. Allan Source Type: research

Porcine IgG Remains within Human Lung After Xenogeneic Cross-Circulation and Human Blood Re-Exposure
Purpose: Our group has previously described human-xenogeneic cross-circulation (XC) as a method to rehabilitate marginal human donor lungs. To simulate subsequent transplantation, we developed a model where the lung is re-exposed to human whole blood after XC. As prior work has demonstrated porcine immune infiltration during XC, we hypothesized that porcine leukocytes and immunoglobulin would remain within the tissue after human blood re-exposure and be recognized by the human immune system. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T.R. Harris, M. Cortelli, S.A. Fran çois, W.D. Tucker, S. DeVries, C.A. Johnson, W. Wu, N.L. Cardwell, M. Petrovic, T.T. Adesanya, A.K. Fortier, K. Raietparvar, E. Simonds, Y. Shishido, C. Pasrija, R. Ukita, C. Demarest, C. Shaver, M. Bacchetta Source Type: research

CD 34+ Cell Therapy is Associated with Improved Myocardial Perfusion in Heart Failure with Preserved Ejection Fraction
Purpose: In HFpEF patients transendocardial CD34+ cell therapy was shown to improve systolic and diastolic properties of the target myocardium. However, the underlying mechanisms remain poorly defined. We sought to evaluate the potential correlation between CD34+ cell therapy and myocardial perfusion in HFpEF patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Zba čnik, S. Frljak, G. Zemljic, A. Cerar, N. Žorž, R. Okrajsek, M. Sebestjen, B. Vrtovec Source Type: research

Ukrainian National Transplant Program During Active Military Invasion
Purpose: Since the beginning of full-scale armed aggression, organ transplantations in Ukraine have been halted due to the need to reconfigure the healthcare system, ongoing missile attacks, and drone strikes with explosives. The influx of refugees from Ukraine and internally displaced persons added to the complexity of the situation. The closure of airspace resulted in additional challenges in adhering to transplantation rules. However, the national waiting list continued to grow. This led to an understanding of the urgent need for a swift response in the field of transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Karamian, V. Strilka, V. Liashko, Y. Stukov Source Type: research

Rethinking Heart Retransplantation - Institutional Success Over Last Decade
Purpose: Heart retransplantation is traditionally considered higher-risk due to recipient factors including prior sternotomy, higher sensitization, greater acuity, and increased comorbidities. We sought to describe our experience with heart retransplantation compared to primary heart transplantation over the preceding decade. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Bakshi, Q. Chen, D. Megna, D. Emerson, T. Gunn, M. Kittleson, J. Patel, J. Chikwe, J. Kobashigawa, M.E. Bowdish, F. Esmailian Source Type: research

Long Term Follow-Up of the Randomized, Prospective Scandinavian Heart Transplant Everolimus De Novo Study with Early Calcineurin Inhibitors Avoidance (SCHEDULE) Trial
Purpose: Early substitution of calcineurin inhibitor (CNI) with mammalian target of rapamycin inhibitors has been shown to improve kidney function and reduce intimal hyperplasia in heart transplant (Htx) recipients but data on long term outcome of such a regime are still sparse. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Andreassen, H. Eiskjaer, F. Gustafsson, G. Radegran, E. Gude, T. Halden, L. Gullestad, K. Broch, K. Karason, S. Bartfay, N. Bergh Source Type: research