The Journal of Heart and Lung Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Outcomes in Donation After Circulatory Death Pediatric Lung Transplants: An Analysis of the ISHLT Registry
Purpose: Donation after circulatory death (DCD) lung transplantation has increased, but there is limited data in children. We sought to characterize the international experience of pediatric DCD lung transplant (LTx) in comparison to donation after brain death (DBD). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: H. Ahmed, S. Hogue, , M. Hossain, Y. Zhang, A. Ashfaq, D. Morales, D. Hayes Source Type: research

Remodeling of the Endothelial Extracellular Matrix (ECM) Drives Smooth Muscle Cell Hyperplasia in Pulmonary Hypertension Due to Left Heart Disease
Purpose: Pulmonary hypertension (PH) is a major complication of left heart disease (LHD) that ultimately leads to right ventricular failure with a poor prognosis. It is initiated by passive congestion of blood from the left heart into the pulmonary circulation and is aggravated by pulmonary arterial (PA) remodeling. PA smooth muscle cell (SMC) hyperplasia elevates PA blood pressure (PAP) and pulmonary vascular resistance (PVR) by reducing the patent PA lumen. Here, we addressed the role of the endothelial ECM (the basement membrane, BM) in regulating SMC hyperplasia in PH-LHD and identified potential therapeutic targets. (...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Gransar, S. Liu, V. Falk, M.M. Kucherenko, W.M. K übler, C. Knosalla Source Type: research

Pulmonary Vasculopathy in Heart Failure: Is the New Threshold > 2 Wood Units Relevant in Advanced HF Population ?
Purpose: There is an ongoing debate on the optimal metrics and the threshold for prognostically relevant pulmonary vascular disease (PVD) due to heart failure (HF). In 2022 PH guidelines, based general HF population data, the threshold for relevant PVD was lowered to pulmonary vascular resistance (PVR) (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , H. Al-Hiti, A. Reichenbach, D. Jenca, J. Benes, K. Kroupova, M. Kotrc Source Type: research

Micro-CT Based Approach to Quantitatively Evaluate Vascular Changes in Pulmonary Arterial Hypertension
In this study, we present an innovative approach to quantitatively characterize these vascular changes using micro computed tomography ( μCT) in severe PAH patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Willems, R. Anthonissen, B. De Jonghe, J. Michiels, R. Celen, J. Verhaegen, A. Vermaut, V. Geudens, C. Hooft, P. Kerckhof, H. Beeckmans, J. Kaes, Y. Mohamady, L. Hardy, J. Van Slambrouck, B. Tielemans, B. Weynand, L. Ceulemans, R. Vos, G. Gayan-Ramir Source Type: research

Diagnostic Accuracy of Automatic Tricuspid Regurgitation Jet Velocity for Detecting Pulmonary Hypertension
This study evaluated the performance and utility of an existing tool (US2.AI) in a consecutive cohort of patients with suspected PH. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Alabed, M. Sharkey, A. Maiter, K. Dwivedi, T. Yardibi, M. Selej, A. Hameed, A. Charalampopoulos, D. Kiely, A.J. Swift Source Type: research

Prediction of Long-Term Survival by Three Risk Assessment Models in Patients with Pulmonary Arterial Hypertension: A SPAHR Analysis
Purpose: Multicomponent clinical improvement (MCI) is a novel endpoint for predicting survival in patients with pulmonary arterial hypertension (PAH) included in the sotatercept clinical program. We investigated the prognostic value of MCI, ESC/ERS 4-strata risk (4SR) assessment, and the French risk stratification score (FRS) for predicting survival in a real-world cohort of PAH patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Thakur, T. Weiss, E. Bj örklund, J. Papageorgiou, G. Radegran, S. Soderberg, H. Wahlander, D. Lautsch, B. Kjellström Source Type: research

Long-Term Outcomes of a Novel Fully Magnetically Levitated Ventricular Assist Device for the Treatment of Advanced Heart Failure in China
This study reports the long-term outcomes of a cohort supported by the CH-VAD for the first time. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , X. Zhou, H. Chen, J. Du, L. Zou, P. Qing, F. Duan, S. Yuan, J. Shi, B. Ji, S. Hu Source Type: research

HeartMate 3 LVAD Outflow Graft Velocity Profile as Simplified Marker for Left Ventricular Unloading in Echocardiographic Speed Ramp Tests
Purpose: Pump speed optimization in left ventricular assist device (LVAD) recipients is essential to reach optimal hemodynamic support and left ventricular (LV) unloading, while avoiding overpumping. The primary objective of this study was to assess the potential of LVAD outflow graft (OG) velocity profiles as marker for LV unloading, aiming to establish a simplified echocardiographic speed ramp test protocol. The secondary objective was to correlate OG velocities with real-time HeartMate 3 (HM3) Snoopy pump data, serving as non-invasive diagnostic tool. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Abart, G. Widhalm, J. Riebandt, A. Kahrovic, C. Marko, G. Laufer, D. Wiedemann, D. Zimpfer, T. Schloeglhofer Source Type: research

Development of a Destination Therapy Right Heart Replacement Pump for Failing Fontan Patients
Purpose: Heart transplantation for failing Fontan patients remains a challenge due to comorbidities, prior surgeries with allosensitization, and competition for donor organs. We are developing a mechanical circulatory support (MCS) system specifically for the anatomic and hemodynamic requirements of a sub-pulmonary pump. Our goal is provide destination support as an alternative to transplantation, with consideration for quality of life and the young age range of this population. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Newswanger, C. Jhun, C. Scheib, K. Bohnenberger, J. Cysyk, J. Clark, J. Myers, I. Jenelle, G. Rosenberg Source Type: research

The Effect of Rotational Speed Modulated Right Ventricular Assist Device on Hemodynamics in the Application of Continuous-Flow Biventricular Assist Device
Purpose: In the application of a biventricular assist device(BVAD), the flow balance between a left ventricular assist device (LVAD) and a right ventricular assist device(RVAD) is still controversial. The purpose of this study was to evaluate the effect of RVAD rotational speed modulation designed to control BVAD flow balance. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Nishinaka, K. Imoto, T. Murakami, S. Imaoka, T. Mizuno, T. Tsukiya, M. Ono Source Type: research

Enhancing Usability and Safety: Comparative Evaluation of Corwave and Heartmate 3 LVAD Peripherals in Simulated Scenarios
This study aimed to compare the usability of CorWave LVAD (CW) peripherals prototypes with HeartMate 3 LVAD (HM3) wearables in simulated everyday and emergency scenarios. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Abart, K. Ebenberger, A. Berger, J. Riebandt, D. Wiedemann, D. Zimpfer, M. Wagner, T. Schloeglhofer Source Type: research

Adverse Events Occur Frequently in the Teammate Trial Cohort: Comparison by Treatment Group During 30 Months of Follow Up
Purpose: The TEAMMATE Trial is the first randomized clinical trial of immunosuppression in pediatric heart transplant (HT) recipients. We will describe adverse events (AEs) that occurred during the trial (currently embargoed). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T.P. Singh, L.A. Sleeper, J.C. Alejos, R.K. Ameduri, S.R. Auerbach, N. Bansal, L. Barkoff, A. Barnes, M.J. Bock, A. Butto, R. Butts, W.F. Carlo, C. Castleberry, M. Chrisant, S. Deshpande, W.J. Dreyer, B. Feingold, J. Friedland-Little, S.A. Hollander, A. Source Type: research

Factors Associated with Prolonged Length of Stay After Pediatric Heart Transplantation
Purpose: Prolonged hospital length of stay (LOS) after pediatric heart transplant (HT) is a major burden on patients and families and a strain on hospital resources. Little is known about the factors associated with prolonged LOS or whether some are modifiable. We sought to evaluate trends in hospital LOS for pediatric HT recipients and identify factors associated with prolonged LOS in the current era. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. Profita, C. Chen, S. Hollander, M. Ma, E. Martin, L. Barkoff, D. Kwiatkowski, A. Shin, C. Almond Source Type: research

Impact of Primary Graft Failure: Analysis of the PHTS Database
Purpose: Primary graft failure (PGF) is a leading cause of early morbidity and mortality after heart transplant (HTx). It manifests as allograft dysfunction in the absence of other causes. While the impact of PGF on early mortality in pediatrics has been described, it is unclear if PGF also influences long-term survival and post-HTx complications. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T. Pidborochynski, J. Kirklin, R. Cantor, H. Zhao, A. Sheybani, J. Lamour, L.G. Hahn, L. Collins, J. Laks, D.H. Freed Source Type: research

How Well Does the Molecular Microscope Diagnostic System (MMDx) Correlate with Traditional Pathologic Biopsy Interpretation in a Pediatric Heart Transplant Population?
Purpose: Histologic evaluation of endomyocardial biopsies (EMB) is the gold-standard for diagnosis of rejection post heart transplant (HT), but the methodology is subject to interobserver variability and sampling error. The molecular microscope diagnostic system (MMDx) analyzes RNA transcripts from EMB tissue to differentiate quiescent allograft tissue from that with rejection/injury. While MMDx results have been described in adult HT cohorts, less is known about its utility in pediatric patients which differ regarding indications for HT, degree of anti-HLA sensitization, and post HT immunosuppression. (Source: The Journal...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , T.P. Singh, G. Nava, M. Clark, R. Kobayashi, P. Esteso, C. Carreon, A. Al-Ibraheemi, L.A. Sleeper, K.P. Daly Source Type: research